EP1622503A1 - Procede et dispositif de determination de composants sanguins par spectroscopie d'impulsions absolue ratiometrique - Google Patents
Procede et dispositif de determination de composants sanguins par spectroscopie d'impulsions absolue ratiometriqueInfo
- Publication number
- EP1622503A1 EP1622503A1 EP04720580A EP04720580A EP1622503A1 EP 1622503 A1 EP1622503 A1 EP 1622503A1 EP 04720580 A EP04720580 A EP 04720580A EP 04720580 A EP04720580 A EP 04720580A EP 1622503 A1 EP1622503 A1 EP 1622503A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- light
- concentration
- evaluation unit
- wavelength
- blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 title claims abstract description 32
- 239000012503 blood component Substances 0.000 title claims abstract description 14
- 238000004611 spectroscopical analysis Methods 0.000 title description 20
- 108010054147 Hemoglobins Proteins 0.000 claims abstract description 30
- 102000001554 Hemoglobins Human genes 0.000 claims abstract description 30
- 238000005259 measurement Methods 0.000 claims abstract description 18
- 238000011156 evaluation Methods 0.000 claims abstract description 17
- 238000007792 addition Methods 0.000 claims abstract description 3
- 238000002798 spectrophotometry method Methods 0.000 claims abstract description 3
- 239000000306 component Substances 0.000 claims description 8
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 claims description 7
- 239000000975 dye Substances 0.000 claims description 4
- 102000036675 Myoglobin Human genes 0.000 claims description 2
- 108010062374 Myoglobin Proteins 0.000 claims description 2
- 230000002123 temporal effect Effects 0.000 claims description 2
- 239000000126 substance Substances 0.000 abstract description 29
- 210000004369 blood Anatomy 0.000 abstract description 17
- 239000008280 blood Substances 0.000 abstract description 17
- 210000001519 tissue Anatomy 0.000 description 8
- 230000009102 absorption Effects 0.000 description 7
- 238000010521 absorption reaction Methods 0.000 description 7
- 230000003595 spectral effect Effects 0.000 description 7
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 6
- 230000008033 biological extinction Effects 0.000 description 6
- 229910052760 oxygen Inorganic materials 0.000 description 6
- 239000001301 oxygen Substances 0.000 description 6
- 239000006096 absorbing agent Substances 0.000 description 5
- 230000003313 weakening effect Effects 0.000 description 5
- 238000000862 absorption spectrum Methods 0.000 description 4
- 230000000541 pulsatile effect Effects 0.000 description 3
- 239000004065 semiconductor Substances 0.000 description 3
- COXVTLYNGOIATD-HVMBLDELSA-N CC1=C(C=CC(=C1)C1=CC(C)=C(C=C1)\N=N\C1=C(O)C2=C(N)C(=CC(=C2C=C1)S(O)(=O)=O)S(O)(=O)=O)\N=N\C1=CC=C2C(=CC(=C(N)C2=C1O)S(O)(=O)=O)S(O)(=O)=O Chemical compound CC1=C(C=CC(=C1)C1=CC(C)=C(C=C1)\N=N\C1=C(O)C2=C(N)C(=CC(=C2C=C1)S(O)(=O)=O)S(O)(=O)=O)\N=N\C1=CC=C2C(=CC(=C(N)C2=C1O)S(O)(=O)=O)S(O)(=O)=O COXVTLYNGOIATD-HVMBLDELSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 229960003699 evans blue Drugs 0.000 description 2
- 230000000642 iatrogenic effect Effects 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000002106 pulse oximetry Methods 0.000 description 2
- 238000007430 reference method Methods 0.000 description 2
- 239000013558 reference substance Substances 0.000 description 2
- 240000002791 Brassica napus Species 0.000 description 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
- 108010061951 Methemoglobin Proteins 0.000 description 1
- 108010016811 Sulfhemoglobin Proteins 0.000 description 1
- 241000906446 Theraps Species 0.000 description 1
- 238000008050 Total Bilirubin Reagent Methods 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 235000013405 beer Nutrition 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 210000003811 finger Anatomy 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000005375 photometry Methods 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 210000003371 toe Anatomy 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
Definitions
- the invention further relates to a device for the measurement of blood components by measurement, which has at least one light source, at least one photo receiver and at least one evaluation unit which is connected to the photo receiver.
- a device for the measurement of blood components by measurement which has at least one light source, at least one photo receiver and at least one evaluation unit which is connected to the photo receiver.
- Such methods and devices are used in order to be able to carry out blood tests in the field of medical technology without having to take blood from a patient.
- such devices are arranged, for example, on a patient's fingers, toes, ears or on the nose.
- Hemoglobin derivatives can be divided into
- Functional components are the 0 ⁇ - hemoglobin and the deoxygenated hemoglobin fraction, while the dysfunctional 11 hemoglobin fractions mainly include carboxymonoxide hemoglobin, methemoglobin and sulfhemoglobin.
- Native components are those that are present within the blood space in a physiologically or pathologically modified manner.
- Iatrogenic substances are substances applied by the doctor, eg dyes for marking certain clinical parameters.
- a diagnostic method that uses spectrophotometry to refer to the pulsating blood compartment in biological tissues is called PULSE SPECTROSCOPY.
- a well-known example of relative pulse spectroscopy is the determination of arterial oxygen saturation by means of the pulse oximetry method. The percentage of hemoglobin that accumulates with oxygen is determined. In this case, hemoglobin is the reference substance, but its absolute concentration cannot be determined in relative pulse spectroscopy.
- Absolute pulse spectroscopy determines substance concentrations that are present within the pulsating arterial or venous blood space. These can be both corpuscularly bound (i.e. Be part of blood cells or be dissolved within the blood plasma.
- the determinable substances are not necessarily substances associated with hemoglobin. They can exist independently of this molecule.
- This object is achieved in that light signals of a first wavelength are generated at two successive times T-_ and T 2 , that light signals of a second wavelength are generated at two successive times T 3 and T 4 , that at two successive times T s and T 6 light signals of a third wavelength are generated and this for n pairs of times at n wavelengths applies.
- the times T x ... T n + 1 are in a well-defined temporal relationship to each other. Time differences between the times can be small and can be neglected in the evaluation in individual cases.
- the evaluation unit takes into account the received signals of the photoreceiver for all n wavelengths according to a predetermined calculation scheme to determine a concentration of the blood component.
- Another object of the present invention is to provide a device of the type mentioned in the introduction in such a way that improved measurement accuracy is achieved.
- This object is achieved according to the invention in that at least three light sources are used which generate light of different wavelengths relative to one another and in that the evaluation unit has a computing module for performing logarithmizations as well as for divisions, multiplications, additions and subtractions.
- a signal processing step for eliminating unknown parameters consists in that the evaluation unit takes into account a quotient of parameters resulting from measurement signals ("ratiometric method")
- a transformation of a division into a subtraction that occurs during logarithization is exploited by taking into account a quotient from the logarithmized measured values.
- a simple device structure is supported in that the light is generated by light-emitting semiconductor diodes. These classic emission diodes (or laser diodes) can be used as photometric emission elements without further spectral filtering.
- 3 shows a schematic representation of the formation of the measured value variables Omega 1,2 and Omega 1,3 from two sampling times t x and t 2 three plethysmograms of different wavelengths
- Fig. 6 absorption spectrum whole blood at sa02 approx. 98% and absorption spectrum water. Please note the spectral absorption curve H20 between 1000 [nm] and 1600 [nm],
- Fig. 8 absorption spectrum of the clinical marker substance Evans-Blue (aqueous solution 70 [ ⁇ mol / 1])
- the device for determining a concentration of blood components by measurement consists, for example, of consists of three light sources (1, 2, 3) and a number of photo receivers (4).
- the light sources (1, 2, 3) are designed as light-emitting diodes, selected by a multiplexer and connected to a control unit (5).
- the photo receivers are designed as light-emitting diodes, selected by a multiplexer and connected to a control unit (5).
- the evaluation unit (6) has a computing module (7) which contains the measurement signals of the photo receiver
- the determined concentrations of the blood components can be shown on a display (8) and / or passed on or saved via an output device (9).
- the control unit (5) is connected to the evaluation unit (6) for function coordination.
- Figure 2 shows a typical layer model to illustrate the basics of pulse spectroscopy. Shown is the weakening of the light intensity due to the absorption on the one hand in the non-pulsating tissue part (layer 1) and the weakening within the pulsating tissue part (layer 2), which causes the pulsating fluctuation in the emerging light intensity.
- the measured light intensities are arithmetically linked at different times and with respect to different light wavelengths in such a way that certain unknown measurement parameters drop out.
- the arithmetic logic of the measured values takes advantage of the fact that a division is transformed into a subtraction during logarithmization. If the quotient of two measured variables is thus formed at different points in time, the respective measured variable influencing but constant in time and unnecessary parameters drop out.
- e are the molar extinctions on which the respective substances are based, c the respective concentrations.
- D ⁇ is the total thickness of the constant tissue.
- d A (t) is the pulse-cyclic, time-dependent thickness of the pulsating blood vessels.
- hemoglobin derivatives are given, for example, with O 2 Hb and HbR. Then we get:
- a blood component X can be determined non-invasively and continuously if the hemoglobin concentration c Hb is known (measured, for example, by reference method) (I).
- the hemoglobin concentration c ⁇ itself can be determined if another pulsating absorber is known regarding its concentration (II). In principle, both determination methods can be implemented independently of one another.
- Epsilon X and c x are the molar extinction and the concentration of a blood component that must not be hemoglobin-associated.
- Relationships (6) and (6a) can be used to determine the substance concentration X, which may not be associated with hemoglobin.
- This can be, for example, bilirubin or other native blood substances, and furthermore this substance X can be an iatrogenically applied substance, such as e.g. represent a dye marker substance.
- iatrogenically administered substances can also be applied in order to dope native or pharmacologically active substances.
- the measurement variable mentioned ⁇ 12 does not necessarily have to be the measurement variable on which the pulse oximetric determination of arterial oxygen saturation is based.
- This determination equation of sa ⁇ 2 depends on the as yet unknown substance concentration CJJJ-, if A x ( ⁇ ) and S ( ⁇ 2 / Sl) are known. This concentration tion can now be determined that a further wavelength ⁇ 3 is introduced, and this is also used according to the given arrangement for determining sa ⁇ 2 .
- a x ( ⁇ 3 ) c x ⁇ x ( ⁇ ] _) is the known absorption of a substance X.
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Pathology (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Optics & Photonics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Biochemistry (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
L'invention concerne un procédé et un dispositif de détermination, par mesure non invasive, de concentrations de composants sanguins. De la lumière est produite par au moins une source lumineuse par photométrie spectrale et guidée vers au moins un photorécepteur au travers d'un tissu perforé de façon pulsatile, situé sur le point d'application. Au moins le signal de mesure du photorécepteur est guidé vers une unité d'évaluation. A des paires d'instants consécutifs (T1 et T2, T3 et T4, T5 et T6, , Tn et Tn+1), des signaux lumineux d'une première, deuxième, troisième jusqu'à n+1ème longueurs d'ondes sont produits. L'unité d'évaluation fait intervenir les signaux de réception du photorécepteur pour toutes les longueurs d'ondes, selon un schéma de calcul prédéfini, afin de déterminer une concentration des composants sanguins. Ledit dispositif comporte au moins trois sources lumineuses produisant de la lumière à des longueurs d'ondes différentes. L'unité d'évaluation est pourvue d'un module de calcul destiné à la mise en oeuvre de logarithmes, ainsi que de divisions, multiplications, additions et soustractions. Ledit procédé peut notamment servir à la détermination de la concentration totale en hémoglobine CHb, et à la détermination de substances physiologiques, appliquées de façon iatrogène, du volume sanguin pulsé.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10321338A DE10321338A1 (de) | 2003-05-13 | 2003-05-13 | Verfahren und Vorrichtung zur Bestimmung von Blutkomponenten mittels der Methode der ratiometrischen absoluten Pulsspektroskopie |
| PCT/DE2004/000515 WO2004100780A1 (fr) | 2003-05-13 | 2004-03-15 | Procede et dispositif de determination de composants sanguins par spectroscopie d'impulsions absolue ratiometrique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP1622503A1 true EP1622503A1 (fr) | 2006-02-08 |
Family
ID=33394512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP04720580A Withdrawn EP1622503A1 (fr) | 2003-05-13 | 2004-03-15 | Procede et dispositif de determination de composants sanguins par spectroscopie d'impulsions absolue ratiometrique |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20080214911A1 (fr) |
| EP (1) | EP1622503A1 (fr) |
| JP (1) | JP2007502681A (fr) |
| DE (1) | DE10321338A1 (fr) |
| WO (1) | WO2004100780A1 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT501698B1 (de) * | 2005-03-18 | 2007-04-15 | Felix Dipl Ing Dr Himmelstoss | Vorrichtung zur mehrpulserfassung |
| US7904130B2 (en) | 2005-09-29 | 2011-03-08 | Nellcor Puritan Bennett Llc | Medical sensor and technique for using the same |
| DE112006003694A5 (de) * | 2005-11-15 | 2008-10-23 | Weinmann Geräte für Medizin GmbH + Co. KG | Vorrichtung zur Bestimmung physiologischer Variablen |
| DE102007063934B3 (de) | 2006-04-07 | 2019-07-11 | Löwenstein Medical Technology S.A. | Vorrichtung zur Ermittlung von Biosignalen |
| US8175667B2 (en) | 2006-09-29 | 2012-05-08 | Nellcor Puritan Bennett Llc | Symmetric LED array for pulse oximetry |
| US8068891B2 (en) | 2006-09-29 | 2011-11-29 | Nellcor Puritan Bennett Llc | Symmetric LED array for pulse oximetry |
| US8649838B2 (en) | 2010-09-22 | 2014-02-11 | Covidien Lp | Wavelength switching for pulse oximetry |
| DE102012111105A1 (de) | 2012-11-19 | 2014-05-22 | Uwe Gräßel | Verfahren zur Rückgewinnung von säurehaltigen Beizlösungen |
| US11154224B2 (en) | 2018-01-09 | 2021-10-26 | Medtronic Monitoring, Inc. | System and method for non-invasive monitoring of hematocrit concentration |
| US11051727B2 (en) | 2018-01-09 | 2021-07-06 | Medtronic Monitoring, Inc. | System and method for non-invasive monitoring of advanced glycation end-products (AGE) |
| US11039768B2 (en) | 2018-01-09 | 2021-06-22 | Medtronic Monitoring, Inc. | System and method for non-invasive monitoring of hemoglobin |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4911167A (en) * | 1985-06-07 | 1990-03-27 | Nellcor Incorporated | Method and apparatus for detecting optical pulses |
| US5564417A (en) * | 1991-01-24 | 1996-10-15 | Non-Invasive Technology, Inc. | Pathlength corrected oximeter and the like |
| US5058588A (en) * | 1989-09-19 | 1991-10-22 | Hewlett-Packard Company | Oximeter and medical sensor therefor |
| US5337745A (en) * | 1992-03-10 | 1994-08-16 | Benaron David A | Device and method for in vivo qualitative or quantative measurement of blood chromophore concentration using blood pulse spectrophotometry |
| US5377674A (en) * | 1992-05-08 | 1995-01-03 | Kuestner; J. Todd | Method for non-invasive and in-vitro hemoglobin concentration measurement |
| JP3364819B2 (ja) * | 1994-04-28 | 2003-01-08 | 日本光電工業株式会社 | 血中吸光物質濃度測定装置 |
| DE19512478C2 (de) * | 1994-08-10 | 2001-05-31 | Bernreuter Peter | Verfahren zur Bestimmung der arteriellen Sauerstoffsättigung |
| WO1997049330A1 (fr) * | 1996-06-27 | 1997-12-31 | Falcon Medical, Inc. | Oxymetre resistant aux artefacts dus aux mouvements utilisant trois longueurs d'ondes |
| US6163715A (en) * | 1996-07-17 | 2000-12-19 | Criticare Systems, Inc. | Direct to digital oximeter and method for calculating oxygenation levels |
| WO1998017174A1 (fr) * | 1996-10-23 | 1998-04-30 | Cardiac Crc Nominees Pty. Limited | Determination non invasive de la saturation en oxygene dans le sang des tissus profonds |
| GB2328279B (en) * | 1997-08-12 | 2001-10-10 | Abbott Lab | Optical glucose detector |
| JPH11244267A (ja) * | 1998-03-03 | 1999-09-14 | Fuji Photo Film Co Ltd | 血中成分濃度測定装置 |
| JP2002516689A (ja) * | 1998-06-03 | 2002-06-11 | マシモ・コーポレイション | ステレオパルスオキシメータ |
| JP2000083933A (ja) * | 1998-07-17 | 2000-03-28 | Nippon Koden Corp | 生体組織中吸光物質濃度測定装置 |
| JP2961608B1 (ja) * | 1998-10-02 | 1999-10-12 | 建夫 斎藤 | 酸素飽和度測定装置 |
| US6622095B2 (en) * | 1999-11-30 | 2003-09-16 | Nihon Kohden Corporation | Apparatus for determining concentrations of hemoglobins |
| JP2002315739A (ja) * | 2001-02-15 | 2002-10-29 | Nippon Koden Corp | ヘモグロビン濃度測定装置 |
| JP3811850B2 (ja) * | 2001-11-06 | 2006-08-23 | 日本光電工業株式会社 | 生体内水分量関連値測定装置 |
-
2003
- 2003-05-13 DE DE10321338A patent/DE10321338A1/de not_active Withdrawn
-
2004
- 2004-03-15 WO PCT/DE2004/000515 patent/WO2004100780A1/fr active Application Filing
- 2004-03-15 EP EP04720580A patent/EP1622503A1/fr not_active Withdrawn
- 2004-03-15 JP JP2006529569A patent/JP2007502681A/ja active Pending
- 2004-03-15 US US10/556,652 patent/US20080214911A1/en not_active Abandoned
Non-Patent Citations (1)
| Title |
|---|
| See references of WO2004100780A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007502681A (ja) | 2007-02-15 |
| DE10321338A1 (de) | 2004-12-02 |
| WO2004100780A1 (fr) | 2004-11-25 |
| US20080214911A1 (en) | 2008-09-04 |
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