EP1605895A4 - Orale insulintherapien und protokoll - Google Patents

Orale insulintherapien und protokoll

Info

Publication number
EP1605895A4
EP1605895A4 EP04718148A EP04718148A EP1605895A4 EP 1605895 A4 EP1605895 A4 EP 1605895A4 EP 04718148 A EP04718148 A EP 04718148A EP 04718148 A EP04718148 A EP 04718148A EP 1605895 A4 EP1605895 A4 EP 1605895A4
Authority
EP
European Patent Office
Prior art keywords
protocol
oral insulin
insulin therapies
therapies
oral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04718148A
Other languages
English (en)
French (fr)
Other versions
EP1605895A2 (de
Inventor
Ehud Arbit
Michael Goldberg
Shingai Majuru
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emisphere Technologies Inc
Original Assignee
Emisphere Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emisphere Technologies Inc filed Critical Emisphere Technologies Inc
Publication of EP1605895A2 publication Critical patent/EP1605895A2/de
Publication of EP1605895A4 publication Critical patent/EP1605895A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
EP04718148A 2003-03-06 2004-03-05 Orale insulintherapien und protokoll Withdrawn EP1605895A4 (de)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US448465P 2003-02-21
US45266003P 2003-03-06 2003-03-06
US452660P 2003-03-06
US48846503P 2003-07-17 2003-07-17
US49729603P 2003-08-22 2003-08-22
US497296P 2003-08-22
US51816803P 2003-11-07 2003-11-07
US518168P 2003-11-07
US53509104P 2004-01-07 2004-01-07
US535091P 2004-01-07
US54046204P 2004-01-29 2004-01-29
US540462P 2004-01-29
PCT/US2004/006943 WO2004080401A2 (en) 2003-03-06 2004-03-05 Oral insulin therapies and protocol

Publications (2)

Publication Number Publication Date
EP1605895A2 EP1605895A2 (de) 2005-12-21
EP1605895A4 true EP1605895A4 (de) 2011-08-24

Family

ID=35457030

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04718148A Withdrawn EP1605895A4 (de) 2003-03-06 2004-03-05 Orale insulintherapien und protokoll

Country Status (5)

Country Link
EP (1) EP1605895A4 (de)
JP (1) JP5658619B2 (de)
AU (1) AU2004220544B2 (de)
CA (1) CA2518216C (de)
WO (1) WO2004080401A2 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
DE60318938T2 (de) 2002-03-20 2009-01-22 Mannkind Corp., Valencia Inhalationsgerät
US7658721B2 (en) 2004-01-16 2010-02-09 Biodel Inc. Sublingual drug delivery device
US20080090753A1 (en) 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
NZ551196A (en) 2004-05-14 2010-08-27 Emisphere Tech Inc Compounds and compositions for delivering active agents
JP5122954B2 (ja) 2004-05-19 2013-01-16 エミスフェアー・テクノロジーズ・インク アシクロビル製剤
ES2385934T3 (es) 2004-08-20 2012-08-03 Mannkind Corporation Catálisis de la síntesis de dicetopiperazina.
EP2314298B1 (de) 2004-08-23 2015-05-27 MannKind Corporation Mikropartikel enthaltend Diketopiperazinsalze zur Arzneimitteldarreichung
ES2535311T3 (es) 2004-12-29 2015-05-08 Emisphere Technologies, Inc. Formulaciones farmacéuticas de sales de galio
WO2006076692A1 (en) 2005-01-12 2006-07-20 Emisphere Technologies, Inc. Compositions for buccal delivery of parathyroid hormone
WO2006084164A2 (en) 2005-02-01 2006-08-10 Emisphere Technologies, Inc. Gastric retention and controlled release delivery system
JP2009503093A (ja) * 2005-08-01 2009-01-29 マンカインド コーポレイション インスリン産生細胞の機能を保持する方法
KR20160022404A (ko) 2005-09-14 2016-02-29 맨카인드 코포레이션 활성제에 대한 결정질 미립자 표면의 친화력의 증가를 기반으로 하는 약물 제제화의 방법
MX2008010721A (es) 2006-02-22 2008-09-01 Mannkind Corp Un metodo para mejorar las propiedades farmaceuticas de microparticulas que contienen dicetopiperazina y un agente activo.
US8927015B2 (en) * 2006-04-12 2015-01-06 Emisphere Technologies, Inc. Formulations for delivering insulin
US8771712B2 (en) 2006-05-09 2014-07-08 Emisphere Technologies, Inc. Topical administration of acyclovir
CA2656019C (en) 2006-06-28 2016-09-13 Emisphere Technologies, Inc. Gallium nitrate formulations
EP3281663B8 (de) 2008-06-13 2022-09-21 MannKind Corporation Atemluftbetriebener trockenpulverinhalator zur verabreichung von medikamenten
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
MX2010014240A (es) 2008-06-20 2011-03-25 Mankind Corp Un metodo y aparato interactivo para perfilar en tiempo real esfuerzos de inhalacion.
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
CA2754595C (en) 2009-03-11 2017-06-27 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
US8551528B2 (en) 2009-06-12 2013-10-08 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
US20110039930A1 (en) 2009-08-03 2011-02-17 Emisphere Technologies, Inc. Fast-acting naproxen composition with reduced gastrointestinal effects
EP2496295A1 (de) 2009-11-03 2012-09-12 MannKind Corporation Vorrichtung und verfahren zur simulation von einatmungsanstrengungen
BR112012033060A2 (pt) 2010-06-21 2018-02-27 Mannkind Corp métodos de sistema de liberação de fármaco em pó seco
KR101940832B1 (ko) 2011-04-01 2019-01-21 맨카인드 코포레이션 의약 카트리지용 블리스터 패키지
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
EP2776053A1 (de) 2011-10-24 2014-09-17 MannKind Corporation Verfahren und zusammensetzungen zur schmerzbehandlung
SG11201500218VA (en) 2012-07-12 2015-03-30 Mannkind Corp Dry powder drug delivery systems and methods
EP2911690A1 (de) 2012-10-26 2015-09-02 MannKind Corporation Inhalierbare influenza-impfstoffzusammensetzungen und verfahren
EP3875959A1 (de) 2012-12-26 2021-09-08 Quest Diagnostics Investments Incorporated C-peptid-nachweis mittels massenspektrometrie
EP3587404B1 (de) 2013-03-15 2022-07-13 MannKind Corporation Mikrokristalline diketopiperazinzusammensetzungen, verfahren zur herstellung und deren verwendung
BR122019026637B1 (pt) 2013-07-18 2023-09-26 Mannkind Corporation Formulações farmacêuticas de pó seco e método para a fabricação de uma formulação de pó seco
CA2920488C (en) 2013-08-05 2022-04-26 Mannkind Corporation Insufflation apparatus and methods
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
JP2021528424A (ja) * 2018-06-18 2021-10-21 バイオコン・リミテッドＢｉｏｃｏｎ Ｌｉｍｉｔｅｄ 対象における食後のグルコースレベルをコントロールする方法および使用
EP3902469A4 (de) * 2018-12-28 2022-08-10 Dexcom, Inc. Auswertung und visualisierung von glykämischer dysfunktion

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002002509A1 (en) * 2000-06-29 2002-01-10 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
WO2003057170A2 (en) * 2002-01-07 2003-07-17 Emisphere Technologies, Inc. Oral insulin therapy

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5665389A (en) * 1995-05-24 1997-09-09 University Of Maryland At Baltimore Oral dosage composition for intestinal delivery and method of treating diabetes
WO2000064940A1 (en) * 1999-04-27 2000-11-02 Eli Lilly And Company Insulin crystals for pulmonary administration
US7060675B2 (en) * 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US7137951B2 (en) * 2002-10-23 2006-11-21 Joseph Pilarski Method of food and insulin dose management for a diabetic subject
US7384914B2 (en) * 2003-01-06 2008-06-10 Emisphere Technologies, Inc. Night-time oral insulin therapy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002002509A1 (en) * 2000-06-29 2002-01-10 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
WO2003057170A2 (en) * 2002-01-07 2003-07-17 Emisphere Technologies, Inc. Oral insulin therapy

Also Published As

Publication number Publication date
EP1605895A2 (de) 2005-12-21
WO2004080401A3 (en) 2006-01-12
AU2004220544B2 (en) 2010-06-17
JP5658619B2 (ja) 2015-01-28
WO2004080401A2 (en) 2004-09-23
JP2011162560A (ja) 2011-08-25
AU2004220544A1 (en) 2004-09-23
CA2518216A1 (en) 2004-09-23
CA2518216C (en) 2017-05-09

Similar Documents

Publication Publication Date Title
EP1605895A4 (de) Orale insulintherapien und protokoll
HK1253918A1 (zh) 可吸入腎上腺素
EP1469812A4 (de) Orale insulintherapie
EP1648327A4 (de) Orale vorrichtungen und verfahren für die kontrollierte arzneimittelabgabe
AU2003904278A0 (en) Improved oral oxygenating device
EP1539129A4 (de) Dosierformen und relevante therapien
IL176248A0 (en) N-substituted-n-sulfonylaminocyclopropane compounds and pharmaceutical use thereof
HK1085131A1 (en) Solid drug for oral use
HK1085133A1 (en) Night-time oral insulin therapy
AU2003268419A1 (en) Combined toothbrush and flossing device
EP1619193A4 (de) Spiropiperidinverbindung und deren medizinische verwendung
EP1661594A4 (de) Spritze
AU2003259457A8 (en) Auto-destructible syringe
EP1620066A4 (de) Mundpflegeverfahren und -produkte
AU2003208673A1 (en) Pacifier for administering flavour substances
GB0308382D0 (en) Therapeutic methods and means
AP2006003666A0 (en) Syringe
GB2401043B (en) Drug
GB0222090D0 (en) Dental methods
AU2003277757A1 (en) Dental handpiece
EP1653953A4 (de) Verfahren und vorrichtungen für die arzneimittelabgabe
EP1624073A4 (de) Arzneistoff
AU2003303329A1 (en) Dental handpiece
AU2003906273A0 (en) Oral insert/sleep monitor/communication device
GB0327912D0 (en) Medicament

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20051006

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK

PUAK Availability of information related to the publication of the international search report

Free format text: ORIGINAL CODE: 0009015

R17D Deferred search report published (corrected)

Effective date: 20060112

R17D Deferred search report published (corrected)

Effective date: 20060223

REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1087012

Country of ref document: HK

R17D Deferred search report published (corrected)

Effective date: 20060112

R17D Deferred search report published (corrected)

Effective date: 20060223

A4 Supplementary search report drawn up and despatched

Effective date: 20110725

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 9/20 20060101ALI20110719BHEP

Ipc: A61K 9/48 20060101ALI20110719BHEP

Ipc: A61K 38/28 20060101AFI20110719BHEP

17Q First examination report despatched

Effective date: 20130117

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1087012

Country of ref document: HK

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20221001