EP1492447A1 - Procede et dispositif pour mesurer optiquement un gonflement du nez - Google Patents

Procede et dispositif pour mesurer optiquement un gonflement du nez

Info

Publication number
EP1492447A1
EP1492447A1 EP03722269A EP03722269A EP1492447A1 EP 1492447 A1 EP1492447 A1 EP 1492447A1 EP 03722269 A EP03722269 A EP 03722269A EP 03722269 A EP03722269 A EP 03722269A EP 1492447 A1 EP1492447 A1 EP 1492447A1
Authority
EP
European Patent Office
Prior art keywords
light
optical
nose
arrangement according
generating components
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03722269A
Other languages
German (de)
English (en)
Inventor
Uwe Hampel
Eckhard Schleicher
Eike Gunter WÜSTENBERG
Uwe Oehmichen
Karl-Bernd Hüttenbrink
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Technische Universitaet Dresden
Original Assignee
Technische Universitaet Dresden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technische Universitaet Dresden filed Critical Technische Universitaet Dresden
Publication of EP1492447A1 publication Critical patent/EP1492447A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/411—Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14552—Details of sensors specially adapted therefor

Definitions

  • the invention relates to the fields of medicine and device construction and relates to a method and an arrangement for the optical measurement of swelling of the nose, which can be used, for example, to measure nasal obstruction after allergen provocation.
  • allergic rhinitis is diagnosed by taking a symptom score (sneezing, secretion, remote symptoms such as tears in the eyes) and by measuring nasal obstruction after allergen challenge using rhinomanometry (Clement et al .: “Rhinomanometry - a review", ORL J. Otorhinolaryngol. Relat. Spec. 46, 173-91, 1984).
  • the disadvantage of rhinomanometry here is that the measurement cannot be carried out during allergen application. With severe nasal obstruction, rhinomanometry is perceived by the patient as very unpleasant. Incorrect measurements in uncooperative patients occur frequently.
  • a further possibility for determining the swelling state of the nose and in particular of the nasal mucosa is acoustic rhinometry (Fisher: “Acoustic rhinometry", Clin. Otolaryngol. 22, 307-17, 1997). These measurements have a relatively wide range of results. Adequate Accuracy is only achieved for the front sections of the nose, and none can during the measurement Medication or allergen provocation take place. A continuous measurement is not possible with this method either.
  • the object of the invention is to provide a method and an arrangement for the optical measurement of swelling conditions of the nose, with which a largely objective measurement of swelling conditions of the nose is made possible, in particular during the performance of provocation tests.
  • the arrangement according to the invention for the optical measurement of swelling states of the nose consists of a basic device with light generating components and light detection components as well as associated transmitter electronics and receiver electronics and controllers. Furthermore, at least one optical connection is realized between the basic device and an optical transmission element, the transmission of the light generated by the light generating components into the optical connection to the transmission element being implemented by optical elements. Furthermore, there is at least one optical connection between an optical receiving element and the light detection components. Outside the basic device there are transmitting and receiving elements, which are arranged on an application part. The application part realizes an arrangement of the transmitting and receiving elements that enables the light emitted by the transmitting elements to pass through the swellable tissue of at least one side of the nose to the receiving element. Furthermore, the application part can be positively applied to at least the upper part of the nose.
  • the swelling of the nasal tissue is detected optically.
  • the nasal tissue is covered from the outside with a Irradiated light source, which is emitted by a transmitting element and by a detector, a receiving element, the scattered light passing through the tissue is detected either on the same or on the opposite side of the nose.
  • the light passes through a number of layers of tissue such as the skin, muscles, mucous membrane, bones, cartilage and the airways.
  • Part of the permeated tissue is characterized by swelling ability, in particular the nasal mucosa lying above the bones of the nasal turbinates. In this part of the tissue, there is an increase in blood volume during the swelling due to the inflow of blood into the erectile tissue.
  • the inflowing blood is primarily arterial in nature and therefore normally at least 95% saturated with oxygen. Furthermore, in the event of edema possibly associated with the swelling, there is an increase in the volume of tissue water. It is therefore advantageous to carry out the irradiation spectrometrically in order to be able to measure the volume fractions of the oxygenated and deoxygenated hemoglobin and of the tissue water separately and quantitatively. This can be done either by using a white light source and a spectrometer detector (e.g. diode line spectrometer) or by using several light sources with discrete radiation spectra (LEDs, laser diodes).
  • a white light source and a spectrometer detector e.g. diode line spectrometer
  • LEDs discrete radiation spectra
  • An advantage of the arrangement according to the invention is that it is characterized by a non-invasive application from the outside and by simple handling.
  • Fig. 2 shows two variants of an application part with active transmit
  • FIG. 3 an application part and its fixation on the head and nose
  • Fig. 4 a basic device of an arrangement according to the invention
  • Fig. 5 is a schematic representation of the nose cross-section, showing the
  • FIG. 6 shows a schematic representation of the extinction measured values in the course of a
  • the arrangement according to the invention consists at least of a basic device 12 with the transmitter 15 and receiver electronics 16 required for the fulfillment of the measurement task and an application part 1 which is in direct contact with the nasal tissue during the measurement.
  • An application part 1 is shown in Fig. 1 a and b. It consists of a clasp-shaped body, the two sides of which can be positively attached to the nostrils.
  • the light-emitting element, optical transmitter element 2 is arranged on one side of the application part 1, and the light-receiving element, optical receiver element 3 is arranged on the opposite side.
  • These are either designed as discrete radiation sources and detectors, the optical axes of which are oriented in the direction of the tissue (FIG.
  • the application part 1 is fixed with the aid of a forehead carrier band 8 attached to the head. This ensures that the application part 1 is firmly positioned on the bridge of the nose during the measurement.
  • the application part is connected to the carrier tape 8 via a bracket 10.
  • the connection is designed so that an exact positioning of the application part on the bridge of the nose, e.g. B. by a lockable ball joint 9 or a flexible metal hose is possible. Further relevant variants of the arrangement according to the invention can be designed as follows:
  • the appliqué part is adhesively attached to the nose; the appliqué part is pressed directly onto the nose using an elastic band or the circumference can be adjusted to the size of the head; the appliqué part is designed as a frame similar to glasses, which sits on the root of the nose and in which the optical transmission and reception elements are pressed against the tissue of the nose by gravity;
  • the suppression and / or calibration of extraneous light influences is also important. It is therefore advantageous to use optical filters or to cover the measurement site during the measurement with an opaque cap, which, for. B. can be fixed as a plastic cap with on the carrier tape and if necessary during the examination is folded over the measuring field.
  • the basic device 12 shows a basic device 12 with device-internal light generation components 13 and light detection components 14, to which a previously described application part 1 can be connected via the optical connections 6, 7.
  • the basic device 12 consists of transmitter electronics 15 for the optical light generating components 13, receiver electronics 16 and a controller 17, to which further devices can be connected via a data interface.
  • the transmitter electronics 15 has at its output a plurality of light generating components 13, the light of which is bundled by an optical element 18. The bundled light is introduced into an optical connection 6.
  • a light detection component 14, into which light from the optical connection 7 is incident, is connected to the input of the receiver electronics 16.
  • a spectrometric measurement is advantageous for the optical measurement of swelling conditions and the differentiation of swelling causes.
  • Light sources with a limited spectrum LEDs, semiconductor lasers
  • a photodetector that is sufficiently sensitive to the selected spectral range semiconductor photodetector, photomultiplier
  • a white light source and a spectrometrically resolving detector can be used.
  • the aim of the measurement is the acquisition of light attenuation values (optical density of the tissue) at individual wavelengths of interest over time. This results from the relationship
  • ls ( ⁇ , t) denote the light intensity emitted at the transmitting element and lü ( ⁇ , t) denote the light intensity arriving at the receiving element at the wavelength ⁇ and at time t.
  • the extinction E ( ⁇ , t) is generally a function of light scattering and light absorption in tissue and thus provides a measurement for the geometric and optical change in the tissue.
  • the relationship between blood and tissue water gain can be represented.
  • special optical measurement techniques it is possible to determine the scattering and absorption properties of the tissue separately. This requires photon transit time measurements using a high-frequency modulation technique (intensity modulation of the light source (s) and amplitude and phase measurement of the receiver signal) or a pulse laser technique (application of short laser pulses and time-resolved measurement of the receiver signal).
  • a high-frequency modulation technique intensity modulation of the light source (s) and amplitude and phase measurement of the receiver signal
  • pulse laser technique application of short laser pulses and time-resolved measurement of the receiver signal.
  • the application part After preparation of the person to be examined, the application part is fixed on the bridge of the nose near the root of the nose so that the optical transmission and reception elements on the tissue face each other and the optical radiation penetrates as much swellable tissue as possible inside the nose (Fig. 5). Then a photometric signal that is as optimal as possible is set with the aid of manual, automatic or semi-automatic adjustment of source intensity (s) and / or detector sensitivity in a range suitable for the measurement by means of optomechanical, electronic and / or software technology options. The data acquisition is then started manually by the operator. Controlled by the controller 17 internal to the basic unit, there is a repeated sequential switching of the radiation sources by the transmitter electronics 15 and, at the same time, the detection of the detector measured values by the receiver electronics 16.
  • FIG. 6 schematically shows absorbance measurements in the course of a swelling.
  • the spectral light attenuation values in the unprovoked state represent the baseline of the measurement. If this is recorded in a time window of 1 to 2 minutes, an allergenic substance is administered by atomization into one or both nasal cavities and the time of measurement, e.g. B. recorded by pressing a foot switch at the time of administration tp. With an allergic reaction, swelling of the nasal tissue then begins, which causes a demonstrable increase in the spectral absorbance. 6 shows spectral extinction values, which were standardized at the start time tp for better comprehensibility. At the time t ⁇ , the swelling reaches a steady state at which no further swelling can be detected. The swelling subsides only after a time t »t E -tp. Information that can be used diagnostically can be derived from the time course of the spectral extinction values. These include in particular:
  • the increase ⁇ E ( ⁇ ) E ( ⁇ , t E ) -E ( ⁇ , t P ) of the absorbance for a wavelength as a measure of the intensity of the swelling; the extinction value difference ⁇ E ( ⁇ ) - ⁇ E ( ⁇ 2 ) at different wavelengths as a measure of the increase in the volume fractions of different tissue constituents relative to one another; the time difference the reaction from the time of provocation to the final stationary state as a measure of the swelling rate and the shape of the curves E ( ⁇ , t) as an indicator of the physiological course of the swelling.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Optics & Photonics (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

L'invention se rapporte au domaine de la construction d'appareils et concerne un procédé et un dispositif pouvant servir par exemple à mesurer l'obstruction nasale. L'objectif de l'invention est de créer un procédé et un dispositif permettant de mesurer un gonflement du nez. A cet effet, il est fait appel à un dispositif comprenant un appareil de base (12), qui présente des composants de production de lumière (13) et des composants de détection de lumière (14), ainsi que des éléments émetteurs et récepteurs (2,3) placés à l'extérieur de l'appareil de base (12), sur une partie d'application (1). A cet effet, il est également fait appel à un procédé, selon lequel : les éléments émetteurs (2) optiques envoient de la lumière ; un élément de réception (3) optique reçoit la lumière sortant du côté du nez ; les valeurs d'entrée sont enregistrées et des paramètres pouvant être exploités à des fins de diagnostic sont calculés à partir de ces dernières.
EP03722269A 2002-04-02 2003-04-01 Procede et dispositif pour mesurer optiquement un gonflement du nez Withdrawn EP1492447A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10215212 2002-04-02
DE10215212A DE10215212B4 (de) 2002-04-02 2002-04-02 Anordnung zur optischen Messung von Schwellungszuständen der Nase
PCT/DE2003/001146 WO2003082089A1 (fr) 2002-04-02 2003-04-01 Procede et dispositif pour mesurer optiquement un gonflement du nez

Publications (1)

Publication Number Publication Date
EP1492447A1 true EP1492447A1 (fr) 2005-01-05

Family

ID=28458613

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03722269A Withdrawn EP1492447A1 (fr) 2002-04-02 2003-04-01 Procede et dispositif pour mesurer optiquement un gonflement du nez

Country Status (7)

Country Link
EP (1) EP1492447A1 (fr)
JP (1) JP2005521451A (fr)
CN (1) CN1326488C (fr)
AU (1) AU2003229517A1 (fr)
CA (1) CA2480970A1 (fr)
DE (1) DE10215212B4 (fr)
WO (1) WO2003082089A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10257371A1 (de) * 2002-12-06 2004-06-24 Technische Universität Dresden Anordnung zur Messung von Schwellungen von Gewebestrukturen im Naseninnenraum
JP5147949B2 (ja) * 2008-10-30 2013-02-20 株式会社日立製作所 生体光計測装置
JP6086418B2 (ja) * 2012-03-05 2017-03-01 日本光電工業株式会社 エアウェイアダプタおよび生体情報取得システム
KR101399446B1 (ko) * 2012-09-24 2014-05-28 김승제 비염 치료용 레이저빔 조사 장치
CN103549937B (zh) * 2013-11-07 2015-03-11 中国医科大学附属第一医院 组织肿胀测量仪及其控制方法
DE102018000995A1 (de) 2018-02-08 2019-08-08 Sutter Medizintechnik Gmbh Anordnung zur quantitativen Messung der elastischen Verformung der seitlichen Nasenwand (Elastometrie)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2310315A (en) * 1940-10-07 1943-02-09 Dow Chemical Co Sodium sulphate flotation
US4830014A (en) * 1983-05-11 1989-05-16 Nellcor Incorporated Sensor having cutaneous conformance
EP0892617B1 (fr) * 1996-04-01 2001-09-19 Linde Medical Sensors AG Detection de signaux parasites lors de mesures pulsoxymetriques
US5846188A (en) * 1997-01-17 1998-12-08 Palti; Yoram Sensor utilizing living muscle cells
WO2000000080A1 (fr) * 1998-06-26 2000-01-06 Triphase Medical Ltd. Dispositif d'evaluation des proprietes du systeme de circulation sanguine
US6343224B1 (en) * 1998-10-15 2002-01-29 Sensidyne, Inc. Reusable pulse oximeter probe and disposable bandage apparatus

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO03082089A1 *

Also Published As

Publication number Publication date
JP2005521451A (ja) 2005-07-21
DE10215212B4 (de) 2004-09-23
WO2003082089A1 (fr) 2003-10-09
AU2003229517A1 (en) 2003-10-13
DE10215212A1 (de) 2003-10-30
CA2480970A1 (fr) 2003-10-09
CN1326488C (zh) 2007-07-18
CN1646054A (zh) 2005-07-27

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