EP1448255A1 - Injection device and ampoule, particularly for an injection device - Google Patents

Injection device and ampoule, particularly for an injection device

Info

Publication number
EP1448255A1
EP1448255A1 EP20020803026 EP02803026A EP1448255A1 EP 1448255 A1 EP1448255 A1 EP 1448255A1 EP 20020803026 EP20020803026 EP 20020803026 EP 02803026 A EP02803026 A EP 02803026A EP 1448255 A1 EP1448255 A1 EP 1448255A1
Authority
EP
European Patent Office
Prior art keywords
ampoule
characterized
according
injection device
carpule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP20020803026
Other languages
German (de)
French (fr)
Inventor
Karl Schulz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HNS INTERNATIONAL INC.INJEX-EQUIDYNE SYSTEMS
Original Assignee
RIEMSER Arzneimittel AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE10155784 priority Critical
Priority to DE10155770 priority
Priority to DE10155784 priority
Priority to DE10155770 priority
Application filed by RIEMSER Arzneimittel AG filed Critical RIEMSER Arzneimittel AG
Priority to PCT/EP2002/012769 priority patent/WO2003041768A1/en
Publication of EP1448255A1 publication Critical patent/EP1448255A1/en
Application status is Withdrawn legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033Spring-loaded one-shot injectors with or without automatic needle insertion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/30Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2073Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/204Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically connected to external reservoirs for multiple refilling
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic

Abstract

The injection device (10) is characterized in that it is constructed of an ampoule (12), which comprises an ampoule body (14) and an ampoule piston (16), of a filling device (18) for the ampoule (12), of a cartridge having a closed withdrawal opening (24), of a tightening device (26) for the ampoule piston (16), and of an initiating device (28) for subjecting the ampoule piston (16) to a driving force. In order to form a chamber (30) in the ampoule body (14), the ampoule piston (16) is guided while being longitudinally displaced in a sealed manner. The ampoule body (14) has a discharge opening (32) for the medium to be injected, whereby the ampoule piston (16) has a channel (34) for filling the ampoule, said channel being longitudinally guided through the ampoule piston (16). A hollow needle (36) is placed inside the channel (34) on the side of the ampoule piston (16), said side facing the cartridge (20). The closed withdrawal opening (24) of the cartridge (20) can be penetrated by the hollow needle. The filling device (18) has a pump device (38) with which a defined quantity of the medium can be forced out of the cartridge (20) and into the chamber (30), and a non-return valve (42) for automatically blocking an excess flow of the medium from the chamber (30) and into the filling device (18) is assigned to the channel (34).

Description

Injection device and ampoule in particular for an injection device

The invention relates to an injection device and a vial, in particular for an injection device, with the in the preambles of claims 1 and 37 mentioned features.

Needle-free injection devices for injecting a medium are now widely known in a large number of different more embodiments. The known devices have in common that the medium is ejected through a very small outlet opening when acted upon by high pressure, whereby a very high exit speed of the medium is achieved, which is required for a needleless hypodermic injection. In many injectors, the filling of the working chamber on the admission of the medium through the discharge aperture is effected. Due to the size of the outlet opening of this type of filling is, however, difficult to handle and time-consuming. Various embodiments of needleless injectors, therefore, have a sustained release device for the storage of the medium and a working device or ampoule as an intermediate storage for the ejection of the medium. For the purpose of filling the chamber of the vial with a metered amount of fluid from the depot facility, different mechanisms are known, their handling is also very expensive.

The invention has for its object to provide an injection device and a vial, in particular for an injection device, the generic type, which are characterized by a particularly comfortable handling.

According to the invention this object is achieved by an injection device having the features mentioned in claim 1 and a vial with those indicated in claim 37 characteristics. The injection device is characterized in that it consists of an ampoule comprising an ampoule body and an ampule piston, a Befulleinrichtung for the ampoule, carpule with closed dispensing opening, a clamping device for the ampoule plunger and a triggering device for acting on the ampoule piston with a driving force is established, wherein the ampule plunger is guided to form a chamber in the vial body to be longitudinally displaceable in a sealing, wherein the vial body has an outlet opening for the medium to be injected, wherein the ampoule plunger has a channel for filling the ampoule, which in particular longitudinally through the ampule plunger is performed, wherein a hollow needle or the like is disposed in the channel on the side facing the side of the carpule ampule piston, with which the sealed discharge opening of the carpule can be pierced, wherein the Befulleinrichtung a pumping means, or derglei- chen, with which a defined quantity of the medium from the carpule can be forced into the chamber, and wherein the channel a check valve for the independent blocking an excess current of the medium associated with the chamber in the Befulleinrichtung. By this design of the injection device is advantageously achieved in that the chamber of the vial can be filled in the ampoule piston by means of the channel. Since the channel can have a larger Durchmes- ser than the outlet opening of the vial, the chamber can be filled much faster with the provided by the carpule available medium in this way. Furthermore, it is advantageous that the medium-conducting connection see be- channel and carpule by means of the hollow needle by piercing the sealed discharge opening of the carpule is particularly easy to manufacture. With the agents, a particularly simple and comfortable handling of the injections is thus tion device achieved the ampoule is also very quick to fill.

Furthermore, in a preferred embodiment of the invention it is provided that the check valve is disposed in the channel on the side of the chamber. In this way a higher accuracy of the metering of the medium is achieved, since a after filling in the channel possibly remaining rest of the medium does not contribute to the injectable amount of medium.

Further, in a preferred embodiment of the invention provides that the injection device comprises an outer housing and particularly preferred that the ampoule body is releasably connected to the outer housing, wherein the connection is preferably a screw connection, plug connection, locking connection or suchlike. thus a particularly easy handling of the injection device is achieved advantageous, moreover, the interchangeability of the ampoule is given. Thus, the use of disposable ampoules for one-off use is for example possible.

In a preferred embodiment of the invention is also contemplated that the Befulleinrichtung comprises a receiving casing for a carpule, said receptacle housing is particularly preferably carried out in the outer housing so that the receiving housing is movable in the direction of the longitudinal axis of the ampoule. This advantageously ensures that the carpule is movable together with the ampule plunger, whereby it can retain the connection between the ampule plunger and carpule, for example, in case of multiple use of the vial. Preference is also contemplated that the on ahmegehäuse is designed in two parts, with preferential the housing case, a pot, and furthermore preferably comprises a lid. This advantageously ensures that a greater surface area of ​​the carpule to be enclosed is ahmegehäuse, whereby a greater protection of the carpule is achieved and continue towards the carpule particularly simple in the receiving housing is used. Moreover, in a preferred embodiment of the invention that the hollow needle projects beyond the ampule plunger. This ensures a particularly easy to handle Verbindungsmög- friendliness is advantageously achieved between the carpule and the channel.

In a preferred embodiment of the invention it is further provided that the carpule comprises a piston in the axial direction of the carpule movable bar. In this way, the medium can be forced very easily from the carpule. Further, it is preferably provided that the pumping device comprises a suction / pumping means, whereby the piston of the carpule is particularly easy to be driven by creating a positive or negative pressure. It is also preferable that the pump means comprises a threaded piston, with which the piston of the carpule is driven, the threaded piston is preferably carried out in particular in a longitudinally displaceable in the outer housing. Particularly preferably, it is provided that the pumping means comprises a pinion with a the thread of the piston corresponding internal thread and outer toothing which is disposed continuously on the threaded piston, the pinion preferably in a substantially fixed position relative to the receiving housing rotatably arranged is. By this arrangement, an easy-to-handle mechanism for driving the piston of the carpule is given, the threaded piston by rotation of the pinion is axially movable in both directions. , It is preferably provided also that the pinion is rotatably befes- Untitled by a connected to the outer casing or the receptacle housing by a spring or associated with the receiving housing of the carrier in substantially fixed position relative to the receiving housing. It is advantageous here that the fixing of the pinion while maintaining the rotatability is particularly easy to implement. Further, it is preferably provided that the pump means comprises a set screw with toothing, which is in the outer housing rotatably and non-displaceably mounted so that the teeth of the set screw in the outer teeth of the pinion engages. A particularly easy to handle drive way of the pinion is given by, for example, a manual rotation of the screw. The described embodiments of the pumping means comprises a high accuracy is still achieved in the metering of the medium is advantageous.

In another preferred embodiment of the invention it is provided that the accommodation housing for the carpule has a shoulder, at least, which limits the axial movement of the receptacle housing by the contact with at least one corresponding to the at least one shoulder structure of the outer housing in at least one direction. In this manner, a reference position of the carpule is given to which of the Karpullenkolben by means of the pump means for metering the medium can be relatively positioned itself. Further, a reproducible final position for carpule and ampoules flask is added at the clamping process in this way. Furthermore, in a preferred embodiment of the invention it is provided that the accommodation housing for the carpule has at least one opening for the passage of the hollow needle and / or of the threaded piston. In this way, an easy to handle access possibility of the hollow needle and / or of the threaded piston is added to the carpule.

Further, in a preferred embodiment of the invention it is provided that the clamping device comprises a drive member at least, which is particularly preferably a spring, a pneumatic cylinder, a hydraulic cylinder or the like. Hereby is given a particularly easily manageable form of energy storage for propelling the ampule piston.

Moreover, in a preferred embodiment of the invention that the clamping device comprises a counter to the force of the drive element displaceable axially led to the ampule pressure piece. Particularly preferred is provided here that the ampule piston side facing away from the outlet opening of the ampoule body has a connecting portion, the connecting portion is formed such that the connecting part with a corresponding structure of the pressure piece and / or of the receptacle housing is connectable, said Ver - bond particularly preferably non-positively, positively locking, a screw or the like. By these means, a particularly favorable force transmission from the drive element is achieved for ampoules pistons are avoided in this way damage to the ampoule piston through the pulse-like force effect of the drive element .. Furthermore.

In a preferred embodiment of the invention is also contemplated that the pressure piece is connected to the receiving housing for the carpule, wherein the compound especially preferably non-positively, positively locking, a screw or the like. This ensures that the connection between carpule and hollow needle can be maintained during the injection process, which is for multiple injections of advantage.

In a preferred embodiment of the invention it is further provided that the tensioning device comprises an actuator for driving the pressure piece, which is operatively connected to the pressure piece, as producible operative connection particularly preferably a rope drive, rack drive, toothed belt drive, form fit, force fit or the like is provided. With the aid of the actuating means is the pressure piece, for example for chip NEN of the driving element, particularly simple movable. By means of a particularly advantageous embodiments, the active compound, such as a toothed belt drive, is moreover possible a force transmission. Further, it is preferably provided that the actuating device comprises a manual actuation element, which is particularly preferably designed as a clamping lever, a hand wheel or the like. This enables a particularly simple operation of the actuator is given without the use of additional sources of energy. In addition, it is provided that the actuation device comprises a pneumatic cylinder, hydraulic cylinder, electromechanical actuator or the like. In this way, it is advantageously achieved that higher clamping forces as in the manual version of the operating element can be reached for tensioning the drive element, whereby the use of drive elements is made possible with higher driving forces.

In one embodiment of the invention is further preferably provided that said operating means comprises a carrier which is releasably connectable with a corresponding structure of the pressure piece, the pressure piece can be driven by an axial movement of the driver. In this way, the driver of the actuator can be returned to its original position after the pressure piece was placed in a clamping position provided. By a further preferably provided for operative connection between the actuating element and the carrier, which preferably is a rope, wire or suchlike, even the operating member after the clamping process is again returnable to its initial position, without that the pressure piece is moved. In addition, it is preferably provided that the carrier is connected by means of a spring with the korrespondie- Governing structure of the pressure member or with the outer housing. The spring force thus causes automatic return movement of the driver and therefore the actuating element to its original position after the end of the tightening process.

Furthermore, in a preferred embodiment of the inventions is fertil provided that the triggering device comprises a holding element for fixing the pressure member in exciting position, wherein the retaining member to release the thrust piece is particularly preferred displaceable. This advantageously given a particularly easily manageable way to provide the driving force pulsed available. Further, it is preferably provided that the release of the pressure piece is blockable by a securing means, for example against accidental release.

Moreover, in a preferred embodiment of the invention that the ampoule comprises a, the outer surface of the hollow needle completely and precisely enclosing protective tube, which in particular preferably in its length is compressible. Particular preference is also provided, sealed ampoules facing away from the piston side of the protective tube and can be pierced with the hollow needle. In this way, protection of the application is the one given DERS from injury through the hollow needle and continue a sterile handling of the fluid-carrying parts of the ampoule. Due to the compressibility of the protective tube, the sterility is ensured even during the Hersteilens the connection between carpule and hollow needle. Further, in a preferred embodiment of the invention it is provided that the ampoule body has an external thread at least, which is advantageous if a connection possibility of the ampoule body with the outer casing and / or for example with a protective cap against contamination.

It is further provided in a preferred embodiment of the invention is that the vial cap includes a protection for the outlet opening, which is releasably connected to the ampoule body. This results in a sterile handling of the vial and the fluid-carrying parts of the ampoule is given.

In a preferred embodiment of the invention is further provided that the Ampullenkόrper at least partially made of transparent material, since it is thus advantageous for the filling of the chamber of the vial can be checked. It is particularly proposed seen that the ampoule body has a measuring scale for the chamber volume, by means of which a metering of the medium is advantageous vornehmbar.

is preferably further provided that the injection means at least partially made of plastic, metal or the like, as the materials mentioned can be processed particularly favorable.

Further, in a particularly preferred embodiment of the invention it is provided that the ampule body and / or the ampoule plunger can be sterilized. By this means the possibility of multiple use of the above components can be advantageous.

Finally, the invention device is provided in a particularly preferred Ausgestal- that the check valve comprises a flexible lip. In this advantageous embodiment, the check valve is particularly simple and cost-effective manner.

The vial is characterized in that the ampoule is composed of a Ampullenkorper and an ampule piston, the ampule plunger to form a chamber in the Ampullenkorper is guided in particular in a longitudinally displaceable sealing, wherein the vial body has an outlet opening for the medium to be injected, wherein the ampule plunger having a channel for filling the ampoule, which is guided in particular longitudinally through the ampule piston, a hollow needle is arranged in the channel on the side remote from the outlet opening of the ampoule body side of the ampule piston, and wherein the channel a check valve for the independent blocking an excess current of the medium from the chamber is assigned to the channel. This design of the vial is advantageously achieved in that the chamber of the vial can be filled in the ampoule piston by means of the channel. Since the channel may have a larger diameter than the outlet opening of the ampoule, the Chamber mer can be filled in this way much more quickly with a provided media. Furthermore, it is advantageous that a medium-conducting connection between the channel and a deposition apparatus by means of the hollow needle by piercing, for example, a closed dispensing opening of the deposition apparatus is particularly simple to manufacture. With the inventions to the invention means a particularly simple and convenient handling and fillability the ampoule is thus achieved, the ampoule is also very quick to fill.

In a preferred embodiment of the invention it is provided that the hollow needle projects beyond the ampule plunger. This ensures a particularly easy to handle connectivity between a deposition apparatus and the channel is advantageously achieved.

Further, in a preferred embodiment of the invention it is provided that the ampoule body has an external thread at least, thereby advantageously ektionseinrichtung a connection possibility of the ampoule body with a Inj and / or for example with a protective cap against contamination, is given.

Furthermore, in a preferred embodiment of the invention it is provided that the ampule body at least partially made of transparent material, since it is thus advantageous for the filling of the chamber of the vial can be checked. It is particularly provided that the ampoule body has a measuring scale for the chamber volume, by means of which a metering of the medium is advantageous vornehmbar. In addition, it is preferably provided that the ampule at least partially made of plastic, metal or the like, as the materials mentioned can be processed particularly favorable.

In a particularly preferred embodiment of the invention it is provided that the ampule body and / or the ampoule plunger can be sterilized. In this way, the possibility of multiple use of the above components can be advantageous.

Further, in a preferred embodiment of the invention it is provided that the ampule plunger facing away from the outlet opening of the ampoule body side has a connecting portion, the connecting portion is formed such that the connecting part with a corresponding structure of, in particular a drive device is connectable, wherein 'in particular the compound is preferably force fit, form fit, a screw connection or the like. By these means, a particularly favorable force transmission from the drive element is achieved for cartridge plunger. Furthermore, damage to the ampoule piston be avoided by, for example, a pulse-like force of the drive means in this way.

Further, in a preferred embodiment of the

Invention provided that the vial cap includes a protection for the outlet opening, which is releasably connected to the ampoule body. This results in a sterile handling of the vial and the fluid-carrying parts of the ampoule is given.

Moreover, in a preferred embodiment of the invention that the ampoule comprises a, the outer surface of the hollow needle completely and precisely enclosing protective tube, which is compressible preferably in particular its length. Particular preference is also provided, sealed ampoules facing away from the piston side of the protective tube and can be pierced with the hollow needle. In this way, a user protection against injury through the hollow needle and continue a sterile handling of the vial and the fluid-carrying parts of the vial is the one given. Due to the compressibility of the protective tube, the sterility is ensured even during the Hersteilens the connection between carpule and hollow needle.

In a particularly preferred embodiment of the invention it is provided that the check valve comprises a flexible lip. In this advantageous embodiment, the check valve is particularly simple and cost-effective manner.

Finally, in a preferred embodiment of the invention it is provided that the check valve is disposed in the channel on the side of the chamber. In this way a higher accuracy of the dosing is achieved tion of the medium, as a possibly after filling in the channel remaining rest of the medium does not contribute to the injectable amount of medium. Further preferred embodiments of the invention emerge from the other, referred to in the subclaims.

The invention will now be described in embodiments with reference to the accompanying drawings. Show it:

Figure la an injection device with ampoule

Carpule, Befulleinrichtung, chuck and release device

Figure lb, the injection device in the tensioned state;

Figure 2 is a pumping means for filling the vial;

3a shows the injection device in side view;

3b shows the injection device in a side view in the tensioned state;

4 shows a non-return valve and

5 shows an ampoule with a piston and hollow needle protection sleeve.

Figure la and lb show schematically an embodiment of an injection apparatus 10 according to the invention with ampoule 12, carpule 20, Befulleinrichtung 18, tensioning means 26 and release means 28 in the relaxed (Figure la) and tensioned (Figure lb) state. The vial 12 is made of a vial body 14 and constructed in a longitudinally displaceable sealingly guided in the ampoule body 14 ampoules piston 16, a channel 34 longitudinally through the ampule plunger 16 therethrough extends through which a retracted, out of the ampoule body 14 ampoules piston 16 in the cartridge body 14 formed chamber 30 is filled with a medium to be injected. The vial body 14 has an outlet opening 32 through which the medium is discharged during the injection '. The ampule piston 16 has on its Austrittsoff- the voltage 32 on the side facing a check valve 42 which prevents overflow of fluid from the chamber 30 back into the channel 34th At the exit end of the ampoule body 14, a protective cap is detachably secured by a screw 76 to ensure a sterile handling of the ampoule 12th By means of a second screw, the opposite end of the ampoule body 14 is releasably connected to an outer casing 46, thereby giving a simple exchange ability of the vial 12, for example for the use of vials 12 to a single use. On the side opposite the exit opening side of the ampoule piston 16, a hollow needle 36 is connected to the channel 34th An initially closed dispensing opening 24 of an axially disposed behind the ampule plunger 16 carpule 20 of a Befulleinrichtung 18 having a to be injected medium was pierced by means of the hollow needle 36, so that the medium can flow through the hollow needle 36 into the channel 34 of the ampoule 12th The carpule 20 facing toward the end of the ampoule piston 16 has a connecting part which is releasably positively connected with a pressure piece 54th Thereby, the ampule plunger 16 is carried along at a movement of the pressure piece 54, as shown in Figure lb. The carpule 20 is in a two-part receptacle housing 48 having a receiving pot and a lid with an opening for the passage of the hollow needle 36, which is guided longitudinally displaceably in the outer casing 46th The receiving housing 48 is connected to the pressure piece 54, so that the carpule 20 and the ampule plunger 16 in equal measure 54 are entrained with the pressure piece 54 with movement of the thrust piece. The carpule 20 has a piston 22, with which the medium contained in the carpule 20 of the carpule 20 into the hollow needle 36 and the vial piston 16 can be forced. Through an opening of the receptacle of assembly acquisition housing 48 a threaded piston 40 is guided a pumping device 38, by means of which the piston 22 of the carpule is drivable 20th The threaded piston 40 is guided longitudinally displaceably in the outer casing 46th With the help of a tensioning device 26, indicated by a clamping lever 68, the pressure piece can advertising taken 54 together with the entrained ampule plunger 16 and the carpule 20 from a first position (figure la) in a second position (Figure lb) the in which the thrust piece 54 engages. The first position (Figure la) is characterized in that the pressure piece 54 is in its end position close to the ampoule 12, so that the ampule plunger 16 to the ampoule body 14 completely fills with inserted ampoule 12th If an ampoule is screwed into this position of the pressure member 54 in inserted carpule 20 12 in the outer housing 46 so 36 16 pierces the hollow needle of the ampule piston, the discharge opening 24 of the carpule 20 during the screwing operation, so that a medium-carrying connection between the vial 12 and carpule 20 produced becomes. The second position is characterized (Figure lb) is characterized in that the pressure piece 54 engages in the triggering device 28th In this position, the receptacle housing 48 of the carpule 20 is in an end position, which zes by the touch of a Absat- of the receptacle housing 48 is marked with a corresponding structure of the outer housing 46th Thus a reproducible clamping position is given. In this position, the entrained with the pressure piece 54 ampoules piston 16 from the ampoule body 14 protrudes so that a chamber in the vial body 14 is 30, which is filled with the medium. For this purpose, the threaded piston 40 is moved into the carpule 20 so that the piston 22 of the carpule 20 is verla- siege by means of the threaded piston 40, whereby a portion of the medium from the carpule 20 into the hollow needle 36, through the channel 34 and the check valve 42 is passed forced into the chamber 30 of the ampoule 12th A defined quantity of the medium here is dosed by means of a not th dargestell- attached to the cartridge plunger 16 scale for the chamber volume. By actuation of the trigger device 28 may be released 54 now the pressure piece, whereby the pressing piece 54 vorschnellt together with the carpule 20 and the ampule plunger 16 and the medium back through the outlet orifice 32 under high pressure from the chamber 30 is expelled through. The pressure element 54 is now back in its first position (Figure la).

2 shows an embodiment of a Befulleinrichtung 18 of the injection device 10 of the invention is shown schematically. With the aid of a pump means 38, a defined quantity of a medium from the carpule 20 disposed in a carpule 20 can be forced. The pumping means 38 consists of a threaded piston 40 which is screwed into the corresponding female thread of a pinion 64th The pinion 64 is pressed to the receiving housing 48 of the carpule 20 by means of a pressure spring 62, whereby the pinion 64 is held in a fixed position relative to the receiving housing 48th With a rotation of the pinion 64 hence the threaded piston is moved axially 40 through the screw connection between the pinion 64 and threaded piston 40th The threaded piston 40 contacts with its end face a piston 22 located in the carpule 20 so that the plunger 22 is advanced during an axial movement of the threaded piston 40 to the carpule 20. through the threaded piston 40, which pushed a defined quantity of the medium from the carpule 20 becomes. The pinion 64 is provided with an outer toothing, in which engages the toothing of an adjusting screw 66, with which the pinion 64 is driven. The set screw 66 is not displaceably mounted rotatably in an outer casing 46th For example, by a manual rotation of the adjustment screw 66, a defined quantity of the medium from the carpule 20 into, for example, connected to said carpule 20 ampoule 12 is thus dosed.

Figure 3a and 3b show schematically an embodiment of the clamping device 26 and the trigger device 28 of an injection apparatus 10 according to the invention in side view in the relaxed (Figure 3a) and stretched (Figure 3b) state. The clamping device 26 comprises a pre-stressed drive spring 50 which is connected to an outer housing 46 and a pressure piece 54 and a clamping lever 68, which is connected via a cable 60 with a driver 56th The driver 56 is connected via a return spring 52 with the pressure piece 54th The release device 28 comprises a displaceable supporting element 70 and a securing means 72. In the relaxed state (Figure 3a) is located in the thrust piece 54 in a first position. On actuation of the tensioning lever 68 of the driver 56 through the connection cable 60 with the cocking lever 68 is moved in the direction of tensioning lever 68th Upon contact with a corresponding cam 56 with the structure 58 of the pressure element 54 the pressure member 54 is moved by the driver 56 against the spring force of the drive spring 50, until the pressure member 54 in a second position

(Figure 3b). The second position (Figure 3b) is characterized by the engagement of a retaining element 70, through which a movement of the thrust piece 54 BLO back to the first position is ckiert. By the spring force of the connected to the pressure piece 54 and the driver 56 return spring 52 tang 56 and tension levers 68 are pressed back into their starting position. During a displacement of the holding element 70, the pressure piece can be released 54th By the spring force of the drive spring 50 the pressure piece 54 is moved once again at high speed in the first position (Figure 3a). By means of a securing device 72, a displacement of the holding element 70 and thus the release of the pressure element 54 can be blocked. In this way, the triggering device can be secured 28 against accidental firing. The pressure element 54 is connected to an ampule plunger 16 so that an ampoule An in-12th Medium may be ejected by the drive of the ampoule piston 16 by means of the clamping device 26 under high pressure from the vial 12th

Figure 4 schematically shows the construction of the embodiment of a connected with a channel 34 of a vial piston 16 check valve 42 of the injection device according to the invention 10. The check valve 42 consists essentially of a flexible transverse to the longitudinal direction of the ampoule piston 16 disposed lip 44 which on one side with the ampule plunger 16 is connected. The ampule piston 16 is longitudinally displaceably guided in a sealed ampoule body fourteenth At an overpressure in one of the ampoule body 14 and ampule plunger 16 formed chamber 30 relative to the pressure in the channel 34 of the ampoule piston 16, the lip 44 is pressed with its free end against the ampule plunger sixteenth In this manner, the channel 34 is sealed, thereby can flow not situated in the box 30 medium back into the channel 34th At an overpressure in the channel 34 relative to the pressure in the chamber 30, the lip 44 is pressed in the direction of chamber 30, and an inflowing medium may pass unimpeded the check valve 42nd

In Figure 5, the end of an ampoule piston 16 with the hollow needle 36 and protective tube 74 is schematically illustrated. The hollow needle 36 is fixedly connected to an extending longitudinally through the cartridge plunger 16 channel 34th The protective tube 74 surrounds the outer surface of the hollow needle 36 is completely and accurately. In this way, protecting the user is the one given against injury through the hollow needle 36th In particular, a simple sterile handling of the hollow needle 36 is possible through the use of a protective tube 74th By a flexible design of the protective tube 74 of this can also remain during the making of a connection between the hollow needle 36 and a Befulleinrichtung 18 on the hollow needle 36th During the penetration of the hollow needle 36 in, for example, a carpule 20 of the protective tube 74 is pushed together. Thus, the sterility of the hollow needle 36 even during the Hersteilens the connection is ensured. LIST OF REFERENCE NUMBERS

10 injection device

12 ampoule

14 ampoule body 16 ampule plunger

18 Befulleinrichtung

20 carpule piston 22 with medium

24 discharge opening 26 clamping device

28 triggering device

30 chamber

32 outlet opening

34 channel 36 hollow needle

38 pump device

40 threaded piston

42 check valve

44 flexible lip 46 outer housing

48 accommodating case for a carpule 50 drive spring

52 return spring

54 spacer 56 driver

58 corresponding structure

60 cable pressure spring screw pinion with toothed clamping lever holding member securing device protective tube cap

Claims

claims
1. Injection device (10) for injection of a medium with an ampoule (12) comprising a vial body (14) and an ampoule plunger (16), a Befulleinrichtung (18) for the ampoule (12), a carpule (20) closed dispensing opening (24), a clamping device (26) for the ampoule plunger (16) and a triggering device (28) for acting on the ampoule piston (16) with a driving force, wherein
- the ampoule plunger (16) to form a chamber (30) in the ampoule body (14) is in particular longitudinally displaceably guided sealingly,
- the ampoule body (14) an outlet opening
(32) for having medium to be injected,
- the ampoule plunger (16) has a channel (34) for filling the vial (12), which in particular longitudinally through the ampule plunger (16) is guided,
- a hollow needle (36) or the like in the channel (34) on the side facing the carpule (20) of the ampoule plunger (16) is arranged, with which the closed discharge opening (24) of the carpule (20) can be pierced,
- the Befulleinrichtung (18) comprises a pump means (38) or the like, with which a defined quantity of the medium from the carpule (20) into the chamber (30) can be forced and
- the channel (34) a check valve (42) for self-locking of an overcurrent of the
Medium from the chamber (30) in the Befulleinrichtung is assigned (18).
2. The injection device (10) according to claim 1, characterized in that the check valve
(42) in the channel (34) is arranged on the side of the chamber (30).
3. The injection device (10) according to one of Ansprü- before 1 to 2, characterized in that the injection device (10) comprises an outer housing (46).
4. The injection device (10) according to claim 3, characterized in that the ampoule body (14) with the outer casing (46) is releasably connectable.
5. The injection device (10) according to claim 4, characterized in that the connection is a screw connection, plug connection, locking connection or the like.
6. The injection device (10) according to one of claims 1 to 5, characterized in that the Befulleinrichtung (18) comprises a receptacle housing (48) for a carpule (20).
7. The injection device (10) according to claim 6, characterized in that the receiving housing (48) for the carpule (20) in the outer casing (46) is performed such that the receiving housing (48) processing in the direction (the longitudinal axis of the ampoule 12) is movable.
8. The injection device (10) according to any one of claims 6 to 7, characterized in that the receiving housing (48) for the carpule (20) comprises a receiving pot.
9. The injection device (10) according to any one of claims 6 to 8, characterized in that the receiving housing (48) for the carpule (20) comprises a lid.
.
10. The injection device (10) according to one of claims 1 to 9, characterized in that the hollow needle (36) on the ampoule piston (16) protrudes.
11. The injection device (10) according to one of claims 1 to 10, characterized in that the carpule (20) comprises a piston (22) which is movable in the axial direction of the carpule (20).
12. The injection device (10) according to any one of claims 1 to 11, characterized in that the pump means (38) comprises a suction / pumping means with which the piston (22) of the carpule (20) by pressurization and / or depressurization can be driven.
13. In ektionseinrichtung (10) according to claim 11, characterized in that the pump means (38) includes a threaded piston (40) with which the piston (22) of the carpule (20) is drivable.
14. The injection device (10) according to claim 13, characterized in that the threaded piston (40) in particular longitudinally displaceable in the outer housing is performed (46).
15. The injection device (10) according to any one of claims 13 to 14, characterized in that the pump means (38) (64) comprises a pinion with a the thread of the threaded piston (40) corresponding internal thread and outer toothing, which (on the threaded piston 40) is disposed continuously.
16. The injection device (10) according to claim 15, characterized in that the pinion (64) megehäuse in a substantially fixed position relative to the Aufnah- (48) is rotatably arranged.
17. The injection device (10) according to claim 16, characterized in that the pinion (64) connected by a with the outer housing (46) or the receiving housing (48) connected to the spring (62) or by a with the receiving housing (48) driver is rotatably mounted in the substantially fixed position relative to the receiving housing (48).
18. The injection device (10) according to one of Ansprü- before 13 to 17, characterized in that the pump means (38) comprises a screw (66) with teeth which is rotatably and non-displaceably mounted so in said outer housing (46) that engages the toothing of the adjusting screw (66) in the outer toothing of the pinion (64).
19. The injection device (10) according to any one of claims 6 to 18, characterized in that the receiving housing (48) for the carpule (20) has a shoulder at least said axial movement of the receiving housing (48) by contact with at least one of limited the corresponding at least one shoulder of the outer housing structure (46) in at least one direction.
20. The injection device (10) according to any one of claims 6 to 19, characterized in that the receiving housing (48) for the carpule (20) at least one opening for the passage of the hollow needle (36) and / or of the threaded piston (40).
21. The injection device (10) according to one of claims 1 to 20, characterized in that the tensioning device (26) comprises at least one drive element.
22. The injection device (10) according to claim 19, characterized in that the drive element is a spring (50), a pneumatic cylinder, a hydraulic cylinder or the like.
23. The injection device (10) according to any one of claims 21 to 22, characterized in that the tensioning device (26) comprises a displaceable against the force of the driving element axially relative to the ampoule (12) run pressure piece (54).
24. The injection device (10) according to claim 23, characterized in that the ampoule plunger (16) at its exit opening side facing away (32) of Ampullenkör- pers (14) having a connecting portion, the connecting portion is formed such that the connecting member having a corresponding structure of the pressure piece (54) and / or drive means and / or the Aufnahmegehäu- ses (48) is connectable.
25. The injection device (10) according to any one of claims 23 to 24, characterized in that the pressure piece (54) to the receiving housing (48) for the carpule (20) is connectable.
26. The injection device (10) according to any one of claims 24 to 25, characterized in that at least one of the compounds is force-fit, form-fit, a screw connection or the like.
27. The injection device (10) according to one of claims 23 to 26, characterized in that the tensioning device (26) comprises an actuator for driving the pressure piece (54) which is operatively connected to the pressure piece (54).
28. The injection device (10) according to claim 27, characterized in that the operative connection through a cable drive (60), rack and pinion, toothed belt drive, form fit, frictional connection, a spring or the like is manufactured.
29. The injection device (10) according to any one of claims 27 to 28, characterized in that the unauthorized activation means comprises a driver (56) coupled to a corresponding structure (58) of the pressure piece (54) is detachably connectable, wherein the pressure piece ( 54) can be driven by an axial movement of the driver (56).
30. The injection device (10) according to any one of claims 27 to 29, characterized in that said operating means comprises a manual actuator.
31. An injection device according to claim 30, characterized in that the actuating element is a tension lever (68), hand wheel or the like.
is operatively connected to the injection device 32. (10) according to any one of claims 30 to 31, characterized in that the beta-actuating element with the driver (56).
33. The injection device (10) according to claim 32, characterized in that the active compound is a
Rope (60), wire, or the like.
34. The injection device (10) according to any one of claims 29 to 33, characterized in that the co-contractor (56) by means of a spring (52) with the corresponding structure (58) of the pressure piece (54) or with the outer casing (46) connected is.
35. The injection device (10) according to one of Ansprü- before 27 to 34, characterized in that the actuating device comprises a pneumatic cylinder, hydraulic cylinder, electromechanical actuator or the like.
36. The injection device (10) according to any one of claims 23 to 35, characterized in that the triggering device (28) comprises a holding element (70) for fixing the pressure member (54) in exciting position.
37. The injection device (10) according to claim 36, characterized in that the holding element (70) for releasing the pressure piece (54) is displaceable.
38. The injection device (10) according to claim 37, characterized in that the release of the pressure piece (54) by a securing device (72) is blocked.
39. The injection device. (10) according to one of Ansprü- before 1 to 38, characterized in that
Ampoule (12) comprises, the outer surface of the hollow needle
includes (36) completely and accurately surrounding protective hose (74).
40. The injection device (10) according to claim 39, characterized in that the protective tube (74) is compressible in length.
41. The injection device (10) according to one of Ansprü- before 39 till 40, characterized, in that the
Ampoules piston (16) remote side of the protective
Tube (74) closed and with the hollow needle
(36) can be pierced.
42. The injection device (10) according to any one of claims 1 to 41, characterized in that the ampoule body (14) has at least one external thread.
43. The injection device (10) according to one of Ansprü- before 1 to 42, characterized in that the ampoule body (14) at least partially consists of transparentem- material.
44. The injection device (10) according to claim 43, characterized in that the ampoule body (14) has a measuring scale for the chamber volume.
45. The injection device (10) according to any one of claims 1 to 44, characterized in that the injection device (10) at least partly consists of plastic, metal or the like.
46. ​​The injection device (10) according to any one of claims 1 to 45, characterized in that the ampoule body (14) and / or the ampoule plunger (16) is sterilizable.
47. The injection device (10) according to one of claims 1 to 46, characterized in that the check valve (42) has a flexible lip (44).
48. The injection device (10) according to any one of claims 1 to 47, characterized in that the ampoule (12) comprises a protective cap (76) for the outlet opening (32) which is releasably connected to the ampoule body (14).
49. ampoule (12) for the injection of a medium having ampoule body (14) and ampule plunger (16), wherein
- the ampoule plunger (16) to form a chamber (30) in the ampoule body (14) is in particular longitudinally displaceably guided sealingly,
- the Ampullenkorper (14) has an outlet opening (32) for the medium to be injected, - the ampoule plunger (16) has a channel (34) for filling the vial (12), which in particular longitudinally through the ampule plunger (16) is guided,
- a hollow needle (36) in the channel (34) on which the outlet opening (32) of the ampoule body
(14) side facing away from the ampoule plunger (16) is arranged and
- associated with the channel (34) a check valve (42) for self-locking of an overcurrent of the medium from the chamber (30) into the channel (34).
50. ampoule (12) according to claim 49, characterized in that the hollow needle (36) on the ampoule piston (16) protrudes.
51. ampoule (12) according to any one of claims 49 to 50, characterized in that the ampoule body (14) has at least one external thread.
52. ampoule (12) according to any one of claims 49 to 51, characterized in that the Ampullenkorper (14) at least partially made of transparent material.
53. ampoule (12) according to claim 52, characterized thereby marked, that the ampoule plunger (16) and / or the
Ampoule body (14) has a measuring scale for the chamber volume.
54. ampoule (12) according to any one of claims 49 to 53, characterized in that the ampoule (12) at least partially made of plastic, metal or derglei- chen is.
55. ampoule (12) according to any one of claims 49 to 54, characterized in that the ampoule body (14) and / or the ampoule plunger (16) is sterilizable.
56. ampoule (12) according to any one of claims 49 to 55, characterized in that the ampoule plunger (16) at its exit opening (32) of the ampoule body (14) side facing away from a connecting portion, the connecting portion is formed such that the connecting part with a corresponding structure of, in particular a drive device is connectable.
57. ampoule (12) according to claim 56, characterized in that the connection is form-fitting, force-fitting, a screw or the like.
58. ampoule (12) according to any one of claims 49 to 57, characterized in that the check valve (42) in the channel (34) is arranged on the side of the chamber (30).
59. ampoule (12) according to any one of claims 49 to 58, characterized in that the check valve (42) has a flexible lip (44).
60. ampoule (12) according to any one of claims 49 to 59, characterized in that the ampoule (12) comprises a protective cap (76) for the outlet opening (32) which is releasably connected to the ampoule body (14).
comprises 61. ampoule (12) according to any one of claims 49 to 60, characterized in that the ampoule (12) comprises, the outer surface of the hollow needle (36) completely and precisely enclosing protective tube (74).
62. ampoule (12) according to claim 61, characterized in that the protective tube (74) is compressible in length.
63. ampoule (12), characterized in any one of claims 61 to 62 that the ampule plunger
concluded remote (16) side of the protective tube (74) locked and with the hollow needle (36) is pierced.
EP20020803026 2001-11-14 2002-11-14 Injection device and ampoule, particularly for an injection device Withdrawn EP1448255A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE10155784 2001-11-14
DE10155770 2001-11-14
DE10155784 2001-11-14
DE10155770 2001-11-14
PCT/EP2002/012769 WO2003041768A1 (en) 2001-11-14 2002-11-14 Injection device and ampoule, particularly for an injection device

Publications (1)

Publication Number Publication Date
EP1448255A1 true EP1448255A1 (en) 2004-08-25

Family

ID=26010573

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20020803026 Withdrawn EP1448255A1 (en) 2001-11-14 2002-11-14 Injection device and ampoule, particularly for an injection device

Country Status (3)

Country Link
EP (1) EP1448255A1 (en)
DE (1) DE10253637A1 (en)
WO (1) WO2003041768A1 (en)

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GB2414402B (en) 2004-05-28 2009-04-22 Cilag Ag Int Injection device
GB2414400B (en) 2004-05-28 2009-01-14 Cilag Ag Int Injection device
GB2414775B (en) 2004-05-28 2008-05-21 Cilag Ag Int Releasable coupling and injection device
GB2414403B (en) * 2004-05-28 2009-01-07 Cilag Ag Int Injection device
GB2425062B (en) 2005-04-06 2010-07-21 Cilag Ag Int Injection device
GB2424836B (en) 2005-04-06 2010-09-22 Cilag Ag Int Injection device (bayonet cap removal)
US20110098656A1 (en) 2005-09-27 2011-04-28 Burnell Rosie L Auto-injection device with needle protecting cap having outer and inner sleeves
GB2438591B (en) 2006-06-01 2011-07-13 Cilag Gmbh Int Injection device
GB2461085B (en) 2008-06-19 2012-08-29 Cilag Gmbh Int Injection device

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Also Published As

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DE10253637A1 (en) 2003-11-06

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