EP1446172A2 - Adaptateurs destines a des inhalateurs pour ameliorer les performances - Google Patents

Adaptateurs destines a des inhalateurs pour ameliorer les performances

Info

Publication number
EP1446172A2
EP1446172A2 EP02761817A EP02761817A EP1446172A2 EP 1446172 A2 EP1446172 A2 EP 1446172A2 EP 02761817 A EP02761817 A EP 02761817A EP 02761817 A EP02761817 A EP 02761817A EP 1446172 A2 EP1446172 A2 EP 1446172A2
Authority
EP
European Patent Office
Prior art keywords
adaptor
mouthpiece
inhaler
inhalation
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP02761817A
Other languages
German (de)
English (en)
Other versions
EP1446172A4 (fr
EP1446172B1 (fr
Inventor
Andrew L. Abrams
Anand V. Gumaste
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microdose Therapeutx Inc
Original Assignee
Microdose Therapeutx Inc
Microdose Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microdose Therapeutx Inc, Microdose Technologies Inc filed Critical Microdose Therapeutx Inc
Publication of EP1446172A2 publication Critical patent/EP1446172A2/fr
Publication of EP1446172A4 publication Critical patent/EP1446172A4/fr
Application granted granted Critical
Publication of EP1446172B1 publication Critical patent/EP1446172B1/fr
Priority to CY20101100599T priority Critical patent/CY1110147T1/el
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/1005—Preparation of respiratory gases or vapours with O2 features or with parameter measurement
    • A61M16/101—Preparation of respiratory gases or vapours with O2 features or with parameter measurement using an oxygen concentrator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
    • A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
    • A61M2016/0039—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical in the inspiratory circuit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/18—General characteristics of the apparatus with alarm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A61M2205/3334—Measuring or controlling the flow rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/43—General characteristics of the apparatus making noise when used correctly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • A61M2205/584—Means for facilitating use, e.g. by people with impaired vision by visual feedback having a color code

Definitions

  • the present invention relates generally to the field of inhalation devices, and more specifically, to a mouthpiece adaptor and patient feedback for an inhaler.
  • the invention has particular utility as a mouthpiece adaptor and patient feedback for inhalation devices such as dry powder inhalers ("DPIs") for facilitating use of same by pediatric, geriatric and compromised patients, and will be described in connection with such utility, although other utilities are contemplated such as for use with metered dose inhalers (“MDIs”) and nebulizers.
  • DPIs dry powder inhalers
  • MDIs metered dose inhalers
  • MDIs metered dose inhalers
  • a properly delivered MDI medication depends on dexterity, coordination, timing, and practice.
  • DPIs dry powder inhaler devices
  • the drug is aerosolized by the airflow through a DPI created by the patient inhaling.
  • DPI devices are easy to use and are thus suitable for most ages.
  • Newer multidose types of powder devices have electronics which include dose counters, which enable patients to check whether or not they have taken a dose and warns them when the inhaler is running out of doses by showing them exactly how many doses remain.
  • An inhalation chamber typically includes an inlet and fixture for a medicament dispenser, e.g., an MDI, and an expanded hollow body, which in the technical field of inhalers normally is called a "spacer" or inhalation chamber, having an outlet provided at the end remote from the inlet.
  • a medicament dispenser e.g., an MDI
  • an expanded hollow body which in the technical field of inhalers normally is called a "spacer" or inhalation chamber, having an outlet provided at the end remote from the inlet.
  • An inhalation/exhalation valve typically is provided adjacent the outlet, and a mouthpiece is provided at the outlet.
  • a mouthpiece is provided at the outlet.
  • the mouthpiece is inserted between the teeth and the lips are closed around the mouthpiece. It is, however, not possible for young children and infants to hold such a mouthpiece between their lips.
  • these devices are constructed to be used by older children who have large lung capacity and who can inhale more forcefully.
  • the inhalation/exhalation valves provided typically require a certain inhalation flow, which a child or infant is unable to generate, to open properly. Therefore, for satisfactory inhalation to be achieved by young children and infants, inhalation devices often are provided with a face mask.
  • Nebulizers produce a cloud of medication by passing a jet of compressed air through a solution of a drug (jet nebulizers) or by dropping the drug solution onto a plate vibrating at high frequency (ultrasonic nebulizers).
  • Jet nebulizers a solution of a drug
  • ultrasonic nebulizers ultrasonic nebulizers
  • Nebulizers have the advantage of being able to be used by patients of all ages, including young babies, because coordination is unimportant.
  • disadvantages of nebulizers include that they are cumbersome, expensive (both the machine and the drugs) and noisy; require a power source, typically lines (AC) current; treatment takes a long time, often around ten minutes; and young patients are required to wear a mask.
  • the amount of drug delivered to the lungs is highly dependant on the breathing pattern of the patient.
  • nebulizers have the above problems, several devices have been developed in order to entice or teach children how to use MDIs or DPIs, so that a nebulizer is unnecessary. But, those devices designed for use by young children require a mask adaptor for the MDI or DPI.
  • PCT Application No. 995398 to Watt and European Patent 667168 to Minar et al. disclose incentive systems of this type. Quite apart from the foregoing, conventional MDIs and DPIs (and also inhalation chambers therefor) have mouthpieces sized for the adult population.
  • conventional MDIs, DPIs and inhalation chambers therefor have mouthpieces that are too big to be comfortably used by small children and infants.
  • the mouthpieces of conventional MDIs, DPIs and spacers are primarily rectangular in shape, which is somewhat awkward, or at least unfamiliar, particularly to small children.
  • This invention seeks to solve the problems with the prior art by allowing young children, geriatric and compromised patients to use DPIs, MDIs and inhalation chambers mask-free.
  • Another aspect of the invention seeks to solve the issue of consistent patient inhalation in the pediatric, geriatric or physically challenged patients.
  • Another aspect of the invention seeks to solve the problem of patient compliance when the patient is young, thereby enabling them to use certain devices previously unavailable to them.
  • Figure 1 is a longitudinal view of an exemplary adaptor for an inhaler attached to an inhaler according to one embodiment of the invention
  • Figure 2 is a longitudinal view of an exemplary adaptor for an inhaler attached to an inhaler according to another embodiment of the invention
  • Figure 3 is a longitudinal view of an exemplary adaptor for an inhaler attached to an inhaler according to yet another embodiment of the invention
  • Figure 4 is a frontal view of an exemplary adaptor for an inhaler and a mouthpiece for an adaptor according to one embodiment of the invention
  • Figure 5 is a frontal view of an exemplary adaptor for an inhaler and the mouthpiece of the adaptor according to another embodiment of the invention
  • Figure 1 is a longitudinal view of an exemplary adaptor for an inhaler attached to an inhaler according to one embodiment of the invention
  • Figure 3 is a longitudinal view of an exemplary adaptor for an inhaler attached to an inhaler according to yet another embodiment of the invention
  • Figure 4 is a frontal view of an exemplary adaptor
  • Figure 1 illustrates one embodiment of an exemplary adaptor, wherein an adaptor 1 is attached to the mouthpiece 10 of an inhaler 5.
  • the adaptor is attached to the inhaler mouthpiece 10 from an attachment side 2 using an attachment means that forms an airtight seal.
  • the adaptor side is designed to create a friction fit with the inhaler mouthpiece.
  • the friction fit is accomplished by creating the attachment side of the adaptor to be just slightly larger in inside dimension than the outside dimension of the inhaler mouthpiece to which it is designed to attach, and sliding the adaptor onto the inhaler mouthpiece, thereby creating an airtight seal.
  • the adaptor 1 also includes a transition section 4 between a mouthpiece side 3 and an attachment side 2.
  • the transition section 4 tapers the attachment side 2 of the adaptor to a child-sized mouthpiece side. Aerated particles enter and immediately pass through the connection means from the inhaler mouthpiece upon proper stimulation of the inhalation device.
  • the connecting means does not act as a holding chamber.
  • connection means is tapered in a funnel-like shape to minimize turbulence and prevent the coagulation of the aerated particles upon usage of the adaptor, which helps maintain the inhaler's effectiveness.
  • the mouthpiece side 3 is child-sized, similar in cross-sectional dimension to that of a drinking straw, i.e., having a diameter in the range of 1mm to 15mm, and is either round or oval shaped, as shown in Figure 4.
  • a round shape for the mouthpiece side is preferred for young children who are already familiar with this shape, i.e., from the use of drinking straws. That is to say, young children are already familiar with using a straw, and have shown that they are capable of proper inspirator pressures.
  • FIG. 2 A second embodiment of mouthpiece adaptor 4 is illustrated in Figure 2.
  • This embodiment like the first, includes a connecting side 21, a transition section 6, and a mouthpiece side 3.
  • the connecting side 21 must facilitate the formation of an airtight seal. As shown in Figure 2, this is accomplished by securing a plastic or metal clamp 20, which is located on the connecting side 21 of the mouthpiece adaptor.
  • the mouthpiece adaptor attachment side 21 is larger in inside dimension than the outside dimension of the inhaler mouthpiece 10, and allows the adaptor to easily slide on the inhaler mouthpiece 10.
  • the mouthpiece adaptor of Figure 2 includes a funnel-like region between the connecting side 21 and the mouthpiece side 3 comprising a slanted wall 7 formed opposite of the inhaler mouthpiece.
  • a metal foil 6 is applied to the slanted wall connected to the circuit of the MDI or DPI and charged by the power source of the MDI or DPI, to the same charge as the particles. This causes a repulsion between the slanted wall and the particles whereby to prevent the particles from collecting on or colliding with the wall, and thus prevent coagulation of the particles on the interior adaptor walls.
  • aerated particles only enter and pass through the adaptor of Figure 2 upon proper stimulation of the inhalation device, i.e., the connection means does not act as a holding chamber.
  • the mouthpiece side of the adaptor of Figure 2, as illustrated in Figure 5, is manufactured as a replication of the inhaler mouthpiece.
  • the mouthpiece side in the adaptor of Figure 2 is child-sized, i.e.,
  • FIG. 3 A third embodiment of the instant invention is shown in Figure 3.
  • the third embodiment like the first and second, includes a connecting side 2, a transition section 4, and a mouthpiece side 3.
  • the connecting side 2 is fitted to the inhaler mouthpiece 10 using an attachment means that employs a rubber ring to create an airtight seal.
  • the connecting side 2 is slightly larger than the inhaler mouthpiece 10, and includes on the distal end a taut rubber ring 25 fitted over the connecting side 2.
  • the connecting side 2 is slid over the mouthpiece 10, and the rubber ring is pushed from the top of adaptor connecting side 2 over the mouthpiece of the inhaler 10.
  • the interior of the attachment side in which the attachment side of an interior cone 9 is located, and the inhaler mouthpiece, link end to end, forming a seal.
  • a conical wall 8 is formed on the inside of the transition section 4. The interior wall forms a smooth transition between the inhaler mouthpiece and the adaptor, thereby allowing the particles to move through the inhaler mouthpiece with minimum turbulence.
  • the adaptor does not act to hold-up flow of medication.
  • the mouthpiece side in the adaptor of Figure 3 could be shaped, e.g., according to the first or second embodiment.
  • a fourth embodiment of the instant invention is shown in Figure 6. As in the other embodiments, the fourth embodiment consists of a connecting side 2, a transition section 4, and a mouthpiece side 3.
  • the transition section 4 comprises an elongate, curved, generally tubular section of constantly narrowing cross-section.
  • the cross-sectional shape of the transition section 4 preferably is of airfoil shape, so as to minimize turbulence whereby to keep the aerated particles from colliding and coagulating.
  • the extension should be long enough to allow a care-giver to administer medicine from the inhaler to a person lying in a prone or semi- prone position, i.e., without the patient having to sit up or hold the inhaler.
  • the connecting means facilitates the immediate passage or medication between the inhaler mouthpiece and the oral contact means of the adaptor, without acting as a holding chamber for the medication.
  • the mouthpiece adaptor or the MDI or DPI itself includes electronic means to teach the patient to retrieve a proper breathing pattern.
  • Such electronic means includes a sensor 14, an on/off switch 15, a power source 16, actuation controller 17, noise or light generating means 18, a light 12, and optionally a speaker 13.
  • the actuation controller 17 supplies power to the noise and light generating means 18 only when the sensor 14 detects a patient is inhaling and the power switch 15 is on.
  • the noise or light generating means 18 determines the strength and frequency of the inhalations, and generates light and sound based upon these values.
  • the noise and light generating means 18 causes a light 12 to turn red, which signals to the patient to change his or her breathing pattern to conform to the protocols of the device. Correlating sounds may also be produced by the light/sound generating means 18 and output to the speaker 13.
  • the light 12 on the adaptor 1 changes from red to green, and/or the sound/light generating means 18 informs the patient that they have attained the proper breathing pattern.
  • the electronic means to teach the patient to inhale properly is integral to the inhaler.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • External Artificial Organs (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Cyclones (AREA)
  • Executing Machine-Instructions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Respiratory Apparatuses And Protective Means (AREA)
  • Prostheses (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Percussion Or Vibration Massage (AREA)
EP02761817A 2001-09-06 2002-09-06 Inhalateur type DPI Expired - Lifetime EP1446172B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CY20101100599T CY1110147T1 (el) 2001-09-06 2010-06-29 Εισπνευστικη συσκευη τυπου dpi

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31770601P 2001-09-06 2001-09-06
US317706P 2001-09-06
PCT/US2002/030308 WO2003022332A2 (fr) 2001-09-06 2002-09-06 Adaptateurs destines a des inhalateurs pour ameliorer les performances

Publications (3)

Publication Number Publication Date
EP1446172A2 true EP1446172A2 (fr) 2004-08-18
EP1446172A4 EP1446172A4 (fr) 2005-07-20
EP1446172B1 EP1446172B1 (fr) 2010-04-14

Family

ID=23234910

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02761817A Expired - Lifetime EP1446172B1 (fr) 2001-09-06 2002-09-06 Inhalateur type DPI

Country Status (18)

Country Link
US (2) US7343914B2 (fr)
EP (1) EP1446172B1 (fr)
JP (1) JP4846976B2 (fr)
KR (2) KR100998394B1 (fr)
CN (2) CN100374171C (fr)
AT (1) ATE464083T1 (fr)
AU (1) AU2002327052B2 (fr)
CA (1) CA2459867C (fr)
CY (1) CY1110147T1 (fr)
DE (1) DE60236011D1 (fr)
DK (1) DK1446172T3 (fr)
ES (1) ES2343239T3 (fr)
IL (1) IL160628A0 (fr)
MX (1) MXPA04001859A (fr)
NZ (1) NZ531614A (fr)
PL (1) PL203183B1 (fr)
PT (1) PT1446172E (fr)
WO (1) WO2003022332A2 (fr)

Cited By (2)

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GB2556016A (en) * 2016-06-20 2018-05-23 Smartair Medical Ltd Device for monitoring medication intake
US11590300B2 (en) 2016-04-12 2023-02-28 Biocorp Production S.A Metered dose inhaler add-on device, observance improvement system and method for improving observance of use in metered dose inhalers

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WO2005044173A1 (fr) * 2003-10-27 2005-05-19 Oriel Therapeutics, Inc. Emballages-coque et procedes associes de fabrication de systemes de confinement de medicaments en poudre seche
CN100589849C (zh) * 2004-02-24 2010-02-17 微计量技术有限公司 基于合成射流的药物输送方法和装置
DE102004012093A1 (de) * 2004-03-05 2005-09-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverinhalator mit Merkanaldüse
US8361026B2 (en) 2005-02-01 2013-01-29 Intelliject, Inc. Apparatus and methods for self-administration of vaccines and other medicaments
US9022980B2 (en) 2005-02-01 2015-05-05 Kaleo, Inc. Medical injector simulation device
US8206360B2 (en) 2005-02-01 2012-06-26 Intelliject, Inc. Devices, systems and methods for medicament delivery
CN101111281B (zh) * 2005-02-01 2013-02-06 因特利杰克特有限公司 用于药物递送的设备、系统和方法
US8231573B2 (en) 2005-02-01 2012-07-31 Intelliject, Inc. Medicament delivery device having an electronic circuit system
DE102005010965B3 (de) * 2005-03-10 2006-08-03 Medspray Xmems Bv Inhalator mit einem Mischkanal zum Erzeugen eines zu inhalierenden Aerosols
EP1866016A4 (fr) * 2005-03-30 2011-02-16 Canon Kk Appareil d'éjection de médicament liquide
CN101291701A (zh) * 2005-08-22 2008-10-22 麦迪斯特里姆有限公司 药物分配器及其承载器
EP2357015A3 (fr) 2006-04-05 2012-07-25 MicroDose Therapeutx, Inc. Dispositif d'inhalation à doses variables
US20080087279A1 (en) * 2006-10-11 2008-04-17 Tieck Catharine Laureen Johnso Metered dose inhaler
WO2008091838A2 (fr) * 2007-01-22 2008-07-31 Intelliject, Inc. Injecteur médical équipé d'un système de détection et de surveillance de l'observance
JP5570996B2 (ja) 2007-12-14 2014-08-13 エアロデザインズ インコーポレイテッド エアロゾル化可能な食料品の送達
EP2077132A1 (fr) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispositif distributeur, dispositif de stockage et procédé pour la distribution d'une formulation
US8021344B2 (en) * 2008-07-28 2011-09-20 Intelliject, Inc. Medicament delivery device configured to produce an audible output
USD994111S1 (en) 2008-05-12 2023-08-01 Kaleo, Inc. Medicament delivery device cover
BRPI0912918B8 (pt) * 2008-08-25 2021-06-22 Koninklijke Philips Electronics Nv aparelho de aplicação de fármaco respiratório, e método de encorajar o uso de um aparelho respiratório de liberação de drogas
DE102008054431B3 (de) 2008-12-09 2010-06-17 Pari Pharma Gmbh Aerosoltherapievorrichtung
GB2468108A (en) * 2009-02-18 2010-08-25 Jaqueline Scott Asthma inhaler kit adapted to make sound upon inhalation and exhalation
EP2414560B1 (fr) 2009-03-31 2013-10-23 Boehringer Ingelheim International GmbH Procédé de revêtement d'une surface d'un composant
JP5763053B2 (ja) 2009-05-18 2015-08-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング アダプタ、吸入器具及びアトマイザ
MY159925A (en) * 2009-05-21 2017-02-15 Microdose Therapeutx Inc Rotary cassette system for dry powder inhaler
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KR100998394B1 (ko) 2010-12-03
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CN101239212A (zh) 2008-08-13
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US20080228099A1 (en) 2008-09-18
NZ531614A (en) 2006-07-28
CY1110147T1 (el) 2015-01-14
MXPA04001859A (es) 2004-06-15
PT1446172E (pt) 2010-05-06
PL373584A1 (en) 2005-09-05
EP1446172B1 (fr) 2010-04-14
PL203183B1 (pl) 2009-09-30
CA2459867C (fr) 2012-03-13
ES2343239T3 (es) 2010-07-27
US20030041859A1 (en) 2003-03-06
AU2002327052B2 (en) 2007-10-18
DE60236011D1 (de) 2010-05-27
WO2003022332B1 (fr) 2004-07-15
ATE464083T1 (de) 2010-04-15
WO2003022332A3 (fr) 2004-06-03
CA2459867A1 (fr) 2003-03-20
WO2003022332A2 (fr) 2003-03-20
KR20040039327A (ko) 2004-05-10
JP4846976B2 (ja) 2011-12-28
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US7343914B2 (en) 2008-03-18
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