GB2556016A - Device for monitoring medication intake - Google Patents

Device for monitoring medication intake Download PDF

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Publication number
GB2556016A
GB2556016A GB1610684.1A GB201610684A GB2556016A GB 2556016 A GB2556016 A GB 2556016A GB 201610684 A GB201610684 A GB 201610684A GB 2556016 A GB2556016 A GB 2556016A
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United Kingdom
Prior art keywords
medication
metered dose
dose inhaler
chamber
inhalation
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB1610684.1A
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GB201610684D0 (en
Inventor
Harkin Jim
Duffy Brain
Henderson Barry
Mcdaid Liam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smartair Medical Ltd
Smartair Medical Ltd
Original Assignee
Smartair Medical Ltd
Smartair Medical Ltd
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Priority to GB1610684.1A priority Critical patent/GB2556016A/en
Publication of GB201610684D0 publication Critical patent/GB201610684D0/en
Publication of GB2556016A publication Critical patent/GB2556016A/en
Withdrawn legal-status Critical Current

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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/091—Measuring volume of inspired or expired gases, e.g. to determine lung capacity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
    • A61B5/113—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb occurring during breathing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4848—Monitoring or testing the effects of treatment, e.g. of medication
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient ; user input means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0013—Details of inhalators; Constructional features thereof with inhalation check valves
    • A61M15/0016—Details of inhalators; Constructional features thereof with inhalation check valves located downstream of the dispenser, i.e. traversed by the product
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/008—Electronic counters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G16H20/13—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered from dispensers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2505/00—Evaluating, monitoring or diagnosing in the context of a particular type of medical care
    • A61B2505/07—Home care
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/087—Measuring breath flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient ; user input means
    • A61B5/7475—User input or interface means, e.g. keyboard, pointing device, joystick
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/587—Lighting arrangements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A61M2205/6018—General characteristics of the apparatus with identification means providing set-up signals for the apparatus configuration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A61M2205/6045—General characteristics of the apparatus with identification means having complementary physical shapes for indexing or registration purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A61M2205/6054—Magnetic identification systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A61M2205/6063—Optical identification systems

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Physiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dentistry (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

A device 1 used in conjunction with a valved holding chamber or spacer, 2, and a metered dose inhaler (MDI) 3, capable of recording and improving the delivery of medicine into a patients airway. The device comprises a flow passage forming sealed connections with the MDI outlet and the spacer inlet. The device may further comprise a pressure sensor to detect dispending of medication from the MDI or into the spacer, or the rate and volume of air flow during use. A timer may record the start or duration of dispensation. Agitation of the device may be measured and timed. Feedback to the user may be visual or audible, may consist of LEDs 12 and may be configured to indicate device condition, medication type or dosage, inhalation rate or adherence to optimal inhalation rate. The device may comprise data processing and storage means capable of connecting to other devices.

Description

(71) Applicant(s):
Smart Air Medical Limited
C-TRIC, Altnagelvin Hospital, Glenshane Road,
DERRY, N Ireland, BT47 6SB, United Kingdom (72) Inventor(s):
Jim Harkin Brain Duffy Barry Henderson Liam McDaid (74) Agent and/or Address for Service:
FRKelly
Mount Charles, BELFAST, Northern Ireland, BT7 1NZ, United Kingdom (51) INT CL:
A61M 75/00(2006.01) G16H 20/13 (2018.01) (56) Documents Cited:
EP 3247434 A1 EP 1446172 A2
WO 2015/066562 A2 WO 2011/083377 A1 WO 2011/073806 A1 (58) Field of Search:
INT CLA61M, G06F, G16H
Other: EPODOC, WPI, Patents Fulltext (54) Title of the Invention: Device for monitoring medication intake
Abstract Title: A device connected between inhaler and spacer to monitor inhaled medication compliance and provide feedback toward optimal inhalation technique (57) A device 1 used in conjunction with a valved holding chamber or spacer, 2, and a metered dose inhaler (MDI) 3, capable of recording and improving the delivery of medicine into a patient’s airway. The device comprises a flow passage forming sealed connections with the MDI outlet and the spacer inlet. The device may further comprise a pressure sensor to detect dispending of medication from the MDI or into the spacer, or the rate and volume of air flow during use. A timer may record the start or duration of dispensation. Agitation of the device may be measured and timed. Feedback to the user may be visual or audible, may consist of LEDs 12 and may be configured to indicate device condition, medication type or dosage, inhalation rate or adherence to optimal inhalation rate. The device may comprise data processing and storage means capable of connecting to other devices.
Figure GB2556016A_D0001
Figure 1
This print incorporates corrections made under Section 117(1) of the Patents Act 1977.
Figure GB2556016A_D0002
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2/2
Figure GB2556016A_D0003
Figure 3
Figure GB2556016A_D0004
Figure 4
Title
Device for Monitoring Medication Intake
Field of Invention
The present invention relates to a device for monitoring intake of medication; specifically compliance-to optimal inhalation technique, and compliance to prescription regimen. The device provides short and long term feedback to patients and clinicians on the levels of compliance.
Background to the Invention
A widely used method for delivery of medication to treat Asthma, Chronic Obstructive Pulmonary Disease and other respiratory diseases is by Metered Dose Inhaler. This method of delivery requires a co-ordinated series of actions by the patient to ensure that the medication within the aerosol from the Metered Dose Inhaler is deposited correctly deep in the airways.
The most commonly used method of improving the efficacy of medication delivery from Metered Dose Inhalers is the use of a Valved-Holding-Chamber or Spacer device in conjunction with the Metered Dose Inhaler.
Improper use can be caused by not shaking the Metered Dose Inhaler sufficiently in order to mix medication and propellant prior to actuation, not actuating the Metered Dose Inhaler immediately after shaking, not co-ordinating the Metered Dose Inhaler actuation and inhalation, or not inhaling at an optimal rate or for sufficient duration. It is understood that prolonged poor use of a Metered Dose Inhaler leads to significant problems for patients and ongoing poorly managed conditions.
There are devices available which measure and record the breathing pattern of a patient during the use of a Metered Dose Inhaler by measuring the flow characteristics. Some provide short term feedback to the patient and some record data to be used by patients and clinicians to more closely monitor the use of the Metered Dose Inhaler and to optimise its use to achieve better outcomes. However, none of the devices currently available measure or collect all of the data which can be used during the short or long term optimisation and some have parts which may cause an obstruction to flow, and therefore may cause the medication not to reach the patient’s airways.
Statement of Invention
A medical device to be used in conjunction with a Metered Dose Inhaler and ValvedHolding-Chamber or Spacer which records and aids improvement in the delivery of medicine into the airways comprising;
flow passage with inlet and outlet sides means of connecting inlet side of said flow passage to outlet of a Metered Dose
Inhaler to from a seal means of connecting outlet side of said flow passage to inlet side of a ValvedHolding-Chamber or Spacer to form a seal
Said flow passage may be configured such that the flow of the medication is unobstructed.
Said device may be provided with means of determining duration of agitation before dispensing of medication and correct sequence of user actions thereafter.
Said Device may be provided with pressure sensor to detect dispensing of medication from Metered Dose Inhaler.
The device may be provided with means of determining which medicine is dispensed.
The device may use a pressure sensor to determine the rate and volume of flow of air during use.
The device may be provided with means of indicating real-time inhalation rate to a patient during use.
The device may be provided with means of processing and storing all data collected and 25 then communicating said data to other electronic devices for data analysis.
The device may be incorporated into a system to be used to drive improvement in patient outcomes through detailed analysis of data in the short and long term.
Brief Description of drawings
The invention will be more clearly understood by the following description of one preferred embodiment, given by way of example only, with reference to the accompanying drawings in which:Figure 1 is an isometric view of one preferred embodiment of the present invention shown between a Metered Dose Inhaler and a Valved-Holding-Chamber.
Figure 2 is an isometric view of the preferred embodiment of the present invention shown in Figure 1, after it has been installed between a Metered Dose Inhaler and a V alved-Holding-Chamber.
Figure 3 is an isometric view of the preferred embodiment of the present invention shown in Figure 1, showing the inlet side of the flow passage.
Figure 4 is an isometric view of the preferred embodiment of the present invention shown in Figure 1, showing the outlet side of the flow passage.
Detailed Description
Figure 1 shows an isometric view of one preferred embodiment of the present invention, where the device (1) is shown as an accessory located between a Valved-Holding-Chamber (2) and a Metered Dose Inhaler (3). In this embodiment the device includes an outlet interface which replaces the usual end cap of a compatible Valved-Holding-Chamber or Spacer.
The process of monitoring and recording each use of the device is initiated by depressing the start button (4), which commences a check sequence of the device, including starting a timer and logging the start event. An array of LEDs (8) indicates that the device is ready for use or for fault condition display.
Holding in the start button allows sequential illumination of a coloured LED array. User illuminates their pre-assigned LED colour which relates to the medication type and or dose they are about to take. The illuminated colour is recorded.
As the Metered Dose Inhaler is brought towards the inlet side (5) of the device, the device detects which particular medication is about to be administered before connecting to the Metered Dose Inhaler by, for example detecting the colour of the Metered Dose Inhaler through a sensor (7). The Metered Dose Inhaler is then connected to the inlet side (5) of the device. Once connected, the entire assembly is then shaken to agitate the medication and propellant contained in the Metered Dose Inhaler. This ensures medication is dispensed when the Metered Dose Inhaler is actuated and not just propellant. An accelerometer in the device is used to detect this agitation, and the duration of agitation is recorded by the timer.
The medication is then dispensed from the Metered Dose Inhaler in the normal manner by actuation of the Metered Dose Inhaler canister (9), which outputs a metered dose of medication into the Valved-Holding-Chamber. This preferred embodiment of the invention has a bi-directional through flow differential pressure sensor which has one port (10) to sense atmospheric pressure, and another port (11) to sense the internal pressure of the Valved-Holding-Chamber. This differential pressure sensor will detect the increase in pressure inside the Valved-Holding-Chamber when the medication is dispensed and the time of the event is recorded. That the dispensing of the medication occurs before the medication has had time to settle out of suspension in the Metered Dose Inhaler after agitation will form part of the compliance score achieved.
The patient then inhales the medication, now suspended in the Valved-Holding-Chamber. This causes a change in the internal pressure of the Valved-Holding-Chamber which is detected by the differential pressure sensor. This event is also recorded by the device and forms part of the compliance score achieved. To achieve optimal deposition of the medication deep in the patient’s airways the rate and duration of inhalation are critical.
The differential pressure sensor is used to determine the flow rate from the ValvedHolding-Chamber. A second array of LEDs (12) is located on the outlet side of the device facing the patient during use. These are configured to give real-time feedback to the patient as to how close to the optimum their inhalation rate is, so that they can either increase or decrease their inhalation rate. In this preferred embodiment this achieved by having a central green LED (13) illuminate when the inhalation rate is optimum. One of 2 yellow LEDs (14) on either side of the green LED illuminates when the rate is near optimum, and the patient is prompted to either increase or decrease the inhalation rate slightly dependent upon which LED is illuminated. One of 2 red LEDs (15) on either side of the yellow LEDs illuminates to indicate that the inhalation rate is far from the optimum. This immediate short term feedback to the patient encourages proper use of the device.
All of the data recorded by the device may be stored directly on the device.
The data recorded by the device may also be transferred to a computer or mobile device for analysis against predetermined ranges. This analysis compares the data from the device with predetermined ranges for each criterion and arrives at a percentage compliance score. The compliance scores may be used by the patient or a clinician over the short and long term, so that scores can be monitored to better inform clinical decisions. The score may also be used to quantify any improvement.
The type of medication used in each case can also be determined by manual input, bar coding, RFID tag, mechanical interlock or other suitable means.
The immediate feedback to the patient about the inhalation rate during use may also be provided by other visual, audio or other sensory means.

Claims (3)

1. A device to be used In conjunction with a Metered Dose Inhaler and Valvsd-HoldingChamber or Spacer which records and aids improvement in the delivery of medicine into the
5 airways comprising;
a flow passage with inlet and outlet sides;
means of connecting the inlet side of said flow passage to the outlet of a Metered Dose inhaler to from a seal;
means of connecting outlet side of said llow passage to inlet side of a Valved10 HoldingOhamber or Spacer to form a seal.
2- The device as claimed in alolm 1, further comprising a pressure sensor configured Io detect dispensing of medication from the Metered Dose inhaler1S 3. The device as claimed in claim 2, wherein the pressure sensor Is configured to detect the dispensing of he medication from the metered dose Inhaler into the Valved-holdingchamber.
4. The device as claimed in claim 2 or 3, wherein the pressure sensor comprise a bi-directional
20 through flow differential pressure sensor which has a first port configured to sense atmospheric pressure and a second port configured to sense the internal pressure of the Valved-Holdlng-Chamber
5. The devices as claimed in claim 4, wherein the differential pressure sensor Is configured to
25 detect the increase in pressure Inside the Vaived-HoUIng-Chamber when the medication is dispensed and record the time (hat this occurs.
6- The device es clcimed in daim 6, wherein the differential pressure sensor is configured to detect a change in the internal pressure or the Vah/ed-Holdlng-Chamber when a user Inhales
30 the medication from the Valved-holdlng-chamber.
7- The device as claimed in any preceding claim, further comprising means of determining agitation of the device and the duration of agitation before dispensing the medication.
3S 8. The device aa claimed in claim 7, wherein the meana of determining agitation and the duration of agitation comprises an accelerometer configured to detect the agitation and a timer configured to record the duration of the agitation.
9. The device as claimed in any preceding claim, further comprising a.start button which Is
40 configured to commence a ohaok sequence of the device including starting a timer and logging the start event when the start button Is depressed.
10, The device as claimed in claim 9, furthar comprising an array of LED's located on the inlet side of the device which are configured to Indicate that the device Is ready far use or fault condition display.
11. The device as claimed in claim 10, wherein the array of LED’s comprises a coloured LED array and wherein the LED's are configured to sequentially illuminate when the start button is depressed for a period of time.
10 12. The device as claimed in claim 11, wherein saoh of a plurality of medication types and/or dosages Is pre-assigned an LED colour In the coloured LED array.
13. The device as claimed In any preceding claim, wherein the device is provided with means of determining which medicine Is dispensed.
is
14. The device as claimed in otaim 13, wherein the meana of determining which medicine is dispensed comprises a sensor configured to detect the colour of the metered dose Inhaler.
15. The device as claimed In claim 13, wherein the means of determining which medicine is
20 dispensed comprises manual input, bar coding, RFID tag, meohanloal interlock or other suitable means.
16. The device as claimed in any preceding claim, wherein die device further comprises a pressure sensor configured to determine the rate and volume of flow of air during use.
17. The device as oiaimed in any preceding claim wherein the device Is provided with means of indicating real-time inhalation rate to a patient during use.
16. The device as oiaimed in olaim 17, wherein the means of indicating real-time inhalation rats 30 comprises visual means.
19. The device as claimed In claim 18, wherein the vleual means comprises an array of LEDs located on the cutlet aide of the device.
35 20. The device as claimed in claim 19, wherein the LEDs comprise a central green LED configured to Illuminate to indicate when the inhaialion rate is optimum.
21 · The device as claimed in claim 20, wherein the LEDs further comprise two yellow LEDs which are located on either aide of the green LED which are configured to illuminate to
40 Indicate when the Inhalation rate is near optimum.
22. The device as claimed In claim 21, one <rf the yellow LEDs is configured to Illuminate and to Indicate to a user to Increase the inhalation rats and wherein the other yellow LED Is configured to illuminate to indicate to the user to decrease the inhalation rale when the Inhalation rate is near optimum,
23. The device ae claimed in claim 22, further comprising two red LEDs which are located on either side of the two yellow LEDs and which are configured to illuminate to indicate when ths inhalation rate le far from optimum.
10 24, The device as claimed in claim 17, wherein the means of Indicating real-time Inhalation rate comprises audio or other sensory means.
25. The device as claimed in any preceding claim, wherein the device is provided with means of processing and storing data collected and then communicating said data to other electronic
16 devices tor data analysis wherein the data analysis comprises comparing the data from the device with pre-determined ranges.
28. The device as claimed in any preceding claim, wherein the flow passage la configured such • that the flow of the medication is unobstructed, * 27· A method of using a device in conjunction with a Metered Dose Inhaler and Valved-Holcfing, Chamber or Spacer for aiding Improvement In the delivery of medicine into the airways, the ' method comprising the steps of;
Connecting the motored dose inhaler and valved-holding-ohamber to the device;
26 Shaking the device to agitato tha medication and propellant contained In the metered dose inhaler;
* ( Actuating the metered dose inhaler to dispense medication Into the valvad-holding1 chamber;
Detecting Inhalation ef the medication from the valved-hafding-chamber;
30 Displaying an indication of the inhalation rate and how doss this is to the optimum.
28. A metered dose Inhaler and valved holding chamber or spacer Including the device as claimed in claim 1.
Intellectual
Property
Office presewn_
Application No: GB1610684.1 Examiner: Mr Michael Knight
GB1610684.1A 2016-06-20 2016-06-20 Device for monitoring medication intake Withdrawn GB2556016A (en)

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US20210045657A1 (en) * 2018-03-02 2021-02-18 Singapore Health Services Pte Ltd Device and method for measuring respiratory air flow
US20210146070A1 (en) * 2019-07-04 2021-05-20 NuvoAir AB Assembly and a method of operating the assembly
CN112933351A (en) * 2021-01-28 2021-06-11 赛客（厦门）医疗器械有限公司 Intelligent medicine administration management method for multi-dose micro-inhaler
WO2021223753A1 (en) * 2020-05-08 2021-11-11 Microbase Technology Corp. Method for estimating inhale dose of a person
US20220115107A1 (en) * 2019-02-14 2022-04-14 Reciprocal Labs Corporation Systems and Methods for Improving Respiratory Medicament Device Usage
GB2605170A (en) * 2021-03-24 2022-09-28 Respiratory Analytics An inhaler monitoring device
EP3952960A4 (en) * 2019-04-12 2023-01-04 National University of Singapore Inhalable medical aerosol dispensing system

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WO2011073806A1 (en) * 2009-12-16 2011-06-23 Koninklijke Philips Electronics N.V. Color identification for drug delivery system
WO2011083377A1 (en) * 2010-01-07 2011-07-14 Koninklijke Philips Electronics N.V. Respiratory drug delivery apparatus including a feedback and compliance device
WO2015066562A2 (en) * 2013-10-31 2015-05-07 Knox Medical Diagnostics Systems and methods for monitoring respiratory function
EP3247434A1 (en) * 2015-01-22 2017-11-29 Koninklijke Philips N.V. Feature assigned inhalation aid

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EP1446172A2 (en) * 2001-09-06 2004-08-18 Microdose Technologies Inc. Adaptors for inhalers to improve performance
WO2011073806A1 (en) * 2009-12-16 2011-06-23 Koninklijke Philips Electronics N.V. Color identification for drug delivery system
WO2011083377A1 (en) * 2010-01-07 2011-07-14 Koninklijke Philips Electronics N.V. Respiratory drug delivery apparatus including a feedback and compliance device
WO2015066562A2 (en) * 2013-10-31 2015-05-07 Knox Medical Diagnostics Systems and methods for monitoring respiratory function
EP3247434A1 (en) * 2015-01-22 2017-11-29 Koninklijke Philips N.V. Feature assigned inhalation aid

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210045657A1 (en) * 2018-03-02 2021-02-18 Singapore Health Services Pte Ltd Device and method for measuring respiratory air flow
US20220115107A1 (en) * 2019-02-14 2022-04-14 Reciprocal Labs Corporation Systems and Methods for Improving Respiratory Medicament Device Usage
EP3952960A4 (en) * 2019-04-12 2023-01-04 National University of Singapore Inhalable medical aerosol dispensing system
US20210146070A1 (en) * 2019-07-04 2021-05-20 NuvoAir AB Assembly and a method of operating the assembly
WO2021223753A1 (en) * 2020-05-08 2021-11-11 Microbase Technology Corp. Method for estimating inhale dose of a person
CN112933351A (en) * 2021-01-28 2021-06-11 赛客（厦门）医疗器械有限公司 Intelligent medicine administration management method for multi-dose micro-inhaler
GB2605170A (en) * 2021-03-24 2022-09-28 Respiratory Analytics An inhaler monitoring device
GB2605170B (en) * 2021-03-24 2023-09-27 Respiratory Analytics An inhaler monitoring device

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