EP1439002B1 - Dispositif de dosage - Google Patents

Dispositif de dosage Download PDF

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Publication number
EP1439002B1
EP1439002B1 EP03022019A EP03022019A EP1439002B1 EP 1439002 B1 EP1439002 B1 EP 1439002B1 EP 03022019 A EP03022019 A EP 03022019A EP 03022019 A EP03022019 A EP 03022019A EP 1439002 B1 EP1439002 B1 EP 1439002B1
Authority
EP
European Patent Office
Prior art keywords
actuating
sensor
proportioning
driving motor
proportioning device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP03022019A
Other languages
German (de)
English (en)
Other versions
EP1439002A3 (fr
EP1439002A2 (fr
Inventor
Bernd Jagdhuber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eppendorf SE
Original Assignee
Eppendorf SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eppendorf SE filed Critical Eppendorf SE
Priority to EP08008870A priority Critical patent/EP1974819B1/fr
Publication of EP1439002A2 publication Critical patent/EP1439002A2/fr
Publication of EP1439002A3 publication Critical patent/EP1439002A3/fr
Application granted granted Critical
Publication of EP1439002B1 publication Critical patent/EP1439002B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/0227—Details of motor drive means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/08—Ergonomic or safety aspects of handling devices
    • B01L2200/087—Ergonomic aspects
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips
    • B01L3/0279—Interchangeable or disposable dispensing tips co-operating with positive ejection means

Definitions

  • the invention relates to a metering device.
  • Dosing devices are used in the laboratory for dosing liquids. In general, they have a displacement device with a displacement element, by the displacement of a liquid or an air column is moved. They are known in particular in the following statements:
  • Dosing devices operating on the principle of the air cushion have a piston-cylinder unit by means of which an air column can be displaced in order to suck liquid into and out of a pipette tip.
  • the piston-cylinder unit does not come into contact with the liquid. Only the pipette tip, which is usually made of plastic, is wetted and can be replaced after use.
  • a syringe is filled with sample liquid. Piston and cylinder of the syringe are wetted by the liquid, so that the syringe is usually replaced or cleaned by a new syringe before dosing another liquid.
  • the syringe is usually made of plastic.
  • Piston-free metering devices have, for example, a pipette tip with a balloon-like end section, which expands to suck in liquid and is compressed for ejection.
  • Such pipette tips have also been designed as a replacement part.
  • Dispensers are dosing devices that can repetitively dispense a quantity of liquid in small quantities.
  • multichannel dosing devices that include multiple dosing devices to dose multiple quantities of liquid simultaneously.
  • Air-cushion, direct-displacement and piston-less metering devices may have a fixed or a variable metering volume.
  • a change in the dosing volume is usually achieved by changing the displacement of the displacement device.
  • the displacement of the piston or the degree of deformation of the balloon-like end portion changed or replaced the displacement device.
  • the operator receives a tactile feedback. Any change in the force required to operate is immediately noticed. This allows the operator to check that the dosing device is working correctly.
  • the speed of picking up and dispensing the liquid can be varied by the operator directly and without delay. Also, a discharge of the liquid in a free jet is possible. A contact between metering device and a vessel for the liquid can be avoided in this case.
  • the metering device is independent of a power supply. It can be used intuitively by the user. A complicated instruction or programming is not required.
  • the displacement device In electrical metering devices, the displacement device is driven by means of an electric drive motor. The operator must operate electrical buttons or switches to control the operations. These metering devices have the advantage that the operation requires no significant power requirement.
  • the disadvantage is that the user receives no direct feedback about the forces acting in the system, for example, a load increase due to clogging of the pipette tip or syringe. Also, a release of the liquid in the free jet is only possible to a very limited extent. When the battery or battery is empty, the work must be stopped. Changes in the rate of intake and delivery of fluid must be programmed. During the dosing process usually no changes are possible.
  • the US 5,389,341 discloses a motorized pipette with an actuator button in which the displacement of an actuator knob controls movement of a piston via an electronic control system.
  • the displacement of the actuating button is queried via an electronic displacement sensor and the query result is converted electronically via a stepper motor in the drive movement of the displacement device.
  • This electrical metering device has the disadvantages described above.
  • a power assisted pipette is known in which an actuating knob is connected via a piezoelectric sensor with a piston rod. Due to overstressing the piezo sensor can be destroyed.
  • the object of the invention is to provide an improved metering device with power-assisted actuation.
  • the metering device is a combination of a manual and an electrical metering device.
  • the force exerted by the operator on the actuator force is completely or partially supplied to the displacement device.
  • the sensor detects the force exerted by the operator and controls the drive motor so that an additional force is supplied to the displacer, which assists the operator-initiated force.
  • the metering device can be operated with a fraction of the force applied to a manual metering device.
  • the energy introduced by the operator is not lost, but added to the driving power of the motor.
  • the drive motor only supports the force for the operation of the displacement device. He must not position the displacing member of the displacement device (eg piston or balloon-like end portion).
  • the positioning can be controlled by the operator and / or by the mechanics of the metering device, eg by a conventional limitation of the actuating travel by means of a stop. As a result, a particularly inexpensive electric drive is possible. Further advantages of the metering device are:
  • the operator receives a tactile feedback. Any change in the force required for actuation will be noticed immediately.
  • the speed of absorption and delivery of the liquid can be varied directly and without delay.
  • the delivery of the liquid in a free jet is better than with a conventional manual dosing device, because the operator's power and the power of the drive motor add up.
  • the metering device can be used intuitively. A complicated instruction or programming is not required. If the electrical power supply is not available (for example when the battery or battery are empty), you can continue working. It is only a higher force required.
  • a motor and a battery or a battery can be designed smaller than a conventional dosing device, as these elements do not replace the energy of the operator, but only supplement.
  • the actuator is a manually axially displaceable actuator button.
  • the dosing device can be operated like a conventional manual or electronic pipette or dispenser.
  • the actuating device can be actuated against the force of a spring. This also corresponds to conventional pipettes or dispensers. The return movement of the actuator can then be controlled by the spring force.
  • the actuating device can be actuated until reaching a stop.
  • the exact positioning of the displacement element of the displacement device is determined. Again, this corresponds to conventional manual pipettes or dispensers.
  • a change Availability of the dosage is also accessible in a conventional manner by an adjustable stop.
  • the sensor is integrated in the actuating device. It may, for example, be a plate-shaped, pressure-sensitive sensor which is integrated in an actuating button perpendicular to the actuating direction. According to a further embodiment, the sensor is integrated in an actuating surface of the actuating device. According to In a further embodiment, the sensor is integrated in an actuating surface of the actuating device. According to another embodiment, the sensor is a Force Sensing Resistor, abbreviated FSR. An FSR sensor changes its electrical resistance in response to a force applied to an active surface. The resistance change can be measured at terminals of the sensor.
  • FSR Force Sensing Resistor
  • the controller constantly controls the drive motor whenever the sensor detects a force applied manually to the actuator.
  • the drive motor can then, for example, a basic friction of the system overcome in whole or in part, so that the operator only has to bring the additional force for the displacement of the displacement element and possibly a part of the system friction.
  • the controller controls the drive motor as a function of the force detected by the sensor. According to a further embodiment, the controller controls the drive motor in at least one stage, wherein at several stages, the height of the drive power increases with the force detected by the sensor. In one embodiment, the controller controls the drive motor in proportion to the force applied to the sensor. In one embodiment, the controller shuts off the drive motor when the sensor detects a large increase in force typical of reaching the stop.
  • the actuating device and the drive motor are connected via a coupling device with the displacement device.
  • the coupling device may be a Act gear.
  • the actuating device is connected via a rod with the displacement device. This allows a very simple construction, in particular in the case of a displacement device designed as a piston-cylinder unit.
  • the electric drive motor is coupled to the rod. This coupling is designed, for example, with a pinion that meshes with a toothing on the rack.
  • control knob is actuated until a connected to the rod stop abuts against a fixed counter-stop.
  • Embodiments relate to metering devices having a displacement device with a piston in a cylinder, on direct displacement and on air cushion metering devices.
  • the displacement device comprises a liquid receiving volume with a passage opening to the surroundings, and in the case of an air cushion metering device, the displacement device is connected to a receiving volume for liquid having a through-passage to the environment.
  • the actuating device is coupled to a device for releasing and / or ejecting a pipette tip and / or syringe.
  • the force required to release and / or eject a pipette tip and / or syringe is likewise reduced by the invention.
  • the metering device is a manual metering device.
  • the power supply has at least one rechargeable battery and / or at least one battery.
  • the metering device 1 has a cylindrical housing 2, from which - in the drawing - above an axially operable actuator button 3 protrudes.
  • the actuating knob 3 is connected via a rod 4 with a piston 5.
  • the piston 5 is guided in a cylinder 6.
  • a plate disc 7 On the rod 4 a plate disc 7 is attached. In the housing 2, an annular disc 8 is fixed. Between disc plate 7 and washer 8, a coil spring 9 is arranged.
  • a syringe or pipette tip 10 is fixed at the lower end of the housing 2. This is conical bottom with a passage 11 for liquid.
  • the cylinder 6 and the piston 5 are added to the syringe. Then, the housing 2 has a connection with the cylinder 6 and the piston 5 has a connection with the rod 4.
  • the cylinder 6 belongs to the housing 2 and the piston 5 is permanently fixed to the rod 4.
  • a pressure sensor 12 is integrated in the operating knob 3. This is associated with an actuating surface 13 of the actuating knob 3, which lies outside.
  • an electric drive motor 14 which carries on its drive shaft, a pinion 15 which meshes with a toothing 16 on the rod 4.
  • an electronic control 17 is housed, which is coupled to the pressure sensor 12 and the drive motor 14.
  • a battery 18 is also present in the housing 2 as a power supply for the pressure sensor 12, the drive motor 14 and the electronic control 17.
  • the force for actuating the actuating knob 3 is introduced via the rod 4 directly into the piston 5.
  • the presence and the height of a force is detected.
  • the controller 17 controls the drive motor 14 in response to the detected by the pressure sensor 12 actuating force.
  • the drive motor 14 drives the rod 4 with a force that increases with increasing force on the operation knob 3.

Landscapes

  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Fluid-Pressure Circuits (AREA)
  • Lubrication Of Internal Combustion Engines (AREA)

Claims (22)

  1. Dispositif de dosage comprenant
    - un dispositif d'actionnement (3) à actionnement manuel,
    - un capteur (12) affecté au dispositif d'actionnement (3) pour détecter une force exercée de manière manuelle sur le dispositif d'actionnement (3),
    - un moteur électrique d'entraînement (14),
    - une commande électrique (17) connectée au capteur (12) et au moteur électrique d'entraînement (14) pour commander le moteur d'entraînement (14) lors de la détection par le capteur (12) d'une force exercée sur le dispositif d'actionnement (3),
    - une alimentation en courant électrique (18) connectée au capteur (12), au moteur électrique d'entraînement (14) et à la commande électrique (17),
    - un dispositif de déplacement (5, 6) couplé au dispositif d'actionnement (3) et au moteur électrique d'entraînement (14) pour le dosage de liquide,
    - dans lequel le dispositif d'actionnement (3) est un bouton d'actionnement pouvant être coulissé axialement de manière manuelle qui est connecté au dispositif de déplacement (5, 6) par une tige (4) et dans lequel est intégré le capteur (12) qui est affecté à une surface d'actionnement (13) située sur l'extérieur du bouton d'actionnement.
  2. Dispositif de dosage selon la revendication 1, dans lequel la commande électrique est une commande électrique (17) pour la commande du moteur d'entraînement (14) lors de la détection par le capteur (12) d'une force exercée sur le dispositif d'actionnement (3) et pour arrêter le moteur d'entraînement (14), lorsque le capteur (12) détecte une forte augmentation de la force, qui est typique de l'atteinte d'une butée.
  3. Dispositif de dosage selon la revendication 2, dans lequel le dispositif d'actionnement (3) est un bouton d'actionnement pouvant être coulissé axialement de manière manuelle.
  4. Dispositif de dosage selon l'une des revendications 1 à 3, dans lequel le dispositif d'actionnement (3) peut être actionné contre la force d'un ressort (9).
  5. Dispositif de dosage selon l'une des revendications 1 à 4, dans lequel le dispositif d'actionnement (3) peut être actionné jusqu'à ce qu'une butée (7, 8) soit atteinte.
  6. Dispositif de dosage selon l'une des revendications 2 à 5, dans lequel le capteur (12) est intégré dans le dispositif d'actionnement (3).
  7. Dispositif de dosage selon la revendication 1 ou 6, dans lequel le capteur est intégré dans une surface d'actionnement (13) du dispositif d'actionnement (3).
  8. Dispositif de dosage selon l'une des revendications 1 à 7, dans lequel le capteur (12) est un FSR.
  9. Dispositif de dosage selon l'une des revendications 1 à 8, dans lequel la commande (17) est une commande pour la commande constante du moteur d'entraînement (14) lors de la détection d'une force par le capteur (12).
  10. Dispositif de dosage selon l'une des revendications 1 à 8, dans lequel la commande (17) est une commande pour la commande du moteur d'entraînement (14) en fonction de la force détectée par le capteur (12).
  11. Dispositif de dosage selon la revendication 10, dans lequel la commande (17) est une commande pour la commande du moteur d'entraînement (14) à au moins un niveau.
  12. Dispositif de dosage selon la revendication 10 ou 11, dans lequel la commande (17) est une commande pour la commande du moteur d'entraînement (14) de manière proportionnelle à la force détectée par le capteur (12).
  13. Dispositif de dosage selon l'une des revendications 1 à 12, dans lequel le dispositif d'actionnement (3) et le moteur d'entraînement (14) sont connectés au dispositif de déplacement (5, 6) par un dispositif de couplage (4).
  14. Dispositif de dosage selon l'une des revendications 2 à 13, dans lequel le dispositif d'actionnement (3) est connecté au dispositif de déplacement (5, 6) par une tige (4).
  15. Dispositif de dosage selon la revendication 14, dans lequel le moteur électrique d'entraînement (14) est couplé à la tige (14).
  16. Dispositif de dosage selon la revendication 14 ou 15, dans lequel le bouton d'actionnement (3) peut être actionné jusqu'à ce qu'une butée (7) connectée à la tige (4) appuie sur une butée antagoniste (8) fixe.
  17. Dispositif de dosage selon l'une des revendications 1 à 16, dans lequel le dispositif de déplacement (5, 6) est un piston qui est guidé dans un cylindre.
  18. Dispositif de dosage selon la revendication 17, dans lequel le dispositif de déplacement (5, 6) est une seringue (10) détachable.
  19. Dispositif de dosage selon la revendication 17, dans lequel le dispositif de déplacement (5, 6) est connecté par un canal à une pointe de pipette (10) détachable.
  20. Dispositif de dosage selon l'une des revendications 1 à 19, dans lequel le dispositif d'actionnement (3) est couplé à un dispositif pour détacher et/ou éjecter une pointe de pipette (10) et/ou une seringue.
  21. Dispositif de dosage selon l'une des revendications 1 à 20, qui est un dispositif de dosage manuel (1).
  22. Dispositif de dosage selon l'une des revendications 1 à 21, dans lequel l'alimentation en courant électrique (10) présente au moins un accumulateur et/ou au moins une pile.
EP03022019A 2003-01-16 2003-10-01 Dispositif de dosage Expired - Lifetime EP1439002B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP08008870A EP1974819B1 (fr) 2003-01-16 2003-10-01 Dispositif de dosage

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10301343A DE10301343B4 (de) 2003-01-16 2003-01-16 Dosiervorrichtung
DE10301343 2003-01-16

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP08008870A Division EP1974819B1 (fr) 2003-01-16 2003-10-01 Dispositif de dosage

Publications (3)

Publication Number Publication Date
EP1439002A2 EP1439002A2 (fr) 2004-07-21
EP1439002A3 EP1439002A3 (fr) 2005-06-08
EP1439002B1 true EP1439002B1 (fr) 2008-05-14

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
EP03022019A Expired - Lifetime EP1439002B1 (fr) 2003-01-16 2003-10-01 Dispositif de dosage
EP08008870A Expired - Lifetime EP1974819B1 (fr) 2003-01-16 2003-10-01 Dispositif de dosage

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP08008870A Expired - Lifetime EP1974819B1 (fr) 2003-01-16 2003-10-01 Dispositif de dosage

Country Status (3)

Country Link
US (1) US7146867B2 (fr)
EP (2) EP1439002B1 (fr)
DE (2) DE10301343B4 (fr)

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DE102004022419B4 (de) * 2004-05-06 2007-01-25 Eppendorf Ag Pipette
EP1849012A2 (fr) * 2005-01-28 2007-10-31 Parker-Hannifin Corporation Sonde d'echantillonnage, dispositif de prehension et interface de systemes de gestion d'echantillons de laboratoire
DE102005033378B4 (de) * 2005-07-16 2012-05-31 Eppendorf Ag Kolbenhubpipette
US8192698B2 (en) * 2006-01-27 2012-06-05 Parker-Hannifin Corporation Sampling probe, gripper and interface for laboratory sample management systems
JP2007254582A (ja) * 2006-03-23 2007-10-04 Mitsui Chemicals Inc 交互吸着法により製造した接着層およびこの接着層を含む複合体
WO2007126908A2 (fr) * 2006-03-31 2007-11-08 Artel, Inc. Système de distribution de liquide à air comprimé et procédé associé
US8597593B2 (en) 2006-12-07 2013-12-03 Brand Gmbh + Co Kg Bottle top dispenser for handling liquids
EP2125223B1 (fr) * 2006-12-07 2015-12-02 Brand Gmbh + Co Kg Appareil pièce rapportée pour bouteille pour la manipulation de liquides
US20090005789A1 (en) * 2007-06-26 2009-01-01 Charles Steven T Force Sensitive Foot Controller
FR2920675B1 (fr) 2007-09-10 2010-12-03 Gilson Sas Systeme de pipetage multicanaux comprenant un porte-pistons a guidage ameliore
US20120330571A1 (en) * 2011-06-27 2012-12-27 Lacourse John R System to measure forces on an insertion device
JP6286674B2 (ja) * 2012-10-22 2018-03-07 パナソニックＩｐマネジメント株式会社 フィルターデバイス
DE102016119873A1 (de) * 2016-10-18 2018-05-09 Als Automated Lab Solutions Gmbh Dosiervorrichtung und Verfahren zu deren Betrieb
DE102019108533B4 (de) * 2019-04-02 2020-11-19 Kulzer Gmbh Auspressvorrichtung für dentale Materialien und Verfahren zum Antreiben zumindest eines Austragskolbens eines Kartuschensystems mit einer Auspressvorrichtung
EP3928868A1 (fr) * 2020-06-22 2021-12-29 Eppendorf AG Pipette à utiliser avec une pointe de pipette ou une seringue comportant un piston et un cylindre

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Also Published As

Publication number Publication date
DE10301343B4 (de) 2004-12-09
EP1974819A2 (fr) 2008-10-01
EP1439002A3 (fr) 2005-06-08
EP1439002A2 (fr) 2004-07-21
EP1974819B1 (fr) 2011-08-10
US7146867B2 (en) 2006-12-12
DE50309835D1 (de) 2008-06-26
EP1974819A3 (fr) 2008-10-22
US20040149052A1 (en) 2004-08-05
DE10301343A1 (de) 2004-08-05

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