EP1177831B1 - Dispositif à actionnement manuel pour distribuer et/ou prélever des liquides - Google Patents

Dispositif à actionnement manuel pour distribuer et/ou prélever des liquides Download PDF

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Publication number
EP1177831B1
EP1177831B1 EP01117322A EP01117322A EP1177831B1 EP 1177831 B1 EP1177831 B1 EP 1177831B1 EP 01117322 A EP01117322 A EP 01117322A EP 01117322 A EP01117322 A EP 01117322A EP 1177831 B1 EP1177831 B1 EP 1177831B1
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EP
European Patent Office
Prior art keywords
control electronics
actuation
actuating element
interval
triggering
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP01117322A
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German (de)
English (en)
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EP1177831A2 (fr
EP1177831A3 (fr
Inventor
Ralf Braun
Peter Mahler
Jürgen Schraut
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Brand GmbH and Co KG
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Brand GmbH and Co KG
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Publication date
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Publication of EP1177831A3 publication Critical patent/EP1177831A3/fr
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/0234—Repeating pipettes, i.e. for dispensing multiple doses from a single charge
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/025—Displaying results or values with integrated means
    • B01L2300/027—Digital display, e.g. LCD, LED

Definitions

  • the present patent application relates to a repetitive manual operation Dispensing and / or receiving device for liquids with the features the preamble of claim 1.
  • the teaching of the invention relates generally to the handling of liquids. This may initially be the delivery of liquids by means of a corresponding dispensing device in a metered manner from a previously absorbed larger fluid volume or from another stored Liquid volume act. It can also be the controlled one Take up liquid subsets from liquid volumes. Finally, it can also be a combination of both methods, So both intake and delivery of liquid subsets. The latter can also be in a recurring cycle intake / release or up take action / movement / discharge.
  • Dispensers of the type in question are, for example, direct displacement or bubble-repeating pipettes for a pipette system or direct-displacement or air-cushioning dosing devices a dosing system.
  • Hand-operated repeating pipettes are hand-operated pipettes with a attached to it, large-volume syringe, from by pressing the actuator each dosed a small subset in a receptacle can be.
  • Typical volumes to be pipetted that is to say metered quantities, are, for example at 100 ul to 500 ul, with a typical syringe then, for example, a Filling quantity, which corresponds to 10 to 100 times the desired dosage.
  • An electric motor operated Repetierpipette has due to the electromotive Drive a particularly good operating comfort.
  • the to the control the electromotive drive existing control electronics offers the Possibility to specify not only the dosing quantity exactly, but also one Dosing interval for a plurality of successive doses to be executed to specify identical dosing.
  • This is in such, off practice known Repetierpipette (Direktverdränger) using programming buttons of the programming element the desired metering interval in a setting range from 0.1 to 1.0 sec., with adjustment steps of 0.1 sec are predetermined.
  • Another system known from practice has one as Bubble pipette executed Repetierpipette provided, to which a Dosierintervall between 0.1 sec and 10.0 sec can be entered.
  • a pipetting device with a memory function is known (DE 44 36 595 A1).
  • This The pipetting device has a programming element that has a manual position, a memory setting position and can take a memory operation position. is If the programming element is in the memory setting position, then an actuation is performed of the actuating element to one of the operator to determining storage volume can be recorded (or delivered). This predetermined by the operator storage volume is in Memory of the control electronics stored. Then becomes the programming element switched to the storage mode position, so performs a subsequent Actuation of the actuator by hand to the fact that the delivery (or recording) of a liquid amount of the previously stored value automatically he follows. The actuation of the actuating element then only serves the triggering of the delivery step or acquisition step, not the determination its duration.
  • the teaching is based on the problem, a dispensing and / or receiving device indicate for liquids of the type in question, in terms of the handling is further improved.
  • the core of the teaching is the control electronics as a self-learning system embody.
  • the control electronics requires no presetting of Process interval by the operator. The operator must rather just start with handling, simply in the form of individually triggered Process steps, and that until the operator to their this Given time, has found personal rhythm. Change the Operator then of the first type of actuation of the actuator to the second type of actuation of the actuating element, so sets the Control electronics will automatically continue the process steps with the process interval resulting from the time intervals of the previous individual process steps.
  • actuating the actuator is to be understood generally.
  • actuating the actuator in an executed as a push button actuator he should On the one hand include the normal case that pressing the button on the Actuation corresponds.
  • the function of Actuate the actuator meet. So you would then so the actuator constantly pressed during single doses and would it for release the single dose only briefly, then continue to press it let go.
  • Tripping time interval is the time interval between the beginning of an actuation of the actuating element and the beginning of the next following actuation of Actuator. This is also stated in the text as a time interval between the individual Operations of the actuator referred to.
  • Process interval is the time interval between the beginning of a process step and the beginning of the following process step.
  • Remaining interval is the time interval between the end of a process step and the beginning of the following process step.
  • the device shown in Figs. 1 and 2 is a dispenser in Shape of a repeating pipette 1. It is intended for a hand-operated Pipette system with such a Repetierpipette 1 and a replaceable mounted syringe 2, the filling amount is so large that from this syringe. 2 in a large number of individual steps, small doses out into a multitude can be dosed from receptacles.
  • Fig. 3 shows in the manner of a block diagram of the scheme of the invention Dispenser 1.
  • Fig. 3 is intended for understanding in the explanation of Fig. 1st and 2 are used.
  • the device 1 may be repeating pipettes 1 act as Malawiverdränger or as air cushion pipettes as well as dosing such as bottle dispensers or bottle titrators.
  • the dispenser 1 is the example of a Repetierpipette 1 in the form a Therapeuticverdrnatureers explained, without this being limiting.
  • the applications explained in the general part of the description apply when receiving and / or dispensing liquids.
  • An example of a stationary one Dosing is, for example, in the above-mentioned document "Compudil" shown.
  • the dispenser 1 shown initially has a housing 3 - pipette housing - And therein an adjusting device 4.
  • a Repetierpipette as a dispenser 1, implemented as a direct displacer, it is in the actuator 4 to a piston adjusting device, with a non-illustrated piston the syringe 2 for the purpose of single dosing of certain doses can be progressively advanced.
  • the adjusting device. 4 serves an electric motor drive 5, in turn, from a control electronics 6 is controlled. Basically, other motor drives are used, However, an electric motor drive 5 is particularly practical.
  • Fig. 1 can be seen on the housing 3 handle moldings 7 for secure detection the Repetierpipette 1, and an actuating element 8, one of the Repeater pipette 1 operator's hand is to press.
  • This Actuator 8 has the shape of a in the illustrated embodiment Actuating button. But you can also other actuators 8, for example a Betuschistswippschalter o. The like. Realize.
  • the actuator 8 is used to operate the control electronics 6. If it is operated, then the electromotive drive 5 by the control electronics 6 is driven briefly and causes the desired adjustment of the adjusting device. 4
  • actuating element 8 is also an embodiment of the actuating element 8 as non-mechanical, but purely electronic, preferably non-contact element.
  • the Version as a capacitive proximity switch or stray field sensor or the Version as an optoelectronic actuator 8, for example as Interruption photocell or reflection sensor in question.
  • Fig. 1 shows right in a dashed outline representation of an actuator the based on the principle of operation of an interruption photoelectric sensor. By Pressing on a cover plate 8 '' ' the light barrier is interrupted, that is the actuating signal of the actuating element.
  • Such a signal is evaluation technology to handle more convenient in the control electronics 6, because a clear switching threshold can be specified.
  • mechanical tend Switch for bouncing is also useful, however, is also an embodiment of the actuating element 8 as non-mechanical, but purely electronic, preferably non-contact element.
  • the Version as a capacitive proximity switch or stray field sensor or the Version as an optoelectronic actuator 8, for example as Int
  • a programming element 9 for the control electronics 6 On the housing 3 is also a programming element 9 for the control electronics 6. This is in the illustrated embodiment on the the actuating element 8 opposite side of the housing 3.
  • the programming element 9 for the control electronics 6 has in the illustrated embodiment on the one hand, a display surface in the form of the display 10, on the other several programming buttons 11.
  • this Programming device it is only important that this Programming device is present, as this is configured in detail, results for a person skilled in the average skill from his expertise.
  • Below the repeating pipette 1 in Fig. 1 and Fig. 2 can be seen several Receiving vessels 12, which in the illustrated embodiment in an 8 x 12 (96) Titerplatte 13 are summarized. Of course there are many different ones as well Variants.
  • the design of the control electronics 6 of the repeater pipette 1 is now made so that in the control electronics 6 by means of the programming element 9 a specific Dosage amount, which is here a fraction of the capacity of the syringe 2, is adjustable, the 8 at each actuation of the actuating element from the Syringe 2 is automatically dosed into a receptacle 12. That is characteristic for the function of a repeating pipette 1. Basically this function is also possible with different dosing quantities. The same applies to a dispenser 1 in the form of a dosing device.
  • At least one process interval adjustable for a plurality of consecutively executed process steps is.
  • it is the process interval by an interval for a plurality of successive doses.
  • a process step can also consist of several individual steps, for example from the sequence of a receiving step, a transport step and a Dispensing step. In the present embodiment, it remains in the Explanation of a dispensing dosing step.
  • the present technique is concerned with how the process interval t p is found.
  • the process interval t p is set by means of the programming element 9, for example, to a value of 0.4 sec.
  • the programming element 9 for example, to a value of 0.4 sec.
  • adjustment steps of 0.1 sec to 1.0 sec at intervals of 0.1 sec are available to adjustment steps of 0.1 sec to 1.0 sec at intervals of 0.1 sec.
  • Alternatives have already been explained in the general part of the description.
  • the illustrated device 1 is characterized by the fact that the process interval t p is determined by the control electronics 6 itself by evaluating the time interval occurring in the previous single or multiple individual triggers of a process step or the time intervals between the individual actuations of the actuating element 8.
  • the control electronics 6 is so here self-learning in this sense. From the triggering intervals of previous operations, the control electronics 6 determines the rhythm in which the operator doses concretely. This then specifies the process interval t p . The operator himself therefore does not have to set a process interval t p at the programming element 9, the process interval t p follows rather automatically the operating rhythm of the operator.
  • a first way to determine the process interval t p is now that of the control electronics 6, the triggering interval of the last single dose before the onset of sustained actuation of the actuating element 8 is taken as the process interval t p .
  • Fig. 4 is a flow chart is shown, which represents a further preferred embodiment of the device 1 according to the invention.
  • an average of the last n (n> 1), here the last two triggering time intervals before the onset of sustained actuation of the actuating element 8 is taken as the process interval t p .
  • n can simply include all previously expired single dosages.
  • the flowchart in FIG. 4 shows single dosages 1, 2, 3, 4, 5, wherein the automatic metering starts with step 6 and then continues via steps 7, 8, 9.
  • the last two triggering time intervals, here t p3 and t p4, are recorded before the start of the continuous actuation of the actuating element 8 in the dosing step 5. This is shown by the dashed line.
  • a weighting of the time intervals of the last n single doses may also take place during averaging. This can be done, for example, in such a way that overall the last three individual doses are detected, but in the averaging but the time interval between the last and the penultimate single dosing is doubly weighted.
  • Fig. 4 might suggest that here only the residual interval is meant. This is of course not the case, the graphic representation is the process interval t p , so describe the time interval between the beginning of a process step and the beginning of the following process step.
  • One way of evaluating the individual dosages by means of the control electronics 6 also consists in that of the control electronics 6, an average of a Plural of single doses before the automatic dosing starts a statistical evaluation is determined.
  • Such a statistical Evaluation method can also be spaced apart groups of single dosages during a longer learning phase.
  • a possibility of Realization of a statistical evaluation is for example a filter in the Control electronics 6, the atypically large and / or atypical small time intervals eliminated.
  • the control electronics 6 of the dispensing device 1 can be further designed so that a vorffentes or acquired by sustained actuation of the actuator 8 process interval t p stored in the control electronics 6 to a possible active deletion and / or until the dispenser 1 is switched off and at again continuous actuation of the actuating element 8 is effective again.
  • the once determined process interval t p is maintained even when interrupting the dosing, so that the operator can maintain the once found rhythm on.
  • An active deletion of the stored process interval t p should also be done by pressing a programming button 11 of the programming element 9 and / or by repeated multiple dosing.
  • the control electronics 6 is signaled by the operator that the operator wants a new determination of the process interval t p . Possibly, the operator has indeed changed, the new operator would like to find their own rhythm and know in the process interval t p considered. This is the embodiment of the control electronics. 6
  • the correction of the process interval tp in the previously explained sense can be done, for example, by means of a preferably permanently set correction factor.
  • the choice of the correction factor and the accuracy of the determination of the process interval t p in total is, of course, generally determined by the setting accuracy for the process interval t p . If in any case only setting steps of 0.1 sec are possible, then one can work here with a larger error than if one has a smaller pitch for the setting steps of the process interval t p in the control electronics.
  • a change of the operating rhythm of the operator after the start of the continued operation of the actuator 8 can also be taken into account that the control electronics also detects with continued actuation of the actuating element 8, the timing of the movement of the dispenser 1 and to correct the process interval t p attracts. Since in this case the operation of the actuator 8 itself can no longer be used as a control variable for the control electronics 6, one must grasp the movement of the dispenser 1 by the operator of receptacle 12 to receptacle 12 otherwise. This can be done for example via an acceleration sensor, which detects the sideways movement of the dispenser 1 by evaluating the lateral acceleration, and whose signal is evaluated by the control electronics 6 accordingly.
  • the actuator 8 as non-mechanical, especially pure electronic, and preferably perform non-contact element.
  • an optoelectronic actuator 8 as in the Section shown in Fig. 1 with light emitter 8 'and light receiver 8 "on one covered by a deformable or movable cover 8 "' Transmission path is evaluation technology, especially in terms of Evaluation software, especially useful. On the above Designs may be pointed out.
  • control electronics 6 a user-friendly system, with which also extensive Working with a hand-operated device 1 comfortable and individually pleasant and thus can be executed extremely fast.

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  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Loading And Unloading Of Fuel Tanks Or Ships (AREA)
  • Control Of Non-Electrical Variables (AREA)
  • Position Input By Displaying (AREA)

Claims (10)

  1. Dispositif de distribution et/ou de prélèvement (1) de liquides, à actionner manuellement de façon répétitive, avec un dispositif de réglage (4), un entraínement motorisé (5) pour le dispositif de réglage (4) et un système électronique de commande (6) pour l'entraínement (5), avec un élément d'actionnement (8) manuel pour le système électronique de commande (6) et avec un élément de programmation (9) pour le système électronique de commande (6), au moins une quantité de liquide qui par manipulation de l'élément d'actionnement (8) est transportable par moteur étant réglable au sein du système électronique de commande (6), à l'aide de l'élément de programmation (9), au moins un intervalle de processus (tp) pour une pluralité d'étapes du processus devant être réalisées consécutivement étant réglable au sein du système électronique de commande (6) et un premier type de manipulation de l'élément d'actionnement (8) déclenchant une étape individuelle du processus et un second type de manipulation de l'élément d'actionnement (8) produisant automatiquement un déclenchement multiple et consécutif d'étapes du processus, respectivement dans l'intervalle de processus (tp), caractérisé en ce que l'intervalle de processus (tp) est déterminé par le système électronique de commande (6) proprement dit, par évaluation de l'intervalle de temps apparaissant lors du déclenchement précédent individuel ou multiple d'une étape du processus ou des intervalles de temps entre les manipulations individuelles de l'élément d'actionnement.
  2. Dispositif selon la revendication 1, caractérisé en ce que le dispositif (1) est une pipette répétitive (à déplacement direct ou à déplacement par coussin d'air) pour un système de pipetage avec une pipette répétitive et une seringue (2) montée sur cette dernière de façon interchangeable ou en ce que le dispositif (1) est un instrument de dosage (à déplacement direct ou à déplacement par coussin d'air) pour un système de dosage avec un instrument de dosage et un récipient de réserve pour le liquide à doser.
  3. Dispositif selon l'une quelconque des revendications 1 ou 2, caractérisé en ce que le système électronique de commande (6) prend en compte en tant qu'intervalle du processus (tp) l'intervalle de temps du dernier déclenchement individuel avant le début du déclenchement automatique ou en ce que le système électronique de commande (6) prend en compte en temps qu'intervalle du processus (tp) une valeur moyenne des derniers n (n > 1), de préférence des deux derniers intervalles de temps des déclenchements individuels avant le début du second type de manipulation de l'élément d'actionnement (8), une pondération des intervalles de temps entre les derniers n déclenchements individuels étant réalisée de préférence lors du calcul de la valeur moyenne, ou en ce que le système électronique de commande (6) détermine la valeur moyenne d'une pluralité de déclenchements individuels avant le début du déclenchement automatique selon un procédé d'évaluation statistique, le système électronique de commande (6) étant muni de préférence d'un filtre pour l'exclusion d'intervalles de temps qui sont atypiquement grands et/ou petits.
  4. Dispositif selon l'une quelconque des revendications 1 à 3, caractérisé en ce qu'un intervalle de processus (tp) préalablement déterminé ou pris en compte par manipulation de l'élément d'actionnement (8) reste sauvegardé dans le système électronique de commande (6), jusqu'à une éventuelle suppression active et/ou jusqu'à la mise hors service du dispositif (1) et redevient actif lors d'une nouvelle manipulation de l'élément d'actionnement (8).
  5. Dispositif selon l'une quelconque des revendications 1 à 4, caractérisé en ce qu'une suppression active d'un intervalle de processus (tp) sauvegardé a lieu par manipulation de l'élément de programmation (9) et/ou par déclenchement individuel multiple renouvelé.
  6. Dispositif selon l'une quelconque des revendications 1 à 5, caractérisé en ce que l'intervalle de processus (tp) effectivement utilisé est dimensionné par le système électronique de commande (6) de façon un peu plus courte que l'intervalle de processus (tp) déterminé par le système électronique de commande (6) à partir des déclenchements individuels précédents, la correction étant effectuée de préférence à l'aide d'un coefficient de correction réglé de préférence à une valeur fixe ou avec une autre constante.
  7. Dispositif selon l'une quelconque des revendications 1 à 6, caractérisé en ce que également lors du second type d'actionnement, le système électronique de commande enregistre la cadence de déplacement du dispositif (1) entre les processus de déclenchement et qu'il l'implique pour la correction de l'intervalle de processus (tp), le système électronique de commande (6) étant muni de préférence d'un capteur, de préférence d'un capteur d'accélération pour déterminer le déplacement du dispositif (1) entre les processus de déclenchement.
  8. Dispositif selon l'une quelconque des revendications 1 à 7, caractérisé en ce que le premier type de manipulation de l'élément d'actionnement (8) est une manipulation courte et en ce que le second type de manipulation est une manipulation durable et/ou en ce que la manipulation du système d'actionnement (8) est une pression sur une touche d'actionnement et/ou en ce que la manipulation de l'élément d'actionnement (8) est un relâchement d'une touche d'actionnement précédemment pressée et/ou en ce que l'élément d'actionnement (8) est un élément double, avec un premier élément pour un déclenchement individuel et un second élément pour un déclenchement automatique.
  9. Dispositif selon l'une quelconque des revendications 1 à 7, caractérisé en ce que l'élément d'actionnement (8) fonctionne à la façon d'une souris d'ordinateur, avec un clic pour un actionnemen individuel et un double clic pour un actionnement durable.
  10. Dispositif selon l'une quelconque des revendications 1 à 7, caractérisé en ce que l'élément d'actionnement (8) est conçu sous forme d'un élément non mécanique, purement électronique, fonctionnant de préférence sans contact, l'élément d'actionnement (8) étant de préférence conçu en version optoélectronique, notamment sous forme de configuration de barrières photoélectriques ou de configuration de réflexion lumineuse.
EP01117322A 2000-08-03 2001-07-18 Dispositif à actionnement manuel pour distribuer et/ou prélever des liquides Expired - Lifetime EP1177831B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10038569A DE10038569C2 (de) 2000-08-03 2000-08-03 Repetierend manuell zu betätigende Abgabe- und/oder Aufnahmeeinrichtung für Flüssigkeiten
DE10038569 2000-08-03

Publications (3)

Publication Number Publication Date
EP1177831A2 EP1177831A2 (fr) 2002-02-06
EP1177831A3 EP1177831A3 (fr) 2003-06-25
EP1177831B1 true EP1177831B1 (fr) 2004-10-06

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US (1) US6841129B2 (fr)
EP (1) EP1177831B1 (fr)
JP (1) JP2002126492A (fr)
AT (1) ATE278470T1 (fr)
DE (2) DE10038569C2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10257414B4 (de) * 2002-12-05 2005-07-21 Eppendorf Ag Handdispenser mit elektromotorischem Antrieb
DE10307030A1 (de) * 2003-02-20 2004-09-09 Eppendorf Ag Dosiersystem
US7976793B2 (en) * 2003-11-27 2011-07-12 Gilson S.A.S. Electronic pipette
US7540205B2 (en) * 2007-09-17 2009-06-02 Viaflo Corp. Electronic pipettor
US8033188B2 (en) 2007-09-17 2011-10-11 Integra Biosciences Corp. Pipettor software interface
EP2231477B1 (fr) * 2007-11-08 2020-01-08 AEA S.r.l. Ensemble pour actionner une seringue
JP4883031B2 (ja) 2008-03-18 2012-02-22 パナソニック株式会社 受信装置と、これを用いた電子機器
DE102008048620B4 (de) * 2008-09-23 2011-09-15 Ahn Biotechnologie Gmbh Elektronische Kolbenhubpipette
US8632738B2 (en) * 2010-08-30 2014-01-21 Health Robotics S.r.l Syringe actuating method and assembly
DE102010047126A1 (de) * 2010-10-04 2012-04-05 Eppendorf Ag Pipette
US8871157B2 (en) * 2011-05-17 2014-10-28 Rainin Instrument, Llc Electronic pipette with two-axis controller
DE102011117963A1 (de) * 2011-11-07 2013-05-08 Eppendorf Ag Fluidtransfervorrichtung
US9839252B2 (en) 2012-05-31 2017-12-12 Bauer Hockey, Llc Visor system for a protective sport helmet
FR3063431B1 (fr) * 2017-03-06 2021-11-19 Dev Techniques Plastiques Holding Pousse seringue ergonomique
USD926224S1 (en) 2018-10-11 2021-07-27 Brand Gmbh + Co Kg Laboratory device display screen with graphical user interface

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3622279A (en) * 1968-06-14 1971-11-23 Hycel Inc Automatic chemical testing apparatus
US3887110A (en) * 1970-09-10 1975-06-03 Upjohn Co Dispensing methods and apparatus
US3951605A (en) * 1974-08-08 1976-04-20 Rohe Scientific Corporation Instrument for automated immunochemical analysis
GB1562686A (en) * 1975-10-15 1980-03-12 St Thomas Hosp Med School Apparatus for taking blood samples from a living patient
GB1561061A (en) * 1976-03-17 1980-02-13 Hycel Inc Reaction conveyor assembly in an automatic chemical testing apparatus
US4199013A (en) * 1977-04-01 1980-04-22 Packard Instrument Company, Inc. Liquid sample aspirating and/or dispensing system
US4671123A (en) * 1984-02-16 1987-06-09 Rainin Instrument Co., Inc. Methods and apparatus for pipetting and/or titrating liquids using a hand held self-contained automated pipette
US4779467A (en) * 1987-01-28 1988-10-25 Rainin Instrument Co., Inc. Liquid-end assembly for multichannel air-displacement pipette
US5576503A (en) * 1990-02-02 1996-11-19 Isco, Inc. Pumping system
US6203759B1 (en) * 1996-05-31 2001-03-20 Packard Instrument Company Microvolume liquid handling system
US5509318A (en) * 1993-10-13 1996-04-23 Manostat Corporation Memory Mopet
DE4436505A1 (de) * 1994-10-13 1996-04-18 Zahnradfabrik Friedrichshafen Automatgetriebe, insbesondere für Kraftfahrzeuge
DE19513023C2 (de) * 1995-04-06 1997-06-12 Hirschmann Glasgeraete Dosiergerät
AUPP058197A0 (en) * 1997-11-27 1997-12-18 A.I. Scientific Pty Ltd Pathology sample tube distributor
US6254832B1 (en) * 1999-03-05 2001-07-03 Rainin Instrument Co., Inc. Battery powered microprocessor controlled hand portable electronic pipette
WO2000051738A1 (fr) 1999-03-05 2000-09-08 Rainin Instrument Co., Inc. Pipette electronique portable amelioree commandee par un microprocesseur alimente par une batterie
US6299841B1 (en) * 1999-03-05 2001-10-09 Rainin Instrument Co., Inc. Bilaterally symmetrical battery powered microprocessor controlled lightweight hand-holdable electronic pipette

Also Published As

Publication number Publication date
DE10038569C2 (de) 2002-07-04
EP1177831A2 (fr) 2002-02-06
US20020018734A1 (en) 2002-02-14
ATE278470T1 (de) 2004-10-15
DE50103955D1 (de) 2004-11-11
US6841129B2 (en) 2005-01-11
JP2002126492A (ja) 2002-05-08
DE10038569A1 (de) 2002-02-21
EP1177831A3 (fr) 2003-06-25

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