EP1426122A1 - Isolator - Google Patents

Isolator Download PDF

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Publication number
EP1426122A1
EP1426122A1 EP03257430A EP03257430A EP1426122A1 EP 1426122 A1 EP1426122 A1 EP 1426122A1 EP 03257430 A EP03257430 A EP 03257430A EP 03257430 A EP03257430 A EP 03257430A EP 1426122 A1 EP1426122 A1 EP 1426122A1
Authority
EP
European Patent Office
Prior art keywords
processing zone
isolator
module
modules
modular isolator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03257430A
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English (en)
French (fr)
Inventor
Neal Horobin
Mohammed Irfan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tetra Pak CPS Ltd
Original Assignee
Extract Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Extract Technology Ltd filed Critical Extract Technology Ltd
Publication of EP1426122A1 publication Critical patent/EP1426122A1/de
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B15/00—Preventing escape of dirt or fumes from the area where they are produced; Collecting or removing dirt or fumes from that area
    • B08B15/02—Preventing escape of dirt or fumes from the area where they are produced; Collecting or removing dirt or fumes from that area using chambers or hoods covering the area
    • B08B15/023—Fume cabinets or cupboards, e.g. for laboratories

Definitions

  • the present invention relates to a modular isolator comprising a plurality of conjoined modules, each module enclosing a quadrantal processing zone, and to the module per se.
  • Effective containment is essential for the safe and hygienic handling of a pharmaceutical, chemical or biological product.
  • handling must be controlled and managed to provide optimum protection for the operator and to maintain the integrity of the product.
  • GMP Good Manufacturing Practices
  • a downflow containment assembly may comprise an operator booth of sufficient size to admit the operator for the purposes of (for example) manipulating powder handling equipment (eg large powder kegs or bins weighing devices).
  • manipulating powder handling equipment eg large powder kegs or bins weighing devices.
  • An alternative conventional containment assembly is a barrier isolator with gloved access to the processing zone in which a product and/or handling equipment may be manipulated.
  • the use of a barrier system offers improvements in the handling of pharmaceutical products in circumstances where product protection and the maintenance of asepsis, and/or operator protection and the control of hazardous substances are critical requirements.
  • a barrier isolator offers two fold protection, namely the use of glove ports to maintain a physical barrier between the product and the operator and a fan system to create air flow for removing airborne particles from the processing zone and into filters. In this manner, a barrier isolator may achieve high containment typically down to less than 10 ⁇ g/m 3 of contamination in the surrounding environment.
  • One such isolator is disclosed in EP-A-1264668.
  • Isolators have several advantages over conventional clean rooms and laminar flow cabinets for aseptic preparation and dispensation of injectable formulations. Firstly they may be sited in an unclassified environment and still provide an acceptable level of sterility for aseptic operations. Secondly costs can be minimized because a minimum amount of costly protective clothing is needed.
  • Isolators cannot however be regarded as totally sealed units since there must be open access to the processing zone when materials are transferred in and out and the processing zone is continuously supplied with HEPA filtered air. Otherwise the processing zone of the isolator is sealed from its background environment in use.
  • isolators for aseptic processing use laminar (unidirectional) airflow, turbulent airflow or a combination of the two within the processing zone for the removal of airborne particles from the processing zone and into filters. It is generally accepted that the critical zone of the controlled surface should be equivalent to the EC grade A but the airflow in the critical zone need not be laminar flow. In the situation where a laminar flow system within the controlled critical zone is not provided, it is standard industry recommended practice for tests to be performed so as to confirm that only air complying with the requirement of EC Grade A is supplied to the critical zone. Furthermore, it is required that air should be effectively swept from the processing zone and standing vortices and stagnant areas should not exist.
  • Isolator technology is now widely used for the aseptic industrial processing of pharmaceuticals. Although the revenue and capital savings that hospitals have achieved may not be realized in industry, isolator technology can improve operator and product protection and increase sterility assurance. Production lines with integrated isolation technology are now being introduced into the pharmaceutical industry. Isolators are also used in microbiology departments for sterility testing which relies heavily on an effective aseptic technique.
  • the present invention seeks to address certain disadvantages of a conventional containment assembly by providing an isolator whose modularity offers numerous permutations of overall size and shape whilst beneficially assisting the operator to work at maximum efficiency.
  • the present invention relates to a modular isolator comprising ergonomically designed modules which may be conjoined in various configurations to provide versatile and effective containment.
  • the present invention provides a modular isolator comprising a plurality of conjoined modules, each module comprises a rigid body enclosing a processing zone and being adapted or adaptable to permit an operator outside the processing zone to reach into the processing zone, wherein the processing zone is substantially quadrantal in the horizontal plane.
  • the rigid body may comprise a front face adapted or adaptable to permit an operator outside the processing zone to reach into the processing zone and opposing, substantially perpendicular side faces convergent into a connecting rear face (or a common rear edge).
  • the quadrantal configuration of the processing zone is such that the side faces of the isolator are not perpendicular to the front face thereby advantageously optimising the ergonomic performance of the module (eg improving access to the side faces and to internal components or for rendering cleaning more straightforward and effective).
  • the rigid body may be manufactured to meet the requirements of the internal components that it houses. Typically the rigid body will be constructed from stainless steel and appropriate chambers provided for the internal components which it houses. Examples of internal components may include one or more filters or fan unit(s). For example, one or more fan units and valves may be housed in a rear chamber of the rigid body.
  • an appropriate number of modules may be advantageously arranged to be used in isolation, against a flat wall of any length, in an interior or exterior comer, around a pillar (or similar elongate structure), against a stepped wall or wrapped around the walls of a room (eg wrapped around the three exterior walls of a square room).
  • the modules may be abutted directly against the walls or indirectly via a single connecting module or more than one linearly conjoined connecting module.
  • the modules may be conjoined directly or indirectly (eg spaced part by a single connecting module or more than one linearly conjoined connecting module).
  • the modular isolator comprises twin modules.
  • twin modules are conjoined directly and may be used in isolation or abutted (for example) directly against a flat wall.
  • twin modules are conjoined directly and may be abutted (for example) indirectly against a flat wall via a single connecting module to create an island extending away from the wall (or more than one linearly conjoined connecting module where it is desired to extend the island further away from the wall).
  • twin modules are conjoined indirectly by a single connecting module (or more than one (eg two) linearly conjoined connecting modules) and may be used in isolation or abutted (for example) directly against a flat wall.
  • the modular isolator comprises three modules.
  • the three modules are conjoined directly and may be used in isolation, wrapped around an elongate structure (such as a pillar) or abutted (for example) directly against an exterior corner wall.
  • modules and connecting modules may be constructed in accordance with the invention to abut against (for example) stepped walls or the interior or exterior walls of a room.
  • a plurality of conjoined modules may be advantageously exploited in a stepwise process whereby each module facilitates a single step of the process.
  • the (or each) connecting module will be generally of a similar size to that of the modules of the invention to which it is connected.
  • the (or each) connecting module is typically a conventional module which comprises a rigid body enclosing a processing zone and which may be adapted or adaptable to permit an operator outside the processing zone to reach into the processing zone, wherein the processing zone is substantially quadrangular ( eg square) in the horizontal plane.
  • the preferred features of the (or each) connecting module are as defined herein for the module of the invention and may be chosen according to the requirements of the operator. Suitable connection means (such as rapid transfer ports) known to those skilled in the art may be deployed to connect the connecting module to a module in a contained manner.
  • the processing zone may be conveniently divided into a series of chambers which are tailored in terms of size, shape and position to meet the requirements of the use to which each module of the modular isolator is to be put.
  • an operating chamber is provided at or near to the height of the torso of an operator of average height (preferably in the seated position) and towards the front of the processing zone.
  • the operating chamber may be bound by an internal rear wall (to the rear of which is a rear chamber).
  • the sides of the operating chamber may be bound by side walls (which are preferably parallel).
  • At least an upper portion of the front face of each module is multi-faceted ( ie provided with a plurality of exterior faces).
  • at least one exterior face is adapted or adaptable to permit an operator outside the processing zone to reach into the processing zone.
  • Particularly preferably at least two exterior faces are adapted or adaptable to permit an operator outside the processing zone to reach into the processing zone.
  • each module is bi-faceted ( ie provided with two exterior faces).
  • this provides the upper portion of the front face of each module essentially with a quarter of an octagonal profile and this angular disposition has been found to offer ergonomic advantages (in particular in optimising the operators reach).
  • the (or each) exterior face is inclined. This may serve to optimise ergonomic comfort of the operator and/or to assist airflow characteristics.
  • the internal rear wall bounding the operating chamber is inclined so as to be substantially parallel to the (or each) exterior face.
  • the (or each) exterior face is fully or partially transparent to provide visibility to the processing zone ( eg to the operating chamber).
  • the exterior face adaptable to permit an operator outside the processing zone to reach into the processing zone is a barrier means.
  • the barrier means may be detachable ( eg removable or openable) by suitable means to provide unhindered access to the processing zone if desired.
  • the barrier means may be hinged at one or more locations.
  • the barrier means may be sealed against the rigid body using conventional sealing methods to provide product and operator protection and maintain aseptic conditions.
  • the (or each) seal may be fitted to the barrier means or rigid body in such a way as to provide maximum sealing of the barrier to the isolator in all conditions.
  • the seal may be housed in the barrier means and act against a suitable sealing platform ( eg on the rigid body).
  • the seal may be fitted to the barrier means by (for example) a groove running along the external circumference of the barrier means and may be pneumatically or hydraulically controlled using a suitable mechanism to provide optimum sealing force and pressure against one or more rigid support structures on the rigid body.
  • Pipe work or supporting connections to the seal can be channelled to enhance the aesthetics of the modular isolator (eg a pneumatic seal hose could be channelled through the hinge mechanism(s)).
  • the (or each) exterior face comprises one or more apertures (eg substantially oval apertures) each fitted with a flexible portion in the shape of a glove (or capable of being deformed into the shaped of a glove) which permits an operator outside the processing zone to reach into the processing zone (whilst providing physical protection from the processing zone and any biological, chemical or other substances that may be present).
  • the (or each) exterior face comprises two flexible portions in the shape of a glove (or capable of being deformed into the shape of a glove) sealed conventionally for operator protection during (for example) cleaning.
  • the (or each) flexible portion in the shape of a glove comprises a flexible sleeve terminating in a gloved end (eg a gauntlet).
  • a gloved end eg a gauntlet
  • the flexible sleeve extends from the exterior face ( eg the barrier means) to beyond the operators elbow (to optimise manoeuvrability).
  • the flexible sleeve may be composed of natural or synthetic rubber or polyurethane.
  • the gloved end is typically (but not necessarily) composed of less flexible material than the flexible sleeve.
  • the gloved end may be composed of thicker polyurethane than that of the flexible sleeve (or alternatively of thicker PVC, rubber or other material).
  • the gloved end may be integral with the flexible sleeve or attached to the flexible sleeve in any conventional manner.
  • the joint between the gloved end and the flexible sleeve comprises an internal strengthening ring to which the ends of the gloved end and the flexible sleeve are attached and/or secured.
  • the ends of the gloved end and the flexible sleeve may be secured to the internal strengthening ring by an elastic band or the like.
  • the end of the (or each) flexible portion in the shape of a glove may comprise a bead or rolled edge for fitting to the exterior face ( eg the barrier means).
  • the bead or rolled edge may be stretchably mounted on to a face ring ( eg a groove of the face ring) on the exterior face ( eg barrier means) to produce an airtight joint.
  • the joint may be strengthened by a strengthening ring ( eg an o-ring) inserted into a second groove on the face ring.
  • Suitable glove sealing arrangements are disclosed in EP-A-1265257.
  • the position and orientation of the (or each) flexible portion in the shape of a glove may be tailored to suit the particular operation to be conducted in the processing zone.
  • the (or each) flexible portion in the shape of a glove may be right hand or left hand oriented as desired.
  • the rigid body further comprises: one or more transfer ports to permit contained transfer from the processing zone to a remote location.
  • the (or each) transfer port is a tubular transfer port.
  • the remote location may be a module of the invention, a connecting module, a powder bin, containment assembly, etc.
  • a first transfer port may be incorporated into a first side face.
  • a second transfer port may be incorporated into a second side face.
  • the quadrantal configuration of the processing zone is such that any transfer port in the side face of the isolator is not perpendicular to the front face adapted or adaptable to permit an operator outside the processing zone to reach into the processing zone thereby optimising the ergonomic performance of the module ( eg optimising operator access to the transfer port).
  • the processing zone may be provided with a work platform (preferably a perforated work platform).
  • a work platform is typically in the operating chamber and may be equipped with means for determining its horizontal level ( eg by using a spirit level type device) and may be adjustable by (for example) adjustable screw fixings, pneumatic or hydraulic levelling mechanisms.
  • the work platform is located at or near to the waist height of a typical operator. Beneath the working platform is a lower chamber.
  • the modular isolator may be adapted to provide non-circulatory airflow in the processing zone.
  • air exhausted from the processing zone may be ducted to atmosphere or to a remote location (eg a fan/filter stack).
  • the modular isolator further comprises:
  • the first chamber is the lower chamber and the second chamber is the upper chamber.
  • the or each outlet may be incorporated in (but not necessarily parallel to) a lower wall bounding the lower chamber (beneath the working platform) and the or each inlet may be incorporated above (but not necessarily perpendicular to) the working platform.
  • the or each outlet is generally fitted with an outlet filter and the or each inlet is generally fitted with an inlet filter.
  • a filter may be fitted to the rigid body using conventional mechanical and/or adhesive means (eg using silicone gel and knife-edge sealing technology in a suitable configuration).
  • the filter is a conventional HEPA filter.
  • the modular isolator of the invention is adapted so that air flows downwardly in an undisturbed, non-turbulent manner in the processing zone at a pre-determined velocity.
  • the rigid body is adapted to attain laminar flow (eg perfect laminar flow (PLF) of air in the processing zone).
  • the inlet is preferably fitted with PLF material (eg a PLF screen) through which the air flows to the processing zone.
  • PLF material eg a PLF screen
  • the inlet may be fitted with a tensioned monofilament woven screen providing uniform air flow over its entire area.
  • the screen may be fitted to the inlet in a conventional manner ( eg using standard adhesives such as urethane adhesives).
  • the PLF screen may be a perimeter frame ( eg of welded steel) which is typically cross braced ( eg with hollow tubes) to resist the tensile forces of a monofilament textile screen stretched and fixed to the perimeter of the frame.
  • the monofilament textile screen retards the passage of air so that it is forced to pass through it with an even velocity distribution (the down flow velocity) which suppresses the rise of particles in the processing zone.
  • the down flow velocity the velocity distribution which suppresses the rise of particles in the processing zone.
  • the inlet filter itself provides laminar flow air to the processing zone.
  • the inlet filter eg HEPA inlet filter
  • the inlet filter may be a construction with appropriate rigidity and structure and a suitable shape to provide a similar function to a PLF screen.
  • the inlet filter retards the passage of air so that it is forced to pass through it with an even velocity distribution (the down flow velocity) which suppresses the rise of particles in the processing zone.
  • the upper chamber defines a plenum capable of transmitting the airflow downwardly into the processing zone.
  • the upper chamber is adapted to contribute to laminar flow (eg PLF).
  • the upper chamber may take the form of a profiled canopy capable of providing a smooth and uninterrupted airflow into the inlet fitted with a PLF screen and/or the inlet filter ( eg a HEPA filter).
  • the means for inducing airflow may comprise any conventional fan unit eg a fan unit driven by a flange mounted inverter controlled motor which ensures smooth drive via a flexible coupling.
  • the means for inducing air flow may be located in the rear chamber.
  • the fan unit may be placed downstream from a filter ensuring that it only receives clean filtered air.
  • the fan unit may be a double scroll double inlet type fan optionally but preferably with automatic constant volume control which compensates for filter congestion and with set back duty for when the modular isolator is operated in isolator mode.
  • the fan unit may be seated on highly compressed antivibration mounts to ensure that no vibration is passed onto adjacent parts of the body.
  • the fan may be programmable to switch between any number of different volumetric flow rates for use in various operational modes and process requirements.
  • the rigid body may comprise a bleed port (eg suitably dusted from the airflow circuit) which is open for use in standard isolator mode but which may be closed (if desired) to allow the discharge of air for the effective operation of the modular isolator.
  • the bleed port may (if desired) be substituted by a filter (eg a HEPA filter) to further minimize the risk of environmental contamination.
  • the modular isolator may further comprise one or more vents to ensure that the temperature of the air in the motor section does not rise to unacceptable levels though the action of the motor on the fan (if the fan is not self cooling).
  • the venting of the motor chamber may be aided by an additional cooling or air-circulating fan.
  • the modular isolator is adapted to accommodate negative and positive pressure (eg by operating valves for inlet and outlet airflow in relation to filter position in the airflow circuit).
  • Laminar flow light fittings or luminaries may be mounted in the upper chamber or operating chamber of the rigid body.
  • the light fittings may be removable from the rigid body and replaced (for example) with ultra-violet light fittings in the original setting whilst the module is in normal operational mode.
  • the light fittings may be removable from a front or top face of the module.
  • the lighting pod may be removable for changing damaged light fittings or changing to (for example) ultra-violet lights for certain process applications before, during or after operation of the isolator.
  • the lighting pod is a tube or shaped form constructed from a clear material (eg plastic acrylic or glass) suitably sealed to the rigid body. Within the lighting pod is a smaller item that includes the lights, starter capacitor and other required wiring and components such as a plug or twist fit connector.
  • the lighting pod is capped off by a lid and secured in a closed position on the front face of the isolator.
  • Any number of light fittings my be used to obtain the relevant amount of light and light distribution in the processing zone.
  • the removable section of the light fitting may adopt a "Y" or "X" shape where the uppermost section of the Y or X includes the lighting components and other sections contain tube lights.
  • the surface upon which the lights are mounted may be of a reflective material providing a greater distribution and diffusion of light.
  • the modular isolator may be mobile.
  • the exterior of the rigid body may be fitted with a plurality of mobility means for rendering the modular isolator mobile (eg castors).
  • a plurality of mobility means for rendering the modular isolator mobile eg castors
  • each means for rendering the modular isolator mobile is mounted on the end of an elongate member (eg a steel frame leg).
  • the modular isolator comprises a plurality of castors mounted at suitable locations at the ends or comers of the base of the rigid body for effective mobility.
  • Suitable shelving or other storage means may be provided in the processing zone ( eg in the operating chamber).
  • the modular isolator is configured to permit the operator to reach into the processing zone (eg to conduct the process or processes for which the isolator is designed) from a seating position.
  • the modular isolator is adapted to fit through industry standard doors (eg through a standard door height ( eg 1950mm)).
  • the modulator isolator may further comprise: a housing for mechanical and electrical and/or electronic components to facilitate the operation of the isolator and/or required airflow characteristics.
  • the modular isolator of the invention may be used to conduct processes such as transfer of hazardous products, sterility testing, processing pharmaceutical, biotechnology and/or medical products, laboratory testing, packaging and other processing applications within the pharmaceutical, biotechnology and related fields.
  • the versatility of the modular isolator is such that conjoined modules may be used to carry out complimentary steps of a process eg sterility testing in a first module and packaging in a second, conjoined module.
  • each module per se is such that a single one is usable in isolation or in confined or restrictive locations ( eg around an interior comer) with optimum ergonomic performance.
  • the module per se is independently patentable.
  • the present invention provides a module as hereinbefore defined.
  • the module may be used in isolation or abutted (for example) directly against an interior corner wall.
  • the module may be conjoined with a single connecting module (or more than one linearly conjoined connecting modules) and use in isolation or abutted against an interior corner wall.
  • FIGS 1 to 6 illustrate various views of an embodiment of the module of the invention 1 which comprises a rigid body 100.
  • the upper portion of the front face 1a of the rigid body 100 is essentially bifaceted ( ie with first and second exterior faces 1b and 1c) so that its external surface adopts a quarter octagonal configuration defining internally a processing zone 2 which is substantially quadrantal.
  • Two transparent clear plastic (or glass) barrier doors 3a and 3b are attached respectively to the first and second exterior faces 1a and 1b.
  • Each door 3a and 3b is provided with a single or double hinge 4 for opening in a horizontal plane (but it will be appreciated that the hinge could equally be provided on an upper edge for opening in a vertical plane).
  • the doors 3a and 3b are provided with a door locking mechanism 200 comprising a rotating rod 200a extending into a specified fixing and locking point 200b.
  • a seal (not shown) runs around the outer circumference of the door 3a, 3b acting against the door frame along the direction of the doors height and width but not the doors thickness and locks itself into a groove on the doorframe ensuring a good seal and acting as a door locking mechanism.
  • a seal hose connection 5 and hydraulic/pneumatic components serve to inflate and deflate the seal as required.
  • a control section 8 houses user or maintenance interface components and is closed by door 20.
  • a process equipment bay 9 houses specified equipment to facilitate desired operations. Process equipment may be located and installed in a process equipment bay 10 specifically catering for standard components such as a Millipore integral sterility testing system.
  • a touch panel user interface 11 includes digital and analogue feedback on isolator performance and processes, alongside a full control interface for processes and applications.
  • a motor section cover 15 covering inter alia air flow dynamics control valves and piping 25.
  • An internal wall 39 and parallel side walls define an operating chamber 16 with provision for shelving and ensure PLF conditions to a pre-determined pressure and flow rate.
  • the operating chamber 16 is a perforated work platform 32 beneath which a lower chamber 33 defines a plenum.
  • the operating chamber 14 is also fitted with a removable lighting pod 28 encapsulated by a fully sealed clear plastic or glass light pod bay 30 and being fully sealed to enable interchange of light fittings during product processing without compromising sterility.
  • the lighting pod 28 may be fitted with non-standard light fittings (such as UV fittings) before, during or after a process.
  • a lighting pod power connector 38 is provided with a twist or plug action fitting.
  • a front handle 29 is provided for light pod removal using a twist locking mechanism.
  • Side panels 13 may be provided with rapid transfer ports (not shown) or other user specified equipment as required.
  • Five castors 12 are located on the base of the rigid body 100 for transportability.
  • An upper chamber 14 defines a plenum 26 (front section) and 37 (rear section) encasing an inlet filter 17 having dual functionality as a PLF screen and HEPA filtration unit. Access ports (not shown) may be located in the upper chamber 14, plenum (front section) 26 and/or plenum (rear section) 37.
  • a gel sealing section 18 is provided for the inlet filter 17 using knife edge gel seal technology.
  • Airflow is controlled by a high power dual scroll centrifugal fan 22 with integral motor mounted on a motor mounting 23 and supply air valves 21 downstream thereof.
  • Return filter bays 24 in the lower chamber 33 encapsulate a return filter 42 (a HEPA filtration panel) with a knife edge seal 43 in which gel is applied to the return filter 42 itself and a handle 31 for sealing and locking the return filter 42.
  • the handle 31 extends from a plate 31a covering the gap between the return filter 42 and the return filter bays 24 and a wedge section 34 on the plate 31a is positioned against locking lugs 35 to seal and clamp the return filter 42 in place.
  • FIG. 7 illustrates schematically various embodiments of a modular isolator of the invention in which modules as described with reference to Figures 1-6 have been arranged in various configurations and locations:

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EP03257430A 2002-11-29 2003-11-25 Isolator Withdrawn EP1426122A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0227874 2002-11-29
GB0227874A GB0227874D0 (en) 2002-11-29 2002-11-29 Isolator

Publications (1)

Publication Number Publication Date
EP1426122A1 true EP1426122A1 (de) 2004-06-09

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EP03257430A Withdrawn EP1426122A1 (de) 2002-11-29 2003-11-25 Isolator

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GB (1) GB0227874D0 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005061787A1 (de) * 2005-12-23 2007-06-28 Fette Gmbh Vorrichtung zur Erzeugung eines Unterdrucks im abgedichteten Raum einer Tablettenpresse und/oder eines Isolators
WO2011085735A1 (de) * 2010-01-13 2011-07-21 Metall + Plastic Gmbh Dekontaminationsanordnung sowie verfahren

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4832753A (en) * 1987-05-21 1989-05-23 Tempress Measurement & Control Corporation High-purity cleaning system, method, and apparatus
US5219215A (en) * 1991-12-03 1993-06-15 Intelmatec Corporation Modular clean bench system
EP0604925A1 (de) * 1992-12-31 1994-07-06 Metall + Plastic GmbH Verfahren zur Luftführung in einem Aufnahmeraum sowie Vorrichtung zum Bearbeiten von Kleinteilen
US5487768A (en) * 1994-01-31 1996-01-30 Zytka; Donald J. Minienvironment for material handling
JP2000085961A (ja) * 1998-09-09 2000-03-28 Shin Meiwa Ind Co Ltd クリーン作業装置

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4832753A (en) * 1987-05-21 1989-05-23 Tempress Measurement & Control Corporation High-purity cleaning system, method, and apparatus
US5219215A (en) * 1991-12-03 1993-06-15 Intelmatec Corporation Modular clean bench system
EP0604925A1 (de) * 1992-12-31 1994-07-06 Metall + Plastic GmbH Verfahren zur Luftführung in einem Aufnahmeraum sowie Vorrichtung zum Bearbeiten von Kleinteilen
US5487768A (en) * 1994-01-31 1996-01-30 Zytka; Donald J. Minienvironment for material handling
JP2000085961A (ja) * 1998-09-09 2000-03-28 Shin Meiwa Ind Co Ltd クリーン作業装置

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 2000, no. 06 22 September 2000 (2000-09-22) *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005061787A1 (de) * 2005-12-23 2007-06-28 Fette Gmbh Vorrichtung zur Erzeugung eines Unterdrucks im abgedichteten Raum einer Tablettenpresse und/oder eines Isolators
WO2011085735A1 (de) * 2010-01-13 2011-07-21 Metall + Plastic Gmbh Dekontaminationsanordnung sowie verfahren
CN102792100A (zh) * 2010-01-13 2012-11-21 金属塑料有限责任公司 净化设备和方法
EP2535650A1 (de) * 2010-01-13 2012-12-19 Metall + Plastic GmbH Dekontaminationsanordnung sowie Verfahren
EP3067633A1 (de) * 2010-01-13 2016-09-14 Metall + Plastic GmbH Dekontaminationsverfahren

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