EP1402849B2 - Stent à surface rugueuse et sa méthode de fabrication - Google Patents

Stent à surface rugueuse et sa méthode de fabrication Download PDF

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Publication number
EP1402849B2
EP1402849B2 EP02021067A EP02021067A EP1402849B2 EP 1402849 B2 EP1402849 B2 EP 1402849B2 EP 02021067 A EP02021067 A EP 02021067A EP 02021067 A EP02021067 A EP 02021067A EP 1402849 B2 EP1402849 B2 EP 1402849B2
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EP
European Patent Office
Prior art keywords
stent
roughened
sandblasting
drug
imperfections
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP02021067A
Other languages
German (de)
English (en)
Other versions
EP1402849A1 (fr
EP1402849B1 (fr
Inventor
Albert Prof. Dr. Schömig
Adnan Prof. Dr. Kastrati
Randolf Dr. Von Oepen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kastrati Adnan
SCHOEMIG, ALBERT
Abbott Laboratories Vascular Enterprises Ltd
Original Assignee
Kastrati Adnan
Schomig Albert
Abbott Laboratories Vascular Enterprises Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
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Application filed by Kastrati Adnan, Schomig Albert, Abbott Laboratories Vascular Enterprises Ltd filed Critical Kastrati Adnan
Priority to AT02021067T priority Critical patent/ATE392864T1/de
Priority to EP02021067A priority patent/EP1402849B2/fr
Priority to DE60226236T priority patent/DE60226236T3/de
Priority to US10/528,352 priority patent/US20060155361A1/en
Priority to JP2004537145A priority patent/JP2005538790A/ja
Priority to PCT/EP2003/010542 priority patent/WO2004026177A1/fr
Priority to AU2003271633A priority patent/AU2003271633A1/en
Priority to CA2497602A priority patent/CA2497602C/fr
Publication of EP1402849A1 publication Critical patent/EP1402849A1/fr
Publication of EP1402849B1 publication Critical patent/EP1402849B1/fr
Application granted granted Critical
Publication of EP1402849B2 publication Critical patent/EP1402849B2/fr
Priority to US14/135,257 priority patent/US20140180433A1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B24—GRINDING; POLISHING
    • B24C—ABRASIVE OR RELATED BLASTING WITH PARTICULATE MATERIAL
    • B24C1/00—Methods for use of abrasive blasting for producing particular effects; Use of auxiliary equipment in connection with such methods
    • B24C1/06—Methods for use of abrasive blasting for producing particular effects; Use of auxiliary equipment in connection with such methods for producing matt surfaces, e.g. on plastic materials, on glass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B24—GRINDING; POLISHING
    • B24C—ABRASIVE OR RELATED BLASTING WITH PARTICULATE MATERIAL
    • B24C1/00—Methods for use of abrasive blasting for producing particular effects; Use of auxiliary equipment in connection with such methods
    • B24C1/08—Methods for use of abrasive blasting for producing particular effects; Use of auxiliary equipment in connection with such methods for polishing surfaces, e.g. smoothing a surface by making use of liquid-borne abrasives
    • B24C1/083—Deburring
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B24—GRINDING; POLISHING
    • B24C—ABRASIVE OR RELATED BLASTING WITH PARTICULATE MATERIAL
    • B24C1/00—Methods for use of abrasive blasting for producing particular effects; Use of auxiliary equipment in connection with such methods
    • B24C1/10—Methods for use of abrasive blasting for producing particular effects; Use of auxiliary equipment in connection with such methods for compacting surfaces, e.g. shot-peening
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0076—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof multilayered, e.g. laminated structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment

Definitions

  • the present invention relates generally to stents which are implantable or deployable in a vascular or endoluminal location within the body of a patient to maintain the lumen open and unoccluded at that location, and in particular to improvements in stents.
  • stents are widely used for numerous applications where the stent is placed in the lumen of a patient and expanded.
  • Said stents may be used in coronary or other vasculature as well as within the urinary tract, the bial tract and the intestinal tract among other body passageways and conduits.
  • stents are cylindrical members which are expanded from reduced diameters to enlarged diameters. Frequently, such stents are placed on a balloon catheter with the stent in a reduced diameter state. To prevent that the balloon is damaged because of sharp corners and burrs on the surface of the stent and further to avoid thrombus formation, stents are highly polished. This is done for example by sandblasting the surface to remove said imperfections and polishing the stent afterwards to get a smooth surface.
  • the balloon catheder mounted stent can be dislodged from the uninflated balloon as a result of the navigation through the vessel of the body to the preselected site for deployment because of the highly polished surface.
  • the polished and smooth surface used to avoid thrombus formation has the disadvantage, that endothelial cells have difficulties to ingrow the stent which can result in that restenosis occurs.
  • some stents are sandblasted on their interior surface to improve stent retention on the balloon.
  • a stent is disclosed, wherein the exterior surface of the stent is polished such that a smooth surface finish is achieved.
  • the interior surface having a rough surface finish is rougher than the surface finish of the exterior surface to enhance the friction between the stent and the balloon.
  • a stent which is provided with a first layer of nobel metal. Further a second outermost layer is provided which is composed of a ceramic like metal such as iridium oxid or titanium nitrate. The second layer is formed with a rough surface to provide an increased friction factor and retention on a balloon during advancement of the stent delivery system through the vessel.
  • a stent comprising a surface which is coated with a ceramic material to achieve a rough surface.
  • a further thin layer can be provided comprising a drug wherein the layer is biologically degraded and whereby the drug is gradually released.
  • a stent wherein a portion of a stent supporting structure is encapsulated with a thin flexible coating made of a polymer which can be used as a carrier for supporting therapeutic agents and drugs. Furthermore, the supporting structure, preferably only the portion which is not encapsulated by the thin flexible coating, is further processed to form a porous exterior surface. Said porous exterior surface renders the exposed portions of the supporting structure, such as the proximal and distal ends more biocompatible by promoting tissue in-growth while reducing the formation of blood clots.
  • Said stents of the prior art have the disadvantage that they are complicated to manufacture and expensive.
  • the object of the present invention is therefore to provide an improved stent, which can be manufactured at low costs and which can further avoid thrombus formation and a stenosis.
  • a stent comprising at least an outer surface portion which is roughened to a predetermined extent and wherein a drug or a therapeutic agent can be applied to said surface.
  • the stent does not have to be provided with an additional drug deposit e.g. a polymer layer suitable to carry a drug or therapeutic agent.
  • the drug can be applied directly to the rough surface and released over a predetermined time after the stent has been placed in a desired location of a lumen.
  • a roughened exterior surface decrease in-stent restenosis, since cells can attach more easily to said surface than to a smooth one which results in that endothelial ingrowth is accelerated.
  • Intima cells can grow on the rough surface and attach themselves, wherein the endothelialization of the vessel or lumen is promoted.
  • the endothelial cell layer is very smooth and therefore thrombus formation and a stenosis can be avoided.
  • the drug e.g. Tacrolimus is applied to the rough surface by spraying. This has the advantage, that the application of the drug is effective, simple and inexpensive.
  • imperfections such as e.g. burrs are removed before at least a portion of the surface of the stent is roughened. This has the advantage that the surface can be roughened more uniform which leads to better flow dynamics. Thus less turbulences can occur on the surface which results in a reduction of restenosis.
  • the surface is roughened to a predetermined extent by sandblasting. Moreover, sandblasting results in an improvement of the fatigue behaviour. Further the durability of the stent and the surface bonding can be improved.
  • the rough surface also provides an increased surface area for an attachment of a drug or therapeutic agent. Further a stent with a thinner wall with higher radial force and therefore less material can be achieved which also leads to a decrease of restenosis. With sandblasting the surface can be better controlled and produced and further a more uniform and trauma less surface can be achieved.
  • corundum for sandblasting results in a surface which is technically different from a normal sandblasted surface. It has the advantage that less energy has to be used and/or less time for this finishing sandblasting than for a sandblasting process to remove burrs. Further the sandblasted surface has less depth with regard to the "cavities". Furthermore the chemical behaviour of such a stent is different from commonly known electropolished stents. The surface chemistry is different due to the incorporation of sand particles into the surface. An immediately repassivated surface leads to more chemically stable passive layers than surfaces which have been passivated in equilibrium.
  • the stent is annealed after the surface has been roughened to a predetermined extent to make him more flexible.
  • the complete surface i.e. exterior surface, interior surface and side surfaces, is sandblasted by using corundum. It is obvious that the invention is not limited to said embodiment and that also only portions of the surface can be roughened as claimed.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Prostheses (AREA)

Claims (18)

  1. Stent vasculaire pour la mise en place dans une lumière corporelle, ledit stent étant expansible a partir d'un état contracté jusqu'a un état dilaté et comprenant :
    a) une surface extérieure, une surface intérieure et des surfaces latérales,
    b) dans lequel au moins une partie de la surface extérieure et de la surface intérieure est rendue rugueuse jusqu'à une étendue prédéterminée, pour être revêtue d'un médicament, les surfaces étant rendues rugueuses par une opération de sablage.
  2. Stent selon la revendication 1, comprenant au moins une portion des surfaces latérales qui est rendue rugueuse jusqu'à une étendue prédéterminée.
  3. Stent selon la revendication 1 ou la revendication 2, dans lequel la surface est rendue rugueuse par une opération de sablage, avec du sable, des billes de verre ou du corindon.
  4. Stent selon l'une quelconque des revendications 1 à 3, dans lequel la surface extérieure et/ou la surface intérieure et/ou les surfaces latérales sont revêtues d'un médicament, de préférence du Tacrolimus.
  5. Stent selon l'une quelconque des revendications 1 a 4, dans lequel ledit stent comprend un acier inoxydable.
  6. Dispositif à cathéter à ballonnet pour l'insertion d'un stent tubulaire, comprenant un stent tel que défini dans l'une quelconque des revendications 1 à 5.
  7. Procédé pour la fabrication d'un stent vasculaire pour la mise en place dans une lumière corporelle, ledit procédé comprenant les étapes suivantes :
    a) formation d'un tube qui peut être employé depuis un état contracté jusqu'à un état dilaté, ledit stent ayant une surface extérieure, une surface intérieure et des surfaces latérales,
    b) opération consistant à rendre rugueuse au moins une partie de la surface extérieure et de la surface intérieure jusqu'à une étendue prédéterminée, les surfaces étant rendues rugueuses par sablage,
    c) revêtement de ladite surface d'un médicament.
  8. Procédé selon la revendication 7, dans lequel au moins une partie des surfaces latérales est rendue rugueuse jusqu'à une étendue prédéterminée.
  9. Procédé selon l'une quelconque des revendications 7 et 8, comprenant une étape supplémentaire d) après l'étape a) dans laquelle des imperfections, telles que des bords tranchants et des bavures, sont enlevées de la surface du tube.
  10. Procédé selon la revendication 9, dans lequel les imperfections sont enlevées par ébavurage.
  11. Procédé selon la revendication 9 ou la revendication 10, dans lequel les imperfections sont enlevées par électropolissage.
  12. Procédé selon l'une quelconque des revendications 9 à 11, dans lequel les imperfections sont enlevées par sablage.
  13. Procédé selon l'une quelconque des revendications 7 à 12, dans lequel le sable est utilisé pour l'opération de sablage.
  14. Procédé selon l'une quelconque des revendications 7 à 13, dans lequel on utilise des billes de verre pour le sablage.
  15. Procédé selon l'une quelconque des revendications 7 à 14, dans lequel on utilise du corindon pour le sablage.
  16. Procédé selon l'une quelconque des revendications 7 à 15, dans lequel le médicament est le Tacrolimus.
  17. Procédé selon l'une quelconque des revendications 7 à 16, dans lequel le médicament est appliqué par pulvérisation sur la surface rendue rugueuse.
  18. Procédé selon l'une quelconque des revendications 7 à 17, dans lequel le tube est recuit.
EP02021067A 2002-09-20 2002-09-20 Stent à surface rugueuse et sa méthode de fabrication Expired - Lifetime EP1402849B2 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AT02021067T ATE392864T1 (de) 2002-09-20 2002-09-20 Mit einer rauhen oberfläche versehener stent und sein herstellungsverfahren
EP02021067A EP1402849B2 (fr) 2002-09-20 2002-09-20 Stent à surface rugueuse et sa méthode de fabrication
DE60226236T DE60226236T3 (de) 2002-09-20 2002-09-20 Mit einer rauhen Oberfläche versehener Stent und sein Herstellungsverfahren
AU2003271633A AU2003271633A1 (en) 2002-09-20 2003-09-22 Stent with rough surface and its manufacture
JP2004537145A JP2005538790A (ja) 2002-09-20 2003-09-22 粗表面を有するステント及びその製造
PCT/EP2003/010542 WO2004026177A1 (fr) 2002-09-20 2003-09-22 Endoprothese pourvue d'une surface rugueuse et sa production
US10/528,352 US20060155361A1 (en) 2002-09-20 2003-09-22 Stent with rough surface and its manufacture
CA2497602A CA2497602C (fr) 2002-09-20 2003-09-22 Endoprothese pourvue d'une surface rugueuse et sa production
US14/135,257 US20140180433A1 (en) 2002-09-20 2013-12-19 Stent with rough surface and its manufacture

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02021067A EP1402849B2 (fr) 2002-09-20 2002-09-20 Stent à surface rugueuse et sa méthode de fabrication

Publications (3)

Publication Number Publication Date
EP1402849A1 EP1402849A1 (fr) 2004-03-31
EP1402849B1 EP1402849B1 (fr) 2008-04-23
EP1402849B2 true EP1402849B2 (fr) 2011-03-16

Family

ID=31970283

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02021067A Expired - Lifetime EP1402849B2 (fr) 2002-09-20 2002-09-20 Stent à surface rugueuse et sa méthode de fabrication

Country Status (8)

Country Link
US (2) US20060155361A1 (fr)
EP (1) EP1402849B2 (fr)
JP (1) JP2005538790A (fr)
AT (1) ATE392864T1 (fr)
AU (1) AU2003271633A1 (fr)
CA (1) CA2497602C (fr)
DE (1) DE60226236T3 (fr)
WO (1) WO2004026177A1 (fr)

Cited By (14)

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US8187620B2 (en) 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
US8231980B2 (en) 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
US8287937B2 (en) 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese
US8353949B2 (en) 2006-09-14 2013-01-15 Boston Scientific Scimed, Inc. Medical devices with drug-eluting coating
US8431149B2 (en) 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8449603B2 (en) 2008-06-18 2013-05-28 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8574615B2 (en) 2006-03-24 2013-11-05 Boston Scientific Scimed, Inc. Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8771343B2 (en) 2006-06-29 2014-07-08 Boston Scientific Scimed, Inc. Medical devices with selective titanium oxide coatings
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
US8815273B2 (en) 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
US8900292B2 (en) 2007-08-03 2014-12-02 Boston Scientific Scimed, Inc. Coating for medical device having increased surface area
US8920491B2 (en) 2008-04-22 2014-12-30 Boston Scientific Scimed, Inc. Medical devices having a coating of inorganic material
US8932346B2 (en) 2008-04-24 2015-01-13 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
US9284409B2 (en) 2007-07-19 2016-03-15 Boston Scientific Scimed, Inc. Endoprosthesis having a non-fouling surface

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US7713297B2 (en) 1998-04-11 2010-05-11 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
AU2002345328A1 (en) 2001-06-27 2003-03-03 Remon Medical Technologies Ltd. Method and device for electrochemical formation of therapeutic species in vivo
US7901451B2 (en) 2004-09-24 2011-03-08 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method for treating restenosis
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
US8048150B2 (en) 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
EP2054537A2 (fr) 2006-08-02 2009-05-06 Boston Scientific Scimed, Inc. Endoprothèse avec contrôle tridimensionnel de désintégration
JP2010503485A (ja) 2006-09-15 2010-02-04 ボストン サイエンティフィック リミテッド 医療用デバイスおよび同デバイスの製造方法
US8808726B2 (en) 2006-09-15 2014-08-19 Boston Scientific Scimed. Inc. Bioerodible endoprostheses and methods of making the same
EP2399616A1 (fr) 2006-09-15 2011-12-28 Boston Scientific Scimed, Inc. Endoprothèse bio-érodable dotée de couches inorganiques biostables
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DE60226236T3 (de) 2011-12-15
AU2003271633A1 (en) 2004-04-08
EP1402849A1 (fr) 2004-03-31
DE60226236D1 (de) 2008-06-05
CA2497602A1 (fr) 2004-04-01
EP1402849B1 (fr) 2008-04-23
CA2497602C (fr) 2012-11-20
ATE392864T1 (de) 2008-05-15
WO2004026177A1 (fr) 2004-04-01
US20140180433A1 (en) 2014-06-26
DE60226236T2 (de) 2009-07-23
US20060155361A1 (en) 2006-07-13
JP2005538790A (ja) 2005-12-22

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