EP1399538A4 - TECHOLOGISCHE MANIPULATION INTRAZELLULäRER SIALIERUNGSWEGE - Google Patents
TECHOLOGISCHE MANIPULATION INTRAZELLULäRER SIALIERUNGSWEGEInfo
- Publication number
- EP1399538A4 EP1399538A4 EP00913684A EP00913684A EP1399538A4 EP 1399538 A4 EP1399538 A4 EP 1399538A4 EP 00913684 A EP00913684 A EP 00913684A EP 00913684 A EP00913684 A EP 00913684A EP 1399538 A4 EP1399538 A4 EP 1399538A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- methods
- interest
- cells
- carbohydrate
- pathways
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01052—Beta-N-acetylhexosaminidase (3.2.1.52)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12258299P | 1999-03-02 | 1999-03-02 | |
US122582P | 1999-03-02 | ||
US16962499P | 1999-12-08 | 1999-12-08 | |
US169624P | 1999-12-08 | ||
PCT/US2000/005313 WO2000052135A2 (en) | 1999-03-02 | 2000-03-01 | Engineering intracellular sialylation pathways |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1399538A2 EP1399538A2 (de) | 2004-03-24 |
EP1399538A4 true EP1399538A4 (de) | 2004-03-24 |
Family
ID=26820692
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00913684A Withdrawn EP1399538A4 (de) | 1999-03-02 | 2000-03-01 | TECHOLOGISCHE MANIPULATION INTRAZELLULäRER SIALIERUNGSWEGE |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1399538A4 (de) |
JP (1) | JP2003524395A (de) |
AU (1) | AU3508300A (de) |
CA (1) | CA2363297C (de) |
WO (1) | WO2000052135A2 (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6949372B2 (en) | 1999-03-02 | 2005-09-27 | The Johns Hopkins University | Engineering intracellular sialylation pathways |
WO2001059075A1 (en) * | 2000-02-08 | 2001-08-16 | Genentech, Inc. | Improved sialylation of glycoproteins |
US7863020B2 (en) | 2000-06-28 | 2011-01-04 | Glycofi, Inc. | Production of sialylated N-glycans in lower eukaryotes |
KR101495616B1 (ko) | 2002-03-07 | 2015-02-26 | 아이드게노쉬쉐 테흐니쉐 호흐슐레 쥬리히 | 원핵 숙주에서의 재조합 글리코실화 단백질 생산 방법 및 생산계 |
CA2477794C (en) * | 2002-03-07 | 2013-08-20 | Eidgenoessische Technische Hochschule Zuerich | System and method for the production of recombinant glycosylated proteins in a prokaryotic host |
JP2006333701A (ja) * | 2003-01-15 | 2006-12-14 | Kazuhito Fujiyama | 動物型糖鎖をもつ糖タンパク質の生産方法 |
CN103627670B (zh) * | 2004-02-13 | 2016-12-21 | 格莱克托普有限公司 | 高活性糖蛋白加工条件及其有效生产方法 |
JP4932699B2 (ja) * | 2004-03-17 | 2012-05-16 | グライコフィ, インコーポレイテッド | 真菌および酵母におけるシチジンモノホスフェート−シアル酸合成経路を操作する方法 |
WO2005105156A1 (en) * | 2004-05-04 | 2005-11-10 | National University Of Singapore | Method for expressing sialylated glycoproteins in mammalian cells and cells thereof |
US7479549B2 (en) | 2005-02-23 | 2009-01-20 | Jaques John Scott T | Recombinant canine thyroid stimulating hormone and methods of production and use thereof |
PT1888761E (pt) | 2005-05-11 | 2011-01-03 | Eth Zuerich | Proteínas n-glicosiladas recombinantes de células procarióticas |
WO2007006570A2 (en) * | 2005-07-12 | 2007-01-18 | Greenovation Biotech Gmbh | Improvements in or relating to protein production |
NZ575974A (en) | 2006-09-10 | 2012-03-30 | Glycotope Gmbh | Use of human cells of myeloid leukaemia origin for expression of antibodies |
EP1920782A1 (de) | 2006-11-10 | 2008-05-14 | Glycotope Gmbh | Mikroorganismen oder deren Fraktionen fähig zur Aktivierung von Zelleimmunität gegen Kohlenhydrate |
CN101983070B (zh) | 2008-02-20 | 2016-03-30 | 格林考瓦因有限公司 | 由来源于原核细胞的重组n-糖基化蛋白制备生物共轭物 |
PT2501406T (pt) | 2009-11-19 | 2018-02-21 | Glaxosmithkline Biologicals Sa | Sistema de biossíntese que produz polissacáridos imunogénicos em células procariotas |
WO2011138361A1 (en) | 2010-05-06 | 2011-11-10 | Glycovaxyn | Capsular gram-positive bacteria bioconjugate vaccines |
EP2412815A1 (de) * | 2010-07-27 | 2012-02-01 | Universite De Rouen | N-Glykosylierung in transformiertem Phaeodactylum tricornutum |
WO2012050175A1 (ja) * | 2010-10-15 | 2012-04-19 | 日本ケミカルリサーチ株式会社 | 糖鎖の非還元末端がマンノース残基である糖蛋白質の製造方法 |
ES2686313T3 (es) | 2011-08-22 | 2018-10-17 | Glycotope Gmbh | Microorganismos que portan un antígeno tumoral |
JP6652334B2 (ja) † | 2014-05-31 | 2020-02-19 | Jcrファーマ株式会社 | ウリジンとn−アセチル−d−マンノサミンとを含有する培地 |
SI3794042T1 (sl) | 2018-05-18 | 2024-07-31 | Daiichi Sankyo Co., Ltd. | Konjugat protitelesa anti-MUC1-exatecan in citotoksično sredstvo |
-
2000
- 2000-03-01 JP JP2000602747A patent/JP2003524395A/ja not_active Withdrawn
- 2000-03-01 AU AU35083/00A patent/AU3508300A/en not_active Abandoned
- 2000-03-01 EP EP00913684A patent/EP1399538A4/de not_active Withdrawn
- 2000-03-01 CA CA2363297A patent/CA2363297C/en not_active Expired - Lifetime
- 2000-03-01 WO PCT/US2000/005313 patent/WO2000052135A2/en active Application Filing
Non-Patent Citations (3)
Title |
---|
GU XUEJUN ET AL: "Improvement of interferon-gamma sialylation in Chinese hamster ovary cell culture by feeding of N-acetylmannosamine", BIOTECHNOLOGY AND BIOENGINEERING, INTERSCIENCE PUBLISHERS, LONDON, GB, vol. 58, no. 6, 20 June 1998 (1998-06-20), pages 642 - 648, XP002171407, ISSN: 0006-3592 * |
OGONAH O W ET AL: "ISOLATION AND CHARACTERIZATION OF AN INSECT CELL LINE ABLE TO PERFORM COMPLEX N-LINKED GLYCOSYLATION ON RECOMBINANT PROTEINS", BIOTECHNOLOGY, BUTTERWORTHS, LONDON, GB, vol. 14, February 1996 (1996-02-01), pages 197 - 202, XP000961423, ISSN: 0740-7378 * |
See also references of WO0052135A3 * |
Also Published As
Publication number | Publication date |
---|---|
WO2000052135A3 (en) | 2004-01-08 |
WO2000052135A9 (en) | 2001-10-11 |
CA2363297C (en) | 2011-08-09 |
JP2003524395A (ja) | 2003-08-19 |
WO2000052135A2 (en) | 2000-09-08 |
CA2363297A1 (en) | 2000-09-08 |
AU3508300A (en) | 2000-09-21 |
EP1399538A2 (de) | 2004-03-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20011001 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20020827 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
17Q | First examination report despatched |
Effective date: 20080717 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20090128 |