EP1386169A1 - Three-dimensional microfluidics incorporating passive fluid control structures - Google Patents

Three-dimensional microfluidics incorporating passive fluid control structures

Info

Publication number
EP1386169A1
EP1386169A1 EP02726572A EP02726572A EP1386169A1 EP 1386169 A1 EP1386169 A1 EP 1386169A1 EP 02726572 A EP02726572 A EP 02726572A EP 02726572 A EP02726572 A EP 02726572A EP 1386169 A1 EP1386169 A1 EP 1386169A1
Authority
EP
European Patent Office
Prior art keywords
layers
channel
microfluidic
layer
microfluidic device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02726572A
Other languages
German (de)
English (en)
French (fr)
Inventor
Michael R. Mcneely
Mark K Spute
Nils Adey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biomicro Systems Inc
Original Assignee
Biomicro Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomicro Systems Inc filed Critical Biomicro Systems Inc
Priority claimed from PCT/US2002/004045 external-priority patent/WO2003052428A1/en
Publication of EP1386169A1 publication Critical patent/EP1386169A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F28—HEAT EXCHANGE IN GENERAL
    • F28F—DETAILS OF HEAT-EXCHANGE AND HEAT-TRANSFER APPARATUS, OF GENERAL APPLICATION
    • F28F2260/00—Heat exchangers or heat exchange elements having special size, e.g. microstructures
    • F28F2260/02—Heat exchangers or heat exchange elements having special size, e.g. microstructures having microchannels

Definitions

  • Another object of the invention is to provide a multi-layered microfluidic device that includes active components such as electrodes, heating elements, or sensors.
  • channel narrowings can be implemented between two layers, as shown in FIGS. 16 and 17, or within a single layer, as shown in FIGS. 18-20, if the layer thickness and manufacturing technique permit structures to be formed in both faces of the layer.
  • the mixer circuit depicted in FIGS. 25A-25D can also be implemented in multiple thin layers. If multiple thin layers are used such that fluid circuit structures are cut through entire layer thicknesses, the "island" of material surrounded by the main channel and the side chamiel will be unsupported, which may complicate manufacturing.
  • the circuit may thus be formed in multiple layers 720-724 as shown in FIG. 26. Fluid enters at opening 725 in layer 720. Main channel 726 and side channel 727 are formed in layer 721, as is passive valve 728. Small opening 729 in layer 722 forms the passive valve just before the intersection of side channel 727 with main channel 726. The side and main channels come together at channel 731 in layer 723.
  • FIG. 3 A depicts a three-dimensional microfluidic device 300 that performs serial dilution of a sample and delivers sample solutions and a series of appropriate reagents/reactants to a diagnostic surface 303 for the performance of a multiplexed immunoassay, e.g., an Enzyme Linked Immuno-absorbent Assay or "ELISA".
  • the microfluidic circuit is designed to interface with a diagnostic surface 303 such as a slide or microtiter plate having small regions 3181-318e containing immobilized capture antibodies specific for a analyte(s) of interest.
  • the device has been simplified to more clearly illustrate its principles of operation.

Landscapes

  • Engineering & Computer Science (AREA)
  • Manufacturing & Machinery (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
EP02726572A 2001-02-07 2002-02-07 Three-dimensional microfluidics incorporating passive fluid control structures Withdrawn EP1386169A1 (en)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US26715401P 2001-02-07 2001-02-07
US267154P 2001-02-07
US27438901P 2001-03-09 2001-03-09
US274389P 2001-03-09
US28442701P 2001-04-17 2001-04-17
US284427P 2001-04-17
US29020901P 2001-05-11 2001-05-11
US290209P 2001-05-11
US31370301P 2001-08-20 2001-08-20
US313703P 2001-08-20
US33985101P 2001-12-12 2001-12-12
US339851P 2001-12-12
PCT/US2002/004045 WO2003052428A1 (en) 2001-02-07 2002-02-07 Three-dimensional microfluidics incorporating passive fluid control structures

Publications (1)

Publication Number Publication Date
EP1386169A1 true EP1386169A1 (en) 2004-02-04

Family

ID=30119501

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02726572A Withdrawn EP1386169A1 (en) 2001-02-07 2002-02-07 Three-dimensional microfluidics incorporating passive fluid control structures

Country Status (4)

Country Link
EP (1) EP1386169A1 (ja)
JP (1) JP2005513441A (ja)
KR (1) KR20030090636A (ja)
AU (1) AU2002256996A1 (ja)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100612879B1 (ko) * 2004-12-06 2006-08-14 삼성전자주식회사 폐쇄 시스템에서 펌프와 밸브의 제어를 통한 혼성화 장치
KR100612880B1 (ko) * 2004-12-06 2006-08-14 삼성전자주식회사 챔버 샘플투입구의 패킹 장치
KR100644807B1 (ko) * 2004-12-10 2006-11-14 한국전자통신연구원 플라스틱 기판을 이용한 미소 가열기 및 그의 제조 방법
JP2006326474A (ja) * 2005-05-25 2006-12-07 Photo Precision Kk 積層チップ
WO2007049534A1 (ja) * 2005-10-28 2007-05-03 Arkray, Inc. 送液方法、およびこれに用いるカートリッジ
MX342351B (es) 2005-12-21 2016-09-26 Meso Scale Technologies Llc Modulos de ensayo que tienen reactivos de ensayo y metodos para hacer y utilizar los mismos.
JP5845156B2 (ja) * 2005-12-21 2016-01-20 メソ スケール テクノロジーズ エルエルシー アッセイ試薬を具備するアッセイモジュールとその製造方法およびその使用方法
CA3122671A1 (en) 2005-12-21 2008-05-15 Meso Scale Technologies, Llc. Assay apparatuses, methods and reagents
KR100790881B1 (ko) * 2006-07-06 2008-01-02 삼성전자주식회사 미세유체 반응칩 및 이의 제조방법
US10753927B2 (en) 2006-09-22 2020-08-25 ALERE TECHNOLOGIES GmbH Methods for detecting an analyte
KR100758285B1 (ko) * 2006-09-27 2007-09-12 한국전자통신연구원 바이오 센서, 그 제조방법 및 이를 구비한 바이오 감지장치
EP2089159B1 (en) * 2007-05-03 2013-01-23 Clondiag GmbH Assays
JP4466682B2 (ja) * 2007-05-28 2010-05-26 株式会社日立プラントテクノロジー 流体混合装置
JP5241209B2 (ja) * 2007-11-26 2013-07-17 株式会社日立ハイテクノロジーズ 試料前処理用デバイス及び試料分析方法
JP5155800B2 (ja) * 2008-09-29 2013-03-06 富士フイルム株式会社 反応方法及び反応装置
WO2011003689A2 (en) * 2009-07-07 2011-01-13 Boehringer Ingelheim Microparts Gmbh Plasma separation reservoir
KR20110027419A (ko) 2009-09-10 2011-03-16 삼성전자주식회사 유체 수용 챔버, 유체 수용 챔버를 구비한 미세 유동 장치, 및 유체 혼합 방법
JPWO2014083799A1 (ja) * 2012-11-27 2017-01-05 日本電気株式会社 流体チップおよび流体の移送方法
EP3112869A1 (en) * 2015-06-30 2017-01-04 IMEC vzw Sensor device
KR102039230B1 (ko) * 2017-12-13 2019-10-31 인제대학교 산학협력단 버블 유입 방지용 시료주입 장치
WO2019107231A1 (ja) * 2017-11-29 2019-06-06 積水化学工業株式会社 マイクロ流体チップ

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO03052428A1 *

Also Published As

Publication number Publication date
JP2005513441A (ja) 2005-05-12
KR20030090636A (ko) 2003-11-28
AU2002256996A1 (en) 2003-06-30

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