EP1358011B1 - Systeme de fermeture pour recipient pour reactifs - Google Patents

Systeme de fermeture pour recipient pour reactifs Download PDF

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Publication number
EP1358011B1
EP1358011B1 EP02706718A EP02706718A EP1358011B1 EP 1358011 B1 EP1358011 B1 EP 1358011B1 EP 02706718 A EP02706718 A EP 02706718A EP 02706718 A EP02706718 A EP 02706718A EP 1358011 B1 EP1358011 B1 EP 1358011B1
Authority
EP
European Patent Office
Prior art keywords
closure
reagent container
conical insert
conical
wall
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP02706718A
Other languages
German (de)
English (en)
Other versions
EP1358011A2 (fr
Inventor
Reinhard Krause
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of EP1358011A2 publication Critical patent/EP1358011A2/fr
Application granted granted Critical
Publication of EP1358011B1 publication Critical patent/EP1358011B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/022—Capillary pipettes, i.e. having very small bore
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Definitions

  • the invention relates to a closure for reagent containers and a method for the removal of reagents with pipettes or pipetting needles.
  • liquid chemicals and various samples such as serum, plasma, cerebrospinal fluid, etc.
  • the removal takes place manually by means of e.g. a pipette or syringe or automatically e.g. through the pipetting needle of a pipetting machine.
  • the reagent containers In general, it is necessary to keep the reagent containers closed during storage so that the contents are not lost through evaporation, exposure to moisture, or aging by contact with air. Therefore, the reagent containers must be opened before taking a sample. After removal, the container must be closed again.
  • Screw caps must be manually or mechanically turned off prior to reagent picking and then screwed on again. This is expensive and can be performed by pipetting machines difficult.
  • the use of screw caps with a high throughput of containers can easily lead to confusion, since the lid must be set aside during removal. So it may happen that when closing a wrong lid is screwed. This in turn can lead to confusion of the contents of the container or impurities.
  • Plug closures have the same disadvantages as screw closures.
  • plug closures may e.g. in case of overpressure, loosen it in the vessel itself.
  • closures have a membrane made of plastic or eg latex compounds, which is pierced for sampling with a pipette or needle.
  • a flat membrane has been replaced by a cone-shaped inwardly extending indentation that can be punctured to remove fluid from the tip.
  • disadvantage of this type of closure is that the nature of the membrane often does not meet all the requirements placed on it. For one thing, it can be too sturdy to be punctured. On the other hand, it happens that the membrane no longer completely seals the container after the puncture.
  • closures are similar to the membrane closures.
  • a membrane, foil or plug is cut in a crosswise manner so that a pipette or needle can be inserted into the intersection of the incisions.
  • An example can be found in WO 90/09330 , Disadvantage of this method is that especially with multiple uses a tight closure of the container is no longer guaranteed.
  • chemical residues may also be deposited on the membrane when introducing and carrying out the pipette.
  • incorrect liquid detection e.g., in liquid detection by induction
  • a conductive surface such as a sample
  • immersion in the sample slides along the wet surface of a membrane. This can lead to the pipetting of air bubbles, for example.
  • the object of the present invention was therefore to find a closure for reagent containers, which is suitable for both manual and automatic sampling, which seals the container tight during storage and avoids contamination of the contents of the container during removal.
  • a closure having a screw or cap with a conical insert oriented in the direction of the contents.
  • the conical insert is cut at least once, so that it can be bent apart in the lower region, and additionally has in the middle region, for example, an annular web.
  • the cone completely closes the reagent container.
  • a pipette with a release sleeve ie a patch placed at a certain distance from the end of the needle thickening introduced.
  • the trigger sleeve hits on the bridge of the conical insert and thus causes a bending apart of the divided walls of the cone.
  • the pipetting needle enters the container without touching the cone, ie the closure. If the pipetting needle, together with the release sleeve, is withdrawn, the walls of the cone close again because the release sleeve no longer forces the bridge apart.
  • the vessel is sealed again.
  • the present invention also provides a pipetting device comprising at least one reagent container provided with a closure according to the invention and at least one pipette having a pipetting needle with a triggering sleeve.
  • illustration 1 shows a schematic representation of possible incisions of the conical insert.
  • Figure 2 shows a schematic representation of a closure according to the invention in closed (A) and opened (B) form.
  • the closure according to the invention is suitable for any type of reagent containers, which should be closed as tightly as possible during storage and on the other for the removal, in particular for multiple removal, should not be opened in an additional step.
  • these are reagent containers for chemical, biological or medical applications.
  • the closure is suitable for manual removal and more preferably for use in automatic pipetting.
  • the closure according to the invention comprises an attachment which allows the fixation on the reagent container.
  • This can be a screw or plug cap or, for example, also a sealing ring which is fastened by means of a metal clip.
  • it is a screw cap.
  • Attachment and conical insert may be made of one or more parts and materials.
  • the remainder of the closure may be made from a part consisting of a sealing ring and a conical insert.
  • the conical insert has a conical wall or pyramidal wall (i.e., a wall of at least three downwardly converging surfaces) with the apex of the cone or pyramid facing downwards, e.g. towards the contents of the reagent container.
  • the height and base area of the conical insert depend on the diameter and height of the reagent container to be closed. In order for the container to be able to absorb a sufficiently large amount of liquid, the insert should typically not protrude further than half the height of the container at most.
  • the conical insert has at least one incision, preferably 2 to 5 incisions.
  • a representation of possible arrangements of the incisions can be found in illustration 1 ,
  • the conical insert is shown schematically as a top view of the top of a cone.
  • the cuts are such that the wall of the insert from the top of the cone or the pyramid ago, preferably symmetrically, is completely severed. Thus, several flaps are created which form the lower part of the cone or pyramid to the top. Typically, the cuts do not extend to the top of the cone or pyramid.
  • the conical insert also has in the interior, ie on the side facing away from the contents of the container to be closed side trip bars on. These Trigger bars are typically located about halfway up the cone or pyramid.
  • the trigger bars are formed by a protuberance of the wall or by a bead placed on the wall. It may be a ring or, for example, several interrupted individual webs, which are located at a height of the cone or pyramid wall. In the case of multiple webs must be at least one ridge on each lobe of the wall, which is formed by the incisions, located. The incisions of the conical insert always reach beyond the trigger bar, so that the cone or the pyramid is already subdivided into several lobes at the level of the trigger bar.
  • the conical insert is incorporated or inserted centrally in the attachment part and extends vertically downwards into the interior of the vessel to be closed.
  • the attachment part is shaped such that it forms an extension of the neck of the vessel up and the conical insert of the closure according to the invention is within the attachment part and barely or not at all extends into the interior of the vessel.
  • the closure according to the invention is designed for vessels, e.g. be set obliquely in the template of a pipetting. Then the conical insert is preferably installed obliquely in the attachment part, or the entire closure according to the invention is aligned obliquely, so that a vertical pipetting is possible despite the inclined position of the vessel.
  • the closure of the invention may be made of plastic, metal, glass, ceramic or composite materials, which are composed mainly of said materials. Preferably, it consists of plastic. Attachment and conical insert may consist of the same or different materials. Furthermore, attachment and conical insert itself may consist of one or more materials. In particular, the conical insert For example, be provided on the side facing the vessel interior with a chemically inert coating, such as Teflon.
  • a pipette or syringe For proper liquid removal from a reagent container which is closed with a closure according to the invention, a pipette or syringe is typically used.
  • Their tip or needle hereinafter generally referred to as a pipetting needle, is provided with a triggering sleeve.
  • the triggering sleeve is a typically rod-shaped molding having a bore along the longitudinal axis into which the pipetting needle can be inserted.
  • the ends of the shaped body are preferably obliquely flattened or rounded.
  • the cross-section of the rod-shaped molding can e.g. represent a circle, an oval, a square or a triangle.
  • the size of the diameter of the shaped body may vary along the longitudinal axis of the rod so that it may be e.g. in the middle of the longitudinal axis has the largest diameter and becomes thinner towards the ends.
  • the release sleeve is particularly preferably a cylindrical shaped body with a round cross-section, whose cross-section decreases towards the ends.
  • the shape and size of the release sleeve must be matched to the size of the closure according to the invention and in particular the shape of the conical insert and the release bar.
  • the release sleeve is attached to the pipetting needle at a certain distance from the end of the needle.
  • the distance to the end of the needle and the extent (diameter and length) of the trigger sleeve is determined by the size and extent of the closure according to the invention.
  • the trigger sleeve must be designed and positioned so that upon insertion of the pipetting needle, the trigger sleeve touches the trigger bar of the conical insert before the pipetting needle itself can touch the shutter. Pressing the release sleeve pushes the release tabs outward and bends the tabs of the conical insert apart. This creates a tip at the top Opening through which the end of the needle can be immersed in the reagent solution on further introduction of the pipette.
  • the pipetting needle is pulled out of the vessel again, the end of the needle not touching the closure according to the invention, since the triggering sleeve keeps the lobes of the conical insert apart until the pipetting needle leaves the interior of the reagent container. Then the flaps close again and the conical insert closes the container tightly.
  • the trigger sleeve must be so long that during the immersion of the pipetting needle in the reagent, the trigger bars pressed apart so that the pipetting needle does not touch the closure, more precisely the conical use of the closure.
  • the release sleeve may for example consist of plastic, metal, ceramic or glass. It must not slip along the pipetting needle during the pipetting process, especially on contact with the trigger bar. Therefore, the release sleeve is preferably pinned, fixed with brackets or particularly preferably glued or incorporated directly into the needle.
  • the distance of the release sleeve to the end of the pipetting needle is determined by the depth of the conical insert and the position of the trigger bar.
  • the release sleeve must provide for the deployment of the pipette for the unfolding of the flaps of the conical insert before the end of the pipetting needle reaches the tip of the cone.
  • it When handling, it must be ensured that the pipette is not immersed so far in the sample solution that the triggering sleeve also comes into contact with the liquid. In pipetting this is usually not a problem, since the time of immersion in the liquid is determined by induction measurement and the needle is then not introduced much deeper.
  • the pipetting needle when using a closure according to the invention in combination with a pipetting needle with triggering sleeve, the pipetting needle does not touch the closure of the reagent container at any time during the sampling. There may be no reagent deposits on the closure, so that possible contamination of the contents of the vessel, e.g. by falling back on dried-on reagent residues is avoided.
  • the individual flaps of the conical insert must close tightly again after the sample has been taken.
  • This can e.g. be supported by the conical insert on the side facing the interior of the vessel with pressure springs, elastic bands or a strand-shaped, elastic membrane, which has an opening at the top, is provided.
  • the conical insert should be made of a material that is not too brittle to close again after unfolding the cloth.
  • the material should be stable enough so that the lobes are far enough apart when inserting the pipette, especially in the area of the tip.
  • this may be achieved by the use of multiple layers of material, e.g. an elastic and tight closing layer to the vessel interior and a more stable, harder outer layer can be realized.
  • the walls of the conical insert may have other seals, braces or reinforcements.
  • a pipetting device for carrying out the pipetting method according to the invention therefore comprises at least one pipette (i.e., pipette, syringe or automatic pipetting device) whose pipetting needle has a triggering sleeve and a reagent container which is closed with the closure according to the invention.
  • pipette i.e., pipette, syringe or automatic pipetting device

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Closures For Containers (AREA)

Claims (4)

  1. Procédé pour l'extraction de liquides à partir de conteneurs de réactif, caractérisé par les étapes de procédé qui suivent:
    a) fourniture d'un conteneur de réactif (7) bouché par une fermeture, dans lequel la fermeture est constituée par une partie de capuchon (6) destinée à être fixée sur le conteneur de réactif (7) et par un insert conique (4), dans lequel l'insert conique (4) est incorporé dans une ouverture de la partie de capuchon (6) et comporte une paroi conique ou pyramidale qui se termine en un point dans la direction du conteneur de réactif, caractérisé en ce que la paroi conique ou pyramidale est divisée selon des volets par au moins une découpe et comporte, sur le côté dirigé dans le sens de l'éloignement par rapport au conteneur de réactif, une nervure d'actionnement (3), laquelle est formée par une protubérance de la paroi ou par une perle fixée à la paroi, dans lequel ladite au moins une découpe dans la paroi s'étend au-delà de la nervure d'actionnement, et par une pipette dont une aiguille de pipetage (1) est munie d'une gaine d'actionnement (2);
    b) insertion verticale de l'aiguille de pipetage (1) dans le centre de l'insert conique (4) de la fermeture jusqu'à ce que l'extrémité de l'aiguille de pipetage (5) soit immergée dans le liquide, les volets de l'insert conique (4) étant poussés vers l'extérieur au niveau de la nervure d'actionnement (3) par la gaine d'actionnement (2) de telle sorte que l'aiguille de pipetage (1) ne touche pas* l'insert conique (4);
    c) soutirage ou injection de liquide; et
    d) extraction verticale de la pipette, extraction pendant laquelle les volets de l'insert conique (4) se ferment de façon étanche à nouveau aussitôt que la gaine d'actionnement (2) ne pousse plus les volets vers l'extérieur.
  2. Procédé pour l'extraction de liquides à partir de conteneurs de réactif correspondant à la revendication 1, caractérisé en ce que l'insert conique (4) de la fermeture est muni, sur le côté faisant face au conteneur de réactif (7), de ressorts de pression, de bandes élastiques ou d'une membrane élastique.
  3. Dispositif de pipetage constitué par au moins un conteneur de réactif (7) bouché par une fermeture, dans lequel la fermeture est constituée par une partie de capuchon (6) destinée à être fixée sur le conteneur de réactif (7) et par un insert conique (4), dans lequel l'insert conique (4) est incorporé dans une ouverture de la partie de capuchon (6) et comporte une paroi conique ou pyramidale qui se termine en un point dans la direction du conteneur de réactif, caractérisé en ce que la paroi conique ou pyramidale est divisée selon des volets par au moins une découpe et comporte, sur le côté dirigé dans le sens de l'éloignement par rapport au conteneur de réactif, une nervure d'actionnement (3), laquelle est formée par une protubérance de la paroi ou par une perle fixée à la paroi, dans lequel ladite au moins une découpe dans la paroi s'étend au-delà de la nervure d'actionnement, et par une pipette dont une aiguille de pipetage (1) est munie d'une gaine d'actionnement (2).
  4. Dispositif de pipetage correspondant à la revendication 3, caractérisé en ce que l'insert (4) de la fermeture est muni, sur le côté faisant face au conteneur de réactif (7), de ressorts de pression, de bandes élastiques ou d'une membrane élastique.
EP02706718A 2001-02-08 2002-01-18 Systeme de fermeture pour recipient pour reactifs Expired - Lifetime EP1358011B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10105753A DE10105753C1 (de) 2001-02-08 2001-02-08 Verschluß für Reagenzbehälter
DE10105753 2001-02-08
PCT/EP2002/000463 WO2002062474A2 (fr) 2001-02-08 2002-01-18 Systeme de fermeture pour recipient pour reactifs

Publications (2)

Publication Number Publication Date
EP1358011A2 EP1358011A2 (fr) 2003-11-05
EP1358011B1 true EP1358011B1 (fr) 2008-08-06

Family

ID=7673303

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02706718A Expired - Lifetime EP1358011B1 (fr) 2001-02-08 2002-01-18 Systeme de fermeture pour recipient pour reactifs

Country Status (8)

Country Link
US (1) US7727474B2 (fr)
EP (1) EP1358011B1 (fr)
AT (1) ATE403495T1 (fr)
AU (1) AU2002240911A1 (fr)
DE (2) DE10105753C1 (fr)
ES (1) ES2309150T3 (fr)
PT (1) PT1358011E (fr)
WO (1) WO2002062474A2 (fr)

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AU2013202805B2 (en) 2013-03-14 2015-07-16 Gen-Probe Incorporated System and method for extending the capabilities of a diagnostic analyzer
CN111495447B (zh) 2015-05-01 2022-08-26 雅培制药有限公司 用于去除容器的液体内含物的设备
WO2017161058A1 (fr) * 2016-03-15 2017-09-21 Abbott Laboratories Systèmes d'enceinte de réaction et procédés et systèmes pour les utiliser
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RU2742443C1 (ru) * 2017-10-23 2021-02-05 Аптаргруп, Инк. Клапан
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JP7093188B2 (ja) * 2018-01-25 2022-06-29 シスメックス株式会社 試薬容器、試薬の吸引方法および検体測定装置
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Also Published As

Publication number Publication date
AU2002240911A1 (en) 2002-08-19
WO2002062474A2 (fr) 2002-08-15
DE10105753C1 (de) 2002-03-28
WO2002062474A3 (fr) 2002-12-05
US7727474B2 (en) 2010-06-01
PT1358011E (pt) 2008-11-12
DE50212599D1 (de) 2008-09-18
EP1358011A2 (fr) 2003-11-05
US20040067169A1 (en) 2004-04-08
ES2309150T3 (es) 2008-12-16
ATE403495T1 (de) 2008-08-15

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