WO2017203087A1 - Adapteur permettant de fermer hermétiquement des conteneurs ou des récipients - Google Patents

Adapteur permettant de fermer hermétiquement des conteneurs ou des récipients Download PDF

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Publication number
WO2017203087A1
WO2017203087A1 PCT/ES2017/070354 ES2017070354W WO2017203087A1 WO 2017203087 A1 WO2017203087 A1 WO 2017203087A1 ES 2017070354 W ES2017070354 W ES 2017070354W WO 2017203087 A1 WO2017203087 A1 WO 2017203087A1
Authority
WO
WIPO (PCT)
Prior art keywords
container
adapter
pipette
diameter
equal
Prior art date
Application number
PCT/ES2017/070354
Other languages
English (en)
Spanish (es)
Inventor
Aitor EZKERRA FERNÁNDEZ
Diana ENÉRIZ ENÉRIZ
Yaiza BELACORTU PASTOR
Miguel Ángel RONCALÉS POZA
Original Assignee
Laboratorios Alpha San Ignacio Pharma S.L. (Alphasip)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Alpha San Ignacio Pharma S.L. (Alphasip) filed Critical Laboratorios Alpha San Ignacio Pharma S.L. (Alphasip)
Publication of WO2017203087A1 publication Critical patent/WO2017203087A1/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/56—Labware specially adapted for transferring fluids
    • B01L3/563—Joints or fittings ; Separable fluid transfer means to transfer fluids between at least two containers, e.g. connectors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/56—Labware specially adapted for transferring fluids
    • B01L3/565—Seals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/023—Adapting objects or devices to another adapted for different sizes of tubes, tips or container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs

Definitions

  • the present invention specifically relates to utensils or devices normally used in biological or chemical protocols.
  • an adapter for closing containers or containers such as tubes, vials, wells, bottles, cartridges, cameras or channels and with a form compatible with automatic and manual liquid management equipment (mainly pipettes or dispensers) , used in a variety of biological, medical or chemical protocols.
  • Biological and chemical protocols often use containers or containers to contain reagents or products of a reaction. During such protocols, it is common for the containers to remain initially open to introduce the reagents. However, it is essential to be able to close the containers tightly when necessary, since the content can be highly sensitive, dangerous, contaminating and / or volatile. Sometimes the reaction conditions can promote evaporation, causing contamination problems, loss of reagents and / or incorrect results.
  • reagent introduction protocols be carried out with a pipette or other means of automatic liquid management, in order to preserve cleanliness, reduce human error or maintain a constant process rhythm.
  • this reagent addition process is performed with a pipette or other means of manual liquid management, in order to avoid contact with hands or gloves, while preserving cleanliness.
  • closures must that the user place them on the container and exert the closure by applying manual force directly, either by insertion, compression or torsion. Therefore, these closures are not adapted so that the force is exerted by the end of the pipette or other means of dispensing liquids. Likewise, said closures are not adapted to be hooked and transported. by these same means, increasing the complexity of the necessary processes or automatisms.
  • the present invention solves the problems raised in the preceding paragraph, since it provides an adapter for closing said containers with a form compatible with automatic and manual liquid management equipment (mainly pipettes or dispensers), used in a variety of biological, medical or chemical protocols.
  • the adapter has a suspension part (2) (see figures for numerical references of the parts of the adapter) with a cavity (1) compatible with the geometry of the head of the pipette or dispenser, so that it can fit into the same to be transported to the container.
  • the adapter can be pushed against the opening of the container, using the pipette, so that the lower part of the closure (3) is inserted into the container and exerts, due to its geometry, a tight seal.
  • the adapter tightly fitted in the container can be separated from the end of the pipette by the means typically used by these systems, such as ejectors, plungers, overpressure or other direct drive means on the adapter. Subsequently, it is possible to re-fit the end of the pipette into the adapter to transport the adapter / container assembly to the desired area, hooked to the end of the pipette.
  • FIG. 1 3D image of the adapter object of the invention, showing the upper part (2) comprising a cavity (1) adapted for the introduction of the pipette end (4) and the lower part, with or without cavity, (3) adapted to the container to close it tightly.
  • FIG 2- Pipette end, (a) with the ejector retracted to show the relief where (5) the upper part of the adapter fits; (b) with the ejector displaced in the position of separation of the adapter.
  • Figure 3- Image of the adapter and container assembly fitted and attached to the end of the pipette. The pipette end is shown in (6), the adapter object of the present invention in (7) and the container in (8). Once separated, the adapter / container assembly has a tight seal.
  • Figure 4- is
  • the device object of this invention is an adapter for the sealing of containers or containers. Due to its shape, said adapter can only be manipulated by means of automatic or manual liquid management devices, such as pipettes or dispensers. Such manipulation includes the fitting of the upper part of the adapter to the end of the pipette, its transport to the container, the fitting of the lower part of the adapter in the container for sealing and the release of the upper part of the end adapter. of the pipette. Additionally, it is also possible to transport the adapter / container assembly to the desired area once the seal is made.
  • the main objective of the adapter is to provide a tight seal that prevents evaporation of the reagents contained in the container, preferably, when it is subjected to temperature increases (which may be close to that of boiling, for example, during amplification protocols of nucleic acids).
  • the adapter consists of a single piece, not requiring the use of any other device or part to achieve closure. From the point of view of functionality, two parts can be distinguished: - An upper part with a cavity, through which the end of the pipette is introduced and whose geometry allows adjusting the adapter and, therefore, allows its transport to the container.
  • Said geometry may vary to adapt to different types of containers, closing them in some of the following ways or combination thereof:
  • the geometry of the adapter is ideal for transport, since the diameter of the cavity of the upper part is equal to or slightly smaller than the end of the pipette, preventing the adapter from detaching by gravity.
  • the adapter is shown in Figure 1.
  • a first aspect of the invention relates to an adapter for the sealing of containers or containers consisting of a single piece characterized in that it comprises: a.
  • the upper part of the adapter (2) contains an open cavity (1) where the end of a manual or automatic pipette (4) is inserted.
  • the objective of this cavity is, therefore, the introduction of the end of the pipette so that this end fits into the cavity (1) allowing the adapter to be transported in the pipette (see figures 3 and 4).
  • said cavity must have a complementary geometry or a diameter equal to or slightly smaller than the end of the pipette, preventing the adapter from detaching from the pipette during transport.
  • the containers or containers object of this invention mainly tubes, vials, wells, bottles, cartridges, chambers and channels
  • said cavity will have a diameter between 0 , 5mm and 10mm, or preferably between 5mm and 6mm or between 4mm and 7mm or between 0.5mm and 3mm.
  • pipette end means the free end of a pipette or other means of automatic or manual liquid management, which contains the suction and liquid dispensing orifice.
  • the term “prevent the adapter from detaching” is understood as preventing the adapter from separating from the end of the pipette by gravity, rather than by the active means typically used by these systems, such as pushbuttons, plungers, overpressure or other direct drive means on the adapter.
  • the diameter of the cavity (1) of the upper part of the adapter (2) must have a complementary geometry or a diameter equal to or slightly less than that of the point of contact with the end of the pipette, which is between 0, 5mm and 10mm, or preferably between 5mm and 6mm or between 4mm and 7mm or between 0.5mm and 3mm.
  • the adapter of the first aspect of the invention comprises a lower part (3) as shown in Figure 1. Said lower part must allow the container or container to be closed tightly using the pipette or liquid management means attached to the upper part (2) of the adapter. To do this, the closure or adapter can fit and seal the container or container in various ways as explained above. In either case, once the adapter has hermetically closed the container or container, the pipette or liquid management means has to eject the adapter by the active means typically used by these systems, such as ejectors, plungers, overpressure or other means of direct drive on the adapter.
  • hermetic closure means that the adapter, once inserted into the container and after separating from the end of the pipette or the liquid management medium, exerts a closure that does not allow the passage of gases or liquids between inside and outside (and vice versa).
  • the lower part (3) is introduced into the container or container by exerting pressure on the inner walls of the container or container so that a tight seal of said container or container is produced.
  • the lower part (3) has a solid or hollow section, with thicknesses between 0.1 mm and 3 mm, or preferably between 0.1 mm and 0.6 mm, between 0.1 mm and 0.4 mm or between 1 mm and 3 mm, which is adjusted to the container by means of a straight or conical profile with a diameter equal to or greater than that of the container and between 0.1 mm and 20 mm, preferably between 4 mm and 6 mm, between 4 mm and 10 mm, between 0.1 mm and 10mm or between 10mm and 20mm.
  • the penetration depth in the container varies between 0.1 mm and 30 mm or preferably between 7.5 mm and 10 mm, between 4 mm and 7.5 mm, between 4 mm and 10 mm, between 10 mm and 30 mm or between 0.1 mm and 4 mm.
  • the length of the lower part varies between 0.1 mm and 30 mm or preferably between 8 mm and 10 mm, between 8 mm and 30 mm, between 4 mm and 8 mm or between 0.1 mm and 4 mm.
  • the lower part (3) covers the outer edges and walls of the container or container by exerting pressure on said walls so that a tight seal of said container or container is produced.
  • the lower part (3) has a hollow section with thicknesses between 0.1 mm and 3 mm or preferably between 0.1 mm and 0.4 mm, between 0.1 mm and 0.6 mm or between 1 mm and 3mm, which covers the container in its outer part by means of an opening with a straight or conical profile, of a diameter equal to or less than that of the container and between 0.1 mm and 20mm or preferably between 4mm and 6mm, between 4mm and 10mm, between 0 , 1mm and 10mm or between 10mm and 20mm.
  • the length of the adapter covering the outer part of the container varies between 0.1 mm and 30 mm or preferably between 0.75 mm and 10 mm, between 0.4 mm and 0.75 mm or between 0.1 mm and 4 mm.
  • the length of the lower part (3) varies between 0.1 mm and 30 mm or preferably between 8 mm and 10 mm, between 8 mm and 30 mm, between 4 mm and 8 mm or between 0.1 mm and 4 mm.
  • the lower part (3) covers the outer and inner edges and walls of the container or container by exerting pressure on said walls so that a tight seal of said container or container is produced.
  • the lower part (3) has a hollow section with thicknesses between 0.1 mm and 3 mm or preferably between 0.1 mm and 0.4 mm, between 0.1 mm and 0.6 mm or between 1 mm and 3mm, which covers the container in its external part through an opening with a straight or conical profile, of a diameter equal to or less than that of the container and between 0.1 mm and 20mm or preferably between 4mm and 6mm, between 4mm and 10mm, between 0 , 1mm and 10mm or between 10mm and 20mm.
  • the length of the adapter covering the outer part of the container varies between 0.1 mm and 30 mm or preferably between 0.75 mm and 10 mm, between 0.4 mm and 0.75 mm or between 0.1 mm and 4 mm.
  • the lower part of the adapter (3) also has a solid or hollow section, with thicknesses between 0.1 mm and 3 mm or preferably between 0.1 mm and 0.4 mm, between 0.1 mm and 0.6mm or between 1mm and 3mm, which fits inside the container by means of a straight or conical profile with a diameter equal to or greater than that of the container and between 0.1mm and 20mm or preferably between 4mm and 6mm , between 4mm and 10mm, between 0.1mm and 10mm or between 10mm and 20mm.
  • the penetration depth in the container varies between 0.1 mm and 30 mm or preferably between 7.5 mm and 10 mm, between 4 mm and 7.5 mm, between 4 mm and 10 mm, between 10 mm and 30 mm or between 0.1 mm and 4 mm.
  • the adapter is characterized in that: to.
  • the open cavity (1) has a diameter between 0.5mm and 10mm, being equal to or slightly smaller than the diameter of the pipette end at the point of contact, located at a depth between 0.1mm and 30mm.
  • the section of said cavity can be straight or conical and have a length between 0.1 mm and 30 mm.
  • the lower part (3) has a solid or hollow section, with thicknesses between
  • the adapter is characterized in that: a.
  • the open cavity (1) has a diameter between 0.5mm and 10mm, being equal to or slightly smaller than the diameter of the pipette end at the point of contact, located at a depth between 0.1mm and 30mm.
  • the section of said cavity can be straight or conical and have a length between 0.1 mm and 30 mm.
  • the lower part (3) has a hollow section with thicknesses between 0.1 mm and
  • the adapter is characterized in that: a.
  • the open cavity (1) has a diameter between 0.5mm and 10mm, being equal to or slightly smaller than the diameter of the pipette end at the point of contact, located at a depth between 0.1mm and 30mm.
  • the section of said cavity can be straight or conical and have a length between 0.1 mm and 30 mm.
  • the lower part (3) has a hollow section with thicknesses between 0.1 mm and
  • the lower part of the adapter (3) also has a solid or hollow section, with thicknesses between 0.1 mm and 3 mm, which fits the container in its internal part by means of a straight profile or conical diameter equal to or greater than that of the container and between 0.1 mm and 20 mm.
  • the depth of penetration into the container varies between 0.1 mm and 30 mm.
  • the length of the lower part (3) varies between 0.1 mm and 30 mm.
  • the upper part (2) of the adapter comprises the following dimensions: A depth of 0.5mm to 20mm, a diameter (external) of 0.6mm to 30mm and a thickness of 0.1mm to 3mm.
  • the material used for the preparation of the adapter must avoid contamination by external agents, leaks or spills of the container or container as well as avoid evaporation of the contents of said container during transport, use or storage.
  • the material used must be non-porous, preferably a thermoplastic, more preferably a material selected from the list consisting of Polypropylene (PP), Polystyrene (PS), Acrylonitrile Butadiene Styrene (ABS), Polyvinylchloride Vinyl (PVC), Polyether ketone (PEEK), Cyclic olefin polymers (COP), Cyclic olefin co-polymers (COC), Polyethylene (PE), Polyethylene terephthalate (PET), Polycarbonate (PC), High density polyethylene (HDPE), Polymethylmethaclate (PMMA), Low Density Polyethylene (LDPE), Polyamides, Polytetrafluorotylene (PTFE), and Polyimides.
  • PP Polypropylene
  • PS Polystyren
  • thermoplastic used would preferably be Polypropylene (PP), Polystyrene (PS), Polyvinylchloride (PVC), High Polyethylene density (HDPE), Low Density Polyethylene (LDPE), Polyethylene (PE), Cyclic Olefin Polymers (COP) or Cyclic Olefin Co-Polymers (COC). It is important to highlight that the main condition is that the material is little or not porous in order to prevent the pores from retaining the contents of the container or that the vapors escape through them aided by overpressure.
  • PP Polypropylene
  • PS Polystyrene
  • PVC Polyvinylchloride
  • HDPE High Polyethylene density
  • LDPE Low Density Polyethylene
  • PE Polyethylene
  • COP Cyclic Olefin Polymers
  • COC Cyclic Olefin Co-Polymers
  • a second aspect of the invention refers to the use of the adapter as defined in the first aspect of the invention or in any of its embodiments. preferred, for the tight closing of containers or containers by means of a liquid or reagent dispensing system. Preferably, by the action of a manual or automatic pipette.
  • the adapter is characterized in that: a.
  • the open cavity (1) has conical geometry throughout its length. At a depth of 3mm its diameter is 5mm, this dimension being slightly smaller than the diameter of the pipette end at the contact points.
  • the section of said cavity has a length of 11 mm.
  • the thickness of said cavity is 0.6mm, providing the necessary stiffness at the point of contact to allow said cavity to be inserted into the end of the pipette, in this case automatic, without being able to detach by gravity.
  • the lower part (3) has a hollow section, with a thickness of 0.4mm, which fits inside the container thanks to the conical profile it incorporates and a raised area.
  • the dimension of both the conical profile and the relief is greater than the dimension of the conical profile that incorporates the container in that area.
  • the container in the upper area, where the contact area between the adapter and the container takes place has a conical profile between 5.4mm and 6.4mm.
  • the depth of penetration of the adapter into the container is 7.5mm.
  • the length of the bottom part (3) is 8mm.
  • the example adapter is adapted to a container that can accommodate a total volume of 330 ⁇ alber and in which the reaction volume can range between 0.2 ⁇ and 127 ⁇ .
  • the manufacturing material of this adapter for this specific application is PP.

Abstract

La présente invention concerne un adaptateur permettant de fermer des récipients présentant une forme compatible avec les équipements automatiques et manuels de gestion de liquides (principalement des pipettes ou des distributeurs) utilisés dans divers protocoles biologiques, médicaux ou chimiques. Ledit adaptateur comprend une pièce unique et il n'est pas nécessaire d'utiliser un autre dispositif ou une autre pièce pour réussir à réaliser la fermeture. D'un point de vue fonctionnel, on peut distinguer deux parties : - une partie supérieure présentant une cavité, par laquelle est introduite l'extrémité de la pipette et dont la géométrie permet d'ajuster l'adaptateur et, par conséquent, permet de le transporter jusqu'au récipient ; et - une partie inférieure présentant une cavité ou non, qui est introduite dans le récipient et réalise, grâce à sa géométrie, une fermeture hermétique.
PCT/ES2017/070354 2016-05-25 2017-05-25 Adapteur permettant de fermer hermétiquement des conteneurs ou des récipients WO2017203087A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16382231 2016-05-25
EP16382231.5 2016-05-25

Publications (1)

Publication Number Publication Date
WO2017203087A1 true WO2017203087A1 (fr) 2017-11-30

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Application Number Title Priority Date Filing Date
PCT/ES2017/070354 WO2017203087A1 (fr) 2016-05-25 2017-05-25 Adapteur permettant de fermer hermétiquement des conteneurs ou des récipients

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WO (1) WO2017203087A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115485072A (zh) * 2021-04-16 2022-12-16 Apc包装有限责任公司 滴管

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1183104A2 (fr) * 1999-05-14 2002-03-06 Gen-Probe Incorporated Capuchon pouvant etre perce et appareil de transfert de liquide utilisable avec ledit capuchon
US20040067169A1 (en) * 2001-02-08 2004-04-08 Reinhard Krause Closure for a reagent container
US20130234432A1 (en) * 2012-03-12 2013-09-12 Idex Health & Science Llc Microfluidic Interconnect
WO2015166134A1 (fr) * 2014-04-28 2015-11-05 Thermo Fisher Scientific Oy Bouchon de flacon de réactif, système, procédé et appareil pour manipuler des bouchons de fermeture et similaire
US20150337400A1 (en) * 2010-07-23 2015-11-26 Beckman Coulter, Inc. System and method for controlling thermal cycler modules

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1183104A2 (fr) * 1999-05-14 2002-03-06 Gen-Probe Incorporated Capuchon pouvant etre perce et appareil de transfert de liquide utilisable avec ledit capuchon
US20040067169A1 (en) * 2001-02-08 2004-04-08 Reinhard Krause Closure for a reagent container
US20150337400A1 (en) * 2010-07-23 2015-11-26 Beckman Coulter, Inc. System and method for controlling thermal cycler modules
US20130234432A1 (en) * 2012-03-12 2013-09-12 Idex Health & Science Llc Microfluidic Interconnect
WO2015166134A1 (fr) * 2014-04-28 2015-11-05 Thermo Fisher Scientific Oy Bouchon de flacon de réactif, système, procédé et appareil pour manipuler des bouchons de fermeture et similaire

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115485072A (zh) * 2021-04-16 2022-12-16 Apc包装有限责任公司 滴管

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