EP1351768A2 - Dispositif d'examen - Google Patents

Dispositif d'examen

Info

Publication number
EP1351768A2
EP1351768A2 EP02703557A EP02703557A EP1351768A2 EP 1351768 A2 EP1351768 A2 EP 1351768A2 EP 02703557 A EP02703557 A EP 02703557A EP 02703557 A EP02703557 A EP 02703557A EP 1351768 A2 EP1351768 A2 EP 1351768A2
Authority
EP
European Patent Office
Prior art keywords
receiving
support
elements
examination device
bottom side
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02703557A
Other languages
German (de)
English (en)
Inventor
Olaf Sollboehmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evotec OAI AG
Original Assignee
Evotec OAI AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evotec OAI AG filed Critical Evotec OAI AG
Publication of EP1351768A2 publication Critical patent/EP1351768A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/50—Clamping means, tongs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates

Definitions

  • the invention relates to an examination device for examining chemical and / or biological samples.
  • the invention further relates to a sample carrier that can be inserted into the examination device.
  • Such examination devices are, for example, devices for carrying out screening processes (high throughput screening).
  • Small sample quantities are fed to sample carriers so that one sample carrier has a large number of samples.
  • the individual samples are examined in succession, for example, in an automated process with the aid of microscopes or other examination devices. Since in modern sample carriers the sample quantities are very small and the distances between the individual samples are very small, it is necessary that the position of the sample carrier in the examination device is precisely defined. This is also of great importance because it involves continuous examination methods in which, for example, the sample carrier is moved relative to the microscope. It must be ensured that the sample is arranged exactly in the beam path of the microscope.
  • the centering of the sample carrier with the aid of a receiving device designed as a frame has the disadvantage that sample carriers produced in the plastic injection molding process cannot be injection molded onto the outside.
  • a sprue is created, which leads to an unevenness in the outer edge. These bumps can result in the sample holder not being able to be inserted in the correct position in the frame or jammed in it.
  • a frame-shaped receiving device Another disadvantage of a frame-shaped receiving device is that the sample carriers are exposed to thermal influences during the examination. Due to the thermal influences, expansion can occur in the sample carriers. This leads to jamming of the sample holder in the frame.
  • the sample carrier can be, for example, a titer plate. These usually have a carrier plate in which recesses arranged in a matrix are provided. An automated process, for example, is used to fill a sample into the recesses. These samples are then automatically examined. In particular, the samples received in the recesses are very small samples with a volume of less than 1 ml. In modern methods, titer plates are used in which sample amounts in the microliter or submicroliter range can be examined.
  • the sample carriers can be chips.
  • Chips usually have one or more channels and possibly one or more Liquid reservoirs. For example, if it is a microfluidic chip with preferably two reservoirs that are connected to one another via a channel, properties of the fluid exchange can be examined.
  • the object of the invention is to provide an examination device for examining chemical and / or biological samples into which a sample carrier can be easily inserted with a good position fixation. Furthermore, it is an object of the invention to provide a sample carrier which, with a good position fixation, can easily be inserted into an examination device.
  • the examination device has a receiving device and a sample carrier.
  • the sample holder can be inserted into the receiving device.
  • the sample carrier has a carrier plate with a receiving side, via which the samples are fed, and a bottom side opposite the receiving side. If the sample carrier is, for example, a titer plate, the receiving side is the one on which the individual wells are open, so that samples can be filled into the wells via the openings.
  • the carrier plate has support elements on its bottom side for fixing the position in the receiving device.
  • the support elements are thus arranged directly on the bottom side and / or the underside of the carrier plate.
  • the receiving device of the examination device has receiving elements corresponding to the support elements of the carrier plate.
  • the sample carrier can thus be placed on the receiving elements of the receiving device in a simple manner from above. It is only necessary to ensure that a support element of the carrier plate a corresponding receiving element of the receiving device is arranged opposite each other.
  • the support or receiving elements can be designed such that the floor support is self-adjusted in the receiving device. This has the advantage that the support elements do not have to be arranged exactly opposite the receiving elements when the sample carrier is inserted into the receiving device.
  • the provision of support elements on the bottom side of the carrier plate has the advantage that the carrier plate can be inserted more easily into the receiving device. Furthermore, the sample carrier can expand due to thermal influences without jamming in a holder, such as a frame. Since the outer edge of the sample holder is not required to fix the position, it is possible to inject the sample holder from the outside over the edge. This simplifies manufacturing and reduces manufacturing costs.
  • the support elements are preferably designed such that the carrier plate is automatically aligned in the receiving device with respect to its two horizontal degrees of freedom when it is inserted into the receiving device. This has the advantage that slight horizontal displacements between the support elements and the receiving elements do not cause any disturbances when the sample carrier is inserted into the receiving device.
  • At least two support elements can be provided, for example.
  • One of the two support elements preferably has a spherical surface which engages in a receiving element of the receiving device designed as a conical shell.
  • This pair of elements prevents the plate from moving in the horizontal direction.
  • the plate can only be rotated around a vertical axis running through the center of the sphere.
  • the second pair of elements as Support element, for example, to provide a V-shaped channel into which, for example, a pin with a spherical end is inserted as a receiving element. Since the combination of a pair of elements is relevant in each case, it is irrelevant which of the two mutually corresponding elements is provided on the carrier plate and which is provided on the receiving device.
  • Another possibility for automatically aligning the sample carrier with respect to the two horizontal degrees of freedom is to provide two pairs of elements, each consisting of a V-shaped or prismatic groove and a pin with a spherical end or rounded tip.
  • the longitudinal directions of the two grooves must form an angle with one another. Moving the sample carrier would only be possible if the two pairs of elements are aligned parallel to each other.
  • the carrier plate has three support elements.
  • two of the three support elements and the corresponding receiving elements can be designed as described above in order to ensure automatic alignment of the sample carrier with respect to the two horizontal degrees of freedom.
  • the third pair of elements then serves to implement a three-point support of the sample holder. Tilting of the sample carrier is thus avoided by means of the third pair of elements, so that the sample carrier is aligned essentially horizontally by the third pair of supports.
  • at least two support elements and / or receiving elements can preferably be adjusted in a direction perpendicular to the base plate.
  • the sample holder can always be aligned horizontally when it rests on three points.
  • the third pair of elements is, for example, both the support element and the receiving element a surface oriented parallel to the bottom side.
  • a flat surface and a pointed pen can be provided as a pair of elements in order to be able to achieve a better horizontal alignment of the sample carrier.
  • the tip of the pin is preferably rounded, so that a pin with a spherical end is formed.
  • the invention further relates to a sample carrier which is designed as described above.
  • a sample carrier is suitable for being picked up by a correspondingly adapted recording device of an examination device.
  • the insertion of such a sample carrier into a receiving device is considerably easier than with known sample carriers.
  • FIG. 1 is a schematic view of a first embodiment of a sample carrier according to the invention from below,
  • Fig. 2 is a schematic side view of that shown in Fig. 1
  • FIGS. 3-5 different embodiments of support elements corresponding to receiving elements
  • Fig. 6 is a schematic view of a second embodiment of the sample holder according to the invention from below and Fig. 7 is a schematic side view of that shown in Fig. 6
  • the embodiment shown is a titer plate with a carrier plate 10.
  • the carrier plate 10 has recesses 12 for receiving chemical and / or biological samples.
  • the depressions 12 extend from a receiving side 14 through the carrier plate 10.
  • the depressions 12 are closed on a side opposite the receiving side 14 with a base part 16, in particular a thin glass plate. It is thus possible to carry out measurements or examinations in the sample located in the recesses 12 from below through the transparent base plate 16.
  • the support plate 10 To receive the base plate 16, the support plate 10 has a frame-shaped extension 18 which serves to center the base plate 16. In the case of conventional titer plates, these are placed in the examination device on a bottom side 20 of the frame-shaped attachment opposite the receiving side.
  • support elements 22, 24, 26 are provided on the bottom side.
  • the support element 24 is a hemispherical support element. This engages in a corresponding receiving element (Fig. 3).
  • the receiving element 28 is a conical shell. Due to the spherical support element 24, which corresponds to the conical shell 28, the sample holder can only be rotated about an axis 30 running perpendicular to the bottom side 20 and running through the center of the spherical support element. Between the hemispherical support element 34 and the conical receiving element 28 there is line contact along a circular line.
  • the support element 26 is an extension with a prismatic groove. This is a support element which has at least one support surface 32 which is arranged obliquely to the bottom side 20.
  • the support element 26 corresponds to a pin-shaped receiving element 34 with a spherical end, which is provided corresponding to the conical shell 28 on the receiving device of the examination device. In the pair of elements shown in Fig. 4, only a shift in the longitudinal direction of the groove 26, i.e. perpendicular to the plane of the drawing.
  • the support element 22 is arranged as a third support element on the bottom side of the frame-shaped extension 18 of the support plate.
  • This is a support element having a flat surface 40 (FIG. 5).
  • a pin 42 with a hemispherical end can be provided, for example, as the receiving element of the receiving device of the examination device corresponding to the support element 22.
  • two of the three receiving elements 28, 34, 42 can be displaced in the Z direction. Since the carrier plate is used in an automatic examination method, the receiving elements are adjusted, for example, by an electric motor drive.
  • second embodiment of the invention is also a carrier plate 10 with recesses 12 which are closed by a base plate 16 preferably designed as a glass plate.
  • the carrier plate 10 also has a frame-shaped extension 18.
  • a receiving side 14 is provided on the side of the openings of the recesses, which is opposite a bottom side 20.
  • the second embodiment differs from that in FIGS. 1 and 2 shown first embodiment in the type and arrangement of the support elements 46,48,50.
  • the three support elements 46, 48, 50 are each designed as V-shaped grooves or V-shaped grooves.
  • Each of the V-shaped grooves has two contact surfaces 52.
  • the contact surfaces are at an angle, i.e. arranged obliquely to the bottom side 20.
  • the grooves can also be prismatic.
  • Receiving elements are each designed as pins with a hemispherical end.
  • the three pairs of elements thus correspond to the combination of a support element 26 and a receiving element 34 shown in FIG. 4. Since only the combination of receiving and support element is important, their arrangement can also be interchanged. The type of arrangement can also be used as a guide.
  • the three support elements 46, 48, 50 are arranged in a star shape. This means that two of the center lines 54, 56, 58 in The three angles formed between these three lines 54, 56, 58 are preferably identical.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

L'invention concerne un dispositif d'examen comprenant un dispositif de réception et un support pour échantillon, qui peut être placé dans le dispositif de réception. Ce support pour échantillon est constitué d'une plaque support (10) sur laquelle sont placés des échantillons chimiques et/ou biologiques. La plaque support (10) comporte une face réceptrice (14), sur laquelle sont amenés les échantillons, et un fond (20) opposé à la face réceptrice (14). Ce fond (20) de plaque support (10) comprend des éléments d'appui (22,24,26) pour sa fixation dans le dispositif de réception du dispositif d'examen. Le dispositif de réception est doté d'éléments de réception (28,34,42) correspondant aux éléments d'appui (22,24,26).
EP02703557A 2001-01-20 2002-01-17 Dispositif d'examen Withdrawn EP1351768A2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE20101080U 2001-01-20
DE20101080U DE20101080U1 (de) 2001-01-20 2001-01-20 Untersuchungsvorrichtung
PCT/EP2002/000422 WO2002062477A2 (fr) 2001-01-20 2002-01-17 Dispositif d'examen

Publications (1)

Publication Number Publication Date
EP1351768A2 true EP1351768A2 (fr) 2003-10-15

Family

ID=7951916

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02703557A Withdrawn EP1351768A2 (fr) 2001-01-20 2002-01-17 Dispositif d'examen

Country Status (4)

Country Link
EP (1) EP1351768A2 (fr)
AU (1) AU2002237276A1 (fr)
DE (1) DE20101080U1 (fr)
WO (1) WO2002062477A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112317000A (zh) * 2020-10-31 2021-02-05 济南骄峰智能设备有限公司 一种插板式组合烧杯托架

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8066961B2 (en) 2005-07-20 2011-11-29 Corning Incorporated Kinematic wellplate mounting method
WO2007018872A1 (fr) 2005-07-20 2007-02-15 Corning Incorporated Système et procédé de criblage biomoléculaire de rendement élevé sans étiquetteod
CA2789946C (fr) * 2010-02-22 2017-12-12 Perkinelmer Health Sciences, Inc. Systeme de fixation de microplaque et procedes de detection

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US3907505A (en) * 1973-05-30 1975-09-23 Miles Lab Selectively detachable apparatus
US3938958A (en) * 1975-03-24 1976-02-17 Corning Glass Works Fluid dispensing device
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ATE30962T1 (de) * 1983-01-15 1987-12-15 Hoechst Ag Probensammler.
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WO1991017460A1 (fr) * 1990-05-08 1991-11-14 Wallac Oy Compteur de scintillations d'echantillons liquides
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US5759494A (en) * 1995-10-05 1998-06-02 Corning Incorporated Microplates which prevent optical cross-talk between wells
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112317000A (zh) * 2020-10-31 2021-02-05 济南骄峰智能设备有限公司 一种插板式组合烧杯托架

Also Published As

Publication number Publication date
AU2002237276A1 (en) 2002-08-19
WO2002062477A3 (fr) 2002-11-14
DE20101080U1 (de) 2002-06-06
WO2002062477A2 (fr) 2002-08-15

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