EP1351662A1 - Cosmetic and/or pharmaceutical preparations - Google Patents
Cosmetic and/or pharmaceutical preparationsInfo
- Publication number
- EP1351662A1 EP1351662A1 EP02703537A EP02703537A EP1351662A1 EP 1351662 A1 EP1351662 A1 EP 1351662A1 EP 02703537 A EP02703537 A EP 02703537A EP 02703537 A EP02703537 A EP 02703537A EP 1351662 A1 EP1351662 A1 EP 1351662A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- sep
- extracts
- acid
- preparations
- contain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 239000000825 pharmaceutical preparation Substances 0.000 title claims abstract description 13
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- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 claims description 18
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- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 11
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Abstract
Description
Kosmetische und/oder pharmazeutische Zubereitungen Gebiet der Erfindung Die Erfindung befindet sich auf dem Gebiet der Kosmetik und betrifft Zubereitungen mit einem wirksamen Gehalt an Extrakten von Wiederauferstehungspflanzen sowie die Verwendung der Extrakte sowie der darin enthaltenen Wirkstoffe zur Herstellung der Mittel.
Stand der Technik Ein wesentlicher Grund für die Hautalterung besteht im Wasserverlust in den oberen Schichten der Epidermis und der damit verbundenen Faltenbildung. Demzufolge besteht einer der Ansätze, mit dem Kosmetikchemiker diesem Phänomen begegnen wollen, solche Wirkstoffe zur Verfügung zu stellen, die dem Umweltstress sowie der Entwässerung entgegenwirken und/oder eine Schutzfunktion besitzen, so dass die Zellen bei ihrem andauernden Kampf gegen Umweltgifte gestärkt werden. Dazu ist es erforderlich, mitunter ausgefallene Lösungswege zu beschreiten. So kann es angezeigt sein, aus den Erkenntnissen, die die Natur uns liefert wichtige Informationen zu entnehmen und für die jeweiligen Bedürfnisse zu übertragen.
In den Wüstengebieten und Trockenzonen Afrikas, Asiens und Amerikas haben eine Reihe von Pflanzenfamilien eine bemerkenswerte Trockentoleranz entwickelt, die es ihnen erlaubt, auch eine 98% ige Dehydratisierung über einen Zeitraum von einem Jahr unbeschadet zu überstehen, um sich dann bei den ersten Monsunregenfällen innerhalb von 24 h wieder vollständig zu regenerieren und Blüten zu bilden. Diese poikilohydrischen Vertreter werden unter der Bezeichnung"Wiederauferstehungspflanzen"oder Resurrection plants"zusammenge- fasst. Hierzu zählen sowohl Moose, Flechten und Farne als auch eine Reihe von blühenden Pflanzen (Angiospermien), bei deren Untersuchung man gefunden hat, dass die anatomi sche, biochemische und physiologische Adaptation durch das Genom bedingt wird.
Die Pflanzen werden während der Trockenphase zwei unterschiedlichen Belastungen ausgesetzt, nämlich zum einen mechanischem und zum anderen oxidativem Stress. Um mechanischer Belastung auszuweichen, haben Wiederauferstehungspflanzen eine Palette von Möglichkeiten, von denen das Schrumpfen und Teilen von Vakuolen zur Erniedrigung der Span nung auf der Plasmamembran allgemein verbreitet ist. Weitere Effekte sind der verstärkte Einbau von Xyloglucanen und Methylestern des Pectins in die Zellwand sowie die Akkumulation von Osmolyten oder osmo-regulierenden Molekülen (z. B. Sucrose, Mannitol, D-Ononitol, Trehalosen, Fructane, Aminosäuren etc.), wodurch die Zellwand gestärkt und die Produktion von toxischen Metaboliten während der Entwässerung unterbunden wird.
Die Unterbrechung von Zellatmung und Photosynthese während der Trockenphase führt des weiteren zur Bildung von freien Radikalen, die Proteine, Fette und Nucleinsäuren schädigen können. Um dies zu verhindern, werden in den Zellen vermehrt Pigmente vom Anthocyantyp sowie spezielle Enzyme angetroffen, wie z. B. Superoxid Dismutase, Gluthation Reduktase oder Ascorbat Peroxydase, die in den oxidativen Metabolismus eingreifen und als natürliche Radikalfänger bekannt sind.
Die molekularen Grundlagen der Trockentoleranz sind bislang noch nicht vollständig aufgeklärt. Nach Untersuchungen von D. Bartels an der Universität Bonn scheint aber zu festzustehen, dass Pflanzenhormone, wie beispielsweise Abszisinsäure (ABA) die Trockentoleranz induzieren. In der Zwischenzeit konnten auch eine Reihe von Genen, die sowohl am Prozess der Austrocknung als auch der Wiederbewässerung beteiligt sind, isoliert werden. Dabei wurde überraschenderweise festgestellt, dass diese homolog zu Genen sind, die man auch in Embryos von heranreifenden Samen findet.
So wird beispielsweise beim Austrocknen das Gen dsp-22 (desiccation stress protein) aktiviert, welches die Bildung eines 21 KDa Protein anregt, das sich in den Chloroplasten ansammelt [vgl. D. Bartels et al. EMBO Journal 11 (8), 2771 (1992)]. Des weiteren sind Veränderungen im Zuckerstoffwechsel von Bedeutung. So finden sich beispielsweise in den Blättern nicht gestressten Pflanzen hohe Konzentrationen des ungewöhnlichen Zuckers 2-Oktulose, der während des Austrocknens in Saccharose umgewandelt wird und dabei wohl eine Schutzfunktion besitzt. Bei Wiederbewässerung ist der Vorgang reversibel.
In diesem Zusammenhang sei auch auf die internationale Patentanmeldung WO 97/42327 (University of Mexico) verwiesen, in der über die Isolierung eines Gens aus der Wiederauferstehungspflanze Selaginella lepidophylla berichtet wird, welches den Zucker Trehalose-6-phosphat produziert.
Die Aufgabe der vorliegenden Erfindung hat somit darin bestanden, neue Wirkstoffe zu entwickeln, mit denen im allgemeinen Haut und Haare vor Umwelteinflüssen geschützt werden und speziell der Austrocknung der Haut vorgebeugt werden kann. Des weiteren sollten Haut und Haaren einen zusätzlichen Schutz gegenüber osmotischem und temperaturbedingten Schock verliehen werden.
Beschreibung der Erfindung Gegenstand der Erfindung sind kosmetische und/oder pharmazeutische Zubereitungen, enthaltend Extrakte von Wiederauferstehungspflanzen ("Resurrection plants").
Überraschenderweise wurde gefunden, dass die Extrakte-welche auch als"Überlebensfrak tionen"oder"Survival fractions"bezeichnet werden-bzw. die darin enthaltenen Wirkstoffe, bei denen es sich vorwiegend um Osmolyte (Polysaccharide), Terpene, Antioxidantien und Phytohormone sowie Proteine handelt, die eingangs genannte Aufgabe hervorragend erfül- len. Die Extrakte können als solche eingesetzt werden, es ist jedoch auch möglich, einzelne Bestandteile daraus zu isolieren und dann den Erfordernissen entsprechend in anderer Zusammensetzung abzumischen.
Wiederauferstehungspflanzen Wiederauferstehungspflanzen stellen keine zusammenhängende Gruppe dar, sondern finden sich in sehr unterschiedlichen Pflanzenfamilien, von denen vor allem die Familien der Poacea, Scrophulariacea, Myrothamnacea und/oder Velloziacea zu nennen sind.
In einer besonderen Ausführungsform der Erfindungen enthalten die Zubereitungen Extrakte von Wiederauferstehungspflanzen die ausgewählt sind aus der Gruppe der botanischen Familen der Poacea, Scrophulariacea, Myrothamnacea und/oder Velloziacea, Zu den wichtigsten Vertretern der Poaceae gehört der Genus Spirobolus, beispielsweise ein Gras, das eine Höhe von 60 bis 120 cm erreicht und pinkfarbene Blüten entwickelt.
Es ist vor allem auf dem amerikanischen Kontinent, speziell in Costa Rica verbreitet, wo man die Spezies Spirobolus cubensis, Spirobolus indicus, Spirobolus heterotepsis, Spirobolus capillaris, Spirobolus flexuosus, Spirobolus cryptandrus und Spirobolus airoides antrifft. Ein besonders wichtiges Beispiel für eine Wiederauferstehungspflanze aus der Familie der Scrophulariaceae ist der Genus Craterostigma, insbesondere die Spezies Craterostigma plantigineum. Aus der Familie der Myrothamnaceae ist vor allem Myrothamnus niedenzu und Myrothamnus flabel lifolia zu nennen, insbesondere bevorzugt im Sinne der Erfindung ist die Familie der Myrothamnus flabellifolia das schon 1891 erstmals von Engler und Prantl beschrieben wurde.
Hierbei handelt es sich um einen flachen Strauch, der in den trockenen Wintermonaten seine Blätter nicht verliert, sondern eng an die Zweige anlegt und mit den ersten Sommerregen wieder zum Leben erwacht. Wesentliche Bestandteile der Extrakte seiner Blätter sind Arbutin, Anthocyane, Polysaccharide (Sucrose, Glucose, Trehalose, Fructose, Glucosyl-9-glycerin) sowie Phytohormone (z. B. Abszisinsäure) ; weiterhin werden Terpene, wie z. B. Carvone und Perillalkohol gefunden. Ähnlich wie Octulose spielt auch Arbutin eine wichtige, wenn auch andere Rolle bei der Trockenresistenz, da es als Hydrochinonquelle die Peroxidation von ungesättigten Lipiden in den Zellmembranen verhindert.
Typische Beispiele für Wiederauferste hungspflanzen aus der Familie der Vel/ozAacea sind die Vertreter des Genus Xerophyta, wie beispielsweise die in Madagaskar beheimateten Xerophyta retinervis und Xerophyta viscosa, bei denen es sich um flache Büsche handelt, die in der Monsunzeit prächtige violette Blüten entwickeln. Erfindungsgemäss ebenfalls geeignet sind Extrakte der Pflanzen der Geni Boea, Ramonda, Habelea, Chamaegigas und Selaginella, wie z. B. Selaginella lepidophylla sowie Überlebensfraktionen von proteinreichen angiospermen bzw. gymnospermen Pflanzen oder Mikroorganismen, wie z. B. Saccharomyces cerevisiae.
Extraktion Die Herstellung der Extrakte kann in an sich bekannter Weise erfolgen, d. h. beispielsweise durch wässrigen, alkoholischen oder wässrig-alkoholischen Auszug der Pflanzen bzw. Pflan- zenteile. Bezüglich der geeigneten herkömmlichen Extraktionsverfahren wie der Mazeration, der Remazeration, der Digestion, der Bewegungsmazeration, der Wirbelextraktion, Ultraschallextraktion, der Gegenstromextraktion, der Perkolation, der Reperkolation, der Evakolation (Extraktion unter vermindertem Druck), der Diakolation und Festflüssig-Extraktion unter kontinuierlichem Rückfluss, die in einem Soxhlet-Extraktor durchgeführt wird, die dem Fachmann geläufig und im Prinzip alle anwendbar sind, sei der Einfachheit halber beispielsweise auf Hagers Handbuch der Pharmazeutischen Praxis, (5.
Auflage, Bd. 2, S. 1026-1030, Springer Verlag, Berlin-Heidelberg-New-York 1991) verwiesen. Für den grosstechnischen Einsatz vorteilhaft ist die Perkolationsmethode. Als Ausgangsmaterial können frische Pflanzen oder Pflanzenteile eingesetzt werden, üblicherweise wird jedoch von getrockneten Pflanzen und/oder Pflanzenteilen ausgegangen, die vor der Extraktion mechanisch zerkleinert werden können. Hierbei eignen sich alle dem Fachmann bekannten Zerkleinerungsmethoden, als Beispiel sei die Gefriermahlung genannt.
Als Lösungsmittel für die Durchführung der Extraktionen können organische Lösungsmittel, Wasser (vorzugsweise heisses Wasser einer Temperatur von über 80 C und insbesondere von über 95 C) oder Gemische aus organischen Lösungsmitteln und Wasser, insbesondere niedermolekulare Alkohole mit mehr oder weniger hohen Wassergehalten, verwendet werden. Besonders bevorzugt ist die Extraktion mit destilliertem oder nicht destilliertem Wasser, Methanol, Ethanol, Pentan, Hexan, Heptan, Aceton, Propylenglykolen, Polyethylenglykolen sowie Ethylacetat sowie Mischungen hieraus sowie die wässrigen Gemische der organischen Lösungsmittel. Insbesondere bevorzugt ist die Extraktion mit destilliertem oder nicht destilliertem Wasser, Methanol, Ethanol sowie den wässrigen Lösungen der beiden Alkohole.
Die Extraktion erfolgt in der Regel bei 20 bis 100 C, bevor zugt bei 30 bis 90 C, insbesondere bei 60 bis 80 C. In einer bevorzugten Ausführungsform erfolgt die Extraktion unter Inertgasatmosphäre zur Vermeidung der Oxidation der Wirkstoffe des Extraktes. Dies ist insbesondere bei Extraktionen bei Temperaturen über 40 C von Bedeutung. Die Extraktionszeiten werden vom Fachmann in Abhängigkeit vom Ausgangsmaterial, dem Extraktionsverfahren, der Extraktionstemperatur, vom Verhältnis Lösungsmittel zu Rohstoff u. a. eingestellt. Nach der Extraktion können die erhaltenen Rohextrakte gegebenenfalls weiteren üblichen Schritten, wie beispielsweise Aufreinigung, Konzentration und/oder Entfärbung unterzogen werden.
Falls wünschenswert, können die so hergestellten Extrakte beispielsweise einer selektiven Abtrennung einzelner unerwünschter In haltsstoffe, unterzogen werden. Die Extraktion kann bis zu jedem beliebigen Extraktionsgrad erfolgen, wird aber gewöhnlich bis zur Erschöpfung durchgeführt. Typische Ausbeuten (= Trockensubstanzmenge des Extraktes bezogen auf eingesetzte Rohstoffmenge) bei der Extraktion getrockneter Blätter liegen im Bereich von 3 bis 20, insbesondere 6 bis 10 Gew.-%.
Die vorliegenden Erfindung umfasst die Erkenntnis, dass die Extraktionsbedingungen sowie die Ausbeuten der Endextrakte vom Fachmann je nach gewünschtem Einsatzgebiet gewählt werden können. Diese Extrakte, die in der Regel Aktivsubstanzgehalte (= Feststoffgehalte) im Bereich von 0,5 bis 10 Gew.-% aufweisen, können als solche eingesetzt werden, es ist jedoch ebenfalls möglich, das Lösungsmittel durch Trocknung, insbesondere durch Sprühoder Gefriertrocknung vollständig zu entfernen. Die Extrakte können auch als Ausgangsstoffe für die Gewinnung der reinen Wirkstoffe dienen, sofern diese nicht auf synthetischem Wege einfacher und kostengünstiger hergestellt werden können.
Wirkstoffe Anstelle der Extrakte können auch die in den Überlebensfraktionen enthaltenen Wirkstoffe einzeln oder in Mischungen eingesetzt werden, wobei es sich dabei sowohl um Produkte handeln kann, die durch Aufreinigung der Extrakte oder synthetisch gewonnen werden. Besonders bevorzugt sind die Produkte, die durch Aufreinigung aus den erfindungsgemässen Extrakten gewonnen werden können. Typische Beispiele für geeignete Wirkstoffe sind Osmolyte (z. B. Octulose, Sucrose, Glucose, Trehalose, Fructose, Glucosyl-9-glycerin, Xyloglucane, Methylester des Pektins), Terpene (z. B. Carvone, Perillalkohol), Antioxidantien (z. B. Arbutin, Anthocyane, Superoxid Dismutase, Glutathion Reduktase, Ascorbat Peroxydase) sowie Phytohormone (z. B. Abszisinsäure).
In einer besonderen Ausführungsform der Erfindung enthalten die Zubereitungen Extrakte, welche wirksame Gehalte an Osmolyten, Terpene, Antioxidantien und/oder Phytohormone aufweisen.
Besondere Bedeutung besitzen dabei Octulose, Arbutin, Abszisinsäure, sowie deren Mischungen. Die Extrakte werden in wirksamen Mengen eingesetzt, d. h. in Abhängigkeit der Menge der darin enthaltenen Wirkstoffe (= Feststoffmenge) in Konzentrationen von 0,001 bis 1, vor zugsweise 0,01 bis 0,1 Gew.-%-jeweils bezogen auf Wirkstoffmenge und Endzubereitung.
Für die reinen Wirkstoffe gelten die Mengenangaben entsprechend.
Gewerbliche Anwendbarkeit Weitere Gegenstände der Erfindung betreffen die Verwendung von Extrakten von Wiederauferstehungspflanzen zur Herstellung von kosmetischen und/oder pharmazeutischen Zubereitungen sowie als Wirkstoffe > zur Regulierung des Wasserhaushaltes in der Haut, bzw. zur Feuchtigkeitsregulierung der Haut > zur Stärkung des Zellmetabolismus zur Abwehr von schädigenden Umwelteinflüssen, insbesondere zur Zellschutzwirkung gegen Umwelteinflüsse wie beispielsweise Hitze schock, Kälteschock oder osmotischer Schock ;
> zum Schutz von Haut und Haaren gegen Schädigung durch UV-Strahlung, > zum Schutz von Haut und Haaren vor freien Radikalen sowie > zum Schutz der Makromoleküle in den Hautzellen und Zellmembranen.
Weitere Gegenstände der Erfindung betreffen schliesslich die Verwendung von Octulose, Arbutin und/oder Abszisinsäure zur Herstellung von kosmetischen und/oder pharmazeutischen Zubereitungen.
Kosmetische und/oder pharmazeutische Zubereitungen Die erfindungsgemässen Extrakte bzw. Wirkstoffe können zur Herstellung von kosmetischen und/oder pharmazeutischen Zubereitungen, wie beispielsweise Haarshampoos, Haarlotionen, Schaumbäder, Duschbäder, Cremes, Gele, Lotionen, alkoholische und wässrig/alkoholische Lösungen, Emulsionen, Wachs/Fett-Massen, Stiftpräparaten, Pudern oder Salben dienen.
Diese Mittel können ferner als weitere Hilfs-und Zusatzstoffe milde Tenside, Ölkörper, Emul- gatoren, Perlglanzwachse, Konsistenzgeber, Verdickungsmittel, Überfettungsmittel, Stabilsatoren, Polymere, Siliconverbindungen, Fette, Wachse, Lecithine, Phospholipide, biogene Wirkstoffe, UV-Lichtschutzfaktoren, Antioxidantien, Deodorantien, Antitranspirantien, Antischuppenmittel, Filmbildner, Quellmittel, Insektenrepellentien, Selbstbräuner, Tyrosininhibitoren (Depigmentierungsmittel), Hydrotrope, Solubilisatoren, Konservierungsmittel, Parfüm- öle, Farbstoffe und dergleichen enthalten.
Tenside Als oberflächenaktive Stoffe können anionische, nichtionische, kationische und/oder amphotere bzw. amphotere Tenside enthalten sein, deren Anteil an den Mitteln üblicherweise bei etwa 1 bis 70, vorzugsweise 5 bis 50 und insbesondere 10 bis 30 Gew.-% beträgt. Typische Beispiele für anionische Tenside sind Seifen, Alkylbenzolsulfonate, Alkansulfonate, Olefinsulfonate, Alkylethersulfonate, Glycerinethersulfonate, a-Methylestersulfonate, Sulfofettsäuren, Alkylsulfate, Fettalkoholethersulfate, Glycerinethersulfate, Fettsäureethersulfate, Hydroxymischethersulfate, Monoglycerid (ether) sulfate, Fettsäureamid (ether) sulfate, Mono-und Dialkylsulfosuccinate, Mono-und Dialkylsulfosuccinamate, Sulfotriglyceride, Amidseifen, Ethercarbonsäuren und deren Salze, Fettsäureisethionate, Fettsäuresarcosinate,
Fettsäuretauride, N-Acylaminosäuren, wie beispielsweise Acyllactylate, Acyltartrate, Acylglutamate und Acylaspartate, Alkyloligoglucosidsulfate, Proteinfettsäurekondensate (insbesondere pflanzliche Produkte auf Weizenbasis) und Alkyl (ether) phosphate. Sofern die anionischen Tenside Polyglycoletherketten enthalten, können diese eine konventionelle, vorzugsweise jedoch eine eingeengte Homologenverteilung aufweisen. Typische Beispiele für nichtionische Tenside sind Fettalkoholpolyglycolether, Alkylphenolpolyglycolether, Fettsäurepolyglycolester, Fettsäureamidpolyglycolether, Fettaminpolyglycolether, alkoxylierte Triglyceride, Mischether bzw.
Mischformale, gegebenenfalls partiell oxidierte Alk (en) yloligoglykoside bzw. Glucoronsäurederivate, Fettsäure-N-alkylglucamide, Proteinhydrolysate (insbesondere pflanzliche Produkte auf Weizenbasis), Polyolfettsäureester, Zuckerester, Sorbitanester, Polysorbate und Aminoxide. Sofern die nichtionischen Tenside Polyglycoletherketten enthalten, können diese eine konventionelle, vorzugsweise jedoch eine eingeengte Homologenverteilung aufweisen. Typische Beispiele für kationische Tenside sind quartäre Ammoniumverbindungen, wie beispielsweise das Dimethyldistearylammoniumchlorid, und Esterquats, insbesondere quaternierte Fettsäuretrialkanolaminestersalze. Typische Beispiele für amphotere bzw. zwitterionische Tenside sind Alkylbetaine, Alkylamidobetaine, Aminopropionate, Aminoglycinate, Imidazoliniumbetaine und Sulfobetaine.
Bei den genannten Tensiden handelt es sich ausschliesslich um bekannte Verbindungen. Hinsichtlich Struktur und Herstellung dieser Stoffe sei auf ein schlägige Übersichtsarbeiten beispielsweise J. Falbe (ed.),"Surfactants in Consumer Products", Springer Verlag, Berlin, 1987, S. 54-124 oder J. Falbe (ed.),"Katalysatoren, Tenside und Mineralöladditive", Thieme Verlag, Stuttgart, 1978, S. 123217 verwiesen.
Typische Beispiele für besonders geeignete milde, d. h. besonders hautvertägliche Tenside sind Fettalkoholpolyglycolethersulfate, Monoglyceridsulfate, Monound/oder Dialkylsulfosuccinate, Fettsäureisethionate, Fettsäuresarcosinate, Fettsäuretauride, Fettsäureglutamate, a-Olefinsulfonate, Ethercarbonsäuren, Alkyloligoglucoside, Fettsäureglucamide, Alkylamidobetaine, Amphoacetale und/oder Proteinfettsäurekondensate, letztere vorzugsweise auf Basis von Weizenproteinen.
Ölkörper Als Ölkörper kommen beispielsweise Guerbetalkohole auf Basis von Fettalkoholen mit 6 bis 18, vorzugsweise 8 bis 10 Kohlenstoffatomen, Ester von linearen C6-C22-Fettsäuren mit linearen oder verzweigten C6-C22-Fettalkoholen bzw. Ester von verzweigten Ce-Cis- Carbonsäuren mit linearen oder verzweigten C6-C22-Fettalkoholen, wie z. B.
Myristylmyristat, Myristylpalmitat, Myristylstearat, Myristylisostearat, Myristyloleat, Myristylbehenat, Myristylerucat, Cetylmyristat, Cetylpalmitat, Cetylstearat, Cetylisostearat, Cetyloleat, Cetylbehenat, Cetylerucat, Stearylmyristat, Stearylpalmitat, Stearylstearat, Stearylisostearat, Stearyloleat, Stearylbehenat, Stearylerucat, Isostearylmyristat, Isostearylpalmitat, Isostearylstearat, I sostearylisostearat, Isostearyloleat, Isostearylbehenat, Isostearyloleat, Oleylmyristat, Oleylpalmitat, Oleylstearat, Oleylisostearat, Oleyloleat, Oleylbehenat, Oleylerucat, Behenylmyristat, Behenylpalmitat, Behenylstearat, Behenylisostearat, Behenyloleat, Behenylbehenat, Behenylerucat, Erucylmyristat, Erucylpalmitat, Erucylstearat, Erucylisostearat, Erucyloleat,
Erucylbehenat und Erucylerucat. Daneben eignen sich Ester von linearen C6-C22-Fettsäuren mit verzweigten Alkoholen, insbesondere 2-Ethylhexanol, Ester von Cl8-C38-Alkylhy- droxycarbonsäuren mit linearen oder verzweigten C6-C22-Fettalkoholen (vgl. DE 19756377 A1), insbesondere Dioctyl Malate, Ester von linearen und/oder verzweigten Fettsäuren mit mehrwertigen Alkoholen (wie z.
B. Propylenglycol, Dimerdiol oder Trimertriol) und/oder Guerbetalkoholen, Triglyceride auf Basis C6-Clo-Fettsäuren, flüssige Mono-/Di- /Triglyceridmischungen auf Basis von C6-Cl8-Fettsäuren, Ester von C6-C2z-Fettalkoholen und/oder Guerbetalkoholen mit aromatischen Carbonsäuren, insbesondere Benzoesäure, Ester von C2-C12-Dicarbonsäuren mit linearen oder verzweigten Alkoholen mit 1 bis 22 Kohlenstoffatomen oder Polyolen mit 2 bis 10 Kohlenstoffatomen und 2 bis 6 Hydroxylgruppen, pflanzliche Öle, verzweigte primäre Alkohole, substituierte Cyclohexane, lineare und verzweigte C6-C22-Fettalkoholcarbonate, wie z. B.
Dicaprylyl Carbonate (Cetiol0 CC), Guerbetcarbonate auf Basis von Fettalkoholen mit 6 bis 18, vorzugsweise 8 bis 10 C Atomen, Ester der Benzoesäure mit linearen und/oder verzweigten C6-C22-Alkoholen (z. B. Finso) v@ TN), lineare oder verzweigte, symmetrische oder unsymmetrische Dialkylether mit 6 bis 22 Kohlenstoffatomen pro Alkylgruppe, wie z. B. Dicaprylyl Ether (Cetiol0 OE), Ringöffnungsprodukte von epoxidierten Fettsäureestern mit Polyolen, Siliconöle (Cyclomethicone, Siliciummethicontypen u. a.) und/oder aliphatische bzw. naphthenische Kohlenwasserstoffe, wie z. B. wie Squalan, Squalen oder Dialkylcyclohexane in Betracht.
Emulgatoren Als Emulgatoren kommen beispielsweise nichtionogene Tenside aus mindestens einer der folgenden Gruppen in Frage :
Anlagerungsprodukte von 2 bis 30 Mol Ethylenoxid und/oder 0 bis 5 Mol Propylenoxid an lineare Fettalkohole mit 8 bis 22 C-Atomen, an Fettsäuren mit 12 bis 22 C-Atomen, an Alkylphenole mit 8 bis 15 C-Atomen in der Alkylgruppe sowie Alkylamine mit 8 bis 22
Kohlenstoffatomen im Alkylrest ;
Alkyl-und/oder Alkenyloligoglykoside mit 8 bis 22 Kohlenstoffatomen im Alk (en) ylrest und deren ethoxylierte Analoga ;
Anlagerungsprodukte von 1 bis 15 Mol Ethylenoxid an Ricinusöl und/oder gehärtetes
Ricinusöl ;
Anlagerungsprodukte von 15 bis 60 Mol Ethylenoxid an Ricinusöl und/oder gehärtetes
Ricinusöl ;
Partialester von Glycerin und/oder Sorbitan mit ungesättigten, linearen oder gesättigten, verzweigten Fettsäuren mit 12 bis 22 Kohlenstoffatomen und/oder Hydroxycarbonsäuren mit 3 bis 18 Kohlenstoffatomen sowie deren Addukte mit 1 bis 30 Mol Ethylenoxid ;
Partialester von Polyglycerin (durchschnittlicher Eigenkondensationsgrad 2 bis 8), Poly ethylenglycol (Molekulargewicht 400 bis 5000), Trimethylolpropan, Pentaerythrit, Zu ckeralkoholen (z. B. Sorbit), Alkylglucosiden (z. B.
Methylglucosid, Butylglucosid, Lau rylglucosid) sowie Polyglucosiden (z. B. Cellulose) mit gesättigten und/oder ungesättig ten, linearen oder verzweigten Fettsäuren mit 12 bis 22 Kohlenstoffatomen und/oder
Hydroxycarbonsäuren mit 3 bis 18 Kohlenstoffatomen sowie deren Addukte mit 1 bis 30
Mol Ethylenoxid ; > Mischester aus Pentaerythrit, Fettsäuren, Citronensäure und Fettalkohol gemäss DE
1165574 PS und/oder Mischester von Fettsäuren mit 6 bis 22 Kohlenstoffatomen,
Methylglucose und Polyolen, vorzugsweise Glycerin oder Polyglycerin.
Mono-, Di-und Trialkylphosphate sowie Mono-, Di-und/oder Tri-PEG-alkylphosphate und deren Salze ; > Wollwachsalkohole ; Polysiloxan-Polyalkyl-Polyether-Copolymere bzw. entsprechende Derivate ;
Block-Copolymere z. B. Polyethylenglycol-30 Dipolyhydroxystearate ; Polymeremulgatoren, z. B. Pemulen-Typen (TR-1, TR-2) von Goodrich ; Polyalkylenglycole sowie
Glycerincarbonat.
Ethylenoxidanlagerunqsprodukte
Die Anlagerungsprodukte von Ethylenoxid und/oder von Propylenoxid an Fettalkohole,
Fettsäuren, Alkylphenole oder an Ricinusöl stellen bekannte, im Handel erhältliche Pro dukte dar. Es handelt sich dabei um Homologengemische, deren mittlerer Alkoxy lierungsgrad dem Verhältnis der Stoffmengen von Ethylenoxid und/oder Propylenoxid und Substrat, mit denen die Anlagerungsreaktion durchgeführt wird, entspricht. Civils-
Fettsäuremono-und-diester von Anlagerungsprodukten von Ethylenoxid an Glycerin sind aus DE 2024051 PS als Rückfettungsmittel für kosmetische Zubereitungen be kannt.
Alkyl-und/oder Alkenyloligoglykke
Alkyl-und/oder Alkenyloligoglycoside, ihre Herstellung und ihre Verwendung sind aus dem Stand der Technik bekannt. Ihre Herstellung erfolgt insbesondere durch Umsetzung von Glucose oder Oligosacchariden mit primären Alkoholen mit 8 bis 18 Kohlenstoffato men. Bezüglich des Glycosidrestes gilt, dass sowohl Monoglycoside, bei denen ein cycli scher Zuckerrest glycosidisch an den Fettalkohol gebunden ist, als auch oligomere Gly coside mit einem Oligomerisationsgrad bis vorzugsweise etwa 8 geeignet sind. Der Oli gomerisierungsgrad ist dabei ein statistischer Mittelwert, dem eine für solche techni schen Produkte übliche Homologenverteilung zugrunde liegt.
Partialglyceride
Typische Beispiele für geeignete Partialglyceride sind Hydroxystearinsäuremonoglycerid,
Hydroxystearinsäurediglycerid, Isostearinsäuremonoglycerid, Isostearinsäurediglycerid, Ölsäuremonoglycerid, Ölsäurediglycerid, Ricinolsäuremoglycerid, Ricinolsäurediglycerid,
Linolsäuremonoglycerid, Linolsäurediglycerid, Linolensäuremonoglycerid, Linolensäure diglycerid, Erucasäuremonoglycerid, Erucasäurediglycerid, Weinsäuremonoglycerid,
Weinsäurediglycerid, Citronensäuremonoglycerid, Citronendiglycerid, Äpfelsäuremo noglycerid, Äpfelsäurediglycerid sowie deren technische Gemische, die untergeordnet aus dem Herstellungsprozess noch geringe Mengen an Triglycerid enthalten können. E benfalls geeignet sind Anlagerungsprodukte von 1 bis 30, vorzugsweise 5 bis 10 Mol E thylenoxid an die genannten Partialglyceride.
Sorbitanester
Als Sorbitanester kommen Sorbitanmonoisostearat, Sorbitansesquiisostearat, Sorbitan diisostearat, Sorbitantriisostearat, Sorbitanmonooleat, Sorbitansesquioleat, Sorbitan dioleat, Sorbitantrioleat, Sorbitanmonoerucat, Sorbitansesquierucat, Sorbitandierucat, Sorbitantrierucat, Sorbitanmonoricinoleat, Sorbitansesquiricinoleat, Sorbitandiricinoleat, Sorbitantriricinoleat, Sorbitanmonohydroxystearat, Sorbitansesquihydroxystearat, Sorbitandihydroxystearat, Sorbitantrihydroxystearat, Sorbitanmonotartrat, Sorbitansesquitartrat, Sorbitanditartrat, Sorbitantritartrat, Sorbitanmonocitrat, Sorbitansesquicitrat, Sorbitandicitrat, Sorbitantricitrat, Sorbitanmonomaleat, Sorbitansesquimaleat, Sorbitandimaleat, Sorbitantrimaleat sowie deren technische Gemische.
Ebenfalls geeignet sind Anlagerungsprodukte von 1 bis 30, vorzugsweise 5 bis 10 Mol Ethylenoxid an die genannten Sorbitanester.
Polyglycerinester Typische Beispiele für geeignete Polyglycerinester sind Polyglyceryl-2 Dipolyhydroxystearate (Dehymuls0 PGPH), Polyglycerin-3-Diisostearate (Lameforme TGI), Polyglyceryl-4 Isostearate (Iso ! an@ GI 34), Polyglyceryl-3 Oleate, Diisostearoyl Polyglyceryl-3 Diisostearate (Iso) an@ PDI), Polyglyceryl-3 Methylglucose Distearate (Tego Care@ 450), Polyglyceryl-3 Beeswax (Cera Bellina3), Polyglyceryl-4 Caprate (Polyglycerol Caprate T2010/90), Polyglyceryl-3 Cetyl Ether (Chimexanee NL), Polyglyceryl-3 Distearate (Cre mophord3 GS 32) und Polyglyceryl Polyricinoleate (AdmulQ3 WOL 1403) Polyglyceryl Dimerate Isostearate sowie deren Gemische.
Beispiele für weitere geeignete Polyolester sind die gegebenenfalls mit 1 bis 30 Mol Ethylenoxid umgesetzten Mono-, Di-und Triester von Trimethylolpropan oder Pentaerythrit mit Laurinsäure, Kokosfettsäure, Talgfettsäure, Palmitinsäure, Stearinsäure, Ölsäure, Behensäure und dergleichen.
Anionische Emulgatoren Typische anionische Emulgatoren sind aliphatische Fettsäuren mit 12 bis 22 Kohlenstoffatomen, wie beispielsweise Palmitinsäure, Stearinsäure oder Behensäure, sowie Dicarbonsäuren mit 12 bis 22 Kohlenstoffatomen, wie beispielsweise Azelainsäure oder Sebacinsäure.
Amphothere und kationische Emulgatoren Weiterhin können als Emulgatoren zwitterionische Tenside verwendet werden. Als zwitterionische Tenside werden solche oberflächenaktiven Verbindungen bezeichnet, die im Molekül mindestens eine quartäre Ammoniumgruppe und mindestens eine Carboxylatund eine Sulfonatgruppe tragen. Besonders geeignete zwitterionische Tenside sind die sogenannten Betaine wie die N-Alkyl-N, N-dimethylammoniumglycinate, beispielsweise das Kokosalkyldimethylammoniumglycinat, N-Acylaminopropyl-N, N-dimethylammonium glycinate, beispielsweise das Kokosacylaminopropyldimethyf-ammoniumglycinat, und 2
Alkyl-3-carboxylmethyl-3-hydroxyethylimidazoline mit jeweils 8 bis 18 C-Atomen in der
Alkyl-oder Acylgruppe sowie das Kokosacylaminoethylhydroxyethylcarboxymethyl glycinat.
Besonders bevorzugt ist das unter der CTFA-Bezeichnung Cocamidopropyl Be taine bekannte Fettsäureamid-Derivat. Ebenfalls geeignete Emulgatoren sind ampholyti sche Tenside. Unter ampholytischen Tensiden werden solche oberflächenaktiven Verbin dungen verstanden, die ausser einer C8/18-Alkyl-oder Acylgruppe im Molekül mindestens eine freie Aminogruppe und mindestens eine-COOH-oder-SO3H-Gruppe enthalten und zur Ausbildung innerer Salze befähigt sind. Beispiele für geeignete ampholytische Tensi de sind N-Alkylglycine, N-Alkylpropion-säuren, N-Alkylaminobuttersäuren, N
Alkyliminodipropionsäuren, N-Hydroxyethyl-N-alkylamidopropylglycine, N-Alkyltaurine,
N-Alkylsarcosine, 2-Alkylaminopropionsäuren und Alkylaminoessigsäuren mit jeweils et wa 8 bis 18 C-Atomen in der Alkylgruppe..
Besonders bevorzugte ampholytische Tenside sind das N-Kokosalkylaminopropionat, das Kokosacylaminoethylaminopropionat und das C12/l8-Acylsarcosin. Schliesslich kommen auch Kationtenside als Emulgatoren in Betracht, wobei solche vom Typ der Esterquats, vorzugsweise methylquaternierte Difettsäu retriethanolaminester-Salze, besonders bevorzugt sind.
Fette und Wachse Typische Beispiele für Fette sind Glyceride, d. h. feste oder flüssige pflanzliche oder tierische Produkte, die im wesentlichen aus gemischten Glycerinestern höherer Fettsäuren bestehen, als Wachse kommen u. a. natürliche Wachse, wie z. B. Candelillawachs, Carnaubawachs, Japanwachs, Espartograswachs, Korkwachs, Guarumawachs, Reiskeimölwachs, Zuckerrohrwachs, Ouricurywachs, Montanwachs, Bienenwachs, Schellackwachs, Walrat, Lanolin (Woll- wachs), Bürzelfett, Ceresin, Ozokerit (Erdwachs), Petrolatum, Paraffinwachse, Mikrowachse ; chemisch modifizierte Wachse (Hartwachse), wie z. B. Montanesterwachse, Sasolwachse, hydrierte Jojobawachse sowie synthetische Wachse, wie z. B. Polyalkylenwachse und Polyethylenglycolwachse in Frage.
Neben den Fetten kommen als Zusatzstoffe auch fettähnliche Substanzen, wie Lecithine und Phospholipide in Frage. Unter der Bezeichnung Lecithine versteht der Fachmann diejenigen Glycero-Phospholipide, die sich aus Fettsäuren, Glycerin, Phosphorsäure und Cholin durch Veresterung bilden. Lecithine werden in der Fachwelt daher auch häufig als Phosphatidylcholine (PC). Als Beispiele für natürliche Lecithine seien die Kephalin genannt, die auch als Phosphatidsäuren bezeichnet werden und Derivate der 1,2 Diacyl-sn-glycerin-3-phosphorsäuren darstellen. Dem gegenüber versteht man unter Phospholipiden gewöhnlich Mono-und vorzugsweise Diester der Phosphorsäure mit Glycerin (Glycerinphosphate), die allgemein zu den Fetten gerechnet werden. Daneben kommen auch Sphingosine bzw. Sphingolipide in Frage.
Perlglanzwachse Als Periglanzwachse kommen beispielsweise in Frage : Alkylenglycolester, speziell Ethylengly coldistearat ; Fettsäurealkanolamide, speziell Kokosfettsäurediethanolamid ; Partialglyceride, speziell Stearinsäuremonoglycerid ; Ester von mehrwertigen, gegebenenfalls hydroxysubstituierte Carbonsäuren mit Fettalkoholen mit 6 bis 22 Kohlenstoffatomen, speziell langkettige Ester der Weinsäure ; Fettstoffe, wie beispielsweise Fettalkohole, Fettketone, Fettaldehyde, Fettether und Fettcarbonate, die in Summe mindestens 24 Kohlenstoffatome aufweisen, speziell Lauron und Distearylether ;
Fettsäuren wie Stearinsäure, Hydroxystearinsäure oder Behensäure, Ringöffnungsprodukte von Olefinepoxiden mit 12 bis 22 Kohlenstoffatomen mit Fettalkoholen mit 12 bis 22 Kohlenstoffatomen und/oder Polyolen mit 2 bis 15 Kohlenstoffatomen und 2 bis 10 Hydroxylgruppen sowie deren Mischungen.
Konsistenzgener und Verdickungsmittel Als Konsistenzgeber kommen in erster Linie Fettalkohole oder Hydroxyfettalkohole mit 12 bis 22 und vorzugsweise 16 bis 18 Kohlenstoffatomen und daneben Partialglyceride, Fettsäuren oder Hydroxyfettsäuren in Betracht. Bevorzugt ist eine Kombination dieser Stoffe mit Alkyloligoglucosiden und/oder Fettsäure-N-methylglucamiden gleicher Kettenlänge und/oder Polyglycerinpoly-12-hydroxystearaten. Geeignete Verdickungsmittel sind beispielsweise Aerosil Typen (hydrophile Kieselsäuren), Polysaccharide, insbesondere Xanthan-Gum, Guar-Guar, Agar-Agar, Alginate und Tylosen, Carboxymethylcellulose und Hydroxyethyl-und Hydroxypropylcellulose, ferner höhermolekulare Polyethylenglycolmono-und-diester von Fettsäuren, Polyacrylate, (z.
B. CarbopoleX und Pemulen-Typen von Goodrich ; Synthalene0 von Sigma ; Keltrol-Typen von Kelco ; Sepigel-Typen von Seppic ; Salcare-Typen von Allied Colloids), Polyacrylamide, Polymere, Polyvinylalkohol und Polyvinylpyrrolidon. Als besonders wirkungsvoll haben sich auch Bentonite, wie z. B. Bentone0 Gel VS-5PC (Rheox) erwiesen, bei dem es sich um eine Mischung aus Cyclopentasiloxan, Disteardimonium Hectorit und Propylencarbonat handelt. Weiter in Frage kommen Tenside, wie beispielsweise ethoxylierte Fettsäureglyceride, Ester von Fettsäuren mit Polyolen wie beispielsweise Pentaerythrit oder Trimethylolpropan, Fettalkoholethoxylate mit eingeengter Homologenverteilung oder Alkyloligoglucoside sowie Elektrolyte wie Kochsalz und Ammoniumchlorid.
Überfettunqsmittel Als Überfettungsmittel können Substanzen wie beispielsweise Lanolin und Lecithin sowie polyethoxylierte oder acylierte Lanolin-und Lecithinderivate, Polyolfettsäureester, Monogly ceride und Fettsäurealkanolamide verwendet werden, wobei die letzteren gleichzeitig als Schaumstabilisatoren dienen.
Stabilisatoren Als Stabilisatoren können Metallsalze von Fettsäuren, wie z. B. Magnesium-, Aluminiumund/oder Zinkstearat bzw.-ricinoleat eingesetzt werden.
Polymere Geeignete kationische Polymere sind beispielsweise kationische Cellulosederivate, wie z. B. eine quaternierte Hydroxyethylcellulose, die unter der Bezeichnung Polymer JR 400@ von Amerchol erhältlich ist, kationische Stärke, Copolymere von Diallylammoniumsalzen und Acrylamiden, quaternierte Vinylpyrrolidon/Vinylimidazol-Polymere, wie z. B. Luviquate (BASF), Kondensationsprodukte von Polyglycolen und Aminen, quaternierte Kollagenpolypeptide, wie beispielsweise Lauryidimonium Hydroxypropyl Hydrolyzed Collagen (Lamequatd3L/Grünau), quaternierte Weizenpolypeptide, Polyethylenimin, kationische Siliconpolymere, wie z. B.
Amodimethicone, Copolymere der Adipinsäure und Dimethylaminohydroxypropyldiethylentriamin (Cartaretine@/Sandoz), Copolymere der Acrylsäure mit Dimethyl-diallylammoniumchlorid (Merquate 550/Chemviron), Polyaminopolyamide, wie z. B. beschrieben in der FR 2252840 A sowie deren vernetzte wasserlöslichen Polymere, kationische Chitinderivate wie beispielsweise quaterniertes Chitosan, gegebenenfalls mikrokristallin verteilt, Kondensationsprodukte aus Dihalogenalkylen, wie z. B. Dibrombutan mit Bisdialkylaminen, wie z. B. Bis Dimethylamino-1, 3-propan, kationischer Guar-Gum, wie z. B. Jaguar@ CBS, Jaguar@ C-17, Jaguar@ C-16 der Firma Celanese, quaternierte Ammoniumsalz-Polymere, wie z.
B. Mirapo ! @ A-15, Mirapolo AD-1, Mirapole AZ-1 der Firma Miranol.
Als anionische, zwitterionische, amphotere und nichtionische Polymere kommen beispielswei- se Vinylacetat/Crotonsäure-Copolymere, Vinylpyrrolidon/Vinylacrylat-Copolymere, Vinylacetat/Butylmaleat/Isobornylacrylat-Copolymere, Methylvinylether/Maleinsäureanhydrid-Copolymere und deren Ester, unvernetzte und mit Polyolen vernetzte Polyacrylsäuren, Acrylamidopropyltrimethylammoniumchlorid/Acrylat-Copolymere, Octylacrylamid/Methylmeth-acry lat/tert. Butylaminoethylmethacrylat/2-Hydroxypropylmethacrylat-Copolymere, Polyvinylpyr- rolidon, Vinylpyrrolidon/Vinylacetat-Copolymere, Vinylpyrrolidon/Dimethylaminoethyl- methacrylat/Vinylcaprolactam-Terpolymere sowie gegebenenfalls derivatisierte Celluloseether und Silicone in Frage.
Weitere geeignete Polymere und Verdickungsmittel sind in Cosm. Toil.
108, 95 (1993) aufgeführt.
Siliconverbindungen Geeignete Siliconverbindungen sind beispielsweise Dimethylpolysiloxane, Methylphenylpolysiloxane, cyclische Silicone sowie amino-, fettsäure-, alkohol-, polyether-, epoxy-, fluor-, glykosid-und/oder alkylmodifizierte Siliconverbindungen, die bei Raumtemperatur sowohl flüssig als auch harzförmig vorliegen können. Weiterhin geeignet sind Simethicone, bei denen es sich um Mischungen aus Dimethiconen mit einer durchschnittlichen Kettenlänge von 200 bis 300 Dimethylsiloxan-Einheiten und hydrierten Silicaten handelt. Eine detaillierte Übersicht über geeignete flüchtige Silicone findet sich zudem von Todd et al. in Cosm. Toil. 91, 27 (1976).
UV-Lichtschutzfilter und Antioxidantien Neben den erfindungsgemässen Extrakten bzw. den wirksamen Gehalten an Wirkstoffen in diesen Extrakten als Wirkstoffe gegen die Schädigungen durch UV-Strahlung können noch weitere UV-Lichtschutzfaktoren eingesetzt werden.
Unter UV-Lichtschutzfaktoren sind beispielsweise bei Raumtemperatur flüssig oder kristallin vorliegende organische Substanzen (Lichtschutzfilter) zu verstehen, die in der Lage sind, ultraviolette Strahlen zu absorbieren und die aufgenommene Energie in Form längerwelliger Strahlung, z. B. Wärme wieder abzugeben. UVB-Filter können öllöslich oder wasserlöslich sein. Als öllösliche Substanzen sind z. B. zu nennen : > 3-Benzylidencampher bzw. 3-Benzylidennorcampher und dessen Derivate, z.
B. 3- (4-
Methylbenzyliden) campher wie in der EP 0693471 B1 beschrieben ; > 4-Aminobenzoesäurederivate, vorzugsweise 4- (Dimethylamino) benzoesäure-2-ethyl- hexylester, 4- (Dimethylamino) benzoesäure-2-octylester und 4- (Dimethylamino) benzoe säureamylester ; > Ester der Zimtsäure, vorzugsweise 4-Methoxyzimtsäure-2-ethylhexylester, 4-Methoxy zimtsäurepropylester, 4-Methoxyzimtsäureisoamylester 2-Cyano-3,3-phenylzimtsäure-2 ethylhexylester (Octocrylene) ; > Ester der Salicylsäure, vorzugsweise Salicylsäure-2-ethylhexylester, Salicylsäure-4-iso propylbenzylester, Salicylsäurehomomenthylester ;
> Derivate des Benzophenons, vorzugsweise 2-Hydroxy-4-methoxybenzophenon, 2 Hydroxy-4-methoxy-4'-methylbenzophenon, 2,2-Dihydroxy-4-methoxybenzophenon ; > Ester der Benzalmalonsäure, vorzugsweise 4-Methoxybenzmalonsäuredi-2-ethylhexyl ester ; > Triazinderivate, wie z. B. 2,4,6-Trianilino-(p-carbo-2-ethyl-1-hexyloxy)-1,3,5-triazin und
Octyl Triazon, wie in der EP 0818450 AI beschrieben oder Dioctyl Butamido Triazone (Uvasorbd3 HEB) ; Propan-1, 3-dione, wie z. B. 1-(4-tert. Butylphenyl)-3-(4methoxyphenyl) propan-1, 3-dion ; > Ketotricyclo (5.2.1.0) decan-Derivate, wie in der EP 0694521 B1 beschrieben.
Als wasserlösliche Substanzen kommen in Frage : > 2-Phenylbenzimidazol-5-sulfonsäure und deren Alkali-, Erdalkali-, Ammonium-, Alkylam monium-, Alkanolammonium-und Glucammoniumsalze ; > Sulfonsäurederivate von Benzophenonen, vorzugsweise 2-Hydroxy-4-methoxybenzo phenon-5-sulfonsäure und ihre Salze ; > Sulfonsäurederivate des 3-Benzylidencamphers, wie z. B. 4- (2-Oxo-3-bornylidenme- thyl) benzolsulfonsäure und 2-Methyl-5- (2-oxo-3-bornyliden) sulfonsäure und deren Salze.
Als typische UV-A-Filter kommen insbesondere Derivate des Benzoylmethans in Frage, wie beispielsweise 1-(4-tert. Butylphenyl)-3-(4-methoxyphenyl) propan-1, 3-dion, 4-tert.-Butyl-4- methoxydibenzoylmethan (Parsolo 1789), 1-Phenyl-3-(4-isopropylphenyl)-propan-1, 3-dion sowie Enaminverbindungen, wie beschrieben in der DE 19712033 AI (BASF). Die UV-A und UV-B-Filter können selbstverständlich auch in Mischungen eingesetzt werden. Besonders günstige Kombinationen bestehen aus den Derivate des Benzoylmethans"z.
B. 4-tert.-Butyl- e-methoxydibenzoyimethan (Parsoi@ 1789) und 2-Cyano-3,3-phenylzimtsäure-2-ethylhexylester (Octocrylene) in Kombination mit Ester der Zimtsäure, vorzugsweise 4 Methoxyzimtsäure-2-ethylhexylester und/oder 4-Methoxyzimtsäurepropylester und/oder 4 Methoxyzimtsäureisoamylester. Vorteilhaft werden deartige Kombinationen mit wasserlöslichen Filtern wie z. B. 2-Phenylbenzimidazol-5-sulfonsäure und deren Alkali-, Erdalkali-, Ammonium-, Alkylammonium-, Alkanolammonium-und Glucammoniumsalze kombiniert.
Neben den genannten löslichen Stoffen kommen für diesen Zweck auch unlösliche Lichtschutzpigmente, nämlich feindisperse Metalloxide bzw. Salze in Frage. Beispiele für geeignete Metalloxide sind insbesondere Zinkoxid und Titandioxid und daneben Oxide des Eisens, Zirkoniums, Siliciums, Mangans, Aluminiums und Cers sowie deren Gemische. Als Salze können Silicate (Talk), Bariumsulfat oder Zinkstearat eingesetzt werden. Die Oxide und Salze werden in Form der Pigmente für hautpflegende und hautschützende Emulsionen und dekorative Kosmetik verwendet. Die Partikel sollten dabei einen mittleren Durchmesser von weniger als 100 nm, vorzugsweise zwischen 5 und 50 nm und insbesondere zwischen 15 und 30 nm aufweisen.
Sie können eine sphärische Form aufweisen, es können jedoch auch solche Partikel zum Einsatz kommen, die eine ellipsoide oder in sonstiger Weise von der sphäri schen Gestalt abweichende Form besitzen. Die Pigmente können auch oberflächenbehandelt, d. h. hydrophilisiert oder hydrophobiert vorliegen. Typische Beispiele sind gecoatete Titandioxide, wie z. B. Titandioxid T 805 (Degussa) oder Eusolex T2000 (Merck). Als hydrophobe Coatingmittel kommen dabei vor allem Silicone und dabei speziell Trialkoxyoctylsilane oder Simethicone in Frage. In Sonnenschutzmitteln werden bevorzugt sogenannte Mikro-oder Nanopigmente eingesetzt. Vorzugsweise wird mikronisiertes Zinkoxid verwendet. Weitere geeignete UV-Lichtschutzfilter sind der Übersicht von P.
Finkel in SÖFW-Journal 122,543 (1996) sowie Parf. Kosm. 3 11 (1999) zu entnehmen.
Neben den beiden vorgenannten Gruppen primärer Lichtschutzstoffe können auch sekundäre Lichtschutzmittel vom Typ der Antioxidantien eingesetzt werden, die die photochemische Reaktionskette unterbrechen, welche ausgelöst wird, wenn UV-Strahlung in die Haut eindringt. Typische Beispiele hierfür sind Aminosäuren (z. B. Glycin, Histidin, Tyrosin, Tryptophan) und deren Derivate, Imidazole (z. B. Urocaninsäure) und deren Derivate, Peptide wie D, L-Carnosin, D-Carnosin, L-Carnosin und deren Derivate (z. B. Anserin), Carotinoide, Carotine (z. B. a-Carotin, ss-Carotin, Lycopin) und deren Derivate, Chlorogensäure und deren Derivate, Liponsäure und deren Derivate (z. B. Dihydroliponsäure), Aurothioglucose, Propylthiouracil und andere Thiole (z. B.
Thioredoxin, Glutathion, Cystein, Cystin, Cystamin und deren Glycosyl-, N-Acetyl-, Methyl-, Ethyl-, Propyl-, Amyl-, Butyl-und Lauryl-, Palmitoyl-, Oleyl-, y- Linoleyl-, Cholesteryl-und Glycerylester) sowie deren Salze, Dilaurylthiodipropionat, Distearylthiodipropionat, Thiodipropionsäure und deren Derivate (Ester, Ether, Peptide, Lipide, Nukleotide, Nukleoside und Salze) sowie Sulfoximinverbindungen (z. B. Buthioninsulfoximine, Homocysteinsulfoximin, Butioninsulfone, Penta-, Hexa-, Heptathioninsulfoximin) in sehr geringen verträglichen Dosierungen (z. B. pmol bis limol/kg), ferner (Metall)-Chelatoren (z.
B. a Hydroxyfettsäuren, Palmitinsäure, Phytinsäure, Lactoferrin), a-Hydroxysäuren (z. B. Citronensäure, Milchsäure, Äpfelsäure), Huminsäure, Gallensäure, Gallenextrakte, Bilirubin, Biliverdin, EDTA, EGTA und deren Derivate, ungesättigte Fettsäuren und deren Derivate (z. B. y- Linolensäure, Linolsäure, Ölsäure), Folsäure und deren Derivate, Ubichinon und Ubichinol und deren Derivate, Vitamin C und Derivate (z. B. Ascorbylpalmitat, Mg-Ascorbylphosphat, Ascorbylacetat), Tocopherole und Derivate (z. B.
Vitamin-E-acetat), Vitamin A und Derivate (Vitamin-A-palmitat) sowie Koniferylbenzoat des Benzoeharzes, Rutinsäure und deren Derivate, a-Glycosylrutin, Ferulasäure, Furfurylidenglucitol, Carnosin, Butylhydroxytoluol, Butylhydroxyanisol, Nordihydroguajakharzsäure, Nordihydroguajaretsäure, Trihydroxybutyrophe- non, Harnsäure und deren Derivate, Mannose und deren Derivate, Superoxid-Dismutase, Zink und dessen Derivate (z. B. ZnO, ZnS04) Selen und dessen Derivate (z. B.
Selen Methionin), Stilbene und deren Derivate (z. B. Stilbenoxid, trans-Stilbenoxid) und die erfindungsgemäss geeigneten Derivate (Salze, Ester, Ether, Zucker, Nukleotide, Nukleoside, Peptide und Lipide) dieser genannten Wirkstoffe.
Biogene Wirkstoffe Unter biogenen Wirkstoffen sind beispielsweise Tocopherol, Tocopherolacetat, Tocopherol- palmitat, Ascorbinsäure, (Desoxy) Ribonucleinsäure und deren Fragmentierungsprodukte, ss Glucane, Retinof, Bisabolol, Allantoin, Phytantriol, Panthenol, AHA-Säuren, Aminosäuren, Ceramide, Pseudoceramide, essentielle Öle, weitere Pflanzenextrakte, und Vitaminkomplexe zu verstehen.
Deodorantien und keimhemmende Mittel Kosmetische Deodorantien (Desodorantien) wirken Körpergerüchen entgegen, überdecken oder beseitigen sie. Körpergerüche entstehen durch die Einwirkung von Hautbakterien auf apokrinen Schweiss, wobei unangenehm riechende Abbauprodukte gebildet werden. Dementsprechend enthalten Deodorantien Wirkstoffe, die als keimhemmende Mittel, Enzyminhibitoren, Geruchsabsorber oder Geruchsüberdecker fungieren.
> Keimhemmende Mittel
Als keimhemmende Mittel sind grundsätzlich alle gegen grampositive Bakterien wirksa men Stoffe geeignet, wie z. B. 4-Hydroxybenzoesäure und ihre Salze und Ester, N- (4- Chlorphenyl)-N'- (3, 4 dichlorphenyl) harnstoff, 2,4,4'-Trichlor-2'-hydroxy-diphenylether (Triclosan), 4-Chlor-3, 5-dimethyl-phenol, 2,2'-Methylen-bis (6-brom-4-chlorphenol), 3 Methyl-4- (1-methylethyl)-phenol, 2-Benzyl-4-chlorphenol, 3- (4-Chlorphenoxy)-1, 2 propandiol, 3-Iod-2-propinylbutylcarbamat, Chlorhexidin, 3,4,4'-Trichlorcarbanilid (TTC), antibakterielle Riechstoffe, Thymol, Thymianöl, Eugenol, Nelkenöl, Menthol, Min zöl, Farnesol,
Phenoxyethanol, Glycerinmonocaprinat, Glycerinmonocaprylat, Glycerin monolaurat (GML), Diglycerinmonocaprinat (DMC), Salicylsäure-N-alkylamide wie z. B.
Salicylsäure-n-octylamid oder Salicylsäure-n-decylamid.
> Enzyminhibitoren
Als Enzyminhibitoren sind beispielsweise Esteraseinhibitoren geeignet. Hierbei handelt es sich vorzugsweise um Trialkylcitrate wie Trimethylcitrat, Tripropylcitrat, Triisopropyl citrat, Tributylcitrat und insbesondere Triethylcitrat (Hydagenq3 CAT). Die Stoffe in hibieren die Enzymaktivität und reduzieren dadurch die Geruchsbildung.
Weitere Stoffe, die als Esteraseinhibitoren in Betracht kommen, sind Sterolsulfate oder-phosphate, wie beispielsweise Lanosterin-, Cholesterin-, Campesterin-, Stigmasterin-und Sitosterin sulfat bzw-phosphat, Dicarbonsäuren und deren Ester, wie beispielsweise Glutarsäure,
Glutarsäuremonoethylester, Glutarsäurediethylester, Adipinsäure, Adipinsäuremono ethylester, Adipinsäurediethylester, Malonsäure und Malonsäurediethylester, Hydroxy carbonsäuren und deren Ester wie beispielsweise Citronensäure, Äpfelsäure, Weinsäure oder Weinsäurediethylester, sowie Zinkglycinat.
> Geruchsabsorber
Als Geruchsabsorber eignen sich Stoffe, die geruchsbildende Verbindungen aufnehmen und weitgehend festhalten können. Sie senken den Partialdruck der einzelnen Kompo nenten und verringern so auch ihre Ausbreitungsgeschwindigkeit. Wichtig ist, dass dabei
Parfums unbeeinträchtigt bleiben müssen. Geruchsabsorber haben keine Wirksamkeit gegen Bakterien. Sie enthalten beispielsweise als Hauptbestandteil ein komplexes Zink salz der Ricinolsäure oder spezielle, weitgehend geruchsneutrale Duftstoffe, die dem
Fachmann als"Fixateure"bekannt sind, wie z. B. Extrakte von Labdanum bzw. Styrax oder bestimmte Abietinsäurederivate.
Als Geruchsüberdecker fungieren Riechstoffe oder
Parfümöle, die zusätzlich zu ihrer Funktion als Geruchsüberdecker den Deodorantien ihre jeweilige Duftnote verleihen. Als Parfümöle seien beispielsweise genannt Gemische aus natürlichen und synthetischen Riechstoffen. Natürliche Riechstoffe sind Extrakte von
Blüten, Stengeln und Blättern, Früchten, Fruchtschalen, Wurzeln, Hölzern, Kräutern und
Gräsern, Nadeln und Zweigen sowie Harzen und Balsamen. Weiterhin kommen tierische
Rohstoffe in Frage, wie beispielsweise Zibet und Castoreum. Typische synthetische
Riechstoffverbindungen sind Produkte vom Typ der Ester, Ether, Aldehyde, Ketone, Al kohole und Kohlenwasserstoffe. Riechstoffverbindungen vom Typ der Ester sind z. B.
Benzylacetat, p-tert.-Butylcyclohexylacetat, Linalylacetat, Phenylethylacetat, Linalylben zoat, Benzylformiat, Allylcyclohexylpropionat, Styrallylpropionat und Benzylsalicylat. Zu den Ethern zählen beispielsweise Benzylethylether, zu den Aldehyden z. B. die linearen
Alkanale mit 8 bis 18 Kohlenstoffatomen, Citral, Citronellal, Citronellyloxyacetaldehyd,
Cyclamenaldehyd, Hydroxycitronellal, Lilial und Bourgeonal, zu den Ketonen z. B. die Jo none und Methylcedrylketon, zu den Alkoholen Anethol, Citronellol, Eugenol, Isoeugenol,
Geraniol, Linalool, Phenylethylalkohol und Terpineol, zu den Kohlenwasserstoffen gehö ren hauptsächlich die Terpene und Balsame. Bevorzugt werden jedoch Mischungen ver schiedener Riechstoffe verwendet, die gemeinsam eine ansprechende Duftnote erzeu gen.
Auch ätherische Öle geringerer Flüchtigkeit, die meist als Aromakomponenten ver wendet werden, eignen sich als Parfümöle, z. B. Salbeiöl, Kamillenöl, Nelkenöl, Melissen- öl, Minzenöl, Zimtblätteröl, Lindenblütenöl, Wacholderbeerenöl, Vetiveröl, Olibanöl, Gal banumöl, Labdanumöl und Lavandinöl. Vorzugsweise werden Bergamotteöl, Dihydromyrcenol, Lilial, Lyral, Citronellol, Phenylethylalkohol, a-Hexylzimtaldehyd, Geraniol, Benzylaceton, Cyclamenaldehyd, Linalool, Boisambrene Forte, Ambroxan, Indol, Hedione, Sandelice, Citronenöl, Mandarinenöl, Orangenöl, Allylamylglycolat, Cyclovertal, La vandinöl, Muskateller Salbeiöl, ss-Damascone, Geraniumöl Bourbon, Cyclohexylsalicylat, Vertofix Coeur, Iso-E-Super, Fixolide NP,
Evernyl, Iraldein gamma, Phenylessigsäure, Geranylacetat, Benzylacetat, Rosenoxid, Romilat, Irotyl und Floramat allein oder in Mischungen, eingesetzt.
Antitranspirantien Antitranspirantien (Antiperspirantien) reduzieren durch Beeinflussung der Aktivität der ekkrinen Schweissdrüsen die Schweissbildung, und wirken somit Achselnässe und Körpergeruch entgegen. Wässrige oder wasserfreie Formulierungen von Antitranspirantien enthalten typischerweise folgende Inhaltsstoffe : > adstringierende Wirkstoffe, > Ölkomponenten, > nichtionische Emulgatoren, > Coemulgatoren, > Konsistenzgeber, > Hilfsstoffe wie z. B. Verdicker oder Komplexierungsmittel und/oder > nichtwässrige Lösungsmittel wie z. B. Ethanol, Propylenglykol und/oder Glycerin.
Als adstringierende Antitranspirant-Wirkstoffe eignen sich vor allem Salze des Aluminiums, Zirkoniums oder des Zinks. Solche geeigneten antihydrotisch wirksamen Wirkstoffe sind z. B. Aluminiumchlorid, Aluminiumchlorhydrat, Aluminiumdichlorhydrat, Aluminium sesquichlorhydrat und deren Komplexverbindungen z. B. mit Propylenglycol-t, 2. Aluminiumhydroxyallantoinat, Aluminiumchloridtartrat, Aluminium-Zirkonium-Trichlorohydrat, Aluminium-Zirko-nium-tetrachlorohydrat, Aluminium-Zirkonium-pentachlorohydrat und deren Komplexverbindungen z. B. mit Aminosäuren wie Glycin. Daneben können in Antitranspirantien übliche öllösliche und wasserlösliche Hilfsmittel in geringeren Mengen enthalten sein. Solche öllöslichen Hilfsmittel können z.
B. sein : > entzündungshemmende, hautschützende oder wohlriechende ätherische Öle, > synthetische hautschützende Wirkstoffe und/oder > öllösliche Parfümöle.
Übliche wasserlösliche Zusätze sind z. B. Konservierungsmittel, wasserlösliche Duftstoffe, pH Wert-Stellmittel, z. B. Puffergemische, wasserlösliche Verdickungsmittel, z. B. wasserlösliche natürliche oder synthetische Polymere wie z. B. Xanthan-Gum, Hydroxyethylcellulose, Polyvinylpyrrolidon oder hochmolekulare Polyethylenoxide.
Filmbildner Gebräuchliche Filmbildner sind beispielsweise Chitosan, mikrokristallines Chitosan, quaterniertes Chitosan, Polyvinylpyrrolidon, Vinylpyrrolidon-Vinylacetat-Copolymerisate, Polymere der Acrylsäurereihe, quaternäre Cellulose-Derivate, Kollagen, Hyaluronsäure bzw. deren Salze und ähnliche Verbindungen.
Antischuppenwirkstoffe Als Antischuppenwirkstoffe kommen Pirocton Olamin (1-Hydroxy-4-methyl-6- (2, 4,4 trimythylpentyl)-2- (lH)-pyridinonmonoethanolaminsalz), Baypival (D (Climbazole), Ketoconazoll, (4-Acetyl-1- {-4- [2- (2. 4-dichlorphenyl) r-2- (lH-imidazol-1-yimethyl)-1, 3-dioxylan-c-4- ylmethoxyphenyllpiperazin, Ketoconazol, Elubiol, Selendisulfid, Schwefel kolloidal, Schwefel- polyehtylenglykolsorbitanmonooleat, Schwefelrizinolpolyehtoxylat, Schwfel-teer Destillate, Salicylsäure (bzw.
in Kombination mit Hexachlorophen), Undexylensäure Monoethanolamid Sulfosuccinat Na-Salz, Lamepone UD (Protein-Undecylensäurekondensat), Zinkpyrithion, Aluminiumpyrithion und Magnesiumpyrithion/Dipyrithion-Magnesiumsulfat in Frage.
Quellmittel Als Quellmittel für wässrige Phasen können Montmorillonite, Clay Mineralstoffe, Pemulen sowie alkylmodifizierte Carbopoltypen (Goodrich) dienen. Weitere geeignete Polymere bzw.
Quellmittel können der Übersicht von R. Lochhead in Cosm. Toil. 108,95 (1993) entnommen werden.
Insekten-Repellentien Als Insekten-Repellentien kommen N, N-Diethyl-m-toluamid, 1, 2-Pentandiol oder Ethyl Buty lacetylaminopropionate in Frage.
Selbstbräuner und Depigmentierungsmittel Als Selbstbräuner eignet sich Dihydroxyaceton. Als Tyrosinhinbitoren, die die Bildung von Melanin verhindern und Anwendung in Depigmentierungsmitteln finden, kommen beispielsweise Arbutin, Ferulasäure, Kojisäure, Cumarinsäure und Ascorbinsäure (Vitamin C) in Frage.
Hydrotrope Zur Verbesserung des Fliessverhaltens können ferner Hydrotrope, wie beispielsweise Ethanol, Isopropylalkohol, oder Polyole eingesetzt werden. Polyole, die hier in Betracht kommen, besitzen vorzugsweise 2 bis 15 Kohlenstoffatome und mindestens zwei Hydroxylgruppen. Die Polyole können noch weitere funktionelle Gruppen, insbesondere Aminogruppen, enthalten bzw. mit Stickstoff modifiziert sein.
Typische Beispiele sind > Glycerin ; > Alkylenglycole, wie beispielsweise Ethylenglycol, Diethylenglycol, Propylenglycol, Buty lenglycol, Hexylenglycol sowie Polyethylenglycole mit einem durchschnittlichen Moleku largewicht von 100 bis 1. 000 Dalton ; > technische Oligoglyceringemische mit einem Eigenkondensationsgrad von 1,5 bis 10 wie etwa technische Diglyceringemische mit einem Diglyceringehalt von 40 bis 50 Gew.-% ; > Methyolverbindungen, wie insbesondere Trimethylolethan, Trimethylolpropan, Trimethy lolbutan, Pentaerythrit und Dipentaerythrit ;
> Niedrigalkylglucoside, insbesondere solche mit 1 bis 8 Kohlenstoffen im Alkylrest, wie beispielsweise Methyl-und Butylglucosid ;
Zuckeralkohole mit 5 bis 12 Kohlenstoffatomen, wie beispielsweise Sorbit oder Mannit, > Zucker mit 5 bis 12 Kohlenstoffatomen, wie beispielsweise Glucose oder Saccharose ; > Aminozucker, wie beispielsweise Glucamin ; > Dialkoholamine, wie Diethanolamin oder 2-Amino-1, 3-propandiol.
Konservierungsmittel Als Konservierungsmittel eignen sich beispielsweise Phenoxyethanol, Formaldehydlösung, Parabene, Pentandiol oder Sorbinsäure sowie die unter der Bezeichnung Surfacine@ bekannten Silberkomplexe und die in Anlage 6, Teil A und B der Kosmetikverordnung aufgeführten weiteren Stoffklassen.
Parfümöle und Aromen Als Parfümöle seien genannt Gemische aus natürlichen und synthetischen Riechstoffen. Natürliche Riechstoffe sind Extrakte von Blüten (Lilie, Lavendel, Rosen, Jasmin, Neroli, Ylang Ylang), Stengeln und Blättern (Geranium, Patchouli, Petitgrain), Früchten (Anis, Koriander, Kümmel, Wacholder), Fruchtschalen (Bergamotte, Zitrone, Orangen), Wurzeln (Macis, Angelica, Sellerie, Kardamon, Costus, Iris, Camus), Hölzern (Pinien-, Sande-, Guajak-, Zedern-, Rosenholz), Kräutern und Gräsern (Estragon, Lemongras, Salbei, Thymian), Nadeln und Zweigen (Fichte, Tanne, Kiefer, Latschen), Harzen und Balsamen (Galbanum, Elemi, Benzoe, Myrrhe, Olibanum, Opoponax). Weiterhin kommen tierische Rohstoffe in Frage, wie beispielsweise Zibet und Castoreum.
Typische synthetische Riechstoffverbindungen sind Produkte vom Typ der Ester, Ether, Aldehyde, Ketone, Alkohole und Kohlenwasserstoffe. Riechstoffverbindungen vom Typ der Ester sind z. B. Benzylacetat, Phenoxyethylisobutyrat, p-tert. Butylcyclohexylacetat, Linalylacetat, Dimethylbenzylcarbinylacetat, Phenylethylacetat, Linalylbenzoat, Benzylformiat, Ethylmethylphenylglycinat, Allylcyclohexylpropionat, Styrallylpropi- onat und Benzylsalicylat. Zu den Ethern zählen beispielsweise Benzylethylether, zu den Aldehyden z. B. die linearen Alkanale mit 8 bis 18 Kohlenstoffatomen, Citral, Citronellal, Citronel- lyloxyacetaldehyd, Cyclamenaldehyd, Hydroxycitronellal, Lilial und Bourgeonal, zu den Ketonen z.
B. die Jonone, a-Isomethylionon und Methylcedrylketon, zu den Alkoholen Anethol, Citronellol, Eugenol, Isoeugenol, Geraniol, Linalool, Phenylethylalkohol und Terpineol, zu den Kohlenwasserstoffen gehören hauptsächlich die Terpene und Balsame. Bevorzugt werden jedoch Mischungen verschiedener Riechstoffe verwendet, die gemeinsam eine ansprechende Duftnote erzeugen. Auch ätherische Öle geringerer Flüchtigkeit, die meist als Aromakomponenten verwendet werden, eignen sich als Parfümöle, z. B. Salbeiöl, Kamillenöl, Nelkenöl, Melissenöl, Minzenöl, Zimtblätteröl, Lindenblütenöl, Wacholderbeerenöl, Vetiveröl, Olibanöl, Galbanumöl, Labolanumöl und Lavandinöl.
Vorzugsweise werden Bergamotteöl, Dihydromyrcenol, Lilial, Lyral, Citronellol, Phenylethylalkohol, a-Hexylzimtaldehyd, Geraniol, Benzylaceton, Cyclamenaldehyd, Linalool, Boisambrene Forte, Ambroxan, Indol, Hedione, Sandelice, Citronenöl, Mandarinenöl, Orangenöl, Allylamylglycolat, Cyclovertal, Lavandinöl, Muskateller Salbeiöl, ss-Damascone, Geraniumöl Bourbon, Cyclohexylsalicylat, Vertofix Coeur, Iso-E-Super, Fixolide NP, Evernyl, Iraldein gamma, Phenylessigsäure, Geranylacetat, Benzyacetat, Rosenoxid, Romililat, Irotyl und Floramat allein oder in Mischungen, eingesetzt.
Als Aromen kommen beispielsweise Pfefferminzöl, Krauseminzöl, Anisöl, Sternanisöl, Küm melöl, Eukalyptusöl, Fenchelöl, Citronenöl, Wintergrünöl, Nelkenöl, Menthol und dergleichen in Frage.
Farbstoffe Als Farbstoffe können die für kosmetische Zwecke geeigneten und zugelassenen Substanzen verwendet werden, wie sie beispielsweise in der Publikation"Kosmetische Färbemittel" der Farbstoffkommission der Deutschen Forschungsgemeinschaft, Verlag Chemie, Weinheim, 1984, S. 81-106 zusammengestellt sind. Beispiele sind Kochenillerot A (C. I. 16255), Patentblau V (C. I. 42051), Indigotin (C. I. 73015), Chlorophyllin (C. I. 75810), Chi nolingelb (C. I. 47005), Titandioxid (C. I. 77891), Indanthrenblau RS (C. I. 69800) und Krapplack (C. I. 58000). Als Lumineszenzfarbstoff kann auch Luminol enthalten sein. Diese Farbstoffe werden üblicherweise in Konzentrationen von 0,001 bis 0,1 Gew.-%, bezogen auf die gesamte Mischung, eingesetzt.
Der Gesamtanteil der Hilfs-und Zusatzstoffe kann 1 bis 50, vorzugsweise 5 bis 40 Gew.-%- bezogen auf die Mittel-betragen. Die Herstellung der Mittel kann durch übliche Kalt-oder Heissprozesse erfolgen ; vorzugsweise arbeitet man nach der Phaseninversionstemperatur Methode.
Beispiele Beispiel 1 : 30 g getrocknete Blätter oder Stämme von Myrothamnus flabellifolia wurden in einem Mörser grob zerstossen, dann in einen Glasreaktor überführt und mit 300 ml destil- liertem Wasser aufgegossen. Der Aufguss wurde auf ca. 80 C erhitzt und unter Rühren über einen Zeitraum von 1 h bei dieser Temperatur extrahiert. Anschliessend wurde die Mischung auf 20 C abgekühlt und 15 min bei einer Geschwindigkeit von 5000 g zentrifugiert. Die überstehende Flüssigkeit wurde durch Filtration (Maschenweite des Filters 0,45 um) vom Rückstand getrennt, wobei 190 ml Extrakt erhalten wurden, welcher einen Trockenrückstand von 1,6 Gew.-% aufwies.
Nach Spühtrocknung wurde ein Pulver erhalten, wobei die Ausbeute 9,1 Gew.-% bezogen auf das Trockengewicht betrug.
Beispiel 2 : Beispiel 1 wurde wiederholt, die Extraktion jedoch mit einer Methanol/Wasser- Mischung (1 : 1) durchgeführt. Nach Sprühtrocknung wurde ein Pulver erhalten, wobei die Ausbeute 18,5 Gew.-% bezogen auf das Trockengewicht betrug.
Beispiel 3 : Beispiel 1 wurde unter Einsatz von Blättern von Spirobolus cubensis (Hitchcock) wiederholt. Es wurde ein Pulver erhalten, wobei die Ausbeute rund 10 Gew.-% bezogen auf das Trockengewicht betrug.
Beispiel 4 : Beispiel 1 wurde unter Einsatz von Blättern von Selaginella lepidophylla wiederholt. Es wurde ein Pulver erhalten, wobei die Ausbeute rund 10 Gew.-% bezogen auf das Trockengewicht betrug.
Beispiel 5 : Beispiel 1 wurde unter Einsatz von Blättern von Xerophyta retinervis wiederholt.
Es wurde ein Pulver erhalten, wobei die Ausbeute rund 10 Gew.-% bezogen auf das Trockengewicht betrug.
Beispiel 6 : Beispiel 1 wurde wiederholt, die Extraktion jedoch mit Blättern von Craterostigma plantigineum mit 300 mi 96 Gew.-% igen Ethanols durchgeführt. Die Blätter wurden wie oben beschrieben zweimal extrahiert und die Extrakte vereinigt. Anschliessend wurde zunächst der Alkohol bei 45 C unter vermindertem Druck entfernt und dann der Rückstand bei 50 C getrocknet. Es wurde ein Pulver erhalten, wobei die Ausbeute bezogen auf das Trockengewicht der eingesetzten Blätter rund 20 Gew.-% betrug.
Beispiel 7 : 1 kg frische Bäckerhefe Saccharomyces cerevisiae wurden in 2 Liter Wasser mit 50mM NaC suspendiert. Der pH-Wert der Lösung wurde mit 2N NaOH-Lösung auf 7, 5 einge stellt, 15 min bei 100 C erhitzt und anschliessend gekühlt. Mit einem diskontinuierlichen Hochdruckhomogenisator wurden die Zellen bei 800 bar zerstört. Der pH-Wert wurde mit 2N Schwefelsäure auf 4 eingestellt, die Suspension erneut 15 min auf 100 C erhitzt und abgekühlt. Unlösliche Teile wurden durch Zentrifugation über 30 min bei 5600 g abgetrennt und die überstehende Lösung wurde filtriert. Die erhaltene opaleszierende Lösung wurde getrocknet und man erhielt 4,3 % Trockenprodukt.
Beispiel 8 : Zellschutzwirkung gegen UVA an in vitro gezüchteten menschlichen Fibroblasten Hintergrund : UVA-Strahlen dringen bis in die Dermis ein, wo sie zu Oxidationsstress führen, was durch eine Lipoperoxidation der Zytoplasmamembranen nachgewiesen wird.
Die Lipoperoxide werden zu Malonaldialdehyd abgebaut, der viele biologische Moleküle wie Proteine und Nukleinbasen vernetzen wird (Enzymhemmung bzw. Mutagenese).
Methode : Zur Durchführung dieser Tests wurde ein definiertes Kulturmedium (DMEM) mit den Fibroblasten mit fötalem Kälberserum beimpft und der Pflanzenextrakt (in dem definierten Medium mit 10 % Fötalem Kälberserum) 72 Stunden nach dem Beimpfen zugegeben. Die Inkubation erfolgte bei 37 C und einem CO2-Gehalt von 5 %.
Nach 48 stündiger Inkubation bei 37 C und einem C02-Gehalt von 5 % wurde das Kulturmedium durch Saline-Lösung (physiologische NaCI-Lösung) ersetzt und die Fibroblasten wurden mit einer UVA-Dosis bestrahlt (365 nm, 20 J/cm2 ; Röhren : MAZDA FLUOR TFWN40).
Nach der Beendigung der Bestrahlung wurde der MDA-Spiegel (Malonaldialdehyd-Spiegel) in der überstehenden Natriumchlorid-Lösung quantitativ durch Reaktion mit Thiobarbitursäure bestimmt. Der Gehalt an Proteinen wurde nach der Methode von Bradford mit einer Coomassie-Brilliant-Blue-Anfärbung bestimmt (Bradford ; Analytical biochem., 72 ; 248-254 ; 1976).
EMI26.1
<tb>
<SEP> Konzentration <SEP> Gehalt <SEP> an <SEP> MDA <SEP> Gehalt <SEP> an <SEP> Proteinen
<tb> <SEP> Gew.-% <SEP> [% <SEP> versus <SEP> Kontrolle <SEP> [% <SEP> versus <SEP> Kontrolle
<tb> <SEP> Extrakt <SEP> nach <SEP> Beispiel <SEP> 1 <SEP> Extrakt <SEP> nach <SEP> Beispiel <SEP> 1
<tb> <SEP> Kontrolle <SEP> ohne <SEP> UV0100
<tb> <SEP> UVA <SEP> (365 <SEP> nm) <SEP> 100 <SEP> 103 <SEP> (7)
<tb> <SEP> UVA <SEP> + <SEP> Vitamin <SEP> E <SEP> 31 <SEP> (4) <SEP> 102 <SEP> (11)
<tb> UVA <SEP> + <SEP> Extrakt <SEP> 0, <SEP> 1% <SEP> 91 <SEP> (5) <SEP> 101 <SEP> (16)
<tb> UVA <SEP> + <SEP> Extrakt <SEP> 0,3 <SEP> % <SEP> 67 <SEP> (6) <SEP> 100 <SEP> (17)
<tb> Tabelle 1 Gehalt an MDA und an Proteinen zur Bestimmung der Zellschutzwirkung gegen UVA- (in Klammern findet sich die Standardabweichung) Die Ergebnisse aus der Tabelle zeigen,
dass die Extrakte der Pflanze Myrothamnus flabellifolia bei einer Konzentration von 0,3 Gew.-% signifikant den Grad an MDA in humanen Fibroblasten, welcher durch UVA-Strahlen induziert wird, reduzieren. Diese Ergebnisse zeigen eine hohe Kapazität schädliche Effekte eines oxidativen Stresses auf der Haut zu reduzieren.
Der Gehalt an Proteinen verdeutlicht nochmals den nichttoxischen Effekt des Extraktes.
Beispiel 9 : Zellschutzwirkung gegen UVB an in vitro gezüchteten menschlichen Keratinozyten Methode : Der Effekt von UVB-Strahlung wurde an Keratinocyten in vitro untersucht indem die Freisetzung des Cytoplasaenzyms LDH (Lactat Dehydrogenase) bestimmt wurde. Dieses Enzym dient als Marker für eine Zellschädigung.
Zur Durchführung der Tests wurde ein definiertes Medium (DMEM), das fötales Kälberserum enthält, mit den Keratinozyten beimpft und der Pflanzenextrakt (mit Saline-Lösung verdünnt) 72 Stunden nach dem Beimpfen zugegeben.
Die Keratinozyten wurden sodann mit einer UVB-Dosis bestrahlt (50 mJ/cm2-Röhren : DUKE FL40E).
Nach weiterer 1 tägiger Inkubation bei 37 C und bei 5 % C02 wurde der LDH-Gehalt im Überstand bestimmt. Der Gehalt von LDH- (Lactatdehydrogenase) wurde spectrophotometrisch durch Bestimmung des NADH-Gehaltes während der LDH-katalysierten Umwandlung von Pyruvate zu Lactat nach der Methode von Bonnekoh bestimmt. (Bonnekoh B et al. ; Dermatol. Research ; 282 ; 325-329 ; 1990).
Die Anzahl adhärenter Keratinozyten wurde mit einem DNA-essay basierend auf eine Fluo- reszensmessung von Fluorochrom welches an zellulärem DNA bindet nach der Methode von Desaufniers bestimmt. (Desaulniers D, et ai. ; Toxic). in vitro ; 12 ; 409-422 ; 1998) einem Par tikeizähigerät bestimmt. Der Test wurde vergleichend mit einem Standard Antiinflammatorischen Mittel, Acetylsalicylsäure.
EMI27.1
<SEP> Extrakt <SEP> nach <SEP> Beispiel <SEP> 1 <SEP> [Gew.-%] <SEP> Anzahl <SEP> Keratinocyten <SEP> Gehalt <SEP> an <SEP> freigesetzte <SEP> LDH
<tb> <SEP> Kontrolle <SEP> ohne <SEP> UV <SEP> 100 <SEP> 0
<tb> <SEP> UVB <SEP> 315 <SEP> nu <SEP> 25 <SEP> (3) <SEP> 100
<tb> UVB <SEP> + <SEP> Acetylsalicylsäure <SEP> (0, <SEP> 03 <SEP> %) <SEP> 76 <SEP> (5) <SEP> 3 <SEP> (2)
<tb> <SEP> UVB <SEP> + <SEP> Extrakt <SEP> 0, <SEP> 1 <SEP> % <SEP> 27 <SEP> 4 <SEP> 91 <SEP> 8
<tb> <SEP> UVB <SEP> + <SEP> Extrakt <SEP> 0,3 <SEP> % <SEP> 40 <SEP> (7) <SEP> 57 <SEP> (20
<tb> Tabelle 2 Gehalt an freigesetzte LDH zur Bestimmung der Zellschutzwirkung gegen UVB- (in Klammern findet sich die Standardabweichung) Die Ergebnisse dieser Tests belegen,
dass die Extrakte den Effekt von UVB-Strahlung auf die Anzahl an Keratinocyten und auf den Gehalt an freigesetzte LDH bei einer Konzentration von 0,3 Gew.-% positiv beeinflussen. Die beschriebenen Extrakte zeigen demnach die Fähigkeit, die durch UVB-Strahlung hervorgerufene Schädigung an Zellmembranen zu reduzieren.
Beispiel 10 : Zellschutz negen Hitzeschock an humanen Fibroblasten Der Hitzeschock an humanen Fibroblasten wurde induziert durch die Erhöhung der Inkubationstemperatur von 37 C auf 45 C für zwei Stunden. Die Anzahl an lebenden gestressten Zellen wurde bestimmt durch den Gehalt an zellulärem Adenosintriphosphate (ATP) und am Gehalt an Lactatdehydrogenase (LDH). Der ATP-Gehalt ist ein gut bekannter Marker zellulärer Lebensfähigkeit und ein veränderter Gehalt ist ein sehr sensibler Test für Cytotoxizität.
Der Gehalt wurde bestimmt nach der Methode von Vasseur (Vasseur P. et al. ; Enviromental Pollution ; 1 ; 167-175 ; 1980).
Die Freisetzung des hochmolekularen Cytoplasmaenzyms LDH ist ein Zeichen für eine Zellmembranschädigung und ist ein allgemeiner Marker für einen Zellschaden. Der Gehalt von LDH- (Lactatdehydrogenase) wurde spectrophotometrisch durch Bestimmung des NADH Gehaltes während der LDH-katalysierten Umwandlung von Pyruvate zu Lactat nach der Methode von Bonnekoh bestimmt. (Bonnekoh B et al. ; Dermatol. Research ; 282 ; 325-329 ; 1990).
Methode : Zur Durchführung dieser Tests wurde ein definiertes Kulturmedium (DMEM) mit den Fibroblasten mit fötalem Kälberserum beimpft und der Pflanzenextrakt bzw. die zu testenden Mischungen und Zubereitungen (in dem definierten Medium mit 10 % Fötalem Kälberserum) 72 Stunden nach dem Beimpfen zugegeben. Die Inkubation erfolgte bei 37 C und einem C02-Gehalt von 5 %.
Nach 48 stündiger Inkubation bei 37 C und einem C02-Gehalt von 5 % wurden die Zellen dem Hitzeschock ausgesetzt indem die Inkubationstemperatur für zwei Stunden von 37 C auf 45 C erhöht wurde. Es folgte eine erneute Inkubation von 24 Stunden bei 37 C und einem C02-Gehalt von 5 %.
Der Gehalt an ATP wurde verfolgt durch Bestimmung des Lichtanteils bei der enzymatischen Reaktion zwischen ATP und dem Komplex aus Luciferin/Luciferase.
Neben dem Extrakt aus Beispiel 1 wurde eine Mischung enthaltend Wasser, Glycerin, Trehalose, Polysaccharide aus Tamarindus indica Samen und Myrothamnus flabellifolia Extrakt und eine Zubereitung enthaltend Myrothamnus flabellifolia Extrakt nach Beispiel 1 und Hefe Extrakt nach Beispiel 7 im Verhältnis 1 : 1 bei einer Konzentration von 0,01 Gew.-% getestet.
EMI29.1
<SEP> Behandlung <SEP> Gehalt <SEP> an <SEP> ATP <SEP> [%] <SEP> Gehalt <SEP> an <SEP> freigesetztem <SEP> LDH <SEP> [%]
<tb> <SEP> Kontrolle <SEP> ohne <SEP> Hitzeschock <SEP> 100 <SEP> 0
<tb> <SEP> Kontrolle <SEP> mit <SEP> Hitzeschock <SEP> 17 <SEP> (5) <SEP> 100
<tb> <SEP> Extrakt <SEP> nach <SEP> Beispiel <SEP> 1 <SEP> mit <SEP> 0,3 <SEP> Gew.-% <SEP> + <SEP> Hitzeschock <SEP> 77 <SEP> (4) <SEP> 16 <SEP> (7)
<tb> <SEP> Genannte <SEP> Mischung <SEP> mit <SEP> 1 <SEP> Gew.-% <SEP> + <SEP> Hitzeschock <SEP> 40 <SEP> 18 <SEP> 50 <SEP> 13
<tb> Zubereitung <SEP> aus <SEP> Extrakt <SEP> nach <SEP> Beispiel <SEP> 1 <SEP> und <SEP> Beispiel <SEP> 7 <SEP> 74 <SEP> 8
<tb> <SEP> (Verhältnis <SEP> 1 <SEP> :
<SEP> 1)/0, <SEP> 01 <SEP> Gew-% <SEP> + <SEP> Hitzeschock
<tb> Tabelle 3 Gehalt an freigesetzter LDH und an freigesetztem ATP zur Bestimmung der Zellschutzwirkung gegen
Hitzeschock- (in Klammern findet sich die Standardabweichung) Der schädliche Effekt des Hitzeschocks auf humane Fibroblasten konnte gezeigt werden durch den verringerten Gehalt an ATP und den erhöhten Gehalt an freigesetzten LDH. Die Behandlung mit Myrothamnus flabellifolia Extrakt hat eine zelluläre Resistenz gegen Hitzeschock erbracht. Bei einer Konzentration von 0,3 Gew.-% konnte der cytotoxische Effekt von Hitzeschock, ermittelt durch den ATP-Gehalt und durch den Gehalt an freigesetztem LDH nahezu beseitigt werden.
Beispiel 11 : Zellschutz gegen Kälteschock an humanen Lymphzellen Die Lebensfähigkeit von gestressten Zellen wurde untersucht an humanen Lymphzellen durch einen Test mit Propidium iodid. Propidium iodid wird von intakten Zellen nicht in die Zelle aufgenommen d. h. es penetriert nicht durch die intakte Zellwand. Erst eine Zellwandschädigung erlaubt die Penetration des Fluoreszensmarkers in die Zelle. Dadurch werden zerstörte Zellen fluoreszierend und die Aufnahme des Markers kann quantifiziert werden durch Flusscytometrie (vgl. Lemaster JJ. et al. ; Nature ; 325 ; 78-81 ; 1987).
Methode : Die Lymphzellen wurden einen Tag in einem Standardmedium"RPMI 1640 complete"der Firma Sigma kultiviert. Anschliessend wurde das Standardwachstumsmedium durch ein Medium ersetzt, welches entweder als Kontrollmedium diente oder die zu testende Mischung gemäss Beispiel 10 enthaltend enthaltend Wasser, Glycerin, Trehalose, Polysaccharide aus Tamarindus indica Samen und Myrothamnus flabellifolia Extrakt enthielt und für einen weiteren Tag inkubiert.
Der Kälteschock wurde ausgelöst durch 15 minütiges tiefgefrieren bei-20 C. Die Testergebnisse wurden entweder nach einer 15 minütigen postschock-Inkubation bei +20 C oder nach 4 stündiger Inkubation bei 37 C durch Flusscytometrie nach der Methode von Lemaster bestimmt. Die Werte für Lymphzellen ohne Kälteschock und Zusatz der Mischung mit 0,1 Gew.-% wurden zu den jeweils gleichen Inkubationszeiten bestimmt, jedoch waren die Zellen keinem 15 minütigem Kälteschock ausgesetzt.
EMI30.1
Behandlung <SEP> Propium <SEP> iodid-positiv <SEP> Zellen <SEP> [%] <SEP> Propium <SEP> iodid-positiv <SEP> Zellen <SEP> [%]
<tb> <SEP> 15 <SEP> Minuten <SEP> nach <SEP> dem <SEP> Kälteschock <SEP> 4 <SEP> Stunden <SEP> nach <SEP> dem <SEP> Kälteschock
<tb> LyC <SEP> ohne <SEP> Kälteschock <SEP> 11, <SEP> 2 <SEP> (0,4) <SEP> 9,9 <SEP> (0,17)
<tb> LyC <SEP> + <SEP> Mischung <SEP> mit <SEP> 0, <SEP> 1 <SEP> Gew.-% <SEP> 12,4 <SEP> (0,23) <SEP> 6,7 <SEP> (0,17)
<tb> LyC <SEP> + <SEP> mit <SEP> Kälteschock <SEP> 15,2 <SEP> (0,57) <SEP> 24,3 <SEP> (6,75)
<tb> Lyc <SEP> C <SEP> + <SEP> Mischung <SEP> mit <SEP> 0,3 <SEP> Gew.-% <SEP> + <SEP> Kälteschock <SEP> 12 <SEP> (1,09) <SEP> 11,2 <SEP> (0,86)
<tb> LyC = Lymphzellen Tabelle 4 Gehalt an fluoreszierenden Zellen zur Bestimmung der Zellschutzwirkung gegen Kälteschock- (in
Klammern findet sich die Standardabweichung)
Eine 15-minütige Kälteschock-Periode zeigt nach einer 4 stündigen Inkubationszeit einen anstieg an zerstörten Zellen, die den Fluoreszenzmarker aufgenommen haben. Durch die Behandlung mit einer Mischung enthaltend Wasser, Glycerin, Trehalose, Polysaccharide aus Tamarindus indica Samen und Myrothamnus flabellifolia Extrakt konnte die Lebensfähigkeit der Lymphzellen nach einem Kälteschock signifikant erhöht werden.
Beispiel 12 : Zellschutz gegen osmotischen Stress an roten Blutkörperchen (E- rythrozyten) Die Resistenz gegen osmotischen Stress oder auch"osmotischen Schock"an der Membranstabilisierenden Aktivität wurde getestet on humanen roten Blutkörperchen indem man sie in Kontakt brachte mit einem hypo-osmotischen Medium.
Methode : Zunächst wurde ein Lösung aus gepufferter hypo-osmotischer Salzlösung enthaltend 0,24 g/1 NaC1 hergestellt und die roten Blutkörperchen in dieser Lösung für 60 min. bei Raumtemperatur inkubiert. Die zu testende Mischung enthaltend Wasser, Glycerin, Trehalose, Polysaccharide aus Tamarindus indica Samen und Myrothamnus flabellifolia Extrakt wurde inuntershciedlichen Konzentrationen zugesetzt. Zur Kontrolle wurden die Zellen ohne zu testende Mischung jedoch in der osmotischen Salzlösung inkubiert. Anschliessend wurden die Zellen bei 3000 rpm für 10 min. zentrifugiert. Die Intensität der eingesetzten Hämolyse (Austritt von Hämoglobin aus den Erythrozyten) wurde spektrophotometrisch bei einer optischen Dichte von 412 nm verfolgt.
EMI31.1
Behandlung <SEP> Intensität <SEP> an <SEP> freigesetztem <SEP> Hämoglobin
<tb> Kontrolle <SEP> mit <SEP> osmotischem <SEP> Schock <SEP> 100
<tb> Genannte <SEP> Mischung <SEP> mit <SEP> 1 <SEP> Gew.-% <SEP> + <SEP> osmotischem <SEP> Schock <SEP> 91 <SEP> (6)
<tb> Genannte <SEP> Mischung <SEP> mit <SEP> 3 <SEP> Gew.-% <SEP> + <SEP> osmotischem <SEP> Schock <SEP> 45 <SEP> (6)
<tb> Tabelle 5 Intensität an freigesetztem Hämoglobin zur Bestimmung der Zellschutzwirkung gegen osmotischen
Schock- (in Klammern findet sich die Standardabweichung) Die Test belegen eine zellschutzwirkende Aktivität der getesteten Mischung enthaltend Wasser, Glycerin, Trehalose, Polysaccharide aus Tamarindus indica Samen und Myrothamnus flabellifolia Extrakt gegen osmotischen Schock.
Diese Wirkung ist bei einer Konzentration von 3 Gew.-% der Lösung signifikant durch eine verminderte Freisetzung von Hämoglobin aus den gestressten Erythrozyten zu detektieren.
Beispiel 13 : Test zur Feuchtigkeitsregulierung der Haut Hintergrund : In der Epidermis menschlicher Haut findet sich die Hornschicht (das Stratum corneum). Das Stratum corneum ist ein dielektrisches Medium von geringer elektrischer Leitung. Der Wassergehalt führt zur erhöhten dielektrischen Leitfähigkeit und die Bestimmung der dielektrischen Leitfähigkeit des Stratum corneum kann somit als Mass für den Grad der Feuchtigkeit menschlicher Haut dienen. Die Erhöhung der dielektrischen Leitfähigkeit des Stratum corneum reflektiert einen erhöhten Feuchtigkeitsgrad der menschlichen Haut.
Methode : Proben von normaler Haut, erhalten aus der plastischen Chirurgie, wurden für diesen Test verwendet. Das Stratum corneum aus diesen Hautproben wurde in Kammern mit definierter relativer Feuchtigkeit (44 %, gesättigte Lösung von Kaliumcarbonat) gelagert und standardisiert. Jede Probe des Stratum corneums wurde unter vier Bedingungen vergleichend getestet.
1) ohne Behandlung ;
2) Behandlung mit Placebo ;
3) Behandlung mit einer Zubereitung die aus einem Hydrogel besteht (Hydrogel LS von der Firma Laboratoire Sérobiologique LS), enthaltend 1,125 Gew.-% My rothamnus flabellifolia Extrakt.
4) Behandlung mit einer Zubereitung die aus einem Hydrogel besteht (Hydrogel LS von der Firma Laboratoire Sérobiologique LS), enthaltend 3 Gew.-% einer Mi schung enthaltend Wasser, Glycerin, Trehalose, Polysaccharide aus Tamarindus indica Samen und Myrothamnus flabellifolia Extrakt.
Als Placebo diente das Hydrogel (Hydrogel LS der Firma Laboratoire Sérobiologique LS) ohne die beschriebene Zubereitung, also ohne Pflanzenextrakt.
Die feuchtigkeitsregulierende Aktivität der oben beschriebenen Zubereitung wurde bestimmt in prozentualer Erhöhung der Leitfähigkeit im Vergleich zur Placebo Behandlung.
Aus den Ergebnissen lässt sich eine Dosis-abhängige feuchtigkeitsregulierende Aktivität erkennen.
EMI32.1
<tb>
Art <SEP> der <SEP> Beharidlung <SEP> Vor <SEP> de <SEP> 30 <SEP> min <SEP> 1 <SEP> : <SEP> Stunde. <SEP> 2 <SEP> Stunden <SEP> 4 <SEP> Stunden <SEP> 6 <SEP> Stünden <SEP> 2 <SEP> Stünden
<tb> <SEP> Behändlung <SEP> =
<tb> Kontrolle <SEP> 22, <SEP> 5 <SEP> (4, <SEP> 4) <SEP> 22, <SEP> 1 <SEP> (2, <SEP> 7) <SEP> 21, <SEP> 9 <SEP> (3, <SEP> 8) <SEP> 23, <SEP> 9 <SEP> (4, <SEP> 4) <SEP> 20, <SEP> 3 <SEP> (3, <SEP> 3) <SEP> 22, <SEP> 9 <SEP> (3, <SEP> 9) <SEP> 20, <SEP> 0 <SEP> (3, <SEP> 0)
<tb> Kontro <SEP> ! <SEP> ie <SEP> 22,5 <SEP> (4,4) <SEP> 22,1 <SEP> (2,7) <SEP> 21,9 <SEP> (3,8) <SEP> 23,9 <SEP> (4,4) <SEP> 20,3 <SEP> (3,3) <SEP> 22,9 <SEP> (3,9) <SEP> 20,0 <SEP> (3,0)
<tb> Placebo <SEP> 23,7 <SEP> (1,8) <SEP> 59,1 <SEP> (2,4) <SEP> 41,3 <SEP> (2,7) <SEP> 34,9 <SEP> (2,1) <SEP> 33,6 <SEP> (2,4) <SEP> 33,0 <SEP> (3,0) <SEP> 32,0 <SEP> (1,7)
<tb> Behandlung <SEP> nach <SEP> 3)
<SEP> 22,9 <SEP> (1,6) <SEP> 82,4 <SEP> (11,9) <SEP> 50,7 <SEP> (2,8) <SEP> 40,1 <SEP> (3,0) <SEP> 35,1 <SEP> (2,5) <SEP> 32,6 <SEP> (2,4) <SEP> 31,8 <SEP> (1,8)
<tb> Behandlung <SEP> nach <SEP> 4) <SEP> 24,4 <SEP> (2,8) <SEP> 111, <SEP> 1 <SEP> (6,5) <SEP> 80,7 <SEP> (4,2) <SEP> 67,9 <SEP> (4,6) <SEP> 56,9 <SEP> (4,3) <SEP> 53,5 <SEP> (4,4) <SEP> 54,6 <SEP> (4,7)
<tb> Tabelle 1 Feuchtigkeitsregulierender Effekt, bestimmt durch Messung der dielektrischen Leitfähigkeit (in pS) ;
Mittelwert aus 18 Untersuchungen (in Klammern findet sich die Standardabweichung) Beispiel 14 : Zur Ermittlung der Polysaccharidzusammensetzung wurden die Extrakte gemäss Beispiele 1 und 2 einer Dünnschichtchromatographie unterworfen.
Lösungsmittel : Aceton-Butanol-Phosphatpuffer/pH=7 : 50 : 40 : 10 v/v) Anfärbung Nl- (naphtyl) ethylendiamine Dihydrochloride (100 C ; 10-15 min) Die Figur 1 zeigt das Chromatogramm zu Beispiel 14 Die Nummerierung unterhalb des Chromatogramms hat folgende Bedeutung : 1 Analytischer Extrakt von Myrothamnus flabellifolia 2 : Analytischer Extrakt von Myrothamnus flabellifolia 3 : Myrothamnus flabellifolia Extrakt gemäss Beispiel 1 bei 1 Gew.-% 4 : Myrothamnus flabellifolia Extrakt gemäss Beispiel 2 bei 1 Gew.-% 5 : Trehalose Standard 0.1 Gew.-% 6 :
Rhamnose Standard 0.1 Gew.-% 7 : Glucose Standard 0.1 Gew.-% Beispiel 15 : Zur Bestimmung der Radikalfänger wurden die Extrakte gemäss Beispiele 1 und 2 einer weiteren Dünnschichtchromatographie unterworfen.
Lösungsmittel : Toluol-Ethylacetat-Ameisensäure-Wasser, 46 : 84 : 24 : 15 v/v).
Anfärbung : Neu + PEG (Flavone), DMCA (Tannine, Anthocyane), 100 C ; 10-15 min.
Die Figur 2 zeigt das Chromatogramm zu Beispiel 15 und die Nummerierung unterhalb des Chromatogramms hat folgende Bedeutung : 1 : Myrothamnus flabellifolia Extrakt gemäss Beispiel 1 bei 1 Gew.-% 2 : Myrothamnus flabellifolia Extrakt gemäss Beispiel 2 bei 1 Gew.-% 3 : Analytischer Methanolextrakt 80 % v/v bei 7,5 % v/v gemäss Beispiel 1 4 : Analytischer Methanolextrakt 80 % v/v bei 7, 5 % v/v gemäss Beispiel 2 5 : Standardmischung : Rutin + Isoquercitrin 6 : Standardmischung : Quercetin + Quercetol Beispiele 16 und 17 :
In der folgenden Tabelle 7 sind zwei sogenannte"Überlebensfraktionen"wiedergegeben, die durch Ausmischen von aktiven Bestandteilen der erfindungsgemä ssen Extrakte hergestellt wurden. Die Herstellung erfolgte durch Vermischen der Xyloglucane, der Extrakte und des Glycerins bei 70 C ; die übrigen Bestandteile wurden später zugegeben.
Tabelle 7 Überlebensfraktionen
EMI33.1
Zusammensetzung <SEP> Bsp. <SEP> 16 <SEP> Bsp17
<tb> Tamarinden <SEP> Xyloglucane <SEP> 16,7 <SEP> 16 <SEP> 0
<tb> Extrakt <SEP> Bsp. <SEP> 1 <SEP> 37, <SEP> 5
<tb> Extrakt <SEP> Bsp. <SEP> 6-37, <SEP> 5
<tb> Glycerin <SEP> 40,0 <SEP> 40 <SEP> 0
<tb> Trehalose <SEP> 2, <SEP> 3 <SEP> 2, <SEP> 0
<tb> Konservierungsmittel <SEP> 3, <SEP> 5 <SEP> 3, <SEP> 5
<tb> Wasser <SEP> ad <SEP> 100
<tb> Aus den obigen Ergebnissen der Beispiele zur Aktivitätsbestimmung geht hervor, dass die untersuchten und geprüften Extrakte der Pflanze Myrothamnus flabellifolia folgende Fähigkeiten aufweisen : 1. Verringerung des durch die UVA-Strahlen an menschlichen Fibroblasten induzierten Lipo peroxidationsgrads ; 2.
Verringerung der durch UVB an menschlichen Keratinozyten induzierten Zellschadens ; 3. Zellschutzwirkung gegen Hitzeschock, Kälteschock und osmotischen Schock und damit eine Aktivität die haut gegen schädliche Umwelteinflüsse zu schützen.
4. eine Zubereitung, enthaltend Extrakte der Pflanze Myrothamnus flabellifolia zeigte deutli che feuchtigkeitsregulierende Fähigkeiten.
Tabelle 2 Kosmetische Zubereitungen (Wasser, Konservierungsmittel ad 100 Gew.-%)
EMI34.1
<tb> Zusammensetzung <SEP> (INCI) <SEP> 1 <SEP> 2 <SEP> 3 <SEP> 4 <SEP> 5 <SEP> 6
<tb> Emu) <SEP> gade@ <SEP> SE5, <SEP> 0 <SEP> 5,0 <SEP> 5,0 <SEP> 4, <SEP> 0 <SEP> - <SEP>
<tb> Glyceryl <SEP> Sterate <SEP> (and) <SEP> Ceteareth <SEP> 12/20 <SEP> (and) <SEP> Cetearyl <SEP> Alcohol
<tb> <SEP> (and)Cetyl <SEP> Palmitate
<tb> Eumulgin# <SEP> Bi <SEP> - <SEP> - <SEP> - <SEP> 1,0 <SEP> - <SEP>
<tb> Ceteareth-12
<tb> Lameform# <SEP> TGI <SEP> - <SEP> - <SEP> - <SEP> - <SEP> 4,0 <SEP>
<tb> Polyglyceryl-3 <SEP> Isostearate
<tb> Dehymuls# <SEP> PGPH-----4, <SEP> 0
<tb> Polyglyceryl-2 <SEP> Dipolyhydroxystearate
<tb> Monomulse <SEP> 90-018 <SEP> 2, <SEP> 0
<tb> Glyceryl <SEP> Oleate
<tb> Cetiol# <SEP> HE-----2,
<SEP> 0
<tb> PEG-7 <SEP> Glyceryl <SEP> Cocoate
<tb> Cetiol# <SEP> OE <SEP> - <SEP> - <SEP> - <SEP> - <SEP> 5, <SEP> 0 <SEP> 6,0
<tb> Dicaprylyl <SEP> Ether
<tb> Cetiol# <SEP> PGL <SEP> - <SEP> - <SEP> - <SEP> 3, <SEP> 0 <SEP> 10, <SEP> 0 <SEP> 9,0
<tb> Hexyldecanol <SEP> (and) <SEP> Hexyldecyl <SEP> Laurate
<tb> Cetiols <SEP> SN <SEP> 3,0 <SEP> 3,0 <SEP> 3,0 <SEP> - <SEP> - <SEP>
<tb> CetearylIsononanoate
<tb> Cetiole <SEP> V <SEP> 3,0 <SEP> 3,0 <SEP> 3,0
<tb> DecylOleate
<tb> Myritol# <SEP> 318---3, <SEP> 0 <SEP> 5,0 <SEP> 5,0
<tb> CocoCaprylate <SEP> Caprate
<tb> Bees <SEP> Wax <SEP> 7, <SEP> 0 <SEP> 5, <SEP> 0
<tb> Nutrilan@
<SEP> Elastin <SEP> E20 <SEP> 2,0 <SEP> 2,0---
<tb> HydrolyzedElastin
<tb> Extrakt <SEP> gemä# <SEP> Bsp. <SEP> 1 <SEP> 0,1 <SEP> - <SEP> - <SEP> - <SEP> - <SEP>
<tb> Extrakt <SEP> gemäss <SEP> Bs. <SEP> 2 <SEP> - <SEP> 0.1 <SEP> - <SEP> - <SEP> - <SEP>
<tb> Extrakt <SEP> emä# <SEP> Bsp. <SEP> 3 <SEP> - <SEP> - <SEP> 0,1 <SEP> - <SEP> - <SEP>
<tb> Extrakt <SEP> gemäss <SEP> Bsp. <SEP> 4 <SEP> - <SEP> - <SEP> - <SEP> 0,1 <SEP> - <SEP>
<tb> Extrakt <SEP> gemäss <SEP> Bsp. <SEP> 5----0 <SEP> 1
<tb> Extrakt <SEP> gemäss <SEP> Bs.
<SEP> 6 <SEP> - <SEP> - <SEP> - <SEP> - <SEP> - <SEP> 0,1
<tb> Nutrillan# <SEP> I-50 <SEP> - <SEP> - <SEP> 2,0 <SEP> - <SEP> - <SEP>
<tb> H <SEP> drol <SEP> zed <SEP> Colla <SEP> en
<tb> Gluadin# <SEP> AGP <SEP> - <SEP> - <SEP> - <SEP> 0,5 <SEP> - <SEP>
<tb> Hvdrolvzed <SEP> Wheat <SEP> Gluten
<tb> Gluadin# <SEP> WK <SEP> - <SEP> - <SEP> - <SEP> - <SEP> 0, <SEP> 5 <SEP> 0,5
<tb> Sodium <SEP> Cocoyl <SEP> Hydrolyzed <SEP> Wheat <SEP> Protein
<tb> Highcareen# <SEP> GS <SEP> 1,0 <SEP> 1,0 <SEP> 1,0 <SEP> 1,0 <SEP> 1,0 <SEP> 1,0
<tb> Betaglucan
<tb> Hydagen# <SEP> CMF <SEP> 1,0 <SEP> 1,0 <SEP> 1,0 <SEP> 1,0 <SEP> 1,0 <SEP> 1,0
<tb> Chitosan
<tb> Magnesium <SEP> Sulfate <SEP> Hepta <SEP> Hydrate <SEP> - <SEP> - <SEP> - <SEP> - <SEP> 1,0 <SEP> 1,0
<tb> Glycerin <SEP> (86 <SEP> Gew.-% <SEP> ig) <SEP> 3, <SEP> 0 <SEP> 3 <SEP> 0 <SEP> 3.0 <SEP> 5 <SEP> 0 <SEP> 5 <SEP> 0 <SEP> 3,
<SEP> 0
<tb> (1,2) Softcreme, (3,4) Feuchtigkeitsemulsion, (5,6) Nachtcreme Tabelle 2 Kosmetische Zubereitungen (Wasser, Konservierungsmittel ad 100 Gew.-%)-Fortsetzung
EMI35.1
Zusammensetzung <SEP> (INCI) <SEP> 7 <SEP> 8 <SEP> 9 <SEP> 10 <SEP> 11 <SEP> 12
<tb> Emu <SEP> ! <SEP> gade@
<SEP> SE5, <SEP> 0 <SEP> 5,0 <SEP> 5,0 <SEP> 4,0- Glyceryl <SEP> Sterate <SEP> (and) <SEP> Ceteareth <SEP> 12/20 <SEP> (and) <SEP> Cetearyl <SEP> Alcohol
<tb> <SEP> (and) <SEP> Cetyl <SEP> Palmitate
<tb> Eumulgin <SEP> B1---1, <SEP> 0- Ceteareth-12
<tb> Lameform# <SEP> TGI <SEP> - <SEP> - <SEP> - <SEP> - <SEP> 4,0 <SEP> Polyglyceryl-3 <SEP> Isostearate
<tb> Dehymuls# <SEP> PGPH <SEP> - <SEP> - <SEP> - <SEP> - <SEP> - <SEP> 4, <SEP> 0
<tb> Polyglyceryl-2 <SEP> Dipolyhydroxystearate
<tb> Monomuls# <SEP> 90-O <SEP> 18 <SEP> - <SEP> - <SEP> - <SEP> - <SEP> 2,0 <SEP> Glyceryl <SEP> Oleate
<tb> Cetiol# <SEP> HE <SEP> - <SEP> - <SEP> - <SEP> - <SEP> - <SEP> 2, <SEP> 0
<tb> PEG-7 <SEP> Glyceryl <SEP> Cocoate
<tb> Cetiol# <SEP> OE <SEP> - <SEP> - <SEP> - <SEP> - <SEP> 5, <SEP> 0 <SEP> 6,0
<tb> Dicaprylyl <SEP> Ether
<tb> Cetiol# <SEP> PGL <SEP> - <SEP> - <SEP> - <SEP> 3,
<SEP> 0 <SEP> 10,0 <SEP> 9,0
<tb> Hexyldecanol <SEP> (and) <SEP> Hexyldecyl <SEP> Laurate
<tb> étiole <SEP> SN <SEP> 3,0 <SEP> 3,0 <SEP> 3, <SEP> 0 <SEP> - <SEP> - <SEP> Cetearyl <SEP> Isononanoate
<tb> Cetiol# <SEP> V <SEP> 3,0 <SEP> 3,0 <SEP> 3,0-- Decyl <SEP> Oleate
<tb> Myritol# <SEP> 318 <SEP> - <SEP> - <SEP> - <SEP> 3, <SEP> 0 <SEP> 5,0 <SEP> 5,0
<tb> Coco <SEP> Caprylate <SEP> Caprate
<tb> Bees <SEP> Wax <SEP> - <SEP> - <SEP> - <SEP> - <SEP> 7,0 <SEP> 5 <SEP> 0
<tb> Nutrilan# <SEP> Elastin <SEP> E20 <SEP> 2,0 <SEP> 2, <SEP> 0 <SEP> - <SEP> - <SEP> - <SEP> H <SEP> drol <SEP> zed <SEP> Elastin
<tb> Zubereitung <SEP> gemäss <SEP> Bsp. <SEP> 16 <SEP> 0, <SEP> 1
<tb> Zubereitung <SEP> gemäss <SEP> Bsp.
<SEP> 17 <SEP> 1
<tb> Octulose <SEP> - <SEP> - <SEP> 0,1 <SEP> - <SEP> - <SEP> Arbutin <SEP> 0, <SEP> 1
<tb> Tamarinden <SEP> Xyloglucane <SEP> 0, <SEP> 1
<tb> Abszisinsäure0, <SEP> 1
<tb> Nutrilane <SEP> I-50 <SEP> 2, <SEP> 0
<tb> H <SEP> drol <SEP> zed <SEP> Colla <SEP> en
<tb> Gluadin@ <SEP> AGP-0, <SEP> 5 Hydrolyzed <SEP> Wheat <SEP> Gluten
<tb> Gluadin# <SEP> WK <SEP> - <SEP> - <SEP> - <SEP> - <SEP> 0, <SEP> 5 <SEP> 0,5
<tb> Sodium <SEP> Coco <SEP> Hydrolyzed <SEP> Wheat <SEP> Protein
<tb> Highcareen@ <SEP> GS <SEP> 1,0 <SEP> 1,0 <SEP> 1,0 <SEP> 1,0 <SEP> 1,0 <SEP> 1,0
<tb> Betaglucan
<tb> Hydagen@
<SEP> CMF <SEP> 1, <SEP> 0 <SEP> 1,0 <SEP> 1,0 <SEP> 1,0 <SEP> 1,0 <SEP> 1,0
<tb> Chitosan
<tb> Magnesium <SEP> Sulfate <SEP> Hepta <SEP> Hydrate <SEP> - <SEP> - <SEP> - <SEP> - <SEP> 1,0 <SEP> 1,0
<tb> Glycerin <SEP> (86 <SEP> Gew.-% <SEP> ig) <SEP> 3,0 <SEP> 3,0 <SEP> 3,0 <SEP> 5, <SEP> 0 <SEP> 5, <SEP> 0 <SEP> 3, <SEP> 0
<tb> (7,8) Softcreme, (9,10) Feuchtigkeitsemulsion, (11,12) Nachtcreme
Cosmetic and/or pharmaceutical preparations FIELD OF THE INVENTION The invention is in the field of cosmetics and relates to preparations with an effective content of extracts from resurrection plants and the use of the extracts and the active substances contained therein for the production of the preparations. PRIOR ART A major reason for skin aging is the loss of water in the upper layers of the epidermis and the formation of wrinkles associated therewith. Consequently, one of the approaches that cosmetic chemists are trying to use to counteract this phenomenon is to provide active ingredients that counteract environmental stress, dehydration and/or have a protective function so that cells are strengthened in their ongoing fight against environmental toxins. To do this, it is sometimes necessary to find unusual solutions. So it may be advisable to take important information from the knowledge that nature provides us and to transfer it for the respective needs. In the desert and arid zones of Africa, Asia and the Americas, a number of plant families have developed remarkable drought tolerance, allowing them to survive a 98% dehydration for a period of one year, only to thrive during the first monsoon rains within 24 hours to fully regenerate and form flowers. These poikilohydric representatives are summarized under the term "resurrection plants". These include mosses, lichens and ferns as well as a number of flowering plants (angiospermia), whose investigation revealed that the anatomical, biochemical and physiological adaptation is conditioned by the genome. Plants are subjected to two different stresses during the drought period, namely mechanical and oxidative stress. To avoid mechanical stress, resurrecting plants have a range of possibilities, one of which is the shrinking and splitting of vacuoles to lower the tension on the plasma membrane.Further effects are the increased incorporation of xyloglucans and methyl esters of pectin into the cell wall and the accumulation of osmolytes or osmo-regulating molecules (e.g. sucrose, mannitol, D-ononitol, trehaloses, fructans, amino acids etc.), which strengthens the cell wall and stops the production of toxic metabolites during dehydration. The interruption of cellular respiration and photosynthesis during the dry phase also leads to the formation of free radicals that can damage proteins, fats and nucleic acids. In order to prevent this, pigments of the anthocyanin type as well as special enzymes such as e.g. B. superoxide dismutase, glutathione reductase or ascorbate peroxidase, which intervene in the oxidative metabolism and are known as natural radical scavengers. The molecular basis of drought tolerance has not yet been fully elucidated. According to studies by D. Bartels at the University of Bonn, however, it seems to be clear that plant hormones such as abscisic acid (ABA) induce drought tolerance. In the meantime, a number of genes involved in both the drying and re-watering processes have also been isolated. Surprisingly, it was found that these are homologous to genes that are also found in the embryos of maturing seeds. For example, when drying out, the gene dsp-22 (desiccation stress protein) is activated, which stimulates the formation of a 21 KDa protein that accumulates in the chloroplasts [cf. D Bartels et al. EMBO Journal 11 (8), 2771 (1992)]. Furthermore, changes in sugar metabolism are important. For example, the leaves of non-stressed plants contain high concentrations of the unusual sugar 2-octulose, which is converted into sucrose during drying and probably has a protective function. With re-watering, the process is reversible. In this context, reference is also made to international patent application WO 97/42327 (University of Mexico), which reports the isolation of a gene from the resurrecting plant Selaginella lepidophylla which produces the sugar trehalose-6-phosphate. The object of the present invention was therefore to develop new active substances with which skin and hair can be protected from environmental influences in general and with which drying out of the skin can be prevented in particular. Furthermore, skin and hair should be given additional protection against osmotic and temperature-related shock. DESCRIPTION OF THE INVENTION The invention relates to cosmetic and/or pharmaceutical preparations containing extracts from resurrection plants. Surprisingly, it was found that the extracts—which are also referred to as “survival fractions”—or the active ingredients contained therein, which are mainly osmolytes (polysaccharides), terpenes, antioxidants and phytohormones as well as proteins, fulfill the task mentioned at the outset excellently. The extracts can be used as such, but it is also possible to isolate individual components from them and then to mix them in a different composition as required. Resurrection plants Resurrection plants do not represent a coherent group, but are found in very different plant families, of which the Poacea, Scrophulariacea, Myrothamnacea and/or Velloziacea families should be mentioned in particular. In a particular embodiment of the invention, the preparations contain extracts from resurrection plants selected from the group of the botanical families Poacea, Scrophulariacea, Myrothamnacea and/or Velloziacea. The most important representatives of the Poaceae include the genus Spirobolus, for example a grass that has a height reaches from 60 to 120 cm and develops pink flowers. It is widespread in the Americas, especially in Costa Rica, where the species Spirobolus cubensis, Spirobolus indicus, Spirobolus heterotepsis, Spirobolus capillaris, Spirobolus flexuosus, Spirobolus cryptandrus and Spirobolus airoides can be found. A particularly important example of a resurrecting plant in the Scrophulariaceae family is the genus Craterostigma, specifically the species Craterostigma plantigineum. From the Myrothamnaceae family, Myrothamnus niedenzu and Myrothamnus flabellifolia in particular should be mentioned; the Myrothamnus flabellifolia family, which was first described by Engler and Prantl in 1891, is particularly preferred for the purposes of the invention. This is a flat shrub that does not lose its leaves during the dry winter months, but rather clings tightly to the branches and comes alive again with the first summer rains. Essential components of the extracts from its leaves are arbutin, anthocyanins, polysaccharides (sucrose, glucose, trehalose, fructose, glucosyl-9-glycerol) and phytohormones (e.g. abscisic acid); continue to be terpenes such. B. Carvone and perillic alcohol found. Similar to octulose, arbutin also plays an important, albeit different, role in drought resistance because, as a source of hydroquinone, it prevents peroxidation of unsaturated lipids in cell membranes. Typical examples of resurgent plants from the VellozAacea family are members of the genus Xerophyta, such as Xerophyta retinervis and Xerophyta viscosa, native to Madagascar, which are flat-topped shrubs that develop showy purple flowers in the monsoon season. Also suitable according to the invention are extracts of the plants of Geni Boea, Ramonda, Habelea, Chamaegigas and Selaginella, such as. B. Selaginella lepidophylla and surviving fractions of protein-rich angiosperms or gymnosperms plants or microorganisms such. B. Saccharomyces cerevisiae. Extraction The extracts can be produced in a manner known per se, i. H. for example by aqueous, alcoholic or aqueous-alcoholic extract of the plants or plant parts. Regarding the appropriate traditional extraction methods such as maceration, remaceration, digestion, agitation maceration, vortex extraction, ultrasonic extraction, countercurrent extraction, percolation, repercolation, evacuation (extraction under reduced pressure), diacolation and solid-liquid extraction under continuous reflux , which is carried out in a Soxhlet extractor, all of which are familiar to the person skilled in the art and in principle all applicable, for the sake of simplicity, for example, refer to Hagers Handbuch der Pharmazeutischen Praxis, (5th edition, vol. 2, pp. 1026-1030, Springer Verlag , Berlin-Heidelberg-New-York 1991). The percolation method is advantageous for large-scale use. Fresh plants or parts of plants can be used as the starting material, but usually dried plants and/or parts of plants are used, which can be mechanically comminuted prior to extraction. All comminution methods known to the person skilled in the art are suitable here, freeze grinding being mentioned as an example. Organic solvents, water (preferably hot water at a temperature above 80° C. and in particular above 95° C.) or mixtures of organic solvents and water, in particular low molecular weight alcohols with more or less high water contents, can be used as solvents for carrying out the extractions. Extraction with distilled or non-distilled water, methanol, ethanol, pentane, hexane, heptane, acetone, propylene glycols, polyethylene glycols and ethyl acetate and mixtures thereof and aqueous mixtures of the organic solvents is particularly preferred. Extraction with distilled or non-distilled water, methanol, ethanol and the aqueous solutions of the two alcohols is particularly preferred. The extraction usually takes place at 20 to 100° C., preferably at 30 to 90° C., in particular at 60 to 80° C. In a preferred embodiment, the extraction takes place under an inert gas atmosphere to avoid oxidation of the active substances in the extract. This is particularly important for extractions at temperatures above 40 C. The extraction times are determined by a person skilled in the art depending on the starting material, the extraction process, the extraction temperature, the ratio of solvent to raw material, etc. set. After the extraction, the raw extracts obtained can optionally be subjected to further customary steps such as, for example, purification, concentration and/or decolorization. If desired, the extracts produced in this way can, for example, be subjected to selective removal of individual undesirable ingredients. Extraction can be done to any degree of extraction, but is usually carried out to exhaustion. Typical yields (=amount of dry matter in the extract based on the amount of raw material used) in the extraction of dried leaves are in the range from 3 to 20% by weight, in particular 6 to 10% by weight. The present invention encompasses the finding that the extraction conditions and the yields of the final extracts can be selected by a person skilled in the art depending on the desired area of use. These extracts, which generally have active substance contents (=solids contents) in the range from 0.5 to 10% by weight, can be used as such, but it is also possible to completely remove the solvent by drying, in particular by spray drying or freeze drying . The extracts can also serve as starting materials for the production of the pure active ingredients, provided these cannot be produced synthetically in a simpler and more cost-effective manner. Active ingredients Instead of the extracts, the active ingredients contained in the surviving fractions can also be used individually or in mixtures, and these can be products that are obtained by purification of the extracts or synthetically. The products which can be obtained by purification from the extracts according to the invention are particularly preferred. Typical examples of suitable active ingredients are osmolytes (e.g. octulose, sucrose, glucose, trehalose, fructose, glucosyl-9-glycerol, xyloglucans, methyl ester of pectin), terpenes (e.g. carvone, perillic alcohol), antioxidants (e.g. arbutin, anthocyanins, superoxide dismutase, glutathione reductase, ascorbate peroxidase) and phytohormones (e.g. abscisic acid). In a particular embodiment of the invention, the preparations contain extracts which have effective levels of osmolytes, terpenes, antioxidants and/or phytohormones. Octulose, arbutin, abscisic acid and mixtures thereof are of particular importance. The extracts are used in effective amounts, i. H. depending on the amount of active substances contained therein (=amount of solids) in concentrations of 0.001 to 1% by weight, preferably 0.01 to 0.1% by weight, based in each case on the amount of active substance and final preparation. For the pure active ingredients, the quantities apply accordingly. Commercial applicability Further objects of the invention relate to the use of extracts from resurrection plants for the production of cosmetic and/or pharmaceutical preparations and as active ingredients > to regulate the water balance in the skin or to regulate moisture in the skin > to strengthen cell metabolism to ward off damaging environmental influences , in particular for cell protection against environmental influences such as heat shock, cold shock or osmotic shock; > to protect skin and hair against damage caused by UV radiation, > to protect skin and hair from free radicals and > to protect the macromolecules in skin cells and cell membranes. Finally, further objects of the invention relate to the use of octulose, arbutin and/or abscisic acid for the production of cosmetic and/or pharmaceutical preparations. Cosmetic and/or pharmaceutical preparations The extracts or active ingredients according to the invention can be used to produce cosmetic and/or pharmaceutical preparations, such as hair shampoos, hair lotions, bubble baths, shower baths, creams, gels, lotions, alcoholic and aqueous/alcoholic solutions, emulsions, wax/ fat masses, stick preparations, powders or ointments. These agents can also contain, as additional auxiliaries and additives, mild surfactants, oils, emulsifiers, pearlescent waxes, bodying agents, thickeners, superfatting agents, stabilizers, polymers, silicone compounds, fats, waxes, lecithins, phospholipids, biogenic active ingredients, UV light protection factors, antioxidants, Deodorants, antiperspirants, antidandruff agents, film formers, swelling agents, insect repellents, self-tanners, tyrosine inhibitors (depigmenting agents), hydrotropes, solubilizers, preservatives, perfume oils, dyes and the like. Surfactants Anionic, nonionic, cationic and/or amphoteric or amphoteric surfactants can be present as surface-active substances, the proportion of which in the agents is usually about 1 to 70%, preferably 5 to 50% and in particular 10 to 30% by weight. Typical examples of anionic surfactants are soaps, alkyl benzene sulfonates, alkane sulfonates, olefin sulfonates, alkyl ether sulfonates, glycerol ether sulfonates, α-methyl ester sulfonates, sulfofatty acids, alkyl sulfates, fatty alcohol ether sulfates, glycerol ether sulfates, fatty acid ether sulfates, hydroxy mixed ether sulfates, monoglyceride (ether) sulfates, fatty acid amide (ether) sulfates, mono- and dialkyl sulfosuccinates , mono- and dialkyl sulfosuccinamates, sulfotriglycerides, amide soaps, ether carboxylic acids and their salts, fatty acid isethionates, fatty acid sarcosinates, fatty acid taurides, N-acylamino acids such as acyl lactylates, acyl tartrates, acyl glutamates and acyl aspartates, alkyl oligoglucoside sulfates, protein fatty acid condensates (in particular wheat-based vegetable products) and alkyl ( ether) phosphates. If the anionic surfactants contain polyglycol ether chains, these can have a conventional, but preferably a narrow homolog distribution. Typical examples of nonionic surfactants are fatty alcohol polyglycol ethers, alkylphenol polyglycol ethers, fatty acid polyglycol esters, fatty acid amide polyglycol ethers, fatty amine polyglycol ethers, alkoxylated triglycerides, mixed ethers or mixed formals, optionally partially oxidized alk(ene)yl oligoglycosides or glucuronic acid derivatives, fatty acid N-alkylglucamides, protein hydrolysates (especially wheat-based plant products) , polyol fatty acid esters, sugar esters, sorbitan esters, polysorbates and amine oxides. If the nonionic surfactants contain polyglycol ether chains, these can have a conventional, but preferably a narrow homolog distribution. Typical examples of cationic surfactants are quaternary ammonium compounds, such as dimethyl distearyl ammonium chloride, and ester quats, in particular quaternized fatty acid trialkanolamine ester salts. Typical examples of amphoteric or zwitterionic surfactants are alkyl betaines, alkyl amido betaines, aminopropionates, aminoglycinates, imidazolinium betaines and sulfobetaines. The surfactants mentioned are exclusively known compounds. With regard to the structure and production of these substances, reference is made to relevant reviews, for example J. Falbe (ed.), "Surfactants in Consumer Products", Springer Verlag, Berlin, 1987, pp. 54-124 or J. Falbe (ed.), "Katalysatoren , Surfactants and mineral oil additives", Thieme Verlag, Stuttgart, 1978, p. 123217. Typical examples of particularly suitable mild, i. H. Skin-like surfactants are particularly skin-in-case alcohol-polyglycolethersulfate, monoglyceride sulfate, monound/or dialkylsulfosuccinate, fatty acid, fatty acid, fatty acid restaurant, a-olefinsulfonate, alcoholol, alcoholol Igoglucoside, fatty acid gucamide, alkylamidobetaine, amphoacetale and/or protein fatty acid conference, the latter preferably based on wheat proteins. Oil components Examples of oil components are Guerbet alcohols based on fatty alcohols having 6 to 18, preferably 8 to 10 carbon atoms, esters of linear C6-C22 fatty acids with linear or branched C6-C22 fatty alcohols or esters of branched Ce-Cis carboxylic acids with linear or branched C6-C22 fatty alcohols, such as. B. myristyl myristate, myristyl palmitate, myristyl stearate, myristyl isostearate, myristyl oleate, myristyl behenate, myristyl rucate, cetyl myristate, cetyl palmitate, cetyl stearate, cetylisostearate, cetyl oleate, cetyl behenate, cetyl erucate, stearyl myristate, stearyl palmitate, stearyl stearate, stearyl isostearate, stearyl oleate, stearyl behenate, stearyl erucate, isostearyl myristate, isostearyl palmitate, isostearyl stearate, I sostearyl isostearate, isostearyl oleate, isostearyl behenate, isostearyl oleate, oleyl myristate, oleyl palmitate, oleyl stearate, oleyl isostearate, oleyl oleate, oleyl behenate, oleyl lerucate, behenyl myristate, behenyl palmitate, behenyl stearate, behenyl isostearate, behenyl oleate, behenyl behenate, behenyleruca t, erucyl myristate, erucyl palmitate, erucyl stearate, erucyl isostearate, erucyl oleate, erucyl behenate and erucyl erucate . Also suitable are esters of linear C6-C22 fatty acids with branched alcohols, especially 2-ethylhexanol, esters of C18-C38-alkylhydroxycarboxylic acids with linear or branched C6-C22 fatty alcohols (cf. DE 19756377 A1), especially dioctyl malate, Esters of linear and/or branched fatty acids with polyhydric alcohols (e.g. propylene glycol, dimerdiol or trimertriol) and/or Guerbet alcohols, triglycerides based on C6-Clo fatty acids, liquid mono-/di-/triglyceride mixtures based on C6- Cl8 fatty acids, esters of C6-C2z fatty alcohols and/or Guerbet alcohols with aromatic carboxylic acids, in particular benzoic acid, esters of C2-C12 dicarboxylic acids with linear or branched alcohols having 1 to 22 carbon atoms or polyols having 2 to 10 carbon atoms and 2 to 6 Hydroxyl groups, vegetable oils, branched primary alcohols, substituted cyclohexanes, linear and branched C6-C22 fatty alcohol carbonates, such as. B. dicaprylyl carbonates (Cetiol0 CC), Guerbet carbonates based on fatty alcohols having 6 to 18, preferably 8 to 10 C atoms, esters of benzoic acid with linear and/or branched C6-C22 alcohols (e.g. Finso) v@ TN), linear or branched, symmetrical or unsymmetrical dialkyl ethers having 6 to 22 carbon atoms per alkyl group, such as. B. dicaprylyl ether (Cetiol0 OE), ring opening products of epoxidized fatty acid esters with polyols, silicone oils (cyclomethicone, silicium methicone types, etc.) and/or aliphatic or naphthenic hydrocarbons, such as e.g. B. such as squalane, squalene or dialkylcyclohexanes. Emulsifiers Examples of suitable emulsifiers are nonionic surfactants from at least one of the following groups: adducts of 2 to 30 moles of ethylene oxide and/or 0 to 5 moles of propylene oxide onto linear fatty alcohols containing 8 to 22 carbon atoms, onto fatty acids containing 12 to 22 carbon atoms Atoms to alkylphenols having 8 to 15 carbon atoms in the alkyl group and alkylamines having 8 to 22 carbon atoms in the alkyl radical; Alkyl and/or alkenyl oligoglycosides having 8 to 22 carbon atoms in the alk(en)yl radical and their ethoxylated analogues; Addition products of 1 to 15 moles of ethylene oxide with castor oil and/or hardened castor oil; Addition products of 15 to 60 moles of ethylene oxide with castor oil and/or hardened castor oil; Partial esters of glycerol and/or sorbitan with unsaturated, linear or saturated, branched fatty acids having 12 to 22 carbon atoms and/or hydroxycarboxylic acids having 3 to 18 carbon atoms and their adducts with 1 to 30 mol ethylene oxide; Partial esters of polyglycerol (average degree of self-condensation 2 to 8), polyethylene glycol (molecular weight 400 to 5000), trimethylolpropane, pentaerythritol, sugar alcohols (e.g. sorbitol), alkyl glucosides (e.g. methyl glucoside, butyl glucoside, lauryl glucoside) and polyglucosides ( eg cellulose) with saturated and/or unsaturated, linear or branched fatty acids having 12 to 22 carbon atoms and/or hydroxycarboxylic acids having 3 to 18 carbon atoms and their adducts with 1 to 30 mol ethylene oxide; > Mixed esters of pentaerythritol, fatty acids, citric acid and fatty alcohol according to DE 1165574 PS and/or mixed esters of fatty acids having 6 to 22 carbon atoms, methyl glucose and polyols, preferably glycerol or polyglycerol. mono-, di- and tri-alkyl phosphates and mono-, di- and/or tri-PEG-alkyl phosphates and their salts; > wool wax alcohols ; polysiloxane-polyalkyl-polyether copolymers or corresponding derivatives; block copolymers e.g. B. polyethylene glycol-30 dipolyhydroxystearates; polymer emulsifiers, e.g. B. Pemulen types (TR-1, TR-2) from Goodrich; polyalkylene glycols and glycerol carbonate. Ethylene oxide addition products The addition products of ethylene oxide and/or propylene oxide with fatty alcohols, fatty acids, alkylphenols or castor oil are known, commercially available products. These are homologous mixtures whose average degree of alkoxylation corresponds to the ratio of the amounts of ethylene oxide and/or propylene oxide and substrate with which the addition reaction is carried out. Civils fatty acid mono- and diesters of addition products of ethylene oxide with glycerol are known from DE 2024051 PS as moisturizing agents for cosmetic preparations. Alkyl and/or alkenyl oligoglycosides, their preparation and their use are known from the prior art. They are produced in particular by reacting glucose or oligosaccharides with primary alcohols having 8 to 18 carbon atoms. With regard to the glycoside residue, both monoglycosides, in which a cyclic sugar residue is glycosidically bonded to the fatty alcohol, and oligomeric glycosides with a degree of oligomerization of preferably up to about 8 are suitable. The degree of oligomerization is a statistical mean value, which is based on a homolog distribution that is customary for such technical products. Partial glycerides Typical examples of suitable partial glycerides are hydroxystearic acid monoglyceride, hydroxystearic acid diglyceride, isostearic acid monoglyceride, isostearic acid diglyceride, oleic acid monoglyceride, oleic acid diglyceride, ricinoleic acid moglyceride, ricinoleic acid diglyceride, linoleic acid monoglyceride, linoleic acid diglyceride, linolenic acid monoglyceride, linolenic acid diglyceride, erucic acid monoglyceride, erucic acid diglyceride, tartaric acid monoglyceride, tartaric acid diglyceride, citric acid monoglyceride, lemon diglyceride, malic acid monoglyceride, malic acid diglyceride and their technical mixtures that may contain small amounts of triglycerides from the manufacturing process. Addition products of 1 to 30, preferably 5 to 10, moles of ethylene oxide onto the partial glycerides mentioned are also suitable. Sorbitan esters Sorbitan esters are sorbitan monoisostearate, sorbitan sesquiisostearate, sorbitan diisostearate, sorbitan triisostearate, sorbitan monooleate, sorbitan sesquioleate, sorbitan dioleate, sorbitan trioleate, sorbitan monoerucate, sorbitan sesquierucate, sorbitan diericate, sorbitan trierucate, sorbitan monoricinoleate, sorbitan sesqui ricinoleate, sorbitan iricinoleate, sorbitan triricinoleate, sorbitan monohydroxystearate, sorbitan sesquihydroxystearate, sorbitan dihydroxystearate, sorbitan trihydroxystearate, sorbitan monotartrate, sorbitan sesquitartrate, Sorbitan ditartrate, sorbitan tartrate, sorbitan monocitrate, sorbitan sesquicitrate, sorbitan citrate, sorbitan tricitrate, sorbitan monomaleate, sorbitan sesquimaleate, sorbitan dimaleate, sorbitan trimaleate and technical mixtures thereof. Addition products of 1 to 30, preferably 5 to 10, moles of ethylene oxide onto the sorbitan esters mentioned are also suitable. Polyglycerol esters Typical examples of suitable polyglycerol esters are polyglyceryl-2 dipolyhydroxystearate (Dehymuls® PGPH), polyglycerol-3-diisostearate (Lameforme TGI), polyglyceryl-4 isostearate (Iso ! an® GI 34), polyglyceryl-3 oleate, diisostearoyl polyglyceryl-3 diisostearate ( Iso) an@ PDI), Polyglyceryl-3 Methylglucose Distearate (Tego Care™ 450), Polyglyceryl-3 Beeswax (Cera Bellina3), Polyglyceryl-4 Caprate (Polyglycerol Caprate T2010/90), Polyglyceryl-3 Cetyl Ether (Chimexanee NL), Polyglyceryl-3 Distearate (Cremophord3 GS 32) and polyglyceryl polyricinoleate (AdmulQ3 WOL 1403) polyglyceryl dimerate isostearate and mixtures thereof. Examples of other suitable polyol esters are the mono-, di- and triesters of trimethylolpropane or pentaerythritol with lauric acid, coconut fatty acid, tallow fatty acid, palmitic acid, stearic acid, oleic acid, behenic acid and the like, optionally reacted with 1 to 30 moles of ethylene oxide. Anionic Emulsifiers Typical anionic emulsifiers are aliphatic fatty acids containing 12 to 22 carbon atoms, such as palmitic acid, stearic acid or behenic acid, and dicarboxylic acids containing 12 to 22 carbon atoms, such as azelaic acid or sebacic acid. Amphoteric and cationic emulsifiers Zwitterionic surfactants can also be used as emulsifiers. Zwitterionic surfactants are surface-active compounds which contain at least one quaternary ammonium group and at least one carboxylate and one sulfonate group in the molecule. Particularly suitable zwitterionic surfactants are the so-called betaines, such as the N-alkyl-N,N-dimethylammonium glycinates, for example coconut alkyldimethylammonium glycinate, N-acylaminopropyl-N,N-dimethylammonium glycinates, for example cocoacylaminopropyldimethylammonium glycinate, and 2-alkyl-3-carboxylmethyl-3 -hydroxyethylimidazolines each having 8 to 18 carbon atoms in the alkyl or acyl group and the cocoacylaminoethylhydroxyethylcarboxymethyl glycinate. The fatty acid amide derivative known under the CTFA name Cocamidopropyl Betaine is particularly preferred. Ampholytic surfactants are also suitable emulsifiers. Ampholytic surfactants are surface-active compounds which, in addition to a C8/18-alkyl or acyl group, contain at least one free amino group and at least one —COOH or —SO3H group in the molecule and are capable of forming inner salts. Examples of suitable ampholytic surfactants are N-alkylglycines, N-alkylpropionic acids, N-alkylaminobutyric acids, N-alkyliminodipropionic acids, N-hydroxyethyl-N-alkylamidopropylglycines, N-alkyltaurines, N-alkylsarcosines, 2-alkylaminopropionic acids and alkylaminoacetic acids, each with about 8 up to 18 carbon atoms in the alkyl group.. Particularly preferred ampholytic surfactants are N-cocoalkylaminopropionate, cocoacylaminoethylaminopropionate and C12/18-acylsarcosine. Finally, cationic surfactants can also be used as emulsifiers, with those of the esterquat type, preferably methyl-quaternized difatty acid triethanolamine ester salts, being particularly preferred. Fats and waxes Typical examples of fats are glycerides, i. H. solid or liquid plant or animal products, which consist essentially of mixed glycerol esters of higher fatty acids, as waxes include u. natural waxes such as B. candelilla wax, carnauba wax, Japan wax, esparto grass wax, cork wax, guaruma wax, rice germ oil wax, sugar cane wax, ouricury wax, montan wax, beeswax, shellac wax, spermaceti, lanolin (wool wax), rump fat, ceresin, ozokerite (earth wax), petrolatum, paraffin waxes, microwaxes; chemically modified waxes (hard waxes), such as As montan ester waxes, sasol waxes, hydrogenated jojoba waxes and synthetic waxes such. B. polyalkylene waxes and polyethylene glycol waxes in question. In addition to the fats, fat-like substances such as lecithins and phospholipids can also be used as additives. Those skilled in the art understand the term lecithins to mean those glycero-phospholipids which are formed from fatty acids, glycerol, phosphoric acid and choline by esterification. Lecithins are therefore also often referred to in the professional world as phosphatidylcholines (PC). Examples of natural lecithins are the kephalins, which are also known as phosphatidic acids and are derivatives of 1,2-diacyl-sn-glycerol-3-phosphoric acids. In contrast, phospholipids are usually understood to be monoesters and preferably diesters of phosphoric acid with glycerol (glycerol phosphates), which are generally classed as fats. In addition, sphingosines and sphingolipids are also possible. Pearlescent Waxes Suitable pearlescent waxes are, for example: alkylene glycol esters, specifically ethylene glycol distearate; fatty acid alkanolamides, especially coconut fatty acid diethanolamide; partial glycerides, especially stearic acid monoglyceride; esters of polybasic, optionally hydroxy-substituted carboxylic acids with fatty alcohols having 6 to 22 carbon atoms, specifically long-chain esters of tartaric acid; Fatty substances, such as fatty alcohols, fatty ketones, fatty aldehydes, fatty ethers and fatty carbonates, which have a total of at least 24 carbon atoms, specifically lauron and distearyl ether; Fatty acids such as stearic acid, hydroxystearic acid or behenic acid, ring-opening products of olefin epoxides having 12 to 22 carbon atoms with fatty alcohols having 12 to 22 carbon atoms and/or polyols having 2 to 15 carbon atoms and 2 to 10 hydroxyl groups, and mixtures thereof. Consistency agents and thickeners Consistency factors are primarily fatty alcohols or hydroxyfatty alcohols having 12 to 22 and preferably 16 to 18 carbon atoms and also partial glycerides, fatty acids or hydroxyfatty acids. A combination of these substances with alkyl oligoglucosides and/or fatty acid N-methyl glucamides of the same chain length and/or polyglycerol poly-12-hydroxystearates is preferred. Suitable thickeners are, for example, Aerosil types (hydrophilic silicic acids), polysaccharides, in particular xanthan gum, guar guar, agar-agar, alginates and tyloses, carboxymethyl cellulose and hydroxyethyl and hydroxypropyl cellulose, also higher molecular weight polyethylene glycol mono- and diesters of fatty acids, polyacrylates, ( e.g., CarbopoleX and Pemulen grades from Goodrich; Synthalene0 from Sigma; Keltrol grades from Kelco; Sepigel grades from Seppic; Salcare grades from Allied Colloids), polyacrylamides, polymers, polyvinyl alcohol and polyvinylpyrrolidone. Bentonites, such as e.g. B. Bentone® Gel VS-5PC (Rheox), which is a mixture of cyclopentasiloxane, disteardimonium hectorite and propylene carbonate. Surfactants such as ethoxylated fatty acid glycerides, esters of fatty acids with polyols such as pentaerythritol or trimethylolpropane, fatty alcohol ethoxylates with a narrow homolog distribution or alkyl oligoglucosides and electrolytes such as sodium chloride and ammonium chloride are also suitable. Superfatting agents Substances such as lanolin and lecithin and polyethoxylated or acylated lanolin and lecithin derivatives, polyol fatty acid esters, monoglycerides and fatty acid alkanolamides can be used as superfatting agents, the latter also serving as foam stabilizers. Stabilizers As stabilizers, metal salts of fatty acids, such as. B. magnesium, aluminum and / or zinc stearate or ricinoleate can be used. Polymers Suitable cationic polymers are, for example, cationic cellulose derivatives, such as. B. a quaternized hydroxyethyl cellulose sold under the name Polymer JR 400@ available from Amerchol, cationic starch, copolymers of diallylammonium salts and acrylamides, quaternized vinylpyrrolidone/vinylimidazole polymers such as e.g. B. Luviquate (BASF), condensation products of polyglycols and amines, quaternized collagen polypeptides, such as Lauryidimonium Hydroxypropyl Hydrolyzed Collagen (Lamequatd3L/Grünau), quaternized wheat polypeptides, polyethyleneimine, cationic silicone polymers, such as. e.g. amodimethicone, copolymers of adipic acid and dimethylaminohydroxypropyldiethylenetriamine (Cartaretine®/Sandoz), copolymers of acrylic acid with dimethyldiallylammonium chloride (Merquate 550/Chemviron), polyaminopolyamides, such as e.g. B. described in FR 2252840 A and their crosslinked water-soluble polymers, cationic chitin derivatives such as quaternized chitosan, optionally distributed microcrystalline, condensation products of dihaloalkyls, such as. B. dibromobutane with bisdialkylamines, such as. B. Bis-dimethylamino-1,3-propane, cationic guar gum, e.g. B. Jaguar@ CBS, Jaguar@ C-17, Jaguar@ C-16 from Celanese, quaternized ammonium salt polymers, such as. B. Mirapo ! " A-15, Mirapolo AD-1, Mirapole AZ-1 from Miranol. Examples of anionic, zwitterionic, amphoteric and nonionic polymers are vinyl acetate/crotonic acid copolymers, vinylpyrrolidone/vinyl acrylate copolymers, vinyl acetate/butyl maleate/isobornyl acrylate copolymers, methyl vinyl ether/maleic anhydride copolymers and esters thereof, uncrosslinked polyacrylic acids and polyacrylic acids crosslinked with polyols, acrylamidopropyltrimethylammonium chloride /acrylate copolymers, octylacrylamide/methyl methacrylate/tert. Butylaminoethyl methacrylate/2-hydroxypropyl methacrylate copolymers, polyvinylpyrrolidone, vinylpyrrolidone/vinyl acetate copolymers, vinylpyrrolidone/dimethylaminoethyl methacrylate/vinylcaprolactam terpolymers and optionally derivatized cellulose ethers and silicones. Other suitable polymers and thickeners are found in Cosm. Toil 108 , 95 (1993). Silicone Compounds Suitable silicone compounds are, for example, dimethylpolysiloxanes, methylphenylpolysiloxanes, cyclic silicones and amino-, fatty acid-, alcohol-, polyether-, epoxy-, fluorine-, glycoside- and/or alkyl-modified silicone compounds, which can be liquid or resinous at room temperature. Also suitable are simethicones, which are mixtures of dimethicones with an average chain length of 200 to 300 dimethylsiloxane units and hydrogenated silicates. A detailed overview of suitable volatile silicones can also be found by Todd et al. in cosm. Toil 91 , 27 (1976). UV Light Protection Filters and Antioxidants In addition to the extracts according to the invention or the effective contents of active ingredients in these extracts as active ingredients against damage caused by UV radiation, further UV light protection factors can also be used. UV sun protection factors are to be understood, for example, as organic substances (sun protection filters) that are liquid or crystalline at room temperature and are able to absorb ultraviolet rays and release the absorbed energy in the form of longer-wave radiation, e.g. B. to give off heat again. UVB filters can be oil-soluble or water-soluble. As oil-soluble substances such. Examples include: >3-benzylidenecamphor or 3-benzylidenenorcamphor and derivatives thereof, e.g. B. 3-(4-methylbenzylidene)camphor as described in EP 0693471 B1; >4-aminobenzoic acid derivatives, preferably 2-ethylhexyl 4-(dimethylamino)benzoate, 2-octyl 4-(dimethylamino)benzoate and amyl 4-(dimethylamino)benzoate; Esters of cinnamic acid, preferably 2-ethylhexyl 4-methoxycinnamate, propyl 4-methoxycinnamate, isoamyl 4-methoxycinnamate, 2-ethylhexyl 2-cyano-3,3-phenylcinnamate (octocrylene); > Esters of salicylic acid, preferably 2-ethylhexyl salicylate, 4-isopropylbenzyl salicylate, homomenthyl salicylate; > Derivatives of benzophenone, preferably 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2-dihydroxy-4-methoxybenzophenone; > Esters of benzalmalonic acid, preferably di-2-ethylhexyl 4-methoxybenzmalonate; > Triazine derivatives, e.g. B. 2,4,6-trianilino-(p-carbo-2-ethyl-1-hexyloxy)-1,3,5-triazine and octyl triazone, as described in EP 0818450 AI or dioctyl butamido triazone (Uvasorbd3 HEB) ; propane-1,3-dione, such as e.g. B. 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione; > Ketotricyclo (5.2.1.0) decane derivatives as described in EP 0694521 B1. Suitable water-soluble substances are: >2-phenylbenzimidazole-5-sulfonic acid and its alkali metal, alkaline earth metal, ammonium, alkylammonium, alkanolammonium and glucammonium salts; >Sulfonic acid derivatives of benzophenones, preferably 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and its salts; > Sulfonic acid derivatives of 3-benzylidene camphor, e.g. B. 4- (2-oxo-3-bornylidenemethyl) benzenesulfonic acid and 2-methyl-5- (2-oxo-3-bornylidene) sulfonic acid and salts thereof. Derivatives of benzoylmethane, such as, for example, 1-(4-tert.butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione, 4-tert.butyl-4, come into consideration as typical UV-A filters - methoxydibenzoylmethane (Parsolo 1789), 1-phenyl-3-(4-isopropylphenyl)propane-1,3-dione and enamine compounds, as described in DE 19712033 AI (BASF). The UV-A and UV-B filters can of course also be used in mixtures. Particularly favorable combinations consist of the derivatives of benzoylmethane, for example 4-tert-butyl-e-methoxydibenzoylmethane (Parsoi® 1789) and 2-ethylhexyl 2-cyano-3,3-phenylcinnamate (octocrylene) in combination with ester of cinnamic acid, preferably 2-ethylhexyl 4-methoxycinnamate and/or propyl 4-methoxycinnamate and/or isoamyl 4-methoxycinnamate -, alkylammonium, alkanolammonium and glucammonium salts combined. In addition to the soluble substances mentioned, insoluble light protection pigments, namely finely dispersed metal oxides or salts, can also be used for this purpose. Examples of suitable metal oxides are, in particular, zinc oxide and titanium dioxide and also oxides of iron, zirconium, silicon, manganese, aluminum and cerium and mixtures thereof Silicates (talc), barium sulfate or zinc stearate can be used as salts. The oxides and salts are used in the form of pigments for skin-care and skin-protecting emulsions and decorative cosmetics. The particles should have an average diameter of less than 100 nm, preferably between 5 and 50 nm and in particular between 15 and 30 nm. They can have a spherical shape, but it is also possible to use particles that have an ellipsoidal shape or a shape that deviates in some other way from the spherical shape. The pigments can also be surface treated, e.g. H. hydrophilized or hydrophobic. Typical examples are coated titanium dioxides, e.g. B. Titanium dioxide T 805 (Degussa) or Eusolex T2000 (Merck). Silicones in particular, and especially trialkoxyoctylsilanes or simethicones, come into consideration as hydrophobic coating agents. So-called micro- or nanopigments are preferably used in sunscreens. Preferably micronized zinc oxide is used. Other suitable UV light protection filters are the overview by P. Finkel in SÖFW-Journal 122, 543 (1996) and Parf. cosm. 3 11 (1999). In addition to the two aforementioned groups of primary sunscreens, secondary sunscreens of the antioxidant type can also be used, which interrupt the photochemical reaction chain that is triggered when UV radiation penetrates the skin. Typical examples are amino acids (e.g. glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (e.g. urocanic acid) and their derivatives, peptides such as D, L-carnosine, D-carnosine, L-carnosine and their derivatives (e.g. anserine), carotenoids, carotenes (e.g. a-carotene, ss-carotene, lycopene) and their derivatives, chlorogenic acid and its derivatives, lipoic acid and its derivatives (e.g. dihydrolipoic acid), aurothioglucose , propylthiouracil and other thiols (e.g. thioredoxin, glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl, Oleyl, γ-linoleyl, cholesteryl and glyceryl esters) and their salts, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and their derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) and sulfoximine compounds (e.g. buthionine sulfoximine, homocysteine sulfoximine). , butionine sulfones, penta-, hexa-, heptathionine sulfoximine) in very low tolerable doses (e.g. e.g. pmol to limol/kg), also (metal) chelators (e.g. a hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin), a-hydroxy acids (e.g. citric acid, lactic acid, malic acid), humic acid, bile acid, bile extracts , bilirubin, biliverdin, EDTA, EGTA and their derivatives, unsaturated fatty acids and their derivatives (e.g. y-linolenic acid, linoleic acid, oleic acid), folic acid and their derivatives, ubiquinone and ubiquinol and their derivatives, vitamin C and derivatives (e.g. B. ascorbyl palmitate, magnesium ascorbyl phosphate, ascorbyl acetate), tocopherols and derivatives (e.g. vitamin E acetate), vitamin A and derivatives (vitamin A palmitate) and coniferyl benzoate of benzoin, rutic acid and its derivatives, a-glycosyl rutin , ferulic acid, furfurylidene glucitol, carnosine, butylated hydroxytoluene, butylated hydroxyanisole, nordihydroguaiac acid, nordihydroguajaretic acid, trihydroxybutyrophenone, uric acid and its derivatives, mannose and its derivatives, superoxide dismutase, zinc and its derivatives (e.g. ZnO, ZnS04) selenium and its derivatives (e.g. B. selenium methionine), stilbenes and derivatives thereof (e.g. stilbene oxide, trans-stilbene oxide) and the derivatives suitable according to the invention (salts, esters, ethers, sugars, nucleotides, nucleosides, peptides and lipids) of these active ingredients. Biogenic active ingredients Among biogenic active ingredients are, for example, tocopherol, tocopherol acetate, tocopherol palmitate, ascorbic acid, (deoxy)ribonucleic acid and its fragmentation products, ss glucans, retinof, bisabolol, allantoin, phytantriol, panthenol, AHA acids, amino acids, ceramides, pseudoceramides, essential oils , other plant extracts and vitamin complexes. Deodorants and antiseptics Cosmetic deodorants (deodorants) counteract, mask or eliminate body odors. Body odors are caused by the action of skin bacteria on apocrine sweat, forming unpleasant-smelling degradation products. Accordingly, deodorants contain active ingredients that act as germ inhibitors, enzyme inhibitors, odor absorbers or odor maskers. > Germ-inhibiting agents In principle, all substances that are effective against gram-positive bacteria are suitable as germ-inhibiting agents, e.g. B. 4-Hydroxybenzoic acid and its salts and esters, N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)urea, 2,4,4'-trichloro-2'-hydroxy-diphenyl ether (triclosan), 4 -chloro-3,5-dimethyl-phenol, 2,2'-methylene-bis(6-bromo-4-chlorophenol), 3-methyl-4-(1-methylethyl)-phenol, 2-benzyl-4-chlorophenol, 3-(4-Chlorophenoxy)-1,2-propanediol, 3-Iodo-2-propynylbutylcarbamate, Chlorhexidine, 3,4,4'-Trichlorocarbanilide (TTC), Antibacterial Fragrances, Thymol, Thyme Oil, Eugenol, Clove Oil, Menthol, Mint Oil , farnesol, phenoxyethanol, glycerol monocaprate, glycerol monocaprylate, glycerol monolaurate (GML), diglycerol monocaprate (DMC), salicylic acid-N-alkylamides such as e.g. B. salicylic acid-n-octylamide or salicylic acid-n-decylamide. > Enzyme inhibitors Esterase inhibitors, for example, are suitable as enzyme inhibitors. These are preferably trialkyl citrates such as trimethyl citrate, tripropyl citrate, triisopropyl citrate, tributyl citrate and, in particular, triethyl citrate (Hydagenq3 CAT). The substances inhibit enzyme activity and thereby reduce odor formation. Other substances that come into consideration as esterase inhibitors are sterol sulfates or phosphates, such as lanosterol, cholesterol, campesterol, stigmasterol and sitosterol sulfate or phosphate, dicarboxylic acids and their esters, such as glutaric acid, monoethyl glutarate, diethyl glutarate, adipic acid , Adipic acid mono ethyl ester, adipic acid diethyl ester, malonic acid and malonic acid diethyl ester, hydroxycarboxylic acids and their esters such as citric acid, malic acid, tartaric acid or tartaric acid diethyl ester, and zinc glycinate. > Odor absorbers Substances that absorb odor-forming compounds and can largely retain them are suitable as odor absorbers. They lower the partial pressure of the individual components and thus also reduce their speed of propagation. It is important that perfumes remain unaffected. Odor absorbers are not effective against bacteria. They contain, for example, a complex zinc salt of ricinoleic acid as the main component or special, largely odorless fragrances known to those skilled in the art as “fixateurs”, such as, for example, B. extracts of labdanum or styrax or certain abietic acid derivatives. Fragrances or perfume oils act as odor maskers, which, in addition to their function as odor maskers, give the deodorants their respective fragrance. Perfume oils which may be mentioned are, for example, mixtures of natural and synthetic fragrances. Natural fragrances are extracts from blossoms, stems and leaves, fruits, fruit peels, roots, wood, herbs and grasses, needles and twigs as well as resins and balms. Animal raw materials are also possible, such as civet and castoreum. Typical synthetic fragrance compounds are products of the ester, ether, aldehyde, ketone, alcohol and hydrocarbon type. Perfume compounds of the ester type are z. B. benzyl acetate, p-tert-butylcyclohexyl acetate, linalyl acetate, phenylethyl acetate, linalyl benzoate, benzyl formate, allylcyclohexyl propionate, styrallyl propionate and benzyl salicylate. The ethers include, for example, benzyl ethyl ether, the aldehydes z. B. the linear alkanals having 8 to 18 carbon atoms, citral, citronellal, citronellyloxyacetaldehyde, cyclamenaldehyde, hydroxycitronellal, lilial and bourgeonal, to the ketones z. B. the Ionone and methylcedryl ketone, the alcohols anethole, citronellol, eugenol, isoeugenol, geraniol, linalool, phenylethyl alcohol and terpineol, the hydrocarbons mainly include the terpenes and balms. However, mixtures of different fragrances are preferably used, which together produce an attractive fragrance. B. sage oil, chamomile oil, clove oil, lemon balm oil, mint oil, cinnamon leaf oil, lime blossom oil, juniper berry oil, vetiver oil, olibanum oil, galbanum oil, labdanum oil and lavandin oil. Bergamot oil, dihydromyrcenol, lilial, lyral, citronellol, phenylethyl alcohol, a-hexylcinnamaldehyde, geraniol, benzylacetone, cyclamenaldehyde, linalool, boisambrene forte, ambroxan, indole, hedione, sandelice, lemon oil, tangerine oil, orange oil, allylamyl glycolate, cyclovertal, lavandin oil, Clary sage oil, ss-damascone, bourbon geranium oil, cyclohexyl salicylate, Vertofix Coeur, Iso-E-Super, Fixolide NP, Evernyl, Iraldein gamma, phenylacetic acid, geranyl acetate, benzyl acetate, rose oxide, Romilat, Irotyl and Floramat alone or in mixtures. Antiperspirants Antiperspirants (antiperspirants) reduce perspiration by influencing the activity of the eccrine sweat glands and thus counteract underarm wetness and body odour. Aqueous or anhydrous formulations of antiperspirants typically contain the following ingredients: >astringent active ingredients, >oil components, >nonionic emulsifiers, >coemulsifiers, >consistency enhancers, >excipients such as e.g. B. thickeners or complexing agents and / or> non-aqueous solvents such. B. ethanol, propylene glycol and / or glycerol. Salts of aluminum, zirconium or zinc are particularly suitable as astringent antiperspirant active ingredients. Such suitable antiperspirant active ingredients are z. B. aluminum chloride, aluminum chlorohydrate, aluminum dichlorohydrate, aluminum sesquichlorhydrat and their complexes z. B. with propylene glycol-t, 2. aluminum hydroxyallantoinate, aluminum chloride tartrate, aluminum zirconium trichlorohydrate, aluminum zirconium tetrachlorohydrate, aluminum zirconium pentachlorohydrate and their complexes z. B. with amino acids such as glycine. In addition, conventional oil-soluble and water-soluble auxiliaries can be present in small amounts in antiperspirants. Such oil-soluble auxiliaries can, for. B. be: > anti-inflammatory, skin-protecting or fragrant essential oils, > synthetic skin-protecting active ingredients and/or > oil-soluble perfume oils. Usual water-soluble additives are e.g. B. preservatives, water-soluble fragrances, pH adjusters, z. B. buffer mixtures, water-soluble thickeners, z. B. water-soluble natural or synthetic polymers such. B. xanthan gum, hydroxyethyl cellulose, polyvinylpyrrolidone or high molecular weight polyethylene oxides. Film formers Common film formers are, for example, chitosan, microcrystalline chitosan, quaternized chitosan, polyvinylpyrrolidone, vinylpyrrolidone-vinyl acetate copolymers, polymers of the acrylic acid series, quaternary cellulose derivatives, collagen, hyaluronic acid or its salts and similar compounds. Anti-dandruff active ingredients Piroctone olamine (1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(lH)-pyridinone monoethanolamine salt), Baypival (D (climbazole), ketoconazole, (4-acetyl-1 - {-4-[2-(2. 4-dichlorophenyl)r-2-(lH-imidazol-1-ylmethyl)-1,3-dioxylan-c-4- ylmethoxyphenyllpiperazine, ketoconazole, elubiol, selenium disulphide, sulfur colloidal, Sulfur polyethylene glycol sorbitan monooleate, sulfur ricinol polyethoxylate, sulfur tar distillates, salicylic acid (or in combination with hexachlorophene), undexylenic acid monoethanolamide sulfosuccinate sodium salt, Lamepone UD (protein undecylenic acid condensate), zinc pyrithione, aluminum pyrithione and magnesium pyrithione/dipyrithione magnesium sulfate Swelling agents for aqueous phases can be montmorillonite, clay minerals, pemulen and alkyl-modified carbopol types (Goodrich) Other suitable polymers and swelling agents can be found in the review by R. Lochhead in Cosm Toil 108, 95 (1993). Insect repellents Suitable insect repellents are N,N-diethyl-m-toluamide, 1,2-pentanediol or ethyl butyl acetylaminopropionate. Self-tanners and depigmenting agents Dihydroxyacetone is a suitable self-tanner. Arbutin, ferulic acid, kojic acid, coumaric acid and ascorbic acid (vitamin C) are examples of tyrosine inhibitors that prevent the formation of melanin and are used in depigmenting agents. Hydrotropes Hydrotropes such as ethanol, isopropyl alcohol or polyols can also be used to improve the flow behavior. Polyols contemplated herein preferably have 2 to 15 carbon atoms and at least two hydroxyl groups. The polyols can also contain other functional groups, in particular amino groups, or be modified with nitrogen. Typical examples are >glycerin; > Alkylene glycols, such as ethylene glycol, diethylene glycol, propylene glycol, butylene glycol, hexylene glycol and polyethylene glycols with an average molecular weight of 100 to 1,000 daltons; > Technical oligoglycerol mixtures with a self-condensation degree of 1.5 to 10, such as technical diglycerol mixtures with a diglycerol content of 40 to 50% by weight; >Methylol compounds, such as in particular trimethylolethane, trimethylolpropane, trimethylolbutane, pentaerythritol and dipentaerythritol; > Lower alkyl glucosides, in particular those with 1 to 8 carbons in the alkyl radical, such as methyl and butyl glucoside; sugar alcohols having 5 to 12 carbon atoms, such as sorbitol or mannitol, >sugars having 5 to 12 carbon atoms, such as glucose or sucrose; > Amino sugars, such as glucamine; > Dialcohol amines such as diethanolamine or 2-amino-1,3-propanediol. Preservatives Suitable preservatives are, for example, phenoxyethanol, formaldehyde solution, parabens, pentanediol or sorbic acid, and those sold under the name Surfacine®. known silver complexes and the other classes of substances listed in Annex 6, Parts A and B of the Cosmetics Ordinance. Perfume Oils and Flavors Perfume oils which may be mentioned are mixtures of natural and synthetic fragrances. Natural fragrances are extracts of flowers (lily, lavender, rose, jasmine, neroli, ylang ylang), stems and leaves (geranium, patchouli, petitgrain), fruits (aniseed, coriander, caraway, juniper), fruit peels (bergamot, lemon, orange ), roots (mace, angelica, celery, cardamom, costus, iris, camus), wood (pine, sand, guaiac, cedar, rosewood), herbs and grasses (tarragon, lemongrass, sage, thyme), needles and twigs (spruce, fir, pine, mountain pine), resins and balms (galbanum, elemi, benzoin, myrrh, olibanum, opoponax). Animal raw materials are also possible, such as civet and castoreum. Typical synthetic fragrance compounds are products of the ester, ether, aldehyde, ketone, alcohol and hydrocarbon type. Perfume compounds of the ester type are z. B. benzyl acetate, phenoxyethyl isobutyrate, p-tert. Butyl cyclohexyl acetate, linalyl acetate, dimethyl benzyl carbinyl acetate, phenyl ethyl acetate, linalyl benzoate, benzyl formate, ethyl methyl phenyl glycinate, allyl cyclohexyl propionate, styrallyl propionate and benzyl salicylate. The ethers include, for example, benzyl ethyl ether, the aldehydes z. B. the linear alkanals having 8 to 18 carbon atoms, citral, citronellal, citronellal lyloxyacetaldehyde, cyclamenaldehyde, hydroxycitronellal, lilial and bourgeonal, to the ketones z. The alcohols include anethole, citronellol, eugenol, isoeugenol, geraniol, linalool, phenylethyl alcohol and terpineol, and the hydrocarbons mainly include terpenes and balms. However, preference is given to using mixtures of different fragrances which together produce an appealing fragrance note. Essential oils of lower volatility, which are mostly used as aroma components, are also suitable as perfume oils, e.g. B. sage oil, chamomile oil, clove oil, lemon balm oil, mint oil, cinnamon leaf oil, lime blossom oil, juniper berry oil, vetiver oil, olibanum oil, galbanum oil, labolanum oil and lavandin oil. Preferred are bergamot oil, dihydromyrcenol, lilial, lyral, citronellol, phenylethyl alcohol, a-hexylcinnamaldehyde, geraniol, benzylacetone, cyclamenaldehyde, linalool, boisambrene forte, ambroxan, indole, hedione, sandelice, lemon oil, tangerine oil, orange oil, allylamyl glycolate, cyclovertal, lavandin oil, muscatel Sage oil, ss-damascone, bourbon geranium oil, cyclohexyl salicylate, Vertofix Coeur, Iso-E-Super, Fixolide NP, Evernyl, Iraldein gamma, phenylacetic acid, geranyl acetate, benzyl acetate, rose oxide, romililat, Irotyl and Floramat alone or in mixtures. Examples of flavors that can be used are peppermint oil, spearmint oil, anise oil, star anise oil, caraway oil, eucalyptus oil, fennel oil, lemon oil, wintergreen oil, clove oil, menthol and the like. Colorants Substances suitable and approved for cosmetic purposes can be used as colorants, as listed, for example, in the publication "Cosmetic Colorants" of the Colorants Commission of the German Research Foundation, Verlag Chemie, Weinheim, 1984, pp. 81-106. Examples are Cochineal Red A (C.I. 16255), Patent Blue V (C.I. 42051), Indigotine (C.I. 73015), Chlorophylline (C.I. 75810), Quinoline Yellow (C.I. 47005), Titanium Dioxide (C.I. 77891), Indanthrene Blue RS (C.I. 69800), and Madder Lake ( C.I. 58000). Luminol can also be present as a luminescent dye. These dyes are usually used in concentrations of 0.001 to 0.1% by weight, based on the mixture as a whole. The total proportion of auxiliaries and additives can be 1 to 50% by weight, preferably 5 to 40% by weight, based on the composition. The agents can be produced by customary cold or hot processes; the phase inversion temperature method is preferably used. EXAMPLES Example 1 30 g of dried leaves or stems of Myrothamnus flabellifolia were roughly crushed in a mortar, then transferred to a glass reactor and 300 ml of distilled water were added. The infusion was heated to approx. 80° C. and extracted at this temperature over a period of 1 hour with stirring. The mixture was then cooled to 20° C. and centrifuged at a speed of 5000 g for 15 min. The supernatant was separated from the residue by filtration (filter mesh: 0.45 µm) to obtain 190 ml of the extract, which had a dry residue of 1.6% by weight. After spray drying, a powder was obtained, the yield being 9.1% by weight based on the dry weight. Example 2 Example 1 was repeated, but the extraction was carried out with a methanol/water mixture (1:1). After spray drying, a powder was obtained, the yield being 18.5% by weight based on the dry weight. Example 3 Example 1 was repeated using leaves of Spirobolus cubensis (Hitchcock). A powder was obtained, the yield being around 10% by weight based on the dry weight. Example 4 Example 1 was repeated using leaves of Selaginella lepidophylla. A powder was obtained, the yield being around 10% by weight based on the dry weight. Example 5 Example 1 was repeated using leaves of Xerophyta retinervis. A powder was obtained, the yield being around 10% by weight based on the dry weight. Example 6 Example 1 was repeated, but the extraction was carried out using leaves of Craterostigma plantigineum with 300 ml of 96% by weight ethanol. The leaves were extracted twice as described above and the extracts pooled. The alcohol was then first removed at 45.degree. C. under reduced pressure and the residue was then dried at 50.degree. A powder was obtained in which the yield, based on the dry weight of the leaves used, was around 20% by weight. Example 7 1 kg of fresh baker's yeast Saccharomyces cerevisiae was suspended in 2 liters of water containing 50 mM NaC. The pH of the solution was adjusted to 7.5 with 2N NaOH solution, heated at 100° C. for 15 min and then cooled. The cells were destroyed at 800 bar using a discontinuous high-pressure homogenizer. The pH was adjusted to 4 with 2N sulfuric acid, and the suspension was again heated to 100° C. for 15 minutes and cooled. Insoluble parts were separated by centrifugation at 5600 g for 30 minutes, and the supernatant was filtered. The opalescent solution obtained was dried and 4.3% dry product was obtained. Example 8: Cell protective effect against UVA on human fibroblasts cultured in vitro Background: UVA rays penetrate into the dermis, where they lead to oxidative stress, which is demonstrated by lipoperoxidation of the cytoplasmic membranes. The lipoperoxides are broken down into malonaldialdehyde, which will cross-link many biological molecules such as proteins and nucleobases (enzyme inhibition or mutagenesis). Method: To carry out these tests, a defined culture medium (DMEM) containing the fibroblasts was inoculated with fetal calf serum and the plant extract (in the defined medium with 10% fetal calf serum) was added 72 hours after inoculation. The incubation took place at 37 C and a CO2 content of 5%. After 48 hours of incubation at 37 C and a CO2 content of 5%, the culture medium was replaced with a saline solution (physiological NaCl solution) and the fibroblasts were irradiated with a UVA dose (365 nm, 20 J/cm2; tubes: MAZDA FLUOR TFWN40). After termination of the irradiation, the MDA level (malonaldialdehyde level) in the supernatant sodium chloride solution was quantitatively determined by reaction with thiobarbituric acid. The protein content was determined according to Bradford's method with a Coomassie brilliant blue stain (Bradford; Analytical biochem., 72; 248-254; 1976). EMI26.1 <tb> <SEP> concentration <SEP> content <SEP> of <SEP> MDA <SEP> content <SEP> of <SEP> proteins <tb> <SEP> % by weight <SEP> [% <SEP> versus <SEP> control <SEP> [% <SEP> versus <SEP> control <tb> <SEP> extract <SEP> after <SEP> example <SEP> 1 <SEP> extract <SEP> after <SEP> example <SEP> 1 < tb> <SEP> control <SEP> without <SEP> UV0100 <tb> <SEP> UVA <SEP> (365 <SEP> nm) <SEP> 100 <SEP> 103 <SEP> (7) <tb> <SEP > UVA <SEP> + <SEP> Vitamin <SEP> E <SEP> 31 <SEP> (4) <SEP> 102 <SEP> (11) <tb> UVA <SEP> + <SEP> Extract <SEP> 0 , <SEP> 1% <SEP> 91 <SEP> (5) <SEP> 101 <SEP> (16) <tb> UVA <SEP> + <SEP> extract <SEP> 0.3 <SEP> % <SEP > 67 <SEP> (6) <SEP> 100 <SEP> (17) <tb> Table 1 Content of MDA and proteins for determining the cell protective effect against UVA (the standard deviation is in brackets) The results from the table show that the extracts of the plant Myrothamnus flabellifolia at a concentration of 0.3% by weight significantly reduce the level of MDA in human fibroblasts, which is induced by UVA rays. These results show a high capacity to reduce the harmful effects of oxidative stress on the skin. The protein content again illustrates the non-toxic effect of the extract. Example 9 Cell Protection Against UVB on Human Keratinocytes Grown in Vitro Method: The effect of UVB radiation was investigated on keratinocytes in vitro by determining the release of the cytoplasmic enzyme LDH (lactate dehydrogenase). This enzyme serves as a marker for cell damage. To carry out the tests, a defined medium (DMEM) containing fetal calf serum was inoculated with the keratinocytes and the plant extract (diluted with saline solution) was added 72 hours after inoculation. The keratinocytes were then irradiated with a UVB dose (50 mJ/cm2 tubes: DUKE FL40E). After a further 1 day of incubation at 37° C. and at 5% CO 2 , the LDH content in the supernatant was determined. The content of LDH (lactate dehydrogenase) was determined spectrophotometrically by determining the NADH content during the LDH-catalyzed conversion of pyruvate to lactate according to Bonnekoh's method. (Bonnekoh B et al.; Dermatol. Research; 282; 325-329; 1990). The number of adherent keratinocytes was determined using a DNA essay based on a fluorescence measurement of fluorochrome which binds to cellular DNA using the Desaufniers method. (Desaulniers D, et al.; Toxic). in vitro ; 12 ; 409-422; 1998) using a particle counter. The test was compared to a standard anti-inflammatory agent, acetylsalicylic acid. EMI27.1 <SEP> Extract <SEP> after <SEP> example <SEP> 1 <SEP> [% by weight] <SEP> number <SEP> keratinocytes <SEP> content <SEP> of <SEP> released <SEP > LDH <tb> <SEP> control <SEP> without <SEP> UV <SEP> 100 <SEP> 0 <tb> <SEP> UVB <SEP> 315 <SEP> nu <SEP> 25 <SEP> (3) <SEP> 100 <tb> UVB <SEP> + <SEP> acetylsalicylic acid <SEP> (0, <SEP> 03 <SEP> %) <SEP> 76 <SEP> (5) <SEP> 3 <SEP> (2 ) <tb> <SEP> UVB <SEP> + <SEP> Extract <SEP> 0, <SEP> 1 <SEP> % <SEP> 27 <SEP> 4 <SEP> 91 <SEP> 8 <tb> <SEP > UVB <SEP> + <SEP> Extract <SEP> 0.3 <SEP> % <SEP> 40 <SEP> (7) <SEP> 57 <SEP> (20 <tb> Table 2 Content of released LDH for determination the cell protective effect against UVB (the standard deviation is in brackets) The results of these tests show that the extracts show the effect of UVB radiation on the number of keratinocytes and on the content of released LDH at a concentration of 0.3 wt. The extracts described show the ability to reduce the damage to cell membranes caused by UVB radiation. Example 10 Cell Protection Against Heat Shock in Human Fibroblasts The heat shock in human fibroblasts was induced by increasing the incubation temperature from 37° C. to 45° C. for two hours. The number of living stressed cells was determined by the level of cellular adenosine triphosphate (ATP) and the level of lactate dehydrogenase (LDH). ATP level is a well known marker of cellular viability and altered level is a very sensitive test of cytotoxicity. The content was determined using the Vasseur method (Vasseur P. et al.; Environmental Pollution; 1; 167-175; 1980). The release of the high molecular weight cytoplasmic enzyme LDH is a sign of cell membrane damage and is a general marker of cell damage. The content of LDH (lactate dehydrogenase) was determined spectrophotometrically by determining the NADH content during the LDH-catalyzed conversion of pyruvate to lactate according to Bonnekoh's method. (Bonnekoh B et al.; Dermatol. Research; 282; 325-329; 1990). Method: To carry out these tests, a defined culture medium (DMEM) containing the fibroblasts was inoculated with fetal calf serum and the plant extract or the mixtures and preparations to be tested (in the defined medium with 10% fetal calf serum) were added 72 hours after inoculation. The incubation took place at 37 C and a CO 2 content of 5%. After 48 hours of incubation at 37 C and a CO 2 content of 5%, the cells were subjected to heat shock by increasing the incubation temperature from 37 C to 45 C for two hours. Another incubation of 24 hours at 37 C and a CO 2 content of 5% followed. The content of ATP was monitored by determining the amount of light in the enzymatic reaction between ATP and the complex of luciferin/luciferase. In addition to the extract from Example 1, a mixture containing water, glycerol, trehalose, polysaccharides from Tamarindus indica seeds and Myrothamnus flabellifolia extract and a preparation containing Myrothamnus flabellifolia extract according to Example 1 and yeast extract according to Example 7 in a ratio of 1: 1 at a concentration of 0.01% by weight tested. EMI29.1 <SEP> treatment <SEP> <SEP> level of <SEP> ATP <SEP> [%] <SEP> level <SEP> of <SEP> released <SEP> LDH <SEP> [%] <tb> <SEP> control <SEP> without <SEP> heat shock <SEP> 100 <SEP> 0 <tb> <SEP> control <SEP> with <SEP> heat shock <SEP> 17 <SEP> (5) <SEP> 100 < tb> <SEP> extract <SEP> after <SEP> example <SEP> 1 <SEP> with <SEP> 0.3 <SEP> wt% <SEP> + <SEP> heat shock <SEP> 77 <SEP> (4) <SEP> 16 <SEP> (7) <tb> <SEP> Named <SEP> mixture <SEP> with <SEP> 1 <SEP> % by weight <SEP> + <SEP> heat shock <SEP> 40 <SEP> 18 <SEP> 50 <SEP> 13 <tb> Preparation <SEP> from <SEP> extract <SEP> according to <SEP> example <SEP> 1 <SEP> and <SEP> example <SEP> 7 < SEP> 74 <SEP> 8 <tb> <SEP> (ratio <SEP> 1 <SEP> : <SEP> 1)/0, <SEP> 01 <SEP> wt% <SEP> + <SEP> heat shock < tb> Table 3 Content of released LDH and released ATP to determine the cell protective effect against heat shock (the standard deviation is in brackets) The harmful effect of heat shock on human fibroblasts could be shown by the reduced content of ATP and the increased content of released LDH. Treatment with Myrothamnus flabellifolia extract has shown cellular resistance to heat shock. At a concentration of 0.3% by weight, the cytotoxic effect of heat shock, determined by the ATP content and by the content of released LDH, could be almost completely eliminated. Example 11 Cell Protection Against Cold Shock in Human Lymph Cells The viability of stressed cells was examined in human lymph cells by a test with propidium iodide. Propidium iodide is not taken up into the cell by intact cells d. H. it does not penetrate through the intact cell wall. Only damage to the cell wall allows the fluorescent marker to penetrate into the cell. As a result, destroyed cells become fluorescent and uptake of the marker can be quantified by flow cytometry (cf. Lemaster JJ. et al.; Nature; 325; 78-81; 1987). Method: The lymph cells were cultured for one day in a standard medium “RPMI 1640 complete” from Sigma. The standard growth medium was then replaced by a medium which either served as a control medium or contained the mixture to be tested according to Example 10 containing water, glycerol, trehalose, polysaccharides from Tamarindus indica seeds and Myrothamnus flabellifolia extract and incubated for another day. The cold shock was induced by deep freezing at -20 C for 15 minutes. The test results were determined either after a 15 minute post-shock incubation at +20 C or after a 4 hour incubation at 37 C by flow cytometry according to the Lemaster method. The values for lymph cells without cold shock and addition of the mixture at 0.1% by weight were determined at the same incubation times in each case, but the cells were not exposed to a 15-minute cold shock. EMI30.1 Treatment <SEP> propium <SEP> iodide positive <SEP> cells <SEP> [%] <SEP> propium <SEP> iodide positive <SEP> cells <SEP> [%] <tb> <SEP> 15 <SEP> minutes <SEP> after <SEP> the <SEP> cold shock <SEP> 4 <SEP> hours <SEP> after <SEP> the <SEP> cold shock <tb> LyC <SEP> without <SEP> cold shock < SEP> 11, <SEP> 2 <SEP> (0.4) <SEP> 9.9 <SEP> (0.17) <tb> LyC <SEP> + <SEP> mix <SEP> with <SEP> 0 , <SEP> 1 <SEP> wt% <SEP> 12.4 <SEP> (0.23) <SEP> 6.7 <SEP> (0.17) <tb> LyC <SEP> + <SEP > with <SEP> cold shock <SEP> 15.2 <SEP> (0.57) <SEP> 24.3 <SEP> (6.75) <tb> Lyc <SEP> C <SEP> + <SEP> mixture <SEP> with <SEP> 0.3 <SEP> wt% <SEP> + <SEP> cold shock <SEP> 12 <SEP> (1.09) <SEP> 11.2 <SEP> (0.86 ) <tb> LyC = lymph cells Table 4 Content of fluorescent cells for determining the cell protective effect against cold shock (the standard deviation is in brackets) A 15-minute cold shock period after an incubation period of 4 hours shows an increase in destroyed cells that express the fluorescent marker have recorded. Treatment with a mixture containing water, glycerin, trehalose, polysaccharides from Tamarindus indica seeds and Myrothamnus flabellifolia extract significantly increased the viability of lymph cells after cold shock. Example 12 Cell Protection Against Osmotic Stress on Red Blood Cells (Erythrocytes) The resistance against osmotic stress or “osmotic shock” on the membrane-stabilizing activity was tested on human red blood cells by bringing them into contact with a hypoosmotic medium. Method: First, a solution of buffered hypo-osmotic salt solution containing 0.24 g/l NaCl was prepared and the red blood cells were incubated in this solution at room temperature for 60 minutes. The mixture to be tested containing water, glycerin, trehalose, polysaccharides from Tamarindus indica seeds and Myrothamnus flabellifolia extract was added in different concentrations. However, as a control, the cells were incubated in the osmotic salt solution without the mixture to be tested. The cells were then centrifuged at 3000 rpm for 10 min. The intensity of the hemolysis that started (escape of hemoglobin from the erythrocytes) was monitored spectrophotometrically at an optical density of 412 nm. EMI31.1 Treatment <SEP> intensity <SEP> on <SEP> released <SEP> hemoglobin <tb> control <SEP> with <SEP> osmotic <SEP> shock <SEP> 100 <tb> named <SEP> mixture <SEP > with <SEP> 1 <SEP> wt% <SEP> + <SEP> osmotic <SEP> shock <SEP> 91 <SEP> (6) <tb> Named <SEP> mixture <SEP> with <SEP> 3 <SEP> wt% <SEP> + <SEP> osmotic <SEP> shock <SEP> 45 <SEP> (6) <tb> Table 5 Intensity of released hemoglobin to determine the cell protective effect against osmotic shock (in brackets where the standard deviation is found) The tests demonstrate a cell-protecting activity of the tested mixture containing water, glycerol, trehalose, polysaccharides from Tamarindus indica seeds and Myrothamnus flabellifolia extract against osmotic shock. At a concentration of 3% by weight of the solution, this effect can be detected significantly by a reduced release of hemoglobin from the stressed erythrocytes. Example 13 Test for Moisture Regulation of the Skin Background: The horny layer (the stratum corneum) is found in the epidermis of human skin. The stratum corneum is a dielectric medium of low electrical conductivity. The water content leads to increased dielectric conductivity and the determination of the dielectric conductivity of the stratum corneum can thus serve as a measure of the degree of moisture in human skin. The increase in the dielectric conductivity of the stratum corneum reflects an increased degree of moisture in the human skin. Method : Normal skin samples obtained from plastic surgery were used for this test. The stratum corneum from these skin samples was stored in chambers with a defined relative humidity (44%, saturated solution of potassium carbonate) and standardized. Each sample of stratum corneum was tested comparatively under four conditions. 1) without treatment ; 2) treatment with placebo; 3) Treatment with a preparation consisting of a hydrogel (Hydrogel LS from Laboratoire Sérobiologique LS) containing 1.125% by weight My rothamnus flabellifolia extract. 4) Treatment with a preparation consisting of a hydrogel (Hydrogel LS from Laboratoire Sérobiologique LS) containing 3% by weight of a mixture containing water, glycerol, trehalose, polysaccharides from Tamarindus indica seeds and Myrothamnus flabellifolia extract. The hydrogel (Hydrogel LS from Laboratoire Sérobiologique LS) without the preparation described, i.e. without plant extract, served as a placebo. The moisture-regulating activity of the preparation described above was determined as a percentage increase in conductivity compared to the placebo treatment. A dose-dependent moisture-regulating activity can be seen from the results. EMI32.1 <tb> Type <SEP> of <SEP> treatment <SEP> before <SEP> de <SEP> 30 <SEP> min <SEP> 1 <SEP> : <SEP> hour. <SEP> 2 <SEP> hours <SEP> 4 <SEP> hours <SEP> 6 <SEP> hours <SEP> 2 <SEP> hours <tb> <SEP> treatment <SEP> = <tb> control <SEP> 22, <SEP> 5 <SEP> (4, <SEP> 4) <SEP> 22, <SEP> 1 <SEP> (2, <SEP> 7) <SEP> 21, <SEP> 9 <SEP> ( 3, <SEP> 8) <SEP> 23, <SEP> 9 <SEP> (4, <SEP> 4) <SEP> 20, <SEP> 3 <SEP> (3, <SEP> 3) <SEP> 22, <SEP> 9 <SEP> (3, <SEP> 9) <SEP> 20, <SEP> 0 <SEP> (3, <SEP> 0) <tb> check <SEP> ! <SEP> ie <SEP> 22.5 <SEP> (4.4) <SEP> 22.1 <SEP> (2.7) <SEP> 21.9 <SEP> (3.8) <SEP> 23 .9 <SEP> (4,4) <SEP> 20.3 <SEP> (3,3) <SEP> 22.9 <SEP> (3,9) <SEP> 20.0 <SEP> (3, 0) <tb> Placebo <SEP> 23.7 <SEP> (1.8) <SEP> 59.1 <SEP> (2.4) <SEP> 41.3 <SEP> (2.7) <SEP > 34.9 <SEP> (2.1) <SEP> 33.6 <SEP> (2.4) <SEP> 33.0 <SEP> (3.0) <SEP> 32.0 <SEP> ( 1.7) <tb> treatment <SEP> after <SEP> 3) <SEP> 22.9 <SEP> (1.6) <SEP> 82.4 <SEP> (11.9) <SEP> 50, 7 <SEP> (2.8) <SEP> 40.1 <SEP> (3.0) <SEP> 35.1 <SEP> (2.5) <SEP> 32.6 <SEP> (2.4 ) <SEP> 31.8 <SEP> (1.8) <tb> treatment <SEP> after <SEP> 4) <SEP> 24.4 <SEP> (2.8) <SEP> 111, <SEP> 1 <SEP> (6.5) <SEP> 80.7 <SEP> (4.2) <SEP> 67.9 <SEP> (4.6) <SEP> 56.9 <SEP> (4.3 ) <SEP> 53.5 <SEP> (4.4) <SEP> 54.6 <SEP> (4.7) <tb> Table 1 Moisture control effect determined by measurement of dielectric conductivity (in pS) ; Mean value from 18 investigations (the standard deviation is in brackets) Example 14 To determine the polysaccharide composition, the extracts according to Examples 1 and 2 were subjected to thin-layer chromatography. Solvent: acetone-butanol-phosphate buffer/pH=7:50:40:10 v/v) staining Nl-(naphthyl)ethylenediamine dihydrochloride (100 C; 10-15 min) FIG. 1 shows the chromatogram for example 14 The numbering below of the chromatogram has the following meaning: 1 Analytical extract of Myrothamnus flabellifolia 2 : Analytical extract of Myrothamnus flabellifolia 3 : Myrothamnus flabellifolia extract according to Example 1 at 1% by weight 4 : Myrothamnus flabellifolia extract according to Example 2 at 1% by weight 5 : Trehalose Standard 0.1% by weight 6: rhamnose Standard 0.1% by weight 7: glucose Standard 0.1% by weight Example 15 To determine the free-radical scavengers, the extracts according to Examples 1 and 2 were subjected to a further thin-layer chromatography. Solvent : toluene-ethyl acetate-formic acid-water, 46:84:24:15 v/v). Staining : Neu + PEG (flavones), DMCA (tannins, anthocyanins), 100 C ; 10-15 min. Figure 2 shows the chromatogram for example 15 and the numbering below the chromatogram has the following meaning: 1: Myrothamnus flabellifolia extract according to example 1 at 1% by weight 2: Myrothamnus flabellifolia extract according to example 2 at 1% by weight -% 3 : Analytical methanol extract 80% v/v at 7.5% v/v according to example 1 4 : Analytical methanol extract 80% v/v at 7.5% v/v according to example 2 5 : Standard mixture : rutin + isoquercitrin 6 : standard mixture : quercetin+quercetol Examples 16 and 17 Table 7 below shows two so-called “survival fractions” which were produced by mixing active components of the extracts according to the invention. It was produced by mixing the xyloglucans, the extracts and the glycerine at 70° C.; the remaining ingredients were added later. Table 7 Survival Fractions EMI33.1 Composition <SEP> Ex. <SEP> 16 <SEP> Ex17 <tb> Tamarinds <SEP> Xyloglucans <SEP> 16.7 <SEP> 16 <SEP> 0 <tb> Extract <SEP> Ex <SEP> 1 <SEP> 37, <SEP> 5 <tb> Extract <SEP> Ex. <SEP> 6-37, <SEP> 5 <tb> Glycerol <SEP> 40.0 <SEP> 40 <SEP > 0 <tb> trehalose <SEP> 2, <SEP> 3 <SEP> 2, <SEP> 0 <tb> preservative <SEP> 3, <SEP> 5 <SEP> 3, <SEP> 5 <tb> water <SEP> ad <SEP> 100 <tb> From the above results of the activity determination examples, it is clear that the examined and tested extracts of the Myrothamnus flabellifolia plant have the following abilities: 1. Reduction of the lipo induced by UVA rays in human fibroblasts degree of peroxidation ; 2. Reduction of cell damage induced by UVB on human keratinocytes; 3. Cell protective effect against heat shock, cold shock and osmotic shock and thus an activity to protect the skin against harmful environmental influences. 4. a preparation containing extracts from the plant Myrothamnus flabellifolia showed clear moisture-regulating abilities. Table 2 Cosmetic preparations (water, preservatives ad 100% by weight) EMI34.1 <tb> Composition <SEP> (INCI) <SEP> 1 <SEP> 2 <SEP> 3 <SEP> 4 <SEP> 5 <SEP > 6 <tb> Emu) <SEP> gade@ <SEP> SE5, <SEP> 0 <SEP> 5.0 <SEP> 5.0 <SEP> 4, <SEP> 0 <SEP> - <SEP> <tb> Glyceryl <SEP> Sterate <SEP> (and ) <SEP> Ceteareth <SEP> 12/20 <SEP> (and) <SEP> Cetearyl <SEP> Alcohol <tb> <SEP> (and)Cetyl <SEP> Palmitate <tb> Eumulgin# <SEP> Bi <SEP > - <SEP> - <SEP> - <SEP> 1.0 <SEP> - <SEP> <tb> Ceteareth-12 <tb> Lameform# <SEP> TGI <SEP> - <SEP> - <SEP> - <SEP> - <SEP> 4.0 <SEP> <tb> Polyglyceryl-3 <SEP> Isostearate <tb> Dehymuls# <SEP> PGPH-----4, <SEP> 0 <tb> Polyglyceryl-2 < SEP> Dipolyhydroxystearate <tb> Monomulse <SEP> 90-018 <SEP> 2, <SEP> 0 <tb> Glyceryl <SEP> Oleate <tb> Cetiol# <SEP> HE-----2, <SEP> 0 <tb> PEG-7 <SEP> Glyceryl <SEP> Cocoate <tb> Cetiol# <SEP> OE <SEP> - <SEP> - <SEP> - <SEP> - <SEP> 5, <SEP> 0 <SEP > 6.0 <tb> dicaprylyl <SEP> ether <tb> cetiol# <SEP> PGL <SEP> - <SEP> - <SEP> - <SEP> 3, <SEP> 0 <SEP> 10, <SEP> 0 <SEP> 9.0 <tb> Hexyldecanol <SEP> (and) <SEP> Hexyldecyl <SEP> Laurate <tb> Cetiols <SEP> SN <SEP> 3.0 <SEP> 3.0 <SEP> 3, 0 <SEP> - <SEP> - <SEP> <tb> CetearylIsononanoate <tb> Cetiole <SEP> V <SEP> 3.0 <SEP> 3.0 <SEP> 3.0 <tb> DecylOleate <tb> Myritol # <SEP> 318---3, <SEP> 0 <SEP> 5.0 <SEP> 5.0 <tb> CocoCaprylate <SEP> Caprate <tb> Bees <SEP> Wax <SEP> 7, <SEP> 0 <SEP> 5, <SEP> 0 <tb> Nutrilan@ <SEP> elastin <SEP> E20 <SEP> 2.0 <SEP> 2.0--- <tb> hydrolyzed elastin <tb> extract <SEP> according to <SEP> example <SEP> 1 <SEP> 0, 1 <SEP> - <SEP> - <SEP> - <SEP> - <SEP> <tb> Extract <SEP> according to <SEP> Bs. <SEP> 2 <SEP> - <SEP> 0.1 <SEP> - < SEP> - <SEP> - <SEP> <tb> Extract <SEP> emä# <SEP> Ex. <SEP> 3 <SEP> - <SEP> - <SEP> 0.1 <SEP> - <SEP> - <SEP> <tb> Extract <SEP> according to <SEP> Example <SEP> 4 <SEP> - <SEP> - <SEP> - <SEP> 0.1 <SEP> - <SEP> <tb> Extract < SEP> according to <SEP> Ex. <SEP> 5----0 <SEP> 1 <tb> Extract <SEP> according to <SEP> Bs. <SEP> 6 <SEP> - <SEP> - <SEP> - <SEP> - <SEP> - <SEP> 0.1 <tb> Nutrillan# <SEP> I-50 <SEP> - <SEP> - <SEP> 2.0 <SEP> - <SEP> - <SEP> <tb> H <SEP> drol <SEP> zed <SEP> Colla <SEP> en <tb> Gluadin# <SEP> AGP <SEP> - <SEP> - <SEP> - <SEP> 0.5 <SEP> - <SEP> <tb> Hvdrolvzed <SEP> Wheat <SEP> Gluten <tb> Gluadin# <SEP> WK <SEP> - <SEP> - <SEP> - <SEP> - <SEP> 0, <SEP> 5 <SEP> 0.5 <tb> Sodium <SEP> Cocoyl <SEP> Hydrolyzed <SEP> Wheat <SEP> Protein <tb> Highcareen# <SEP> GS <SEP> 1.0 <SEP> 1.0 <SEP> 1.0 <SEP> 1.0 <SEP> 1.0 <SEP> 1.0 <tb> Betaglucan <tb> Hydagen# <SEP> CMF <SEP> 1.0 <SEP> 1.0 <SEP> 1 .0 <SEP> 1.0 <SEP> 1.0 <SEP> 1.0 <tb> Chitosan <tb> Magnesium <SEP> Sulfate <SEP> Hepta <SEP> Hydrate <SEP> - <SEP> - <SEP > - <SEP> - <SEP> 1.0 <SEP> 1.0 <tb> glycerol <SEP> (86 <SEP> wt% <SEP> ig) <SEP> 3, <SEP> 0 <SEP > 3 <SEP> 0 <SEP> 3.0 <SEP> 5 <SEP> 0 <SEP> 5 <SEP> 0 <SEP> 3, <SEP> 0 <tb> (1,2) soft cream, (3,4) Moisturizing emulsion, (5,6) night cream Table 2 Cosmetic preparations (water, preservative ad 100% by weight)-continued EMI35.1 Composition <SEP> (INCI) <SEP> 7 <SEP> 8 <SEP> 9 <SEP> 10 <SEP> 11 <SEP> 12 <tb> Emu <SEP> ! <SEP> gade@ <SEP>SE5, <SEP>0 <SEP>5.0 <SEP>5.0 <SEP>4.0- Glyceryl <SEP> Sterate <SEP> (and) <SEP> Ceteareth <SEP> 12/20 < SEP> (and) <SEP> Cetearyl <SEP> Alcohol <tb> <SEP> (and) <SEP> Cetyl <SEP> Palmitate <tb> Eumulgin <SEP> B1---1, <SEP> 0- Ceteareth- 12 <tb> Lameform# <SEP> TGI <SEP> - <SEP> - <SEP> - <SEP> - <SEP> 4.0 <SEP> Polyglyceryl-3 <SEP> Isostearate <tb> Dehymuls# <SEP> PGPH <SEP> - <SEP> - <SEP> - <SEP> - <SEP> - <SEP> 4, <SEP> 0 <tb> Polyglyceryl-2 <SEP> Dipolyhydroxystearate <tb> Monomuls# <SEP> 90- O <SEP> 18 <SEP> - <SEP> - <SEP> - <SEP> - <SEP> 2.0 <SEP> Glyceryl <SEP> Oleate <tb> Cetiol# <SEP> HE <SEP> - <SEP > - <SEP> - <SEP> - <SEP> - <SEP> 2, <SEP> 0 <tb> PEG-7 <SEP> Glyceryl <SEP> Cocoate <tb> Cetiol# <SEP> OE <SEP> - <SEP> - <SEP> - <SEP> - <SEP> 5, <SEP> 0 <SEP> 6,0 <tb> Dicaprylyl <SEP> Ether <tb> Cetiol# <SEP> PGL <SEP> - <SEP > - <SEP> - <SEP> 3, <SEP> 0 <SEP> 10.0 <SEP> 9.0 <tb> Hexyldecanol <SEP> (and) <SEP> Hexyldecyl <SEP> Laurate <tb> étiole < SEP> SN <SEP> 3.0 <SEP> 3.0 <SEP> 3, <SEP> 0 <SEP> - <SEP> - <SEP> Cetearyl <SEP> Isononanoate <tb> Cetiol# <SEP> V < SEP> 3.0 <SEP> 3.0 <SEP> 3.0-- Decyl <SEP> Oleate <tb> Myritol# <SEP> 318 <SEP> - <SEP> - <SEP> - <SEP> 3, <SEP> 0 <SEP> 5.0 <SEP> 5.0 <tb> Coco <SEP> Caprylate <SEP> Caprate <tb> Bees <SEP> Wax <SEP> - <SEP> - <SEP> - <SEP > - <SEP> 7.0 <SEP> 5 <SEP> 0 <tb> Nutrilan# <SEP> Elastin <SEP> E20 <SEP> 2.0 <SEP> 2, <SEP> 0 <SEP> - <SEP > - <SEP> - <SEP> H <SEP> drol <SEP> zed <SEP> elastin <tb> preparation <SEP> according to <SEP> example <SEP> 16 <SEP> 0, <SEP> 1 <tb > Preparation <SEP> according to <SEP> Example <SEP> 17 <SEP> 1 <tb> octulose <SEP> - <SEP> - <SEP> 0.1 <SEP> - <SEP> - <SEP> arbutin < SEP>0,<SEP>1 <tb>tamarinds <SEP>xyloglucans <SEP>0,<SEP>1 <tb>abscisic acid0,<SEP>1 <tb>nutrilane <SEP>I-50 <SEP>2,< SEP> 0 <tb> H <SEP> drol <SEP> zed <SEP> Colla <SEP> en <tb> Gluadin@ <SEP> AGP-0, <SEP> 5 Hydrolyzed <SEP> Wheat <SEP> Gluten <tb> Gluadin# <SEP> WK <SEP> - <SEP> - <SEP> - <SEP> - <SEP> 0, <SEP> 5 <SEP> 0.5 <tb> Sodium <SEP> Coco <SEP> Hydrolyzed <SEP> Wheat <SEP> Protein <tb> Highcareen@ <SEP> GS <SEP> 1.0 <SEP> 1.0 <SEP> 1.0 <SEP> 1.0 <SEP> 1.0 <SEP> 1.0 <tb> Betaglucan <tb> Hydagen®< SEP> CMF <SEP> 1, <SEP> 0 <SEP> 1.0 <SEP> 1.0 <SEP> 1.0 <SEP> 1.0 <SEP> 1.0 <tb> Chitosan <tb> Magnesium <SEP> sulfates <SEP> hepta <SEP> hydrates <SEP> - <SEP> - <SEP> - <SEP> - <SEP> 1.0 <SEP> 1.0 <tb> glycerol <SEP> (86 < SEP> wt% <SEP> ig) <SEP> 3.0 <SEP> 3.0 <SEP> 3.0 <SEP> 5, <SEP> 0 <SEP> 5, <SEP> 0 <SEP> 3, <SEP> 0 <tb> (7,8) soft cream, (9,10) moisturizing emulsion, (11,12) night cream
Claims
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0100492A FR2819414A1 (en) | 2001-01-15 | 2001-01-15 | COSMETIC AND / OR PHARMACEUTICAL PREPARATIONS COMPRISING EXTRACTS FROM PLANTS RESOURCING |
FR0100492 | 2001-01-15 | ||
PCT/EP2002/000053 WO2002055048A1 (en) | 2001-01-15 | 2002-01-05 | Cosmetic and/or pharmaceutical preparations |
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EP1351662A1 true EP1351662A1 (en) | 2003-10-15 |
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EP02706696A Withdrawn EP1351663A1 (en) | 2001-01-15 | 2002-01-05 | Cosmetic and/or pharmaceutical preparations |
EP02703537A Withdrawn EP1351662A1 (en) | 2001-01-15 | 2002-01-05 | Cosmetic and/or pharmaceutical preparations |
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EP02706696A Withdrawn EP1351663A1 (en) | 2001-01-15 | 2002-01-05 | Cosmetic and/or pharmaceutical preparations |
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US (3) | US20040081714A1 (en) |
EP (2) | EP1351663A1 (en) |
JP (2) | JP2004520338A (en) |
FR (1) | FR2819414A1 (en) |
WO (2) | WO2002055048A1 (en) |
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-
2001
- 2001-01-15 FR FR0100492A patent/FR2819414A1/en not_active Withdrawn
-
2002
- 2002-01-05 JP JP2002555785A patent/JP2004520338A/en active Pending
- 2002-01-05 JP JP2002555784A patent/JP2004529866A/en active Pending
- 2002-01-05 US US10/250,870 patent/US20040081714A1/en not_active Abandoned
- 2002-01-05 WO PCT/EP2002/000053 patent/WO2002055048A1/en active Search and Examination
- 2002-01-05 EP EP02706696A patent/EP1351663A1/en not_active Withdrawn
- 2002-01-05 WO PCT/EP2002/000055 patent/WO2002055049A1/en active Application Filing
- 2002-01-05 EP EP02703537A patent/EP1351662A1/en not_active Withdrawn
- 2002-01-05 US US10/250,814 patent/US20040109880A1/en not_active Abandoned
-
2006
- 2006-10-12 US US11/546,588 patent/US20070134193A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1351663A1 (en) | 2003-10-15 |
FR2819414A1 (en) | 2002-07-19 |
WO2002055049A1 (en) | 2002-07-18 |
WO2002055048A1 (en) | 2002-07-18 |
JP2004520338A (en) | 2004-07-08 |
JP2004529866A (en) | 2004-09-30 |
US20040109880A1 (en) | 2004-06-10 |
US20070134193A1 (en) | 2007-06-14 |
US20040081714A1 (en) | 2004-04-29 |
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