Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q15/00—Anti-perspirants or body deodorants
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
  • A61K8/0208—Tissues; Wipes; Patches

Definitions

• the present invention relates to cosmetic or dermatological antiperspirant wipes.
• Body odors in their original sense are used for social communication.
• special substances pheromones
• scent glands have a significant influence on sexual, territorial and aggressive behavior in the animal world or are an expression of individuality or ranking.
• this type of communication has lost much of its importance for humans, as the comparatively poor performance of the human sense of smell indicates.
• Body odor is seen in modern western societies as obtrusive, repulsive and neglected.
• cosmetic or dermatological deodorants / antiperspirants offers a way to counteract unpleasant body odor.
• Body odor arises when the odorless fresh sweat is broken down by microorganisms.
• the gram-positive bacteria break down the sebum, protein substances and the dissolved components of the sweat. This frees up odor-intensive short-chain fatty acids and amines.
• Apocrine sweat in particular, transports a series of microorganisms to the surface of the skin via the sebaceous glands and hair follicles, which very soon intervene in the decomposition.
• there is also a certain resident microorganism population on the skin which, supplemented by transient microorganisms from the environment, influences the breakdown of sweat.
• the usual cosmetic deodorants and / or antiperspirants are based on different active principles.
• the usual active ingredients used in deodorants and / or antiperspirants for example, have antimicrobial properties that prevent the microbial decomposition of fresh sweat.
• a deodorizing effect can also be achieved by enzyme-inhibiting but not antimicrobial substances and / or by ion exchangers.
• Cation exchanger z. B. are said to absorb ammonia, indole and similar odors.
• Active ingredients with antiperspirant properties are those that reduce or completely suppress sweating in the human body, the effect being topical when applied topically.
• the effectiveness of deodorant or antiperspirant active ingredients also depends, among other things, on the formulation base into which they are incorporated and on the auxiliaries and / or additives used in the production.
• antiperspirants primarily inhibit sweat secretion, but generally also have a certain antibacterial effect. They have a blocking effect on the part of the execution duct of the sweat glands that leads through the stratum corneum. They constrict or close the sweat glands so that sweating is completely or partially suppressed.
• Antiperspirants are used primarily in the form of aqueous solutions and as powders or granules (dry sprays). Other forms of preparation, such as. B. alcoholic solutions, emulsions, creams, ointments and the like are possible in principle, but sometimes difficult to formulate stable.
• microemulsions with a significant content of antiperspirant active ingredients such as aluminum chloride, aluminum chlorohydrate and / or aluminum zirconium salts.
• antiperspirant active ingredients such as aluminum chloride, aluminum chlorohydrate and / or aluminum zirconium salts.
• Such formulations are commercially available, for example, in the form of pump sprays.
• Antiperspirants and / or deodorants are offered in different forms of application, e.g. B. as aerosols, pump sprays, rollers or pens, which naturally differ greatly in their composition.
• B. As aerosols, pump sprays, rollers or pens, which naturally differ greatly in their composition.
• the development of antiperspirants and / or deodorants today focuses on gels, pump sprays, rollers and pens.
• Cosmetic or dermatological antiperspirants reduce sweat by 20 to 60%. The rule here is that the effectiveness increases the higher the active substance concentration.
• Cosmetic or dermatological antiperspirants generally contain the active ingredient (s) in a concentration of 10 to 15% by weight, depending on the desired sweat reduction up to 20% by weight or more.
• antiperspirant products An important quality feature of antiperspirant products is the feeling on the skin that arises after the application under the armpits.
• the aluminum compounds known as antiperspirant agents when used in the form of cosmetic or dermatological preparations, tend to cause a sticky feeling after application to the skin and drying or drawing in of the formulations, which in individual cases can lead to the products not being marketable because they are not accepted by consumers or judged negatively.
• Antiperspirant wipes are also known per se.
• B the British patent application GB 2 110 928 A, the combination of antiperspirant cosmetic tissues and corresponding sealed packaging, the antiperspirant preparation consisting of a 25% solution of aluminum chloride and 3% Hydagen deodorant in an ethanolic base.
• this document could not show the way to the present invention.
• the customary commercially available antiperspirant products are generally distinguished by the fact that the cosmetic or dermatological preparation does not come into contact with the hands of the user.
• the object of the invention was therefore to remedy the disadvantages of the prior art and to find antiperspirant impregnation solutions and / or antiperspirant wipes which have a good effect, have good skin compatibility and do not leave or leave a sticky feeling on the skin and in particular on the hands . cause.
• Another object of the present invention was to develop preparations which are suitable as a basis for cosmetic or dermatological antiperspirant wipes and which are distinguished by good skin tolerance.
• antiperspirant wipes included a carrier material made of woven and / or non-woven, flexible material which is impregnated with a microemulsion, the microemulsion, based in each case on the total weight of the microemulsion, (a) 0.3 to 2.5% by weight of one or more Glyceryl esters, (b) 0.1 to 1% by weight of one or more alkyl alcohols,
• (d) contains at least 4% by weight of one or more antiperspirant active ingredients, the total content of the substances according to (a), (b) and (c) being at least 2% by weight remedy the disadvantages of the prior art.
• Carrier materials preferred according to the invention are dry cloths which are constructed, for example, from materials such as paper and / or a wide variety of mixtures of natural or synthetic fibers. Such cloths can possibly be embossed advantageously (macroscopically).
• Advantageous wipes exist e.g. B. from water jet consolidated and / or water jet embossed nonwovens (spunlaced material). If the nonwovens have embossments in the sense of the present invention, they can have any desired pattern. The selection to be made depends on the one hand on the impregnation to be applied and on the other hand on the special field of application in which the subsequent cloth is to be used.
• Woven cloths and papers are also advantageous carrier materials for the purposes of the present invention.
• Cross direction> 20 preferably> 30 in the impregnated state
• machine direction> 4 preferably> 60
• Transverse direction preferably> 20
• the stretchability of wipes according to the invention is preferably 15% to 100%, preferably in the machine direction when dry
• Transverse direction 40% to 120%, preferred
• Transverse direction 40% to 120%, preferred
• the cloth has a weight of 35 to 120 g / m 2 , preferably of 60 to 80 g / m 2 (measured at 20 ° C ⁇ 2 ° C and with a humidity of the room air of 65% ⁇ 5% for 24 hours).
• the thickness of the carrier material is preferably 0.4 mm to 1.5 mm, in particular 0.6 mm to 0.9 mm.
• All organic and inorganic fiber materials on a natural and synthetic basis can generally be used as starting materials for woven and non-woven carrier materials.
• Examples include viscose, cotton, jute, hemp, sisal, silk, wool, polypropylene, polyester, polyethylene terephthalate (PET), aramid, nylon, polyvinyl derivatives, polyurethanes, polylactide, polyhydroxyalkanoate, cellulose esters and / or polyethylene as well as mineral fibers such as glass fibers or carbon fibers cited.
• PET polyethylene terephthalate
• aramid nylon
• polyvinyl derivatives polyurethanes
• polylactide polyhydroxyalkanoate
• cellulose esters polyhydroxyalkanoate
• cellulose esters and / or polyethylene
• mineral fibers such as glass fibers or carbon fibers cited.
• the present invention is not limited to the materials mentioned, but a large number of other fibers can be used for forming the cloth.
• the fibers consist as much as possible of 100% viscose. Fibers made from high-strength polymers such as polyamide, polyester and / or highly stretched polyethylene are also particularly advantageous.
• the fibers can also be colored in order to emphasize and / or increase the optical attractiveness of the cloth.
• the fibers can additionally contain UV stabilizers and / or preservatives.
• the fibers used to form the cloth preferably have a water absorption rate of more than 60 mm / [10 min] (measured with the EDANA test 10.1-72), in particular more than 80 mm / [10 min].
• the fibers used to form the cloth then preferably have a water absorption capacity of more than 5 g / g (measured with the EDANA test 10.1-72), in particular more than 8 g / g.
• glyceryl esters according to the invention are e.g. B. the monoesters of glycerol, in particular those which are distinguished by the following structural formula:
• R represents a branched or unbranched, saturated or unsaturated carbon radical having 12 to 24 carbon atoms.
• Glyceryl stearate is particularly preferred for the purposes of the present invention.
• Branched or unbranched alkyl alcohols having 10 to 20 carbon atoms in particular myristyl alcohol (tetradecanol), cetyl alcohol (hexadanol) and / or stearyl alcohol (octadecanol) are advantageous according to the invention.
• myristyl alcohol tetradecanol
• cetyl alcohol hexadanol
• stearyl alcohol octadecanol
• cetearyl alcohol a white to pale yellow colored, waxy mass composed of approximately equal parts of cetyl alcohol and stearyl alcohol, is particularly advantageous.
• Alkyl alcohol polyethylene glycol ethers are also referred to as polyoxyethylene (n) alkyl ethers, the number n indicating the number of oxyethylene units.
• Alkyl alcohol polyethylene glycol ethers which are advantageous according to the invention have 8 to 24 oxyethylene units and the alkyl group carries 12 to 24 carbon atoms.
• ceteareth such as ceteareth-12 (polyoxyethylene (12) cetylstearyl ether) and / or ceteareth-20 (polyoxyethylene (20) cetylstearyl ether).
• glyceryl stearate with ceteareth-12 and cetearyl alcohol, which may also advantageously contain cetyl palmitate, in particular those available under the trade name Emulgade SE from Cognis.
• An advantageous ceteareth-20 according to the invention is that available from Cognis under the trade name Eumulgin B2.
• formulations according to the present invention may contain further emulsifiers. It is preferable to use emulsifiers which are suitable for the preparation of customary emulsions, which may be present either individually or in any combination with one another.
• Preferred antiperspirant active ingredients for the purposes of the present invention are aluminum salts, such as, for example, aluminum chloride, aluminum chlorohydrate, nitrate, sulfate, acetate, etc.
• Zinc, magnesium and zirconium compounds are also advantageous according to the invention.
• the partially neutralized aluminum hydroxychlorides and zirconium / aluminum mixed salts are particularly advantageous for the purposes of the present invention.
• antiperspirant agents in the sense of the present invention are e.g. B. quaternary ammonium compounds of the general structural formula
• R 1 and R 2 independently represent methyl or ethyl groups
• R 3 is selected from the group of alkyl radicals with 1 to 18 carbon atoms
• R 4 is selected from the group consisting of alkyl radicals with 8 to 18 carbon atoms and the aralkyl radicals 7 to 18 carbon atoms is formed
• R 5 is selected from the group of alkyl radicals having 10 to 18 carbon atoms.
• X " represents an inorganic or organic anion, for example a halide (e.g. chloride or bromide), also an inorganic oxo element anion (of which in particular sulfate, carbonate, phosphate, borate and aluminate) and an alkyl sulfate (in particular Ethyl sulfate) or e.g. a lactate, acetate, benzoate, propionate, tartrate, citrate and others.
• a halide e.g. chloride or bromide
• an inorganic oxo element anion of which in particular sulfate, carbonate, phosphate, borate and aluminate
• alkyl sulfate in particular Ethyl sulfate
• Preferred according to the invention are benzalkonium chloride (N-alkyl-N, N-dimethylbenzylammonium chloride), cetrimonium bromide (N-hexadecyl-NNN-trimethylammonium bromide), cetyltrimethylammonium bromide, mecetronium ethyl sulfate (N-hexadecyl-N-ethyl sulfonate, N ), N, N-didecyl-N, N-dimethylammonium chloride and / or N, N-dioctyl-N, N-dimethylammonium chloride.
• substances selected from the group of benzyltrialkylammonium chlorides or bromides such as, for example, benzyldimethylstearylammonium chloride, are advantageously used as antiperspirant agents.
• Antiperspirant agents preferred according to the invention are also lauryl or cetyl pyrimidinium chloride. Mecetronium ethyl sulfate is very particularly preferred.
• the antiperspirant active ingredients can advantageously be present either individually or in a mixture.
• Impregnation solutions according to the invention particularly advantageously comprise the antiperspirant active ingredient (s) according to the invention in concentrations of 4 to 20% by weight, preferably 5 to 15% by weight, in each case based on the total weight of the microemulsion.
• the impregnation solutions according to the invention can advantageously also contain deodorizing active ingredients, for example odor maskers such as the common perfume components, odor absorbers, for example the layered silicates described in patent application DE-P 40 09 347, of which in particular montmorillonite, kaolinite, hit, beidellite, nontronite, saponite, hectorite, Bentonite, smectite, and furthermore, for example, zinc salts of ricinoleic acid.
• odor maskers such as the common perfume components
• odor absorbers for example the layered silicates described in patent application DE-P 40 09 347, of which in particular montmorillonite, kaolinite, hit, beidellite, nontronite, saponite, hectorite, Bentonite, smectite, and furthermore, for example, zinc salts of ricinoleic acid.
• Germ-inhibiting agents are also suitable for being incorporated into the preparations
• advantageous substances are 2,4,4'-trichloro-2'-hydroxydiphenyl ether (irgasane), 1,6-di- (4-chlorophenyl biguanido) hexane (chlorhexidine), 3,4,4'-trichlorocarbanilide, quaternary ammonium compounds, clove oil, mint oil, thyme oil, triethyl citrate, farnesol (3,7,11-trimethyl-2,6, 10-dodecatrien-1-ol) and those described in patent publications DE-37 40 186, DE-39 38 140, DE-42 04 321, DE-42 29 707, DE-42 29 737, DE-42 37 081, DE-43 09 372, DE-43 24 219 described active agents.
• irgasane 1,6-di- (4-chlorophenyl biguanido) hexane
• chlorhexidine 1,6-di- (4-chlorophenyl biguanido) hexan
• the cosmetic or dermatological impregnation solutions according to the invention can be referred to as deodorants or antiperspirants, depending on their active ingredient content; the wipes soaked with these solutions are accordingly deodorant or antiperspirant wipes.
• antioxidants it is advantageous to add conventional antioxidants to the impregnation solutions for the purposes of the present invention. According to the invention, all the antioxidants suitable or customary for cosmetic and / or dermatological applications can be used as favorable antioxidants.
• the antioxidants are advantageously selected from the group consisting of amino acids (eg glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (eg urocanic acid) and their derivatives, peptides such as D, L-carnosine, D-carnosine, L- Camosin and its derivatives (e.g. anserine), carotenoids, carotenes (e.g. ⁇ -carotene, ⁇ -carotene, lycopene) and their derivatives, lipoic acid and their derivatives (e.g. dihydroliponic acid), Aurothio- glucose, propylthiouracil and other thiols (e.g.
• amino acids eg glycine, histidine, tyrosine, tryptophan
• imidazoles eg urocanic acid
• peptides such as D, L-carnosine, D-carnosine, L- Ca
• thioredoxin glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl, Oleyl, ⁇ -linoleyl, cholesteryl and glyceryl esters) and their salts, dialauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and their derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) as well as sulfoximine compounds (e.g.
• buthioninsulfoxim Homocysteine sulfoximine, buthionine sulfones, penta-, hexa-, heptathionine sulfoximine) in very low tolerable doses eg pmol to ⁇ mol / kg
• metal chelators eg ⁇ -hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin
• ⁇ -hydroxy acids eg citric acid, lactic acid, malic acid
• humic acid bile acid, bile extracts, bilirubin, biliverdin, EDTA, EGTA and their derivatives
• unsaturated fatty acids and their derivatives eg ⁇ -linolenic acid, linoleic acid, oleic acid
• folic acid e and their derivatives alanine diacetic acid, flavonoids, polyphenols, catechins, ubiquinone and ubiquinol and
• the amount of the antioxidants (one or more compounds) in the impregnation solutions is preferably 0.001 to 30% by weight, particularly preferably 0.05 to 20% by weight, in particular 0.1 to 10% by weight, based on the total weight the drinking solution.
• vitamin E and / or its derivatives represent the antioxidant or antioxidants, it is advantageous to choose their respective concentrations from the range from 0.001 to 10% by weight, based on the total weight of the impregnation solution.
• the cosmetic and dermatological impregnation solutions according to the invention can contain cosmetic or dermatological auxiliary substances, as are usually used in such preparations, e.g. B. preservatives, preservation aids, bactericides, perfumes, substances to prevent foaming, dyes, Pigments that have a coloring effect, thickeners, moisturizing and / or moisturizing substances, fillers that improve the feeling on the skin, fats, oils, waxes or other common components of a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers, electrolytes, moisturizers , UV filter substances, organic solvents or silicone derivatives.
• cosmetic or dermatological auxiliary substances e.g. B. preservatives, preservation aids, bactericides, perfumes, substances to prevent foaming, dyes, Pigments that have a coloring effect, thickeners, moisturizing and / or moisturizing substances, fillers that improve the feeling on the skin, fats, oils, waxes or other common components of a cosmetic
• Advantageous preservatives for the purposes of the present invention are, for example, formaldehyde releasers (such as, for example, DMDM hydantoin), iodopropyl butyl carbamates (for example those available under the trade names Koncyl-L, Koncyl-S and Konkaben LMB from Lonza), parabens, Phenoxyethanol, ethanol, benzoic acid and the like.
• the preservation system usually also advantageously comprises preservation aids, such as, for example, octoxyglycerol, glycine soya, etc.
• the oil phase impregnation solution in the sense of the present invention is advantageously selected from the group of esters from saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids with a chain length of 3 to 30 carbon atoms and saturated and / or unsaturated, branched and / or unbranched Alcohols with a chain length of 3 to 30 C atoms, from the group of esters from aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols with a chain length of 3 to 30 C atoms.
• ester oils can then advantageously be selected from the group of isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, isononylisononanoate, 2-ethyl-2-ethylhexyl with ethyl Hexyldecyl stearate, cetyl palmitate, 2-octyldodecyl palmitate, oleyl oleate, olerlerucate, erucyl oleate, erucyl erucate as well as synthetic, semisynthetic and natural mixtures of such esters, for example Jojoba oil.
• the oil phase can advantageously be selected from the group of branched and unbranched hydrocarbons and waxes, the silicone oils, the dialkyl ethers, the group of saturated or unsaturated, branched or unbranched alcohols, and also the fatty acid triglycerides, especially the triglycerol esters of saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids with a chain length of 8 to 24, in particular 12 - 18 carbon atoms.
• the fatty acid triglycerides can include can advantageously be chosen from the group of synthetic, semisynthetic and natural oils, for example olive oil, sunflower oil, soybean oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, palm kernel oil and the like.
• any mixtures of such oil and wax components can also be used advantageously for the purposes of the present invention. It may also be advantageous to use waxes, for example cetyl palmitate, as the sole lipid component of the oil phase.
• the oil phase is advantageously selected from the group consisting of 2-ethylhexyl isostearate, octyldodecanol, isotridecyl isononanoate, isoeicosane, 2-ethylhexyl cocoate, C 12 . 15 alkyl benzoate, capyl capric acid triglyceride, dicaprylyl ether.
• C 12 are particularly advantageous. 15- alkylbenzoate and 2-ethylhexyl isostate, mixtures of C 12 . 15 alkylbenzoate and isotridecyl isononanoate and mixtures of C 12 .i 5 alkylbenzoate, 2-ethylhexyl isostearate and isotridecyl isononanoate.
• hydrocarbons paraffin oil, squalane and squalene can be used advantageously for the purposes of the present invention.
• the oil phase can advantageously also have a content of cyclic or linear silicone oils or consist entirely of such oils, although it is preferred to use an additional content of other oil phase components in addition to the silicone oil or the silicone oils.
• Cyclomethicone (octamethylcyclotetrasiloxane) is advantageously used as the silicone oil to be used according to the invention.
• other silicone oils can also be used advantageously for the purposes of the present invention, for example hexamethylcyclotrisiloxane, polydimethylsiloxane, poly (methylphenylsiloxane).
• Preparations according to the present invention can also be distinguished by a content of surfactants.
• Surfactants are amphiphilic substances that can dissolve organic, non-polar substances in water. Due to their specific molecular structure with at least one hydrophilic and one hydrophobic part of the molecule, they ensure a reduction in the surface tension of the water, wetting of the skin, easier removal and removal of dirt, easy rinsing and - if desired - foam regulation.
• Advantageous in the sense of the present invention are:
• Preparations according to the present invention can also advantageously contain further quaternary ammonium compounds, in particular those which are referred to as quaternary surfactants.
• Quaternary surfactants contain at least one N atom which is covalently linked to 4 alkyl or aryl groups.
• Examples 1 to 5 and 8 to 12 are comparative examples which represent the (adhesive) prior art.

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• 2000
  • 2000-12-21 DE DE2000163810 patent/DE10063810A1/de not_active Ceased
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  • 2001-12-18 WO PCT/EP2001/014971 patent/WO2002049591A2/de not_active Application Discontinuation
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