EP1341543A4 - METHODS INVOLVING DEFINED OXIDE PHOSPHOLIPIDS, AND COMPOSITIONS CONTAINING THE SAME, FOR THE PREVENTION AND TREATMENT OF ATHEROSCLEROSIS - Google Patents
METHODS INVOLVING DEFINED OXIDE PHOSPHOLIPIDS, AND COMPOSITIONS CONTAINING THE SAME, FOR THE PREVENTION AND TREATMENT OF ATHEROSCLEROSISInfo
- Publication number
- EP1341543A4 EP1341543A4 EP01997274A EP01997274A EP1341543A4 EP 1341543 A4 EP1341543 A4 EP 1341543A4 EP 01997274 A EP01997274 A EP 01997274A EP 01997274 A EP01997274 A EP 01997274A EP 1341543 A4 EP1341543 A4 EP 1341543A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- atherosclerosis
- prevention
- treatment
- compositions containing
- methods employing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 201000001320 Atherosclerosis Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 150000003904 phospholipids Chemical class 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
- C07F9/106—Adducts, complexes, salts of phosphatides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/11—Aldehydes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
- C07C43/1785—Unsaturated ethers containing hydroxy or O-metal groups having more than one ether bound
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
- C07C43/1787—Unsaturated ethers containing hydroxy or O-metal groups containing six-membered aromatic rings and having unsaturation outside the aromatic rings
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11189562A EP2425841A1 (en) | 2000-11-24 | 2001-11-22 | Methods Employing and Compositions Containing Defined Oxidized Phospholipids for Prevention and Treatment of Atherosclerosis |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25257400P | 2000-11-24 | 2000-11-24 | |
US252574P | 2000-11-24 | ||
PCT/IL2001/001080 WO2002041827A2 (en) | 2000-11-24 | 2001-11-22 | Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1341543A2 EP1341543A2 (en) | 2003-09-10 |
EP1341543A4 true EP1341543A4 (en) | 2009-09-02 |
Family
ID=22956589
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP11189562A Withdrawn EP2425841A1 (en) | 2000-11-24 | 2001-11-22 | Methods Employing and Compositions Containing Defined Oxidized Phospholipids for Prevention and Treatment of Atherosclerosis |
EP01997274A Withdrawn EP1341543A4 (en) | 2000-11-24 | 2001-11-22 | METHODS INVOLVING DEFINED OXIDE PHOSPHOLIPIDS, AND COMPOSITIONS CONTAINING THE SAME, FOR THE PREVENTION AND TREATMENT OF ATHEROSCLEROSIS |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP11189562A Withdrawn EP2425841A1 (en) | 2000-11-24 | 2001-11-22 | Methods Employing and Compositions Containing Defined Oxidized Phospholipids for Prevention and Treatment of Atherosclerosis |
Country Status (9)
Country | Link |
---|---|
EP (2) | EP2425841A1 (es) |
JP (3) | JP4162486B2 (es) |
KR (1) | KR100865142B1 (es) |
CN (1) | CN100577174C (es) |
AU (2) | AU1846102A (es) |
CA (1) | CA2429817C (es) |
IL (1) | IL156015A0 (es) |
MX (1) | MXPA03004517A (es) |
WO (1) | WO2002041827A2 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6838452B2 (en) | 2000-11-24 | 2005-01-04 | Vascular Biogenics Ltd. | Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis |
AU1846102A (en) * | 2000-11-24 | 2002-06-03 | Cardimmune Ltd | Methods employing and compositions containing defined oxidized phospholipids forprevention and treatment of atherosclerosis |
WO2004006910A1 (de) * | 2002-07-15 | 2004-01-22 | Norbert Leitinger | Lipidoxidationsprodukte zur hemmung von entzündungen |
EP2574612A1 (en) * | 2004-07-09 | 2013-04-03 | Vascular Biogenics Ltd. | Improved process for the preparation of oxidized phospholipids |
US7807847B2 (en) * | 2004-07-09 | 2010-10-05 | Vascular Biogenics Ltd. | Process for the preparation of oxidized phospholipids |
AU2007200090B2 (en) * | 2004-07-09 | 2011-09-22 | Vascular Biogenics Ltd. | Improved Process for the Preparation of Oxidized Phospholipids |
US9006217B2 (en) | 2007-01-09 | 2015-04-14 | Vascular Biogenics Ltd. | High-purity phospholipids |
US8569529B2 (en) | 2007-01-09 | 2013-10-29 | Vascular Biogenics Ltd. | High-purity phospholipids |
KR101159406B1 (ko) * | 2008-03-17 | 2012-06-28 | 이화여자대학교 산학협력단 | 혈관 재협착방지 스텐트 코팅용 조성물 및 이를 이용해 제조된 스텐트 |
NZ619895A (en) | 2008-08-12 | 2015-12-24 | Zinfandel Pharmaceuticals Inc | Method of identifying disease risk factors |
US8846315B2 (en) | 2008-08-12 | 2014-09-30 | Zinfandel Pharmaceuticals, Inc. | Disease risk factors and methods of use |
US8999960B2 (en) | 2008-10-08 | 2015-04-07 | Vascular Biogenics Ltd. | Oxidized thiophospholipid compounds and uses thereof |
US9206206B2 (en) * | 2008-11-06 | 2015-12-08 | Vascular Biogenics Ltd. | Oxidized lipid compounds and uses thereof |
BR112012016543A2 (pt) * | 2010-01-05 | 2015-09-01 | Vascular Biogenics Ltd | Tratamento com vb-201 |
AU2012205798B2 (en) | 2011-01-10 | 2016-02-25 | Takeda Pharmaceutical Company Limited | Methods and drug products for treating Alzheimer's disease |
CN103874485B (zh) | 2011-09-01 | 2017-06-09 | 脉管生物生长有限公司 | 氧化的磷脂的制剂和剂型 |
BR112014031086A2 (pt) * | 2012-06-11 | 2017-06-27 | Cleveland Clinic Found | tratamento e prevenção de doenças cardiovasculares e trombose |
US9771385B2 (en) | 2014-11-26 | 2017-09-26 | Vascular Biogenics Ltd. | Oxidized lipids |
EP3223824B1 (en) | 2014-11-26 | 2021-01-06 | Vascular Biogenics Ltd. | Oxidized lipids and treatment or prevention of fibrosis |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
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EP0121088A1 (en) * | 1983-03-05 | 1984-10-10 | A. Nattermann & Cie. GmbH | New o-acyl-alkanediol-phospholipids, processes for their preparation and pharmaceutical preparations containing them |
EP0142333A2 (en) * | 1983-11-08 | 1985-05-22 | Ono Pharmaceutical Co., Ltd. | Glycerol derivatives |
WO1987005904A1 (en) * | 1986-03-24 | 1987-10-08 | The University Of Sydney | Antigenic analogues of platelet activating factor (paf) |
JPS6354386A (ja) * | 1986-08-26 | 1988-03-08 | Takeda Chem Ind Ltd | リン脂質およびその用途 |
JPH01258691A (ja) * | 1988-04-06 | 1989-10-16 | Nippon Oil & Fats Co Ltd | リン脂質誘導体及びその製造方法 |
ES2019552A6 (es) * | 1990-04-11 | 1991-06-16 | Menarini Lab | Procedimiento para la preparacion de glicerofosfolipidos. |
WO1995023592A1 (en) * | 1994-03-04 | 1995-09-08 | The University Of British Columbia | Liposome compositions and methods for the treatment of atherosclerosis |
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NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
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CH642665A5 (en) | 1979-02-08 | 1984-04-30 | Rudolf Berchtold | Process for the preparation of 1-(omega-carboxyalkyl)-2-alkyl- glycero-3-phosphatides |
US4329302A (en) * | 1980-06-27 | 1982-05-11 | Board Of Regents, The University Of Texas System | Synthetic phosphoglycerides possessing platelet activating properties |
US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
US4614796A (en) * | 1983-03-25 | 1986-09-30 | Nippon Shinyaku Co., Ltd. | Liposome and method of manufacture therefor |
JPS60104066A (ja) * | 1983-11-10 | 1985-06-08 | Ono Pharmaceut Co Ltd | グリセリン誘導体 |
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US4827011A (en) * | 1984-12-10 | 1989-05-02 | American Cyanamid Company | Antihypertensive phosphate derivatives |
EP0225129B1 (en) | 1985-11-29 | 1989-05-24 | Takeda Chemical Industries, Ltd. | Phospholipid derivatives, their production and use |
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FR2714382B1 (fr) | 1993-12-27 | 1996-02-02 | Roussel Uclaf | Phospholipides vecteur de molécule active, leur préparation et leur utilisation dans des compositions cosmétiques ou dermatologiques. |
EP0742822B1 (en) | 1994-01-31 | 2004-09-22 | The Institute of Cancer Research: Royal Cancer Hospital | Folding proteins |
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AU1846102A (en) * | 2000-11-24 | 2002-06-03 | Cardimmune Ltd | Methods employing and compositions containing defined oxidized phospholipids forprevention and treatment of atherosclerosis |
-
2001
- 2001-11-22 AU AU1846102A patent/AU1846102A/xx active Pending
- 2001-11-22 CA CA2429817A patent/CA2429817C/en not_active Expired - Fee Related
- 2001-11-22 KR KR1020037006991A patent/KR100865142B1/ko not_active IP Right Cessation
- 2001-11-22 EP EP11189562A patent/EP2425841A1/en not_active Withdrawn
- 2001-11-22 IL IL15601501A patent/IL156015A0/xx active IP Right Grant
- 2001-11-22 MX MXPA03004517A patent/MXPA03004517A/es active IP Right Grant
- 2001-11-22 CN CN01822215A patent/CN100577174C/zh not_active Expired - Lifetime
- 2001-11-22 JP JP2002544008A patent/JP4162486B2/ja not_active Expired - Lifetime
- 2001-11-22 WO PCT/IL2001/001080 patent/WO2002041827A2/en active Application Filing
- 2001-11-22 EP EP01997274A patent/EP1341543A4/en not_active Withdrawn
- 2001-11-22 AU AU2002218461A patent/AU2002218461B2/en not_active Ceased
-
2008
- 2008-06-10 JP JP2008151301A patent/JP5001906B2/ja not_active Expired - Lifetime
-
2012
- 2012-03-16 JP JP2012060309A patent/JP2012149075A/ja active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0121088A1 (en) * | 1983-03-05 | 1984-10-10 | A. Nattermann & Cie. GmbH | New o-acyl-alkanediol-phospholipids, processes for their preparation and pharmaceutical preparations containing them |
EP0142333A2 (en) * | 1983-11-08 | 1985-05-22 | Ono Pharmaceutical Co., Ltd. | Glycerol derivatives |
WO1987005904A1 (en) * | 1986-03-24 | 1987-10-08 | The University Of Sydney | Antigenic analogues of platelet activating factor (paf) |
JPS6354386A (ja) * | 1986-08-26 | 1988-03-08 | Takeda Chem Ind Ltd | リン脂質およびその用途 |
JPH01258691A (ja) * | 1988-04-06 | 1989-10-16 | Nippon Oil & Fats Co Ltd | リン脂質誘導体及びその製造方法 |
ES2019552A6 (es) * | 1990-04-11 | 1991-06-16 | Menarini Lab | Procedimiento para la preparacion de glicerofosfolipidos. |
WO1995023592A1 (en) * | 1994-03-04 | 1995-09-08 | The University Of British Columbia | Liposome compositions and methods for the treatment of atherosclerosis |
Non-Patent Citations (7)
Title |
---|
DEIGNER H P ET AL: "Effect of platelet activating factor on the kinetics of LDL oxidation in vitro", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 317, no. 3, 15 February 1993 (1993-02-15), pages 202 - 206, XP025615837, ISSN: 0014-5793, [retrieved on 19930215] * |
ITABE H ET AL: "Oxidized phosphatidylcholines that modify proteins. Analysis by monoclonal antibody against oxidized low density lipoprotein.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 27 DEC 1996, vol. 271, no. 52, 27 December 1996 (1996-12-27), pages 33208 - 33217, XP002532604, ISSN: 0021-9258 * |
ITABE H ET AL: "Preparation of radioactive aldehyde-containing phosphatidylcholine.", ANALYTICAL BIOCHEMISTRY 1 OCT 2000, vol. 285, no. 1, 1 October 2000 (2000-10-01), pages 151 - 155, XP002532603, ISSN: 0003-2697 * |
KAMIDO H ET AL: "LIPID ESTER-BOUND ALDEHYDES AMONG COPPER-CATALYZED PEROXIDATION PRODUCTS OF HUMA PLASMA LIPOPROTEINS", JOURNAL OF LIPID RESEARCH, BETHESDA, MD, US, vol. 36, 1 January 1995 (1995-01-01), pages 1876 - 1886, XP002951008, ISSN: 0022-2275 * |
KERN H ET AL: "STIMULATION MONOCYTTS AND PLATELETS BY SHORT-CHAIN PHOSPHATIDYLCHOLINES WITH AND WITHOUT TERMINAL CARBOXYL GROUP", BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR CELL RESEARCH, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 1394, no. 1, 1 January 1998 (1998-01-01), pages 33 - 42, XP000938800, ISSN: 0167-4889 * |
LEITINGER N ET AL: "STRUCTURALLY SIMILAR OXIDIZED PHOSPHOLIPIDS DIFFERENTIALLY REGULATE ENDOTHELIAL BINDING OF MONOCYTES AND NEUTROPHILS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC.; US, vol. 96, no. 21, 12 October 1999 (1999-10-12), pages 12010 - 12015, XP002951991, ISSN: 0027-8424 * |
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WO2002041827A3 (en) | 2002-10-10 |
CA2429817A1 (en) | 2002-05-30 |
KR100865142B1 (ko) | 2008-10-24 |
WO2002041827A9 (en) | 2003-05-30 |
AU2002218461B2 (en) | 2006-09-07 |
CN100577174C (zh) | 2010-01-06 |
AU1846102A (en) | 2002-06-03 |
IL156015A0 (en) | 2003-12-23 |
JP2004537498A (ja) | 2004-12-16 |
KR20030077543A (ko) | 2003-10-01 |
JP2012149075A (ja) | 2012-08-09 |
JP2008222726A (ja) | 2008-09-25 |
EP1341543A2 (en) | 2003-09-10 |
WO2002041827A2 (en) | 2002-05-30 |
EP2425841A1 (en) | 2012-03-07 |
JP5001906B2 (ja) | 2012-08-15 |
MXPA03004517A (es) | 2004-03-26 |
CA2429817C (en) | 2013-02-12 |
JP4162486B2 (ja) | 2008-10-08 |
CN1529605A (zh) | 2004-09-15 |
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