EP1341543A4 - Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis - Google Patents

Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis

Info

Publication number
EP1341543A4
EP1341543A4 EP01997274A EP01997274A EP1341543A4 EP 1341543 A4 EP1341543 A4 EP 1341543A4 EP 01997274 A EP01997274 A EP 01997274A EP 01997274 A EP01997274 A EP 01997274A EP 1341543 A4 EP1341543 A4 EP 1341543A4
Authority
EP
European Patent Office
Prior art keywords
atherosclerosis
prevention
treatment
compositions containing
methods employing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01997274A
Other languages
German (de)
French (fr)
Other versions
EP1341543A2 (en
Inventor
Dror Harats
Jacob George
Gideon Halperin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Notable Labs Ltd
Original Assignee
Vascular Biogenics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22956589&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP1341543(A4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vascular Biogenics Ltd filed Critical Vascular Biogenics Ltd
Priority to EP11189562A priority Critical patent/EP2425841A1/en
Publication of EP1341543A2 publication Critical patent/EP1341543A2/en
Publication of EP1341543A4 publication Critical patent/EP1341543A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C07F9/106—Adducts, complexes, salts of phosphatides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
    • C07C43/1785—Unsaturated ethers containing hydroxy or O-metal groups having more than one ether bound
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
    • C07C43/1787—Unsaturated ethers containing hydroxy or O-metal groups containing six-membered aromatic rings and having unsaturation outside the aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP01997274A 2000-11-24 2001-11-22 Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis Withdrawn EP1341543A4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP11189562A EP2425841A1 (en) 2000-11-24 2001-11-22 Methods Employing and Compositions Containing Defined Oxidized Phospholipids for Prevention and Treatment of Atherosclerosis

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25257400P 2000-11-24 2000-11-24
US252574P 2000-11-24
PCT/IL2001/001080 WO2002041827A2 (en) 2000-11-24 2001-11-22 Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis

Publications (2)

Publication Number Publication Date
EP1341543A2 EP1341543A2 (en) 2003-09-10
EP1341543A4 true EP1341543A4 (en) 2009-09-02

Family

ID=22956589

Family Applications (2)

Application Number Title Priority Date Filing Date
EP01997274A Withdrawn EP1341543A4 (en) 2000-11-24 2001-11-22 Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
EP11189562A Withdrawn EP2425841A1 (en) 2000-11-24 2001-11-22 Methods Employing and Compositions Containing Defined Oxidized Phospholipids for Prevention and Treatment of Atherosclerosis

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP11189562A Withdrawn EP2425841A1 (en) 2000-11-24 2001-11-22 Methods Employing and Compositions Containing Defined Oxidized Phospholipids for Prevention and Treatment of Atherosclerosis

Country Status (9)

Country Link
EP (2) EP1341543A4 (en)
JP (3) JP4162486B2 (en)
KR (1) KR100865142B1 (en)
CN (1) CN100577174C (en)
AU (2) AU1846102A (en)
CA (1) CA2429817C (en)
IL (1) IL156015A0 (en)
MX (1) MXPA03004517A (en)
WO (1) WO2002041827A2 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100865142B1 (en) * 2000-11-24 2008-10-24 바스큘라 바이오제닉스 리미티드 Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
US6838452B2 (en) * 2000-11-24 2005-01-04 Vascular Biogenics Ltd. Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
AU2003243806A1 (en) * 2002-07-15 2004-02-02 Bernd Binder Lipid oxidation products for inhibiting inflammation
KR101201935B1 (en) * 2004-07-09 2012-11-16 바스큘라 바이오제닉스 리미티드 Improved process for the preparation of oxidized phospholipids
US7807847B2 (en) 2004-07-09 2010-10-05 Vascular Biogenics Ltd. Process for the preparation of oxidized phospholipids
AU2007200090B2 (en) * 2004-07-09 2011-09-22 Vascular Biogenics Ltd. Improved Process for the Preparation of Oxidized Phospholipids
US8569529B2 (en) 2007-01-09 2013-10-29 Vascular Biogenics Ltd. High-purity phospholipids
US9006217B2 (en) 2007-01-09 2015-04-14 Vascular Biogenics Ltd. High-purity phospholipids
WO2009116750A2 (en) * 2008-03-17 2009-09-24 이화여자대학교 산학협력단 Composition for the coating of stent for preventing restenosis and stent manufactured using same
JP5833922B2 (en) 2008-08-12 2015-12-16 ジンファンデル ファーマシューティカルズ インコーポレイテッド Methods for identifying disease risk factors
US8846315B2 (en) 2008-08-12 2014-09-30 Zinfandel Pharmaceuticals, Inc. Disease risk factors and methods of use
US8999960B2 (en) 2008-10-08 2015-04-07 Vascular Biogenics Ltd. Oxidized thiophospholipid compounds and uses thereof
EP2348866B1 (en) * 2008-11-06 2015-01-07 Vascular Biogenics Ltd. Oxidized lipid compounds and uses thereof
WO2011083469A1 (en) * 2010-01-05 2011-07-14 Vascular Biogenics Ltd. Treatment with vb-201
EP2665479B1 (en) 2011-01-10 2019-06-26 Zinfandel Pharmaceuticals, Inc. Methods and drug products for treating alzheimer's disease
AU2012301602B2 (en) 2011-09-01 2015-09-03 Vascular Biogenics Ltd. Formulations and dosage forms of oxidized phospholipids
MX2014015197A (en) * 2012-06-11 2015-11-16 Cleveland Clinic Foundation Treatment and prevention of cardiovascular disease and thrombosis.
US9771385B2 (en) 2014-11-26 2017-09-26 Vascular Biogenics Ltd. Oxidized lipids
CA2968790A1 (en) 2014-11-26 2016-06-02 Vascular Biogenics Ltd. Oxidized lipids and treatment or prevention of fibrosis

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ES2019552A6 (en) * 1990-04-11 1991-06-16 Menarini Lab Process for the preparation of glycerophospholipids
WO1995023592A1 (en) * 1994-03-04 1995-09-08 The University Of British Columbia Liposome compositions and methods for the treatment of atherosclerosis

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0121088A1 (en) * 1983-03-05 1984-10-10 A. Nattermann & Cie. GmbH New o-acyl-alkanediol-phospholipids, processes for their preparation and pharmaceutical preparations containing them
EP0142333A2 (en) * 1983-11-08 1985-05-22 Ono Pharmaceutical Co., Ltd. Glycerol derivatives
WO1987005904A1 (en) * 1986-03-24 1987-10-08 The University Of Sydney Antigenic analogues of platelet activating factor (paf)
JPS6354386A (en) * 1986-08-26 1988-03-08 Takeda Chem Ind Ltd Phospholipid and use thereof
JPH01258691A (en) * 1988-04-06 1989-10-16 Nippon Oil & Fats Co Ltd Phospholipid derivative and production thereof
ES2019552A6 (en) * 1990-04-11 1991-06-16 Menarini Lab Process for the preparation of glycerophospholipids
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KAMIDO H ET AL: "LIPID ESTER-BOUND ALDEHYDES AMONG COPPER-CATALYZED PEROXIDATION PRODUCTS OF HUMA PLASMA LIPOPROTEINS", JOURNAL OF LIPID RESEARCH, BETHESDA, MD, US, vol. 36, 1 January 1995 (1995-01-01), pages 1876 - 1886, XP002951008, ISSN: 0022-2275 *
KERN H ET AL: "STIMULATION MONOCYTTS AND PLATELETS BY SHORT-CHAIN PHOSPHATIDYLCHOLINES WITH AND WITHOUT TERMINAL CARBOXYL GROUP", BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR CELL RESEARCH, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 1394, no. 1, 1 January 1998 (1998-01-01), pages 33 - 42, XP000938800, ISSN: 0167-4889 *
LEITINGER N ET AL: "STRUCTURALLY SIMILAR OXIDIZED PHOSPHOLIPIDS DIFFERENTIALLY REGULATE ENDOTHELIAL BINDING OF MONOCYTES AND NEUTROPHILS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC.; US, vol. 96, no. 21, 12 October 1999 (1999-10-12), pages 12010 - 12015, XP002951991, ISSN: 0027-8424 *
SUBBANAGOUNDER G ET AL: "DETERMINANTS OF BIOACTIVITY OF OXIDIZED PHOSPHOLIPIDS SPECIFIC OXIDIZED FATTY ACYL GROUPS AT THE SN-2 POSITION", ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, no. 20, 1 January 2000 (2000-01-01), pages 2248 - 2254, XP002951986, ISSN: 1079-5642 *

Also Published As

Publication number Publication date
EP2425841A1 (en) 2012-03-07
WO2002041827A3 (en) 2002-10-10
KR20030077543A (en) 2003-10-01
JP2004537498A (en) 2004-12-16
WO2002041827A9 (en) 2003-05-30
WO2002041827A2 (en) 2002-05-30
JP2008222726A (en) 2008-09-25
JP2012149075A (en) 2012-08-09
EP1341543A2 (en) 2003-09-10
IL156015A0 (en) 2003-12-23
AU1846102A (en) 2002-06-03
CA2429817C (en) 2013-02-12
AU2002218461B2 (en) 2006-09-07
MXPA03004517A (en) 2004-03-26
JP5001906B2 (en) 2012-08-15
CA2429817A1 (en) 2002-05-30
KR100865142B1 (en) 2008-10-24
CN100577174C (en) 2010-01-06
CN1529605A (en) 2004-09-15
JP4162486B2 (en) 2008-10-08

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