EP1339311A4 - Procede et appareil pour effectuer un traitement tissulaire - Google Patents

Procede et appareil pour effectuer un traitement tissulaire

Info

Publication number
EP1339311A4
EP1339311A4 EP01975258A EP01975258A EP1339311A4 EP 1339311 A4 EP1339311 A4 EP 1339311A4 EP 01975258 A EP01975258 A EP 01975258A EP 01975258 A EP01975258 A EP 01975258A EP 1339311 A4 EP1339311 A4 EP 1339311A4
Authority
EP
European Patent Office
Prior art keywords
ultrasound
body region
visualization
providing
transducer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01975258A
Other languages
German (de)
English (en)
Other versions
EP1339311A2 (fr
Inventor
Narendra T Sanghvi
Arieh L Shalhav
Mihir K Biswas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Focus Surgery Inc
Original Assignee
Focus Surgery Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Focus Surgery Inc filed Critical Focus Surgery Inc
Publication of EP1339311A2 publication Critical patent/EP1339311A2/fr
Publication of EP1339311A4 publication Critical patent/EP1339311A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3417—Details of tips or shafts, e.g. grooves, expandable, bendable; Multiple coaxial sliding cannulas, e.g. for dilating
    • A61B17/3421—Cannulas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3474—Insufflating needles, e.g. Veress needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/378—Surgical systems with images on a monitor during operation using ultrasound

Definitions

  • This invention relates to instruments for the conduct of minimally invasive medical procedures which may be conducted with the aid of laparoscopic techniques, and to such procedures themselves. It is disclosed in the context of high- intensity focused ultrasound ablation of kidney tissue, but is believed to be useful in other applications as well.
  • HIFU high-intensity focused ultrasound
  • the disclosures of these references are hereby incorporated herein by reference. This listing is not intended to be a representation that a thorough search has been made of the
  • an apparatus and method employ first, second and third devices for introduction of equipment into, and removal of equipment from, a body region, an optical imaging system, a source of a relatively non-reactive fluid for expanding the body region to facilitate the introduction of components of the apparatus into the body region and mampulation of the introduced components of apparatus, and an ultrasound apparatus for at least one of visualization and treatment of the body region.
  • a first of the devices facilitates passing of the component of the optical imaging system into and out of the body region.
  • a second of the devices facilitates passing the fluid between the fluid source and the body region.
  • a third of the devices facilitates passing the ultrasound visualization and/or treatment apparatus into and out of the body region.
  • the optical imaging system includes at least one of: a light source; a first optical fiber having a first end adjacent the light source and a second end remote from the light source for coupling light from the light source to the second end of the optical fiber; a second optical fiber for coupling light from a first end of the second optical fiber to a second end of the second optical fiber; and, an optical imaging device coupled to the second end of the second optical fiber.
  • the first device permits sealing introduction of a component of the optical imaging system into, and removal of the component of the optical imaging system from the body region to reduce the likelihood of the escape of the fluid from the body region.
  • the first device includes a first device for passing the second end of the first optical fiber and the first end of the second optical fiber into and from the body region.
  • the first device includes a first device for sealingly introducing the optical fiber into, and removing the optical fiber from, the body region to reduce the likelihood of the escape of the fluid from the body region.
  • the optical imaging device includes a video camera. Additionally illustratively according to this aspect of the invention, the optical imaging device includes a surgical monitor.
  • the source of relatively non-reactive fluid includes a source of a relatively non-reactive gas or non- reactive mixture of gases.
  • the second device includes a second device for sealingly introducing relatively non- reactive gas or non-reactive mixture of gases into, and removing relatively non- reactive gas or non-reactive mixture of gases from the body region to reduce the likelihood of the escape of the relatively non-reactive gas or non-reactive mixture of gases from the body region.
  • the ultrasound apparatus includes an ultrasound transducer for high-intensity focused ultrasound (HIFU) treatment of the body region.
  • HIFU high-intensity focused ultrasound
  • the third device includes a third device for sealingly introducing the HIFU treatment transducer into, and removing the HTFU treatment transducer from, the body region to reduce the likelihood of the escape of the relatively non-reactive fluid from the body region.
  • the ultrasound apparatus includes an ultrasound transducer for visualization of the body region.
  • the third device includes a third device for sealingly introducing the visualization transducer into, and removing the visualization transducer from, the body region to reduce the likelihood of the escape of the relatively non-reactive fluid from the body region.
  • the ultrasound visualization and/or treatment apparatus further includes a device for displaying an ultrasound image generated from information received by the transducer.
  • the ultrasound image display device is coupled to the visualization transducer by conductors which extend through the third device.
  • the HTFU treatment and ultrasound visualization transducers are combined into a multielement ultrasound transducer.
  • the ultrasound apparatus for at least one of visuahzation and treatment of the body region includes multiple ultrasound transducers capable of being driven to provide HIFU treatment of the body region.
  • At least one of the multiple ultrasound transducers capable of being driven to provide HIFU treatment of the body region is also capable of being driven to provide visualization of the body region.
  • each of the multiple ultrasound transducers is capable of being driven to provide visualization of the body region.
  • the invention further includes introducing species containing at least one of: microcapsule-seeded species; microbubble-seeded species; and, relatively non-reactive gas or relatively non-reactive mixture of gases, and exposing the at least one of: microcapsule-seeded species; microbubble-seeded species; and, relatively non-reactive gas or relatively non-reactive mixture of gases to ultrasound to cause an echogenic field to appear on the ultrasound display device.
  • the invention further includes introducing species containing at least one of: microcapsule-seeded species; microbubble-seeded species; and, relatively non-reactive gas or non-reactive mixture of gases, and exposing the at least one of: microcapsule-seeded species; microbubble-seeded species; and, relatively non-reactive gas or non-reactive mixture of gases to ultrasound to cause cavitation of the at least one of: microcapsule-seeded species; microbubble-seeded species; and, relatively non-reactive gas or relatively non-reactive mixture of gases.
  • providing an ultrasound apparatus for at least one of visualization and treatment of the body region includes providing a coupling medium between the first ultrasound transducer and tissue to be treated in the body region.
  • providing a coupling medium between the first ultrasound transducer and tissue to be treated in the body region includes providing around the first ultrasound transducer a flexible reservoir, providing the coupling medium in the reservoir, and placing the reservoir into contact with tissue to be treated in the body region.
  • the flexible reservoir is constrained to deflect in certain ways when a sufficient volume of the coupling medium is introduced into the flexible reservoir to cause it to deflect.
  • an apparatus and method employ first and second devices for introduction of equipment into, and removal of equipment from, a body region, a source of a relatively non-reactive fluid for expanding the body region to facilitate the introduction of components of the apparatus into the body region and manipulation of the introduced components of apparatus and an ultrasound apparatus for at least one of visualization and treatment of the body region.
  • the fluid passes between the fluid source and the body region through the first device.
  • the ultrasound visualization and/or treatment apparatus passes through the second device.
  • the source of a relatively non-reactive fluid for expanding the body region includes a source of a relatively non-reactive gas or non-reactive mixture of gases.
  • the first device includes a first device for sealingly introducing relatively non-reactive fluid into, and removing relatively non-reactive fluid from, the body region.
  • the ultrasound apparatus includes a first ultrasound transducer for high-intensity focused ultrasound (HIFU) treatment of the body region.
  • HIFU high-intensity focused ultrasound
  • the second device includes a second device for sealingly introducing the HIFU treatment transducer into, and removing the HIFU treatment transducer from, the body region.
  • the ultrasound apparatus includes a second ultrasound transducer for visualization of the body region.
  • the second device includes a second device for sealingly introducing the visualization transducer into, and removing the visualization transducer from, the body region.
  • the ultrasound visualization and/or treatment apparatus further includes a device for displaying an ultrasound image generated from information received by the ultrasound visualization transducer, and conductors for coupling the ultrasound visualization transducer through the second device to the ultrasound display device.
  • the first and second transducers are combined in a multi-element ultrasound transducer.
  • the second device includes a second device for sealingly introducing the multi-element ultrasound transducer into, and removing the multi-element ultrasound transducer from, the body region.
  • the ultrasound apparatus for at least one of visualization and treatment of the body region includes multiple ultrasound transducers for providing HIFU treatment of the body region.
  • At least one of the multiple ultrasound transducers for providing HIFU treatment of the body region is also capable of being driven to provide visualization of the body region. Further illustratively according to this aspect of the invention, each of the multiple ultrasound transducers is capable of being driven to provide visualization of the body region.
  • FIG. 1 illustrates a partly block diagrammatic, partly fragmentary perspective view of a procedure according to the present invention
  • Fig. 2 illustrates an exploded, fragmentary perspective view of a device useful in the conduct of the procedure illustrated in Fig. 1;
  • Fig. 3 illustrates a perspective view of another device constructed according to the invention
  • Fig. 4 illustrates a perspective view of another device constructed according to the invention
  • Fig. 5 illustrates a perspective view of certain components of another device constructed according to the invention
  • Fig. 6 illustrates a plan view of the components illustrated in Fig. 5
  • Fig. 7 illustrates an elevational view of the components illustrated in Figs. 5-6; and,
  • Fig. 8 illustrates an end elevational view of the components illustrated in Figs. 5-7.
  • the patient 20 is first prepared by the insertion of a guide wire 24 through the urethra 28 and bladder 32 into the ureter 36 of a diseased kidney 40.
  • the guide wire 24 is, of course, radiopaque, so that its progress to the surgical field can be straightforwardly monitored.
  • a urological catheter 44 is inserted along the same path to permit the introduction of fluid species into the surgical site 48.
  • three incisions 50, 52, 54 are made on the abdomen 56 below the diaphragm through trocars 60.
  • the trocars 60 are left in place, as is customary, to permit the sealing of the abdomen 56 when instruments are passed through the seals 64 of the trocars 60 into the abdomen 56 for the conduct of the procedure.
  • a laparoscope 68 for providing visual observation of the surgical field is passed through one of the trocars 60.
  • the laparoscope 68 is conventionally coupled to a video camera 72 and a light source 76 for illuminating the surgical field and returning images to a surgical monitor 84.
  • the laparoscope provides a pair of fiberoptic ports, one an output port for light from source 76 to the surgical field, and one an input port for the returning image information to video camera 72.
  • a second of the trocars 60 provides, among other things, a passageway for the introduction into the abdomen 56 of a relatively inert gas, such as, for example, carbon dioxide, from a source 88 in order to permit the inflation of the abdomen 56 below the diaphragm. This increases the space inside the abdomen 56 for maneuvering surgical instruments including the laparoscope 68, and provides a clearer view of the surgical field.
  • a relatively inert gas such as, for example, carbon dioxide
  • the third trocar 60 provides access through the abdominal wall and into the surgical field for a HIFU probe 90 which will be used to ablate the surgical site 48 of a diseased kidney 40, for example, for the virtually bloodless ablation of (a) tumor(s) on the surface of, and/or within, the kidney 40.
  • additional trocars 60 can, of course, be provided for passing into the body additional HTFU probes 90 to be used in conjunction with each other in an ablation procedure.
  • the presence of the catheter 44 in the kidney 40 also permits the introduction into the surgical field of (an) ablation enhancing medium (media) and other media at (an) appropriate time(s) during the procedure.
  • the same, or a different, medium (media) may also be introduced through the catheter 44 to improve the accuracy of the targeting of the surgical site 48 for ablation and provide feedback to the treating physician of the progress of the treatment.
  • medium media
  • lesions which are not on the surface of the tissue 40 being treated are not easily visible, or in many cases visible at all, in the laparoscopically informed monitor 84.
  • the ultrasound probe 90 includes an ultrasound visualization capability.
  • additional mechanism(s) may be provided for essentially real-time monitoring of the progress of the treatment.
  • relatively inert gas-containing microcapsule- or microbubble-seeded species such as sterile saline solution
  • a relatively inert gas again, such as carbon dioxide, and so on. Any suitable one or ones of these mechanisms can be used to introduce any of such media via the catheter 44 into the kidney 40 being treated.
  • Such materials are known to create bright echogenic bands, strips, fields, and the like on, for example, B-mode ultrasound imaging scans 86. Such phenomena can be used to indicate to the treating physician where the HIFU has been effective.
  • the treating physician continues to expose the tissue 40 under treatment to the HIFU until the material produces a "bloom" or bright echogenic field, band, strip or the like in the ultrasound image 86 of the treatment field.
  • the HTFU probe 90 is repositioned to treat the next region which is to be treated according to the treatment regimen.
  • Some of such species may also function to enhance the ablation effects of the applied HIFU.
  • some of such species readily produce cavitation, the bursting of bubbles created when the species are exposed to HTFU above certain field strengths and/or for certain lengths of time.
  • the cavitation is known to cause further mechanical alteration of the character of the tissue at the surgical site 48 at a cellular level, enhancing the effects of the HIFU exposure. This ultimately results in reduced treatment times.
  • This treatment is not limited to kidneys. It is presently believed to be applicable equally readily to the ablation of tissue on the surface of, or in the bulk of, for example, the liver, the pancreas, the urinary bladder 32, the gall bladder, the stomach, the heart, lungs, and so on.
  • the probe 90 could be integrated into, or mounted to be manipulated by, a robotic mechanism 92, and controlled, for example, by means of a joystick 94, keypad 96, programmable machine 100, or any other appropriate control mechanism. Any of such mechanisms 92, 94, 96, 100 can incorporate feedback control (illustrated by broken lines), not only of a visual nature, provided via a laparoscope 68, but also of the ultrasound imaging type via probe 90.
  • the ultrasound image 86 feedback may be not only of the more conventional type described above, but also, may be of a somewhat more highly processed nature, such as that described in, for example, U. S. S. N. 60/200,695, filed April 29, 2000, titled Non-Invasive Tissue Characterization, assigned to the assignee of this application, and hereby incorporated herein by reference. It is contemplated that the feedback could provide the treating physician with highly detailed information on the progress of treatment, such as, for example, when the tissue being treated reaches a particular temperature, when the character of the tissue at a cellular level changes abruptly, and so on.
  • the illustrated probe 90 itself is, for example, a modified Sonablate 200 probe available from Focus Surgery, Inc., 3940 Pendleton Way, Indianapolis, Indiana, 46226.
  • the Sonablate 200 system is hereby incorporated herein by reference.
  • the probe 90 includes a segmented, curved rectangular elliptical transducer 104 of the general type described in, for example, WO 99/49788.
  • the transducer 104 has a central segment 108 which is used both for visualization and therapy and (an) outer segment(s) 112 which is (are) used for therapy, in accordance with known principles.
  • other single element or multi-segment transducer configurations such as ones providing variable focal length, can be used to advantage in other embodiments of the invention. Some of such variable focal length configurations, and driving and receiving systems for them, are described in the prior art incorporated herein by reference.
  • the illustrated transducer 104 has a length of about 3 cm., a width of about 1.3 cm., and a focal length of about 3.5 cm. This is adequate to treat tumors of the kidney 40 to that depth.
  • the HTFU treatment of deeper seated tissue will, of course, require longer focal length treatment transducers.
  • the transducer 104 is mounted in a holder 116 having the same generally rectangular prism-shaped outline as the outer dimensions of the transducer 104 itself.
  • the holder 116 is mounted on the end of a hollow shaft 120 through which the electrical leads to drive the transducer 104 for imaging 86 and therapy can be passed between the transducer 104 and the driver and imaging circuitry, for example, the driver and imaging circuitry of the above-mentioned Sonablate 200 system, in a controller 124 (Fig. 1).
  • the shaft 120 itself can serve as one of the conductors, for example, the ground conductor, for one or more of the ultrasound-generating segment(s) 108, 112 of the transducer 104.
  • the transducer 104/holder 116/shaft 120 assembly is housed in a housing 128 which illustratively is about 50 cm in length and has an outside diameter which is sufficiently small to fit through one of the standard trocar 60 seals 64, for example, an 18 mm seal 64, sufficiently tightly to seal the inside of the abdominal cavity in use.
  • a housing 128 which illustratively is about 50 cm in length and has an outside diameter which is sufficiently small to fit through one of the standard trocar 60 seals 64, for example, an 18 mm seal 64, sufficiently tightly to seal the inside of the abdominal cavity in use.
  • the dimensions of the illustrated transducer 104, holder 116 and housing 128 given above are for a probe 90 for the treatment of certain kidney 40 tissue.
  • the size, shape and focal length of the probe 90 and transducer 104 will depend to a great extent on the requirements of the tissue or organ which the probe 90 is intended to treat. For example, a liver probe may be required to be somewhat larger and have a longer focal length, and so on.
  • the abdominal cavity will be pressurized with gas during the procedure to increase the work space inside the abdominal cavity.
  • a gas will ordinarily be used during the procedure to inflate the abdomen 56, provision must be made for coupling the ultrasound transducer 104 to the tissue being treated. This may be done by providing a cot or condom 132 over the window 136 through the housing 128 through which the ultrasound radiating face 140 of the transducer 104 transmits ultrasound, and filling the housing 128 with an appropriate coupling medium, for example, degassed water and permitting air to escape from the housing 128 as it is being filled.
  • One or more ports may be provided in the housingl28 for filling it with coupling medium and bleeding air from it.
  • the cot 132 may be sealed to the housingl28 longitudinally of the housingl28 on either side of the window 136 by elastomeric O-ring seals 144. This reduces the amount of coupling fluid necessary inside the housing 128 to cause the cot 132 to bulge out sufficiently to bring it into intimate contact with the surface of the tissue 40 to be treated.
  • the sleeve 148 illustratively is constructed of a thin, sterilizable or sterile disposable material, such as, for example, a resin or light metal.
  • the sleeve 148 slides or snaps around the housing 128 in the region of the ultrasound window 136 after the cot 132 has been placed over the window 136, and either before or after the O-rings 144 have been positioned adjacent the longitudinal ends of the window 136.
  • the sleevel48 is intended to reduce the bulging of the cot 132 anywhere other than in the immediate vicinity of the window 136. This reduces the amount of coupling fluid necessary to cause the cot 132 to bulge into intimate contact with the tissue 40 by reducing the volume of coupling fluid necessary to cause adequate bulging of the cot 132.
  • ulfrasound tissue imaging 86 is deep tissue imaging, not surface imaging.
  • Surface imaging in the illustrated application is provided by the laparoscope 68 's vision system 76, 72, 84. It is helpful for both gross and fine positioning of the probe 90, including tissue contact with the cot 132 filled with coupling medium, and for momtoring the progress of treatment. For example, visualization permits the physician to determine when the tissue 40 being treated exhibits surface blanching 156 (Fig. 1). The presence of blanching 156 provides visual feedback to the treating physician that the tissue 40 being treated has received an amount of heat, at least on its surface, to achieve a particular level of ablation.
  • this surface imaging could also be provided by means of a light source and video return on the probe 90 itself.
  • the light source and video return on the probe 90 itself might take the form of an LED or other light source provided on the probe 90 adjacent the window 136, and a miniature video image generator of some type also adjacent the window 136, or some other combination of image-generating components.
  • the probe 180 takes the form of one jaw of a forceps-like clamp 184.
  • the other jaw 188 of the clamp 184 serves with the clamping jaw/probe 180 to capture the tissue 192 to be treated between the two jaws 180, 188.
  • both jaws 280, 288 can take the form of probes so that the tissue 292 to be treated could be treated by both probes 280, 288 or by whichever one of the probes 280, 288 is optimally positioned to treat the tissue 292 to be treated.
  • the ultrasound transducers 104, 104 in the two probe/jaws 280, 288 could have different characteristics, for example, different power handling capabilities or focal lengths, in order to provide a greater number of treatment options to the physician when the probes/jaws 280, 288 are in position to treat the tissue 292.
  • a probe 90' includes a holder 116' for mounting part-spherical visualization and treatment transducers 302, 304 having radii of, for example, 30 mm for transducer 302 and 15 mm for transducer 304. Both of transducers 302, 304 are capable of operation in visualization and HTFU treatment modes. And, of course, either or both of transducers 302, 304 can be a multi-element transducer of any of the known types including transducer 104 illustrated in Figs. 1-2. In this embodiment, the end cap and the end O-ring seal 144 of the embodiment illustrated in Figs.
  • Holder 116' also includes its own fiberoptic passageway 306 having a diameter of, for example, .5 mm. Passageway 306 extends out to the surface of transducer 304 to provide optical visualization of tissue being treated, which tissue may also be visualized by ultrasound and or treated by transducer 304.
  • the optical fiber(s) which extend(s) through passageway 306 is (are) coupled to an illumination optical visualization system of known type, such as the system 72, 76, 84 illustrated and briefly described in connection with the embodiment illustrated in Figs. 1-2.

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)
  • Endoscopes (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Laser Surgery Devices (AREA)

Abstract

L'invention concerne un appareil et un procédé faisant appel à un premier, un deuxième et un troisième trocart (60) servant à introduire un équipement dans une région du corps, et à retirer ledit équipement de cette dernière. Cet appareil et ce procédé font également appel à un système d'imagerie optique (fibres optiques, 72, 76, 84), à une source (88) de fluide relativement inerte, servant à créer une expansion au niveau de la région du corps dans le but de faciliter l'introduction des éléments de l'appareil dans cette dernière, et à un appareil à ultrasons (108, 112, 302, 304) servant à visualiser et/ou traiter ladite région du corps. Un premier trocart (60) facilite l'introduction de l'élément (fibres optiques) du système d'imagerie optique (fibres optiques, 72, 76, 84) dans la région du corps et son retrait de cette dernière. Un deuxième trocart (60) facilite le passage du fluide entre la source de fluide (88) et la région du corps. Un troisième trocart (60) facilite l'introduction de l'appareil de visualisation et/ou de traitement à ultrasons (108, 112, 302, 304) dans la région du corps et son retrait de cette dernière.
EP01975258A 2000-09-19 2001-09-19 Procede et appareil pour effectuer un traitement tissulaire Withdrawn EP1339311A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23379500P 2000-09-19 2000-09-19
US233795P 2000-09-19
PCT/US2001/029359 WO2002024050A2 (fr) 2000-09-19 2001-09-19 Procede et appareil pour effectuer un traitement tissulaire

Publications (2)

Publication Number Publication Date
EP1339311A2 EP1339311A2 (fr) 2003-09-03
EP1339311A4 true EP1339311A4 (fr) 2008-04-30

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Application Number Title Priority Date Filing Date
EP01975258A Withdrawn EP1339311A4 (fr) 2000-09-19 2001-09-19 Procede et appareil pour effectuer un traitement tissulaire

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Country Link
EP (1) EP1339311A4 (fr)
JP (1) JP2004508867A (fr)
AU (1) AU2001294598A1 (fr)
WO (1) WO2002024050A2 (fr)

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EP1339311A2 (fr) 2003-09-03
AU2001294598A1 (en) 2002-04-02
JP2004508867A (ja) 2004-03-25
WO2002024050A3 (fr) 2003-06-26

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