EP1332004A1 - Atomiseur destine a des liquides - Google Patents

Atomiseur destine a des liquides

Info

Publication number
EP1332004A1
EP1332004A1 EP01988629A EP01988629A EP1332004A1 EP 1332004 A1 EP1332004 A1 EP 1332004A1 EP 01988629 A EP01988629 A EP 01988629A EP 01988629 A EP01988629 A EP 01988629A EP 1332004 A1 EP1332004 A1 EP 1332004A1
Authority
EP
European Patent Office
Prior art keywords
storage container
atomizer according
liquid
pump
neck
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01988629A
Other languages
German (de)
English (en)
Inventor
Patrick Hettrich
Peter Asp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Publication of EP1332004A1 publication Critical patent/EP1332004A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0037—Containers
    • B05B11/0039—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means
    • B05B11/0044—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0037—Containers
    • B05B11/0039—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means
    • B05B11/0044—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means
    • B05B11/00444—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means with provision for filtering or cleaning the air flow drawn into the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0037—Containers
    • B05B11/0039—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means
    • B05B11/0044—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means
    • B05B11/00446—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means the means being located at the bottom of the container or of an enclosure surrounding the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1001—Piston pumps
    • B05B11/1021—Piston pumps having an outlet valve which is a gate valve
    • B05B11/1022—Piston pumps having an outlet valve which is a gate valve actuated by pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/08—Inhaling devices inserted into the nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/75—General characteristics of the apparatus with filters
    • A61M2205/7518—General characteristics of the apparatus with filters bacterial
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/75—General characteristics of the apparatus with filters
    • A61M2205/7536—General characteristics of the apparatus with filters allowing gas passage, but preventing liquid passage, e.g. liquophobic, hydrophobic, water-repellent membranes

Definitions

  • the present invention relates to a new atomizer for atomizing a pharmaceutical liquid for application of a medical-pharmaceutical aerosol, the active substance formulation always being kept under sterile conditions.
  • the aerosols generated in this way can be applied, for example, nasally, orally, via the ears or on the skin. Nasal application is preferred.
  • Moisturizers, medicines and / or wound healing agents can be applied via the atomizer.
  • nasal sprays of the type described above i.e. nasal sprays for constant and repeated use
  • the atomizers on the one hand have a relatively large reservoir of active ingredients, but on the other hand they do not become too heavy so that the spray does not consume too quickly and the user can always carry the nasal spray with him at the same time.
  • the storage containers consist of plastic bottles. However, they have the disadvantage that they are not tasteless and not diffusion-tight with regard to gas. As a result, oxygen can easily diffuse into the storage container and lead to the oxidation of active ingredient components.
  • the object of the present invention is therefore to provide an atomizer which overcomes the difficulties known from the prior art.
  • an atomizer which consists of an aluminum storage container and a pump attachment, which allows manual atomization by means of a pump movement and sterilizes inflowing air to equalize the pressure in the storage container.
  • the active ingredient formulation is always under normal pressure, overpressure can be dispensed with.
  • the pump attachment must have the following features: - a snap or crimp closure for placement on the storage container;
  • a pump channel that can pump liquid from the reservoir into a pressure chamber
  • a pressure control valve which is connected to the riser pipe, which is preferably formed in the riser pipe;
  • a release element via which a piston can be actuated, which builds up the pressure required for nebulization in the pressure chamber;
  • Means for sterilization along the path the incoming air takes i.e. between the air inlet openings and the storage container.
  • the pump attachment is preferably one as described, for example, in WO 97/18902 and shown in FIG. 1.
  • the pump attachment (2) is firmly connected to the bottle neck (102) via the snap closure (3).
  • the inner edge of the snap closure (4) slides over the flange-shaped edge (105) of the bottle neck (102).
  • Liquid can be pumped from the reservoir into the pressure chamber (10) via a first pump channel (25).
  • the pressure chamber (10) can be formed as part of the first pump channel (25) in its upper region.
  • a ball valve (11) closes the path of the liquid through the first pump channel (25) into the pressure chamber (10).
  • the pressure chamber (10) is part of the pressure cylinder (8).
  • a piston (6) with a further axial pump channel (7) is located in the pressure cylinder (8).
  • the piston (6) is held in the upper rest position by the spring (9) at a stop.
  • the pressure chamber (10) is located between the piston (6) and the ball valve (11) and is connected to the upper pump channel (7).
  • the piston (6) has a smaller outer diameter than the inner diameter of the pressure cylinder (8), so that a gap (12) remains between the outer wall of the piston and the inner wall of the cylinder, which is sealed by the peripheral sealing body (13) of the piston.
  • the pressure cylinder (8) has an area (14) with a larger inside diameter, in which the sealing body (13) has no sealing effect.
  • a trigger element (15) is located on the piston (6) with the upper pump channel (7). From there, a riser pipe (16), which is connected to a pressure control valve (17), leads to a nozzle (18) in order to discharge the liquids to be atomized through the opening of the nozzle (18).
  • the function of the upper pump channel (7) and the riser pipe (16) form a common riser pipe which connects the pressure chamber to the nozzle.
  • the pressure control valve (17) is connected to the riser pipe (16) in such a way that it is at least partially flushed by the liquid.
  • the pressure control valve can be attached at any point within the common riser pipe, which is formed from the upper pump channel (7) and the riser pipe (16). In Figure 1, it is formed in the upper region of the riser pipe (16).
  • the plunger (20) is fixed to the piston (6) in the region (21) and has a star-shaped diameter, so that there is a space between the
  • Pressure chamber (10) and the upper pump channel (7) remains.
  • the tappet (20) In the rest position, the tappet (20) is far away from the ball valve (11), so that this valve is open with respect to the storage container if sufficient negative pressure is generated in the pressure chamber (10) and the valve is closed when the pressure there is correspondingly high is.
  • the liquid takes the following route through the pump attachment: First, it is pumped from the first pump channel (25) out of the storage vessel via the open ball valve (11) into the pressure chamber (10) and then reaches the pump channel (7). From there, the liquid passes through the riser pipe (16) with the pressure control valve (17) formed there and finally reaches the nozzle (18).
  • oligodynamically active substances are formed along the path that the liquid takes from the storage chamber to the nozzle.
  • These substances can be formed, for example, on the spring (9), on the wall of the upper pump channel (7) or the riser pipe (16), in the pressure control valve (17) and / or on the nozzle (18).
  • Means for sterilizing the incoming air are formed along the airway. These include, for example, sterility filters, membranes that are only permeable to air, bacteria-retaining materials, oligodynamically active substances, or microbiocidal substances or combinations thereof.
  • a sterility filter (24) is shown as an example in FIG.
  • the pump attachment (2) is firmly connected to the bottle neck (102) by means of a snap lock (3).
  • Figure 2 shows a variant of Figure 1, in which the pressure control valve (17) is formed near the transition region between the upper pump channel (7) and the riser pipe (16).
  • the result of this arrangement is that the area of the riser pipe (16) which lies between the upper end of the upper pump channel (7) and the pressure control valve (17) is greatly shortened compared to that of FIG. 1, whereas the area of the between the pressure control valve (17 ) and the opening the nozzle (18) is significantly extended.
  • the opening (26) is opened and the liquid from the lower region of the riser pipe (16), which is located in front of the pressure control valve (17), can pass it through the opening (26) in the upper area (26) of the riser pipe (16) flow.
  • the nozzle (18) is covered by an attachable cap (27).
  • the storage container is a bottle made of aluminum, as shown in FIG. 3.
  • Figure 4 shows the bottle neck enlarged.
  • the storage container (101) consists of the bottle neck (102), the bottle belly (103) and the concave bottle bottom (104).
  • the bottle neck has a flared shape (105). If necessary, an annular notch running perpendicular to the axis is formed at the beginning of the bottle neck, viewed from the direction of the bottle belly to the bottle opening, in order to be able to anchor a cap.
  • the bottle neck is generally narrower than the bottle belly, the outer diameter is preferably between 15 and 33 mm, particularly preferably 18 to 21 mm. In another embodiment, it is preferably 30 and 33 mm.
  • the inside diameter is preferably 12 to 28 mm, particularly preferably between 14 and 16 mm. In another embodiment, it is preferably 24 and 26 mm.
  • the bottle height is preferably 50 mm to 250 mm, particularly preferably 50 mm to 125 mm, most preferably 60 mm - 90 mm.
  • the wall of the bottle has a thickness of 0.3 to 0.5 mm, preferably 0.37 to 0.41 mm, in the wall and neck area.
  • the wall thickness of the floor area is 0.5 mm to 1.5 mm, preferably 0.8 to 1 mm.
  • the outside of the bottle can be painted and, if necessary, printed, the inside, including the bottle neck and its upper edge (106), can be coated with a synthetic varnish. It is preferably an epoxiphenol.
  • the lacquer is advantageous in order to increase the corrosion resistance of the bottle to the active substance formulation and at the same time to prevent the active substance formulation from taking on a metallic taste.
  • the top edge (106) of the bottle neck is rolled flat or in shape after formation. This increases the tightness between the bottle neck and the seal of the pump attachment.
  • the storage container is gas-diffusion-tight, so that the pharmaceutical stability of the active ingredient formulation cannot be reduced even by prolonged storage by diffusing gas

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Abstract

La présente invention concerne un atomiseur (1) destiné à l'administration nasale ou buccale d'un aérosol médical/pharmaceutique, la formulation d'agents actifs étant constamment maintenue dans des conditions stériles. L'atomiseur (1) selon l'invention est de préférence destiné à pulvériser des agents humidifiants, des agents pharmaceutiques, et des agents de traitement des plaies par voie nasale ou buccale.
EP01988629A 2000-10-28 2001-10-20 Atomiseur destine a des liquides Withdrawn EP1332004A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE20018518U 2000-10-28
DE20018518U DE20018518U1 (de) 2000-10-28 2000-10-28 Zerstäuber für Nasenspray
PCT/EP2001/012145 WO2002034411A1 (fr) 2000-10-28 2001-10-20 Atomiseur destine a des liquides

Publications (1)

Publication Number Publication Date
EP1332004A1 true EP1332004A1 (fr) 2003-08-06

Family

ID=7948248

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01988629A Withdrawn EP1332004A1 (fr) 2000-10-28 2001-10-20 Atomiseur destine a des liquides

Country Status (7)

Country Link
US (2) US20020074429A1 (fr)
EP (1) EP1332004A1 (fr)
JP (1) JP2004512171A (fr)
AU (1) AU2002221710A1 (fr)
CA (1) CA2425633A1 (fr)
DE (1) DE20018518U1 (fr)
WO (1) WO2002034411A1 (fr)

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GB0204829D0 (en) * 2002-03-01 2002-04-17 Glaxo Group Ltd A fluid dispensing device
DE60227712D1 (de) * 2002-09-03 2008-08-28 Pharmacure Health Care Ab Nasensprays
DE20218974U1 (de) 2002-12-07 2003-07-10 Boehringer Ingelheim Pharma Zerstäuber für Flüssigkeiten
CA2550811C (fr) * 2003-12-24 2012-05-01 Jane Hirsh Formulations thermostables et methodes de mise au point desdites formulations
DE102004034629A1 (de) * 2004-06-14 2006-01-05 Seaquist Perfect Dispensing Gmbh Vorrichtung und Sprühkopf zur Zerstäubung einer vorzugsweise kosmetischen Flüssigkeit sowie Verfahren zum Herstellen einer derartigen Vorrichtung
DE102005029746B4 (de) * 2005-06-24 2017-10-26 Boehringer Ingelheim International Gmbh Zerstäuber
DE102007023012A1 (de) * 2007-05-15 2008-11-20 Boehringer Ingelheim Pharma Gmbh & Co. Kg Zerstäuber und Filter
EP2077132A1 (fr) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispositif distributeur, dispositif de stockage et procédé pour la distribution d'une formulation
US10011906B2 (en) 2009-03-31 2018-07-03 Beohringer Ingelheim International Gmbh Method for coating a surface of a component
EP3508239B1 (fr) 2009-05-18 2020-12-23 Boehringer Ingelheim International GmbH Adaptateur, dispositif d'inhalation et pulvérisateur
WO2011064163A1 (fr) 2009-11-25 2011-06-03 Boehringer Ingelheim International Gmbh Nébuliseur
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
UA107097C2 (en) 2009-11-25 2014-11-25 Бьорінгер Інгельхайм Інтернаціональ Гмбх Dispenser
JP5874724B2 (ja) 2010-06-24 2016-03-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
EP2694220B1 (fr) 2011-04-01 2020-05-06 Boehringer Ingelheim International GmbH Appareil médical pourvu d'un récipient
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
WO2013152894A1 (fr) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Pulvérisateur comprenant des moyens de détrompage
KR101496970B1 (ko) * 2012-04-20 2015-03-02 (주)연우 비강세척수 분사용기
EP3030298B1 (fr) 2013-08-09 2017-10-11 Boehringer Ingelheim International GmbH Nébuliseur
ES2836977T3 (es) 2013-08-09 2021-06-28 Boehringer Ingelheim Int Nebulizador
ES2874029T3 (es) 2014-05-07 2021-11-04 Boehringer Ingelheim Int Nebulizador
ES2954961T3 (es) 2014-05-07 2023-11-27 Boehringer Ingelheim Int Unidad, nebulizador y método
UA121114C2 (uk) 2014-05-07 2020-04-10 Бьорінгер Інгельхайм Інтернаціональ Гмбх Небулайзер, індикаторний пристрій і контейнер
CN104984447A (zh) * 2015-07-30 2015-10-21 中山市美捷时包装制品有限公司 一种鼻腔喷雾用的喷雾装置
US10744520B1 (en) * 2017-01-31 2020-08-18 Packaging Concepts Associates Holdings, Inc. Nasal sprayer with child resistant safety lock assembly
ES2942417T3 (es) 2017-04-28 2023-06-01 Softhale Nv Dispositivo de inhalación
WO2018222769A1 (fr) * 2017-06-01 2018-12-06 Counteract, Llc Bouchon de bouteille de médicament sous ordonnance susceptible d'administrer un agent d'inversion de surdose d'opioïde
US11759586B1 (en) * 2022-04-13 2023-09-19 Ferrer Medical Innovations, LLC Nasal spray bottle with improved nozzle and system of application

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Also Published As

Publication number Publication date
US20040004138A1 (en) 2004-01-08
DE20018518U1 (de) 2001-02-01
AU2002221710A1 (en) 2002-05-06
CA2425633A1 (fr) 2003-04-07
WO2002034411A1 (fr) 2002-05-02
US20020074429A1 (en) 2002-06-20
JP2004512171A (ja) 2004-04-22

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Owner name: BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG

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