EP1324987A1 - Indazoles a action analogue a l'hormone thyroidienne, leur procede de fabrication et leur utilisation dans des medicaments - Google Patents
Indazoles a action analogue a l'hormone thyroidienne, leur procede de fabrication et leur utilisation dans des medicamentsInfo
- Publication number
- EP1324987A1 EP1324987A1 EP01978337A EP01978337A EP1324987A1 EP 1324987 A1 EP1324987 A1 EP 1324987A1 EP 01978337 A EP01978337 A EP 01978337A EP 01978337 A EP01978337 A EP 01978337A EP 1324987 A1 EP1324987 A1 EP 1324987A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- alkyl
- hydrogen
- different
- hydroxy
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
Definitions
- R 20 and R 21 together represent oxygen, or are each the same or different and represent hydrogen, halogen, hydroxy, (Cj-Cg) alkyl, (C r C 6 ) alkoxy or the radical -NR 15 R 16 and
- aryl stands for an aromatic radical having preferably 6 to 10 carbon atoms.
- Preferred aryl groups are phenyl and naphthyl.
- Cycloalkyl in the context of the invention represents a cycloalkyl group with preferably 3 to 8, 3 to 7 or 3 to 6 carbon atoms. Examples and preferably mentioned are: cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl.
- the compounds according to the invention can exist in stereoisomeric forms which are either like image and mirror image (enantiomers) or which are not obtained like image and mirror image (diastereomers).
- the invention relates both to the enantiomers or diastereomers and to their respective mixtures.
- the racemic forms can be uniformly standardized into the stereoisomers
- Z represents CH 2 or in particular oxygen
- Example 8 ⁇ [ethoxy (oxo) acetyl] amino ⁇ -2,6-dimethylphenoxy) -3- ⁇ ropyl-1H-indazol-1-yl] (oxo) - acetates (Example 8). In addition, 18 mg (40%) of the ethyl - ( ⁇ 3,5-dimethyl-4 - [(3-propyl-1H-indazol-5-yl) oxy] phenyl ⁇ amino) (oxo) acetate (Example 8 a) won.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne de nouveaux dérivés de l'indazole, de formule (I), dans laquelle, Z désigne O, S, CH2, CHF ou CF2, et où R1-R7 ont les significations spécifiées dans la revendication 1, ces dérivés ayant une action analogue à l'hormone thyroïdienne. L'invention concerne en outre leur procédé de fabrication et leur utilisation dans des médicaments.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10046029A DE10046029A1 (de) | 2000-09-18 | 2000-09-18 | Indazole |
DE10046029 | 2000-09-18 | ||
PCT/EP2001/010204 WO2002022586A1 (fr) | 2000-09-18 | 2001-09-05 | Indazoles a action analogue a l'hormone thyroidienne, leur procede de fabrication et leur utilisation dans des medicaments |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1324987A1 true EP1324987A1 (fr) | 2003-07-09 |
Family
ID=7656569
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP01978337A Withdrawn EP1324987A1 (fr) | 2000-09-18 | 2001-09-05 | Indazoles a action analogue a l'hormone thyroidienne, leur procede de fabrication et leur utilisation dans des medicaments |
Country Status (6)
Country | Link |
---|---|
US (1) | US6608049B2 (fr) |
EP (1) | EP1324987A1 (fr) |
AU (1) | AU2002210484A1 (fr) |
CA (1) | CA2422353A1 (fr) |
DE (1) | DE10046029A1 (fr) |
WO (1) | WO2002022586A1 (fr) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2356889C2 (ru) | 2003-07-17 | 2009-05-27 | Плекссикон, Инк. | Соединения, являющиеся активными по отношению к рецепторам, активируемым пролифератором пероксисом |
WO2005051298A2 (fr) * | 2003-11-19 | 2005-06-09 | Metabasis Therapeutics, Inc. | Nouvelles substances thyromimetiques contenant du phosphore |
BRPI0508036A (pt) | 2004-02-27 | 2007-07-17 | Hoffmann La Roche | derivados fundidos de pirazola |
EP1720878A1 (fr) | 2004-02-27 | 2006-11-15 | F.Hoffmann-La Roche Ag | Derives pyrazolo heteroaryl-condenses |
JP2007523937A (ja) | 2004-02-27 | 2007-08-23 | エフ.ホフマン−ラ ロシュ アーゲー | インダゾール誘導体およびそれを含む医薬組成物 |
US7026846B1 (en) * | 2004-07-09 | 2006-04-11 | Analog Devices, Inc. | Synthesizer structures and methods that reduce spurious signals |
BRPI0514017A (pt) * | 2004-08-03 | 2008-05-27 | Wyeth Corp | indazóis úteis no tratamento de doenças cardiovasculares |
EP1647549A1 (fr) * | 2004-10-14 | 2006-04-19 | Laboratoire Theramex | Indazoles, benzisoxazoles et benzisothiazoles en tant qu'agents oestrogéniques |
US7601847B2 (en) | 2004-10-26 | 2009-10-13 | Wyeth | Preparation and purification of 4-(indazol-3-yl)phenols |
CA2606498C (fr) * | 2005-05-26 | 2016-08-09 | Metabasis Therapeutics, Inc. | Nouvelles substances thyromimetiques contenant de l'acide phosphinique |
US20090232879A1 (en) | 2005-05-26 | 2009-09-17 | Metabasis Therapeutics, Inc. | Thyromimetics for the Treatment of Fatty Liver Diseases |
US20060292194A1 (en) * | 2005-06-24 | 2006-12-28 | Thomas Lavin | Treatment for burns and adipose deposits using thyroid hormone compound in a human |
GB0513692D0 (en) * | 2005-07-04 | 2005-08-10 | Karobio Ab | Novel pharmaceutical compositions |
MX2008002588A (es) | 2005-08-25 | 2008-03-18 | Hoffmann La Roche | Inhibidores de p38-map-cinasa y los metodos para utilizarlos. |
CA2655913A1 (fr) * | 2006-06-28 | 2008-01-03 | Sanwa Kagaku Kenkyusho Co., Ltd. | Nouveau derive heterocyclique bicyclique a 5-6 systemes et son utilisation pharmaceutique |
TWI365185B (en) | 2008-07-24 | 2012-06-01 | Lilly Co Eli | Amidophenoxyindazoles useful as inhibitors of c-met |
JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
WO2018094265A2 (fr) | 2016-11-21 | 2018-05-24 | Viking Therapeutics, Inc. | Méthodes de traitement de glycogénose |
BR112019025659A2 (pt) | 2017-06-05 | 2020-08-25 | Viking Therapeutics, Inc. | composições para o tratamento de fibrose |
US10836769B2 (en) | 2018-02-26 | 2020-11-17 | Gilead Sciences, Inc. | Substituted pyrrolizine compounds and uses thereof |
CA3094167A1 (fr) | 2018-03-22 | 2019-09-26 | Viking Therapeutics, Inc. | Formes cristallines et procedes de production de formes cristallines d'un compose |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2032171A1 (de) * | 1970-06-30 | 1972-01-13 | Agfa Gevaert AG, 5090 Leverkusen | Lichtempfindliches farbfotografisches Material |
GB8501372D0 (en) | 1985-01-18 | 1985-02-20 | Smith Kline French Lab | Chemical compounds |
DK0580550T3 (da) | 1992-07-21 | 1998-02-02 | Ciba Geigy Ag | Oxamidsyrederivater som hypercholesterolæmiske midler |
US6266622B1 (en) | 1995-12-13 | 2001-07-24 | Regents Of The University Of California | Nuclear receptor ligands and ligand binding domains |
US5883294A (en) | 1997-06-18 | 1999-03-16 | The Regeants Of The University Of California | Selective thyroid hormone analogs |
DE19830431A1 (de) * | 1998-07-08 | 2000-01-13 | Hoechst Marion Roussel De Gmbh | Sulfonylamino-carbonsäure-N-arylamide als Guanylatcyclase-Aktivatoren |
CN1314893A (zh) * | 1998-07-23 | 2001-09-26 | 史密丝克莱恩比彻姆公司 | Il-8受体拮抗剂 |
YU63301A (sh) | 1999-03-01 | 2004-09-03 | Pfizer Products Inc. | Oksaminske kiseline i njihovi derivati kao ligandi tiroidnog receptora |
CO5160290A1 (es) | 1999-03-29 | 2002-05-30 | Novartis Ag | Derivados de acido fenoxifeniloxamico sustituido . |
YU54202A (sh) * | 2000-01-18 | 2006-01-16 | Agouron Pharmaceuticals Inc. | Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije |
-
2000
- 2000-09-18 DE DE10046029A patent/DE10046029A1/de not_active Withdrawn
-
2001
- 2001-09-05 AU AU2002210484A patent/AU2002210484A1/en not_active Abandoned
- 2001-09-05 CA CA002422353A patent/CA2422353A1/fr not_active Abandoned
- 2001-09-05 EP EP01978337A patent/EP1324987A1/fr not_active Withdrawn
- 2001-09-05 WO PCT/EP2001/010204 patent/WO2002022586A1/fr not_active Application Discontinuation
- 2001-09-18 US US09/956,566 patent/US6608049B2/en not_active Expired - Fee Related
Non-Patent Citations (1)
Title |
---|
See references of WO0222586A1 * |
Also Published As
Publication number | Publication date |
---|---|
US6608049B2 (en) | 2003-08-19 |
AU2002210484A1 (en) | 2002-03-26 |
WO2002022586A1 (fr) | 2002-03-21 |
CA2422353A1 (fr) | 2003-03-14 |
DE10046029A1 (de) | 2002-03-28 |
US20020193610A1 (en) | 2002-12-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
AK | Designated contracting states |
Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK RO SI |
|
17P | Request for examination filed |
Effective date: 20030422 |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: BAYER HEALTHCARE AG |
|
RBV | Designated contracting states (corrected) |
Designated state(s): DE ES FR GB IT |
|
17Q | First examination report despatched |
Effective date: 20060814 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20061228 |