EP1315125A2 - Procédé et système pour détecter des maladies pulmonaires - Google Patents

Procédé et système pour détecter des maladies pulmonaires Download PDF

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EP1315125A2
EP1315125A2 EP02257868A EP02257868A EP1315125A2 EP 1315125 A2 EP1315125 A2 EP 1315125A2 EP 02257868 A EP02257868 A EP 02257868A EP 02257868 A EP02257868 A EP 02257868A EP 1315125 A2 EP1315125 A2 EP 1315125A2
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anatomical
models
disease
regions
information
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EP1315125B1 (fr
EP1315125A3 (fr
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Joseph Leagrand Mundy
Colin Craig Mcculloch
Ricardo Scott Avila
Shannon Lee Hastings
Robert August Kaucic Jr.
William Edward Lorensen
Matthew William Turek
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General Electric Co
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General Electric Co
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    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30061—Lung

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  • This invention relates to a method and system for processing medical image data to aid in the detection and diagnosis of disease, and more particularly, to a method and system for detecting lung disease in medical images obtained from a x-ray computed tomography (CT) system.
  • CT computed tomography
  • a x-ray chest radiograph system is the more commonly used diagnostic tool useful for the purpose of detecting lung disease in humans.
  • Lung disease such as bronchitis, emphesema and lung cancer are also detectable in chest radiographs and CT.
  • CT systems generally provide over 80 separate images for a single CT scan thereby providing a considerable amount of information to a radiologist for use in interpreting the images and detecting suspect regions that may indicate disease.
  • Suspect regions are defined as those regions a trained radiologist would recommend following through subsequent diagnostic imaging, biopsy, functional lung testing, or other methods.
  • the considerable volume of data presented by a single CT scan presents a time-consuming process for radiologists.
  • Conventional lung cancer screening generally involves a manual interpretation of the 80 or more images by the radiologist. Fatigue is therefore a significant factor affecting sensitivity and specificity of the human reading.
  • emphysema it is difficult for a radiologist to classify the extent of disease progression by only looking at the CT images. Quantitative analysis of the anatomy is required.
  • Vessel extraction has been attempted using gray-level thresholding, fuzzy clustering, and three- dimensional seeded region growing).
  • Nodule detection has been done using template matching, genetic algorithms, gray-level thresholding, the N-Quoit filter, region growing, and edge-gradient techniques.
  • What is needed is a robust method and system for processing image data to produce quantitative data to be used in detecting disease. What is further needed is a method and system that provides interpretative results based on expert knowledge of a disease as well as the scanner capabilities and characteristics. Additionally, there is a requirement for the ability to track a disease's progression/regression resulting from drug therapy.
  • a method for processing medical images for use in the detection and diagnosis of disease comprises classifying regions of interest within the medical images based on a hierarchy of anatomical models and signal models of signal information of an image acquisition device used to acquire the medical images.
  • the anatomical models are derived to be representative of anatomical information indicative of a given disease.
  • a computer-aided system for use in the diagnosis and detection of disease.
  • the system comprises an image acquisition device for acquiring a plurality of image data sets and a processor adapted to process the image data sets.
  • the processor is adapted to classify selected tissue types within the image data sets based on a hierarchy of signal and anatomical models and the processor is further adapted to differentiate anatomical context of the classified tissue types for use in the diagnosis and detection of disease.
  • System 100 includes an imaging device 110, which can be selected from a number of medical imaging devices known in the art for generating a plurality of images. Most commonly, computed tomography (CT) and magnetic resonance imaging (MRI) systems are used to generate a plurality of medical images.
  • CT computed tomography
  • MRI magnetic resonance imaging
  • a patient lies horizontal and is exposed to a plurality of x-rays measured with a series of X-ray detectors.
  • a beam of x-rays passes through a particular thin cross-section or "slice" of the patient.
  • the detectors measure the amount of transmitted radiation. This information is used to compute the x-ray attention coefficient for sample points in the body.
  • a gray scale image is then constructed based upon the calculated x-ray attenuation coefficients. The shades of gray in the image contrast the amount of x-ray absorption of every point within the slice.
  • the slices obtained during a CT session can be reconstructed to provide an anatomically correct representation of the area of interest within the body that has been exposed to the x-rays.
  • the patient is placed inside a strong magnetic field generated by a large magnet.
  • Magnetized protons within the patient such as hydrogen atoms, align with the magnetic field produced by the magnet.
  • a particular slice of the patient is exposed to radio waves that create an oscillating magnetic field perpendicular to the main magnetic field.
  • the slices can be taken in any plane chosen by the physician or technician (hereinafter the "operator") performing the imaging session.
  • the protons in the patient's body first absorb the radio waves and then emit the waves by moving out of alignment with the field. As the protons return to their original state (before excitation), diagnostic images based upon the waves emitted by the patient's body are created.
  • MR image slices can be reconstructed to provide an overall picture of the body area of interest. Parts of the body that produce a high signal are displayed as white in an MR image, while those with the lowest signals are displayed as black. Other body parts that have varying signal intensities between high and low are displayed as some shade of gray.
  • the images are generally segmented.
  • the segmentation process classifies the pixels or voxels of an image into a certain number of classes that are homogeneous with respect to some characteristic (i.e. intensity, texture, etc.). For example, in a segmented image of the brain, the material of the brain can be categorized into three classes: gray matter, white matter, and cerebrospinal fluid. Individual colors can be used to mark regions of each class after the segmentation has been completed. Once the segmented image is developed, surgeons can use the segmented images to plan surgical techniques.
  • creating a segmented CT or MR image involves several steps.
  • a data set is created by capturing CT or MR slices of data.
  • a gray scale value is then assigned to each point in the data set and different types of tissues will have different gray scale values.
  • Each type of material in the data is assigned a specific value and, therefore, each occurrence of that material has the same gray scale value. For example, all occurrences of bone in a particular image may appear in a particular shade of light gray. This standard of coloring allows the individual viewing the image to easily understand the objects being represented in the images.
  • FIG. 1 illustrates a medical imaging system 100 to which embodiments of the invention are applicable.
  • the system includes an imaging device 110, a processor 120 and an interface unit 130.
  • Imaging device 110 is adapted to generate a plurality of image data sets 240 and is, for example, a computed tomography (CT) or magnetic resonance (MR) scanner.
  • CT computed tomography
  • MR magnetic resonance
  • Processor 120 is configured to perform computations in accordance with embodiments of the present invention which will be described in greater detail with reference to Figures 2-4.
  • Processor 120 is also configured to perform computation and control functions for well-known image processing techniques such as reconstruction, image data memory storage, segmentation and the like.
  • Processor 120 may comprise a central processing unit (CPU) such as a single integrated circuit, such as a microprocessor, or may comprise any suitable number of integrated circuit devices and/or circuit boards working in cooperation to accomplish the functions of a central processing unit.
  • processor 120 desirably includes memory.
  • Memory within processor 120 may comprise any type of memory known to those skilled in the art. This includes Dynamic Random Access Memory (DRAM), Static RAM (SRAM), flash memory, cache memory, etc. While not explicitly shown in FIG. 1, the memory may be a single type of memory component or may be composed of many different types of memory components.
  • Processor 120 is also capable of executing the programs contained in memory and acting in response to those programs or other activities that may occur in the course of image acquisition and image viewing.
  • adapted to refers to mechanical or structural connections between elements to allow the elements to cooperate to provide a described effect; these terms also refer to operation capabilities of electrical elements such as analog or digital computers or application specific devices (such as an application specific integrated circuit (ASIC)) that are programmed to perform a sequel to provide an output in response to given input signals.
  • ASIC application specific integrated circuit
  • Interface unit 130 is coupled to processor 120 and is adapted to allow human users to communicate with system 100.
  • Processor 120 is further adapted to perform computations that are transmitted to interface unit 130 in a coherent manner such that a human user is capable of interpreting the transmitted information.
  • Transmitted information may include images in 2D or 3D, color and gray scale images, and text messages regarding diagnosis and detection information.
  • Interface unit 130 may be a personal computer, an image work station, a hand held image display unit or any convention image display platform generally grouped as part of a CT or MRI system.
  • All data gathered from multiple scans of the patient is to be considered one data set.
  • Each data set can be broken up into smaller units, either pixels or voxels.
  • the image is made up of units called pixels.
  • a pixel is a point in two-dimensional space that can be referenced using two dimensional coordinates, usually x and y.
  • Each pixel in an image is surrounded by eight other pixels, the nine pixels forming a three-by-three square. These eight other pixels, which surround the center pixel, are considered the eight-connected neighbors of the center pixel.
  • the image is displayed in units called voxels.
  • a voxel is a point in three-dimensional space that can be referenced using three-dimensional coordinates, usually x, y and z. Each voxel is surrounded by twenty-six other voxels. These twenty-six voxels can be considered the twenty-six connected neighbors of the original voxel.
  • a computer-aided system for use in the diagnosis and detection of disease comprises an image acquisition device for acquiring a plurality of image data sets and a processor adapted to classify selected tissue types within the image data sets based on a hierarchy of signal and anatomical models.
  • the processor is further adapted to differentiate anatomical context of the classified tissue types for use in the diagnosis and detection of a selected disease.
  • the system further comprises an interface unit for presenting the classified tissue types within the image data sets and anatomical context of the classified tissue types for aiding an interpretation of the processed image data sets.
  • the anatomical models are parametric, mathematical representations of anatomical tissues.
  • the anatomical context comprises at least one of lung nodules indicative of lung cancer, healthy lung tissue, diseased lung tissue indicative of chronic obstructive pulmonary disease (COPD) and other pathological descriptions of tissue that can be characterized by radiologists and further modeled mathematically. Further discussion of anatomical context and mathematical modeling will be provided with reference to Figure 4.
  • COPD chronic obstructive pulmonary disease
  • the imaging device is a x-ray CT scanner.
  • a CT system is particularly well adapted to acquire a plurality of images, or alternatively slices, of a region of interest.
  • the imaging object is a lung.
  • MR magnetic resonance
  • other regions of interest other than the lung may be the imaging object, e.g. the heart, colon, limbs, breast or brain.
  • the processing functions performed by processor 120 would be adapted to classify tissue types of interest in these other imaging objects.
  • An embodiment for a method for detecting disease from the plurality of medical images comprises the steps of acquiring the image data, processing of the acquired image data to define the lung region; computing low level features in the image using the known characteristics of the imaging device and the imaging process; grouping regions in the image, based on their features and an information object hierarchy describing their features, into anatomical structures; and, deciding if any of the grouped regions represents an area which is suspicious for a lung disease.
  • the method further comprises presenting the areas identified as suspicious for lung disease.
  • the presenting step comprises presenting the anatomical context (e.g. lung nodule, diseased tissue, healthy tissue) and a decision process by which the suspicious areas were identified.
  • a method for characterizing tissue in medical images for use in disease diagnosis and detection comprises computing an information object hierarchy of increasing complexity to characterize anatomical tissue.
  • the object hierarchy contains models, or alternatively mathematical representations, based on characteristics of an image acquisition device used in acquiring the images and based on anatomical characteristics of a selected region of interest and a specified disease.
  • Image data is acquired at 210. These images are passed to processor 120 ( Figure 1) for processing steps 220 -280 of Figure 2.
  • the area of the images that represents the lung is determined by selection of various known segmentation techniques or, alternatively by an exemplary embodiment of pleural space segmentation which will be discussed in greater detail below with reference to Figure 3.
  • Resulting from step 220, input pixels from a CT scan are first classified to be either in the lung cavity or outside the lung. The input pixels are acquired from either a two-dimensional CT scan data set or, alternatively, from a three-dimensional CT scan data set.
  • processor 120 then computes low-level signal models from the gray scale values of the image within the lung region.
  • These models may include (but are not limited to) compact, bright objects; compact, dark objects; and long, bright objects.
  • the low-level signal models are mathematical descriptions of structures being imaged after the measurement process of the scanner modifies them.
  • Signal model processing continues at 250 to gain more information regarding a region of pixels in the image.
  • different signal models are competed against each other in order to best explain a region of pixels in the images.
  • the competition is desirably carried out by performing comparisons between the signal models using the known statistical-based process of Bayes Factors. It is to be appreciated that other decision or statistical based methods may also be used.
  • An exemplary embodiment using Bayes Factors will be described in greater detail below and with reference to Figure 4.
  • a further grouping process occurs at steps 260 and 270. This involves grouping the low-level models into anatomical structures such as particular areas of the lung. Again, the decision process involves competing anatomical models desirably using Bayes Factors in order to make an optimal decision as to model applicability.
  • results are presented. Results are based on the information provided by the low-level signal models and the anatomical models in order to provide qualitative and quantitative information regarding suspicion for lung disease. Decisions at this level are made in the same way that a radiologist might make decisions regarding a lung nodule because the system has both low-level signal knowledge and anatomical context.
  • a lung segmentation process is provided that automatically identifies the boundaries of the pleural space in a Computed Tomography (CT) data set.
  • CT Computed Tomography
  • the boundary is either a set of two-dimensional (2D) contours in a slice plane or a three-dimensional (3D) triangular surface that covers the entire volume of the pleural space.
  • the extracted boundary can be subsequently used to restrict Computer Aided Detection (CAD) techniques to the pleural space. This will reduce the number of false positives that occur when a lung nodule detection technique is used outside the pleural space.
  • CAD Computer Aided Detection
  • Steps 310-316 correspond to steps 310-316 for the 3D surface.
  • the segmentation process enables an automatic selection of all algorithm parameters based on the specific anatomy of the lung and the CT examination protocol. Further, the island removal is performed in three consecutive second passes, each in a different plane. It is to be appreciated that identifying the lung region initially allows a reduction in computation time and complexity for the downstream measurements.
  • the hierarchy of models comprise models of various levels comprising signal model data, geometric model data, and anatomical model data. Those pixels that have been classified as being inside the lung region at step 220 ( Figure 1) are modeled at several levels of modeling structure, herein after referred to as the hierarchy.
  • models refer generally to mathematical representations or, alternatively, mathematical translations.
  • characteristics of the imaging device are translated into mathematical representations.
  • Characteristics of the imaging device that are of interest are those characteristics that generally affect the display and resolution of the images or otherwise affect a radiologist's interpretation of regions in the image.
  • the scanner point spread function is a measurable indicator of the image formation process and may be mathematically modeled.
  • Other indicators of the image formation process include X-ray density, brightness, resolution and contrast.
  • fitted shape models are derived to explain the geometry and intensity surface of various tissues.
  • Shape and geometric model information is derived from anatomical information and expert radiologist observations which will be described in greater detail with respect to Figure 4.
  • low-level pixel information is transformed into anatomical information.
  • This anatomical information is a classification of all pixels into lung tissue types, eg. blood vessel, lung matrix, and lung cancer nodule.
  • the models for the intermediate level are generally derived from pathological information for a region of interest (e.g. lung) and a specific disease (e.g. lung cancer or COPD) obtained from expert information, for example radiologists that have observed recurring characteristics for certain types of lung disease.
  • the expert information is desirably from a radiologist or a plurality of radiologists experienced with the region of interest and detection of the specific disease.
  • lung nodules and vascular structure are indicators of lung disease such as lung cancer.
  • lung parenchyma metrics are also indicators of lung disease.
  • a set of geometric and shape characteristics are obtained.
  • lung cancer nodules are generally compact, bright and spherical in nature.
  • lung cancer nodules that are likely to be cancerous tend to be spiculated (spidery vessel structures).
  • these characterizations of disease, such as lung cancer nodules are mathematically represented as nodule model 470 and vessel model 480 as shown in Figure 4.
  • lung matrix tissue which can be considered background to the vessels and nodules and for embodiments of the present invention is also modeled as the mathematical representation of lung matrix tissue model 490.
  • nodule model 470, vessel model 480 and lung matrix tissue model 490 represent a high level explanation in the hierarchy used to distinguish various lung tissues.
  • Each of the high level models are further defined at low and intermediate levels.
  • nodules are generally spherical and bright (measurable in Hounsfeld units).
  • a shape model representing intensity region formation 440 and a signal model for step edge detection 410 are derived mathematically to enable identification of a potential nodule.
  • spiculated nodules tend to have a compact core structure fed by one or more vessels and also having a spidery or spiculated structure.
  • a shape model representing intensity ribbon formation 450 and a signal model representing fold edge detection 420 similarly enable identification of a potential spiculated nodule.
  • Background lung tissue is also similarly defined by low and intermediate levels of a texture region formation model 460 and a sub-resolution texture detection model 430.
  • step edge detection 410 pixel information is analyzed at the output of an image formation process (240 of Figures 1 and 2).
  • the tissue boundaries are identified using convolution operators. Nodule candidates are localized by convolving the images with differential kernels defined by the signal impulse response of the imaging device.
  • images acquired from a GE LightSpeed Scanner were used and a Canny edge detector was used with a smoothing parameter of 1.1 pixels.
  • the vascular structure is localized by convolving the images with differential kernels defined by the signal impulse response of the imaging device using fold edge detection 420.
  • fold edge detection 420 In this embodiment using images acquired from a GE LightSpeed Scanner, a fold edge detector was used with a smoothing parameter of 1.5 pixels.
  • Background tissue is represented as sub-resolution texture by sub-resolution texture detection 430.
  • Background tissue is localized by identifying regions of low intensity. Convolution kernels defined by the signal impulse response of the imaging device are used to identify potential background regions. In this embodiment using images acquired from a GE LightSpeed Scanner, a Canny edge detector is used with a smoothing parameter of 1.1 pixels. At this stage of processing, the list of background regions is trimmed by thresholding at an average intensity of 520.
  • An alternate localization procedure consists of modeling the background tissue as generalized intensity cylinders with random orientation. In this implementation, localization is achieved by comparing the output of generalized-cylinder model with the image intensities.
  • Putative nodule candidates are formed by grouping the output of the signal model stage into regions at intensity region formation step 440. Region grouping is performed by extrapolating edge segments perpendicular to the edge gradient. Edges ending near vertices associated with other edges are connected to form regions. In this implementation, the distance threshold for connecting edge segments is 4 pixels.
  • the vascular structure is obtained at intensity ribbon formation step 450 by linking together the output of the fold edge detection 420.
  • a width of the chain is defined by locating the nearest step-edge on each side in a direction perpendicular to the chain direction.
  • a set of intensity ribbons is defined. These ribbons are implicitly defined by the centerline of the fold-edges and the width of the fold along its entire length. These ribbons are considered “candidate vessels", that is, objects which may be defined as blood vessels in the next level of the hierarchy.
  • background lung tissue and lung matrix tissue are modeled.
  • Background lung tissue is obtained by grouping together regions output by the signal operators. Regions are formed by extrapolating edge segments perpendicular to the edge gradient. Edges ending near vertices associated with other edges are connected to form regions.
  • the distance threshold for connecting edge segments is 4 pixels.
  • each region is a candidate nodule, and it must be decided whether the region, with an appropriate model on pixel intensities and region shape, is a better explanation of its interior pixels than any possible vessel or background explanation.
  • the two models are compared at step 500 using the Bayes Factor.
  • the competition framework is a pair wise comparison of the modeled information: nodule vs. vessel, and nodule vs. background. If the nodule "wins" each competition, then it is considered a suspicious region and is reported as such.
  • Bayes Factors refer to a known decision mechanism to ensure that the optimal decision is made given the input parameters. Applying the Bayes Factor to embodiments of the present invention provides that optimal decisions will be made given the statistical models of the shapes and signals provided by the radiologists' expert observations. This optimality assumes the statistical models of each anatomy type represent all the relevant knowledge embodied in a trained radiologist, and that the radiologist acts in a rational manner as defined by the Bayes Factor mechanism. Thus, the hierarchy of information enables processing to make a same decision as a radiologist would make regarding a region or nodule. Also, as used herein Bayes Factors will be used interchangeably herein with the term "Bayesian model competition".
  • a patch of pixels around the candidate is considered.
  • this patch is defined as the union of the candidate nodule and each conflicting ribbon, in turn.
  • the patch is defined as all pixels below a pre-specified intensity threshold within a pre-specified radius of the geometric center of the candidate, unioned with the candidate nodule. The radius is desirably set to 10 pixels, and the intensity threshold is desirably set to 520 CT units.
  • b) indicates the conditional probability distribution on the random variable a given the value of the random variable b.
  • the error term ⁇ i is normally distributed with zero mean and fixed variance, estimated off-line from true nodule data.
  • off-line estimation refers to known information learned or known beforehand, such as chances or likelihood information.
  • Spans are defined at one-pixel separation along the chain, and each span's intensity data is modeled independently according to the above model. The error term is again normally distributed.
  • the background model is defined as independent normal data at each pixel with unknown mean and fixed variance, estimated off-line from true background data. This data is gathered by an expert and the variance is estimated using the usual normal-model unbiased estimate.
  • Prior distributions are defined on all intensity model parameters as normal distributions with means and covariance matrices estimated off-line from manually segmented intensity data.
  • Prior distributions on shape parameters are defined as uniform distributions on key shape characteristics like nodule aspect ratio and size.
  • Prior probabilities on each model are determined via a known scanner parameter known as Receiver Operating Characteristic curves according to pre-specified sensitivity and specificity targets.
  • x , ⁇ 1 , ⁇ 2 ) p ( M 2
  • x , ⁇ 1 , ⁇ 2 ) p ( M 2
  • x , ⁇ 1 , ⁇ 2 ) p ( x
  • ⁇ 1 , M 1) p ( ⁇ 1
  • M 1) p ( ⁇ 2
  • ⁇ 2 , M 2) p ( ⁇ 2
  • M 2) p ( ⁇ 1
  • ⁇ 1 , M 1) p ( ⁇ 1
  • ⁇ 2 , M 2) is assumed equal to one.
  • the Bayes factor is necessarily greater than zero, and it indicates evidence for model 1 if the factor is greater than one (and vice versa).
  • Candidate nodules which give Bayes factors greater than one in both competitions are deemed suspicious, and are superimposed the CT data in a visualization tool (presenting step 280 of Figure 2), The characteristics of these suspicious nodules are also stored for further follow-up.
  • the competition framework provides a robust method for making a model selection decision. Modeling the anatomy in the images improves the robustness of the image measurements and allows results to be presented to doctors in the context of the anatomy.
  • the anatomical models are easily explained to physicians and their expert knowledge is coherently incorporated into the system (in the form of mathematical approximations of anatomical features).
  • the lowest level of the modeling hierarchy relies on time-tested image formation and understanding techniques which are firmly grounded in human visual perception.
  • Anatomical models are chosen via Bayes Factors, enable optimal decision given our statistical models.
  • the results are reported to a radiologist or doctor (hereinafter "user") in a manner that the user receives anatomical context, reasons for the decision of whether the region is of a particular type (nodule or vessel), and information of importance to the user.
  • Information of radiological importance are, for example, size of nodule, number of vessels, evidence of spiculation, chances/likelihood of cancer or disease, brightness measurements and other characteristic information related to the disease at issue.
  • Processor 120 of Figure 1 is adapted to perform the computations needed to support this reporting functionality.
  • processor 120 is adapted to allow for user queries regarding particular regions of interest such as pointing to a region and receiving information such as size, number of vessels and brightness for the selected region.
  • lung cancer detection and specifically to the distinction between lung nodules and vessels.
  • additional lung disease characteristics are similarly modeled such as the low-density, sponge-like texture which is generally characteristic of emphysema.
  • anatomical feature descriptions are obtained by experts (e.g. radiologists) and mathematically represented as a hierarchy.
  • models are derived for diseases that occur in other areas, such as the brain, colon and heart.
  • the hierarchy of models may be used in known neural network techniques as the training data to identify low and intermediate information and prior distributions. It is desirable that the Bayes Factor analysis be applied at the higher levels to provide useful and interpretative diagnosis data and the decision process.
  • processor 120 is further adapted to store the anatomical context and processed image data sets to be searched and retrieved remotely .
  • the information developed at each level in the model hierarchy is stored in systems used for medical archives, medical search and retrieval systems and alternate medical disease reporting systems.
  • information that may be searched and retrieved include: pathological and anatomical models derived for characteristics of diseases, images representative of the diseases, and results of the model hierarchy computations (processed image data sets).
  • pathological and anatomical models derived for characteristics of diseases include: pathological and anatomical models derived for characteristics of diseases, images representative of the diseases, and results of the model hierarchy computations (processed image data sets).
  • the capability of storing/retrieving information for a particular diseased tissue type enables broader access to the information, such as via the Internet, a hospital information system, a radiological information system, or other information transmission infrastructure. Additionally, this information allows matching and retrieval of exams classified as similar based on the information provided by model hierarchy computations.
  • processor 120 is adapted to automatically send detailed exam information to remote workstations or portable computing device via an information transmission infrastructure. In a further embodiment of processor 120, processor 120 is adapted to automatically send detailed exam information which meets selected specified requirements determined in advance of transmission or determined adaptively by the processing system. In order to further tune or adjust analysis programs, processor 120 is also adapted to tune at least one computer analysis algorithm based on information from model hierarchy computations stored in previous exams.
  • processor 120 is further adapted to generate statistical measurements based on the information from model hierarchy computations stored in previous exams and report results of the statistical measurements to a local or remote monitoring facility.
  • processor 120 may also be configured to report the results of the statistical measurements if predetermined criteria based on the system performance are met.
  • the steps outlined in the last section are implemented in C++ code based on the TargetJr image understanding library (http://www.targetjr.org).
  • a set of DICOM (Digital Image and Communication in Medicine) image files, one for each slice in the CT scan, are input into the program and the program returns suspicious nodules to be visualized on the original CT data or saved for further follow-up.
  • DICOM Digital Image and Communication in Medicine
  • the embodiments of the invention presented in previous paragraphs focus on the problem of locating suspicious regions in CT lung scans. It is to be appreciated that the hierarchical image modeling framework can be directly transferred to other imaging modalities (for example MRI, X-ray, ultrasound scanner, positron emission tomography (PET) scanner) and diseases by re-specifying the low-level detection techniques and the statistical distributions of anatomy.
  • imaging modalities for example MRI, X-ray, ultrasound scanner, positron emission tomography (PET) scanner
  • PET positron emission tomography

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EP02257868A 2001-11-20 2002-11-14 Procédé de traitement d'image et système pour détecter des maladies Expired - Fee Related EP1315125B1 (fr)

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US683111 2001-11-20
US09/683,111 US7058210B2 (en) 2001-11-20 2001-11-20 Method and system for lung disease detection

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EP1315125B1 (fr) 2008-06-04
EP1315125A3 (fr) 2003-07-09
US7058210B2 (en) 2006-06-06

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