EP1313512A4 - Facteur 2 de croissance endoth liale (vegf-2) - Google Patents
Facteur 2 de croissance endoth liale (vegf-2)Info
- Publication number
- EP1313512A4 EP1313512A4 EP01963814A EP01963814A EP1313512A4 EP 1313512 A4 EP1313512 A4 EP 1313512A4 EP 01963814 A EP01963814 A EP 01963814A EP 01963814 A EP01963814 A EP 01963814A EP 1313512 A4 EP1313512 A4 EP 1313512A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- growth factor
- vascular endothelial
- endothelial growth
- vascular
- factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 title 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 title 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Plant Pathology (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22327600P | 2000-08-04 | 2000-08-04 | |
US223276P | 2000-08-04 | ||
PCT/US2001/024658 WO2002011769A1 (fr) | 2000-08-04 | 2001-08-03 | Facteur 2 de croissance endothéliale (vegf-2) |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1313512A1 EP1313512A1 (fr) | 2003-05-28 |
EP1313512A4 true EP1313512A4 (fr) | 2004-08-25 |
Family
ID=22835805
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP01963814A Withdrawn EP1313512A4 (fr) | 2000-08-04 | 2001-08-03 | Facteur 2 de croissance endoth liale (vegf-2) |
Country Status (10)
Country | Link |
---|---|
US (2) | US7273751B2 (fr) |
EP (1) | EP1313512A4 (fr) |
JP (1) | JP2004505619A (fr) |
KR (1) | KR20020059609A (fr) |
CN (1) | CN1211126C (fr) |
AU (1) | AU8473401A (fr) |
CA (1) | CA2386103A1 (fr) |
MX (1) | MXPA02003434A (fr) |
NZ (1) | NZ518077A (fr) |
WO (1) | WO2002011769A1 (fr) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6824777B1 (en) | 1992-10-09 | 2004-11-30 | Licentia Ltd. | Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy |
US7109308B1 (en) | 1994-03-08 | 2006-09-19 | Human Genome Sciences, Inc. | Antibodies to human vascular endothelial growth factor 2 |
US5932540A (en) | 1994-03-08 | 1999-08-03 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
US7186688B1 (en) | 1994-03-08 | 2007-03-06 | Human Genome Sciences, Inc. | Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2 |
US6608182B1 (en) | 1994-03-08 | 2003-08-19 | Human Genome Sciences, Inc. | Human vascular endothelial growth factor 2 |
US7153827B1 (en) | 1994-03-08 | 2006-12-26 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 and methods of use |
US6040157A (en) | 1994-03-08 | 2000-03-21 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
CN1267550C (zh) | 1994-03-08 | 2006-08-02 | 人体基因组科学有限公司 | 血管内皮生长因子2 |
WO2002060950A2 (fr) * | 1994-11-14 | 2002-08-08 | Ludwig Institute For Cancer Research | Flt4 (vegfr-3) utilise comme cible pour l'imagerie des tumeurs et le traitement antitumoral |
US7125714B2 (en) | 1997-02-05 | 2006-10-24 | Licentia Ltd. | Progenitor cell materials and methods |
US20040228834A1 (en) * | 1998-03-09 | 2004-11-18 | Jeffrey Isner | Compositions and methods for modulating vascularization |
US7223724B1 (en) * | 1999-02-08 | 2007-05-29 | Human Genome Sciences, Inc. | Use of vascular endothelial growth factor to treat photoreceptor cells |
KR20020059609A (ko) * | 2000-08-04 | 2002-07-13 | 벤슨 로버트 에이치. | 혈관 내피 성장 인자 2 |
US7611711B2 (en) * | 2001-01-17 | 2009-11-03 | Vegenics Limited | VEGFR-3 inhibitor materials and methods |
DE60236646D1 (de) | 2001-04-13 | 2010-07-22 | Human Genome Sciences Inc | Anti-VEGF-2 Antikörper |
AU2002252631A1 (en) * | 2001-04-13 | 2002-10-28 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
US20050232921A1 (en) * | 2001-04-13 | 2005-10-20 | Rosen Craig A | Vascular endothelial growth factor 2 |
EP1425580A4 (fr) * | 2001-07-12 | 2006-03-29 | Ludwig Inst Cancer Res | Cellules endotheliales lymphatiques et procedes correspondants |
US20030113324A1 (en) * | 2001-10-01 | 2003-06-19 | Kari Alitalo | Neuropilin/VEGF-C/VEGFR-3 materials and methods |
US20040214766A1 (en) * | 2001-10-01 | 2004-10-28 | Kari Alitalo | VEGF-C or VEGF-D materials and methods for treatment of neuropathologies |
WO2004070018A2 (fr) * | 2003-02-04 | 2004-08-19 | Ludwig Institute For Cancer Research | Modulation vegf-b et pdgf de cellules souches |
WO2005016963A2 (fr) * | 2003-06-12 | 2005-02-24 | Ludwig Institute For Cancer Research | Ligands de recepteur 3 du facteur de croissance des cellules endotheliales de liaison a l'heparine |
EP1635860A2 (fr) * | 2003-06-12 | 2006-03-22 | Ludwig Institute For Cancer Research | Utilisation de vegf-c ou de vegf-d en chirurgie reconstructive |
CN100448892C (zh) * | 2006-08-02 | 2009-01-07 | 中国人民解放军军事医学科学院基础医学研究所 | 抗肿瘤血管内皮生长因子受体vegf-r2抗原及其编码基因与应用 |
US20120141424A1 (en) * | 2009-01-07 | 2012-06-07 | Vegenics Pty Limited | Materials and Methods for the Treatment of Hypertension |
AU2010286511B2 (en) | 2009-08-28 | 2016-05-26 | Juventas Therapeutics, Inc. | SDF-1 delivery for treating ischemic tissue |
WO2011079222A2 (fr) | 2009-12-23 | 2011-06-30 | Boston Scientific Scimed, Inc. | Méthode moins traumatique de pose de dispositifs à maillage dans le corps humain |
WO2014124487A1 (fr) | 2013-02-18 | 2014-08-21 | Vegenics Pty Limited | Molécules de liaison à des ligands et utilisations de celles-ci |
US20200113972A1 (en) * | 2017-04-14 | 2020-04-16 | Rhode Island Hospital | Vegf gene therapy for tendon and ligament injuries |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999046364A1 (fr) * | 1998-03-13 | 1999-09-16 | Human Genome Sciences, Inc. | Facteur de croissance endothelial vasculaire 2 |
Family Cites Families (95)
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EP0186084B1 (fr) | 1984-12-24 | 1991-09-04 | Merck & Co. Inc. | Facteur de croissance dérivé du cerveau |
US5073492A (en) | 1987-01-09 | 1991-12-17 | The Johns Hopkins University | Synergistic composition for endothelial cell growth |
JPS6438100U (fr) | 1987-08-26 | 1989-03-07 | ||
JPH02117698A (ja) | 1988-10-27 | 1990-05-02 | Toray Ind Inc | 血管内皮細胞成長因子 |
US5240848A (en) | 1988-11-21 | 1993-08-31 | Monsanto Company | Dna sequences encoding human vascular permeability factor having 189 amino acids |
US5693622A (en) | 1989-03-21 | 1997-12-02 | Vical Incorporated | Expression of exogenous polynucleotide sequences cardiac muscle of a mammal |
CA2017379C (fr) | 1989-05-24 | 2002-06-25 | Kenneth A. Thomas, Jr. | Purification et caracterisation d'un facteur de croissance derive de gliomes |
US5219739A (en) | 1989-07-27 | 1993-06-15 | Scios Nova Inc. | DNA sequences encoding bVEGF120 and hVEGF121 and methods for the production of bovine and human vascular endothelial cell growth factors, bVEGF120 and hVEGF121 |
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DE69132040T2 (de) | 1990-09-21 | 2000-11-02 | Merck & Co Inc | Wachstumsfaktor II für vaskuläre Endothelzellen |
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CA2064331C (fr) | 1991-03-28 | 2003-02-18 | Marvin L. Bayne | Sous-unite c du facteur de croissance des cellules endotheliales des vaisseaux |
US5185438A (en) | 1991-04-02 | 1993-02-09 | The Trustees Of Princeton University | Nucleic acids encoding hencatoporetic stem cell receptor flk-2 |
US5234908A (en) | 1991-04-12 | 1993-08-10 | Creative Biomolecules, Inc. | Method of treating gastrointestinal ulcers with platelet derived growth factor |
US5661133B1 (en) | 1991-11-12 | 1999-06-01 | Univ Michigan | Collateral blood vessel formation in cardiac muscle by injecting a dna sequence encoding an angiogenic protein |
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CN1267550C (zh) * | 1994-03-08 | 2006-08-02 | 人体基因组科学有限公司 | 血管内皮生长因子2 |
US6734285B2 (en) * | 1994-03-08 | 2004-05-11 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 proteins and compositions |
US5633147A (en) | 1994-03-08 | 1997-05-27 | Human Genome Sciences, Inc. | Transforming growth factor αH1 |
US7153827B1 (en) * | 1994-03-08 | 2006-12-26 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 and methods of use |
US7186688B1 (en) * | 1994-03-08 | 2007-03-06 | Human Genome Sciences, Inc. | Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2 |
US6040157A (en) | 1994-03-08 | 2000-03-21 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
US5817485A (en) | 1994-03-08 | 1998-10-06 | Human Genome Sciences, Inc. | Nucleic acids and cells for recombinant production of fibroblast growth factor-10 |
US7109308B1 (en) * | 1994-03-08 | 2006-09-19 | Human Genome Sciences, Inc. | Antibodies to human vascular endothelial growth factor 2 |
US6608182B1 (en) | 1994-03-08 | 2003-08-19 | Human Genome Sciences, Inc. | Human vascular endothelial growth factor 2 |
US5932540A (en) * | 1994-03-08 | 1999-08-03 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
ATE262345T1 (de) | 1994-08-23 | 2004-04-15 | Human Genome Sciences Inc | Menschliche chemokin-polypeptide |
US5652225A (en) | 1994-10-04 | 1997-07-29 | St. Elizabeth's Medical Center Of Boston, Inc. | Methods and products for nucleic acid delivery |
US6645933B1 (en) | 1995-08-01 | 2003-11-11 | Helsinki University Licensing Ltd. Oy | Receptor ligand VEGF-C |
WO1998033917A1 (fr) | 1994-11-14 | 1998-08-06 | The Ludwig Institute For Cancer Research | Proteine et gene du facteur de croissance vasculaire endothelial c (vegf-c), mutants de ce dernier et utilisations |
US6130071A (en) | 1997-02-05 | 2000-10-10 | Helsinki University Licensing, Ltd. | Vascular endothelial growth factor C (VEGF-C) ΔCys156 protein and gene, and uses thereof |
US6403088B1 (en) | 1995-08-01 | 2002-06-11 | Helsinki University Licensing, Ltd. | Antibodies reactive with VEGF-C, a ligand for the Flt4 receptor tyrosine kinase (VEGFR-3) |
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US6221839B1 (en) | 1994-11-14 | 2001-04-24 | Helsinki University Licensing Ltd. Oy | FIt4 ligand and methods of use |
US5792453A (en) | 1995-02-28 | 1998-08-11 | The Regents Of The University Of California | Gene transfer-mediated angiogenesis therapy |
US5928939A (en) | 1995-03-01 | 1999-07-27 | Ludwig Institute For Cancer Research | Vascular endothelial growth factor-b and dna coding therefor |
US5607918A (en) | 1995-03-01 | 1997-03-04 | Ludwig Institute For Cancer Research | Vascular endothelial growth factor-B and DNA coding therefor |
EP2258726A1 (fr) | 1995-06-14 | 2010-12-08 | The Regents of the University of California | Anticorps humains à haute affinité pour c-erbB-2 |
US6361946B1 (en) | 1997-02-05 | 2002-03-26 | Licentia Ltd | Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof |
EP0848755B2 (fr) | 1995-09-08 | 2011-02-09 | Genentech, Inc. | Proteine apparentee au vegf |
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WO1997017442A1 (fr) | 1995-11-08 | 1997-05-15 | Immunex Corporation | Proteine de liaison flk-1 |
US5641750A (en) | 1995-11-29 | 1997-06-24 | Amgen Inc. | Methods for treating photoreceptors using glial cell line-derived neurotrophic factor (GDNF) protein product |
PT950100E (pt) | 1996-08-13 | 2004-06-30 | Human Genome Sciences Inc | Mutantes do factor 2 de crescimento dos ceranocitos (fcc-2 ou factor 12 de crescimento dos fibroblastos fcf-12) |
EP1749836B1 (fr) | 1996-08-23 | 2009-06-17 | Vegenics Limited | Facteur D recombinant de croissance de cellules vasculaires endothéliales |
WO1998024811A2 (fr) | 1996-12-06 | 1998-06-11 | Zymogenetics, Inc. | Facteur de croissance endotheliale vasculaire |
JP2001509168A (ja) | 1997-01-29 | 2001-07-10 | コーネル リサーチ ファウンデーション、インコーポレイティッド | 血管新生を誘導するためのアデノウイルスベクターの多部位送達 |
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WO1998049300A2 (fr) | 1997-04-25 | 1998-11-05 | Collateral Therapeutics | Formes tronquees de proteines apparentees au facteur vegf |
EP0990034A1 (fr) | 1997-06-06 | 2000-04-05 | Asat AG Applied Science & Technology | Anticorps recombines anti-gpiib/iiia |
EP0990042A1 (fr) | 1997-06-10 | 2000-04-05 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Sequences regulatrices impliquees dans l'expression genique regulee par l'hypoxie et leurs utilisations |
NZ501990A (en) | 1997-07-08 | 2002-09-27 | Viventia Biotech Inc | Compositions containing antigen-binding fragments that recognise the antigen recognised by a recombinant 4B5 antibody |
JP2001514867A (ja) | 1997-08-15 | 2001-09-18 | ルードヴィッヒ・インスティテュート・フォア・キャンサー・リサーチ | 内皮のタンパク分解活性および/または血管形成活性の刺激、調節および/または阻害 |
GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
EP1027075A1 (fr) | 1997-10-27 | 2000-08-16 | Merck & Co., Inc. | Therapie genique pour la stimulation de l'angiogenese |
US6713474B2 (en) | 1998-09-18 | 2004-03-30 | Abbott Gmbh & Co. Kg | Pyrrolopyrimidines as therapeutic agents |
NZ511408A (en) | 1998-10-09 | 2004-04-30 | Licentia Ltd | Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy |
CA2346798A1 (fr) | 1998-10-19 | 2000-04-27 | Ludwig Institute For Cancer Research | Nouvelle liaison neuropiline/facteur de croissance et applications de celle-ci |
CN1338943A (zh) | 1998-10-26 | 2002-03-06 | 路德维格癌症研究院 | 利用vegf-c或vegf-d基因或蛋白预防再狭窄 |
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- 2001-08-03 CN CNB01803019XA patent/CN1211126C/zh not_active Expired - Fee Related
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Also Published As
Publication number | Publication date |
---|---|
CN1416354A (zh) | 2003-05-07 |
US7273751B2 (en) | 2007-09-25 |
CN1211126C (zh) | 2005-07-20 |
KR20020059609A (ko) | 2002-07-13 |
AU8473401A (en) | 2002-02-18 |
MXPA02003434A (es) | 2002-09-02 |
EP1313512A1 (fr) | 2003-05-28 |
JP2004505619A (ja) | 2004-02-26 |
WO2002011769A1 (fr) | 2002-02-14 |
US20030215921A1 (en) | 2003-11-20 |
US20060057117A1 (en) | 2006-03-16 |
NZ518077A (en) | 2003-11-28 |
CA2386103A1 (fr) | 2002-02-14 |
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