Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M15/00—Inhalators
  • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B32—LAYERED PRODUCTS
  • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
  • B32B3/00—Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shape; Layered products comprising a layer having particular features of form
  • B32B3/10—Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shape; Layered products comprising a layer having particular features of form characterised by a discontinuous layer, i.e. formed of separate pieces of material
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
  • A61K9/7007—Drug-containing films, membranes or sheets
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M15/00—Inhalators
  • A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
  • B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
  • B05C13/00—Means for manipulating or holding work, e.g. for separate articles

Definitions

• the present invention relates to substrates used as the support on which powders are deposited using techniques wherein electrical forces attract the powders for localized deposition.
• electrostatic chuck that provides the electrical forces (e.g., electrostatic) that attracts the particles or grains.
• the particles or grains are typically charged, though attraction can occur through induced polarizations of the particles or grains.
• the electrostatic chuck has, for example, electrode pads to which electrical potentials are applied to create attractive forces. Adjacent electrodes, of a different potential, can be used to shape the attractive forces or steer particles or grains away from undesired locations.
• a limitation on this technology has been the amount of particles or grains that can be effectively directed to a given location.
• One source of this limitation is a practical limit to the strength and localization of the electrical forces close to a given deposition location.
• the present invention addresses this problem by creating substrates for the deposition having patterned inlays of conductive material, which conductive inlay material serves as an extension or adjunct to the electrode pads of the electrostatic chuck, allowing greater charge density near the site of deposition.
• the invention provides improved quality of the depositions and allows larger quantities to be deposited.
• the invention provides, for example, a conductive inlay film comprising: a layer of dielectric film having a pattern of holes suitable to define selected regions to which particles will be deposited by electrostatic deposition; and a conductive element comprising polymer, which element comprises (a) a conductive film laminated against the dielectric film or (b) a conductive film embedded within the holes, the portion of the conductive element appearing within the holes comprising conductive inlays, wherein the conductive element is adapted to contact one or more electrode pads and provide electrical potentials at the selected regions, and wherein the dielectric film electrically isolates the selected regions.
• the invention can be used to deposit measured amounts of particles on the selected regions of substrates, wherein the amounts of particles deposited on the selected regions can be measured amounts.
• the measured amounts can be of a medicament, forming a dosage unit.
• the conductive inlay film can comprise a diagnostic product with measured amounts of diagnostic reagent at two or more selected regions.
• the invention also provides a method of electro-attractive deposition onto a substrate comprising: layering a conductive inlay film onto a surface of an electrostatic chuck comprising at least one electrode contacting the surface, wherein the conductive inlay film comprises conductive polymer effective to transmit potentials from the electrodes to the vicinity of selected regions of the conductive inlay film and dielectric film effective to electrically isolate the selected regions; applying a potential to the at least one electrode; directing particles toward the conductive inlay film; and selectively depositing particles at the selected regions.
• electrostatic chuck indicates its use to attract charged powder/particles; such a chuck need not necessarily electrically adhere the substrate to which the powder/particles will be applied.
• the substrate can be layered on the chuck with, for example, vacuum or adhesive.
• a pharmaceutical, vitamin formulation, sweetener formulation, herbal formulation, veterinary formulation, or diagnostic product comprising: at least a portion of a conductive inlay film, the conductive inlay film comprising: a layer of dielectric film having a pattern of holes suitable to define selected regions to which particles will be deposited by electrostatic deposition; and a conductive element comprising polymer, which element comprises (a) a conductive film laminated against the dielectric film or (b) a conductive film embedded within the holes, the portion of the conductive element appearing within the holes comprising conductive inlays), the portion comprising a said inlay surrounded by the dielectric film; and a defined amount of pharmaceutical, vitamin, sweetener, herbal product, veterinary pharmaceutical or diagnostic agent selectively deposited on one or more said inlays.
• Figures 1A and IB display a conductive inlay film according to the invention.
• Figures 2A and 2B show another a conductive inlay film according to the invention.
• Figure 3 shows an exemplary electrostatic chuck.
• Figure 1A shows a cross-section of conductive inlay film 20 having conductive film 22 laminated to dielectric film 21.
• the dielectric film 21 is of a relatively low conductivity and thickness as to allow selective attraction of charged particles to selected regions 23, while limiting any attraction of the particles to areas outside the selected region 23.
• Suitable dielectric films include, for example, films of ethylcellulose, cellulose acetate phthalate, hydroxypropylmethyl cellulose (HPMC), hydroxypropylmethyl cellulose phthalate, hydroxypropyl cellulose (HPC), methyl cellulose, modified starch, protein (including, e.g.
• crosslinked gelatin alginic acid
• acrylic polymer e.g., methyl methacrylate, ethyl acrylate, copolymers of methyl methacrylate, and ethyl acrylate, and the like, such as EudragitTM acrylic copolymers
• polyalkylene oxide such as polyethylene oxide
• PNP polyvinylpyrrolidone
• Crosslinked PNP polylactide
• poly(lactide-co-glycolide non-woven fabric, paper, and the like.
• Film forming processes include casting of polymer solutions or dispersions and extrusion molding of polymer powders.
• the conductive film is preferably formed of materials that are appropriate for human consumption. For certain materials, this preferred restriction means appropriate in the amount and dosing of the consumable product.
• the conductive film is formed of a polymer which is itself conductive, or which provides a structural framework for a conductive material incorporated into the film.
• the conductive material can be, for example, a metallic weave, metal particles (such as particles of gold, silver or iron), carbon black particles, particles of other ionic species, and the like.
• the conductive material can also be a conductive polymer, such as gelatin or other proteinaceous material.
• Suitable polymers for imbedding conductive material include ethylcellulose, cellulose acetate phthalate, HPMC, hydroxypropylmethyl cellulose phthalate, HPC, methyl cellulose, modified starch, protein (including, e.g.
• crosslinked gelatin alginic acid
• acrylic polymer e.g., methyl methacrylate, ethyl acrylate, copolymers of methyl methacrylate, and ethyl acrylate, and the like, such as EudragitTM acrylic copolymers
• polyalkylene oxide such as polyethylene oxide
• polyvinyl alcohol PNP, crosslinked PNP, polylactide, poly(lactide-co-glycolide), non- woven fabric, paper, and the like.
• the water soluble polymer examples can be cast from a water solution, with the casting and drying conducted at a temperature above the lower critical solution temperature ("LCST").
• the LCST for HPC for example, is typically in the 50-55°C range.
• Film forming processes again can include casting of polymer solutions or dispersions and extrusion molding of polymer powders.
• the conductive elements of the conductive inlay film e.g., conductive film 22 or conductive inlay 32 (see below), have a resistivity of 10 5 ohm/square or less, more preferably 10 4 or 10 3 ohm/square or less.
• the selected regions 23 can be formed, for example, by cutting the dielectric film prior to laminating the film to the conductive film.
• the sizes of the selected regions 23 are, in pharmaceutical applications especially, for example from 1 mm to 10 mm in width or diameter.
• the conductive inlay film of the invention is preferably flexible.
• the elements of the conductive inlay film on which particles are deposited are favorably water-swellable or dispersible, facilitating the dispersal or dissolution of deposited particles (see definition below) in appropriate aqueous solutions (e.g., acidic, basic or neutral, depending on the intended use of the conductive inlay film with deposited particles).
• Suitable thicknesses for the conductive inlay film include from 0.5 mil to 10 mil, more preferably 1.0 mil to 5 mil.
• Figure 2 A shows a cross-section of conductive inlay film 30 having conductive inlays 32 in dielectric film 31.
• the dielectric film 31 is of a relatively low conductivity and thickness as to allow selective attraction of charged particles to selected regions 33, while limiting any attraction of the particles to areas outside the selected region 33.
• This embodiment can be designed so that the conductive inlays 32 align with conductive pads on the surface of an electrostatic chuck. Again, the dielectric film is selected to maintain the electrical isolation of the selected regions such that particle-attracting fields are confined to these regions.
• the embodiment of Figure 2 can be formed, for example, by layering the dielectric film, on which holes corresponding to the selected regions have been formed, onto a release layer.
• a polymer solution or water-swellable gel which can have conductive particles suspended therein, is used to fill the holes.
• Water-swellable gels- forming polymers include ethylcellulose, cellulose acetate phthalate, HPMC, hydroxypropylmethyl cellulose phthalate, HPC, methyl cellulose, modified starch, protein (including, e.g.
• the conductive inlay films of the invention can be used in methods of electrostatically depositing particles thereon.
• Deposition measurements can include optical measurement following deposition, and the use of electrical sensors that dynamically monitor deposition.
• One useful method of charging the particles is induction charging by passing the particles through a jet mill with conductive walls to which a potential is applied.
• Figure 3 shows a cross-section of a coplanar chuck 10 where deposition electrodes 14 are separated from shield electrodes 13 by dielectric (preferably atmosphere) 15, with these features seated in base material 12.
• the deposition electrodes 14 are preferably formed of series 300 stainless steel.
• Deposition electrodes 14 contain a pin receptacle 16 for connection to circuit board 11.
• Base material 12 is made of a dielectric such as Noryl® polymer (GE Plastics, Pittsfield, MA).
• Noryl engineered plastics are modified polyphenylene oxide, or polyphenylene oxide and polyphenylene ether, resins. The modification of these resins involves blending with a second polymer such as polystyrene or polystyrene/butadiene.
• the shield electrodes 13 can be made from a conductive material (such as 300 series stainless steel) adhered to the base material 12, for example by an adhesive or a double-sided, rubber-based adhesive tape.
• the annular gaps that are the preferred embodiment of dielectric 15 can be made by drilling a series of holes in the conductor layer that will form the shield electrodes 13.
• the deposition electrodes 14 can be, for example, pressed or glued into the base material.
• the assembly is preferably ground to create a flat, coplanar surface, for example within a tolerance of 0.0002 inches.
• dielectric 15 is atmosphere (that atmosphere in which the electrostatic chuck operates)
• the portion of the dielectric separation of the electrodes comprising atmosphere is sufficient so that in use the upper plane of the electrostatic chuck aligned with dielectric 15 discharges completely between depositions. Such an amount of dielectric separation is "substantial" separation.
• Such an electrostatic chuck can be simply modified with the techniques described to incorporate electrically isolated shield electrodes that can be separately connected to control electronics to provide the sensing circuits described above.
• Dimension A can be, for example, 0.01 inch;
• Dimension B can be, for example, 0.157 inch;
• Dimension C can be, for example, 0.236 inch;
• Dimension D the pitch between pixels, can be, for example, 0.3543 inch.
• the electrostatic chuck can be operated, for example, with a voltage of -700 or -1,400 V applied to the deposition electrodes.
• the measured amounts of particles or grains deposited by the invention can be useful in a number of contexts, such as pharmaceuticals, vitamin formulations, sweetener formulations, herbal formulations, veterinary formulations, diagnostic products (with defined quantities of control substances or diagnostic reagents), and the like.
• Particles for deposition are, for the purposes of this application, aggregates of molecules, typically of at least about 3 nm average diameter, such at least about 500 nm or 800 nm average diameter, and are preferably from about 100 nm to about 5 mm, for example, about 100 nm to about 500 ⁇ m. Particles are, for example, particles of a micronized powder, or polymer structure that can be referred to as "beads.” Beads can be coated, have adsorbed molecules, have entrapped molecules, or otherwise carry other substances.
• Electro-attractive dry deposition refers to methods that use electrical forces to attract or deposit charged particles to a surface.
• Dosage unit refers to a convenient amount of a given substance.
• the term typically refers to amounts that add up to, using a convenient number of dosage units, an appropriate dosage of a pharmaceutical.
• the invention described herein can be used in conjunction with a number of devices and methods described by applicants or those working with applicants.
• the "Device for the Dispersal and Charging of Fluidized Powder” application of Sun et al., Serial No. 09/417,820, October 14, 1999 can be used in conjunction with the invention.
• Example 1 Two-layer Polymer Film of Ethylcellulose CEO and HPMC:
• the two-layer polymer film consists of a hydrophobic ethylcellulose (EC) film layer and a hydrophilic HPMC film layer.
• the first step Cast EC dispersion plasticized with triacetin or other plasticizers over a Mylar film to make the ethylcellulose (EC) layer. Drying is conducted in a temperature/humidity-controlled chamber at 55°C and 35%RH.
• the second step Cast HPMC solution over the resulting EC film, making the hydrophilic layer. Drying is conducted at 28°C and 45%RH. The two-layer film is then peeled off from the Mylar film.
• Example 2 Polymer film Attached with Conductive Domains
• the EC film has high surface resistivity (targeted at 2.6E+12 ohm/square at 20 %RH and 1.2E+12 ohm/square at 30%RH, respectively).

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• Health & Medical Sciences (AREA)
• Engineering & Computer Science (AREA)
• Bioinformatics & Cheminformatics (AREA)
• Animal Behavior & Ethology (AREA)
• Veterinary Medicine (AREA)
• Public Health (AREA)
• General Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Pharmacology & Pharmacy (AREA)
• Epidemiology (AREA)
• Medicinal Chemistry (AREA)
• Chemical & Material Sciences (AREA)
• Pulmonology (AREA)
• Anesthesiology (AREA)
• Biomedical Technology (AREA)
• Heart & Thoracic Surgery (AREA)
• Hematology (AREA)
• Medicinal Preparation (AREA)
• Conductive Materials (AREA)
• Laminated Bodies (AREA)

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• 2001
  • 2001-07-11 JP JP2002508890A patent/JP2004502512A/ja active Pending
  • 2001-07-11 EP EP01955063A patent/EP1299230A1/en not_active Withdrawn
  • 2001-07-11 AU AU2001277268A patent/AU2001277268A1/en not_active Abandoned
  • 2001-07-11 WO PCT/US2001/041339 patent/WO2002004202A1/en not_active Application Discontinuation
  • 2001-07-11 IL IL15386801A patent/IL153868A0/xx unknown
  • 2001-07-11 KR KR10-2003-7000422A patent/KR20030015382A/ko not_active Application Discontinuation
  • 2001-07-11 HU HU0301611A patent/HUP0301611A2/hu unknown
  • 2001-07-11 CN CN01812343A patent/CN1440329A/zh active Pending
  • 2001-07-11 CA CA002413549A patent/CA2413549A1/en not_active Abandoned

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