EP1289491A1 - Composition cosm tique et/ou dermatologique base d'extraits de cacao - Google Patents
Composition cosm tique et/ou dermatologique base d'extraits de cacaoInfo
- Publication number
- EP1289491A1 EP1289491A1 EP01947503A EP01947503A EP1289491A1 EP 1289491 A1 EP1289491 A1 EP 1289491A1 EP 01947503 A EP01947503 A EP 01947503A EP 01947503 A EP01947503 A EP 01947503A EP 1289491 A1 EP1289491 A1 EP 1289491A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- cocoa
- cosmetic
- polyphenols
- composition
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Definitions
- the present invention relates to a new cosmetic and / or dermatological composition, and more particularly a composition based on cocoa extracts (Theobroma cacao) having excellent properties usable in cosmetics and in dermatology for the care and protection of the skin.
- the skin comprises superficial layers, namely the epidemic, and deeper layers, the dermis and the hypodermis, and each has specific properties allowing the whole to react and adapt to the conditions of its environment.
- the epidermis which constitutes the outer layer, plays a fundamental role in ensuring the protection and maintenance of good trophicity. This is why many compositions have been developed in order to protect it and improve its functions.
- These cosmetic and dermatological compositions intended for the treatment of skin conditions by topical application must comply with certain conditions in order to be well accepted by the users. More particularly, they must have good physical properties, in particular consistency and smoothness, have satisfactory effectiveness, and be pleasant to use. In addition, they must be able to be stored under normal conditions of temperature and humidity without significantly degrading and retaining their properties for extended periods.
- compositions In addition to these physical properties, the compositions must have a set of activities which can be used cosmetically and pharmaceutically. In particular, compositions are generally sought which combine properties of hydration and protection of the skin against attack. of the environment where aging takes place manifested by the formation of wrinkles and spots, greater dryness and loss of elasticity of the skin
- Free radicals are known for their accelerating effect on cell aging. Their formation is often favored by external factors such as ultraviolet rays, pollution and the action of certain drugs. Protection systems of the body against free radicals tend to lose their effectiveness with age and it is therefore desirable to be able to have substances capable of neutralizing the harmful effects of free radicals.
- Various polyphenols are often used for this purpose.
- FR-A- 2749303 discloses a method of catechin polyphenols extraction from plants by means of an organic solvent and their use in cosmetic compositions having properties antiradic 'alar useful against aging the skin.
- Cocoa is known to have stimulating, tonic, nutritious and anti-stress effects, and various substances have been extracted from cocoa due to such properties.
- cocoa butter is used in many food, cosmetic and pharmaceutical compositions.
- the cocoa tree (Theobroma cacao) is a shrub native to the forests of Central America and the equatorial forests of South America.
- Various substances have been extracted from beans or cockles.
- a process for treating cocoa beans to obtain food and diet products containing polyphenols is described in US-A-6,015,913.
- Patent JP-A-00.128801 describes an antibacterial composition comprising an extract of mint and an extract of tea leaves or cocoa beans containing polyphenols, which can be used in food products and beverages.
- Patent FR-A-2,413,042 describes a process for extracting cocoa shells using an acidic solution of an alcohol, and the use of the product as well obtained in food compositions. On the other hand, it has not yet been envisaged to use a total cocoa extract in cosmetic or dermatological compositions.
- the present invention. ' relates to a new composition which can be used in cosmetics and / or in dermatology, obtained by cocoa extraction, and containing polyphenols.
- a subject of the invention is also a cosmetic and / or dermatological composition based on cocoa protein extract.
- Theobroma cocoa comprising at least polyphenols, amino acids and an unsaponifiable fraction.
- the invention also relates to the use of a composition as indicated above for the treatment and prevention of the signs of skin aging such as the appearance of wrinkles and the loss of elasticity of the skin.
- the present invention also relates to a method of cosmetic treatment of the skin consisting in applying to the skin a composition as indicated above.
- the composition according to the present invention essentially comprises a cocoa extract containing polyphenols. More particularly, the composition of the invention comprises a cocoa extract containing in combination polyphenols, and amino acids and / or a concentrate of unsaponifiables.
- the composition contains in combination - from 0.05 to 5% by weight of amino acids extracted from cocoa; from 0.05 to 5% by weight of polyphenols extracted from cocoa; from 0.05 to 3% by weight of concentrate of unsaponifiables.
- the extraction method used in the invention consists in carrying out an extraction of a known type, for example by grinding cocoa beans and hydrophilic / lipophilic separation of cocoa butter on the one hand and a mixture of proteins and polyphenols on the other hand.
- the hydrophilic / lipophilic separation makes it possible, by extraction of the ground seed, to separate the supernatants of the poly- ' phase with water .
- phenols / proteins preferably brought to a temperature of between 80 and 100 ° C. is preferably used.
- Proteins are separated for example by tangential ultrafiltration (proteins> 10,000 Da) while the polyphenols are dried and then encapsulated if necessary.
- the fraction enriched in unsaponifiables is obtained from cocoa butter by molecular distillation at 200-300 ° C under vacuum (about 10 ⁇ 4 to 10 ⁇ 2 mm Hg / 0.13 to 13 Pa).
- the polyphenolic extract thus obtained is in the form of a dark colored liquid soluble in water and alcohols.
- the extraction is preferably carried out from cocoa beans (Theobroma cacao). It is thus possible to obtain extracts with a high protein content (greater than 5%) having excellent properties.
- the aminogram of the protein extract highlighted the following main amino acids. In the following table, the amino acid contents are indicated in grams per 100 g of extract. Wisteria 26.3
- the analysis also shows the presence, in a content of less than 1% by weight, of proline, cystine, methionine and histidine.
- the polyphenolic cocoa extract used in the present invention is in the form of an amber colored liquid, soluble in water and in alcohols, having excellent anti-free radical properties giving the compositions according to the invention good efficacy in prevention of skin aging and reduction of wrinkles.
- the polyphenols extracted from cocoa used in the invention are preferably encapsulated, for example in the form of lecithin-based liposomes, the average size of which is preferably close to 100 ⁇ m, in order to protect them and avoid their polymerization.
- the extract according to the invention also contains a concentrate of unsaponifiables which can be separated from the total extract by extraction with carbon dioxide, or, preferably, by molecular distillation.
- This concentrate of unsaponifiables contains hydrocarbons, tocopherol, terpene alcohols and sterols, and it has fibroblast-stimulating properties which are particularly advantageous for the dermatological compositions of the invention.
- the composition according to the present invention may advantageously contain a hydrogenated lecithin.
- the hydrogenated lecithin used in the invention is preferably a hydrogenated soy lecithin or a hydrogenated sunflower lecithin.
- Commercially available lecithins generally contain pure lecithin (phosphatidyl choline) in admixture with other phosphoglycerides such as cephalin (in particular phosphatidyl ethanolamine) and phosphatidyl inositol.
- cephalin in particular phosphatidyl ethanolamine
- phosphatidyl inositol phosphatidyl inositol.
- An example of hydrogenated lecithin which can be used in the invention is that sold commercially. under the brand Emulmetik 320® by the company Lucas Mayer (hydrogenated soy lecithin).
- compositions may also advantageously contain cocoa oil and cocoa butter.
- topical administration means any method consisting in applying the substance or composition directly to the skin.
- the composition can be administered topically and it can advantageously contain, in addition to the basic components described above, one or more other substances known to exert complementary beneficial effects for the skin, and more particularly tocopherol. , vitamin A (retinol), retinoic acid, bactericidal agents, etc.
- the cosmetic or pharmaceutical compositions in accordance with the present invention are intended for topical administration, and contain carriers and excipients commonly used in compositions of this type, such as O / W or W / O emulsions, creams, gels. or lotions.
- the fatty phase can represent between 10 and 60% approximately of the weight of the composition, the aqueous phase between 10 and 80% approximately and the emulsifying agent between 2 and 20%, the rest being constituted by the components basic components listed above and the other components listed below.
- the composition may also contain various substances and excipients chosen as a function of their known properties and of the dosage form envisaged.
- preservatives, emulsifiers, viscosifiers, thickeners, gelling agents, antioxidants, hydrating agents, surfactants, perfumes, oils, lipids, a specific solvent can also be incorporated into the composition. as water and various additives intended to ' improve' the physical properties of the composition.
- filters or sunscreens chosen according to the degree of protection sought.
- the viscosifying agents used in the compositions of the invention may be selected from various acrylic acid polymers, cellulose gum, silica, carboxyvinyl polymers, e.g. Carbomer ®, aluminum and magnesium silicate, and colloidal silica for example can be used sold under the trademark Aerosil 200 ® or a crosslinked polyacrylic acid such as Carbopol 940 ®.
- the gelling agents or thickeners can be chosen, for example, from polyacrylamides, acrylates such as Pemulen®, cellulose derivatives such as hydroxypropyl cellulose, or natural gums.
- the hydrating agents used in the compositions of the invention may be chosen, for example, from a polyol, sorbitol, maltitol, pentaerythritol, glyceryl polyacrylates and polymethacrylates, glycerol or glycerol derivatives. It is also possible to add emollients such as an alkyl malate, isohexadecane, triglycerides of capric or caprylic acid, etc.
- preservatives of the technique of dermatological or cosmetic compositions can be used in the invention, and for example benzoic acid and an alkyl p-hydroxybenzoate such as- methyl and propyl p-hydroxy benzoates (methylparaben and Propylparaben), or imidazolidinyl urea.
- the constituents of the fatty phase can be chosen from jojoba oil, corn oil, petroleum jelly oil, hydrogenated coconut oil, safflower oil, glycerides of saturated fatty acids, stearic acid, palmitic acid, octyl stearate, glyceryl palmitate, octyl palmitate, a triglyceride of capric and caprylic acids, 2 -octyl- dodecanol, lanolin alcohol, polyethylene glycol, 2-ethylhexyl adipate, or alternatively silicone oils such as methyl phenyl polysiloxane, dimethicone, cyclomethicone, cyclomethicone / dimethicone copolyol, • phenyl trimethicone.
- the composition can also contain, in addition to water (preferably demineralized water), a specific solvent, such as an alcohol such as ethyl alcohol, or a diethylene glycol ether such as ethoxydiglycol or 1 ' diethylene glycol monomethyl ether (Transcutol ® ).
- a specific solvent such as an alcohol such as ethyl alcohol, or a diethylene glycol ether such as ethoxydiglycol or 1 ' diethylene glycol monomethyl ether (Transcutol ® ).
- Hydrophilic or lipophilic ultraviolet filters and sunscreens can advantageously be incorporated into the composition of the invention, and for example one can incorporate titanium or zinc oxides, or even natural sunscreens such as a Pongamia extract.
- the pH of the composition is preferably between 5.5 and 7.5, and can be adjusted, depending on the compositions, by adding an acid such as citric acid or a base such as hydroxide. sodium.
- the solvent is chosen according to the components used and the form of administration . considered. It may - be constituted by water, and preferably " demineralized water”. ra 'Lrise and a specific solvent such as glycol pxopylène, an alcohol, especially ethanol, or an ether of diethylene glycol.
- compositions may also be advantageous to incorporate into the composition an additional active agent intended to improve the behavior of the skin, such as tocopherol, vitamin A (retinol), retinoic acid, bactericidal agents, etc.
- an additional active agent intended to improve the behavior of the skin, such as tocopherol, vitamin A (retinol), retinoic acid, bactericidal agents, etc.
- capsules or liposomes in order to limit the amounts of emulsifier or solubilizer.
- the encapsulated forms also have the advantage of a controlled release of the active agent over time and therefore a more continuous action. Depending on the size of the capsules, one can also obtain visual and colored effects.
- the capsules used in the invention may contain an envelope of hydroxyethyl cellulose and contain Macadamia oil in combination with the unsaponifiables or the liposoluble body (approx. 20%).
- the rate of encapsulation is generally around 10% (ie 0.2% of unsaponifiables).
- composition in accordance with the present invention can be presented in the forms conventionally used for topical application, that is to say in the form of gel, lotion, emulsion (in particular cream or milk), mask, stick or ointment, containing usual and compatible and pharmaceutically acceptable excipients and carriers.
- These forms of topical administration are prepared by known techniques, and for example, in the case of a cream, by dispersion of a fatty phase in an aqueous phase to obtain an oil-in-water emulsion, or vice versa to prepare a water in oil emulsion.
- creams it is preferred to use emulsions with a lamellar structure containing few or no ethoxylated products.
- compositions can be prepared in accordance with the invention in the form of regenerating or protective creams, regenerating masks, after-sun repairing creams, firming milks, sun products or shampoos.
- an anti-aging cream having the following weight composition is prepared.
- Example 2 An anti-aging serum having the following composition is prepared.
- Nipastat 0, .3 , 0 Tween 20 0.40
- Cocoa amino acids 2.00 Cocoa unsaponifiables capsules
- the mask composition indicated above is prepared by conventional techniques. According to a preferred technique, the fatty substance is melted at a temperature of around 70 ° C. The water and glycols are heated to about 80 ° C, the preservatives are dissolved and cooled to 70 ° C. An emulsion is then formed by mixing the two phases. The mixture is left to cool and the polymer is added at 50 ° C., then mixed for approximately 10 minutes and the Baobab derivative, the cocoa amino acids and the unsaponifiable capsules are added successively at 40 ° C.
- the perfumes are added to the composition at a temperature of approximately 35 ° C.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0007748 | 2000-06-16 | ||
FR0007748A FR2810242B1 (fr) | 2000-06-16 | 2000-06-16 | Composition cosmetique et/ou dermatologique a base d'extraits de cacao |
PCT/FR2001/001885 WO2001095872A1 (fr) | 2000-06-16 | 2001-06-15 | Composition cosmétique et/ou dermatologique à base d'extraits de cacao |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1289491A1 true EP1289491A1 (fr) | 2003-03-12 |
Family
ID=8851371
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP01947503A Withdrawn EP1289491A1 (fr) | 2000-06-16 | 2001-06-15 | Composition cosm tique et/ou dermatologique base d'extraits de cacao |
Country Status (7)
Country | Link |
---|---|
US (1) | US20030170199A1 (fr) |
EP (1) | EP1289491A1 (fr) |
JP (1) | JP2004503481A (fr) |
AU (1) | AU2001269172A1 (fr) |
CA (1) | CA2408575A1 (fr) |
FR (1) | FR2810242B1 (fr) |
WO (1) | WO2001095872A1 (fr) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005119959A1 (fr) * | 2004-06-02 | 2005-12-15 | Nokia Corporation | Signalisation d'accusés de réception pour mecanismes de demande automatique de repetition dans des reseaux sans fil |
WO2006117464A1 (fr) * | 2005-04-29 | 2006-11-09 | Laboratoire Nuxe | Composition a base d'extraits de graines d'araucaria pour la protection de la peau |
WO2006117466A1 (fr) * | 2005-05-04 | 2006-11-09 | Laboratoire Nuxe | Nouvelle utilisation de polyphenols de cacao pour la regulation du cycle cellulaire |
FR2885300A1 (fr) * | 2005-05-04 | 2006-11-10 | Nuxe Sa Lab | Composition topique pour la protection de l'epiderme |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2812873B1 (fr) * | 2000-08-11 | 2003-08-01 | Barry Callebaut France | Procede de production de polyphenols a partir de feves de cacao |
FR2835427B1 (fr) * | 2002-02-04 | 2006-08-04 | Nuxe Lab | Composition cosmetologique et/ou dermatologique a base d'extrait de barbatimao |
FR2849374B1 (fr) * | 2002-12-27 | 2008-05-02 | Yves Derhy | Composition cosmetique et/ou dermatologique a base de pate de cacao |
FR2857588B1 (fr) * | 2003-07-17 | 2007-11-30 | Oreal | Utilisation de beta-endorphine, d'agents exercant une activite beta-endorphine-like en cosmetique et dermatologie |
JP4954450B2 (ja) * | 2004-06-14 | 2012-06-13 | ビーエーエスエフ ビューティ ケア ソリューションズ フランス エスエーエス | 弾性繊維形成の不全、欠損又は無秩序による病状に対処するための、リシルオキシダーゼのアイソフォームの活性の誘導 |
DE102004057858A1 (de) * | 2004-10-15 | 2006-06-29 | Henkel Kgaa | Kosmetische Zusammensetzungen zur Mund- und Zahnhygiene |
FR2885050B1 (fr) * | 2005-04-29 | 2008-09-05 | Nuxe Sa Lab | Composition amincissante a base d'extraits de cacao. |
FR2885299B1 (fr) * | 2005-05-03 | 2009-11-20 | Nuxe Lab | Utilisation de polyphenols de cacao pour reguler la pigmentation de la peau |
FR2892635B1 (fr) * | 2005-10-28 | 2012-11-09 | Engelhard Lyon | Substance pour restaurer une co-expression et une interaction normales entre les proteines lox et nrage |
JP2007119433A (ja) * | 2005-10-31 | 2007-05-17 | Horusu:Kk | 酒粕エキスにイワベンケイエキス等を配合してなる、化粧料、健康食品等の有用素材 |
DE102006033321A1 (de) * | 2006-07-17 | 2008-01-24 | Westfälische Wilhelms-Universität Münster | Medizinische Verwendung von N-Phenylpropenoyl-Aminosäurederivaten und verwandten Verbindungen |
FR2904542B1 (fr) * | 2006-08-03 | 2011-06-24 | Soc Extraction Principes Actif | Utilisation d'un extrait de feves de cacao en tant qu'agent actif pour augmenter la synthese de melanine dans les melanocytes |
GB0719544D0 (en) * | 2007-10-08 | 2007-11-14 | Barry Callebaut Ag | Cocoa extract and use thereof |
GB0719542D0 (en) * | 2007-10-08 | 2007-11-14 | Barry Callebaut Ag | Use of cocoa extract |
GB0719545D0 (en) * | 2007-10-08 | 2007-11-14 | Barry Callebaut Ag | Novel use of cocoa extract |
US9114114B2 (en) | 2007-06-21 | 2015-08-25 | Mars, Inc. | Edible products having a high cocoa polyphenol content and improved flavor and the milled cocoa extracts used therein |
GB0719543D0 (en) * | 2007-10-08 | 2007-11-14 | Barry Callebaut Ag | Cocoa extract and novel use thereof |
US20090263518A1 (en) | 2008-04-17 | 2009-10-22 | Barry Callebaut Ag | Composition and Uses Thereof |
JP2010043027A (ja) * | 2008-08-13 | 2010-02-25 | Kracie Home Products Ltd | 水中油型乳化化粧料 |
FR2939664B1 (fr) | 2008-12-12 | 2011-01-07 | Natura Cosmeticos Sa | Procede d'obtention d'extraits contenant des derives de methylxanthine a partir de gateaux de vegetaux du genre theobroma, et composition et utilisation desdits extraits |
FR2945943B1 (fr) * | 2009-06-01 | 2015-04-03 | Lvmh Rech | Utilisation d'un extrait vegetal riche en polyphenols comme agent antioxydant en association avec un agent hydratant ou humectant |
CA2841133A1 (fr) * | 2011-08-05 | 2013-02-14 | Stemtech International, Inc. | Compositions de soins de la peau contenant des combinaisons d'ingredients naturels |
US9682112B2 (en) | 2013-08-05 | 2017-06-20 | Akay Flavours & Aromatics PVT. LTD | Ultrasound-assisted continuous extraction for complete fragmentation of cocoa beans into fractions |
FR3048881B1 (fr) | 2016-03-16 | 2020-03-27 | Jafer Enterprises R&D, S.L. | Hydrolysat peptidique et osidique des feves de cacao, compositions cosmetiques le comprenant et leurs utilisations cosmetiques |
BE1026464B1 (fr) * | 2018-07-11 | 2020-02-10 | Corman Sa | Procédé d'obtention de fractions spécifiques de beurre de cacao par un ou plusieurs fractionnement(s) |
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US5686082A (en) | 1992-12-24 | 1997-11-11 | L'oreal | Cosmetic or pharmaceutical composition containing a combination of a polyphenol and a ginkgo extract |
US5811083A (en) | 1996-03-26 | 1998-09-22 | Estee Lauder, Inc. | Tocopherol derivatives for use in cosmetic compositions |
FR2779059A1 (fr) | 1998-05-29 | 1999-12-03 | Guerlain | Procede de traitement cosmetique pour lutter contre les effets du vieillissement cutane; nouvelles compositions cosmetiques pour sa mise en oeuvre |
EP1026164A1 (fr) | 1999-02-02 | 2000-08-09 | ADM Cocoa B.V. | Procédé pour l'extraction d'antioxidants polyphénoliques de plantes contenant des purines |
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JPS6281303A (ja) * | 1985-10-01 | 1987-04-14 | Mitsubishi Chem Ind Ltd | 皮膚外用基剤 |
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FR2654935B1 (fr) * | 1989-11-28 | 1994-07-01 | Lvmh Rech | Utilisation de xanthines, eventuellement incorporees dans des liposomes, pour favoriser la pigmentation de la peau ou des cheveux. |
IT1265312B1 (it) * | 1993-12-21 | 1996-10-31 | Indena Spa | Formulazioni contenenti carotenoidi e procarotenoidi associati a polifenoli nella prevenzione dei danni da abnorme produzione di |
JP3063818B2 (ja) * | 1994-04-01 | 2000-07-12 | 明治製菓株式会社 | 胃潰瘍予防飲食品 |
JPH07277938A (ja) * | 1994-04-13 | 1995-10-24 | Pola Chem Ind Inc | 皮膚外用剤 |
US5554645A (en) * | 1994-10-03 | 1996-09-10 | Mars, Incorporated | Antineoplastic cocoa extracts and methods for making and using the same |
FR2728563B1 (fr) * | 1994-12-21 | 1997-07-18 | Ovi Sa | Esters de composes polyhydroxyles aromatiques, leur preparation et leurs applications |
EP0749694A1 (fr) * | 1995-06-20 | 1996-12-27 | Societe Des Produits Nestle S.A. | Traitement enzymatique du cacao |
AU5711696A (en) * | 1996-04-02 | 1997-10-22 | Mars, Incorporated | Cocoa extract compounds and methods for making and using the same |
US6015913A (en) * | 1996-09-06 | 2000-01-18 | Mars, Incorporated | Method for producing fat and/or solids from cocoa beans |
US5961990A (en) * | 1997-05-02 | 1999-10-05 | Kobo Products S.A.R.L. | Cosmetic particulate gel delivery system and method of preparing complex gel particles |
US8507018B2 (en) * | 1998-03-12 | 2013-08-13 | Mars, Incorporated | Products containing polyphenol(s) and L-arginine and methods of use thereof |
JPH11335231A (ja) * | 1998-05-20 | 1999-12-07 | Shiseido Co Ltd | 痩身用皮膚外用剤 |
JP2000119155A (ja) * | 1998-10-14 | 2000-04-25 | Kose Corp | 皮膚外用剤 |
JP4201898B2 (ja) * | 1998-10-21 | 2008-12-24 | 株式会社ロッテ | 抗菌製剤 |
KR100319251B1 (ko) * | 1999-06-30 | 2002-01-05 | 한수길 | 충치 억제 효능을 지닌 카카오 콩껍질 분획물의 제조방법 |
US6207702B1 (en) * | 1999-11-17 | 2001-03-27 | Mars, Incorporated | Method for reducing postprandial oxidative stress using cocoa procyanidins |
-
2000
- 2000-06-16 FR FR0007748A patent/FR2810242B1/fr not_active Expired - Lifetime
-
2001
- 2001-06-15 CA CA002408575A patent/CA2408575A1/fr not_active Abandoned
- 2001-06-15 EP EP01947503A patent/EP1289491A1/fr not_active Withdrawn
- 2001-06-15 US US10/311,544 patent/US20030170199A1/en not_active Abandoned
- 2001-06-15 AU AU2001269172A patent/AU2001269172A1/en not_active Abandoned
- 2001-06-15 WO PCT/FR2001/001885 patent/WO2001095872A1/fr active Application Filing
- 2001-06-15 JP JP2002510052A patent/JP2004503481A/ja active Pending
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US5686082A (en) | 1992-12-24 | 1997-11-11 | L'oreal | Cosmetic or pharmaceutical composition containing a combination of a polyphenol and a ginkgo extract |
US5811083A (en) | 1996-03-26 | 1998-09-22 | Estee Lauder, Inc. | Tocopherol derivatives for use in cosmetic compositions |
FR2779059A1 (fr) | 1998-05-29 | 1999-12-03 | Guerlain | Procede de traitement cosmetique pour lutter contre les effets du vieillissement cutane; nouvelles compositions cosmetiques pour sa mise en oeuvre |
WO1999062481A1 (fr) | 1998-05-29 | 1999-12-09 | Guerlain S.A. | Procede de traitement cosmetique pour lutter contre les effets du vieillissement cutane |
EP1026164A1 (fr) | 1999-02-02 | 2000-08-09 | ADM Cocoa B.V. | Procédé pour l'extraction d'antioxidants polyphénoliques de plantes contenant des purines |
Non-Patent Citations (2)
Title |
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See also references of WO0195872A1 |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005119959A1 (fr) * | 2004-06-02 | 2005-12-15 | Nokia Corporation | Signalisation d'accusés de réception pour mecanismes de demande automatique de repetition dans des reseaux sans fil |
WO2006117464A1 (fr) * | 2005-04-29 | 2006-11-09 | Laboratoire Nuxe | Composition a base d'extraits de graines d'araucaria pour la protection de la peau |
WO2006117466A1 (fr) * | 2005-05-04 | 2006-11-09 | Laboratoire Nuxe | Nouvelle utilisation de polyphenols de cacao pour la regulation du cycle cellulaire |
FR2885300A1 (fr) * | 2005-05-04 | 2006-11-10 | Nuxe Sa Lab | Composition topique pour la protection de l'epiderme |
FR2885297A1 (fr) * | 2005-05-04 | 2006-11-10 | Nuxe Sa Lab | Nouvelle utilisation de polyphenols de cacao pour la regulation de cycle cellulaire. |
Also Published As
Publication number | Publication date |
---|---|
US20030170199A1 (en) | 2003-09-11 |
FR2810242B1 (fr) | 2003-01-17 |
CA2408575A1 (fr) | 2001-12-20 |
AU2001269172A1 (en) | 2001-12-24 |
FR2810242A1 (fr) | 2001-12-21 |
WO2001095872A1 (fr) | 2001-12-20 |
JP2004503481A (ja) | 2004-02-05 |
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