EP1278452A1 - Nichtinwasive messung von blutbestandteilen unter verwendung von retinalbildgebung - Google Patents
Nichtinwasive messung von blutbestandteilen unter verwendung von retinalbildgebungInfo
- Publication number
- EP1278452A1 EP1278452A1 EP00926006A EP00926006A EP1278452A1 EP 1278452 A1 EP1278452 A1 EP 1278452A1 EP 00926006 A EP00926006 A EP 00926006A EP 00926006 A EP00926006 A EP 00926006A EP 1278452 A1 EP1278452 A1 EP 1278452A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- light
- fundus
- wavelengths
- image
- eye
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000012503 blood component Substances 0.000 title claims abstract description 26
- 238000005259 measurement Methods 0.000 title abstract description 24
- 238000003384 imaging method Methods 0.000 title description 18
- 230000002207 retinal effect Effects 0.000 title description 14
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 claims abstract description 100
- 108010054147 Hemoglobins Proteins 0.000 claims abstract description 22
- 102000001554 Hemoglobins Human genes 0.000 claims abstract description 22
- 239000012491 analyte Substances 0.000 claims abstract description 22
- 210000003733 optic disk Anatomy 0.000 claims abstract description 22
- 210000001747 pupil Anatomy 0.000 claims abstract description 12
- 239000000306 component Substances 0.000 claims abstract description 7
- 238000000034 method Methods 0.000 claims description 34
- 210000004369 blood Anatomy 0.000 claims description 23
- 239000008280 blood Substances 0.000 claims description 23
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 9
- 230000017531 blood circulation Effects 0.000 claims description 9
- 239000008103 glucose Substances 0.000 claims description 9
- 210000004204 blood vessel Anatomy 0.000 claims description 6
- 210000004087 cornea Anatomy 0.000 claims description 4
- 238000004891 communication Methods 0.000 claims description 3
- 238000001514 detection method Methods 0.000 claims description 3
- 210000001232 limbus corneae Anatomy 0.000 claims description 3
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 1
- 210000001525 retina Anatomy 0.000 abstract description 35
- 238000005286 illumination Methods 0.000 abstract description 24
- 210000001210 retinal vessel Anatomy 0.000 abstract description 6
- 239000000126 substance Substances 0.000 abstract description 5
- 230000003595 spectral effect Effects 0.000 abstract description 3
- 238000004458 analytical method Methods 0.000 description 18
- 210000002966 serum Anatomy 0.000 description 12
- 230000003287 optical effect Effects 0.000 description 9
- 238000013528 artificial neural network Methods 0.000 description 8
- 230000006870 function Effects 0.000 description 8
- 230000001537 neural effect Effects 0.000 description 8
- 238000000338 in vitro Methods 0.000 description 6
- INGWEZCOABYORO-UHFFFAOYSA-N 2-(furan-2-yl)-7-methyl-1h-1,8-naphthyridin-4-one Chemical compound N=1C2=NC(C)=CC=C2C(O)=CC=1C1=CC=CO1 INGWEZCOABYORO-UHFFFAOYSA-N 0.000 description 5
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- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 230000033001 locomotion Effects 0.000 description 5
- 108010064719 Oxyhemoglobins Proteins 0.000 description 4
- 210000002159 anterior chamber Anatomy 0.000 description 4
- 108010002255 deoxyhemoglobin Proteins 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
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- 206010023126 Jaundice Diseases 0.000 description 3
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- 230000031700 light absorption Effects 0.000 description 3
- 238000003909 pattern recognition Methods 0.000 description 3
- 230000004256 retinal image Effects 0.000 description 3
- 238000012935 Averaging Methods 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 238000004159 blood analysis Methods 0.000 description 2
- 238000009534 blood test Methods 0.000 description 2
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- 229910052736 halogen Inorganic materials 0.000 description 2
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- 210000005036 nerve Anatomy 0.000 description 2
- 210000001328 optic nerve Anatomy 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 230000010349 pulsation Effects 0.000 description 2
- 210000001927 retinal artery Anatomy 0.000 description 2
- 208000021130 Bilirubin encephalopathy Diseases 0.000 description 1
- 208000002177 Cataract Diseases 0.000 description 1
- 208000001860 Eye Infections Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 235000009714 Hyptis pectinata Nutrition 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 241000320681 Tridens flavus Species 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 238000004422 calculation algorithm Methods 0.000 description 1
- 210000003161 choroid Anatomy 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000010339 dilation Effects 0.000 description 1
- 210000000624 ear auricle Anatomy 0.000 description 1
- 208000011323 eye infectious disease Diseases 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000003331 infrared imaging Methods 0.000 description 1
- 208000006663 kernicterus Diseases 0.000 description 1
- 238000011545 laboratory measurement Methods 0.000 description 1
- 238000011005 laboratory method Methods 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 208000012866 low blood pressure Diseases 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000002911 mydriatic effect Effects 0.000 description 1
- 238000012624 non-invasive in vivo measurement Methods 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 238000006552 photochemical reaction Methods 0.000 description 1
- 238000001126 phototherapy Methods 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
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- 229920002223 polystyrene Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 210000001957 retinal vein Anatomy 0.000 description 1
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- 201000008525 senile cataract Diseases 0.000 description 1
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- 230000035939 shock Effects 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
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- 238000012546 transfer Methods 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/14—Arrangements specially adapted for eye photography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
- A61B3/1241—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes specially adapted for observation of ocular blood flow, e.g. by fluorescein angiography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0004—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the type of physiological signal transmitted
- A61B5/0013—Medical image data
Definitions
- Fig. 9 is a graph of the intensity of light at 550 nm reflected from the retina showing the effect of single pulse illumination at 470 nm.
- Fig. 1 illustrates a blood analysis 5 apparatus of the invention in conjunction with the eye of the patient, shown illustratively at 10 in Fig. 1.
- the blood analysis apparatus includes an optics system 11 comprised of lenses for projecting illuminating light onto the fundus, generally although not necessarily directly through the pupil, and for receiving the light reflected from the fundus passed out through the pupil, and for focusing that
- Fig. 3 illustrates a hand-held camera and illumination unit 25 for the analysis system of the invention in which the optic system 11 is mounted
- Fig. 4 illustrates the output viewing system 14 at the back end of the hand-held unit 25 to enable the operator to review the image being obtained of the retina on a real-time basis.
- a disposable transparent plastic e.g. polyethylene, polystyrene, polypropylene, etc.
- Eye infections are particularly common in newborns and a cover would assist in the prevention of these infections.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Optics & Photonics (AREA)
- Pathology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Emergency Medicine (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Eye Examination Apparatus (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2000/010088 WO2001078589A1 (en) | 2000-04-14 | 2000-04-14 | Non-invasive measurement of blood components using retinal imaging |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP1278452A1 true EP1278452A1 (de) | 2003-01-29 |
| EP1278452A4 EP1278452A4 (de) | 2005-04-13 |
Family
ID=21741278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP00926006A Withdrawn EP1278452A4 (de) | 2000-04-14 | 2000-04-14 | Nichtinwasive messung von blutbestandteilen unter verwendung von retinalbildgebung |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1278452A4 (de) |
| JP (1) | JP2003532461A (de) |
| AU (1) | AU2000244608A1 (de) |
| WO (1) | WO2001078589A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2375679A (en) * | 2001-04-09 | 2002-11-20 | Patrick Kerr | Retinal function camera using plural light wavelengths to produce a retinal function image showing haemoglobin oxygenation. |
| US6709109B1 (en) | 2002-04-16 | 2004-03-23 | University Of South Florida | Differential spectroscopic imaging of the human retina |
| DE102004016435B4 (de) * | 2004-03-31 | 2009-05-28 | Imedos Gmbh | Verfahren zur spektralphotometrischen Ermittlung der Sauerstoffsättigung des Blutes in optisch zugänglichen Blutgefäßen |
| EP1793732A4 (de) * | 2004-09-29 | 2009-11-11 | Univ Delaware | Vorrichtung für ir-spektrographie und verfahren zur krankheitsdiagnose |
| JP5129549B2 (ja) * | 2007-11-19 | 2013-01-30 | パナソニック株式会社 | 光走査測定装置 |
| JP5388765B2 (ja) * | 2009-09-01 | 2014-01-15 | キヤノン株式会社 | 眼底カメラ |
| US9459201B2 (en) | 2014-09-29 | 2016-10-04 | Zyomed Corp. | Systems and methods for noninvasive blood glucose and other analyte detection and measurement using collision computing |
| US9554738B1 (en) | 2016-03-30 | 2017-01-31 | Zyomed Corp. | Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing |
| WO2018208233A1 (en) * | 2017-05-12 | 2018-11-15 | National University Of Singapore | Noninvasive optical sensor for analyzing a level of a substance in a subject by illuminating the sclera |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4267844A (en) * | 1978-05-15 | 1981-05-19 | Minolta Camera Kabushiki Kaisha | Medical instrument for determining jaundice |
| DE19741198A1 (de) * | 1996-12-06 | 1998-06-18 | Siemens Ag | Gerät zur nichtinvasiven Messung von Vitalparametern |
| US5791345A (en) * | 1993-09-03 | 1998-08-11 | Toa Medical Electronics Co., Ltd. | Non-invasive blood analyzer |
| US5836872A (en) * | 1989-04-13 | 1998-11-17 | Vanguard Imaging, Ltd. | Digital optical visualization, enhancement, quantification, and classification of surface and subsurface features of body surfaces |
| GB2342182A (en) * | 1998-09-11 | 2000-04-05 | Keeler Ltd | Ophthalmoscope |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4877322A (en) * | 1987-04-30 | 1989-10-31 | Eyedentify, Inc. | Method and apparatus for measuring blood oxygen levels in selected areas of the eye fundus |
| JP3562847B2 (ja) * | 1994-11-15 | 2004-09-08 | 謙 石原 | ヘモグロビン濃度測定装置 |
| US5919132A (en) * | 1998-03-26 | 1999-07-06 | Universite De Montreal | On-line and real-time spectroreflectometry measurement of oxygenation in a patient's eye |
-
2000
- 2000-04-14 AU AU2000244608A patent/AU2000244608A1/en not_active Abandoned
- 2000-04-14 EP EP00926006A patent/EP1278452A4/de not_active Withdrawn
- 2000-04-14 WO PCT/US2000/010088 patent/WO2001078589A1/en not_active Application Discontinuation
- 2000-04-14 JP JP2001575895A patent/JP2003532461A/ja active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4267844A (en) * | 1978-05-15 | 1981-05-19 | Minolta Camera Kabushiki Kaisha | Medical instrument for determining jaundice |
| US5836872A (en) * | 1989-04-13 | 1998-11-17 | Vanguard Imaging, Ltd. | Digital optical visualization, enhancement, quantification, and classification of surface and subsurface features of body surfaces |
| US5791345A (en) * | 1993-09-03 | 1998-08-11 | Toa Medical Electronics Co., Ltd. | Non-invasive blood analyzer |
| DE19741198A1 (de) * | 1996-12-06 | 1998-06-18 | Siemens Ag | Gerät zur nichtinvasiven Messung von Vitalparametern |
| GB2342182A (en) * | 1998-09-11 | 2000-04-05 | Keeler Ltd | Ophthalmoscope |
Non-Patent Citations (1)
| Title |
|---|
| See also references of WO0178589A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003532461A (ja) | 2003-11-05 |
| WO2001078589A1 (en) | 2001-10-25 |
| AU2000244608A1 (en) | 2001-10-30 |
| EP1278452A4 (de) | 2005-04-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 20021017 |
|
| AK | Designated contracting states |
Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
| AX | Request for extension of the european patent |
Extension state: AL LT LV MK RO SI |
|
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20050228 |
|
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7A 61B 3/14 B Ipc: 7A 61B 5/00 A |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 20060321 |