EP1263765A4 - Modification de comportement cellulaire par modulation antisens de la maturation d'arn messager - Google Patents
Modification de comportement cellulaire par modulation antisens de la maturation d'arn messagerInfo
- Publication number
- EP1263765A4 EP1263765A4 EP00919726A EP00919726A EP1263765A4 EP 1263765 A4 EP1263765 A4 EP 1263765A4 EP 00919726 A EP00919726 A EP 00919726A EP 00919726 A EP00919726 A EP 00919726A EP 1263765 A4 EP1263765 A4 EP 1263765A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- alteration
- mrna processing
- antisense modulation
- cellular behavior
- antisense
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
Abstract
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2000/008174 WO2001072765A1 (fr) | 2000-03-28 | 2000-03-28 | Modification de comportement cellulaire par modulation antisens de la maturation d'arn messager |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1263765A1 EP1263765A1 (fr) | 2002-12-11 |
EP1263765A4 true EP1263765A4 (fr) | 2005-06-29 |
Family
ID=21741209
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00919726A Withdrawn EP1263765A4 (fr) | 2000-03-28 | 2000-03-28 | Modification de comportement cellulaire par modulation antisens de la maturation d'arn messager |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1263765A4 (fr) |
JP (1) | JP2004509604A (fr) |
AU (2) | AU2000240366B2 (fr) |
CA (1) | CA2400573A1 (fr) |
WO (1) | WO2001072765A1 (fr) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20020097241A (ko) | 2000-05-04 | 2002-12-31 | 에이브이아이 바이오파마 인코포레이티드 | 스플라이스-영역 안티센스 조성물 및 방법 |
US7407943B2 (en) | 2001-08-01 | 2008-08-05 | Isis Pharmaceuticals, Inc. | Antisense modulation of apolipoprotein B expression |
EP2336319A1 (fr) * | 2002-11-13 | 2011-06-22 | Genzyme Corporation | Modulation anti-sens d'expression B apolipoprotéine |
US7511131B2 (en) | 2002-11-13 | 2009-03-31 | Genzyme Corporation | Antisense modulation of apolipoprotein B expression |
WO2004044181A2 (fr) * | 2002-11-13 | 2004-05-27 | Isis Pharmaceuticals, Inc. | Modulation antisens de l'expression d'apolipoproteine b |
JP4762889B2 (ja) * | 2003-03-12 | 2011-08-31 | バスジーン セラピューティクス,インコーポレイテッド | 血管形成及び腫瘍成長を阻止するための核酸化合物 |
US20050222068A1 (en) | 2003-10-23 | 2005-10-06 | Mourich Dan V | Method and antisense composition for selective inhibition of HIV infection in hematopoietic cells |
EP1711606A2 (fr) * | 2004-01-20 | 2006-10-18 | Isis Pharmaceuticals, Inc. | Modulation de l'expression du r cepteur glucocortico de |
WO2005072527A2 (fr) | 2004-01-23 | 2005-08-11 | Avi Biopharma, Inc. | Oligomeres antisens et methodes destinees a induire la tolerance immunitaire et l'immunosuppression |
US20050287558A1 (en) | 2004-05-05 | 2005-12-29 | Crooke Rosanne M | SNPs of apolipoprotein B and modulation of their expression |
EP3228711A1 (fr) | 2004-06-28 | 2017-10-11 | The University Of Western Australia | Oligonucléotides antisens permettant d'induire un saut d'exon et leurs procédés d'utilisation |
AU2006213686A1 (en) | 2005-02-09 | 2006-08-17 | Avi Bio Pharma, Inc. | Antisense composition and method for treating muscle atrophy |
AU2007257093A1 (en) | 2006-05-05 | 2007-12-13 | Isis Pharmaceuticals, Inc. | Compounds and methods for modulating expression of PCSK9 |
CN103480002A (zh) | 2007-03-24 | 2014-01-01 | 基酶有限公司 | 施用与人载脂蛋白 b互补的反义寡核苷酸 |
CA2710013A1 (fr) | 2007-12-28 | 2009-07-09 | Avi Biopharma, Inc. | Agents immunomodulatoires et procedes d'utilisation |
CN105779453A (zh) | 2008-10-24 | 2016-07-20 | 萨雷普塔治疗公司 | 用于dmd的多外显子跳跃组合物 |
WO2010080554A1 (fr) | 2008-12-17 | 2010-07-15 | Avi Biopharma, Inc. | Compositions antisens et méthodes de modulation de l'hypersensibilité de contact ou de la dermatite de contact |
EP2408796B1 (fr) | 2009-03-16 | 2020-04-22 | Ionis Pharmaceuticals, Inc. | Ciblage de l'Apolipoprotéine B pour la réduction de l'apolipoprotéine C-III |
JP5963678B2 (ja) | 2009-11-12 | 2016-08-03 | ジ ユニバーシティ オブ ウェスタン オーストラリア | 病状を治療するためのアンチセンス分子及び方法 |
US20130085139A1 (en) | 2011-10-04 | 2013-04-04 | Royal Holloway And Bedford New College | Oligomers |
JP6105041B2 (ja) | 2012-03-28 | 2017-03-29 | エシコン・エンド−サージェリィ・インコーポレイテッドEthicon Endo−Surgery,Inc. | 低圧環境を画定するカプセルを含む組織厚コンペンセーター |
JP6492003B2 (ja) * | 2012-03-30 | 2019-03-27 | ワシントン・ユニバーシティWashington University | 発作を減少させるためおよび神経変性症候群を改質するためにタウ発現を調節する方法 |
EP2850186B1 (fr) | 2012-05-16 | 2018-12-19 | Translate Bio MA, Inc. | Compositions et procédés de modulation de l'expression de la famille génique smn |
AU2013262709A1 (en) | 2012-05-16 | 2015-01-22 | Rana Therapeutics, Inc. | Compositions and methods for modulating MECP2 expression |
US10837014B2 (en) | 2012-05-16 | 2020-11-17 | Translate Bio Ma, Inc. | Compositions and methods for modulating SMN gene family expression |
JP6449231B2 (ja) | 2013-03-14 | 2019-01-09 | サレプタ セラピューティクス, インコーポレイテッド | 筋ジストロフィを処置するためのエキソンスキッピング組成物 |
CN111254145A (zh) * | 2013-03-14 | 2020-06-09 | Ionis制药公司 | 用于调节tau表达的组合物和方法 |
MX2015013117A (es) | 2013-03-15 | 2016-07-14 | Sarepta Therapeutics Inc | Composiciones mejoradas para tratar distrofia muscular. |
EP2986599A1 (fr) | 2013-04-17 | 2016-02-24 | Pfizer Inc. | Dérivés de n-pipéridin-3-ylbenzamide dans le traitement des maladies cardiovasculaires |
TW202246503A (zh) | 2013-07-19 | 2022-12-01 | 美商百健Ma公司 | 用於調節τ蛋白表現之組合物 |
WO2015051283A1 (fr) | 2013-10-04 | 2015-04-09 | Rana Therapeutics, Inc. | Compositions et méthodes pour traiter la sclérose latérale amyotrophique (sla) |
MA41795A (fr) | 2015-03-18 | 2018-01-23 | Sarepta Therapeutics Inc | Exclusion d'un exon induite par des composés antisens dans la myostatine |
JOP20190065A1 (ar) | 2016-09-29 | 2019-03-28 | Ionis Pharmaceuticals Inc | مركبات وطرق لتقليل التعبير عن tau |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000008044A1 (fr) * | 1998-08-07 | 2000-02-17 | Isis Pharmaceuticals, Inc. | Oligonucleotides 2'-o-aminoethyloxyethyle-modifies |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100252547B1 (ko) * | 1991-09-05 | 2000-09-01 | 프레드 마리얀스키 | 폴리-또는 올리고누클레오티드의 세포로의 표적화된 전달 |
CA2162361C (fr) * | 1993-05-11 | 2008-10-21 | Ryszard Kole | Oligonucleotides antisens actifs contre l'epissage aberrant; methodes d'utilisation |
US6040296A (en) * | 1995-06-07 | 2000-03-21 | East Carolina University | Specific antisense oligonucleotide composition & method for treatment of disorders associated with bronchoconstriction and lung inflammation |
US5776905A (en) * | 1996-08-08 | 1998-07-07 | The Board Of Trustees Of The Leland Stamford Junior University | Apoptotic regression of intimal vascular lesions |
US6214986B1 (en) * | 1998-10-07 | 2001-04-10 | Isis Pharmaceuticals, Inc. | Antisense modulation of bcl-x expression |
-
2000
- 2000-03-28 AU AU2000240366A patent/AU2000240366B2/en not_active Expired
- 2000-03-28 WO PCT/US2000/008174 patent/WO2001072765A1/fr active IP Right Grant
- 2000-03-28 EP EP00919726A patent/EP1263765A4/fr not_active Withdrawn
- 2000-03-28 JP JP2001571696A patent/JP2004509604A/ja active Pending
- 2000-03-28 AU AU4036600A patent/AU4036600A/xx active Pending
- 2000-03-28 CA CA002400573A patent/CA2400573A1/fr not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000008044A1 (fr) * | 1998-08-07 | 2000-02-17 | Isis Pharmaceuticals, Inc. | Oligonucleotides 2'-o-aminoethyloxyethyle-modifies |
Non-Patent Citations (3)
Title |
---|
BAKER B F ET AL: "2'-O-(2-METHOXY)ETHYL-MODIFIED ANTI-INTERCELLULAR ADHESION MOLECULE 1 (ICAM-1) OLIGONUCLEOTIDES SELECTIVELY INCREASE THE ICAM-1 MRNA LEVEL AND INHIBIT FORMATION OF THE ICAM-1 TRANSLATION INITIATION COMPLEX IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 272, no. 18, 2 May 1997 (1997-05-02), pages 11994 - 12000, XP002948752, ISSN: 0021-9258 * |
See also references of WO0172765A1 * |
SIERAKOWSKA HALINA ET AL: "Restoration of beta-globin gene expression in mammalian cells by antisense oligonucleotides that modify the aberrant splicing patterns of thalassemic pre-mRNAs", NUCLEOSIDES AND NUCLEOTIDES, vol. 16, no. 7-9, July 1997 (1997-07-01), pages 1173 - 1182, XP008042383, ISSN: 0732-8311 * |
Also Published As
Publication number | Publication date |
---|---|
JP2004509604A (ja) | 2004-04-02 |
CA2400573A1 (fr) | 2001-10-04 |
AU4036600A (en) | 2001-10-08 |
AU2000240366B2 (en) | 2005-08-04 |
EP1263765A1 (fr) | 2002-12-11 |
WO2001072765A1 (fr) | 2001-10-04 |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
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RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: ISIS PHARMACEUTICALS, INC. |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7C 12N 15/86 B Ipc: 7C 12Q 1/68 B Ipc: 7A 01N 43/04 B Ipc: 7C 12N 15/85 B Ipc: 7C 12N 15/11 B Ipc: 7A 61K 31/70 B Ipc: 7C 07H 21/04 B Ipc: 7C 07H 21/02 A |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 20050511 |
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