EP1214443A4 - RESTORATION OF THE TELOMER AND EXTENSION OF THE CELL LIFETIME IN CLONED ANIMALS FROM SENESCENT SOMATIC CELLS - Google Patents

RESTORATION OF THE TELOMER AND EXTENSION OF THE CELL LIFETIME IN CLONED ANIMALS FROM SENESCENT SOMATIC CELLS

Info

Publication number
EP1214443A4
EP1214443A4 EP00961569A EP00961569A EP1214443A4 EP 1214443 A4 EP1214443 A4 EP 1214443A4 EP 00961569 A EP00961569 A EP 00961569A EP 00961569 A EP00961569 A EP 00961569A EP 1214443 A4 EP1214443 A4 EP 1214443A4
Authority
EP
European Patent Office
Prior art keywords
repairing
cell
extending
dna sequences
life span
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP00961569A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1214443A1 (en
Inventor
Michael West
Robert L Lanza
Jose Cibelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Institute for Regenerative Medicine
Original Assignee
Advanced Cell Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Cell Technology Inc filed Critical Advanced Cell Technology Inc
Publication of EP1214443A1 publication Critical patent/EP1214443A1/en
Publication of EP1214443A4 publication Critical patent/EP1214443A4/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/04—Cells produced using nuclear transfer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Psychology (AREA)
  • Virology (AREA)
  • Reproductive Health (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • AIDS & HIV (AREA)
  • Obesity (AREA)
EP00961569A 1999-09-07 2000-09-06 RESTORATION OF THE TELOMER AND EXTENSION OF THE CELL LIFETIME IN CLONED ANIMALS FROM SENESCENT SOMATIC CELLS Ceased EP1214443A4 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US15234099P 1999-09-07 1999-09-07
US152340P 1999-09-07
US17948600P 2000-02-01 2000-02-01
US179486P 2000-02-01
US52702600A 2000-03-16 2000-03-16
US527026 2000-03-16
US52087900A 2000-04-05 2000-04-05
US520879 2000-04-05
PCT/US2000/024393 WO2001018236A1 (en) 1999-09-07 2000-09-06 Telomere restoration and extension of cell life-span in animals cloned from senescent somatic cells

Publications (2)

Publication Number Publication Date
EP1214443A1 EP1214443A1 (en) 2002-06-19
EP1214443A4 true EP1214443A4 (en) 2003-08-27

Family

ID=27496015

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00961569A Ceased EP1214443A4 (en) 1999-09-07 2000-09-06 RESTORATION OF THE TELOMER AND EXTENSION OF THE CELL LIFETIME IN CLONED ANIMALS FROM SENESCENT SOMATIC CELLS

Country Status (10)

Country Link
EP (1) EP1214443A4 (https=)
JP (1) JP2003508079A (https=)
CN (1) CN1377424A (https=)
AU (1) AU7350800A (https=)
BR (1) BR0013844A (https=)
CA (1) CA2383790C (https=)
IL (2) IL148457A0 (https=)
MX (1) MXPA02002443A (https=)
NZ (1) NZ531844A (https=)
WO (1) WO2001018236A1 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001018193A1 (en) * 1999-09-07 2001-03-15 Advanced Cell Technology, Inc. Method for generating immune-compatible cells and tissues using nuclear transfer techniques
US7947457B2 (en) 2007-01-08 2011-05-24 The Invention Science Fund I, Llc Systems for genome selection
US7709245B2 (en) 2007-01-08 2010-05-04 The Invention Science Fund I, Llc Systems for genome selection
US8003371B2 (en) 2007-01-08 2011-08-23 The Invention Science Fund I, Llc Systems for genome selection
US7718418B2 (en) 2007-01-08 2010-05-18 The Invention Science Fund I, Llc Systems for genome selection
US7709244B2 (en) 2007-01-08 2010-05-04 The Invention Science Fund I, Llc Systems for genome selection
US8012740B2 (en) 2007-01-08 2011-09-06 The Invention Science Fund I, Llc Systems for genome selection
US7947455B2 (en) 2007-01-08 2011-05-24 The Invention Science Fund I, Llc System for genome selection
US7985578B2 (en) 2007-01-08 2011-07-26 The Invention Science Fund I, Llc Systems for genome selection
US8521440B2 (en) 2007-01-08 2013-08-27 The Invention Science Fund I, Llc Systems for genome selection
US7648823B2 (en) 2007-01-08 2010-01-19 Searete Llc Systems for genome selection
US7713728B2 (en) 2007-01-08 2010-05-11 The Invention Sciencefund I, Llc Systems for genome selection
US20110086424A1 (en) * 2008-05-06 2011-04-14 Advanced Cell Technology, Inc. Methods for producing enucleated erythroid cells derived from pluripotent stem cells
JP5888852B2 (ja) * 2010-12-08 2016-03-22 学校法人近畿大学 免疫不全動物を用いた細胞の製法
CN103562376B (zh) * 2011-04-08 2017-12-29 国家医疗保健研究所 复壮细胞的方法
EP3782628B1 (en) * 2013-03-15 2024-08-07 Elixirgen Therapeutics, Inc. Methods of using zscan4 for rejuvenating human cells
SG10201907918VA (en) 2015-03-23 2019-10-30 Astellas Inst For Regenerative Medicine Improved assays for potency of human retinal pigment epithelium (rpe) cells and photoreceptor progenitors
CN112654244B (zh) * 2018-09-06 2023-07-25 德克萨斯大学系统董事会 端粒酶全酶复合体及其使用方法
EP4525895A1 (en) * 2022-05-17 2025-03-26 National University of Singapore Chimeric ovarian follicle-based therapy to treat female infertility

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999055841A2 (en) * 1998-04-29 1999-11-04 University Of Edinburgh Process for obtaining stem cells
WO2001000650A1 (en) * 1999-06-30 2001-01-04 Advanced Cell Technology, Inc. Cytoplasmic transfer to de-differentiate recipient cells
WO2001018193A1 (en) * 1999-09-07 2001-03-15 Advanced Cell Technology, Inc. Method for generating immune-compatible cells and tissues using nuclear transfer techniques

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5489508A (en) * 1992-05-13 1996-02-06 University Of Texas System Board Of Regents Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US5648215A (en) * 1992-05-13 1997-07-15 Board Of Regents, The University Of Texas System Telomerase diagnostic methods
US5945577A (en) * 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells
AU745334B2 (en) * 1997-03-06 2002-03-21 Advanced Cell Technology, Inc. Method of cloning animals

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999055841A2 (en) * 1998-04-29 1999-11-04 University Of Edinburgh Process for obtaining stem cells
WO2001000650A1 (en) * 1999-06-30 2001-01-04 Advanced Cell Technology, Inc. Cytoplasmic transfer to de-differentiate recipient cells
WO2001018193A1 (en) * 1999-09-07 2001-03-15 Advanced Cell Technology, Inc. Method for generating immune-compatible cells and tissues using nuclear transfer techniques

Non-Patent Citations (29)

* Cited by examiner, † Cited by third party
Title
ALBANELL J. ET AL: "Telomerase activity in germ cell cancers and mature teratomas", JOURNAL OF THE NATIONAL CANCER INSTITUTE (BETHESDA), vol. 91, no. 15, 4 August 1999 (1999-08-04), pages 1321 - 1326, ISSN: 0027-8874 *
ANDERSON G.B. ET AL.: "Development of bovine and porcine embryonic teratomas in athymic mice", ANIMAL REPRODUCTION SCIENCE, vol. 45, 1996, pages 231 - 240 *
BETTS D. ET AL: "Reprogramming of telomerase activity and rebuilding of telomere length in cloned cattle.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 30 JAN 2001 LNKD- PUBMED:11158597, vol. 98, no. 3, 30 January 2001 (2001-01-30), pages 1077 - 1082, ISSN: 0027-8424 *
BETTS D.H. ET AL: "Telomere length analysis in goat clones and their offspring", MOLECULAR REPRODUCTION AND DEVELOPMENT, vol. 72, no. 4, December 2005 (2005-12-01), pages 461 - 470, ISSN: 1040-452X *
CIBELLI ET AL: "Cloned transgenic calves produced from non quiescent fetal fibroblasts", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 5367, no. 280, 1998, pages 1256 - 1258, XP002079366, ISSN: 0036-8075 *
CIBELLI J B ET AL: "Transgenic bovine chimeric offspring produced from somatic cell-derived stem-like cells", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 16, July 1998 (1998-07-01), pages 642 - 646, XP002938434, ISSN: 1087-0156 *
JEON H.Y. ET AL: "The analysis of telomere length and telomerase activity in cloned pigs and cows.", MOLECULAR REPRODUCTION AND DEVELOPMENT JUL 2005 LNKD- PUBMED:15806556, vol. 71, no. 3, July 2005 (2005-07-01), pages 315 - 320, ISSN: 1040-452X *
JIANG L. ET AL: "Telomere lengths in cloned transgenic pigs", BIOLOGY OF REPRODUCTION, vol. 70, 2004, pages 1589 - 1593 *
JIANG L. ET AL: "Telomere lengths in cloned transgenic pigs.", BIOLOGY OF REPRODUCTION JUN 2004 LNKD- PUBMED:14749296, vol. 70, no. 6, June 2004 (2004-06-01), pages 1589 - 1593, ISSN: 0006-3363 *
KISHIGAMI S ET AL: "Somatic cell nuclear transfer: Infinite reproduction of a unique diploid genome", EXPERIMENTAL CELL RESEARCH, ACADEMIC PRESS, US, vol. 314, no. 9, 10 June 2008 (2008-06-10), pages 1945 - 1950, XP022652728, ISSN: 0014-4827, [retrieved on 20080212], DOI: 10.1016/J.YEXCR.2008.01.027 *
KUBOTA CHIKARA ET AL: "Six cloned calves produced from adult fibroblast cells after long-term culture.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 97, no. 3, 1 February 2000 (2000-02-01), Feb. 1, 2000, pages 990 - 995, XP001126944, ISSN: 0027-8424 *
LANZA R P ET AL: "Prospects for the use of nuclear transfer in human transplantation", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 17, no. 12, December 1999 (1999-12-01), pages 1171 - 1174, XP000978949, ISSN: 1087-0156 *
LANZA ROBERT P ET AL: "Extension of cell life-span and telomere length in animals cloned from senescent somatic cells.", SCIENCE (WASHINGTON D C), vol. 288, no. 5466, 28 April 2000 (2000-04-28), pages 665 - 669, XP001126945, ISSN: 0036-8075 *
MARTIN G.R.: "Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA DEC 1981 LNKD- PUBMED:6950406, vol. 78, no. 12, December 1981 (1981-12-01), pages 7634 - 7638, ISSN: 0027-8424 *
MIYASHITA N. ET AL: "Remarkable differences in telomere lengths among cloned cattle derived from different cell types", BIOLOGY OF REPRODUCTION, vol. 66, no. 6, June 2002 (2002-06-01), pages 1649 - 1655, ISSN: 0006-3363 *
SCHAETZLEIN S. ET AL: "Telomere length is reset during early mammalian embryogenesis.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 25 MAY 2004 LNKD- PUBMED:15148368, vol. 101, no. 21, 25 May 2004 (2004-05-25), pages 8034 - 8038, ISSN: 0027-8424 *
See also references of WO0118236A1 *
SHI W ET AL: "Induction of a senescent-like phenotype does not confer the ability of bovine immortal cells to support the development of nuclear transfer embryos", BIOLOGY OF REPRODUCTION, SOCIETY FOR THE STUDY OF REPRODUCTION, CHAMPAIGN, IL, US, vol. 69, no. 1, 1 July 2003 (2003-07-01), pages 301 - 309, XP002504953, ISSN: 0006-3363, [retrieved on 20030319], DOI: 10.1095/BIOLREPROD.102.012112 *
SHIELS P G ET AL: "Analysis of telomere lengths in cloned sheep.", NATURE. ENGLAND 27 MAY 1999, vol. 399, no. 6734, 27 May 1999 (1999-05-27), pages 316 - 317, XP002233924, ISSN: 0028-0836 *
SUHR S.T. ET AL: "Telomere Dynamics in Human Cells Reprogrammed to Pluripotency", PLOS ONE, vol. 4, no. 12, December 2009 (2009-12-01), ISSN: 1932-6203 *
THOMSON J.A. ET AL: "Embryonic stem cell lines derived from human blastocysts.", SCIENCE (NEW YORK, N.Y.) 6 NOV 1998 LNKD- PUBMED:9804556, vol. 282, no. 5391, 6 November 1998 (1998-11-06), pages 1145 - 1147, ISSN: 0036-8075 *
THOMSON J.A. ET AL: "Isolation of a primate embryonic stem cell line.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 15 AUG 1995 LNKD- PUBMED:7544005, vol. 92, no. 17, 15 August 1995 (1995-08-15), pages 7844 - 7848, ISSN: 0027-8424 *
TIAN X.C. ET AL: "Normal telomere lengths found in cloned cattle.", NATURE GENETICS NOV 2000 LNKD- PUBMED:11062462, vol. 26, no. 3, November 2000 (2000-11-01), pages 272 - 273, ISSN: 1061-4036 *
WAKAYAMA T. ET AL: "Cloning of mice to six generations", NATURE, vol. 407, 21 September 2000 (2000-09-21), pages 318 - 319 *
WRIGHT W.E. ET AL: "Telomerase activity in human germline and embryonic tissues and cells.", DEVELOPMENTAL GENETICS 1996 LNKD- PUBMED:8934879, vol. 18, no. 2, 1996, pages 173 - 179, ISSN: 0192-253X *
YANG X. ET AL: "Cloning adult animals - what is the genetic age of the clones?", CLONING 2000 LNKD- PUBMED:16218848, vol. 2, no. 3, 2000, pages 123 - 128, ISSN: 1520-4553 *
YANG X. ET AL: "Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning", NATURE GENETICS, vol. 39, no. 3, March 2007 (2007-03-01), pages 295 - 302, ISSN: 1061-4036 *
ZAKHARTCHENKO V ET AL: "Effects of serum starvation and re-cloning on the efficiency of nuclear transfer using bovine fetal fibroblasts", JOURNAL OF REPRODUCTION AND FERTILITY, JOURNALS OF REPRODUCTION AND FERTILITY LTD, GB, vol. 115, no. 2, March 1999 (1999-03-01), pages 325 - 331, XP001037005, ISSN: 0022-4251 *
ZAWADA ET AL: "Somatic cell cloned transgenic bovine neurons for transplantation in Parkinsonian rats", NATURE MEDICINE, NATURE PUBLISHING, CO, US, vol. 4, no. 5, 1 May 1998 (1998-05-01), pages 569 - 574, XP002092260, ISSN: 1078-8956 *

Also Published As

Publication number Publication date
WO2001018236A1 (en) 2001-03-15
NZ531844A (en) 2005-08-26
IL148457A (en) 2013-01-31
JP2003508079A (ja) 2003-03-04
CA2383790A1 (en) 2001-03-15
AU7350800A (en) 2001-04-10
CN1377424A (zh) 2002-10-30
CA2383790C (en) 2016-11-22
MXPA02002443A (es) 2004-07-16
IL148457A0 (en) 2002-09-12
BR0013844A (pt) 2002-05-14
EP1214443A1 (en) 2002-06-19

Similar Documents

Publication Publication Date Title
EP1214443A4 (en) RESTORATION OF THE TELOMER AND EXTENSION OF THE CELL LIFETIME IN CLONED ANIMALS FROM SENESCENT SOMATIC CELLS
DE19782089T1 (de) Verfahren zum Nachweisen von Punktmutationen in DNA unter Verwendung von Fluoreszenzenergieübergang
DE60140804D1 (de) Neue nukleinsäuresonden und verfahren zum testen von nukleinsäuren unter deren verwendung
DE69703798D1 (de) Verfahren zum elektrobeschichten nichtleitender materialien
DE69502421D1 (de) Verfahren zum Nachweis von DNS-Strängen unter Verwendung von im Infrarot fluoreszierenden Labeln
DE69801719D1 (de) Verfahren zum Befüllen von Batterien mit Elektrolyt
ATE319842T1 (de) Gene und verfahren zur bekampfung von nematoden
DE69520330D1 (de) Verfahren zum Nachweis von spezifischen Nukleinsäuresequenzen
DE69836901D1 (de) Verfahren zum Hinzufügen von Kontext zu Kommunikationen
DE69839944D1 (de) Verfahren zum feintuning von strukturkanten mithilfe einer optischen halbtonmaske
DE69535428D1 (de) Verfahren zum Auffinden von differentiel exprimierte Gene
DE69430054D1 (de) Verfahren zum einbetten von tierkulturzellen
ATA7752002A (de) Verfahren zur nachbehandlung einer photovoltaischen zelle
DE69617982D1 (de) Ein dünnes, mit klein-durchmesser-stahlkorden verstärktes reifengewebe und verfahren zum überlappungsspleissen von gewebe
DE602004026111D1 (de) Verfahren zum testen von nukleinsäuren unter verwendung davon sowie dafür zu verwendende nukleinsäuresonde
DE69636835D1 (de) Verfahren zur verwendung der nukleotid-integrase zur spaltung von dna und zum einbau von nukleinsäuren
DE69737648D1 (de) Verfahren zum effizienten Berechnen von Leistungssummenübersprechverlust
DE69836116D1 (de) Verfahren zum Unterscheiden von Platten mit ähnlicher Reflektivität
DE50000454D1 (de) Verfahren zum betreiben einer brennstoffzellenanlage und brennstoffzellenanlage
DE69801498D1 (de) Verbessertes verfahren zum mischen von metallsalzen und kautschuk
DE69826458D1 (de) Verfahren zum sequenzierung von dna
DE69730979D1 (de) Verfahren zum entwerfen von luftreifen
DE19882409T1 (de) Verfahren zum Entfernen Stickoxiden unter Verwendung von Naturmanganerzen
DE69915916D1 (de) Verfahren zum Ausrichten einer Fahrzeugaufhängung
DE59814133D1 (de) Verfahren zum übergeben von Betriebsparametern von einer Zentrale an ein örtlich begrenztes drahtloses Telekommunikationssystem und entsprechendes drahtloses Telekommunikationssytstem

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20020408

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

RIN1 Information on inventor provided before grant (corrected)

Inventor name: CIBELLI, JOSE

Inventor name: WEST, MICHAEL

Inventor name: LANZA, ROBERT, L.

A4 Supplementary search report drawn up and despatched

Effective date: 20030715

17Q First examination report despatched

Effective date: 20050324

17Q First examination report despatched

Effective date: 20050324

REG Reference to a national code

Ref country code: DE

Ref legal event code: R003

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 20111117