EP1212341A4 - Polynukleotide und davon kodierte polypeptide die entfernte homologe von heparanase sind - Google Patents

Polynukleotide und davon kodierte polypeptide die entfernte homologe von heparanase sind

Info

Publication number
EP1212341A4
EP1212341A4 EP00937164A EP00937164A EP1212341A4 EP 1212341 A4 EP1212341 A4 EP 1212341A4 EP 00937164 A EP00937164 A EP 00937164A EP 00937164 A EP00937164 A EP 00937164A EP 1212341 A4 EP1212341 A4 EP 1212341A4
Authority
EP
European Patent Office
Prior art keywords
heparanase
polynucleotides
polypeptides encoded
distantly homologous
distantly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00937164A
Other languages
English (en)
French (fr)
Other versions
EP1212341A1 (de
Inventor
Iris Pecker
Israel Michal
Hanan Itzhaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Insight Biopharmaceuticals Ltd
Original Assignee
Insight Strategy and Marketing Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Insight Strategy and Marketing Ltd filed Critical Insight Strategy and Marketing Ltd
Publication of EP1212341A1 publication Critical patent/EP1212341A1/de
Publication of EP1212341A4 publication Critical patent/EP1212341A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01166—Heparanase (3.2.1.166)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
EP00937164A 1999-06-25 2000-06-19 Polynukleotide und davon kodierte polypeptide die entfernte homologe von heparanase sind Withdrawn EP1212341A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14080199P 1999-06-25 1999-06-25
US140801P 1999-06-25
PCT/IL2000/000358 WO2001000643A2 (en) 1999-06-25 2000-06-19 Polynucleotides and polypeptides encoded thereby distantly homologous to heparanase

Publications (2)

Publication Number Publication Date
EP1212341A1 EP1212341A1 (de) 2002-06-12
EP1212341A4 true EP1212341A4 (de) 2002-11-27

Family

ID=22492846

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00937164A Withdrawn EP1212341A4 (de) 1999-06-25 2000-06-19 Polynukleotide und davon kodierte polypeptide die entfernte homologe von heparanase sind

Country Status (12)

Country Link
EP (1) EP1212341A4 (de)
JP (1) JP2003503070A (de)
KR (1) KR20020028906A (de)
CN (1) CN1370178A (de)
AU (1) AU777343B2 (de)
CA (1) CA2377498A1 (de)
HU (1) HUP0300901A2 (de)
IL (1) IL146527A0 (de)
MX (1) MXPA01011708A (de)
NO (1) NO20015526L (de)
PL (1) PL362599A1 (de)
WO (1) WO2001000643A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2878600A (en) * 1999-03-01 2000-09-21 Hadasit Medical Research Services & Development Company Ltd Polynucleotide encoding a polypeptide having heparanase activity and expression of same in genetically modified cells
US6872558B1 (en) * 1999-09-23 2005-03-29 Merck Patent Gmbh Heparanase-2 a member of the heparanase protein family
ES2269211T3 (es) * 1999-12-22 2007-04-01 Ucb, S.A. Enzimas homologas de la heparanasa humana y sus variantes de empalme.
SK8882002A3 (en) * 1999-12-23 2002-11-06 Schering Ag Human heparanase-related polypeptide and nucleic acid
GB0014447D0 (en) * 2000-06-13 2000-08-09 Smithkline Beecham Plc Novel compounds
AU2001287610A1 (en) * 2000-07-12 2002-01-21 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw A second human heparanase, and splice variants thereof, with a predominant expression in skeletal muscle, heart and pancreas
IL162276A0 (en) * 2004-06-01 2005-11-20 Hadasit Med Res Service Nucleic acid molecules as heparanase potent inhibitors, compositions and methods of use thereof
FI20085308A0 (fi) * 2008-04-11 2008-04-11 Polysackaridforskning I Uppsal Heparanaasittomia ihmiskuntaan kuulumattomia nisäkkäitä
JP5622451B2 (ja) * 2010-06-21 2014-11-12 小川香料株式会社 茶エキス
JP6321506B2 (ja) * 2014-09-22 2018-05-09 株式会社 資生堂 ヘパラナーゼ阻害剤による美白方法及び美白効果を有する物質の評価方法
CN108884462B (zh) * 2016-01-26 2022-11-25 日产化学株式会社 单链寡核苷酸

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999021975A1 (en) * 1997-10-28 1999-05-06 The Australian National University Isolated nucleic acid molecule encoding mammalian endoglucuronidase and uses therefor
WO1999057153A1 (en) * 1998-05-01 1999-11-11 Insight Strategy & Marketing Ltd. Heparanase specific molecular probes and their use in research and medical applications

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999021975A1 (en) * 1997-10-28 1999-05-06 The Australian National University Isolated nucleic acid molecule encoding mammalian endoglucuronidase and uses therefor
WO1999057153A1 (en) * 1998-05-01 1999-11-11 Insight Strategy & Marketing Ltd. Heparanase specific molecular probes and their use in research and medical applications

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 28 October 1998 (1998-10-28), "qg97h02.x1 Soares_NFL_T_GBC_S1 Homo sapiens cDNA clone IMAGE:1843155 3', mRNA sequence", XP002215097, Database accession no. AI222323 *
VLODAVSKY I ET AL: "Expression of heparanase by platelets and circulating cells of the immune system: Possible involvement in diapedesis and extravasation.", INVASION & METASTASIS, vol. 12, no. 2, 1992, pages 112 - 127, XP001106180, ISSN: 0251-1789 *

Also Published As

Publication number Publication date
NO20015526D0 (no) 2001-11-12
CN1370178A (zh) 2002-09-18
JP2003503070A (ja) 2003-01-28
CA2377498A1 (en) 2001-01-04
AU777343B2 (en) 2004-10-14
WO2001000643A2 (en) 2001-01-04
AU5244800A (en) 2001-01-31
EP1212341A1 (de) 2002-06-12
WO2001000643A3 (en) 2005-02-24
HUP0300901A2 (hu) 2003-07-28
MXPA01011708A (es) 2003-09-10
NO20015526L (no) 2001-12-18
KR20020028906A (ko) 2002-04-17
IL146527A0 (en) 2002-07-25
PL362599A1 (en) 2004-11-02

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Legal Events

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Effective date: 20051116

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Owner name: INSIGHT BIOPHARMACEUTICALS LTD.

STAA Information on the status of an ep patent application or granted ep patent

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Effective date: 20061031