EP1210095B1 - Withania somnifera zusammensetzung - Google Patents
Withania somnifera zusammensetzung Download PDFInfo
- Publication number
- EP1210095B1 EP1210095B1 EP00982710A EP00982710A EP1210095B1 EP 1210095 B1 EP1210095 B1 EP 1210095B1 EP 00982710 A EP00982710 A EP 00982710A EP 00982710 A EP00982710 A EP 00982710A EP 1210095 B1 EP1210095 B1 EP 1210095B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- extract
- composition
- withania somnifera
- oligosaccharides
- aqueous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 49
- 240000004482 Withania somnifera Species 0.000 title claims abstract description 37
- 235000001978 Withania somnifera Nutrition 0.000 title claims abstract description 32
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- 239000000284 extract Substances 0.000 claims abstract description 43
- DBRXOUCRJQVYJQ-CKNDUULBSA-N withaferin A Chemical compound C([C@@H]1[C@H]([C@@H]2[C@]3(CC[C@@H]4[C@@]5(C)C(=O)C=C[C@H](O)[C@@]65O[C@@H]6C[C@H]4[C@@H]3CC2)C)C)C(C)=C(CO)C(=O)O1 DBRXOUCRJQVYJQ-CKNDUULBSA-N 0.000 claims abstract description 27
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- 229960005055 sodium ascorbate Drugs 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Medicines Containing Plant Substances (AREA)
Claims (9)
- Extraktzusammensetzung von Withania somnifera, zu erhalten durch Extraktion mit einem 1:1 wässrigem-alkoholischen Lösemittel, wobei der Extrakt in Form eines stabilen Kraut-Pulvers vorliegt, das für den Anwender bei Einnahme in einer Dosierung von 200 bis 800 mg/Tag eine kognitive Wirkund und Lernfähigkeit vermittelt, welche Zusammensetzung in Gewichtsprozent aufweist: (a) mindestens 3% Withanolid-Glykoside einschließlich Sitoindoside; (b) mindestens 3% Oligosaccharide und (c) weniger als 5% freies Withaferin A (Aglykon), wobei das Gewichtsverhältnis von (a):(c) 75...95:25...5 beträgt und das - Gewichtsverhältnis von (a):(b) 40...60:60...40 beträgt.
- Zusammensetzung nach Anspruch 1, worin die Oligosaccharide eine relative Molekülmasse von weniger als 2.000 haben.
- Zusammensetzung nach Anspruch 2 einschließlich Asche, worin die Extraktzusammensetzung zu mindestens 90% wasserlöslich ist, der Aschegehalt maximal 8% beträgt und der Feuchtigkeitsgehalt maximal 5% (Gewicht/Gewicht) beträgt.
- Zusammensetzung nach Anspruch 1, worin (a) 3 bis 8% und (b) 3 bis 8% beträgt.
- Verfahren zur Herstellung der Extraktzusammensetzung nach Anspruch 1, welches Verfahren umfasst: Bereitstellen (a) Wurzelstock der Pflanze Withania somnifera, der ein Alter von etwa 1 bis 2 Jahren hat; (b) unmittelbares Extrahieren des Wurzelstockes mit einem wässrig-alkoholischen Lösemittel (c) Einengen des Extraktes unter Vakuum; (d) Behandeln des Rückstandes mit einem apolaren organischen Lösemittel, um daraus freie Withanolid A-Aglkyone zu entfernen; (e) Vakuumtrocknen des unlöslichen Rückstandes einer solchen Behandlung unterhalb von 60°C, um einen trockenen Feststoff bereitzustellen; und (f) Pulverisieren des Feststoffes unter Bedingungen geregelter Temperatur und Feuchtigkeit, um das gewünschte Pulverprodukt zu erhalten.
- Verfahren nach Anspruch 5, bei welchem wässrig-alkoholische Lösemittel Wasser-Methanol oder Wasser-Ethanol ist und das organische Lösemittel Chloroform oder Ethylacetat ist.
- Produkt zur pharmazeutischen Verwendung oder zur Verwendung als Nährmittel, worin die Extraktzusammensetzung nach einem der vorgenannten Ansprüche 1 bis 4 einbezogen ist, in einer Darreichungsform, die geeignet ist für die orale Verabreichung mit einer Verabreichungsmenge von 200 bis 800 mg/Tag wahlweise einschließlich Arzneimittelträger, die für eine solche orale Verabreichung geeignet sind, wobei die Darreichungsform eine Tablette ist, eine Kapsel oder ein Elixier oder eine Suspension.
- Produkt nach Anspruch 7, welches eine Vitamintablette ist.
- Verwendung einer Zusammensetzung nach einem der Ansprüche 1 bis 4 in einem Verfahren zum Herstellen eines pharmazeutischen Produktes zur Immunstimulation.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US351890 | 1999-07-13 | ||
| US09/351,890 US6153198A (en) | 1999-07-13 | 1999-07-13 | Withania somnifera composition |
| PCT/US2000/018851 WO2001003715A1 (en) | 1999-07-13 | 2000-07-11 | Withania somnifera composition |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EP1210095A1 EP1210095A1 (de) | 2002-06-05 |
| EP1210095A4 EP1210095A4 (de) | 2003-05-02 |
| EP1210095B1 true EP1210095B1 (de) | 2006-09-06 |
Family
ID=23382856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP00982710A Expired - Lifetime EP1210095B1 (de) | 1999-07-13 | 2000-07-11 | Withania somnifera zusammensetzung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6153198A (de) |
| EP (1) | EP1210095B1 (de) |
| AT (1) | ATE338562T1 (de) |
| AU (1) | AU2318601A (de) |
| CA (1) | CA2374929A1 (de) |
| DE (1) | DE60030568T2 (de) |
| ES (1) | ES2272343T3 (de) |
| WO (1) | WO2001003715A1 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040033273A1 (en) * | 2001-02-14 | 2004-02-19 | Ayurcore, Inc. | Withasol and methods of use |
| WO2003068251A1 (en) * | 2002-02-14 | 2003-08-21 | Dalmia Centre For Research And Development | Herbal formulation for treating attention defienciency disorder (add/adht) and process for preparation |
| WO2003079812A1 (en) * | 2002-03-25 | 2003-10-02 | Council Of Scientific And Industrial Research | Herbal nutraceuticals and a process for preparing the same |
| NL1021288C2 (nl) * | 2002-08-16 | 2004-02-17 | Exenta B V | Kruidenextract, alsmede de toepassing van een dergelijk kruidenextract. |
| US6713092B1 (en) * | 2002-12-03 | 2004-03-30 | Natreon Inc. | Withania Somnifera composition, method for obtaining same and pharmaceutical, nutritional and personal care formulations thereof |
| US7282593B2 (en) * | 2003-09-11 | 2007-10-16 | Board Of Trustees Of Michigan State University | Withanamide and withanolide compositions and method of use thereof |
| WO2005077392A1 (en) * | 2004-01-19 | 2005-08-25 | Ranbaxy Laboratories Limited | Herbal formulation comprising extracts of withania, tinospora and picrorhiza as a pediatric tonic |
| WO2005092356A1 (en) * | 2004-03-25 | 2005-10-06 | Palaniappan Meenakshisundaram | A novel herbal composition for treating hiv/aids and fungal infections secondary to hiv |
| US20050266100A1 (en) * | 2004-03-30 | 2005-12-01 | Council Of Scientific And Industrial Research Rafi Marg | Process isolation of withaferin-A from plant materials and products therefrom |
| US7108870B2 (en) * | 2004-04-13 | 2006-09-19 | Council Of Scientific & Industrial Research | Process for isolation of withaferin-A from plant materials and products therefrom |
| WO2006067796A1 (en) * | 2004-12-24 | 2006-06-29 | Council Of Scientific And Industrial Research | Herbal formulation as memory enhacher in alzheimer condition |
| US7250181B2 (en) * | 2005-01-19 | 2007-07-31 | Natreon, Inc. | Polyherbal compositions and methods for treating viral infections |
| US20070036873A1 (en) * | 2005-07-27 | 2007-02-15 | Shibnath Ghosal | Method of treatment or management of stress |
| US20090311367A1 (en) * | 2008-06-17 | 2009-12-17 | Perry Stephen C | Dietary Supplement |
| US20120070521A1 (en) * | 2009-05-22 | 2012-03-22 | Bio-Ved Pharmaceuticals, PVT., Ltd. | Method of extraction from withania somnifera and one or more fractions containing pharmacologically active ingredients obtained therefrom |
| WO2011056549A1 (en) * | 2009-10-27 | 2011-05-12 | Access Business Group International Llc | Molecular targets and dietary modulators of exercise-induced muscle damage |
| WO2012020422A1 (en) * | 2010-08-09 | 2012-02-16 | Interdisciplinary School Of Indian System Of Medicine | A novel herbal formulation advocated for the prevention and management of coronary heart disease |
| WO2012160569A1 (en) | 2011-05-23 | 2012-11-29 | Gufic Biosciences Limited | "process for extraction of ashwagandha (withania somnifera) roots" |
| US8597697B2 (en) | 2011-06-24 | 2013-12-03 | Nutragenesis, Llc | Composition of beta-glucan and ashwagandha |
| US9084800B2 (en) | 2011-11-07 | 2015-07-21 | Natreon, Inc. | Indolealkylamino-withasteroid conjugates and method of use |
| US8609162B2 (en) * | 2012-10-04 | 2013-12-17 | Invivo Beverages Llc | Integrated neuromodulation system for mood enhancement of a living human subject |
| WO2016051424A1 (en) * | 2014-09-29 | 2016-04-07 | Council Of Scientific & Industrial Research | A formulation useful for delivery of neuro protecting agent |
| CA3002624A1 (en) | 2015-10-22 | 2017-04-27 | Benny Antony | A process to enhance the bioactivity of ashwagandha extracts |
| US9987323B2 (en) | 2015-10-22 | 2018-06-05 | Benny Antony | Process to enhance the bioactivity of Ashwagandha extracts |
| EP3585400A4 (de) | 2017-02-27 | 2020-12-30 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Antipsychotische zusammensetzung und behandlungsverfahren |
| DE102021200826A1 (de) | 2021-01-29 | 2022-08-04 | Eva Süßmann | Zusammensetzung |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5494668A (en) * | 1994-07-11 | 1996-02-27 | Patwardhan; Bhushan | Method of treating musculoskeletal disease and a novel composition therefor |
| US5888514A (en) * | 1997-05-23 | 1999-03-30 | Weisman; Bernard | Natural composition for treating bone or joint inflammation |
-
1999
- 1999-07-13 US US09/351,890 patent/US6153198A/en not_active Expired - Lifetime
-
2000
- 2000-07-11 AU AU23186/01A patent/AU2318601A/en not_active Abandoned
- 2000-07-11 ES ES00982710T patent/ES2272343T3/es not_active Expired - Lifetime
- 2000-07-11 AT AT00982710T patent/ATE338562T1/de not_active IP Right Cessation
- 2000-07-11 CA CA002374929A patent/CA2374929A1/en not_active Abandoned
- 2000-07-11 WO PCT/US2000/018851 patent/WO2001003715A1/en active IP Right Grant
- 2000-07-11 DE DE60030568T patent/DE60030568T2/de not_active Expired - Lifetime
- 2000-07-11 EP EP00982710A patent/EP1210095B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE60030568D1 (de) | 2006-10-19 |
| ATE338562T1 (de) | 2006-09-15 |
| ES2272343T3 (es) | 2007-05-01 |
| WO2001003715A1 (en) | 2001-01-18 |
| EP1210095A4 (de) | 2003-05-02 |
| CA2374929A1 (en) | 2001-01-18 |
| US6153198A (en) | 2000-11-28 |
| AU2318601A (en) | 2001-01-30 |
| EP1210095A1 (de) | 2002-06-05 |
| DE60030568T2 (de) | 2007-09-13 |
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