EP1210038A1 - Segment de colonne vertebrale - Google Patents

Segment de colonne vertebrale

Info

Publication number
EP1210038A1
EP1210038A1 EP00962218A EP00962218A EP1210038A1 EP 1210038 A1 EP1210038 A1 EP 1210038A1 EP 00962218 A EP00962218 A EP 00962218A EP 00962218 A EP00962218 A EP 00962218A EP 1210038 A1 EP1210038 A1 EP 1210038A1
Authority
EP
European Patent Office
Prior art keywords
vertebral body
vertebral
spine
intervertebral disc
segment according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP00962218A
Other languages
German (de)
English (en)
Inventor
Peter Metz-Stavenhagen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19944682A external-priority patent/DE19944682C2/de
Application filed by Individual filed Critical Individual
Publication of EP1210038A1 publication Critical patent/EP1210038A1/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064—Surgical staples, i.e. penetrating the tissue
    • A61B17/0642—Surgical staples, i.e. penetrating the tissue for bones, e.g. for osteosynthesis or connecting tendon to bone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064—Surgical staples, i.e. penetrating the tissue
    • A61B2017/0647—Surgical staples, i.e. penetrating the tissue having one single leg, e.g. tacks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064—Surgical staples, i.e. penetrating the tissue
    • A61B2017/0647—Surgical staples, i.e. penetrating the tissue having one single leg, e.g. tacks
    • A61B2017/0648—Surgical staples, i.e. penetrating the tissue having one single leg, e.g. tacks threaded, e.g. tacks with a screw thread
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30756—Cartilage endoprostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
    • A61F2002/2839—Bone plugs or bone graft dowels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
    • A61F2002/30677—Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
    • A61F2002/4649—Bone graft or bone dowel harvest sites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00359—Bone or bony tissue
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S606/00—Surgery
    • Y10S606/907—Composed of particular material or coated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S606/00—Surgery
    • Y10S606/907—Composed of particular material or coated
    • Y10S606/909—Bone

Definitions

  • the present invention relates to a spinal segment for implantation in a human spine.
  • intervertebral disc also called an intervertebral disc
  • Intervertebral disc is not possible because the intervertebral disc, which mainly consists of cartilage, cannot regenerate.
  • DE 1 96 32 404 A1 discloses a transplantable cartilage tissue consisting of a new extracellular matrix (ECM) which, due to genetic engineering, releases matrix molecules, immunosuppressive or cell-differentiating factors, the cartilage tissue being surrounded by a semipermeable membrane.
  • ECM extracellular matrix
  • This cartilage tissue is suitable for joints, but not as a replacement for intervertebral discs.
  • the object of the present invention is to create a spine segment for implantation in a human spine which is available in sufficient quantity.
  • the invention proposes to form a spinal segment for implantation in a human spine, which comprises a vertebral body insert and / or an intervertebral disc with the associated upper and / or lower vertebral body fragment and / or a vertebral arch, in particular with the various extensions the intervertebral disc is formed from a genetically manipulated animal intervertebral disc, or wherein the Vertebral body insert, the vertebral body fragments, the vertebral arch and / or the extensions are formed from genetically manipulated animal bones.
  • the present invention is based on the knowledge that a transgenic animal intervertebral disc and / or a transgenic animal bone, in particular from pigs or sheep, is in principle also suitable for implantation in a human spine.
  • Intervertebral discs and associated vertebral bodies can be created.
  • transgenic animal intervertebral discs or vertebral body inserts or vertebral body fragments or vertebral arches or their extensions such that these elements have the same blood group, in particular the same blood subgroup, the same tissue structure and / or the same bone structure as the human Have a spine in which they are to be implanted.
  • the intervertebral disc of both the human and the animal spine is closely overgrown with the vertebral body below and above and is only held in the correct position by this. It has been found that an intervertebral disc that has been severed once does not easily grow again on the vertebral body, which is why it is advantageous to combine the intervertebral disc with the one below and / or to implant the overlying vertebral body or at least with a corresponding vertebral body fragment. So that this implant is quickly brought to the desired size and / or grows rapidly in the human spine, the growth of the animal bone is accelerated by means of a nutrient solution and / or a growing factor.
  • This nutrient solution can, for example, be hydroxyapatite (also called coral lime), which supports bone formation positively.
  • the diseased and worn intervertebral disc is advantageously removed by smoothly cutting through the adjacent vertebral bodies. This also facilitates the design of the implant.
  • the implant is fixed by inserting a clamp into the two parts of the severed vertebral body.
  • a clip is advantageously U-shaped and so sharp that the clip can be pressed with its free ends into the two parts of the respective vertebral body.
  • the intervertebral disc is replaced by an exclusively genetically manipulated vertebral body insert.
  • the screw is so long and thin executed that the screw extends through the vertebral arch through into the vertebral body; this also enables reliable fixation of the implant.
  • the screw opens into a counterpart with a corresponding internal thread, which is inserted into the vertebral body from the opposite side and which is held in a form-fitting manner in the vertebral body.
  • Figure 1 is a side view of a human spine with the first, exploded spine segments.
  • 2 shows a side view of a human spine with further, exploded spine segments;
  • 3 shows a rear view of a human spine with a spine segment according to the invention and with clips shown in an explosive manner;
  • 4 shows a side view of a human spine with a further, exploded spine segment;
  • Fig. 5 is a rear view of a human spine with a spine segment according to the invention and with explosively shown brackets.
  • the human spine 10 shown in FIG. 1 comprises a number of vertebrae 1 2, between each of which an intervertebral disc or intervertebral disc 1 4 is arranged.
  • a diseased or damaged intervertebral disc 14 can be replaced by a new intervertebral disc by separating a vertebral body fragment 1 6 of the vertebral body 18 together with the intervertebral disc 1 4 from the vertebra 1 2 located above and below the intervertebral disc 14.
  • the spinal segment 20 separated from the spine 1 0 comprises a damaged intervertebral disc 1 4 and the adjacent vertebral fragments 1 6 of the vertebral body 1 8 of the vertebra 1 2.
  • the vertebral fragment 1 6 is clean by a straight cut separated out.
  • a new spinal segment 20, which has the same dimensions and contours, is then inserted into the free space created in this way.
  • This new spinal column segment 20 is composed of a genetically manipulated animal intervertebral disc 22 and corresponding, genetically manipulated vertebral body fragments 24.
  • This genetically manipulated spinal column segment 20 is taken, for example, from a genetically manipulated pig or a genetically manipulated sheep.
  • the animals are genetically manipulated in such a way that they have the same blood group, and in particular the same blood subgroup, the same tissue structure and the same bone structure as the human spine to be treated.
  • a correspondingly genetically manipulated pig or sheep increases the acceptance of the implanted spinal segment 20 in the human spine 10, since the human body will not reject this implant as a foreign body.
  • the spinal column segment 26 extends over the entire vertebral body 18 of the vertebrae 12, the vertebral arch together with the extensions 28 from the vertebral body 1 8 is separated. This allows the entire size of the intervertebral disc 1 4 to be re-implanted.
  • the vertebral body segment 20 shown in FIG. 1 or the vertebral arch with its extensions 30 shown in FIG. 1 is screwed to a corresponding, healthy part of the vertebra 1 2 with a bio screw or with a biopin 32.
  • the vertebral body segment 26 shown in FIG. 2 is penetrated in the region of its vertebral body fragments 34 by sleeve-like counterparts 36, into whose internal thread screws 38 passed through the vertebral arch 28 can be screwed.
  • the vertebral body segment 26 is joined together without damaging the nerve strands running in the spine 10.
  • Vertebral body 1 8 connected. As can be seen better in detail in FIG. 3, the clamp 40 is pressed with its sharp-edged leg into the vertebral body fragment 40 of the implant, while the other, likewise sharp-edged leg of the U-shaped clamp 40 is pressed into the vertebral body 1 8 of the vertebra 1 2 is pressed in and thus holds the vertebral body segment 26 to be implanted in the desired position. Distributed over the circumference of the vertebral body 1 8, one, two or three such clips 40 can be used as required.
  • the spine fragment to be obtained from the respective pig or sheep may not have the size required for the human spine 10. That is why the spine segment taken from the respective animal is brought to the desired size in the laboratory with growth accelerators.
  • growth accelerators can be, for example, coral lime (hydroxelapatite) and / or a growing factor.
  • the vertebral fragment Coral lime is applied and soaked with a growing factor, for example a transforming growing factor or a bone morpho genetic protein. After the accelerated growth of the bone (vertebral body fragment) has resulted in an implant of sufficient size, it can then be implanted in the spine.
  • the embodiment shown in FIGS. 4 and 5 differs from the embodiment shown in FIGS. 1 and 3 in that the spinal column segment is a vertebral body insert 42 which is formed exclusively from genetically manipulated bones, in the manner described above or by the Brackets 40 is used in place of the removed intervertebral disc.
  • This vertebral body insert 42 grows together with the neighboring vertebral fragments 18 in a known manner. This part of the spine becomes stiff. If necessary, further bone parts can be attached, in particular screwed, to this vertebral body insert 42.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne un segment de colonne vertébrale à implanter dans la colonne vertébrale (10), chez l'homme, qui comprend un élément rapporté de corps de vertèbre (42) et/ou un disque intervertébral (22) avec le fragment de corps de vertèbre supérieur et/ou inférieur (28, 34) qui s'y rapporte, notamment avec les prolongements divers. Le disque intervertébral (22) comprend un disque intervertébral animal génétiquement manipulé. L'élément rapporté du corps de vertèbre, les fragments de corps de vertèbre (24, 34), l'arc vertébral (28, 30) et/ou les prolongements sont obtenus à partir d'os animaux génétiquement manipulés.
EP00962218A 1999-08-20 2000-08-16 Segment de colonne vertebrale Ceased EP1210038A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19939530 1999-08-20
DE19939530 1999-08-20
DE19944682A DE19944682C2 (de) 1999-08-20 1999-09-17 Wirbelsäulensegment
DE19944682 1999-09-17
PCT/DE2000/002760 WO2001013826A1 (fr) 1999-08-20 2000-08-16 Segment de colonne vertebrale

Publications (1)

Publication Number Publication Date
EP1210038A1 true EP1210038A1 (fr) 2002-06-05

Family

ID=26054669

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00962218A Ceased EP1210038A1 (fr) 1999-08-20 2000-08-16 Segment de colonne vertebrale

Country Status (7)

Country Link
US (1) US6719798B2 (fr)
EP (1) EP1210038A1 (fr)
JP (1) JP2003507124A (fr)
AU (1) AU7403100A (fr)
CA (1) CA2376129A1 (fr)
DE (1) DE10082436D2 (fr)
WO (1) WO2001013826A1 (fr)

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EP1781369A2 (fr) * 2004-07-22 2007-05-09 Cytyc Corporation Systeme de positionnement de tissus et methodes pour les utiliser en radiotherapie
CN1795833A (zh) * 2004-12-23 2006-07-05 杨守恒 颈椎椎体间固定融合垫具
CN1795832A (zh) * 2004-12-23 2006-07-05 杨守恒 腰椎椎体间固定融合器
FR2885514B1 (fr) * 2005-05-12 2007-07-06 Medicrea Internat Sa Materiel d'osteosynthese vertebral
JP2009506843A (ja) 2005-09-01 2009-02-19 スパイナル カネティックス， インコーポレイテッド 人工椎間板
US7731753B2 (en) 2005-09-01 2010-06-08 Spinal Kinetics, Inc. Prosthetic intervertebral discs
US20070050032A1 (en) 2005-09-01 2007-03-01 Spinal Kinetics, Inc. Prosthetic intervertebral discs
US20070239278A1 (en) * 2006-04-06 2007-10-11 Sdgi Holdings, Inc. Intervertebral prosthetic devices and methods
US9968460B2 (en) 2013-03-15 2018-05-15 Medsmart Innovation Inc. Dynamic spinal segment replacement
CN110916735B (zh) * 2019-11-26 2021-09-03 杭州电子科技大学 一种可降解生物活性螺钉及其制造方法
USD998147S1 (en) 2021-06-21 2023-09-05 Pressio, Inc. Boring tool handle
USD996480S1 (en) 2021-06-21 2023-08-22 Pressio Inc. Boring tool
US11311289B1 (en) * 2021-06-21 2022-04-26 Pressio Inc. Compression and fixation systems and processes for using the same
USD977640S1 (en) 2021-06-21 2023-02-07 Pressio, Inc. Staple instrument
WO2023240284A1 (fr) * 2022-06-10 2023-12-14 Novum Coral, Inc. Procédés d'augmentation de la croissance de corail à l'aide d'une biocéramique

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AU7403100A (en) 2001-03-19
US20020107575A1 (en) 2002-08-08
CA2376129A1 (fr) 2001-03-01
WO2001013826A1 (fr) 2001-03-01
DE10082436D2 (de) 2003-02-20
US6719798B2 (en) 2004-04-13
JP2003507124A (ja) 2003-02-25

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