EP1146909A1 - Traitement du cancer par restauration de la fonction pp32 - Google Patents

Traitement du cancer par restauration de la fonction pp32

Info

Publication number
EP1146909A1
EP1146909A1 EP00905923A EP00905923A EP1146909A1 EP 1146909 A1 EP1146909 A1 EP 1146909A1 EP 00905923 A EP00905923 A EP 00905923A EP 00905923 A EP00905923 A EP 00905923A EP 1146909 A1 EP1146909 A1 EP 1146909A1
Authority
EP
European Patent Office
Prior art keywords
cells
sequence
expression
normal
sequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00905923A
Other languages
German (de)
English (en)
Other versions
EP1146909A4 (fr
Inventor
Gary R. Pasternack
Jining Bai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Publication of EP1146909A1 publication Critical patent/EP1146909A1/fr
Publication of EP1146909A4 publication Critical patent/EP1146909A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)

Abstract

La présente invention concerne le traitement ou la prévention de cancer par restauration de la fonction pp32 de cellules dépourvues d'activité ou d'expression pp32 normale. Le procédé assure cette restauration de pp32, par transfection des cellules avec de l'ADN exprimant la pp32 normale, par administration d'un inducteur de l'activité pp32, et/ou inhibition d'une phosphatase nucléaire inhibée par pp32.
EP00905923A 1999-02-03 2000-02-03 Traitement du cancer par restauration de la fonction pp32 Withdrawn EP1146909A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11866799P 1999-02-03 1999-02-03
US118667P 1999-02-03
PCT/US2000/002656 WO2000045852A1 (fr) 1999-02-03 2000-02-03 Traitement du cancer par restauration de la fonction pp32

Publications (2)

Publication Number Publication Date
EP1146909A1 true EP1146909A1 (fr) 2001-10-24
EP1146909A4 EP1146909A4 (fr) 2004-12-29

Family

ID=22380017

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00905923A Withdrawn EP1146909A4 (fr) 1999-02-03 2000-02-03 Traitement du cancer par restauration de la fonction pp32

Country Status (5)

Country Link
EP (1) EP1146909A4 (fr)
JP (1) JP2002536346A (fr)
AU (1) AU2751900A (fr)
CA (1) CA2361838A1 (fr)
WO (1) WO2000045852A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008077311A1 (fr) * 2006-12-26 2008-07-03 Institute Of Radiation Medicine, Academy Of Military Medical Sciences, Pla Hépatopoïétine et son utilisation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5726018A (en) * 1990-08-01 1998-03-10 Johns Hopkins University Nucleic acid based assays to detect a novel mammalian protein associated with uncontrolled cell division
WO1999029906A2 (fr) * 1997-12-12 1999-06-17 The Johns Hopkins University Famille de genes possedant une activite de modulation de la transformation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5700821A (en) * 1996-07-30 1997-12-23 University Of Pittsburgh Phosphatase inhibitors and methods of use thereof
US5916749A (en) * 1996-12-13 1999-06-29 Incyte Pharmaceuticals, Inc. Human phosphatase inhibitor protein

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5726018A (en) * 1990-08-01 1998-03-10 Johns Hopkins University Nucleic acid based assays to detect a novel mammalian protein associated with uncontrolled cell division
WO1999029906A2 (fr) * 1997-12-12 1999-06-17 The Johns Hopkins University Famille de genes possedant une activite de modulation de la transformation

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BRODY JONATHAN R ET AL: "Identification of sequences required for inhibition of oncogene-mediated transformation by pp32" JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 29, 16 July 1999 (1999-07-16), pages 20053-20055, XP002303700 ISSN: 0021-9258 *
CHEN T-H ET AL: "STRUCTURE OF PP32, AN ACIDIC NUCLEAR PROTEIN WHICH INHIBITS ONCOGENE-INDUCED FORMATION OF TRANSFORMED FOCI" MOLECULAR BIOLOGY OF THE CELL, BETHESDA, MD, US, vol. 7, December 1996 (1996-12), pages 2045-2056, XP002929314 ISSN: 1059-1524 *
DADKOL S S ET AL: "MODULATION OF ONCOGENIC POTENTIAL BY ALTERNATIVE GENE USE IN HUMAN PROSTATE CANCER" NATURE MEDICINE, NATURE PUBLISHING, CO, US, vol. 5, no. 3, March 1999 (1999-03), pages 275-279, XP002929315 ISSN: 1078-8956 *
DATABASE BIOSIS [Online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1993, WALENSKY LOREN D ET AL: "A novel M-r 32000 nuclear phosphoprotein is selectively expressed in cells competent for self-renewal" XP002303701 Database accession no. PREV199396138528 & CANCER RESEARCH, vol. 53, no. 19, 1993, pages 4720-4726, ISSN: 0008-5472 *
DATABASE EMBL 'HOMO SAPIENS CANDIDATE TUMOR SUPPRESSOR PP32R1. 8 January 1998 (1998-01-08), ....: XP002106403 Database accession no. AF008216 *
DATABASE EMBL 'HUMAN PP32 PSEUDOGENE, PARTIAL CDS.' 3 April 1997 (1997-04-03), XP002106402 Database accession no. U71084 *
KOCHEVAR G J ET AL: "The structure of a gene encoding PP32R1, a new transforming protein" MOLECULAR BIOLOGY OF THE CELL, vol. 8, no. SUPPL., November 1997 (1997-11), page 137A, XP008037808 & 37TH ANNUAL MEETING OF THE AMERICAN SOCIETY FOR CELL BIOLOGY; WASHINGTON, D.C., USA; DECEMBER 13-17, 1997 ISSN: 1059-1524 *
LI M ET AL: "MOLECULAR IDENTIFICATION OF I PP2A, A NOVEL POTENT HEAT-STABLE INHIBITOR PROTEIN OF PROTEIN PHOSPHATASE 2A" BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, vol. 35, no. 22, 1996, pages 6998-7002, XP002929316 ISSN: 0006-2960 *
See also references of WO0045852A1 *

Also Published As

Publication number Publication date
JP2002536346A (ja) 2002-10-29
CA2361838A1 (fr) 2000-08-10
WO2000045852A1 (fr) 2000-08-10
EP1146909A4 (fr) 2004-12-29
AU2751900A (en) 2000-08-25

Similar Documents

Publication Publication Date Title
US6740523B2 (en) 14-3-3σ arrests the cell cycle
JP2006512908A (ja) 腫瘍抑制遺伝子および組成物ならびにその作製法および使用法
US6020127A (en) Neuronal apoptosis inhibitor protein, gene sequence and mutations causative of spinal muscular atrophy
CA2554380C (fr) Gene mecp2e1
WO2006105486A2 (fr) Nouveau gene suppresseur de tumeur, et compositions et procedes de fabrication et d'utilisation de ce gene
CA2104964A1 (fr) Diagnostic et traitement du cancer
JP2002525081A (ja) 低酸素により調節される遺伝子転写に特徴的な配列
US6930175B1 (en) Gene family with transformation modulating activity
AU684930B2 (en) DNA encoding CAI resistance proteins and uses thereof
EP1045926B1 (fr) Famille de genes possedant une activite de modulation de la transformation
KR20090060212A (ko) 암의 검출 및 치료를 위한 조성물 및 방법
AU2003204082B2 (en) Gene family with transformation modulating activity
EP1146909A1 (fr) Traitement du cancer par restauration de la fonction pp32
AU767718B2 (en) Novel mutations in the (FREAC3) gene for diagnosis and prognosis of glaucoma and anterior segment dysgenesis
AU2005200892A1 (en) Method of treating cancer by restoration of PP32 function
WO2000034466A1 (fr) Traitement du cancer du col de l'uterus
US7462447B2 (en) Methods for evaluating susceptibility to a bone homeostasis disorder
WO2001018037A2 (fr) Proteine induite par p53 avec un domaine de mort pouvant favoriser l'apoptose
US6790936B1 (en) CAI resistance proteins and uses thereof
US20030108915A1 (en) Glioblastoma multiforme associated protein GliTEN
EP1001966A1 (fr) Gene de senescence et son utilisation dans le traitement du cancer et d'autres maladies
JP2006504407A (ja) 血管障害、異常脂質血症および関連疾患の治療用の新規治療標的
WO2003087357A2 (fr) Marqueur retinien d'acides nucleiques
WO2003035890A2 (fr) Proteine gliten associee au glioblastome multiforme

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20010810

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

A4 Supplementary search report drawn up and despatched

Effective date: 20041112

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20060519