EP1137412A4 - Substituierte stickstoffhaltige heterocyclische verbindungen und deren therapeutische verwendung - Google Patents

Substituierte stickstoffhaltige heterocyclische verbindungen und deren therapeutische verwendung

Info

Publication number
EP1137412A4
EP1137412A4 EP99965946A EP99965946A EP1137412A4 EP 1137412 A4 EP1137412 A4 EP 1137412A4 EP 99965946 A EP99965946 A EP 99965946A EP 99965946 A EP99965946 A EP 99965946A EP 1137412 A4 EP1137412 A4 EP 1137412A4
Authority
EP
European Patent Office
Prior art keywords
heterocyclic compounds
therapeutic uses
substituted nitrogen
nitrogen heterocyclic
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99965946A
Other languages
English (en)
French (fr)
Other versions
EP1137412A2 (de
Inventor
Jacob Szmuszkovicz
Ciaran M Regan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University College Dublin
American Biogenetic Sciences Inc
Original Assignee
University College Dublin
American Biogenetic Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University College Dublin, American Biogenetic Sciences Inc filed Critical University College Dublin
Publication of EP1137412A2 publication Critical patent/EP1137412A2/de
Publication of EP1137412A4 publication Critical patent/EP1137412A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP99965946A 1998-12-11 1999-12-01 Substituierte stickstoffhaltige heterocyclische verbindungen und deren therapeutische verwendung Withdrawn EP1137412A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11183998P 1998-12-11 1998-12-11
US111839P 1998-12-11
PCT/US1999/028374 WO2000033788A2 (en) 1998-12-11 1999-12-01 Substituted nitrogen heterocyclic compounds and therapeutic uses thereof

Publications (2)

Publication Number Publication Date
EP1137412A2 EP1137412A2 (de) 2001-10-04
EP1137412A4 true EP1137412A4 (de) 2002-04-03

Family

ID=22340712

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99965946A Withdrawn EP1137412A4 (de) 1998-12-11 1999-12-01 Substituierte stickstoffhaltige heterocyclische verbindungen und deren therapeutische verwendung

Country Status (4)

Country Link
EP (1) EP1137412A4 (de)
AU (1) AU2160900A (de)
CA (1) CA2355296A1 (de)
WO (1) WO2000033788A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2819511A1 (fr) * 2001-01-18 2002-07-19 Servier Lab Nouveaux composes azepane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2004002483A1 (en) * 2002-06-27 2004-01-08 Actelion Pharmaceuticals Ltd Substituted 3- and 4- aminomethylpiperidines for use as beta-secretase in the treatment of alzheimer’s disease
WO2005108359A1 (en) * 2004-05-06 2005-11-17 Pfizer Inc. Novel compounds of proline and morpholine derivatives
JP2006143667A (ja) * 2004-11-22 2006-06-08 Ube Ind Ltd ピペコリン酸アミド誘導体及び抗菌剤
PL2049478T3 (pl) 2006-07-06 2012-09-28 Glaxo Group Ltd Podstawione N-fenylometylo 5-okso-prolino-2-amidy jako antagoniści receptora P2X7 oraz sposoby ich zastosowania
WO2009074518A1 (en) * 2007-12-12 2009-06-18 Glaxo Group Limited Combinations of prolinamide p2x7 modulators with further therapeutic agents
US8629157B2 (en) 2009-01-05 2014-01-14 Boehringer Ingelheim International Gmbh Pyrrolidine compounds which modulate the CB2 receptor
CN110240557B (zh) 2018-03-08 2023-05-09 广东东阳光药业有限公司 吡咯烷酰胺衍生物及其用途

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508880A (en) * 1974-12-18 1978-04-26 Synthelabo 2-methoxy-benzamide derivatives
EP0296560A2 (de) * 1987-06-22 1988-12-28 Eisai Co., Ltd. 1,4-Substituierte Piperidine als Acetylcholinesterase Inhibitoren und ihre Verwendung zur Behandlung von Alzheimer's Erkrankung
JPH02104568A (ja) * 1988-06-22 1990-04-17 Yoshitomi Pharmaceut Ind Ltd 神経成長因子産生促進作用剤
US5053548A (en) * 1989-02-08 1991-10-01 Otsuka Pharmaceutical Company, Ltd. Biphenyl derivative composition for nerve cell degeneration repairing or protective agent and process for preparing a phenyl derivative contained in the composition
US5446147A (en) * 1992-04-03 1995-08-29 Trustees Of The University Of Pennsylvania Fluorinated and iodinated dopamine agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993021186A1 (en) * 1992-04-13 1993-10-28 Fujisawa Pharmaceutical Co., Ltd. Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508880A (en) * 1974-12-18 1978-04-26 Synthelabo 2-methoxy-benzamide derivatives
EP0296560A2 (de) * 1987-06-22 1988-12-28 Eisai Co., Ltd. 1,4-Substituierte Piperidine als Acetylcholinesterase Inhibitoren und ihre Verwendung zur Behandlung von Alzheimer's Erkrankung
JPH02104568A (ja) * 1988-06-22 1990-04-17 Yoshitomi Pharmaceut Ind Ltd 神経成長因子産生促進作用剤
US5053548A (en) * 1989-02-08 1991-10-01 Otsuka Pharmaceutical Company, Ltd. Biphenyl derivative composition for nerve cell degeneration repairing or protective agent and process for preparing a phenyl derivative contained in the composition
US5446147A (en) * 1992-04-03 1995-08-29 Trustees Of The University Of Pennsylvania Fluorinated and iodinated dopamine agents

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BARLOCCO, D. ET AL: "Monocyclic Analogues of the m-Opioid Antagonist 3,8-Diazabicyclo-[3.2.1]octanes: Synthesis Modeling and Activities", TETRAHEDRON, vol. 51, no. 42, 1995, pages 11547 - 11556, XP001026295 *
CHANDRAKUMAR, N. S. ET AL.: "Preparation and Opioid Activity of Analogues of the Analgesic Dipeptide 2,6-Dimethyl-L-tyrosyl-N-(3-phenylpropyl)-D-alaninamide", J. MED. CHEM., vol. 35, no. 2, 1992, pages 223 - 233, XP001026297 *
COREY, E. J.; LINK, J. O.: "A Catalytic Enantioselective Synthesis of Denopamine, a Useful Drug for Congestive Heart Failure", J. ORG. CHEM, vol. 56, no. 1, 1991, pages 442 - 444, XP001055628 *
DEHMLOW, E. V. ET AL: "Revisiting optically active quaternary derivatives made from prolinol as phase transfer catalysts", TETRAHEDRON ASYMMETRY, vol. 9, no. 13, 1998, pages 2235 - 2244, XP004131368 *
MORIE, T. ET AL: "Ring Expansion of Nitrogen-containing Chloromethylheteroalicycles via Aziridinium Intermediates", J. CHEM. SOC. PERKIN TRANS. I, vol. 18, 1994, pages 2565 - 2570, XP001055909 *
O'NEIL I A ET AL: "The Highly Stereoselective Formation of Pipecolic Acid N-Oxide and Related Derivatives", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 38, no. 32, 1 August 1997 (1997-08-01), pages 5731 - 5734, XP004085745, ISSN: 0040-4039 *
PATENT ABSTRACTS OF JAPAN vol. 014, no. 310 (C - 0736) 4 July 1990 (1990-07-04) *
See also references of WO0033788A3 *
ZHAO S ET AL: "SYNTHESES OF 1,2-DIAMINO AND 1,2-AMINOALCOHOL DERIVATIVES IN THE PIPERIDINE AND PYRROLDINE SERIES AS ANTI-AMNESIC AGENTS", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 7, 1999, pages 1647 - 1654, XP002928878, ISSN: 0968-0896 *

Also Published As

Publication number Publication date
WO2000033788A2 (en) 2000-06-15
EP1137412A2 (de) 2001-10-04
AU2160900A (en) 2000-06-26
WO2000033788A3 (en) 2000-10-19
CA2355296A1 (en) 2000-06-15

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