GB1508880A - 2-methoxy-benzamide derivatives - Google Patents

2-methoxy-benzamide derivatives

Info

Publication number
GB1508880A
GB1508880A GB51635/75A GB5163575A GB1508880A GB 1508880 A GB1508880 A GB 1508880A GB 51635/75 A GB51635/75 A GB 51635/75A GB 5163575 A GB5163575 A GB 5163575A GB 1508880 A GB1508880 A GB 1508880A
Authority
GB
United Kingdom
Prior art keywords
carbon atoms
alkyl
hydrogen
dec
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB51635/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7441718A external-priority patent/FR2294698A1/en
Priority claimed from FR7531334A external-priority patent/FR2327771A2/en
Priority claimed from FR7534570A external-priority patent/FR2331345A2/en
Application filed by Synthelabo SA filed Critical Synthelabo SA
Publication of GB1508880A publication Critical patent/GB1508880A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6

Abstract

1508880 2 - Methoxybenzamides SYNTHELABO 17 Dec 1975 [18 Dec 1974 14 Oct 1975 13 Nov 1975] 51635/75 Heading C2C Novel compounds (I) (including salts, racemates and isomers thereof) in which n is 1 or 2; R 1 represents a cycloalkylalkyl radical of formula (OH 2 ) m -CH-A-, a phenylalkyl radical of formula (in which m is an integer from 2 to 5, A is a linear or branched chain alkylene chain of 1 to 4 carbon atoms, and R 4 is hydrogen, halogen, trifluoromethyl, or alkyl or alkoxy of 1 to 3 carbon atoms), CNCH 2 -CH 2 -, CH=C-CH 2 -, or R 2 is chlorine, SO 2 R 5 (in which R 5 is alkyl of 1 to 4 carbon atoms), or SO 2 NR 6 R 7 (in which, R 6 and R 7 , which are identical or different, represent, independently of one another, hydrogen or alkyl of 1 to 4 carbon atoms); and R 3 is hydrogen or alkyl of 1 to 4 carbon atoms; are made by acylating amines (III) which are themselves obtained by reducing nitro compounds (IV) which are in turn prepared by reacting ketones (V) with MeNO 2 . Pharmaceutical preparations useful in treating nervous and psychosomatic disorders contain (I) as active ingredient. Administration is orally, parenterally or rectally.
GB51635/75A 1974-12-18 1975-12-17 2-methoxy-benzamide derivatives Expired GB1508880A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR7441718A FR2294698A1 (en) 1974-12-18 1974-12-18 NEW DERIVATIVES OF 2-METHOXY BENZAMIDES SUBSTITUTE, THEIR SALTS, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM
FR7531334A FR2327771A2 (en) 1975-10-14 1975-10-14 N-Heterocyclylmethy 12-methoxy-benzamides - useful for treating nervous and psychosomatic disorders (BE170676)
FR7534570A FR2331345A2 (en) 1975-11-13 1975-11-13 N-Heterocyclylmethy 12-methoxy-benzamides - useful for treating nervous and psychosomatic disorders (BE170676)

Publications (1)

Publication Number Publication Date
GB1508880A true GB1508880A (en) 1978-04-26

Family

ID=27250393

Family Applications (1)

Application Number Title Priority Date Filing Date
GB51635/75A Expired GB1508880A (en) 1974-12-18 1975-12-17 2-methoxy-benzamide derivatives

Country Status (17)

Country Link
AT (1) AT353782B (en)
AU (1) AU497616B2 (en)
CA (1) CA1039731A (en)
CH (1) CH612668A5 (en)
DE (1) DE2556457C3 (en)
DK (1) DK574075A (en)
ES (2) ES443563A1 (en)
FI (1) FI753586A (en)
GB (1) GB1508880A (en)
GR (1) GR59205B (en)
IE (1) IE42210B1 (en)
IL (1) IL48678A (en)
LU (1) LU74026A1 (en)
MX (1) MX3180E (en)
NL (1) NL168219C (en)
NO (1) NO143625C (en)
SE (1) SE412908B (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4789683A (en) * 1981-03-11 1988-12-06 Astra Lakemedel Aktiebolag Benzamido-derivatives
US4937260A (en) * 1982-09-09 1990-06-26 Astra Lakemedal Aktiebolag Benzamido-derivatives
EP0623601A1 (en) * 1993-04-30 1994-11-09 Shell Internationale Researchmaatschappij B.V. N-(3-Fluorobenzyl)heterocyclic derivatives and their use as pesticides
TR27478A (en) * 1993-04-30 1995-06-07 Shell Int Research New n-benzyl heterocyclic compounds with biocide activity.
EP1137412A2 (en) * 1998-12-11 2001-10-04 American Biogenetic Sciences, Inc. Substituted nitrogen heterocyclic compounds and therapeutic uses thereof

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4189495A (en) * 1974-09-17 1980-02-19 Synthelabo 2-Methoxy-benzamide derivatives
US4097481A (en) * 1976-11-08 1978-06-27 Riker Laboratories, Inc. Tertiary amide derivatives of pyrrolidine and piperidine
FR2415099A1 (en) * 1978-01-20 1979-08-17 Ile De France NEW DERIVATIVES OF 4-AMINO-5-ALKYLSULFONYL ORTHO-ANISAMIDES, THEIR METHODS OF PREPARATION AND THEIR APPLICATION AS PSYCHOTROPES
FR2440946A2 (en) * 1978-01-20 1980-06-06 Ile De France NOVEL SUBSTITUTED HETEROCYCLIC BENZAMIDES, PROCESSES FOR THEIR PREPARATION AND THEIR APPLICATION AS BEHAVIOR MODIFIERS
SE411118B (en) * 1978-03-23 1979-12-03 Astra Laekemedel Ab A PROCEDURE FOR THE PREPARATION OF 2,6-DIALCOXIBENSAMIDES WITH THERAPENTIC PROPERTIES

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4789683A (en) * 1981-03-11 1988-12-06 Astra Lakemedel Aktiebolag Benzamido-derivatives
US4937260A (en) * 1982-09-09 1990-06-26 Astra Lakemedal Aktiebolag Benzamido-derivatives
EP0623601A1 (en) * 1993-04-30 1994-11-09 Shell Internationale Researchmaatschappij B.V. N-(3-Fluorobenzyl)heterocyclic derivatives and their use as pesticides
TR27478A (en) * 1993-04-30 1995-06-07 Shell Int Research New n-benzyl heterocyclic compounds with biocide activity.
EP1137412A2 (en) * 1998-12-11 2001-10-04 American Biogenetic Sciences, Inc. Substituted nitrogen heterocyclic compounds and therapeutic uses thereof
EP1137412A4 (en) * 1998-12-11 2002-04-03 American Biogenetic Sciences Substituted nitrogen heterocyclic compounds and therapeutic uses thereof

Also Published As

Publication number Publication date
NO754284L (en) 1976-06-21
ES443563A1 (en) 1977-08-16
AU8764675A (en) 1977-06-23
DE2556457B2 (en) 1980-05-29
ES457872A1 (en) 1978-03-01
NL168219C (en) 1982-03-16
NL168219B (en) 1981-10-16
IL48678A (en) 1979-01-31
DE2556457C3 (en) 1981-02-12
DK574075A (en) 1976-06-19
CA1039731A (en) 1978-10-03
NO143625C (en) 1981-03-18
IL48678A0 (en) 1976-02-29
MX3180E (en) 1980-06-11
SE412908B (en) 1980-03-24
NO143625B (en) 1980-12-08
SE7514143L (en) 1976-06-21
IE42210L (en) 1976-06-18
AT353782B (en) 1979-12-10
AU497616B2 (en) 1978-12-21
FI753586A (en) 1976-06-19
IE42210B1 (en) 1980-06-18
ATA959075A (en) 1979-05-15
GR59205B (en) 1977-11-26
CH612668A5 (en) 1979-08-15
NL7514620A (en) 1976-06-22
LU74026A1 (en) 1976-11-11
DE2556457A1 (en) 1976-06-24

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee