EP1124646B1 - Reservoir provided with a device for closing and/or filling and sprayer for dispensing a fluid product comprising same - Google Patents

Reservoir provided with a device for closing and/or filling and sprayer for dispensing a fluid product comprising same Download PDF

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Publication number
EP1124646B1
EP1124646B1 EP19990950824 EP99950824A EP1124646B1 EP 1124646 B1 EP1124646 B1 EP 1124646B1 EP 19990950824 EP19990950824 EP 19990950824 EP 99950824 A EP99950824 A EP 99950824A EP 1124646 B1 EP1124646 B1 EP 1124646B1
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EP
European Patent Office
Prior art keywords
reservoir
filling
closure element
fluid
closure
Prior art date
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Expired - Lifetime
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EP19990950824
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German (de)
French (fr)
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EP1124646A1 (en
Inventor
Giuseppe Stradella
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Aptar France SAS
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Valois SAS
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/02Membranes or pistons acting on the contents inside the container, e.g. follower pistons
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005Components or details
    • B05B11/0062Outlet valves actuated by the pressure of the fluid to be sprayed

Definitions

  • the present invention relates to a device for closing and / or filling a sprayer tank as well as a fluid sprayer comprising a such tank.
  • the present invention is particularly suitable for use in a spraying of liquid, in particular in the field of pharmacy.
  • a first problem concerns the stability and the product contamination. Indeed, during his period of storage, a liquid product tends to evaporate and / or could be contaminated by external agents such as bacteria, or even oxidized by oxygen. To avoid all evaporation, tight closure and use of non-permeable materials for the constituent parts tanks are required. To avoid any contamination, it is important to minimize the number of different materials in contact with the product fluid, and these materials should also be inert vis-à-vis the product. Materials suitable for fulfill these two requirements include for example the glass for the tank, and special rubbers not interacting with the liquid product for the sealing device (s).
  • the product by example the vaccine
  • the product will only be available for a few months before use (2 to 3 months), and filling million devices will have to be realized in a time very short.
  • a rubber stopper which also serves pump piston, is pierced at the time of actuation by a hollow needle which is connected to the nozzle of spraying the device.
  • This solution allows solve the problem of stability and contamination of the product contained in the tank, since it only uses glass and rubber, but it does not overcome the problem of filling after assembly of the tank. Indeed, the tank must be filled separately before assembly end of the device.
  • no precompression is not provided by this system since the resistance of the rubber at the needle penetration is very limited.
  • the piercing provided by the needle can in some cases remove small particles of rubber that could clog the spray or be ejected into the user's nasal cavity.
  • the closure is carried out in a way relatively simple, the opening of the device is complex, requires several components, and is difficult to handle, especially due to the presence of a needle.
  • US-3,841,329 discloses a syringe comprising a plug adapted to form the piston of dispensing when the syringe is actuated.
  • This piston-cap has a slot which opens when the syringe is activated.
  • the object of the present invention is to provide a system closing and / or filling for a tank intended for use in a device for spraying, which does not have the disadvantages supra.
  • the present invention aims to provide a tank with a simple and effective closure which is opened by the pressure that is created inside the tank at the time of actuation, without the need for a complex opening system that removes or pierces or removes parts of components.
  • the present invention also aims to provide a such a tank which is simple and inexpensive to manufacture and to assemble.
  • the present invention also aims to provide a closing and / or filling system which allows the use of a minimum of materials in contact with the product contained in the tank, and in particular glass for the tank and a rubber with inert characteristics towards the product for the closing element.
  • the present invention also aims to provide a closing and filling system for a tank, which can be used as a liquid inlet for a quick and easy filling, filling can in particular be carried out before the complete final assembly of the fluid dispenser incorporating said tank.
  • the present invention also aims to provide a opening and / or filling system that opens, to allow the expulsion of the liquid, only if a sufficiently high and predetermined pressure is created during actuation a tank, so that the product is expelled with some precompression. This is particularly advantageous as part of a system spray.
  • the present invention also aims to tank comprising a closure and filling which simultaneously fulfills all requirements above, i.e. it ensures the stability of the product contained in the tank, which it avoids contamination of this product by chemical interaction, that it allows a quick and simple filling of the tank, especially after final assembly of the device, and that expels the product with precompression be predetermined.
  • said central part of said at least a sealing element has a closed axial bore on one side by said bottom wall made of a material elastically deformable, and said slot opens by deformation of said bottom wall in response to a predetermined minimum pressure exerted on it.
  • said closure element is adapted to receive the end of an actuator of a fluid sprayer, said member actuator comprising a product expulsion channel and said end of the actuator being concave so that under the effect of a predetermined pressure created inside of the reservoir upon actuation of said member actuation, said bottom wall of the element shutter is deformed towards the outside of the tank, the interior of said concave end, to achieve opening the slot and dispensing with precompression of the product contained in the through said expulsion channel.
  • the actuating member comprises a shoulder cooperating with a support zone of said element shutter to transmit the actuating force and moving said closure member into said reservoir to pre-compress the product contained in the tank.
  • said at least obturation element adapted to receive an arrangement filling tank to fill the tank with the product before or after its assembly in a fluid dispenser.
  • said filling arrangement has a filling tube which, by exerting a certain pressure on said bottom wall, deforms it towards the inside of the tank to cross said open slot.
  • said filling arrangement has a radial flange cooperating with the element shutter and the tank wall so that the pressure exerted by the tube to pass through the slit does not move said closure member within the tank.
  • the closing and / or filling device comprises a first sealing element acting as a plug sealing in the rest position and as piston during product distribution, and a second sealing element acting as a stopper watertight closure and / or as a filling element.
  • a hollow rigid member is disposed in said bore of said second obturation element and is suitable for receiving a filling arrangement of the tank, comprising a filling tube which, in exerting a certain pressure on said bottom wall, deforms it towards the inside of the tank to cross said open slit.
  • said hollow rigid member comprises a radial flange cooperating with the second element shutter and the tank wall so that the pressure exerted by the tube to pass through the slit does not move said second shutter member to inside the tank.
  • the tank further includes a third closure element fixedly arranged between the first and second elements shutter, said third shutter element sealing the tank into two sub-tanks, each sub-tank containing a product different, for example a powder and a liquid, and said second shutter member further acting as piston to mix the two products in one of the sub-tanks.
  • the third obturation element has a hollow rigid member inserted in its bore central, which allows the opening of the slot in the wall of melts under the effect of a minimum pressure created in a sub-tanks, and which prevents this opening under the effect of a pressure created in the other sub-tank.
  • the filling tube of the filling arrangement passes through said slot, it open it so that an opening is formed around said tube, allowing air to escape as and as the reservoir is filled with the product.
  • the present invention also relates to a fluid sprayer comprising a member actuator and a tank.
  • the tank is made of glass and the or the closure element (s) made of a material that is inert with respect to of the product contained in the tank, and said product is finely sprayed with precompression each actuation of the device.
  • FIG. 1 it is shown a first alternative embodiment of the device closure and / or filling for tank according to the present invention.
  • Reservoir 10 whose walls 11 are preferably made of glass, do not comprises in this variant only one opening, closed by a closing device and filling according to the invention.
  • This device closure and / or filling has an element shutter 20 which acts as a stopper sealed in the rest position, shown in FIG. 1.
  • This closure element 20 comprises an annular part 21 whose diameter outside corresponding substantially to the inside diameter of the reservoir 10, and a central part 22 making it possible to seal the tank in position of rest.
  • the central part 22 has a bottom wall 23 which is provided with one or more slots 24 adapted to open under minimal pressure predetermined.
  • the closure element 20 has a bore axial 22 which is closed on one side by said bottom wall 23, and said bottom wall is preferably made of an elastically deformable material.
  • the shutter element 20, as a whole is produced in the same material, which makes it easier to manufacture.
  • the closure element 20 acts as that sealing plug in the rest position (figure 1), as a piston during the distribution of the product (figure 2), and possibly as an element when the tank 10 is filled with the liquid product ( Figures 3a and 3b).
  • the sealing is carried out in the rest position by the bottom wall 23 of the closure element 20, the slot 24 is kept sealed by the pressure exerted by the walls 11 of the reservoir 10 on the annular part 21 and the bottom wall 23 of the element shutter 20.
  • the shutter element further comprises advantageously a radial flange 29 which extends to the outside on the upper edge of the tank 10, to form a stop against any accidental movement of the closure element 20 inside the tank 10.
  • the central bore 22 the closure element 20 is adapted to receive the end 32 of an actuating member 30 of the device dispensing fluid (not shown) by through which the actuating force exerted by the user on said actuator 30 is transmitted to the closure element 20.
  • Said end 32 of the actuating member 30 cooperates with the central bore 22, advantageously with a support zone 28 of said closure element 20, by through a shoulder 38 of the organ actuator 30, to transmit said force actuating.
  • the end 32 of the actuator 30 has a concave shape so that the wall of bottom 23 can deform inside said end concave 32 to allow the opening of the slot 24.
  • the radial flange 29 of the element shutter 20 folds down along the actuating rod 30 under the effect of the force released by the opening of the slot 24 so that the closure element 20 transforms into a sliding piston inside the walls 11 of the reservoir 10, which then forms the pump body.
  • the precompression achieved by the closure element 20 guarantees that the product contained in the tank is expelled from the tank with optimal pressure.
  • the shutter member 20 then acts as piston and is moved to the bottom of the tank 10, to expel the product it contains, through the slot 24 and an expulsion channel provided in the rod actuation 30.
  • the precompression threshold required to deform the bottom wall 23 and open the slot 24 can be determined by choosing a thickness and / or a appropriate geometry of said bottom portion 23.
  • the geometry of the bottom wall 23 is such that it forms a curved surface, notably concave, on the directed side towards the actuating rod 30.
  • This concave shape forms a resistance to deformation which makes it possible to define precisely the pressure threshold needed to the opening of the slot 24.
  • said bottom wall 23 may have a slot longitudinal 24, as shown in FIG. 3b, or two or more slots made for example in the form of cross, or any other appropriate motif.
  • FIGS. 3a and 3b the shutter element 20 of the device of Figures 1 and 2 is shown in position filling.
  • the filling is carried out through the same element shutter 20 which serves as a closure plug in rest position, and piston being dispensed.
  • the filling must generally be carried out before the final assembly of the distribution device fluid product, in which said reservoir will be adapted.
  • the tank is automatically closed as soon as end of filling by closing the slot 24 after removal of the filling tube.
  • an arrangement of filling 40 fits inside the bore central 22 of the closure element 20, said arrangement filling 40 comprising a radial flange part 45 cooperating with the flange 29 of the closure element 20 and the wall 11 of the reservoir 10, as shown in the Figure 3b.
  • the filling arrangement further comprises a filling tube 41 which is supported by the outside on said bottom wall 23 to deform it, open said slot 24 and enter the interior of the tank 10.
  • the radial flange 45 which cooperates with both the closure element 20 and the wall 11 of the tank, avoids during application force on the bottom wall 23 to deform it to allow penetration of the filling tube 41, that said closure element 20 is not moved inside the tank.
  • This first variant of the present invention which has only one shutter element 20 acting at both as a closure cap, piston, and filling element solves all above problems except that it does not allow usually not filling the tank after final assembly of the product distribution device fluid.
  • the present invention advantageously provides a second closure element 120 arranged on the other side of the tank 10 and which acts in as a closure cap and as part of filling to allow filling of the tank, even after it has been assembled in the dispensing or spraying.
  • the shutter element 120 is made similar to the element shutter 20, preferably it is made so identical, i.e. it includes a part annular 121 and a central portion 122, comprising preferably a central bore 122, closed on one side by a deformable bottom wall 123 which incorporates a slot 124 which can open due to force predetermined.
  • a hollow rigid member 130 is disposed in said bore 122 of the element of filling 120.
  • the radial end wall 132 of said hollow rigid member 130 is preferably made of flat way, that is to say it is arranged facing said deformable bottom wall 123 by preventing the latter to deform towards the outside of the reservoir 10 under the effect of pressure created inside said tank.
  • Said closure element 120 therefore acts as sealed closure cap in rest position and during product distribution.
  • the hollow rigid member 130 has a radial flange 135 which cooperates with the radial flange 129 of the element of filling 120 and with the wall 11 of the reservoir 10 of so as to prevent displacement of said element 120 inside the tank 10 when pressure is exerted from the outside on the bottom wall 123, especially during filling.
  • the filling of the reservoir 10 in this second variant embodiment shown in FIGS. 5a and 5b is carried out similarly to filling the tank of the first variant shown on the Figure 3a, with the difference that this filling can be when the tank is already assembled in the fluid dispenser.
  • the filling assembly 140 in particular the tube filling 141 is brought through said rigid member hollow 130 to rest on the bottom wall 123, the deform and pass through slot 124.
  • the element of filling 120 not intended to serve as piston during product dispensing, it can be easily accessible by the filling device itself when the tank is already assembled in the device.
  • the tank 10 is returned relative to the position shown in Figure 4 to allow air to escape through the openings 127 provided around the filling tube 141 in slot 124, and avoid any leakage of liquid through said openings 127.
  • the filling element 120 has been shown on the Figures 4 and 5 in conjunction with an element of filling 20 described previously in the context of the first variant.
  • FIG. 6 there is shown a third variant, adapted more particularly a single dose drug device lyophilized.
  • the reservoir 10 is separated into two sub-tanks 110 and 210 by a third obturation element 220 which is fixedly disposed, via a radial flange portion 229, inside said tank 10.
  • This third closure element 220 is made of similar to the first and second elements shutter 20 and 120, and in particular comprises a part ring 221 inserted tightly inside the reservoir 10 and a central bore 222 comprising a bottom wall 223 provided with a slot 224 adapted to open under the effect of a predetermined pressure.
  • the sub-tank 110 comprises a lyophilized powder
  • the sub-reservoir 210 comprises a liquid solvent for the lyophilized drug.
  • the second closure element 120 arranged in FIG. 6 on the lower side of the tank 10, acts in this variant as a closure cap in the rest position, possibly as part of filling to fill the sub-tank 210 but also as a piston for mixing the lyophilized product and its solvent. The actuation of this device is made in two phases.
  • the liquid contained in the sub-tank 210 is transferred to sub-tank 110 through the slot 224 provided in the bottom wall 223 of the third element shutter 220 by applying pressure in the sub-tank 210 through an element actuator (not shown) acting on the organ rigid hollow 130 of the second closure element 120.
  • Said pressure created in the sub-tank 210 causes the deformation of the bottom wall 223 and the opening of slot 224 so that the liquid solvent is transferred inside the sub-tank 110 via the piston 120.
  • said mixture is expelled through the expulsion channel 31 of the organ actuator 30 by means of the first closure element 20 as described previously with reference to FIGS. 1, 2 and 3.
  • the third filling element 220 has a hollow rigid member 230 inserted in its central bore 222 and the end 232 of which is formed flatly.
  • the bottom wall 223 can deform in the direction of the sub-tank 110 to allow the passage of the solvent during the first phase, but cannot deform in the other direction, during a overpressure created in the sub-tank 110 during the expulsion of the mixture, thus guaranteeing sealing.
  • the rigid member 130 inserted in the central bore 122 of the second closure element 120 advantageously has also an end 132 made in this way to avoid any solvent leakage during the first phase, during which an overpressure is created inside of the sub-tank 210. In this case, the slot 124 cannot open only inward to let a tube pass filling, if necessary.
  • the present invention therefore makes it possible to carry out very simple and inexpensive way a device closure and filling for tank which allows overcome all the disadvantages mentioned above.
  • the tank may have a single closure element but in the preferred embodiment, it has two sealing elements, one at each end of the tank, the first serving as a sealed stopper in the rest position and piston when dispensing the product, and the second acting as a watertight closure cap and as a filler, allowing in particular fill the tank after assembly in a any suitable device or sprayer.
  • the present invention has been described with reference to three variant embodiments, but it is understood that these are not limiting, those skilled in the art can make various modifications without leaving the scope of the present invention as defined in appended claims.
  • the invention is not not limited to single dose devices.
  • stop means or the like may be provided for expel the product contained in the tank in two or more actuations of the device.

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Description

La présente invention concerne un dispositif de fermeture et/ou de remplissage d'un réservoir de pulvérisateur ainsi qu'un pulvérisateur de produit fluide comportant un tel réservoir. La présente invention est particulièrement adaptée pour être utilisée dans un dispositif de pulvérisation de liquide, notamment dans le domaine de la pharmacie.The present invention relates to a device for closing and / or filling a sprayer tank as well as a fluid sprayer comprising a such tank. The present invention is particularly suitable for use in a spraying of liquid, in particular in the field of pharmacy.

Dans le domaine des pulvérisateurs de médicaments, et en particulier dans le cas des dispositifs dans lesquels la pompe est préremplie au moment de l'emballage du dispositif, comme cela est notamment le cas pour certains dispositifs monodoses ou bidoses, il se pose un certain nombre de problèmes qui doivent être résolus.In the field of drug sprayers, and especially in the case of devices in which the pump is pre-filled when packing the device, as is particularly the case for some monodose or bidose devices, there arises a certain number of issues that need to be resolved.

Un premier problème concerne la stabilité et la contamination du produit. En effet, pendant sa période de stockage, un produit liquide a tendance à s'évaporer et/ou pourrait être contaminer par des agents externes tels que des bactéries, ou même oxydés par l'oxygène. Pour éviter toute évaporation, une fermeture étanche et l'utilisation de matériaux non perméables pour les parties constitutives du réservoirs sont nécessaires. Pour éviter toute contamination, il est important de réduire au maximum le nombre de matériaux différents en contact avec le produit fluide, et ces matériaux devraient en outre être inertes vis-à-vis du produit. Des matériaux appropriés pour remplir ces deux exigences comprennent par exemple le verre pour le réservoir, et des caoutchoucs spéciaux n'interagissant pas avec le produit liquide pour le ou les dispositif(s) d'étanchéité.A first problem concerns the stability and the product contamination. Indeed, during his period of storage, a liquid product tends to evaporate and / or could be contaminated by external agents such as bacteria, or even oxidized by oxygen. To avoid all evaporation, tight closure and use of non-permeable materials for the constituent parts tanks are required. To avoid any contamination, it is important to minimize the number of different materials in contact with the product fluid, and these materials should also be inert vis-à-vis the product. Materials suitable for fulfill these two requirements include for example the glass for the tank, and special rubbers not interacting with the liquid product for the sealing device (s).

Un autre problème qui se pose concerne le remplissage. En effet, l'industrie pharmaceutique nécessite en général des dispositifs qui doivent être faciles à remplir et qui sont, si possible, capables d'être complètement assemblés avant le processus de remplissage du médicament. En effet, la manipulation du médicament est de manière évidente l'étape la plus critique d'un point de vue des problèmes pouvant se poser à cause de l'environnement ambiant, notamment le risque de contamination du produit. Il est donc important de disposer non seulement d'une machine de remplissage appropriée, mais surtout de protéger l'ensemble du processus de remplissage et d'assemblage de manière efficace, ce qui peut s'avérer très complexe et donc également très coûteux. D'autre part, la possibilité de disposer d'un dispositif complètement préassemblé avant son remplissage va devenir de plus en plus importante, notamment dans le cas des pulvérisateurs monodoses ou bidoses destinés à la future utilisation de vaccins contre la grippe. En effet, dans un tel cas, le produit, par exemple le vaccin, ne sera disponible que quelques mois avant son utilisation (2 à 3 mois), et le remplissage de millions de dispositifs devra être réalisé dans un temps très court. Il serait dans ce cas très avantageux de n'avoir plus qu'à remplir le réservoir d'un dispositif déjà complètement assemblé, l'assemblage pouvant avoir eu lieu à tout moment et sans contrainte de délai à respecter.Another problem that arises concerns filling. Indeed, the pharmaceutical industry generally requires devices that should be easy to fill and that are, if possible, capable of being fully assembled before the drug filling process. Indeed, handling the drug is obvious the most critical step from a problem perspective may arise due to the surrounding environment, including the risk of product contamination. It is therefore important to have not only a proper filling, but above all to protect the whole filling and assembly process of effectively, which can be very complex and therefore also very expensive. On the other hand, the possibility have a device completely preassembled before its filling will become more and more important, especially in the case of single-dose sprayers or bidoses for the future use of vaccines against influenza. Indeed, in such a case, the product, by example the vaccine, will only be available for a few months before use (2 to 3 months), and filling million devices will have to be realized in a time very short. In this case, it would be very advantageous to just have to fill the tank with a device already completely assembled, the assembly may have had place at any time and without time constraint at respect.

Encore un autre problème qui se pose concerne la précompression. En effet, dans l'utilisation de pulvérisateurs, la qualité du spray et la taille des particules dépendent de la pression fournie au liquide au moment de son expulsion. Afin de rendre les dispositifs moins dépendants de la force d'actionnement fournie par l'utilisateur, il est préféré de prévoir un système capable de fournir une précompression suffisante au liquide avant son expulsion.Yet another problem which arises concerns the precompression. Indeed, in the use of sprayers, the quality of the spray and the size of particles depend on the pressure supplied to the liquid at time of his expulsion. In order to make the devices less dependent on the actuating force provided by the user, it is preferred to provide a system capable of providing sufficient precompression to the liquid before it is expelled.

A l'heure actuelle, la technologie disponible ne permet pas de résoudre tous les problèmes, ni de remplir toutes les exigences mentionnés ci-dessus, et seules des solutions partielles et complexes sont disponibles dans l'état de la technique.At present, the available technology does not not solve all the problems, nor to fill all of the above requirements, and only partial and complex solutions are available in the state of the art.

Ainsi, il a été proposé des dispositifs dans lesquels une membrane de forme, de matériau ou de type quelconque est fixée sur l'ouverture du réservoir, ladite membrane étant destinée à être cassée ou déchirée par un dispositif approprié au moment de l'actionnement du pulvérisateur. Cette solution permet de résoudre le problème de la stabilité du produit contenu dans le récipient mais présente les inconvénients d'être relativement coûteuse, puisque l'opération d'assemblage de la membrane sur le réservoir est assez complexe. De plus, le remplissage est nécessairement réalisé avant assemblage du réservoir dans le dispositif, et la fixation de la membrane nécessite des matières, telles que des matières plastiques, pour souder ou coller la membrane, qui pourraient causer des problèmes liés à la contamination du produit. En outre, aucune précompression n'est fournie par ce type de système de fermeture.Thus, devices have been proposed in which a membrane of any shape, material or type is fixed on the opening of the tank, said membrane being intended to be broken or torn by a device appropriate when the sprayer is operated. This solution solves the problem of stability of the product contained in the container but has the disadvantages of being relatively expensive, since the assembly operation of the membrane on the tank is quite complex. In addition, the filling is necessarily carried out before assembly of the tank in the device, and fixing the membrane requires materials, such as plastics, for welding or stick the membrane, which could cause problems related to product contamination. Furthermore, none precompression is only provided by this type of closing.

Dans une autre solution divulguée par le document FR-2 684 304, un bouchon en caoutchouc, qui sert également de piston de pompe, est percé au moment de l'actionnement par une aiguille creuse qui est reliée à la buse de pulvérisation du dispositif. Cette solution permet de résoudre le problème de la stabilité et de la contamination du produit contenu dans le réservoir, puisqu'elle n'utilise que du verre et du caoutchouc, mais elle ne permet pas de surmonter le problème lié au remplissage après assemblage du réservoir. En effet, le réservoir doit être rempli séparément avant l'assemblage final du dispositif. D'autre part, aucune précompression n'est fournie par ce système puisque la résistance du caoutchouc à la pénétration de l'aiguille est très limitée. En outre, le percement prévu par l'aiguille peut dans certains cas retirer des petites particules de caoutchouc qui pourraient obstruer le spray ou alors être éjectées dans le cavité nasale de l'utilisateur. De plus, bien que la fermeture soit réalisée d'une manière relativement simple, l'ouverture du dispositif est complexe, nécessite plusieurs composantes, et est difficile à manipuler, notamment en raison de la présence d'une aiguille.In another solution disclosed by the document FR-2 684 304, a rubber stopper, which also serves pump piston, is pierced at the time of actuation by a hollow needle which is connected to the nozzle of spraying the device. This solution allows solve the problem of stability and contamination of the product contained in the tank, since it only uses glass and rubber, but it does not overcome the problem of filling after assembly of the tank. Indeed, the tank must be filled separately before assembly end of the device. On the other hand, no precompression is not provided by this system since the resistance of the rubber at the needle penetration is very limited. In addition, the piercing provided by the needle can in some cases remove small particles of rubber that could clog the spray or be ejected into the user's nasal cavity. Moreover, although the closure is carried out in a way relatively simple, the opening of the device is complex, requires several components, and is difficult to handle, especially due to the presence of a needle.

Le document US-3 841 329 divulgue une seringue comportant un bouchon adapté à former le piston de distribution lors de l'actionnement de la seringue. Ce piston-bouchon comporte une fente qui s'ouvre lorsque la seringue est actionnée.US-3,841,329 discloses a syringe comprising a plug adapted to form the piston of dispensing when the syringe is actuated. This piston-cap has a slot which opens when the syringe is activated.

La présente invention a pour but de fournir un système de fermeture et/ou de remplissage pour un réservoir destiné à être utilisé dans un dispositif de pulvérisation, qui ne présente pas les inconvénients précités.The object of the present invention is to provide a system closing and / or filling for a tank intended for use in a device for spraying, which does not have the disadvantages supra.

Ainsi, la présente invention a pour but de fournir un réservoir comportant une fermeture simple et efficace qui est ouverte par la pression qui se crée à l'intérieur du réservoir au moment de l'actionnement, sans besoin d'un système d'ouverture complexe qui enlève ou perce ou retire des parties de composantes.Thus, the present invention aims to provide a tank with a simple and effective closure which is opened by the pressure that is created inside the tank at the time of actuation, without the need for a complex opening system that removes or pierces or removes parts of components.

La présente invention a aussi pour but de fournir un tel réservoir qui soit simple et peu coûteux à fabriquer et à assembler.The present invention also aims to provide a such a tank which is simple and inexpensive to manufacture and to assemble.

La présente invention a aussi pour but de fournir un système de fermeture et/ou de remplissage qui permet l'utilisation d'un minimum de matériaux en contact avec le produit contenu dans le réservoir, et notamment du verre pour le réservoir et un caoutchouc présentant des caractéristiques inertes vis-à-vis du produit pour l'élément de fermeture.The present invention also aims to provide a closing and / or filling system which allows the use of a minimum of materials in contact with the product contained in the tank, and in particular glass for the tank and a rubber with inert characteristics towards the product for the closing element.

La présente invention a encore pour but de fournir un système de fermeture et de remplissage pour un réservoir, qui peut être utilisé en tant qu'entrée de liquide pour un remplissage facile et rapide, le remplissage pouvant notamment être réalisé avant l'assemblage final complet du dispositif de distribution de produit fluide incorporant ledit réservoir.The present invention also aims to provide a closing and filling system for a tank, which can be used as a liquid inlet for a quick and easy filling, filling can in particular be carried out before the complete final assembly of the fluid dispenser incorporating said tank.

La présente invention a aussi pour but de fournir un système de fermeture et/ou de remplissage qui s'ouvre, pour permettre l'expulsion du liquide, seulement si une pression suffisamment élevée et prédéterminée est créée pendant l'actionnement un réservoir, de sorte que le produit est expulsé avec une certaine précompression. Ceci est particulièrement avantageux dans le cadre de système de pulvérisation.The present invention also aims to provide a opening and / or filling system that opens, to allow the expulsion of the liquid, only if a sufficiently high and predetermined pressure is created during actuation a tank, so that the product is expelled with some precompression. This is particularly advantageous as part of a system spray.

La présente invention a également pour but un réservoir comportant un dispositif de fermeture et de remplissage qui remplit simultanément toutes les exigences ci-dessus, c'est-à-dire qu'il assure la stabilité du produit contenu dans le réservoir, qu'il évite une contamination de ce produit par interaction chimique, qu'il permet un remplissage rapide et simple du réservoir, notamment après assemblage final du dispositif, et qu'il assure l'expulsion du produit avec une précompression prédéterminable.The present invention also aims to tank comprising a closure and filling which simultaneously fulfills all requirements above, i.e. it ensures the stability of the product contained in the tank, which it avoids contamination of this product by chemical interaction, that it allows a quick and simple filling of the tank, especially after final assembly of the device, and that expels the product with precompression be predetermined.

La présente invention a donc pour objet un réservoir d'un pulvérisateur de produit fluide, ledit réservoir contenant un produit fluide à distribuer et comportant un dispositif de fermeture et/ou de remplissage dudit réservoir, ledit dispositif comportant au moins un élément d'obturation agissant en tant que bouchon de fermeture étanche au repos, ledit au moins un élément d'obturation comprenant :

  • une partie annulaire dont le diamètre extérieur correspond sensiblement au diamètre intérieur du réservoir, ladite partie annulaire étant insérée de manière étanche dans ledit réservoir, et
  • une partie centrale comportant une paroi de fond qui obture de manière étanche ledit réservoir en position de repos,
caractérisé en ce que ladite paroi de fond comporte au moins une fente adaptée à s'ouvrir sous l'effet d'une pression minimale prédéterminée, de telle sorte que le produit est distribué avec une précompression prédéterminée suffisante pour obtenir une bonne pulvérisation du produit, ledit seuil de pression prédéterminé étant défini par la géométrie de ladite paroi de fond et/ou l'épaisseur de ladite paroi de fond et/ou les caractéristiques du matériau de ladite paroi de fond et/ou les dimensions de ladite fente.The present invention therefore relates to a reservoir for a fluid sprayer, said reservoir containing a fluid to be dispensed and comprising a device for closing and / or filling said reservoir, said device comprising at least one sealing element acting as a sealing cap at rest, said at least one closure element comprising:
  • an annular part, the outside diameter of which corresponds substantially to the inside diameter of the tank, said annular part being sealed in said tank, and
  • a central part comprising a bottom wall which seals off said tank in the rest position,
characterized in that said bottom wall has at least one slot adapted to open under the effect of a predetermined minimum pressure, so that the product is dispensed with a predetermined precompression sufficient to obtain good spraying of the product, said predetermined pressure threshold being defined by the geometry of said bottom wall and / or the thickness of said bottom wall and / or the characteristics of the material of said bottom wall and / or the dimensions of said slot.

Avantageusement, ladite partie centrale dudit au moins un élément d'obturation comporte un alésage axial fermé d'un côté par ladite paroi de fond réalisée en un matériau élastiquement déformable, et ladite fente s'ouvre par déformation de ladite paroi de fond en réponse à une pression minimale prédéterminée exercée sur elle.Advantageously, said central part of said at least a sealing element has a closed axial bore on one side by said bottom wall made of a material elastically deformable, and said slot opens by deformation of said bottom wall in response to a predetermined minimum pressure exerted on it.

Avantageusement, ledit élément d'obturation est adapté à recevoir l'extrémité d'un organe d'actionnement d'un pulvérisateur de produit fluide, ledit organe d'actionnement comportant un canal d'expulsion de produit et ladite extrémité de l'organe d'actionnement étant réalisée de manière concave de telle sorte que sous l'effet d'une pression prédéterminée créée à l'intérieur du réservoir lors de l'actionnement dudit organe d'actionnement, ladite paroi de fond de l'élément d'obturation se déforme vers l'extérieur du réservoir, à l'intérieur de ladite extrémité concave, pour réaliser l'ouverture de la fente et la distribution avec précompression du produit contenu dans le réservoir à travers ladite canal d'expulsion.Advantageously, said closure element is adapted to receive the end of an actuator of a fluid sprayer, said member actuator comprising a product expulsion channel and said end of the actuator being concave so that under the effect of a predetermined pressure created inside of the reservoir upon actuation of said member actuation, said bottom wall of the element shutter is deformed towards the outside of the tank, the interior of said concave end, to achieve opening the slot and dispensing with precompression of the product contained in the through said expulsion channel.

Avantageusement, l'organe d'actionnement comporte un épaulement coopérant avec une zone d'appui dudit élément d'obturation pour transmettre la force d'actionnement et déplacer ledit élément d'obturation dans ledit réservoir pour distribuer avec précompression le produit contenu dans le réservoir.Advantageously, the actuating member comprises a shoulder cooperating with a support zone of said element shutter to transmit the actuating force and moving said closure member into said reservoir to pre-compress the product contained in the tank.

Selon une variante de réalisation, ledit au moins élément d'obturation est adapté à recevoir un arrangement de remplissage du réservoir pour remplir le réservoir avec le produit avant ou après son assemblage dans un dispositif de distribution de produit fluide.According to an alternative embodiment, said at least obturation element adapted to receive an arrangement filling tank to fill the tank with the product before or after its assembly in a fluid dispenser.

Avantageusement, ledit arrangement de remplissage comporte un tube de remplissage qui, en exerçant une certaine pression sur ladite paroi de fond, déforme celle-ci vers l'intérieur du réservoir pour traverser ladite fente ouverte.Advantageously, said filling arrangement has a filling tube which, by exerting a certain pressure on said bottom wall, deforms it towards the inside of the tank to cross said open slot.

Avantageusement, ledit arrangement de remplissage comporte une bride radiale coopérant avec l'élément d'obturation et la paroi du réservoir de telle sorte que la pression exercée par le tube pour traverser la fente ne déplace pas ledit élément d'obturation à l'intérieur du réservoir.Advantageously, said filling arrangement has a radial flange cooperating with the element shutter and the tank wall so that the pressure exerted by the tube to pass through the slit does not move said closure member within the tank.

Selon une variante de réalisation préférée, le dispositif de fermeture et/ou de remplissage comporte un premier élément d'obturation agissant en tant que bouchon de fermeture étanche en position de repos et en tant que piston lors de la distribution du produit, et un second élément d'obturation agissant en tant que bouchon de fermeture étanche et/ou en tant qu'élément de remplissage.According to a preferred embodiment, the closing and / or filling device comprises a first sealing element acting as a plug sealing in the rest position and as piston during product distribution, and a second sealing element acting as a stopper watertight closure and / or as a filling element.

Avantageusement, un organe rigide creux, est disposé dans ledit alésage dudit second élément d'obturation et est adapté à recevoir un arrangement de remplissage du réservoir, comportant un tube de remplissage qui, en exerçant une certaine pression sur ladite paroi de fond, déforme celle-ci vers l'intérieur du réservoir pour traverser ladite fente ouverte.Advantageously, a hollow rigid member is disposed in said bore of said second obturation element and is suitable for receiving a filling arrangement of the tank, comprising a filling tube which, in exerting a certain pressure on said bottom wall, deforms it towards the inside of the tank to cross said open slit.

Avantageusement, ledit organe rigide creux comporte une bride radiale coopérant avec le second élément d'obturation et la paroi du réservoir de telle sorte que la pression exercée par le tube pour traverser la fente ne déplace pas ledit second élément d'obturation à l'intérieur du réservoir.Advantageously, said hollow rigid member comprises a radial flange cooperating with the second element shutter and the tank wall so that the pressure exerted by the tube to pass through the slit does not move said second shutter member to inside the tank.

Selon une autre variante de réalisation, le réservoir comporte en outre un troisième élément d'obturation disposé fixement entre les premier et second éléments d'obturation, ledit troisième élément d'obturation séparant de manière étanche le réservoir en deux sous-réservoirs, chaque sous-réservoir comportant un produit différent, par exemple une poudre et un liquide, et ledit second élément d'obturation agissant en outre en tant que piston pour mélanger les deux produits dans un des sous-réservoirs.According to another alternative embodiment, the tank further includes a third closure element fixedly arranged between the first and second elements shutter, said third shutter element sealing the tank into two sub-tanks, each sub-tank containing a product different, for example a powder and a liquid, and said second shutter member further acting as piston to mix the two products in one of the sub-tanks.

Avantageusement, le troisième élément d'obturation comporte un organe rigide creux inséré dans son alésage central, qui permet l'ouverture de la fente de la paroi de fond sous l'effet d'une pression minimale créée dans un des sous-réservoirs, et qui empêche cette ouverture sous l'effet d'une pression créée dans l'autre sous-réservoir.Advantageously, the third obturation element has a hollow rigid member inserted in its bore central, which allows the opening of the slot in the wall of melts under the effect of a minimum pressure created in a sub-tanks, and which prevents this opening under the effect of a pressure created in the other sub-tank.

De préférence, lorsque le tube de remplissage de l'arrangement de remplissage traverse ladite fente, il ouvre celle-ci de telle sorte qu'une ouverture est formée autour dudit tube, permettant à l'air de s'échapper au fur et à mesure du remplissage du réservoir avec le produit.Preferably, when the filling tube of the filling arrangement passes through said slot, it open it so that an opening is formed around said tube, allowing air to escape as and as the reservoir is filled with the product.

La présente invention a également pour objet un pulvérisateur de produit fluide comportant un organe d'actionnement et un réservoir.The present invention also relates to a fluid sprayer comprising a member actuator and a tank.

De préférence, le réservoir est réalisé en verre et le ou les élément(s) d'obturation en un matériau inerte vis-à-vis du produit contenu dans le réservoir, et ledit produit est finement pulvérisé avec précompression à chaque actionnement du dispositif.Preferably, the tank is made of glass and the or the closure element (s) made of a material that is inert with respect to of the product contained in the tank, and said product is finely sprayed with precompression each actuation of the device.

Ces caractéristiques et avantages et d'autres de la présente invention apparaítront plus clairement au cours de la description détaillée suivante de plusieurs modes de réalisation de la présente invention, donnés à titre d'exemples non limitatifs, en regard des dessins joints, sur lesquels :

  • la figure 1 représente une vue schématique en coupe d'un réservoir comportant un dispositif de fermeture et de remplissage réalisé selon un premier mode de réalisation de l'invention, en position de fermeture,
  • la figure 2 est une vue similaire à la figure 1 en position de distribution,
  • la figure 3a est une vue schématique en coupe du dispositif des figures 1 et 2, en position de remplissage,
  • la figure 3b est une vue schématique en coupe transversale selon la ligne A-A de la figure 3a,
  • la figure 4 est une vue schématique en coupe d'un réservoir comportant un dispositif de fermeture et de remplissage réalisé selon un second mode de réalisation de la présente invention, en position de fermeture,
  • la figure 5a est une vue schématique en coupe du dispositif de la figure 4, en position de remplissage,
  • la figure 5b est un vue schématique en coupe transversale selon la ligne A-A de la figure 5a, et
  • la figure 6 est une vue schématique en coupe d'un réservoir comportant un dispositif de fermeture et de remplissage réalisé selon une autre variante de réalisation de la présente invention, en position de fermeture.
These characteristics and advantages and others of the present invention will appear more clearly during the following detailed description of several embodiments of the present invention, given by way of nonlimiting examples, with reference to the accompanying drawings, in which:
  • FIG. 1 represents a schematic sectional view of a reservoir comprising a closure and filling device produced according to a first embodiment of the invention, in the closed position,
  • FIG. 2 is a view similar to FIG. 1 in the dispensing position,
  • FIG. 3a is a schematic sectional view of the device of FIGS. 1 and 2, in the filling position,
  • FIG. 3b is a schematic view in cross section along the line AA in FIG. 3a,
  • FIG. 4 is a schematic sectional view of a reservoir comprising a closure and filling device produced according to a second embodiment of the present invention, in the closed position,
  • FIG. 5a is a schematic sectional view of the device of FIG. 4, in the filling position,
  • FIG. 5b is a diagrammatic view in cross section along the line AA in FIG. 5a, and
  • Figure 6 is a schematic sectional view of a reservoir comprising a closure and filling device produced according to another alternative embodiment of the present invention, in the closed position.

Bien que particulièrement destinée aux pulvérisateurs de médicaments liquides, la présente invention est applicable à tous les pulvérisateurs de produit fluide. Seuls les éléments ayant un rapport avec la présente invention sont représentés sur les dessins et décrits dans la description détaillée ci-après, et les autres parties constitutives des dispositifs de distribution de produit fluide, qui peuvent être quelconques et de type connu, ne sont donc ni représentés, ni décrits ci-après. Although particularly intended for sprayers of liquid drugs, the present invention is applicable to all fluid sprayers. Only items related to this invention are shown in the drawings and described in the detailed description below, and the other parts of product distribution devices fluid, which can be any and of known type, does not are therefore neither shown nor described below.

En référence aux figures 1 à 3, il est représenté une première variante de réalisation du dispositif de fermeture et/ou de remplissage pour réservoir selon la présente invention. Le réservoir 10, dont les parois 11 sont de préférence réalisées en verre, ne comporte dans cette variante qu'une seule ouverture, obturée par un dispositif de fermeture et de remplissage selon l'invention. Ce dispositif de fermeture et/ou de remplissage comporte un élément d'obturation 20 qui agit en tant que bouchon de fermeture étanche en position de repos, représenté sur la figure 1. Cet élément d'obturation 20 comporte une partie annulaire 21 dont le diamètre extérieur correspondant sensiblement au diamètre intérieur du réservoir 10, et une partie centrale 22 permettant de réaliser l'obturation étanche du réservoir en position de repos. La partie centrale 22 comporte une paroi de fond 23 qui est pourvue d'une ou plusieurs fentes 24 adaptées à s'ouvrir sous l'effet d'une pression minimale prédéterminée. Avantageusement, comme représenté sur la figure 1, l'élément d'obturation 20 comporte un alésage axial 22 qui est fermé d'un côté par ladite paroi de fond 23, et ladite paroi de fond est de préférence réalisée en un matériau élastiquement déformable. Avantageusement, l'élément d'obturation 20, dans son ensemble, est réalisé dans le même matériau, ce qui en facilite la fabrication. Dans la variante de réalisation représentée sur les figures 1, 2 et 3, l'élément d'obturation 20 agit en tant que bouchon de fermeture étanche en position de repos (figure 1), en tant que piston lors de la distribution du produit (figure 2), et éventuellement en tant qu'élément de remplissage lorsque le réservoir 10 est rempli avec le produit liquide (figures 3a et 3b).Referring to Figures 1 to 3, it is shown a first alternative embodiment of the device closure and / or filling for tank according to the present invention. Reservoir 10, whose walls 11 are preferably made of glass, do not comprises in this variant only one opening, closed by a closing device and filling according to the invention. This device closure and / or filling has an element shutter 20 which acts as a stopper sealed in the rest position, shown in FIG. 1. This closure element 20 comprises an annular part 21 whose diameter outside corresponding substantially to the inside diameter of the reservoir 10, and a central part 22 making it possible to seal the tank in position of rest. The central part 22 has a bottom wall 23 which is provided with one or more slots 24 adapted to open under minimal pressure predetermined. Advantageously, as shown in the Figure 1, the closure element 20 has a bore axial 22 which is closed on one side by said bottom wall 23, and said bottom wall is preferably made of an elastically deformable material. advantageously, the shutter element 20, as a whole, is produced in the same material, which makes it easier to manufacture. In the variant shown on the Figures 1, 2 and 3, the closure element 20 acts as that sealing plug in the rest position (figure 1), as a piston during the distribution of the product (figure 2), and possibly as an element when the tank 10 is filled with the liquid product (Figures 3a and 3b).

L'étanchéité est réalisée en position de repos par la paroi de fond 23 de l'élément d'obturation 20 dont la fente 24 est maintenue fermée de manière étanche par la pression exercée par les parois 11 du réservoir 10 sur la partie annulaire 21 et la paroi de fond 23 de l'élément d'obturation 20. L'élément d'obturation comporte en outre avantageusement une bride radiale 29 qui se prolonge à l'extérieur sur le bord supérieur du réservoir 10, pour former une butée contre tout déplacement accidentel de l'élément d'obturation 20 à l'intérieur du réservoir 10.The sealing is carried out in the rest position by the bottom wall 23 of the closure element 20, the slot 24 is kept sealed by the pressure exerted by the walls 11 of the reservoir 10 on the annular part 21 and the bottom wall 23 of the element shutter 20. The shutter element further comprises advantageously a radial flange 29 which extends to the outside on the upper edge of the tank 10, to form a stop against any accidental movement of the closure element 20 inside the tank 10.

Pour la distribution du produit, l'alésage central 22 de l'élément d'obturation 20 est adapté à recevoir l'extrémité 32 d'un organe d'actionnement 30 du dispositif de distribution de produit fluide (non représenté) par l'intermédiaire duquel la force d'actionnement exercée par l'utilisateur sur ledit organe d'actionnement 30 est transmise à l'élément d'obturation 20.For the distribution of the product, the central bore 22 the closure element 20 is adapted to receive the end 32 of an actuating member 30 of the device dispensing fluid (not shown) by through which the actuating force exerted by the user on said actuator 30 is transmitted to the closure element 20.

Ladite extrémité 32 de l'organe d'actionnement 30 coopère avec l'alésage central 22, avantageusement avec une zone d'appui 28 dudit élément d'obturation 20, par l'intermédiaire d'un épaulement 38 de l'organe d'actionnement 30, pour transmettre ladite force d'actionnement. De préférence, comme représenté sur la figure 2, l'extrémité 32 de l'organe d'actionnement 30 présente une forme concave de telle sorte que la paroi de fond 23 peut se déformer à l'intérieur de ladite extrémité concave 32 pour permettre l'ouverture de la fente 24. Ainsi, en référence à la figure 2, qui représente le dispositif en cours de distribution, lorsque l'utilisateur exerce une pression sur l'organe d'actionnement 30, cette pression est transmise à l'élément d'obturation 20. La pression augmente donc à l'intérieur du réservoir 10 jusqu'à ce que le seuil minimal prédéterminé soit atteint qui entraíne la déformation de la paroi de fond 23 vers la partie concave de l'extrémité 32 de l'organe d'actionnement 30, et donc l'ouverture de la fente 24. Simultanément, la bride radiale 29 de l'élément d'obturation 20 se rabat le long de la tige d'actionnement 30 sous l'effet de la force libérée par l'ouverture de la fente 24 de sorte que l'élément d'obturation 20 se transforme en piston coulissant à l'intérieur des parois 11 du réservoir 10, qui forme alors le corps de pompe. La précompression réalisée par l'élément d'obturation 20 garantit que le produit contenu dans le réservoir est expulsé hors du réservoir avec une pression optimale.Said end 32 of the actuating member 30 cooperates with the central bore 22, advantageously with a support zone 28 of said closure element 20, by through a shoulder 38 of the organ actuator 30, to transmit said force actuating. Preferably, as shown in the Figure 2, the end 32 of the actuator 30 has a concave shape so that the wall of bottom 23 can deform inside said end concave 32 to allow the opening of the slot 24. Thus, with reference to FIG. 2, which represents the device being distributed, when the user exerts pressure on the actuating member 30, this pressure is transmitted to the shutter element 20. The pressure therefore increases inside the tank 10 until the predetermined minimum threshold is reached which causes the deformation of the bottom wall 23 towards the concave part of the end 32 of the organ actuation 30, and therefore the opening of the slot 24. Simultaneously, the radial flange 29 of the element shutter 20 folds down along the actuating rod 30 under the effect of the force released by the opening of the slot 24 so that the closure element 20 transforms into a sliding piston inside the walls 11 of the reservoir 10, which then forms the pump body. The precompression achieved by the closure element 20 guarantees that the product contained in the tank is expelled from the tank with optimal pressure.

L'élément d'obturation 20 agit alors en tant que piston et est déplacé vers le fond du réservoir 10, pour expulser le produit que celui-ci contient, à travers la fente 24 et un canal d'expulsion prévu dans la tige d'actionnement 30. Le seuil de précompression nécessaire pour déformer la paroi de fond 23 et ouvrir la fente 24 peut être déterminé en choisissant une épaisseur et/ou une géométrie appropriée de ladite partie de fond 23. En particulier, comme représenté sur la figure 1, la géométrie de la paroi de fond 23 est telle qu'elle forme une surface courbe, notamment concave, sur le côté dirigé vers la tige d'actionnement 30. Cette forme concave forme une résistance à la déformation qui permet de définir précisément le seuil de pression nécessaire pour l'ouverture de la fente 24. Lorsque ce seuil est atteint, la fente s'ouvre de manière instantanée, en inversant brutalement sa courbure, comme visible sur la figure 2. De même, ladite paroi de fond 23 peut comporter une fente longitudinale 24, comme représentée sur la figure 3b, ou deux ou plusieurs fentes réalisées par exemple en forme de croix, ou tout autre motif approprié.The shutter member 20 then acts as piston and is moved to the bottom of the tank 10, to expel the product it contains, through the slot 24 and an expulsion channel provided in the rod actuation 30. The precompression threshold required to deform the bottom wall 23 and open the slot 24 can be determined by choosing a thickness and / or a appropriate geometry of said bottom portion 23. In particular, as shown in Figure 1, the geometry of the bottom wall 23 is such that it forms a curved surface, notably concave, on the directed side towards the actuating rod 30. This concave shape forms a resistance to deformation which makes it possible to define precisely the pressure threshold needed to the opening of the slot 24. When this threshold is reached, the slot opens instantly, reversing suddenly its curvature, as seen in Figure 2. From even, said bottom wall 23 may have a slot longitudinal 24, as shown in FIG. 3b, or two or more slots made for example in the form of cross, or any other appropriate motif.

Sur les figures 3a et 3b, l'élément d'obturation 20 du dispositif des figures 1 et 2 est représenté en position de remplissage. Dans ce mode de réalisation, le remplissage est réalisé à travers le même élément d'obturation 20 qui sert de bouchon de fermeture en position de repos, et de piston en cours de distribution. Dans ce cas, le remplissage doit généralement être réalisé avant l'assemblage final du dispositif de distribution de produit fluide, dans lequel ledit réservoir sera adapté. Toutefois, le réservoir est automatiquement fermé dès la fin du remplissage par fermeture de la fente 24 après retrait du tube de remplissage.In FIGS. 3a and 3b, the shutter element 20 of the device of Figures 1 and 2 is shown in position filling. In this embodiment, the filling is carried out through the same element shutter 20 which serves as a closure plug in rest position, and piston being dispensed. In this case, the filling must generally be carried out before the final assembly of the distribution device fluid product, in which said reservoir will be adapted. However, the tank is automatically closed as soon as end of filling by closing the slot 24 after removal of the filling tube.

Pour réaliser le remplissage, un arrangement de remplissage 40 vient s'adapter à l'intérieure de l'alésage central 22 de l'élément d'obturation 20, ledit arrangement de remplissage 40 comportant une partie de bride radiale 45 coopérant avec la bride 29 de l'élément d'obturation 20 et la paroi 11 du réservoir 10, comme représenté sur la figure 3b. L'arrangement de remplissage comporte en outre un tube de remplissage 41 qui vient s'appuyer par l'extérieur sur ladite paroi de fond 23 pour la déformer, ouvrir ladite fente 24 et pénétrer à l'intérieur du réservoir 10. Comme représenté schématiquement sur la figure 3b, on voit que la pénétration du tube de remplissage 41 à travers la fente 24 ménage des ouvertures latérales 27 autour dudit tube de remplissage 41, qui permettent à l'air contenu dans le réservoir de s'échapper pendant le remplissage dudit réservoir. La bride radiale 45, qui coopère à la fois avec l'élément d'obturation 20 et la paroi 11 du réservoir, évite lors de l'application de la force sur la paroi de fond 23 pour déformer celle-ci afin de permettre la pénétration du tube de remplissage 41, que ledit élément d'obturation 20 ne soit déplacé à l'intérieur du réservoir.To carry out the filling, an arrangement of filling 40 fits inside the bore central 22 of the closure element 20, said arrangement filling 40 comprising a radial flange part 45 cooperating with the flange 29 of the closure element 20 and the wall 11 of the reservoir 10, as shown in the Figure 3b. The filling arrangement further comprises a filling tube 41 which is supported by the outside on said bottom wall 23 to deform it, open said slot 24 and enter the interior of the tank 10. As shown schematically on the Figure 3b, we see that the penetration of the tube filling 41 through the slot 24 cleaning the openings side 27 around said filling tube 41, which allow air in the tank to escape during filling of said tank. The radial flange 45, which cooperates with both the closure element 20 and the wall 11 of the tank, avoids during application force on the bottom wall 23 to deform it to allow penetration of the filling tube 41, that said closure element 20 is not moved inside the tank.

Cette première variante de la présente invention qui ne comporte qu'un seul élément d'obturation 20 agissant à la fois en tant que bouchon de fermeture, piston, et élément de remplissage permet de résoudre tous les problèmes susmentionnés, sauf qu'il n'autorise généralement pas un remplissage du réservoir après assemblage final du dispositif de distribution de produit fluide.This first variant of the present invention which has only one shutter element 20 acting at both as a closure cap, piston, and filling element solves all above problems except that it does not allow usually not filling the tank after final assembly of the product distribution device fluid.

Pour répondre à cette exigence, la présente invention prévoit avantageusement un second élément d'obturation 120 disposé de l'autre côté du réservoir 10 et qui agit en tant que bouchon de fermeture et en tant qu'élément de remplissage pour permettre un remplissage du réservoir, même après son assemblage dans le dispositif de distribution ou de pulvérisation. L'élément d'obturation 120 est réalisé de manière similaire à l'élément d'obturation 20, de préférence il est réalisé de manière identique, c'est-à-dire qu'il comprend une partie annulaire 121 et une partie centrale 122, comportant de préférence un alésage central 122, obturé d'un côté par une paroi de fond déformable 123 qui incorpore une fente 124 qui peut s'ouvrir sous l'effet d'une force prédéterminée. De préférence, un organe rigide creux 130 est disposé dans ledit alésage 122 de l'élément de remplissage 120. La paroi d'extrémité radiale 132 dudit organe rigide creux 130 est de préférence réalisée de manière plate, c'est-à-dire qu'elle est disposée face à ladite paroi de fond déformable 123 en empêchant celle-ci de se déformer vers l'extérieur du réservoir 10 sous l'effet d'une pression créée à l'intérieur dudit réservoir. Ainsi, on assure une parfaite étanchéité pendant la distribution du produit à travers l'autre extrémité du réservoir.To meet this requirement, the present invention advantageously provides a second closure element 120 arranged on the other side of the tank 10 and which acts in as a closure cap and as part of filling to allow filling of the tank, even after it has been assembled in the dispensing or spraying. The shutter element 120 is made similar to the element shutter 20, preferably it is made so identical, i.e. it includes a part annular 121 and a central portion 122, comprising preferably a central bore 122, closed on one side by a deformable bottom wall 123 which incorporates a slot 124 which can open due to force predetermined. Preferably, a hollow rigid member 130 is disposed in said bore 122 of the element of filling 120. The radial end wall 132 of said hollow rigid member 130 is preferably made of flat way, that is to say it is arranged facing said deformable bottom wall 123 by preventing the latter to deform towards the outside of the reservoir 10 under the effect of pressure created inside said tank. Thus, we ensure a perfect seal during the distribution of the product through the other tank end.

Ledit élément d'obturation 120 agit donc en tant que bouchon de fermeture étanche en position de repos et pendant la distribution du produit.Said closure element 120 therefore acts as sealed closure cap in rest position and during product distribution.

Il agit aussi en tant qu'élément de remplissage pour permettre un remplissage du réservoir. A cet effet, l'organe rigide creux 130 comporte une bride radiale 135 qui coopère avec la bride radiale 129 de l'élément de remplissage 120 et avec la paroi 11 du réservoir 10 de telle manière à empêcher un déplacement dudit élément 120 à l'intérieur du réservoir 10 lorsque une pression est exercée depuis l'extérieur sur la paroi de fond 123, notamment lors du remplissage.It also acts as a filler for allow filling of the tank. To this end, the hollow rigid member 130 has a radial flange 135 which cooperates with the radial flange 129 of the element of filling 120 and with the wall 11 of the reservoir 10 of so as to prevent displacement of said element 120 inside the tank 10 when pressure is exerted from the outside on the bottom wall 123, especially during filling.

Le remplissage du réservoir 10 dans cette seconde variante de réalisation représentée sur les figures 5a et 5b, est réalisé de manière similaire au remplissage du réservoir de la première variante représentée sur la figure 3a, à la différence que ce remplissage peut être réalisé alors que le réservoir est déjà assemblé dans le dispositif de distribution de produit fluide. En effet, l'assemblage de remplissage 140, en particulier le tube de remplissage 141 est amené à travers ledit organe rigide creux 130 pour s'appuyer sur la paroi de fond 123, la déformer et traverser la fente 124. L'élément de remplissage 120 n'étant pas destiné à servir en tant que piston pendant la distribution du produit, il peut être aisément accessible par le dispositif de remplissage même lorsque le réservoir est déjà assemblé dans l'appareil. Dans l'exemple représenté sur les figures 5a et 5b, le réservoir 10 est retourné par rapport à la position représentée sur la figure 4 pour permettre à l'air de s'échapper à travers les ouvertures 127 prévues autour du tube de remplissage 141 dans la fente 124, et éviter toute fuite de liquide à travers lesdites ouvertures 127.The filling of the reservoir 10 in this second variant embodiment shown in FIGS. 5a and 5b, is carried out similarly to filling the tank of the first variant shown on the Figure 3a, with the difference that this filling can be when the tank is already assembled in the fluid dispenser. Indeed, the filling assembly 140, in particular the tube filling 141 is brought through said rigid member hollow 130 to rest on the bottom wall 123, the deform and pass through slot 124. The element of filling 120 not intended to serve as piston during product dispensing, it can be easily accessible by the filling device itself when the tank is already assembled in the device. In the example shown in Figures 5a and 5b, the tank 10 is returned relative to the position shown in Figure 4 to allow air to escape through the openings 127 provided around the filling tube 141 in slot 124, and avoid any leakage of liquid through said openings 127.

L'élément de remplissage 120 a été représenté sur les figures 4 et 5 en conjonction avec un élément de remplissage 20 décrit précédemment dans le cadre de la première variante de réalisation.The filling element 120 has been shown on the Figures 4 and 5 in conjunction with an element of filling 20 described previously in the context of the first variant.

En référence à la figure 6, il est représenté une troisième variante de réalisation, adaptée plus particulièrement à un dispositif monodose pour médicament lyophilisé. Dans cette variante, le réservoir 10 est séparé en deux sous-réservoirs 110 et 210 par un troisième élément d'obturation 220 qui est disposé fixement, via une partie de bride radiale 229, à l'intérieur dudit réservoir 10. Ce troisième élément d'obturation 220 est réalisé de manière similaire au premier et second éléments d'obturation 20 et 120, et comporte notamment une partie annulaire 221 insérée de manière étanche à l'intérieur du réservoir 10 et un alésage central 222 comportant une paroi de fond 223 pourvue d'une fente 224 adaptée à s'ouvrir sous l'effet d'une pression prédéterminée. Dans cet exemple de réalisation, le sous-réservoir 110 comprend une poudre lyophilisée, et le sous-réservoir 210 comprend un solvant liquide pour le médicament lyophilisé. Le second élément d'obturation 120, disposé sur la figure 6 sur le côté inférieur du réservoir 10, agit dans cette variante de réalisation en tant que bouchon de fermeture en position de repos, éventuellement en tant qu'élément de remplissage pour remplir le sous-réservoir 210, mais également en tant que piston pour réaliser le mélange du produit lyophilisé et de son solvant. L'actionnement de ce dispositif est réalisé en deux phases. Dans la première phase, le liquide contenu dans le sous-réservoir 210 est transféré dans le sous-réservoir 110 à travers la fente 224 prévue dans la paroi de fond 223 du troisième élément d'obturation 220 en exerçant une pression dans le sous-réservoir 210 par l'intermédiaire d'un élément d'actionnement (non représenté) agissant sur l'organe rigide creux 130 du second élément d'obturation 120. Ladite pression crée dans le sous-réservoir 210 entraíne la déformation de la paroi de fond 223 et l'ouverture de la fente 224 de sorte que le solvant liquide est transféré à l'intérieur du sous-réservoir 110 par l'intermédiaire du piston 120. Lorsque le produit et le solvant se sont mélangés dans le sous-réservoir 110, ledit mélange est expulsé à travers le canal d'expulsion 31 de l'organe d'actionnement 30 au moyen du premier élément d'obturation 20 comme décrit précédemment en référence aux figures 1, 2 et 3. Avantageusement pour garantir l'étanchéité pendant l'expulsion du mélange, le troisième élément d'obturation 220 comporte un organe rigide creux 230 inséré dans son alésage central 222 et dont l'extrémité 232 est réalisée de manière plate. De cette manière, la paroi de fond 223 peut se déformer en direction du sous-réservoir 110 pour permettre le passage du solvant lors de la première phase, mais ne peut pas se déformer dans l'autre sens, lors d'une surpression créée dans le sous-réservoir 110 lors de l'expulsion du mélange, garantissant ainsi l'étanchéité. L'organe rigide 130 inséré dans l'alésage central 122 du second élément d'obturation 120 présente avantageusement également une extrémité 132 réalisée de cette manière pour éviter toute fuite de solvant pendant la première phase, pendant laquelle une surpression est créée à l'intérieur du sous-réservoir 210. Dans ce cas, la fente 124 ne peut s'ouvrir que vers l'intérieur pour laisser passer un tube de remplissage, si besoin est.Referring to Figure 6, there is shown a third variant, adapted more particularly a single dose drug device lyophilized. In this variant, the reservoir 10 is separated into two sub-tanks 110 and 210 by a third obturation element 220 which is fixedly disposed, via a radial flange portion 229, inside said tank 10. This third closure element 220 is made of similar to the first and second elements shutter 20 and 120, and in particular comprises a part ring 221 inserted tightly inside the reservoir 10 and a central bore 222 comprising a bottom wall 223 provided with a slot 224 adapted to open under the effect of a predetermined pressure. In this embodiment, the sub-tank 110 comprises a lyophilized powder, and the sub-reservoir 210 comprises a liquid solvent for the lyophilized drug. The second closure element 120, arranged in FIG. 6 on the lower side of the tank 10, acts in this variant as a closure cap in the rest position, possibly as part of filling to fill the sub-tank 210 but also as a piston for mixing the lyophilized product and its solvent. The actuation of this device is made in two phases. In the first phase, the liquid contained in the sub-tank 210 is transferred to sub-tank 110 through the slot 224 provided in the bottom wall 223 of the third element shutter 220 by applying pressure in the sub-tank 210 through an element actuator (not shown) acting on the organ rigid hollow 130 of the second closure element 120. Said pressure created in the sub-tank 210 causes the deformation of the bottom wall 223 and the opening of slot 224 so that the liquid solvent is transferred inside the sub-tank 110 via the piston 120. When the product and the solvent have mixed in the sub-tank 110, said mixture is expelled through the expulsion channel 31 of the organ actuator 30 by means of the first closure element 20 as described previously with reference to FIGS. 1, 2 and 3. Advantageously to guarantee sealing during the expulsion of the mixture, the third filling element 220 has a hollow rigid member 230 inserted in its central bore 222 and the end 232 of which is formed flatly. In this way, the bottom wall 223 can deform in the direction of the sub-tank 110 to allow the passage of the solvent during the first phase, but cannot deform in the other direction, during a overpressure created in the sub-tank 110 during the expulsion of the mixture, thus guaranteeing sealing. The rigid member 130 inserted in the central bore 122 of the second closure element 120 advantageously has also an end 132 made in this way to avoid any solvent leakage during the first phase, during which an overpressure is created inside of the sub-tank 210. In this case, the slot 124 cannot open only inward to let a tube pass filling, if necessary.

La présente invention permet donc de réaliser de manière très simple et peu coûteuse un dispositif de fermeture et de remplissage pour réservoir qui permet de surmonter tous les inconvénients mentionnés précédemment. Le réservoir peut comporter un seul élément d'obturation mais dans le mode de réalisation préféré, il comporte deux éléments d'obturation, un à chaque extrémité du réservoir, le premier servant de bouchon étanche en position de repos et de piston lors de la distribution du produit, et le second agissant en tant que bouchon de fermeture étanche et en tant qu'élément de remplissage, permettant notamment de remplir le réservoir après son assemblage dans un dispositif ou pulvérisateur quelconque approprié.The present invention therefore makes it possible to carry out very simple and inexpensive way a device closure and filling for tank which allows overcome all the disadvantages mentioned above. The tank may have a single closure element but in the preferred embodiment, it has two sealing elements, one at each end of the tank, the first serving as a sealed stopper in the rest position and piston when dispensing the product, and the second acting as a watertight closure cap and as a filler, allowing in particular fill the tank after assembly in a any suitable device or sprayer.

La présente invention a été décrite en référence à trois variantes de réalisation, mais il est entendu que celles-ci ne sont pas limitatives, l'homme de l'art pouvant réaliser diverses modifications sans sortir du cadre de la présente invention telle que définie dans les revendications annexées. Par exemple, l'invention n'est pas limitée aux dispositifs monodoses. Par exemple, des moyens d'arrêt ou similaire peuvent être prévus pour réaliser l'expulsion du produit contenu dans le réservoir en deux ou plusieurs actionnements du dispositif.The present invention has been described with reference to three variant embodiments, but it is understood that these are not limiting, those skilled in the art can make various modifications without leaving the scope of the present invention as defined in appended claims. For example, the invention is not not limited to single dose devices. For example, stop means or the like may be provided for expel the product contained in the tank in two or more actuations of the device.

Claims (15)

  1. A reservoir (10) for a fluid spray, said reservoir containing a fluid to be dispensed, and provided with a closure and/or filling device for closing and/or filling said reservoir, said device comprising at least one closure element (20, 120, 220) acting as a leaktight closure stopper when at rest, and as a piston during the dispensing of the product, said at least one closure element (20, 120, 220) comprising:
    an annular portion (21, 121, 221) whose outside diameter corresponds substantially to the inside diameter of the reservoir (10), said annular portion (21, 121, 221) being inserted in leaktight manner in said reservoir; and
    a central portion (22, 122, 222) having an end wall (23, 123, 223) which closes off said reservoir (10) in leaktight manner when in the rest position;
    said reservoir being characterized in that said end wall (23, 123, 223) is provided with at least one slit (24, 124, 224) suitable for opening under the effect of at least a predetermined minimum pressure, so that a part or the whole of the fluid contained in the reservoir (10) is first put under pressure, and then dispensed with a predetermined precompression that is sufficient to provide a good spray of fluid, said predetermined pressure threshold being defined by the geometrical shape of said end wall (23, 123, 223) and/or by the thickness of said end wall (23, 123, 223) and/or by the characteristics of the material of said end wall (23, 123, 223) and/or by the dimensions of said slit (24, 124, 224) .
  2. A reservoir according to claim 1, in which said central portion of said at least one closure element (20, 120, 220) is provided with an axial bore (22, 122, 222) that is closed at one end by said end wall (23, 123, 223) which is made of an elastically-deformable material, and said slit (24, 124, 224) opens by means of said end wall (23, 123, 223) being deformed in response to at least a predetermined minimum pressure being exerted on it.
  3. A reservoir according to claim 1 or 2, in which said closure element (20) is suitable for receiving the end (32) of an actuating member (30) for actuating a fluid spray for spraying a fluid, said actuating member (30) being provided with a fluid expulsion channel (31) and said end (32) of the actuating member being made to be concave so that, under the effect of a predetermined pressure generated inside the reservoir (10) when said actuating member (30) is actuated, said end wall (23) of the closure element (20) deforms towards the outside of the reservoir (10), into said concave end (32), thereby opening the slit (24), and dispensing the fluid contained in the reservoir (10) through said expulsion channel (31) and with precompression.
  4. A reservoir according to claim 3, in which the actuating member (30) is provided with a shoulder (38) that co-operates with an abutment zone (28) of said closure element (20) so as to transmit the actuating force and so as to move said closure element (20) in said reservoir (10) for the purpose of dispensing the fluid in the reservoir, with precompression.
  5. A reservoir according to any preceding claim, in which at least said closure element (20, 120) is suitable for receiving a filling fitting (40, 140) for filling the reservoir with the fluid before or after it is assembled in a fluid spray for spraying a fluid.
  6. A reservoir according to claim 5, in which said filling fitting (40) is provided with a filling tube (41) which, by exerting a certain amount of pressure on said end wall (23), deforms it towards the inside of the reservoir so as to pass through said slit (24) as open.
  7. A reservoir according to claim 6, in which said filling fitting (40) is provided with a radial flange (45) co-operating with the closure element (20) and with the wall (11) of the reservoir (10) so that the pressure exerted by the tube (41) to enable it to pass through the slit (24) does not displace said closure element (20) inside the reservoir (10).
  8. A reservoir according to any preceding claim, in which the closure and/or filling device comprises a first closure element (20) acting as a leaktight closure stopper when in the rest position and as a piston while the fluid is being dispensed, and a second closure element (120) acting as a leaktight closure stopper and/or as a filling element.
  9. A reservoir according to claims 2, 5, and 8, in which a hollow rigid member (130) is disposed in said bore (122) in said second closure element (120) and is suitable for receiving a filling fitting (140) for filling the reservoir, which fitting is provided with a filling tube (141) which, by exerting a certain amount of pressure on said end wall (123), deforms said end wall towards the inside of the reservoir so as to pass through said slit (124) as open.
  10. A reservoir according to claim 9, in which said hollow rigid member (130) is provided with a radial flange (135) co-operating with the second closure element (120) and with the wall (11) of the reservoir (10) so that the pressure exerted by the tube (141) to pass through the slit (124) does not displace said second closure element (120) inside the reservoir (10).
  11. A reservoir according to any one of claims 8 to 10, in which the reservoir (10) is further provided with a third closure element (220) disposed in fixed manner between the first and second closure elements (20, 120), said third closure element (220) separating the reservoir (10) in leaktight manner into two sub-reservoirs (110, 210), each sub-reservoir (110, 210) containing a different fluid, e.g. a powder and a liquid, and said second closure element (120) further acting as a piston to mix the two fluids in one of the sub-reservoirs (110).
  12. A reservoir according to claim 11, in which the third closure element (220) is provided with a hollow rigid member (230) which is inserted in its central bore (222), which makes it possible to open the slit (224) in the end wall (223) under the effect of at least a minimum pressure generated in one of the sub-reservoirs (210), and which prevents such opening under the effect of a pressure generated in the other sub-reservoir (110).
  13. A reservoir according to claims 5, 6, 7, 9, or 10, in which, when the filling tube (41, 141) of the filling fitting (40, 140) passes through said slit (24, 124), it opens said slit so that an opening (27, 127) is formed around said tube (41, 141), thereby enabling air to escape as the reservoir (10) fills with the fluid.
  14. A fluid spray for spraying a fluid, said fluid spray comprising an actuating member (30) and a reservoir (10) according to any one of claims 1 to 13.
  15. A spray according to claim 14, in which the reservoir (10) is made of glass, and the closure element(s) (20, 120, 220) is/are made of a substance that is inert relative to the fluid contained in the reservoir, and said fluid is sprayed finely and with precompression each time the spray is actuated.
EP19990950824 1998-10-26 1999-10-26 Reservoir provided with a device for closing and/or filling and sprayer for dispensing a fluid product comprising same Expired - Lifetime EP1124646B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9813837A FR2784969B1 (en) 1998-10-26 1998-10-26 TANK PROVIDED WITH A CLOSING AND FILLING DEVICE AND FLUID PRODUCT DISPENSING DEVICE COMPRISING SUCH A TANK
FR9813837 1998-10-26
PCT/FR1999/002590 WO2000024523A1 (en) 1998-10-26 1999-10-26 Reservoir provided with a device for closing and/or filling and device for dispensing a fluid product comprising same

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EP1124646A1 EP1124646A1 (en) 2001-08-22
EP1124646B1 true EP1124646B1 (en) 2004-04-21

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US (1) US6450216B1 (en)
EP (1) EP1124646B1 (en)
JP (1) JP2002537873A (en)
CN (1) CN1106887C (en)
DE (1) DE69916644D1 (en)
FR (1) FR2784969B1 (en)
WO (1) WO2000024523A1 (en)

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FR2832080B1 (en) * 2001-11-15 2004-09-24 Valois Sa FLUID PRODUCT DISPENSING DEVICE
FR2847834B1 (en) 2002-12-02 2006-06-02 Valois Sas DEVICE FOR DISPENSING FLUID PRODUCT
GB0302536D0 (en) * 2003-02-04 2003-03-12 Bespak Plc Container
US20050090766A1 (en) * 2003-10-24 2005-04-28 Renzo Montanari Tube for blood collecting with a vacuum method
ES2532290T3 (en) * 2008-10-23 2015-03-25 The Procter & Gamble Company Valve and dispenser comprising the same
US20110259923A1 (en) * 2010-04-26 2011-10-27 John Geoffrey Chan Plug And Valve System
CN103459990B (en) 2011-03-28 2016-03-16 菲什曼公司 For fluid distributor being connected to releasedly the system and method for distribution system
FR3101619B1 (en) * 2019-10-07 2021-12-17 Aptar France Sas Method of filling a fluid dispenser device
KR102604299B1 (en) * 2020-12-02 2023-11-28 주식회사 하나바이오 Medicant dispenser
US11617716B2 (en) 2021-06-10 2023-04-04 Belhaven BioPharma Inc. Dry powder formulations of epinephrine and associated methods
US12005185B2 (en) 2021-12-17 2024-06-11 Belhaven BioPharma Inc. Medical counter measures including dry powder formulations and associated methods

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US2475060A (en) * 1947-07-10 1949-07-05 Arthur E Smith Ampoule syringe
US3368558A (en) * 1964-08-21 1968-02-13 Sarnoff Two compartment cartridge
US3841329A (en) * 1972-09-11 1974-10-15 Upjohn Co Compact syringe
EP0150681B1 (en) * 1984-01-25 1987-12-23 Medicorp Holding S.A. Pre-filled syringe for unitary dose
DE4016126A1 (en) * 1990-04-17 1991-10-24 Coster Tecnologie Speciali Spa DEVICE FOR TRANSNASAL OR ORAL ADMINISTRATION OF MEDICATIONS OR THE LIKE
GB9125699D0 (en) * 1991-12-03 1992-01-29 Glaxo Group Ltd Device

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DE69916644D1 (en) 2004-05-27
WO2000024523A1 (en) 2000-05-04
FR2784969B1 (en) 2001-01-19
EP1124646A1 (en) 2001-08-22
CN1324273A (en) 2001-11-28
FR2784969A1 (en) 2000-04-28
US6450216B1 (en) 2002-09-17
JP2002537873A (en) 2002-11-12

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