EP1123124A2 - Procede pour reconstituer un fluide d'injection, et appareil d'injection pour mettre en oeuvre ledit procede - Google Patents

Procede pour reconstituer un fluide d'injection, et appareil d'injection pour mettre en oeuvre ledit procede

Info

Publication number
EP1123124A2
EP1123124A2 EP99953764A EP99953764A EP1123124A2 EP 1123124 A2 EP1123124 A2 EP 1123124A2 EP 99953764 A EP99953764 A EP 99953764A EP 99953764 A EP99953764 A EP 99953764A EP 1123124 A2 EP1123124 A2 EP 1123124A2
Authority
EP
European Patent Office
Prior art keywords
injection device
housing
threaded rod
actuator
injection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99953764A
Other languages
German (de)
English (en)
Inventor
Jochen Gabriel
Ulf Polzin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
B D Medico Sarl
Original Assignee
Medico Development Investment Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medico Development Investment Co filed Critical Medico Development Investment Co
Publication of EP1123124A2 publication Critical patent/EP1123124A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2006—Having specific accessories
    • A61M2005/202—Having specific accessories cocking means, e.g. to bias the main drive spring of an injector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/206—With automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/1782—Devices aiding filling of syringes in situ
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31561—Mechanically operated dose setting member using freely adjustable volume steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/31573—Accuracy improving means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
    • A61M5/31595—Pre-defined multi-dose administration by repeated overcoming of means blocking the free advancing movement of piston rod, e.g. by tearing or de-blocking

Definitions

  • the invention relates to a method for reconstituting an injection liquid, and an injection device for performing such a method.
  • an injection device with a housing and a threaded rod, which is provided with an external thread, is used to squeeze liquid out of a liquid container, and which is arranged in the housing in an axially displaceable but non-rotatable manner.
  • the threaded rod is used to first insert an injection needle during the injection process and then to inject liquid through this needle.
  • this object is achieved by an injection device according to claim 1.
  • This gives the possibility of rotating the actuator in the first position relative to the axially displaceable part, and thereby influencing the axially displaceable part in a certain way, and one can after completion of this process, bring the actuator into the second position, in which this rotation is blocked and the actuator is forced to follow the movements of the axially displaceable element, the actuator in the second position being particularly preferably locked with the axially displaceable element becomes.
  • This enables two different operating modes of such an injection device, e.g. the first operating mode can be reserved for the medical specialist (doctor, nurse), and only the second operating mode is released for the patient, and the patient e.g. cannot return to the first operating mode from the second operating mode. This is an important safety feature in order to avoid incorrect operation of such an injection device by the patient.
  • an injection device has the advantage that a movement of the threaded rod in the proximal direction and in the distal direction is made possible by a relative rotary movement between the external thread of the threaded rod and the internal thread of the actuator, such as that for example is necessary for the reconstitution of an injection liquid, while an axial displacement of the actuator relative to the threaded rod allows the teeth of the internal thread (the actuator) to slide along the teeth of the external thread and thus enables simple and easy-to-understand handling by the patient during the injection.
  • a method according to the invention for the reconstitution of an injection liquid is the subject of claim 38 and a method according to the invention for carrying out an injection is the subject of claim 41.
  • switching to single injection results in a sensible and easily understandable process which avoids operating errors.
  • the method of claim 41 has the advantage that The needle can be inserted by means of a "mechanical drive” and that the pressure increase in the cartridge required for the "hydraulic drive” does not have to be effected until the needle has already been inserted, so that no or only a slight loss of fluid can occur due to the pressure increase .
  • FIG. 1 is an external view of an injection device according to the invention in the state as it leaves the factory, ie before the reconstitution of the lyophilisate,
  • FIG. 2 shows an external view of the injection device in the state after the preparation of the device for injections, that is to say after the reconstitution of the lyophilisate, and after setting an injection dose of approximately 20 units
  • FIG. 3 shows a longitudinal section through the injection device of FIG. 1,
  • FIG. 4 shows a longitudinal section analogous to FIG. 3, but perpendicular to the plane of FIG. 3,
  • FIG. 5 shows a longitudinal section through a threaded rod as used in the injection device, seen in the direction of the arrows V-V of FIG. 7,
  • FIG. 6 is a plan view of the threaded rod of FIG. 5, seen in the direction of arrow VI of FIG. 7,
  • FIGS. 5 and 6 are plan views of the upper end of the threaded rod according to FIGS. 5 and 6,
  • FIGS. 1 to 10 is a spatial representation of a trigger member used in the injection device according to FIGS. 1 to 10 with locking member,
  • 11 is a spatial representation of an actuator used in the injection device
  • FIG. 12 shows an enlarged detail from FIG. 4,
  • FIG. 13 shows a representation analogous to FIG. 12, but in the position of the parts after completion of a reconstitution
  • FIG. 17 shows a section through the connecting part of FIG. 16, with which a container with a lyophilized drug is connected
  • FIG. 21 is an enlarged view of detail XXI of FIG. 19,
  • 25 is an illustration for explaining the first section of the tensioning process in which the injection needle is displaced by the insertion path into the interior of the housing
  • 26 is an enlarged view of detail XXVI of FIG. 25,
  • FIG. 27 is an illustration for explaining the second section of a tensioning process, in which the injection needle remains in the position according to FIG. 25 and the actuating button is shifted further in the distal direction in accordance with the set dose,
  • FIG. 29 shows a representation analogous to FIG. 27, but in a plane perpendicular to FIG. 27,
  • FIG. 32 is an enlarged view of the central parts of the injection device in the tensioned state before an injection, 33 shows a representation analogous to FIG. 32 in the initial phase of an injection,
  • FIG. 34 shows a representation analogous to FIG. 33, the injection needle being fully inserted
  • FIGS. 32 to 34 shows a representation analogous to FIGS. 32 to 34 after the completion of an injection
  • FIG. 36 is an illustration showing how the device is prepared for injections after reconstitution, in a longitudinal section analogous to FIG. 3, and
  • FIG. 37 shows an illustration in the same position as in FIG. 36, but in a sectional plane offset by 90 ° to this.
  • FIG. 1 shows an injection device 40 in the state in which it leaves the manufacturer's factory. It looks something like an oversized fountain pen and has an elongated, tubular housing 42. At the top there is an actuation button 44, and at the bottom, where a cover cap 46 is shown, a needle is attached before use, cf. Fig. 24.
  • distal and proximal are used as follows: Proximal: The side facing the patient, that is to say the side with the needle (in FIG. 1 below). Distal: The side facing away from the patient, that is to say the side with the needle (in FIG. 1 below).
  • a metering wheel 52 On the central part of the housing 42, a metering wheel 52 is rotatably but axially immovable. It has an internal thread 54 (FIG. 3) which engages in an external thread (steep thread) 56 (FIG. 2) of a dose setting part 58 which is guided axially displaceably but non-rotatably in longitudinal grooves 59, 59 'of the housing 42, cf. Fig. 20.
  • the dose setting part 58 If the dosing wheel 52 is rotated, the dose setting part 58 is correspondingly axially displaced, as a comparison of Figs. 1 and 2 shows, i.e. FIG. 1 shows the dose setting "0", recognizable by the "0" shown at 60, and FIG. 2 shows the dose setting "20". So you can adjust the injection dose by turning the dosing wheel 52, and if this is not changed, this set dose is injected with each injection. This is known as a "steady dose injector". If desired, the dosage can
  • a resilient clip 62 which serves to trigger an injection, is arranged on the dose setting part 58. At its free end it has a projection 64 which projects towards the device 40 and which lies opposite a latching opening 66 of the dose setting part 58. As a comparison of FIGS. 1 and 2 shows, this opening 66 is displaced in the distal direction when the dose is increased.
  • FIG. 1 shows a rotating arrow 68 at the distal end, that is to say at the top, to indicate that in the state according to FIG. 1 the actuating button 44 can be turned in both directions. Alternatively, the button 44 can also be moved in the direction of an arrow 70 in the distal direction.
  • FIG. 3 is a longitudinal section through the injection device 40 of FIG. 1, and FIG. 4 is an analogous longitudinal section, but in a plane perpendicular to FIG. 3.
  • a transparent cartridge holder 74 which is composed of a proximal part 76 and a distal part 78 and holds the cartridge 50 in its interior.
  • the parts 76, 78 are connected to one another by a micro-catch 77, which is shown on an enlarged scale in FIG. 30. It allows a simple and highly precise adjustment of the length of the cartridge holder 74 to adapt to the cartridge 50 and its filling quantity.
  • the part 78 has a radial projection 80 which is guided in a longitudinal groove 82 of the housing 42 and can be displaced there between two stops 84, 86. As a result, the cartridge holder 74 cannot be rotated relative to the housing 42 and can only be axially displaced to a limited extent. 21 shows the projection 80 on an enlarged scale.
  • the liquid 49 in the cartridge 50 is only a solvent.
  • An active ingredient must be added to this solvent, which is usually present as a lyophilized product in a container, cf. the container 224 in FIG. 18 with the lyophilisate 226. How this happens is described in detail below.
  • This is called the reconstitution of the liquid 49, or put another way: its conversion into a drug.
  • the injection device must be "prepared” accordingly before it can be used by the patient.
  • the reason for the separate storage of solvent and active ingredient is that the reconstituted liquid has a limited shelf life, usually only two to three weeks.
  • the reconstitution is usually carried out by specialist staff (nurse, doctor), but can also be carried out by a trained patient.
  • the cartridge 50 has, in the usual way, a rubber membrane 88 at its proximal end, which can be pierced by a needle, cf. Fig. 25. At its distal end it has a rubber washer 90 to which the proximal end of a threaded rod 92 is fastened, which is shown enlarged in FIGS. 5 to 9 and which - because of its double function - can also be referred to as a toothed rack.
  • the proximal end of the threaded rod 92 is buttoned into a complementary recess 96 of the rubber piston 90 with a mushroom-like projection 94, cf. 5 and 6. This can be done with the help of micro-detent 77.
  • FIG. 7 shows a plan view of the distal end 98 of the threaded rod 92.
  • This has an essentially circular cross section, with two opposite longitudinal grooves 100, 102 for axial longitudinal guidance. These are guided in radially inwardly projecting projections 104 (FIGS. 3 and 15) of the distal part 78 of the cartridge holder 74, which itself is secured against rotation by its radial projection 80, so that the piston rod 92 does not rotate relative to the housing 42 - but is only axially displaceable.
  • the teeth 104 of the threaded rod 92 are designed as external threads, but have the sawtooth shape which is characteristic of a toothed rack, cf. Fig. 8, i.e. the proximal part 106 of a tooth 104 has a flat pitch, while the distal part 108 has a large pitch.
  • a proximal part 110 (FIG. 6) of the rack 92 is solid, and a distal part 112 has a cylindrical recess 114 on the inside, which, however, does not extend radially to the longitudinal grooves 100, 102.
  • a pin 116 (FIGS. 5, 8, 9) is guided axially displaceably in the recess 114. This has at its proximal end two resilient parts 118 which project radially outwards through two diametrically opposite openings 120, 121 of the grooves 100, 102, cf. Fig. 9, from which the shape of the projections 118 and the position of the openings 120, 121 is clear. These lie at the proximal end 122 of the recess 114.
  • the distal end of the pin 116 has a recess 124 (FIG. 8) in which a green signal body 126 is releasably locked with a resilient pin 128.
  • a green signal body 126 is releasably locked with a resilient pin 128.
  • the locking teeth 138, 139 are not in engagement with the teeth 104, so that the rack 92 can be axially displaced by the parts 136, 137 without hindrance.
  • the resilient parts 136, 137 can, however, be moved radially inward for engagement with the rack 92 by a corresponding cam control.
  • Corresponding cams 140, 142 are located on the inside of the housing 42.
  • An element 144 which is axially displaceable in the housing 42 and is depicted in three dimensions in FIG.
  • frustoconical section 146 at its proximal end, which also acts as a cam and, after completing an injection, compresses the resilient parts 136, 137 and engages the rack 92, cf. 31 and 35, also after completion of the reconstitution, cf. Fig. 13.
  • the element 144 which is axially displaceable in the housing 42, has two on its outer side 148 Longitudinal grooves 150, 151, which are axially guided in corresponding projections 152, 153 of the housing 42. Furthermore, it has a resilient latching hook 156 with a radially outwardly projecting projection 158, which can engage in the recess 66 (FIG. 1) of the dose setting part 58, as shown, for example, in FIG. 36. In injection mode, i.e. after reconstitution, it serves as a tension and release link.
  • the element 144 axially displaceable in the housing 42 is held in the position according to FIGS. 3 and 4.
  • the element 144 In its proximal area, the element 144 is pierced by two diametrically opposed longitudinal grooves 162, 164, which are guided in the longitudinal direction according to FIG. 4 on the cams 140 and 142 fixed to the housing and during injection with their distal ends 162 ', 164' against them Cams come into contact, cf. Fig. 35.
  • the element 144 axially displaceable in the housing 42 has an inwardly projecting annular shoulder 166 in the central region of its inside, cf. 12 and 13.
  • the distal end region of its inside 168 it has radially inwardly projecting projections 170, one of which is shown in FIG. 10.
  • An adjusting member 174 is arranged in the inner side 168 of the element 144 and is shown in spatial form in FIG. 11. Its distal section 176 has the shape of a cylindrical tube, which is locked via radial recesses 178 at its distal end with radial projections 180 of the actuating button 44 and therefore forms a unit with the latter in the assembled state.
  • the threaded rod 92 is axially guided in this tube 176.
  • the tube 176 merges into a part 182 with two resilient latching hooks 184, 186, which are each provided on their inside with latching teeth 184 ', 186' in the form of threaded sections of an internal thread, which are connected to the external thread in the form of the teeth 104 in the Rack 92 are approximately complementary, as shown in FIG. 11.
  • the threaded rod 92 can be axially displaced by rotating the actuator 174 (using the rotary knob 44). But you can also move the actuator 174 in the direction of arrow 70 relative to the threaded rod 92, the locking teeth 184 ', 186' resiliently slide over the teeth 104 of the threaded rod 92. Because of the shape of the teeth 104, this is only possible in the distal direction (arrow 70).
  • the part 182 of the actuator 174 has two guide parts 188, 190 with an essentially circular-cylindrical outline shape.
  • Stop parts 192, 194 with a detent recess 192 'and 194' are offset by 90 ° to the stop parts 188 ', 190'.
  • the stop parts 188 ', 190', 192, 194 also serve as abutments for the proximal end of an injection spring 200, the distal end of which rests against an end cap 202, which in the manner shown is snapped into the distal end of the housing 42 and a guide for the distal end of the tube 176 forms.
  • the actuator 174 can be freely rotated relative to the housing 42, as is necessary for the reconstitution. 12 shows this state again on a greatly enlarged scale. It can also be seen that the resilient parts 136, 137 are sprung radially outward, because they do not bear against the cams 140, 142 of the housing 42, nor against the truncated cone 146 of the element 144 axially displaceable in the housing 42.
  • the inner parts of the injection device 40 are brought into a position which is shown in FIG. 13.
  • the comparison with FIG. 12 immediately shows the differences: the actuator 174 is in the same position as in FIG. 12, but the element 144 which is axially displaceable in the housing 42 is in the proximal direction up to its stop on the cam 140, 142 moved so that its hollow truncated cone 146 now abuts the inclined surfaces 136 "and 137" of the parts 136, 137 and presses the latter against the rack 92, whereby a positive connection between the rack 92 and the part 78 of the cartridge holder 74 is produced.
  • the inner projections 170 of the element 144 axially displaceable in the housing 42 are now firmly engaged in the recesses 192 ', 194' of the stop parts 192, 194, so that the actuator 174 is permanently locked in place with the element 144 axially displaceable in the housing 42 and only can still move along with this. Since the element 144 is prevented from rotating by the cams 140, 142, which protrude into the grooves 162, 164, the actuator 174 can no longer be rotated in this position.
  • the position of the parts according to FIG. 13 is achieved in that after reconstitution in the device according to FIGS. 1, 3 and 4, the actuating button 44 is pulled up in the direction of arrow 70 until the projections 170 into the latching recesses 192 ', 194 'click into place. The device is then triggered for the first time by pressing clip 62. This is described in more detail below with reference to FIGS. 36 and 37.
  • An adapter 210 which is shown in FIG. 16, is used for the reconstitution. It has an approximately cylindrical housing 212 in which a cannula container 214 is fastened, e.g. by pressing, gluing, or welding. This has an upper flange 215 which projects radially beyond the upper edge of the housing 212.
  • a standard cannula holder 216 is attached in a suitable manner with its cannula 218 in the cannula container 214.
  • the cannula container 214 is sterile closed at the top with a peel film 220, which is releasably attached to the flange 215.
  • an internal thread 217 is provided in the cannula carrier 216 for attachment to the injection device 40.
  • the cannula holder 216 and the cannula 218 can therefore be a standard component here, as is used in large quantities for injections, which makes the manufacture of the adapter 210 less expensive.
  • the widened flange 215 ensures a secure connection with the peel film 220.
  • a conventional container 224 which contains a lyophilisate 226, is pressed with its lid 227 into the lower recess 228 of the housing 212 and latches there on a latching projection 230. In doing so, it pushes the rubber piston 222 upwards, and this is pierced, as shown, on a thin central part 222 'from the lower end of the cannula 218, which subsequently pierces a rubber membrane 233 in the cover 227.
  • the film 220 is then pulled off, and the arrangement according to FIG. 17, like an injection needle, can be screwed onto the injection device 40 by means of the internal thread 217, cf. 18, the upper end of the cannula 218 in FIGS. 16 and 17 penetrates the rubber membrane 88 of the cartridge 50 and forms a connection therefrom to the container 224.
  • the actuation button 44 is now turned in the direction of arrow 234, that is to say - if one looks at button 44 in the direction of arrow 236 - counterclockwise.
  • the threaded rod 92 is displaced in the proximal direction to an end position, which is shown in FIG. 19, displaces the rubber piston 90 in the proximal direction, and presses the liquid 49 out of the cartridge 50 through the cannula 218 into the container 224, where the lyophilizate 238 is reconstituted as shown in FIG. 19.
  • the pin 116 abuts with its projections 118 against the parts 104 of the cartridge holder 74 and is displaced in the distal direction, as also shown in FIG. 21.
  • the upper end of the pin 116 moves in the manner shown in FIG. 20 and engages with its projections 130 in the groove 132, so that the pin 116 is locked in this position according to FIGS. 20 and 21.
  • the signal body 126 thereby protrudes from the distal end of the threaded rod 92, cf. Fig. 20.
  • the injection liquid 238 is now reconstituted and can be sucked back into the cartridge 50. This is shown in FIG. 22.
  • the injection device 40 is turned upside down, and the threaded rod 92 is screwed back by turning the actuating button 44. As viewed in the direction of arrow 236, the rotary knob 44 is turned clockwise.
  • the rubber piston 90 Since the rubber piston 90 is connected to the threaded rod 92, cf. 5 and 6, it moves in the distal direction, that is to say downward in FIG. 22, and in doing so sucks the reconstituted liquid 238 out of the container 224 through the cannula 218 into the cartridge (cartridge) 50.
  • the signal body 126 (made of elastic plastic) is pressed through an opening 242 (FIG. 3) of the actuation button 44 and snaps there with it Ring groove 246 permanently on.
  • the user is constantly reminded that this injection device contains reconstituted injection liquid 238 which is intended for immediate consumption.
  • 23 shows the signal body 126 on a greatly enlarged scale.
  • the connecting member 210 and container 224 are then unscrewed.
  • the actuator 174 is displaced in the distal direction relative to the - fixed - element 144, the inner projections 170 of the element 144 firmly latching into the recesses 192 ', 194' of the stop parts 192, 194, cf. Fig. 13.
  • the cartridge holder 74 is pulled along in that the piston 90, which is connected to the piston rod 92, comes to a stop against the projections 104 of the part 78 and thereby pulls the cartridge holder 74 in the distal direction.
  • the projections 104 can also snap into a groove (not shown) in the piston rod 92, as long as the piston 90 is in the position shown in FIG. 36.
  • the device 40 After reaching the position according to FIGS. 36 and 37, the device 40 is released by pressing the clip 62, and the position according to FIG. 24 is then obtained in which the parts 136, 137 are kept closed by the truncated cone 146 of the element 144 .
  • a cannula 250 is screwed with its cannula carrier 252 onto the thread at the proximal end of the cartridge holder 74, cf. 24, and by turning the dosing wheel 52, the desired injection dose is set, as shown in FIG. 2 by way of example.
  • the rotation of the metering wheel 52 is symbolized in FIG. 24 by an arrow 254.
  • FIG. 13 shows the position of the injection device 40 according to FIG. 24 on an enlarged scale, and as described in detail there, the resilient parts 136, 137 are held in this position by the hollow cone 146 at the proximal end of the element 144 in contact with the threaded rod 92 .
  • the injection device 40 After preselection of the injection dose by turning the dosing wheel 52, cf. 2, the injection device 40 is tensioned, that is to say prepared for an injection. This is done by pulling the actuation button 44 in the distal direction, as indicated in FIG. 25 by an arrow 256.
  • FIG. 25 and 26 show the first part of the tensioning process.
  • the cannula 250 is pulled completely into the interior of the housing 42 so that it is no longer visible to the patient.
  • the parts 136, 137 slide with their sections 270, 272 (FIG. 33) between the cams 140, 142 on the inside of the housing 42 and are kept closed by them.
  • the radial projection 80 of the cartridge holder comes into abutment against the distal end 84 of the groove 82, which prevents further displacement of the cartridge holder 74 in the distal direction.
  • the actuation button 44 is pulled further in the distal direction until the element 144, which is axially displaceable in the housing 42, engages with its catch element 158 in the recess 66 of the dose setting part 58.
  • each tooth 104 means a dosing unit X, cf. Fig. 6.
  • FIG. 28 shows that the signal body 126 is pulled out of the recess 124 of the cylindrical pin 116 during this tensioning process and is held in the recess 242 of the actuating button 44. As a result, the signal body 126 remains constantly visible to the user.
  • an injection is now triggered by pressing the clip 62 (arrow 260 in FIG. 31).
  • a body part is symbolically indicated at 262, into which the cannula 250 has already been inserted and the previously set dose 238 'of the liquid 238 has been injected.
  • FIGS. 32 to 35 relate to a) the insertion of the cannula 250, and b) the injection through the inserted cannula 250. These processes can partially overlap.
  • the resilient parts 136, 137 are initially kept closed by the cams 140, 142 of the housing 42, since they have a longer section 270 or 272 which is parallel to the longitudinal axis of the device 40 and which is made up of the complementary straight section 140 'and 142 'The cam 140, 142 gradually slides out, so that the resilient parts 136, 137 are kept closed for approximately the first third of the puncture path and the force F is transmitted directly, ie mechanically, from the rack 92 to the cartridge holder 74. (According to FIG.
  • the force F of the injection spring 200 is transmitted to the rack 92 via the actuator 174.
  • the resilient parts 136, 137 finally slide out of the cams 140, 142 and spread through their spring force, so that the force F from the rack 92 now acts directly on the rubber piston 90.
  • This increases the pressure in the injection liquid 238, which acts like a solid body and continues to transmit the force F to the cannula 250 until the projection 80 of the cartridge holder 74 abuts its proximal stop 86, which ends the puncturing phase, ie the cannula 250 then has the position according to FIG. 31.
  • the resilient parts 136, 137 are open in the position of FIG. 34, so that the toothed rack 92 can be displaced relative to the cartridge holder 74 independently of the latter.
  • the rack 92 displaces the piston 90 in the (now stationary) container 50 and presses the quantity of liquid 238 'set with the metering wheel 52 out of the container 50, cf. Fig. 31.
  • the element 144 which is axially displaceable in the housing 42, reaches its proximal end division according to FIG. 35, thereby pressing with its hollow truncated cone 146 onto the oblique portions 136 ", 137" of the resilient parts 136, 137, and thereby bringing the latter back again Engagement with the rack 92 so that a new clamping process can begin, as described in Fig. 25 ff.
  • the cannula 250 is initially pierced by a mechanical force transmission (via the parts 136, 137) and then by a hydraulic force transmission, which results in a high dosing accuracy, since none occurs during the mechanical force transmission, which leads to the puncture of the cannula 250 Liquid can leak out of it. Liquid that may emerge from the cannula 250 during the subsequent hydraulic power transmission is injected into the body.
  • the cannula 250 is pulled out of the body part 262 and replaced by a new cannula, which is covered in a sterile manner with a closure cap 46 (FIG. 2). This cap is only removed before the next injection.
  • one of the resilient parts 136, 137 would suffice for the mechanical power transmission to the cartridge holder 74. Except for the injection spring 200 and the cartridge 50, all parts can be made of a suitable plastic, and therefore the device can be easily recycled.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Loading And Unloading Of Fuel Tanks Or Ships (AREA)

Abstract

L'invention concerne un appareil d'injection comportant un boîtier (42) conçu pour recevoir un contenant (50) renfermant un liquide. Un élément (92) coulissant axialement, logé dans le boîtier (42), sert à agir sur ledit contenant (50). Un élément d'actionnement (174) a pour fonction d'influer sur la position, par rapport à lui, de l'élément coulissant axialement (92). Un élément (144) est placé dans le boîtier (42) de manière à pouvoir coulisser axialement mais de manière à être pratiquement bloqué en rotation, par rapport au boîtier (42). L'élément d'actionnement (174) peut prendre au moins deux positions différentes par rapport à cet élément (144). Dans une première position (Fig. 12), il peut tourner par rapport audit élément (144) et, dans une deuxième position (Fig. 13), il est bloqué en rotation par rapport à cet élément (144). L'invention concerne en outre un procédé pour reconstituer un liquide d'injection et un procédé pour effectuer une injection.
EP99953764A 1998-10-21 1999-10-09 Procede pour reconstituer un fluide d'injection, et appareil d'injection pour mettre en oeuvre ledit procede Withdrawn EP1123124A2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1998218721 DE29818721U1 (de) 1998-10-21 1998-10-21 Injektionsgerät
DE29818721U 1998-10-21
PCT/EP1999/007587 WO2000023133A2 (fr) 1998-10-21 1999-10-09 Procede pour reconstituer un fluide d'injection, et appareil d'injection pour mettre en oeuvre ledit procede

Publications (1)

Publication Number Publication Date
EP1123124A2 true EP1123124A2 (fr) 2001-08-16

Family

ID=8064163

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99953764A Withdrawn EP1123124A2 (fr) 1998-10-21 1999-10-09 Procede pour reconstituer un fluide d'injection, et appareil d'injection pour mettre en oeuvre ledit procede

Country Status (5)

Country Link
EP (1) EP1123124A2 (fr)
JP (1) JP2002527210A (fr)
CA (1) CA2356614A1 (fr)
DE (2) DE29818721U1 (fr)
WO (1) WO2000023133A2 (fr)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001072354A2 (fr) * 2000-03-28 2001-10-04 Elan Pharma International Limited Dispositif servant a mesurer un volume de medicament
DE10034270A1 (de) 2000-07-14 2002-02-14 Disetronic Licensing Ag Vorratsbehältnis mit einer Dosiereinrichtung zur dosierten Abgabe eines injizierbaren Produkts an ein Injektionsgerät
DE10163328B4 (de) 2001-07-30 2005-08-11 Tecpharma Licensing Ag Verabreichungsgerät mit Verdrehsicherung
DE10163327A1 (de) 2001-07-30 2003-02-27 Disetronic Licensing Ag Reservoirmodul mit Kolbenstange
EP1558307A1 (fr) * 2002-04-17 2005-08-03 Tecpharma Licensing AG Dispositif d'administration d'un produit injectable
DE10320225A1 (de) * 2003-05-05 2004-12-02 L + N Plast-Vertriebs Gmbh Mehrweg-Betätigungsvorrichtung für eine sterile Spritze
DE10322261B3 (de) * 2003-05-16 2004-09-23 Witeg Labortechnik Gmbh Betätigungsvorrichtung, insbesondere für Dispenser
DE10342058B4 (de) * 2003-09-11 2007-10-25 Tecpharma Licensing Ag Verabreichungsvorrichtung für ein injizierbares Produkt mit einer Auslösesicherung
IL157984A (en) 2003-09-17 2015-02-26 Dali Medical Devices Ltd Automatic needle
IL160891A0 (en) * 2004-03-16 2004-08-31 Auto-mix needle
DE102004060145B4 (de) 2004-12-14 2016-07-14 Tecpharma Licensing Ag Zahneingriffsteuerung
DE102005008065A1 (de) * 2005-02-22 2006-08-24 Tecpharma Licensing Ag Zahneingriff mit ungleicher Teilung
GB2433032A (en) 2005-12-08 2007-06-13 Owen Mumford Ltd Syringe with dose adjustment means
DE102006038121A1 (de) * 2006-08-14 2008-02-21 Tecpharma Licensing Ag Injektionsvorrichtung mit Echtzeitanzeige
DE102006038101A1 (de) * 2006-08-14 2008-02-21 Tecpharma Licensing Ag Injektionsvorrichtung mit Klauensicherung
WO2008047372A2 (fr) 2006-10-19 2008-04-24 Elcam Medical Agricultural Cooperative Association Ltd. Dispositif d'injection automatique
DE102007004211A1 (de) 2007-01-27 2008-07-31 Lts Lohmann Therapie-Systeme Ag Einweginjektor mit mindestens einem Zughaken
DE102007008369A1 (de) * 2007-02-16 2008-08-21 Lts Lohmann Therapie-Systeme Ag Einweginjektor mit mindestens einem zentralen Zugstab
DE102007018868A1 (de) * 2007-04-19 2008-10-23 Lts Lohmann Therapie-Systeme Ag Einweginjektor mit mindestens einem Zughaken und einem Schiebekeilgetriebe zum entsichernden Lösen eines Sperrelements
DE102008003105A1 (de) * 2008-01-01 2009-07-02 Lts Lohmann Therapie-Systeme Ag Einweginjektor mit handbetätigbarem Kolben und einem Zweikammersystem
DE102008003103A1 (de) * 2008-01-01 2009-07-02 Lts Lohmann Therapie-Systeme Ag Einweginjektor mit zweikolbigem Zweikammersystem
DE102008048981A1 (de) 2008-09-25 2010-04-15 Lts Lohmann Therapie-Systeme Ag Injektor und Zwei-Kammer-System mit sterilen Komponenten
DE102008054128A1 (de) 2008-10-31 2010-06-10 Lts Lohmann Therapie-Systeme Ag Injektor und Zwei-Kammer-System mit abdichtendem Behälteradapter
EP2201971A1 (fr) 2008-12-23 2010-06-30 Sanofi-Aventis Deutschland GmbH Dispositif d'administration de médicaments
EP2201970A1 (fr) 2008-12-23 2010-06-30 Sanofi-Aventis Deutschland GmbH Dispositif d'administration de médicaments
US8672896B2 (en) 2009-06-01 2014-03-18 Sanofi-Aventis Deutschland Gmbh Inner housing for a drug delivery device
US8257319B2 (en) 2009-06-01 2012-09-04 Sanofi-Aventis Deutschland Gmbh Drug delivery device inner housing having helical spline
US8585656B2 (en) 2009-06-01 2013-11-19 Sanofi-Aventis Deutschland Gmbh Dose setting mechanism for priming a drug delivery device
US9463283B2 (en) 2009-06-01 2016-10-11 Sanofi-Aventis Deutschland Gmbh Dosing mechanism for a drug deliver device
US9623187B2 (en) 2009-06-01 2017-04-18 Sanofi-Aventis Deutschland Gmbh Resettable drug delivery device
US9108007B2 (en) 2009-06-01 2015-08-18 Sanofi-Aventis Deutschland Gmbh Spindle and bearing combination and drug delivery device
US9125994B2 (en) 2009-06-01 2015-09-08 Sanofi—Aventis Deutschland GmbH Drug delivery device with dose dial sleeve rotational stop
US9950116B2 (en) 2009-06-01 2018-04-24 Sanofi-Aventis Deutschland Gmbh Dose setting mechanism for priming a drug delivery device
US8728043B2 (en) 2009-06-01 2014-05-20 Sanofi-Aventis Deutschland Gmbh Drive mechanism for a drug delivery device
US10034982B2 (en) 2009-06-01 2018-07-31 Sanofi-Aventis Deutschland Gmbh Spindle for a drug delivery device
US9199040B2 (en) 2009-06-01 2015-12-01 Sanofi-Aventis Deutschland Gmbh Drug delivery device last dose lock-out mechanism
US9345840B2 (en) 2009-06-01 2016-05-24 Sanofi-Aventis Deutschland Gmbh Drug delivery dose setting mechanism with variable maximum dose
US8974423B2 (en) 2009-06-01 2015-03-10 Sanofi-Aventis Deutschland Gmbh Resettable drug delivery device
US9238106B2 (en) 2009-06-01 2016-01-19 Sanofi-Aventis Deutschland Gmbh Dose setting mechanism for priming a drug delivery device
US9457150B2 (en) 2009-06-01 2016-10-04 Sanofi-Aventis Deutschland Gmbh Biasing mechanism for a drug delivery device
JP5385074B2 (ja) * 2009-09-29 2014-01-08 テルモ株式会社 薬剤注入具
GB0918145D0 (en) 2009-10-16 2009-12-02 Owen Mumford Ltd Injector apparatus
US8535268B2 (en) 2010-12-22 2013-09-17 Alcon Research, Ltd. Device for at least one of injection or aspiration
AU2012210170B2 (en) 2011-01-24 2016-09-29 Elcam Medical Agricultural Cooperative Association Ltd. Injector
JP5734752B2 (ja) * 2011-05-31 2015-06-17 株式会社吉野工業所 カートリッジ式注射器
EP3498319A1 (fr) 2015-01-16 2019-06-19 Becton Dickinson France Système de stockage et de distribution de médicaments pour récipients pré-remplis

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3638984C3 (de) 1986-11-14 1993-11-18 Haselmeier Wilhelm Fa Injektionsgerät
DE3715258C2 (de) * 1987-05-08 1996-10-31 Haselmeier Wilhelm Fa Injektionsgerät
DE3900926C2 (de) * 1988-02-08 1999-05-12 Disetronic Licensing Ag Spritzenförmiges Injektionsgerät und Injektionsgerätebaukasten
US4913699A (en) * 1988-03-14 1990-04-03 Parsons James S Disposable needleless injection system
DK17890A (da) * 1990-01-22 1991-07-23 Novo Nordisk As Fremgangsmaade og apparat til opblanding og injicering af et laegemiddel
JPH0531190A (ja) * 1991-07-26 1993-02-09 Seikagaku Kogyo Co Ltd 注射具
US5383865A (en) * 1993-03-15 1995-01-24 Eli Lilly And Company Medication dispensing device
ZA941881B (en) * 1993-04-02 1995-09-18 Lilly Co Eli Manifold medication injection apparatus and method
US5472022A (en) * 1993-11-02 1995-12-05 Genentech, Inc. Injection pen solution transfer apparatus and method
EP1228777B1 (fr) * 1994-05-30 2003-10-29 B D Medico S.a.r.l. Dispositif d'injection
DE29515752U1 (de) * 1995-10-04 1995-11-30 Hoechst Ag, 65929 Frankfurt Halter für Spritzenzylinder mit Injektionskanülenschutzhülse
AU726244B2 (en) * 1996-01-11 2000-11-02 Duoject Medical Systems Inc. Delivery system for pharmaceuticals packed in pharmaceutical vials
GB9611562D0 (en) * 1996-06-03 1996-08-07 Applied Research Systems Device
ATE251479T1 (de) * 1996-07-05 2003-10-15 Disetronic Licensing Ag Injektionsgerät zum injizieren von flüssigkeit
EP0848624B1 (fr) * 1996-07-05 2005-10-26 Tecpharma Licensing AG Appareil pour l'injection de liquide

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO0023133A2 *

Also Published As

Publication number Publication date
DE19948988A1 (de) 2000-04-27
JP2002527210A (ja) 2002-08-27
WO2000023133A3 (fr) 2000-08-10
DE29818721U1 (de) 2000-03-02
CA2356614A1 (fr) 2000-04-27
WO2000023133A2 (fr) 2000-04-27

Similar Documents

Publication Publication Date Title
EP1123124A2 (fr) Procede pour reconstituer un fluide d'injection, et appareil d'injection pour mettre en oeuvre ledit procede
EP1557189B1 (fr) Appareil d'injection
EP1263387B1 (fr) Procede servant a la reconstitution d'un liquide pour injection et appareil pour injection servant a l'execution d'un tel procede
EP0581788B1 (fr) Dispositif d'injection
EP1000631B1 (fr) Appareil d'injection
EP1833535B1 (fr) Dispositif d'administration d'une dose de produit fluide pourvu d'un entrainement a barre de torsion
EP0525525B1 (fr) Injecteur
EP1452197B1 (fr) Dispositif d'injection
EP1228777B1 (fr) Dispositif d'injection
DE69214670T2 (de) Automatische, stiftförmige spritze
EP1926514A1 (fr) Dispositif d'injection à accouplement à glissement à deux voies
EP1965845A1 (fr) Dispositif d'injection doté d'un organe de dosage ou d'affichage a superposition axiale
EP0957958B1 (fr) Dispositif de rappel automatique de la canule de seringues d'injection
AT511259A2 (de) Injektionsspritzenkopf, auspresseinheit sowie daraus gebildete injektionsspritze
DE202008014334U1 (de) Injektionsgerät
DE202014001136U1 (de) Injektionsgerät
EP3102256B1 (fr) Dispositif d'injection
AT517801B1 (de) Injektionsvorrichtung, insbesondere Autoinjektor
CH713129A2 (de) Verbindungsmechanismus für Zusatzmodul.
EP1262416B1 (fr) Conteneur destiné à recevoir et à distribuer une matière fluide
WO2024042188A1 (fr) Auto-injecteur amélioré
WO2024110631A1 (fr) Unité d'entraînement pour une seringue médicale, seringue dotée d'une telle unité d'entraînement et auto-injecteur

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20010207

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: B D MEDICO S.A.R.L.

17Q First examination report despatched

Effective date: 20040210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20040501