EP1117353A1 - Endoprothese tubulaire - Google Patents

Endoprothese tubulaire

Info

Publication number
EP1117353A1
EP1117353A1 EP99955729A EP99955729A EP1117353A1 EP 1117353 A1 EP1117353 A1 EP 1117353A1 EP 99955729 A EP99955729 A EP 99955729A EP 99955729 A EP99955729 A EP 99955729A EP 1117353 A1 EP1117353 A1 EP 1117353A1
Authority
EP
European Patent Office
Prior art keywords
prosthesis
band
webs
prosthesis according
axial direction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99955729A
Other languages
German (de)
English (en)
Inventor
Thomas Schmitz-Rode
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP1117353A1 publication Critical patent/EP1117353A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/88Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91508Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other the meander having a difference in amplitude along the band
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91525Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other within the whole structure different bands showing different meander characteristics, e.g. frequency or amplitude
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91533Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
    • A61F2002/91541Adjacent bands are arranged out of phase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155Adjacent bands being connected to each other
    • A61F2002/91558Adjacent bands being connected to each other connected peak to peak

Definitions

  • the invention relates to a tubular endoprosthesis for implantation in a hollow organ of the human or animal body, an outer circumferential surface of the prosthesis being formed by a helically wound band.
  • a helically wound band which consists of links arranged one behind the other in the longitudinal direction of the belt and connected to one another, which can be extended in the longitudinal direction of the belt with a change in shape.
  • Such an endoprosthesis is known for example from WO 98/38945.
  • medical technology usage such are usually made of metal
  • Endoprostheses are also referred to as so-called “stents”. These serve to treat constrictions in hollow organs and, after being pushed to the implantation site, usually using an inflatable balloon catheter, are expanded in order to adhere to the wall of the hollow organ to be shone or to support it Alternatively, the prosthesis can be made from a special nickel-titanium alloy (so-called “memory metal”) for expansion by means of a balloon catheter. With the help of a heat treatment it is achieved that the stent expands on its own when heated from the ambient to the body temperature after leaving the insertion catheter.
  • the individual members have the shape of a V or two trapezoids which are inclined in the opposite direction with their base sides abutting one another.
  • the border of the individual member, which is open per se, is formed in each case by two narrow V-shaped rod elements, the ends of which are connected to one another via webs running in the axial direction of the stent.
  • the helically wound tape here consists of three individual tapes arranged parallel to one another, each of which is kept at a distance from one another by cross webs which are aligned with one another.
  • the overlap in the case of an axial curvature is to be regarded as a disadvantage here, as is the lack of radial extensibility.
  • Stent constructions without a helical structure are known for example from EP 0 221 570 B1 and EP 0 335 341 B1.
  • a stent is described, the lateral surface of which is constructed from longitudinal strips running in the axial direction and straight through and perpendicularly between adjacent longitudinal strips running in the circumferential direction between adjacent longitudinal strips.
  • the webs on opposite sides of a longitudinal strip are offset from one another by half the distance.
  • the rectangular openings formed by two longitudinal strips and two webs are deformed in a diamond shape in the expanded state of the stent, as a result of which an axial
  • the stent construction disclosed in EP 0 335 341 B1 is characterized by a series of cylindrical individual elements which extend obliquely to the longitudinal axis Connecting webs are coupled together.
  • the individual elements can be expanded radially, as a result of which rectangular openings are converted into a diamond shape with simultaneous axial shortening of the stent. Due to the special web connection of the cylindrical individual segments, a curvature in the axial direction is essentially only possible in the connection areas between the individual segments.
  • This known stent cannot adapt to a surface shape of the hollow organs with a curvature smaller than the axial length of an individual section.
  • the invention has for its object to propose a tubular endoprosthesis for implantation in a hollow organ of the human or animal body, which can be expanded easily enough in the radial direction, which has sufficient flexibility in the axial direction also for adaptation to smaller radii of curvature and in the case a greater curvature in the axial direction in these curved areas has a sufficiently large coverage, that is, support of the surrounding body tissue.
  • helix shape as the basic form of the prosthesis design according to the invention has very good flexibility with regard to curvatures in the axial direction of the endoprosthesis, this flexibility is hardly influenced negatively by the webs between adjacent band sections, since the webs allow adjacent band sections to be removed in the axial direction of the prosthesis.
  • the webs provide increased coverage, which leads to improved support of the surrounding body tissue.
  • a stent according to the invention is particularly suitable for curved blood vessel sections or other curved hollow organs such as the biliary system.
  • the limbs are elongated in the longitudinal direction of the prosthesis and each have a slot-shaped opening.
  • a shape permits simple radial expansion of the stent, the openings changing their shape from a slot to a rhombus or a rhombus when the band is elongated. In this way, a large increase in length can be achieved in the longitudinal direction of the band, which ensures a large radial extensibility.
  • the links and the openings are flat-oval. This also avoids sharp corners or edges, so that there is no risk of damage to the body tissue.
  • the invention in a further embodiment provides that the links are connected via webs which extend centrally from the long sides of the links.
  • a tubular endoprosthesis for implantation in a hollow organ of the human or animal body an outer lateral surface of the prosthesis being formed by a helically wound band, which in turn is formed by a meandering band in the plane of the band extending band is formed, in the axial direction of the prosthesis adjacent band sections are connected to one another by webs, which allow removal of adjacent band sections in the axial direction of the prosthesis.
  • the property of the extensibility of the helical tape in this variant is ensured by a meandering course of a smaller tape.
  • the meandering course causes the meanders to have a steeper course in the event of a tensile stress due to a radial expansion of the stent and thus cause an elongation of the band.
  • a good axial curvature of the endoprosthesis according to the invention is also achieved here in that the webs between adjacent turns are designed such that these turns can be removed from one another in the axial direction.
  • the webs preferably have an S-shaped and / or Z-shaped course when viewed from above on the lateral surface of the prosthesis.
  • At least one end section of the end of the prosthesis starting from the last complete link or the last complete meandering loop, has a plurality of turns which shorten in length in accordance with the pitch of the helix.
  • the windings are connected to the links or meanders of the band section adjacent in the axial direction via transverse webs.
  • the prosthesis from a full-surface starting body by removing the material located between the webs and limbs or meandering is made.
  • This material removal can advantageously be carried out with the aid of a computer-controlled laser cutting device.
  • Either the starting body for the production of the endoprosthesis can be tubular, or alternatively it can also be plate-shaped in order to be wound into a tube after the openings have been made and fixed in this form.
  • the endoprosthesis according to the invention expediently consists of metal, which, depending on the application, can also be a so-called “memory metal alloy”.
  • Figure 1 is a development of the jacket of an endoprosthesis, constructed from a helical coil consisting of individual members
  • Figure 2 as Figure 1, but with a helically wound band, which is formed by a meandering band.
  • the endoprosthesis 1 shown in a development in FIG. 1 consists of five band sections A of a band 2, each forming a turn, axially one behind the other. In the cylinder-wound state of the sheath, its first long side 3 abuts the opposite second long side 4.
  • the endoprosthesis 1 can both be made from a plate-shaped starting material, preferably sheet metal, or from a cylindrical starting body, in each case by producing the openings.
  • the helically wound band 2 consists of links 5 which are arranged one behind the other in the longitudinal direction of the band 2 and which are connected to one another.
  • the links 5 are elongated and oval in the direction of the longitudinal axis L of the endoprosthesis 1 and each have a flat-oval opening 6.
  • Links 5 adjacent in the longitudinal direction of the band 2 are each connected to one another by means of a web 7, which extend centrally from the longitudinal sides 8 of the links 5. These webs 7 merge into the longitudinal sides 8 and have a width which is slightly larger than the width of the strips 9 forming the links.
  • the members 5 are deformed as a result of the tensile stress in the longitudinal direction of the band 2 and enclose a diamond-shaped opening in the stretched state.
  • This radial expansion of the endoprosthesis 1 is accompanied by a certain axial shortening.
  • a connection of adjacent band sections A is done with the help of webs 10, which have a Z- or S-shaped shape. These webs 10 connect such links to one another which, viewed in the circumferential direction, are arranged offset from one another by a link 5. As a result, the webs 10 run at an angle to the longitudinal axis of the endoprosthesis 1, which enables the links 5 of adjacent band sections A to be removed. This creates a very high degree of flexibility of the endoprosthesis 1 with respect to curvatures in the axial direction.
  • the webs 10 connected to every fourth link 5 in the longitudinal direction of the band increase the coverage, that is to say, improve the support of the body tissue in the expanded state of the endoprosthesis 1.
  • both end sections 11 of the endoprosthesis 1 are, starting from the last complete member 5, with several in their length corresponding to the slope of the helix shortening turns 12 provided. These windings 12 are connected via crossbars 13 to the links 5 of the band section A adjacent in the axial direction. The connection of the last turn 12 to the last complete link 5 takes place in the middle of the long side 8 of this link 5. The turn 12 with the smallest axial width finally connects laterally to a link 5 like a connecting web 13.
  • the width of both the turns 12 and the Z-shaped or S-shaped webs 10 is less than the width of the strips 9 forming the links 5. This can ensure greater flexibility in these zones, which may be subject to greater deformation.
  • FIG. 2 shows an alternative design of an endoprosthesis 1 ', in which the band 2' does not consist of individual members coupled to one another, but is formed by a narrow band 14 which runs in a meandering manner in the plane of the band 2 '.
  • An elongation of the band 2 'and thus a radial expansion of the endoprosthesis 1' takes place in this case by widening the meander loops while simultaneously axially shortening them by a certain amount.
  • connection of adjacent strip sections A takes place via webs 10 in an analogous manner to that in the exemplary embodiment according to FIG. 1.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Optics & Photonics (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Physics & Mathematics (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne une endoprothèse tubulaire (1) destinée à être implantée dans un organe creux de l'organisme humain ou animal. Une surface extérieure de la prothèse (1) est entourée en spirale d'une bande (2) constituée de maillons (5) assemblés et placés les uns derrière les autres dans le sens longitudinal de la bande (2). Les maillons (5) sont extensibles dans le sens longitudinal de la bande avec déformation. Pour obtenir simultanément une bonne adaptabilité à la courbure axiale, une ductilité radiale élevée et un maintien suffisant du tissu de l'organisme, des sections adjacentes (A) de la bande sont reliées par des segments (10) dans le sens axial de la prothèse (1), ces segments permettant un écartement des sections adjacentes (A) de la bande dans le sens axial de la prothèse (1).-
EP99955729A 1998-09-21 1999-09-20 Endoprothese tubulaire Withdrawn EP1117353A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE29816878U DE29816878U1 (de) 1998-09-21 1998-09-21 Im Schneidverfahren herstellbarer Helixstent
DE29816878U 1998-09-21
PCT/DE1999/002980 WO2000016718A1 (fr) 1998-09-21 1999-09-20 Endoprothese tubulaire

Publications (1)

Publication Number Publication Date
EP1117353A1 true EP1117353A1 (fr) 2001-07-25

Family

ID=8062909

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99955729A Withdrawn EP1117353A1 (fr) 1998-09-21 1999-09-20 Endoprothese tubulaire

Country Status (4)

Country Link
EP (1) EP1117353A1 (fr)
AU (1) AU1260500A (fr)
DE (2) DE29816878U1 (fr)
WO (1) WO2000016718A1 (fr)

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DE19981854D2 (de) 2001-09-13
WO2000016718A1 (fr) 2000-03-30
DE29816878U1 (de) 1998-12-24
AU1260500A (en) 2000-04-10

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