EP1115824A1 - Compositions de nettoyage pour instruments medicaux - Google Patents

Compositions de nettoyage pour instruments medicaux

Info

Publication number
EP1115824A1
EP1115824A1 EP99947599A EP99947599A EP1115824A1 EP 1115824 A1 EP1115824 A1 EP 1115824A1 EP 99947599 A EP99947599 A EP 99947599A EP 99947599 A EP99947599 A EP 99947599A EP 1115824 A1 EP1115824 A1 EP 1115824A1
Authority
EP
European Patent Office
Prior art keywords
composition
present
silicate
phosphate
solid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP99947599A
Other languages
German (de)
English (en)
Other versions
EP1115824B1 (fr
Inventor
Anthony Marston Gibbs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ebiox Ltd
Original Assignee
OPTIDENT Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9820863.0A external-priority patent/GB9820863D0/en
Application filed by OPTIDENT Ltd filed Critical OPTIDENT Ltd
Publication of EP1115824A1 publication Critical patent/EP1115824A1/fr
Application granted granted Critical
Publication of EP1115824B1 publication Critical patent/EP1115824B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/02—Inorganic compounds ; Elemental compounds
    • C11D3/04—Water-soluble compounds
    • C11D3/06—Phosphates, including polyphosphates
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/02—Inorganic compounds ; Elemental compounds
    • C11D3/04—Water-soluble compounds
    • C11D3/08—Silicates
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/168—Organometallic compounds or orgometallic complexes
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/26—Organic compounds containing nitrogen
    • C11D3/30—Amines; Substituted amines ; Quaternized amines
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66—Non-ionic compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66—Non-ionic compounds
    • C11D1/72—Ethers of polyoxyalkylene glycols
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/88—Ampholytes; Electroneutral compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D2111/00—Cleaning compositions characterised by the objects to be cleaned; Cleaning compositions characterised by non-standard cleaning or washing processes
    • C11D2111/10—Objects to be cleaned
    • C11D2111/14—Hard surfaces
    • C11D2111/20—Industrial or commercial equipment, e.g. reactors, tubes or engines

Definitions

  • the present invention concerns compositions for cleaning instruments and the like. More particularly, it is concerned with compositions for removal of body fluid from surgical instruments and other surfaces such as operating tables and instrument trays.
  • the invention relates to compositions for washing such surfaces, and is particularly concerned with an improved method and composition for the removal of body fluids and soils from surgical instruments and similar medical equipment.
  • Blood is the most difficult type of stain to deal with in that it contains complex iron molecules i.e. haemoglobin molecules. Blood stains are difficult to remove because they tend to harden and become fixed by conventional detergent mixtures.
  • a number of chemical methods have tried to reduce staining by the action of haemoglobin on metals and other surfaces. For reasons which are not understood, the iron content within the haemoglobin tends to become more insoluble in the presence of surface active agents.
  • Fats are another type of stain frequently encountered. These are easily solubilised or emulsified by conventional detergents. However, in the presence of iron i.e. haemoglobin which acts as a catalyst, liquid fats can harden. Thus fats in conjunction with blood can be difficult to remove. In this state, inert soils such as surgical lubricants, usually silicones, can become embedded and thus difficult to remove. Similarly, other soils including soluble and semi-soluble carbohydrates can also become bound up.
  • a wide range of surfactant formulations are known for removing body fluid soils. These are varying effectiveness. Apart from body fluid soils, problems arise with the formation of insoluble deposits arising from water and from the presence of metals, such as aluminium which leads to the formation of alumina scale. Iron oxide or rust staining is also a problem which arises from the presence of haemoglobin in blood stains. Certain sequestering agents are commonly used to inhibit scale formation but these may suffer from instability which presents a safety problem as the decomposition products may be harmful or render the sequestering agent ineffective .
  • Conventional surfactants include polyphosphates . These essentially function as sequestering agents for hard water salts ie they act as a water softener. However, such conventional surfactants are not capable of dissolving rust stains, nor are they capable of preventing the formation of alumina scale.
  • Another common cleaning agent is the complexing agent EDTA.
  • EDTA complexing agent
  • This compound can be unstable at high pH, with the breakdown products being corrosive. This agent also has no effect on rust stains.
  • Conventional soil removal systems are generally high pressure high temperature washing machines such as autoclaves. There are other machines which work at lower temperatures for cleaning heat labile equipment. Hand- hot water is used for hand washing instruments and similar equipment.
  • a commonly used method of washing large numbers of surgical instruments is by batch washing or continuous washing in a suitable machine such as an autoclave or the equivalent to a domestic washer. Also certain instruments are cleaned by ultra- sonic equipment containing either a water based cleaning solution or an organic solvent.
  • compositions of the present invention It is an object of the present invention to provide improved cleaning compositions which are capable of removing substantially all contaminating material from surgical instruments. It is also an aim of the invention to provide compositions which are compatible with a wide range of materials encountered in the medical field. It is a further object to provide compositions which are effective at ambient room temperature and/or at elevated temperatures such as those found in hospital washing equipment. It is thus intended that the compositions of the present invention effect substantially complete and safe removal of soiling. It is hence an aim that the compositions of the invention are easy to handle and use and do not in themselves present a health risk.
  • compositions of the present invention may not need a further heat sterilising treatment. According to the present invention there is provided a composition for cleaning medical instruments, the composition comprising by weight:
  • a metal silicate or silicate complex 2.0 to 20.0%; a metal phosphate or polyphosphate, or othophosphoric acid 1.0 to 50.0%; a non-ionic or amphoteric surfactant 1.0 to 15.0% a quaternary ammonium salt 1.0 to 3.0% with the balance of the composition comprising deionised water or a solid bulking agent ; the composition optionally including one or more of : a sequestering agent 0.5 to 3.0%; an oxygen donor 0.1 to 50.0%; an alcohol 5.0 to 25.0%; a polysaccharide 0.01 to 0.50%; cationic surfactant or source of cations 1.0 to 3.0%; and colours, fragrances, and/or anti-foaming agents as required.
  • compositions in a number of ways including physicochemical and chemical transformation or alteration of the soiling to enable removal.
  • These compositions are directly solely towards soil removal from surgical instruments and associated equipment. Soiling in this context refers to all types of contamination usually encountered in such circumstances and ranges from inorganic materials to microbic organisms. In the medical field, the main criterion is safety, followed by effectiveness and ease of use.
  • the compositions of the present invention provide exactly these benefits.
  • the metal cation in the silicate or silicate complex is an alkali metal cation or an ammonium cation. More preferably, the cation is sodium.
  • the silicate complex may be in the form of a meta-silicate, ortho-silicate, thio-silicate, pyro- silicate and other similar complex silicates.
  • the metal phosphate or polyphosphate is present as an alkali metal or ammonium phosphate and the phosphate may be mono-, di- or tribasic.
  • Tetrasodium pyrophosphate is the most preferred phosphate.
  • a liquid formulation there is preferably 1.0 to 10.0% of the phosphate or polyphosphate present, and in the case of solid formulation there is preferably 40.0 to 50.0% present.
  • Orthophosphoric acid may also be used in place of the metal phosphate or polyphosphate.
  • Any conventional non- ionic surfactant may be used in the compositions of the present invention.
  • the surfactant of choice is NP-9 (nonyl phenol ethoxylate) which is available from ICI under the trade name Synperonic N.
  • the non- ionic surfactant of choice is NP-9 because of compatibility with other components and low foam or reduced foaming at elevated temperatures. This is important where both elevated temperatures and pressures are used in surgical instrument washing machines .
  • Amphoteric surfactants may also be used in the compositions of the present invention in the same amounts as for non-ionic surfactants.
  • the type of non-ionic or amphoteric surfactant and the chain length will depend on the reactivity needs of the formulation and may readily be determined by experimentation. It is, however, important for the isoelectric point to be higher than pH7.
  • Carboxylated imidazolenes are the preferred amphoteric surfactants.
  • the quaternary ammonium salt acts as a complexing agent and may be derived from a lower alkyl amine having one or more alkyl substituents each being C 6 or less and a single substituent including an aryl group.
  • the quaternary ammonium salt is lauryl benzyl ammonium chloride, or cetyl trimethyl ammonium bromide, or 1 - aminoethyl , 2-alkylimidazoline .
  • the sequestering agent when present, serves to enhance the fat- and protein-removing ability of the compositions of the present invention and interacts with the quaternary ammonium compound. This is not, however, an essential ingredient.
  • This component when included is intended to sequester metal ions and the most suitable sequestering agent will be in part determined by the other components of the composition.
  • Preferred sequestering agents are one or more of the following: citrates, formates, tartrates, gluconic acid, and 126- hexantriol thioglycolate .
  • EDTA is also acceptable but is far less effective than 126-hexantriol thioglycolate which is particularly preferred.
  • the citrates and/or formates which thus may be independently present or may be present in combination are preferably in the form of their alkali metal or ammonium salts.
  • Sodium or ammonium citrate is the preferred citrate and sodium formate is the preferred formate.
  • the sequestering agent is 126- hexantriol thioglycolate; and in the case of solid formulations the sequestering agent is preferably sodium citrate, sodium formate or a mixture thereof.
  • the oxygen donor when present, serves to loosen contaminants from the surface being cleaned and is particularly advantageously incorporated in liquid formulations.
  • the oxygen donor is an aluminium alkoxide, with aluminium triethoxide being the compound of choice.
  • the oxygen donor is preferably present in an amount of 0.1 to 2.0% and more preferably in the amount of 0.5 to 1.0%.
  • the oxygen donor has the effect of significantly improving the cleaning of non- metallic materials, and in particular plastics.
  • Other suitable oxygen donors include perborates but in general these require higher temperatures than the aluminium alkoxides .
  • Percarbonates , manganese salts, hydrogen peroxide or oxyhalides also represent suitable oxygen donors .
  • the polysaccharide when present, is present in an amount of 0.01 to 0.5% by weight, and more preferably in an amount of 0.1 to 0.5% by weight.
  • the polysaccharide is believed to provide a number of advantages to the compositions, the most important being its effect in improving the functions of the other components. It is believed that this enhancement may be due to the polysaccharide affecting the ionic properties of the composition with the result that the active ingredients are more evenly coated onto the surface to be treated. Consequently, substantially all soiling can be removed and prevented from re-depositing on clean surfaces.
  • Particularly preferred polysaccharides include D- glucosyl, D-manosyl, and D-glucisyluronic acid which has a primary structure of a cellulose backbone with trisaccharide side chains and pentasaccharide repeating units .
  • the balance of the composition is de-ionised water with the balance of the composition optionally including an oxygen donor to enhance the cleaning properties of the composition.
  • Alcohol, colours and fragrances may also be optionally included in the liquid formulations.
  • the alcohol may be monohydric or polyhydric, with isopropyl alcohol being preferable.
  • the preferred amount of alcohol, when present, is from 5.0 to 10.0%.
  • the balance of the composition is provided by a solid bulking agent which serves to absorb any water present in the non- ionic surfactant or other components thereby providing a dry composition.
  • the cationic surfactant or source of cations when present, is intended merely to moderate the activities of the other components and as such represents an optional component .
  • Powder formulations are obtained by incorporating the active components in the powder.
  • Sodium carbonate is a particularly preferred vehicle because it can be easily incorporated into a formulation, it provides an ideal base for incorporating the active chemicals and it also contributes towards water softening.
  • pH of the solution will remain above pH 9.
  • suitable powders include magnesium sulphate, potassium carbonate, sesquicarbonate, sodium bicarbonate and borax.
  • an oxygen donor, colours and fragrances may be included in the balance of the solid composition.
  • the essential part of the formulation consists of a surfactant, a metal silicate or meta-silicate as an emulsifier, a metal phosphate as a water softener, and a quaternary ammonium compound as a complexing agent.
  • the alcohol when present, has the effect of improving the appearance of the solution by improving its clarity.
  • silicates have wetting, emulsifying and soil suspending properties and the polyphosphates function by sequestering hard water salts.
  • Silicates and meta-silicates also have a good buffering action, which means that in the presence of acidic soils, an alkaline pH is maintained almost until they have been exhausted. Medical soils are, in general, acidic, and the buffering action of silicates is essential. Not all stainless steels are totally “stainless", and the presence of silicates, coupled with the presence of phosphates or polyphosphates will inhibit corrosion; this is especially important at points where a mild steel pin joins two stainless steel components. Silicates also inhibit aluminium alloy corrosion, especially when polyphosphates are present. There also appears to be some improved surface activity when phosphates or polyphosphates are used in conjunction with non-ionic surfactants.
  • a secondary function of the phosphates appears to be as a soil suspending agent which allows lifted soils to be rinsed away more easily. In many surgical cleaning formulations, lifted soils tend to redeposit, thus contributing to the residual soil levels after cleaning. The compositions of the present invention therefore do not suffer this disadvantage.
  • Citrates are soluble salts and the inclusion of an alkali-metal or ammonium citrate, together with an alkali -metal (preferably sodium) or ammonium formate in the formulation results in even greater soil lifting capability and those materials function as sequesting agents in the compositions of the present invention.
  • compositions of the present invention incorporate a sequestering agent which functions to enhance the removal of haemoglobin.
  • the sequestering activity of 126 hexantriol thioglycolate in particular was investigated and even at very low inclusion rates, very effective blood removal was achieved.
  • the preferred sequestering agent for iron removal is 126 hexantriol thioglycolate.
  • activity of this component appears to be enhanced considerably thus allowing very small inclusion rates in the compositions of the present invention.
  • aluminium tri-ethoxide gives the best results but other aluminium alkoxides are also effective.
  • Formulations containing aluminium triethoxide give excellent results when used to remove mucus and other soils from endoscopes and similar investigative instruments. Results both in soil removal and microbe control (which is a function of soil removal) where superior when compared with conventional aldehyde or other cleaning solutions.
  • the oxygen donor is thought to provide oxygen at the liquid/polymer surface where its activity enhances soil removal from most plastic materials and in particular from nylon 66 and polypropylene. Exceptional soil removal has been observed when cleaning endoscopes and similar instruments including oxygen masks where elevated temperatures cannot be used.
  • foam control agents which preferably are silicones. Colours and fragrances may also be included as required. The percentage of these components in the composition are determined by end use requirements .
  • a solid state formulation for cleaning surgical instruments was made by mixing the following solid state components:
  • aqueous solution of this formulation was prepared for use as a cleaning composition by dissolving lOg of the composition in one litre of water. This solution was then used for washing a variety of surgical instruments which were contaminated with known soils and micro organisms for the purpose of providing an indication of the efficacy of soil removal .
  • the aqueous composition of the invention showed superior soil removal results at a level not hitherto achievable by conventional cleaning agents. Cleaning also removed material which would otherwise protect micro organisms from subsequent exposure to disinfectants and sterilants.
  • Example 2 A concentrated liquid formulation for use in surgical instrument washing equipment was prepared from the following components:
  • a composition of this type is particularly suitable for instrument washing equipment of the type in which the cleaning a fluid and water are metered in. Typically, when used in diluted form, 1 part of this composition may be diluted with 10 to 100 parts water. Similar soil removal levels were obtained using this formulation as were obtained with the powder formulation of Example 1.
  • a concentrated liquid formulation was prepared from the following components:
  • Suitable applications are, for example, cases in which plastic materials need to be cleaned prior to autoclaving or disinfection.
  • Heat sensitive materials such as masks and tubing can also be thoroughly cleaned at lower temperatures using this composition without surface damage occurring, or without the absorption of chemicals which could be subsequently released under the reduced pressures encountered when administering gaseous surgical anaesthetics.
  • This composition is very effective at ambient or slightly raised temperatures i.e. lower than the temperatures usually encountered with larger surgical instrument washing machines .
  • the dilution rates for this liquid formulation will depend on the type of machines and degree of soiling encountered. In practical terms, dilution of between 10ml and 50ml of the liquid formulation per litre of wash water gives good results.
  • liquid formulations of the present invention may be used either in concentrated form or at dilutions up to 100 times.
  • Solid formulations may be diluted with water and are preferably diluted in the ' range of 5g to lOOg of solid composition per litre of water, and more preferably in the range 5g to lOg of solid composition per litre on the combined grounds of efficiency and economy.
  • compositions of the invention are highly effective when used for cleaning surgical instruments and medical equipment .
  • a solid composition is dissolved in water and applied to the surface to be treated.
  • a liquid composition may be applied neat to the surface or may be diluted with water prior to treatment of the surface.

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Detergent Compositions (AREA)

Abstract

La présente invention concerne une composition et une technique de nettoyage d'instruments ou analogues. En particulier, l'invention concerne des compositions destinées à éliminer tout fluide corporel présent sur les instruments chirurgicaux ou autres surfaces, telles que les tables d'opération et les plateaux pour instruments.
EP99947599A 1998-09-25 1999-09-23 Compositions de nettoyage pour instruments medicaux Expired - Lifetime EP1115824B1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9820863.0A GB9820863D0 (en) 1998-09-25 1998-09-25 Medical cleaning compositions
GB9820863 1998-09-25
GB9909724 1999-04-28
GBGB9909724.8A GB9909724D0 (en) 1998-09-25 1999-04-28 Medical cleaning compositions
PCT/GB1999/002969 WO2000018858A1 (fr) 1998-09-25 1999-09-23 Compositions de nettoyage pour instruments medicaux

Publications (2)

Publication Number Publication Date
EP1115824A1 true EP1115824A1 (fr) 2001-07-18
EP1115824B1 EP1115824B1 (fr) 2004-06-16

Family

ID=26314417

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99947599A Expired - Lifetime EP1115824B1 (fr) 1998-09-25 1999-09-23 Compositions de nettoyage pour instruments medicaux

Country Status (5)

Country Link
US (1) US6489276B1 (fr)
EP (1) EP1115824B1 (fr)
DE (1) DE69918142T2 (fr)
GB (1) GB9909724D0 (fr)
WO (1) WO2000018858A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001246423A1 (en) * 2000-03-09 2001-09-17 Martin, Alexander Bactericidal compositions comprising a quaternary ammonium salt
FR2825272B1 (fr) * 2001-05-31 2003-08-08 Oreal Composition cosmetique comprenant des particules de silicate dans un support de type emulsion huile-dans-eau
EP2261269B1 (fr) * 2003-07-09 2016-11-09 Arlanxeo Netherlands B.V. Procede de production d'un polymere comprenant des unites monomeres d'ethylene, une alpha-olefine et un norbornene de vinyle
GB0413950D0 (en) * 2004-06-22 2004-07-28 Ebiox Ltd Sanitizing method
US7354888B2 (en) * 2004-11-10 2008-04-08 Danisco A/S Antibacterial composition and methods thereof comprising a ternary builder mixture
US20070207073A1 (en) * 2006-03-03 2007-09-06 Drucker Tod H Apparatus for supporting and disinfecting a handheld instrument and/or a portion of the user's hand
US20100190676A1 (en) * 2008-07-22 2010-07-29 Ecolab Inc. Composition for enhanced removal of blood soils
US8540709B2 (en) 2009-12-07 2013-09-24 Covidien Lp Removable ink for surgical instrument
US9365805B2 (en) * 2014-05-15 2016-06-14 Ecolab Usa Inc. Bio-based pot and pan pre-soak
JP2018525535A (ja) * 2015-08-19 2018-09-06 ベラテルム アーゲーＢｅｒａｔｈｅｒｍ Ａｇ 媒体と接触したステンレス鋼表面上のルージュ沈着物を除去するための水性洗浄液、その使用及びそれを調製するためのプロセス
ITUB20156321A1 (it) * 2015-12-04 2017-06-04 Maurizio Priori Metodo per sanificare un dispositivo medico, in particolare per il trattamento localizzato della cute
WO2020069124A1 (fr) 2018-09-28 2020-04-02 Siemens Healthcare Diagnostics Inc. Réactif de lavage contenant de l'alcool gras alcoxylé et ses procédés de production et d'utilisation

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Publication number Priority date Publication date Assignee Title
GB676895A (en) * 1949-11-14 1952-08-06 Alistair Frederick Mckenzie Ja Improvements in disinfectant and detergent compositions
USH269H (en) * 1985-03-11 1987-05-05 A. E. Staley Manufacturing Company Disinfectant and/or sanitizing cleaner compositions
US5464484A (en) * 1994-06-07 1995-11-07 Betz Laboratories, Inc. Oil splitting aluminum cleaner and method
US5663132A (en) * 1995-03-01 1997-09-02 Charvid Limited Liability Company Non-caustic composition comprising peroxygen compound and metasilicate and cleaning methods for using same

Non-Patent Citations (1)

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Title
See references of WO0018858A1 *

Also Published As

Publication number Publication date
DE69918142T2 (de) 2005-07-28
EP1115824B1 (fr) 2004-06-16
DE69918142D1 (de) 2004-07-22
WO2000018858A1 (fr) 2000-04-06
US6489276B1 (en) 2002-12-03
GB9909724D0 (en) 1999-06-23

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