EP1051123A1 - Optisches objektverfolgungsystem - Google Patents

Optisches objektverfolgungsystem

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Publication number
EP1051123A1
EP1051123A1 EP99904343A EP99904343A EP1051123A1 EP 1051123 A1 EP1051123 A1 EP 1051123A1 EP 99904343 A EP99904343 A EP 99904343A EP 99904343 A EP99904343 A EP 99904343A EP 1051123 A1 EP1051123 A1 EP 1051123A1
Authority
EP
European Patent Office
Prior art keywords
camera
data
optically detectable
instmment
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99904343A
Other languages
English (en)
French (fr)
Inventor
Eric Richard Cosman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Covidien AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to EP20040001661 priority Critical patent/EP1415609A1/de
Publication of EP1051123A1 publication Critical patent/EP1051123A1/de
Withdrawn legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36Image-producing devices or illumination devices not otherwise provided for
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/20Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/10Computer-aided planning, simulation or modelling of surgical operations
    • A61B2034/107Visualisation of planned trajectories or target regions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/20Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
    • A61B2034/2046Tracking techniques
    • A61B2034/2065Tracking using image or pattern recognition
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/20Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
    • A61B2034/2072Reference field transducer attached to an instrument or patient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36Image-producing devices or illumination devices not otherwise provided for
    • A61B2090/363Use of fiducial points
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36Image-producing devices or illumination devices not otherwise provided for
    • A61B2090/364Correlation of different images or relation of image positions in respect to the body
    • A61B2090/365Correlation of different images or relation of image positions in respect to the body augmented reality, i.e. correlating a live optical image with another image
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37Surgical systems with images on a monitor during operation
    • A61B2090/371Surgical systems with images on a monitor during operation with simultaneous use of two cameras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37Surgical systems with images on a monitor during operation
    • A61B2090/378Surgical systems with images on a monitor during operation using ultrasound
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3937Visible markers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3937Visible markers
    • A61B2090/3945Active visible markers, e.g. light emitting diodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/397Markers, e.g. radio-opaque or breast lesions markers electromagnetic other than visible, e.g. microwave
    • A61B2090/3975Markers, e.g. radio-opaque or breast lesions markers electromagnetic other than visible, e.g. microwave active
    • A61B2090/3979Markers, e.g. radio-opaque or breast lesions markers electromagnetic other than visible, e.g. microwave active infrared
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3983Reference marker arrangements for use with image guided surgery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/50Supports for surgical instruments, e.g. articulated arms
    • A61B2090/502Headgear, e.g. helmet, spectacles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/10Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis

Definitions

  • the invention relates generally to medical equipment used in the surgical treatment of disease, and more particularly to a system and method for medical instrument navigation by optically tracking the positions of instruments used during surgery or other treatments in relation to a patient's anatomy.
  • Image guided stereotaxy is widely used in the field of neurosurgery. It involves the quantitative determination of anatomical positions based on scan data taken from a CT, MRI or other scanning procedures to obtain three-dimensional scan data. Typically, the image scan data is placed in a computer to provide a three-dimensional database that may be variously used to provide graphic information. Essentially, such information is useful in surgical procedures and enables viewing a patient's anatomy in a graphics display.
  • image guided stereotactic head frames is commonplace. For example, see U.S. Patent No. 4,608,977 issued September 2, 1986 and entitled, System Using Computed Tomography as for Selective Body Treatment.
  • Such structures employ a head fixation device typically with some form of indexing to acquire referenced data representative of scan slices through the head.
  • the scan data so acquired is quantified relative to the head frame to identify individual slices.
  • a probe or surgical instrument may then be directed to an anatomical feature in the head by mechanical connection to the head frame based on scan data representations.
  • Three-dimensional scan data has been employed to relate positions in a patient's anatomy to other structures so as to provide a composite graphics display.
  • a mechanically linked space pointer (analogous to a pencil) attached to the end of an encoded mechanical linkage might be directed at a patient's anatomy and its position quantified relative to the stereotactic scan data.
  • the space pointer might be oriented to point at an anatomical target and so displayed using computer graphics techniques.
  • Such apparatus has been proposed, using an articulated space pointer with a mechanical linkage. In that regard, see an article entitled "An Articulated Neurosurgical Navigational System Using MRI and CT Images,"
  • the head frame and the articulated space pointer are mechanically connected to an apparatus used to measure and calculate the position of the probe or pointer. Consequently, although a relatively high number of degrees of freedom can be provided to the pointer (or other tool coupled to the pointer), the mechanical linkage may still restrict the possible ranges of motion available to the clinician. Furthermore, the linkages may be large and obtrusive, and can be difficult to sterilize.
  • the apparatus tracks the position of the space pointer in relation to the patient's anatomy, the clinician is still free to move about the patient and operate from any desired position. This is not reflected by the data produced by the device.
  • any graphical representation of the surgical field may be disorienting, confusing, or not representative of the "surgeon's eye” view.
  • the need for relating external treatment apparatus or surgical viewing directions to a specific target arises in several aspects.
  • the need arises in relation to the treatment of internal anatomical targets, specifically to position and maintain such targets with respect to a surgical instrument such as a probe, a microscope with a specific direction and orientation of view, or an X-ray treatment beam associated with a large external apparatus.
  • a need exists for methods for aligning a surgical instrument, probe, or beam not attached by any mechanical linkage, to impact specific anatomical targets via a path selected to avoid injury to other critical anatomical structures.
  • an optical camera apparatus functions in cooperation with a computer system and a specially configured surgical instrument.
  • the camera system is positioned to detect a clinical field of view and to detect index markers on a surgical instrument, a patient, and/or a surgeon.
  • the markers are tracked by the camera apparatus.
  • the image scan data (such as from a CT or MR scan of the patient's anatomy) and data specifying the position of the instrument and the surgeon are transformed relative to the patient's anatomy and the camera coordinate system, thereby aligning the scan data, patient position and orientation data, instrument position and orientation data, and surgeon position and orientation data for selectable simultaneous viewing on a computer display.
  • Various exemplary embodiments are given of the use of lines, arrays of points, geometric patterns and figures, lines of light, and other optically detectable marker configurations to identify the position and orientation of a surgical instrument, a patient, and a surgeon.
  • the disclosed embodiments have the advantage of being wireless and optically coupled to the camera tracking system. Moreover, they can be relatively economical and lightweight in comparison to the mechanically coupled tracking devices described in the background section above.
  • FIGURE 1 schematically illustrates a system for optically tracking instruments and other objects in a surgical field in accordance with the present invention
  • FIGURE 2 which includes FIGURES 2A, 2B, 2C, 2D, 2E, 2F, 2G, and 2H, illustrates various configurations of optically detectable geometric objects and patterns associated with objects to be tracked in accordance with the system of FIGURE 1;
  • FIGURE 3 which includes FIGURES 3 A, 3B, 3C, 3D, 3E, and 3F, illustrates various optically detectable objects attached to instruments in accordance with the present invention
  • FIGURE 4 which includes FIGURES 4A, 4B, and 4C, illustrates additional alternative embodiments of optically detectable objects in accordance with the present invention
  • FIGURE 5 schematically shows several combinations of graphics, video, and reconstructed representations derived from optically tracking of a surgical field
  • FIGURE 6 schematically shows a battery-powered optically tracked instrument 5 for use in accordance with the present invention
  • FIGURE 7 illustrates the functions performed in the combined processing of tracking, videos, and/or image data in a display in accordance with the present invention
  • FIGURE 8 is a flowchart showing the sequence of steps performed in tracking an optically detectable object.
  • FIGURE 9 is a flowchart illustrating the sequence of steps performed in generating a display when a surgical instrument, a patient, and a surgeon are all tracked by a system in accordance with the invention.
  • an embodiment of a system according to the invention is shown schematically as including a camera system 10 that has a field of view that includes multiple elements.
  • the elements can include a surgical field for surgical application or a treatment field for therapy applications.
  • Part of the patient's body 22 may or may not be in the camera field.
  • Mounted to the patient within the camera field are several optically detectable objects such as markers 24, 26, and 28, which are mounted directly on the patient, or alternatively, identifiers 30, 32, 34, and 36 connected to a structure 38 that is rigidly connected to the patient's body 22.
  • the markers 24, 26, and 28 or the identifiers 30, 32, 34, and 36 may be light-emitting, light-reflecting, or otherwise optically differentially detectable geometric structures, patterns, or elements. They may comprise, for example, light-emitting diodes ("LEDs") capable of emitting infrared, visible, or other wavelengths of light; reflectors, such as mirrors, reflective paint, reflective sheeting or tape, reflective dispersions, and so on.
  • the markers or identifiers may be fabricated in any of various shapes including discs, annular plates or rings, domes, hemispheres, spheres, triangles, squares, cubes, diamonds, or combinations thereof. It has been found that circular stick-down circles, domes or spheres are usable in this application.
  • the identifier 36 may include a reflective surface of triangular shape, for example, that is detectable in spatial position and orientation by the camera system 10. In this way, the patient's position and orientation can be detected with respect to the coordinate system of the camera system 10; this procedure will be discussed in further detail below.
  • the camera system 10 comprises one or more cameras, each of which can be selected from optical cameras of various known types. In FIGURE 1, three cameras are shown as part of the camera system 10.
  • a right-mounted camera 12 and a left- mounted camera 16 are capable of resolving two-dimensional images.
  • the dashed lines 40 illustrate the field of view of the right-mounted camera 12; the left-mounted camera 16 has a similar (but displaced) field of view.
  • the cameras provide optical camera data to processor 42 related to optically detectable objects in the common field-of-view of the cameras included in the camera system 10.
  • processor 42 stereoscopic or three-dimensional position data on the optically detectable object positions in the coordinate camera system can be derived by the processor 42.
  • the positions and orientations of objects within the camera system field of view can be determined rapidly by the processor 42 and sent to a computer 44.
  • the computer 44 has software to represent the positions and orientations of those objects in camera coordinates and display the objects in various representations on a display means 46 as desired by the clinician.
  • a lateral support 18 for the cameras 12 and 16 is fixed by a coupler 20 to a rigid reference R, such as the ceiling, wall, or floor of a room.
  • a rigid reference R such as the ceiling, wall, or floor of a room.
  • light sources 50 and 52 which in the disclosed embodiment are mounted in proximity to cameras 12 and 16, respectively. These light sources can send light outward as for example along a path represented by a dashed line 54 to be reflected off of a reflective optically detectable object such the marker 24 on the patient's body 22. Reflected light then returns along a path such as that represented by a dashed line 56, and is detected by the camera 12.
  • the marker 24 and other markers and identifiers in the field include reflective surfaces, points, lines, or regions
  • these structures can be represented as camera data in a three-dimensional coordinate system fixed with respect to the camera system 10.
  • the light sources 50 and 52 are be pulsed clusters of LEDs in the infrared (IR) frequency range, and cameras 12 and 16 have selective IR filters matched to the IR source wave length.
  • IR infrared
  • ambient lighting conditions can be used to enable cameras 12 and 16 to detect the markers and identifiers.
  • the marker 24 for example, is a brightly colored (white, green, red, etc.) disc, sphere, or other shape that stands out in contrast to whatever is visible in the background, then the marker's position can be detected by the cameras.
  • the identifier 30 is bright white, and the surface of head clamp structure 38 is dark or black, then the identifier 30 can be discriminated by the camera system 10.
  • one or more cameras may be used in the camera system 10. As is well known in the art, two or more cameras will yield stereoscopic data on objects in the clinical field of view in relation to the camera frame of reference or in camera coordinates.
  • the optically detectable identifiers may comprise light sources themselves.
  • the identifiers may be LEDs or other powered light sources such as lamps, possibly enclosed in diffusing globes.
  • the light elements of identifiers 30, 32, and 34 can be triggered by and synchronized with cameras 12 and 16.
  • electronic shutters in the cameras can be used to enable the camera detectors at just the time when elements 30, 32, and 34 illuminate, thereby increasing the signal-to-noise ratio.
  • a surgical instrument 60 can be of any known surgical type, including but not limited to probes, cutting devices, suction tubes, endoscopes, electronic probes, and other tools.
  • Attached to the instrument 60 is at least one optically detectable element 62, which can comprise various geometric structures that are detectable and recognizable by cameras 12 and 16.
  • a rod indicator 64 is shown in a fixed relationship with a spherical indicator 66.
  • these indicators 64 and 66 can comprise reflective material, bright or colored surfaces, or light-emitting elements which are detected by cameras 12 and 16.
  • the three-dimensional position and orientation of the element 62 can then be calculated using the camera data processor 42 and the computer 44.
  • the orientation and position of the instrument 60 can thereby be determined.
  • a calibration or pre-fixed position of the element 62 with respect to the instrument 60 may be performed before surgery or intraoperatively (see, 8 for example, several of the products of Radionics, Burlington, Massachusetts).
  • indicators 62 and 66 are light emitting, they can be connected to the processor 42 (dashed line), and synchronized to strobing of the camera system 10.
  • light-detectable indicators 70, 72, and 74 are shown on a surgeon 76.
  • the indicators 70, 72, and 74 are attached to a headband 78 worn by the surgeon 76.
  • This optical detectable array can then be tracked by the camera system 10 along with the patient's body 22 and the instrument 60.
  • the camera data processed in the processor 42 and assimilated in the computer 44 can thereby track in three-dimensional space relative to the camera system 10 the positions of all elements and their relative orientations.
  • the processor 42 can be connected to the surgeon's headband 78 (dashed line) to synchronize the indicators' signals.
  • image data can be provided to the surgeon 76 via an optical headset 80 worn by the surgeon.
  • the optical headset 80 is a binocular magnifier with built-in image-splitting elements.
  • Graphic data from the processor 42 originating from image scan data 48 pre-scanned from the patient, can be sent into the viewing elements of the headset 80 to update the surgeon 76 with location data correlated to the surgeon's viewing position.
  • a reconstructed image of CT or MRI data taken previously and provided to the computer 44 can be displayed via the headset 80, thereby permitting the surgeon to see a "reconstructed" view from the direction of his physical perspective.
  • the computer 44 can assimilate historic image data 48 and convert it to reconstructed planar images and send that information to a display element 46, which thereafter can be "piped" or transmitted to the headset 80 for the surgeon's use.
  • the headset 80 can comprise at least one video camera 82 capable of viewing the surgical field from the surgeon's direction. Information from the video camera 82 can be sent (via the dashed line) to the processor 42 and the computer 44 and onto the display 46. Once again, that information can then be reconstructed and displayed via a split screen prism in the surgeon's field-of-view via his headset 80.
  • the surgeon's view information can be oriented in a suitable direction by the tracking of the indicators 70, 72, and 74 with the camera system 10, as discussed above.
  • the video information displayed in the headset 80 can be 9 rendered from stereotactic camera coordinates.
  • the processor 42 in one embodiment of the invention, is a dedicated processor for electronic data from the camera system 10.
  • the processor 42 is also capable of synchronously controlling the light emitters 50 and 52, if needed to illuminate the optically detectable markers or indicators on the patient 22, the head holder structure 38, the instrument 60, or the surgeon
  • Image data 48 can be in memory of the computer 44 or otherwise transferred to computer 44, as for example optical disk, magnetic tape, etc.
  • the visualization of camera data and image scan data is accomplished via the display 46, which in various embodiments can be a CRT, liquid crystal display, heads-up display, or other display device.
  • the visual image presented by the display 46 represents the position of the instrument 60 in terms of orientation, tip position, and other characteristics with respect to the image scan data 48 in a variety of ways. For examples, see documentation for the OTS product of Radionics, Burlington, Massachusetts. Specifically, cataloging slices, probe view, in-probe reconstructions, three-dimensional wedge views, and other views of the instrument 60 relative to the patient 22 can be represented on the display 46. Also, the surgeon's view, via registration of the visual headset 80 (by identifying the indicators 70, 72, and 74 as described above) can also be shown on the display 46.
  • an instrument 60 for use with the present invention can be nearly any surgical instrument or device, such as a microscope, an endoscope, a cutting instrument, an ultrasonic imaging probe, or a treatment device such as an X-ray collimation device for a linear accelerator (LINAC).
  • LINAC linear accelerator
  • the objects in this field of view of the camera system 10 can be tracked in the three- dimensional coordinate space of the camera system 10.
  • the instrument 60 can be calibrated relative to the patient 22 in a variety of ways (see the OTS Tracking System of Radionics, Burlington, Massachusetts for examples).
  • the instrument 60 is touched to a plurality of fiducial markers placed on the patient 22 (for example, the markers 24, 26, and 28), natural landmarks on the patient's skin, surface swabbing of the patient's anatomy, a reference to real-time imaging data (for 10 example ultrasound, MRI, CT, etc.) in the situation where the structure 38 is connected or associated with such an imaging apparatus, and so on.
  • a fiducial markers placed on the patient 22 (for example, the markers 24, 26, and 28), natural landmarks on the patient's skin, surface swabbing of the patient's anatomy, a reference to real-time imaging data (for 10 example ultrasound, MRI, CT, etc.) in the situation where the structure 38 is connected or associated with such an imaging apparatus, and so on.
  • the processor 42 uses such data in a calibration step so that the position of the instrument 60 is in a known position and orientation relative to the patient 22 or the structure 38 affixed to the patient 22, or even with respect to apparatus elsewhere in the room such as a linear accelerator, an image scanner, or an apparatus on a surgeon (the headband 78, for example).
  • FIGURE 2 various embodiments of patterns, shapes, and objects for the optically detectable elements that can be used on, for example, the instrument 60 (FIGURE 1) or the patient 22, the surgeon 76, a microscope, or other surgical device not shown.
  • the surgical instrument 60 is rendered schematically.
  • the instrument 60 is depicted in the embodiment set forth in FIGURE 2, it should be noted that similar or identical configurations can be used on the patient 22, the structure 38, the surgeon 76, or any other implement to be tracked.
  • the instrument 60 has a surgical axis (dashed line 84) and a focal point, end point, isocenter, or other characteristic point 86. It can have other independent axes such as those illustrated by dashed lines 85 and
  • a geometric object 88 is attached to the instrument 60 by a connector 90.
  • the connector 90 is a rigid coupling and is in a predetermined relationship with the instrument 60; alternatively, it could be in an arbitrary relationship with the instrument 60 and subject to calibration.
  • the geometric object 88 bears a bright portion 92 (the hatched area) on its surface.
  • the bright portion 92 of the surface of the geometric object 88 may comprise reflective paint, reflective film, a brightly colored surface in a particular color spectrum, or an illuminated field.
  • the camera system 10 is represented here only schematically, but could comprise the elements described in FIGURE 1, including cameras, light sources, a processor, a computers, image data, and a display, among other items. Further, it should be noted that although the geometric object 88 and its bright portion 92 are specifically described and shown as triangular in configuration, many other shapes are possible and equally operative in the context of the invention, which is not so limited.
  • the position and orientation of the instrument 60 can be determined by tracking the position and orientation of the geometric object 88.
  • the instrument 60 may be a rigid body of complex shape. Its position, for example, may be characterized by axes 11 such as 84, 85, and 87, and its orientation around an axis 84 may be characterized by a rotation angle indicated by an arrow 83.
  • this rotation angle 83 and the position and orientation of the axes 84, 85, and 87 may be tracked relative to the coordinate system of the camera system 10. This can be done by rigid body transformations which are well known to those skilled in matrix mathematics.
  • the instrument 60 is an endoscope or a microscope for which the axis 84 represents a viewing direction
  • the characteristic point 86 is a point desired to be viewed in the surgical field
  • angle and if the axes 85 and 87 represent the orientation of the viewing field relative to the patient's coordinate system or the coordinate system of image scan data, then tracking the geometric object 88 will provide position and orientation tracking of the endoscopic or microscopic field of view.
  • Detecting the edges of the bright portion 92 in the three-dimensional coordinate system relative to the camera system 10 enables the direction and orientation of the geometric object 88 to be determined.
  • tracking of the instrument 60 can be accomplished (see for example the OTS Optical Tracking System of Radionics, Burlington, Massachusetts).
  • the camera system 10, the processor 42, and the computer 44 are adapted to detect edges such as a line 94 between the bright portion 92 and the remainder of the geometric object 88, as well as the other respective edges of the triangle or geometric shape. This may be accomplished by differential detection of the shaded area of the triangle versus the perimeter band, which may not be of reflective, brightly colored, or illuminating optically detectable material. Edge detection of geometric shapes can be done by well-known segmentation or detection algorithms in the processor 42 or the computer 44. Three non- collinear points define a plane; additional data can be used to define position and orientation within the plane.
  • the index structure comprises a four-sided geometric shape 96 having a shaded band 98 which may be of reflective or bright material. Inside is a relatively dark area 100 which may be of non-reflective material. Alternatively, the roles of the shaded band 98 and dark area 100 could be reversed.
  • the camera system 10 detects this object and the linear edges of the band 98 or 12 the dark area 100. This establishes the position and orientation of the shape 96.
  • the shape 96 is attached by a connector 102 to the instrument 60.
  • Such a shape 96 could be easily made.
  • the differentially reflective areas i.e., the shaded band 98 and the dark area 100
  • any of these procedures would be inexpensive and lead to very sharp linear borders between the two regions. These borders can then be detected by the camera system 10 via linear discrimination algorithms in the processor 42 and the computer 44 (FIGURE 1).
  • the shape 96 is a parallelogram or a square, the orientation of the plane of the shape 96 can easily be determined by vector cross-product calculations of the linear positions of the borders in three-dimensional space with the edges of the object.
  • the connector 102 is optional; if the shape 96 is integrally part of the tool or instrument 60, viz. part of its handle, then an explicit connector 102 would not be needed.
  • the instrument 60 has attached to it an optically detectable shape 104 in the form of a solid or a plate.
  • an optically detectable shape 104 in the form of a solid or a plate.
  • the patterns 110 may be, for example, reflective patches or painted areas on a black background. These structures by their respective shapes and orientation encode the position and orientation of the shape 104.
  • the patterns can be circles, domes, spheres, or ellipsoids which are detectable by the camera system 10.
  • the shape 104 may be flat or curved, according to needs.
  • one of the patterns, e.g. pattern 110 has a more linear structure which is distinguishable from curvilinear shapes such as shapes 106 and 108 also identifiable by the camera system 10.
  • the pattern 108 has an annular shape with a hole 112 in the middle to distinguish it from a dot-shaped pattern 106.
  • the combination can uniquely identify and locate the shape 104, and therefore the instrument 60, in its orientation and position.
  • the various patterns 106, 108, and 110 can be distinguished from each other, from the background, and from other types of surgical instruments by their reflectivity, color, position, and geometry to give a unique signature or knapping to the instrument 60.
  • the tool could be a special forceps, and the shape 104 with its distinguishing optical characteristics, could be known to the camera system 10 and its associated computer system 44 to be a particular type of forceps.
  • other specific tools can have different optically detectable signature structures. 13
  • a flat detectable shape 114 is shown.
  • the shape 114 has orthogonal bar patterns 116 and 118, which could be again reflective tape on a black background of the shape 114. These patterns are recognizable and distinguishable by detecting the borders, such as a line 120 between the patterns 116 and 118 and the background. Linear structures are easily detectable by camera systems and pattern recognition software.
  • the camera system 10 could easily scan such a geometric linear pattern in distinguishing the linear bar patterns, thereby determining the orientation of the patterns 116 and 118 as orthogonal and in a given spatial three-dimensional position.
  • the orientation of the shape 114 and its position in space can be determined in the coordinates of the camera system 10.
  • a fixed relationship between the instrument 60 and the shape 114 via a connector 122 can then be used to identify the position and orientation of the instrument 60 in all of its movements within the field of view of the camera system 10.
  • FIGURE 2E shows yet another embodiment of the present invention with shows a linear rod 124 and a spherical object 126 coupled together.
  • a reflective surface For instance, a reflective surface
  • the spherical object 126 on the rod 124 could be taped or painted onto the rod 124.
  • the spherical object 126 bearing reflective tape or paint is, in the disclosed embodiment, coaxial with the painted surface 128 of the rod 124.
  • the camera system 10 is capable of recognizing the linear form of the rod 124 and the center of the spherical object 126. Accordingly, a detection algorithm in the computer 44 (FIGURE 1) could determine the linear configuration and central axis of the rod 124, and the centroid point of the spherical object 126, thereby determining a vector direction along the axis of the rod 124 and a uniquely identified endpoint at the spherical object 126.
  • the rod 124 and the spherical object 126 are joined by a connector 129 to the instrument 60, thereby specifying the position and orientation of the instrument 60 with respect to the camera system 10.
  • another example of the present invention comprises a longitudinal rod 130 with a reflective linear surface 132 (shaded) and an orthogonal rod 134 with two reflective segments 136 and 138 (shaded).
  • These linear structures again are detectable by the camera system 10, thereby determining the orientation of the plane defined by the longitudinal rod 130 and the orthogonal rod 134. As described above, this is information is then used to determine the orientation and movement of the instrument 60, 14 which is coupled to the rods 132 and 134 via a connector 139, in three-dimensional space.
  • FIGURE 2G shows yet another example of rod-like structures in a triangle 140.
  • the shaded linear segments 142, 144, and 146 lie at the edges of the triangle 140 and define the plane and orientation of the triangle 140.
  • the triangle 140 is attached to the instrument 60 by a connector 148, and the instrument is tracked as described above.
  • V-shaped structure 150 comprising identifiable leg segments 152 and 154 (shaded) provides a similar position and orientation vector analogous to the previous examples.
  • FIGURE 3 presents several further embodiments of the present invention that are useful in certain applications.
  • a plate 160 or similar structure has detectable areas 162, 164, and 166 (shaded).
  • a connector 168 couples the plate 160 to the instrument 60.
  • the plate 160 with its identifiable multiple areas, is a disposable sterile-packed device which can be detachably coupled to the connector 168.
  • the detectable areas 162, 164, and 166 can be, for example, reflective disks that are adhesively affixed to the plate 160 in particular positions that are recognizable and indexed by the camera system 10 in conjunction with the processor 42 and the computer 44 (FIGURE 1).
  • the concept of a disposable, single use, sterile-packed, optically detected index marker such as that shown in FIGURE 3 A has several advantages over non-disposable, more expensive devices.
  • the plate 160 can be coupled to the connector 168 in a pre-calibrated or a non-precalibrated orientation. If calibrated, it will have a known relationship to the instrument 60 and any focal points, features, or directions thereof. If non-precalibrated, the plate 160 could simply be "stuck" onto the connector 168 and used in an intraoperative calibration procedure to determine translations, rotations, and other transformations of the plate 160 and instrument 60 prior to defining the movement and relative orientation of the instrument 60. The process of intraoperatively calibrating positions, directions, and orientations of the instrument 60 is facilitated by an intraoperative calibration holder (not shown; see the products of Radionics, Burlington, Massachusetts).
  • a plate 170 is attached to the instrument 60 by a connector 172.
  • dome-shaped structures 174 and 176 are located on the surface of the plate 170.
  • the dome-shaped structures 174 and 176 comprise embedded illumination devices (e.g., LEDs).
  • the dome-shaped structures can include surface-mounted illumination devices, or can simply be made from reflective material.
  • the dome-shaped structures 174 and 176 are then detectable by the camera system 10, as described above. If the dome-shaped structures have spherical or convex surfaces, then the camera system 10 can detect their surfaces and average the three-dimensional positions of the surface points to identify a centroid which may, for example, be the center of a sphere or a hemisphere. Accordingly, there can be several of these spherical or dome-shaped structures on the plate 170 in a pattern or array.
  • the structures can be in a linear array, on the comers of a triangle, on the comers of a square, or in a multiple indexed array to provide position, orientation, and transformation information to a system according to the invention.
  • a plate 180 is attached to the instrument 60 in a similar fashion to that described above.
  • reflective patterns 182 and 184 are identifiable by the camera system 10 and its analysis system to discriminate them from other objects in the field, just as is done in all the previous examples.
  • the patterns 182 and 184 are square or diamond-shaped patches of reflective paint or tape; alternatively, they could be brightly colored surfaces with different colors to be detected by the camera system 10. Multiple arrays or groups of such diamond-shaped patterns with differential reflective and non-reflective areas are possible to facilitate discrimination by the camera system 10.
  • a background surface 186 on the plate 180 may be of opaque, black character so that the linear edges between the patterns 182 and 184 and that surface 186, for example, have a sharp optical delineation. This makes it simpler for the camera system 10 and its processor 42, and computer 44 to detect such an edge. If the edge is straight, then detection along the lined contour can readily be performed by well-known analysis methods. This can give precise linear directions which in turn can define the vector and positional orientation of the entire plate 180, and thus the orientation of the instrument 60, with high accuracy.
  • a plate 190 is shown in a somewhat triangular or trapezoidal shape. It has on it linear structures 191 and 192, which may be reflective edges or other patterns laid down or fastened to the surface 16 plate 190.
  • the linear structures 191 and 192 provide contrast for optical discrimination by being highly reflective or very brightly colored surfaces that are detectable by and analyzable by the camera system 10, as described above.
  • the linear borders on both sides of the structures 191 and 192 make possible linear discrimination analysis of these surfaces and also, by mutual information theory, an easily recognizable pattem.
  • the pattem is a non-parallel linear or V-shaped pattem of the elements 191 and 192.
  • Such a V-shaped pattem corresponds to and defines two vectors, which in turn can define the plane and orientation of the plate 190, and thus the instrument 60.
  • the instrument 60 is provided with three spherical elements 193, 194, and 195 in a linear configuration, each of which is made to be reflective or light-emitting.
  • the instrument 60 bears three spherical elements 196, 197, and 198 in a triangular configuration, each of which is reflective, light-emitting, or otherwise optically detectable.
  • the centroids define a plane that specifies the orientation of the instrument 60.
  • FIGURE 4A a solid three-dimensional optically detectable structure is attached to the instrument 60 or comprises part of the instrument 60 itself.
  • the structure includes a rod 200 which is attached by coupler 202 to a sphere 204.
  • the rod 200 and the sphere 204 comprise reflective or distinctly colored material detectable by the camera system 10.
  • the reflective rod 200 has the advantage that from all directions it has a similar linear shape, the edges of which are discriminated by the camera system 10 and detected by linear edge detection.
  • a centroid axis 206 can therefore be calculated for the rod 200 by the processor 42 and the computer 44 (FIGURE 1).
  • the reflective sphere 204 defines a centroid 208 which can be detected by spherical edge detection of the sphere 204 and appropriate centroid calculation in the processor 42 and the computer 44.
  • the combination of the axis 206 and the centroid 208 determines the plane defined by the sphere 204 and the rod 200, and thus the orientation and position of the instrument 60.
  • a solid prism-shaped object 210 is coupled by a connector 212 to the instrument 60.
  • a solid prismoidal stmcture 222 has distinguishing optically detectable markings which perform as a signature of the instmment 60 to which it is attached. On one face of the stmcture 222, there is shaded area 224 having a distinct shape. On another face, there are two separate shaded areas 226 and 228 having distinguishable size and shape characteristics.
  • the camera system 10 can determine by the size and shape characteristics of the shaded areas 224, 226, and 228 the orientation and position of the stmcture 222, and thus the orientation and position of the instnce 60. As described above, a large number of different and identifiable objects such as the stmcture 222 can be used to distinguish one tool from another. The detectable faces on different sides of the stmcture 222 will ensure that the stmcture 222 is identifiable from nearly any direction of view by the camera system 10.
  • Patterns such as bar codes or distinguishable line or object orientations can be used to encode the stmcture 222 (and thereby the instmment 60), allowing each different type of instmment to be recognizable via pattem recognition algorithms implemented in the processor 42 and the computer 44.
  • FIGURES 2, 3, and 4 While most of the embodiments described above (in FIGURES 2, 3, and 4) include a connector to couple an optically detectable stmcture to the surgical instmment 60, it should be noted that the objects, shapes, and patterns in the above examples can generally be built integrally into the instmment 60 itself. The very shape of the instmment may be optically detectable and classified and tracked by the camera system 10 and other processing elements, as described above.
  • the embodiments of FIGURES 1, 2, 3, and 4 have the advantage of providing optically coupled, non-mechanically coupled, wireless tracking.
  • the marker objects of FIGURES 2, 3, and 4 can be made simply, economically, lightweight, and sterilizable or sterilely packaged. Each embodiment has practical advantages relative to the frame-based or mechanically-linked space pointers given as examples in the background section above.
  • FIGURE 5 illustrates the operative functionality of a system according to FIGURE 1.
  • the surgical instmment 60 has an optically detectable index stmcture 230.
  • a dynamic 18 referencing head clamp 232 with index marks 234, 236, and 238 is present; the clamp 232 further includes an additional index marker 240.
  • a processor 242 and a computer 244 convert camera data from the camera system 10 for an image display 246, which shows a representation of the position of the instmment 60 as a dashed line 248 relative to an anatomical stmcture 250.
  • a predetermined point on the instmment 60 such as a tip or a focal point, is indicated relative to the anatomical stmcture 250 as a point 252. Examples of such coordinated display of probe orientation and image data is given in the product of OTS by Radionics, Burlington, Massachusetts.
  • the processor 242 and the computer 244 are also capable of generating a separate representation 254 of the position of the instmment 60.
  • the separate representation 254 displays in a two- or three-dimensional form 256 the position of the instmment 60 in comparison to an anatomical rendering 258, along with other optional representations of probe, anatomy, or target points such as a target point 260.
  • the separate representation 254 is reconstmcted from two-dimensional or three-dimensional image data such as CT or MR scans taken of the patient previously or contemporaneously in a real-time image scanner during surgery or treatment.
  • three-dimensional analysis of the position of the instmment 60 can be accomplished by determined by the stereoscopic cameras 12 and 16, together with the processor 42 and the computer 44. This can be done based on LED or reflective infrared light processing, or alternatively based on direct visible-light video processing of information from the two cameras 12 and 16. It can be advantageous to provide the cameras 12 and 16 with infrared optical filters. If the optically detectable objects used in the system are infrared LEDs or if the cameras have pulsed infrared light sources near them, then filtering will increase the signal-to-noise ratio of the tracking signal and reduce the effect of any ambient light background.
  • a third camera 14 is provided (see also FIGURE 1).
  • the third camera 14 is preferably a standard video camera which views the surgical field.
  • the processor 42 and the computer 44 further display the view from the third video camera 14 in an additional display 262. In this way, a direct video view of the patient 264 is available.
  • a view of the instmment 60 (seen as an instlement image 266 with an index marker image 268) is seen from actual video. 19
  • a virtual extrapolation of the probe shown as a dashed line 270 with a tip or target point 272, can be determined from the analysis shown on the alternative representation 254.
  • this virtual extrapolation is overlaid directly onto the additional display 262 so that direct comparison of the reconstmcted three-dimensional navigation image of the alternative representation 254 can be compared to an actual video image on the additional display 262.
  • Correspondence and registration between a reconstmcted image and an actual image in this way confirms the correctness of the probe orientation, and consequently the virtual position of unseen elements such as probe tip and probe position, for example in the depths of the surgical wound.
  • a hybrid of reconstmcted stereoscopic tracking by one set of cameras e.g., the cameras 12 and 16
  • can be displayed and coordinated with respect to video imaging from another set of cameras e.g., the video camera 14).
  • All cameras may be of the visible video type, or some may be filtered infrared (or other spectral filtered types) used with others of the visible video type.
  • the cameras 12 and 16 used for tracking are infrared filtered cameras; while the additional video camera 14 observes the visual spectmm. Accordingly, offering a comparison between the views provided by the separate cameras is a useful quality assurance check of the integrity of the entire tracking system.
  • FIGURE 6 another embodiment of the present invention involves a battery-powered optically detectable index stmcture 280 associated with an instnce 282.
  • a camera system 284 comprises three cameras 286, 288, and 290, which in the disclosed embodiment are linear infrared CCD cameras (see for example the IGT product, Boulder, Colorado). Data signals are processed by a processor 292, and these can be sent to a computer system, as described above (see FIGURE 1).
  • the instmment 282 is shown generically; the optical index stmcture 280 comprises LED emitters 294, 296, and 298 which in a prefe ⁇ ed embodiment are of an infrared-emitting type.
  • the emitters 294, 296, and 298 define a plane of light which can be transformed to specify the position of the instnce 282 to which they are attached.
  • the emitters 294, 296, and 298 are coupled to a circuit 300 which distributes energy to the LEDs for their illumination.
  • the circuit 300 controls the sequence and synchronization of LED lighting.
  • a battery 302 is provided to supply power to the circuit
  • the LED emitters 294, 296, and 298 are flashed in a coded sequence controlled by the circuit 300 that is detectable by the processor 292 so as to recognize the instmment 282 and the index stmcture 280.
  • the pattern of positions of the emitters 294, 296, and 298 can be used to allow the processor 292 to discriminate what specific instlement 282 is being used.
  • a coding scheme can be sent from a transmitter 304 to a receiver 306 coupled to the instnce 282.
  • the receiver 306 accepts light or radio wave signals from the transmitter 304, which is connected to the processor 292.
  • a synchronization signal representative of the shutter operation from the cameras 286, 288, and 290 is sent via the transmitter 304 (as shown by a dashed line 308) to the receiver 306.
  • the receiver 306 and the circuit 300 then cause the sequential flashing of the emitters 294, 296, and 298 detected by the cameras.
  • An optional return signal (represented by a dashed line 310) from the receiver 306 to the transmitter 304 can be used to confirm the synchronization of the emitters to the cameras.
  • a patient 312 may be in the surgical field with attached optically detectable index elements 314, 316, and 318, plus others as described above.
  • These light emitters may also be battery powered or wire powered from either batteries or another source.
  • the LED emitters 294, 296, and 298 do not consume much power if they are flashed intermittently, and thus the battery 302 comprises a standard type of battery, such as one that might be used to operate a flashlight, camera, or other small appliance. Such batteries can easily be replaced or sterilized at the time of surgery.
  • the use of batteries in a surgical instmment is advantageous in that the system is wireless and mechanically de-coupled from the camera system and its processor.
  • light sources may be used near to the cameras to produce reflected light from reflecting optically-detectable objects.
  • the optically detectable objects can alternatively have bright, colored, or shiny surfaces or have contrasting patterns of light and dark or alternately colored shapes and patterns to be detectable by cameras in ambient light.
  • the ambient light By arranging the ambient light to shine appropriately on a surgical, diagnostic, or therapeutic setting, objects can be recognized directly by the camera system 10 as shown in FIGURE 1.
  • the use of additional lights near the cameras can enhance the reflection from optically detectable objects in certain 21 clinical settings where ambient light may not be sufficient, or where high degrees of light contrast, such as from surgical head holders, microscope lights, or operating theatre lights may cause difficulty in discriminating light levels from the detectable objects.
  • various illumination possibilities can easily be devised in accordance with the present invention to facilitate detection and data processing of the camera and video information to suit the clinical context.
  • a camera and light reflection processing function specifies that the camera system 10 (FIGURE 1) detects an instmment with an optically detectable object attached to it. This is done with a camera system as described above, wherein camera data from infrared filtered cameras of various kinds and/or video cameras is provided to a pattem data processing function (block 322).
  • the pattem data processing function 322 receives data from the camera and light reflection processing function 320, allowing the instmment is recognized by pattern recognition algorithms operating on stereoscopic data received from the camera system 10.
  • the nature of the instmment can also be recognized by way of time or geometric sequencing or arrangements of light-emitting or light reflecting objects or patterns on the instmment, as described above.
  • a visible video camera may also be used in combination with filtered or unfiltered cameras as a confirmational step.
  • a video processing function (block 324) is provided to carry out the reception and processing of such visible video data.
  • the output data from such video processing is sent to a computer processing function (block 326), along with the instmment tracking data from the pattem data processing function 322.
  • the computer processing function 326 may also accept image scan data which is either taken prior to operation or contemporaneously during the operation, as illustrated by an image data processing function (block 328).
  • the computer processing function 326 can then combine or merge a combination of pattem recognition and tracking data (from the pattem data processing function 322), the visible video data (from the video processing function 324), and image scan data (from the image data processing function 328), so as to display it in various forms via a display function
  • a useful quality assurance check would be, for example, to overlay visible video data onto the combined representations of the image scan data and of the surgical instmment as it moves relative to the anatomy.
  • the video data shows in real time the position of an instmment relative to the anatomy, or the relative position of instments relative to each other, within the field of surgical view.
  • a rendering of the reconstmcted position of a surgical instmment relative to the overlaid anatomy, or compared side-by-side to the actual visible video view of the instmment relative to the anatomy is a strong confirmational step to show that the tracking is being done properly.
  • FIGURE 7 can apply to camera and video detection in the surgical setting, a diagnostic suite, or in connection with treatment planning process and instrumentation.
  • a real time diagnostic or intraoperative imaging machine such as a CT, MR, PET, X-ray, or other scanner would be another context for the process in FIGURE 7.
  • a patient registration data processing function (block 332), which represents the step of registering or calibrating instemperation or apparatus relative to a patient, prior to performing a procedure with the tracked instnce.
  • the registration step may be predetermined or determined during the clinical setting in a variety of ways, as described above.
  • a set of multiple camera images (stereoscopic images for the case of two or more two-dimensional cameras) is acquired (step 340) from the camera system 10 (FIGURE 1). Any markers present in the stereoscopic images are then detected (step 342) as described above. For example, when two two-dimensional CCD cameras are used, there are two frames in a set of stereoscopic images, namely a left frame (from the left camera 16) and a right frame (from the right camera 12). The detected markers will appear in slightly different positions in the two frames, so the positions are then correlated (step 344).
  • the difference in a marker's position between the two frames is used to determine depth (i.e., distance from the camera system 10) 23 in three dimensions. It should be noted that more than two cameras may be used in the present invention; the additional cameras can be used to verify the stereoscopic images or to provide further accuracy or definition.
  • the images are further processed to determine the positions of the markers in three-dimensional space by transforming the markers (step 346) into a coordinate system defined by the camera system 10.
  • this step is performed in varying ways depending on the nature of the markers in the field of view. For example, a spherical marker will define a centroid, while a rod-shaped or flat marker will define an axis. Accordingly, the unique set of centroids, axes, and other characteristics in the coordinate system of the cameras can be used to identify the position of the object being tracked (step 348). This information is used in the operation of the system as described below.
  • FIGURE 9 illustrates, in one exemplary embodiment, how the various objects are tracked by the system to generate one or more displays, as described above.
  • the location of the surgical instmment 60 (FIGURE 1) is identified with respect to the camera system 10, as described in conjunction with FIGURE 8.
  • a set of coordinates is generated thereby.
  • Those coordinates specify the position of the instmment 60, and further specify a transformation between the coordinate system of the camera system 10 and a coordinate system associated with the instmment. This may involve, for example, index point registrations from the patient's physical anatomy to image scan data, as described previously.
  • the location of the patient 22 is identified (step 352) with respect to the camera system 10.
  • the coordinates specify the position of the patient 22 and a coordinate transformation between the camera system and the patient.
  • the location of the surgeon 76 is identified (step 354), as above.
  • the display can comprise only a reproduction of the instmment in relation to a reproduction of the patient's anatomical stmctures (for example, based on reconstructions from image scan data from CT, MR, or other types of scans), or can include an overlaid video view from a video camera 14 on the camera system 10 or a video camera 82 on the surgeon 76.
  • the patient's anatomical data can be manipulated in various ways well known in the art to provide slice, cutaway, or contour views, among others.
  • Steps 350-362 are repeated as necessary to update the display with the various object positions in real time or close to real time.

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2652928B1 (fr) 1989-10-05 1994-07-29 Diadix Sa Systeme interactif d'intervention locale a l'interieur d'une zone d'une structure non homogene.
US6226548B1 (en) 1997-09-24 2001-05-01 Surgical Navigation Technologies, Inc. Percutaneous registration apparatus and method for use in computer-assisted surgical navigation
US6021343A (en) 1997-11-20 2000-02-01 Surgical Navigation Technologies Image guided awl/tap/screwdriver
US11331150B2 (en) 1999-10-28 2022-05-17 Medtronic Navigation, Inc. Method and apparatus for surgical navigation
US8644907B2 (en) 1999-10-28 2014-02-04 Medtronic Navigaton, Inc. Method and apparatus for surgical navigation
FR2801185A1 (fr) * 1999-11-18 2001-05-25 Francois Fassi Allouche Video endoscope securise a profilometre laser integre pour la chirurgie assistee par ordinateur
WO2001037748A2 (en) * 1999-11-29 2001-05-31 Cbyon, Inc. Method and apparatus for transforming view orientations in image-guided surgery
DE19960020A1 (de) * 1999-12-13 2001-06-21 Ruediger Marmulla Vorrichtung zur optischen Erfassung und Referenzierung zwischen Datensatz, Operationssitus und 3D-Markersystem zur Instrumenten- und Knochensegmentnavigation
WO2001064124A1 (en) 2000-03-01 2001-09-07 Surgical Navigation Technologies, Inc. Multiple cannula image guided tool for image guided procedures
EP1142536B1 (de) * 2000-04-05 2002-07-31 BrainLAB AG Referenzierung eines Patienten in einem medizinischen Navigationssystem mittels aufgestrahlter Lichtpunkte
EP1274360A1 (de) * 2000-04-10 2003-01-15 2C3D S.A. Medizinische vorrichtung zum projektieren von informationen auf intraoperativ erhaltene bilder
US6928742B2 (en) 2000-08-31 2005-08-16 Plus Orthopedics Ag Method and apparatus for finding the position of a mechanical axis of a limb
DE10047698A1 (de) * 2000-09-25 2002-04-11 Zeiss Carl Medizinisches Therapie- und/oder Diagnosegerät mit einer Positionserfassungseinrichtung
DE10065070B4 (de) * 2000-12-21 2004-08-26 Iom Innovative Optische Messtechnik Gmbh Vorrichtung und Verfahren zur Bestimmung von Ort und Lage einer Ultraschallgeberfläche im Raum
DE10105822C2 (de) * 2001-02-07 2003-02-06 Aesculap Ag & Co Kg Verfahren und Vorrichtung zur Bestimmung der Kontur einer Ausnehmung in einem Materialstück
DE10110093A1 (de) * 2001-03-02 2002-09-26 Juergen Wahrburg Vorrichtung zum Anzeigen der räumlichen Position eines chirurgischen Instruments während einer Operation
DE50214535D1 (de) 2001-03-26 2010-08-26 All Of Innovation Ges Mit Besc Verfahren und gerätesystem zum materialabtrag oder zur materialbearbeitung
DE10115170B8 (de) * 2001-03-28 2005-01-27 Lb Medical Gmbh Verfahren und System zur automatisierten Einmessung von navigierten Handstücken und Werkzeugen in der Medizin
US6636757B1 (en) 2001-06-04 2003-10-21 Surgical Navigation Technologies, Inc. Method and apparatus for electromagnetic navigation of a surgical probe near a metal object
WO2003002011A1 (en) * 2001-06-28 2003-01-09 Surgyvision Ltd. Stereoscopic video magnification and navigation system
DE10136709B4 (de) * 2001-07-27 2004-09-02 Siemens Ag Vorrichtung zum Durchführen von operativen Eingriffen sowie Verfahren zum Darstellen von Bildinformationen während eines solchen Eingriffs an einem Patienten
ATE387892T1 (de) 2001-10-10 2008-03-15 Brainlab Ag Medizinisches instrument mit berührungsempfindlicher spitze
DE10204430A1 (de) * 2002-02-04 2003-08-07 Zeiss Carl Stereo-Mikroskopieverfahren und Stereo-Mikroskopiesystem
DE10300925B4 (de) * 2002-02-04 2020-02-27 Carl Zeiss Meditec Ag Stereo-Untersuchungsvorrichtung und Stereo-Bilderzeugungsvorrichtung mit einer solchen
US6947786B2 (en) 2002-02-28 2005-09-20 Surgical Navigation Technologies, Inc. Method and apparatus for perspective inversion
US6741883B2 (en) * 2002-02-28 2004-05-25 Houston Stereotactic Concepts, Inc. Audible feedback from positional guidance systems
US6990368B2 (en) 2002-04-04 2006-01-24 Surgical Navigation Technologies, Inc. Method and apparatus for virtual digital subtraction angiography
US7998062B2 (en) 2004-03-29 2011-08-16 Superdimension, Ltd. Endoscope structures and techniques for navigating to a target in branched structure
DE10225077B4 (de) * 2002-06-05 2007-11-15 Vr Magic Gmbh Objektverfolgeanordnung für medizinische Operationen
AU2003257321A1 (en) * 2002-08-16 2004-03-03 Orthosoft Inc. Interface apparatus for passive tracking systems and method of use thereof
US6892090B2 (en) * 2002-08-19 2005-05-10 Surgical Navigation Technologies, Inc. Method and apparatus for virtual endoscopy
DE10246147B4 (de) * 2002-10-01 2007-12-06 Vr Magic Gmbh Mehrkamera-Trackingsystem
DE10259250A1 (de) * 2002-12-17 2004-07-01 "Stiftung Caesar" (Center Of Advanced European Studies And Research) Chirurgisches Instrument mit integrierter Navigationskontrolle
US7660623B2 (en) 2003-01-30 2010-02-09 Medtronic Navigation, Inc. Six degree of freedom alignment display for medical procedures
US7492930B2 (en) * 2003-02-04 2009-02-17 Aesculap Ag Method and apparatus for capturing information associated with a surgical procedure performed using a localization device
US7831295B2 (en) 2003-06-05 2010-11-09 Aesculap Ag & Co. Kg Localization device cross check
US7369101B2 (en) 2003-06-12 2008-05-06 Siemens Medical Solutions Usa, Inc. Calibrating real and virtual views
DE10331885A1 (de) * 2003-07-14 2005-02-10 Aesculap Ag & Co. Kg Markierelement für ein chirurgisches Navigationssystem
US20050049485A1 (en) * 2003-08-27 2005-03-03 Harmon Kim R. Multiple configuration array for a surgical navigation system
DE602004022432D1 (de) 2003-09-15 2009-09-17 Super Dimension Ltd System aus zubehör zur verwendung mit bronchoskopen
EP2316328B1 (de) 2003-09-15 2012-05-09 Super Dimension Ltd. Umhüllungsvorrichtung zur Fixierung von Bronchoskopen
DE10343826B4 (de) * 2003-09-22 2006-02-09 Plus-Endoprothetik Ag Knochenfester Lokator und Navigationssystem
US8764725B2 (en) 2004-02-09 2014-07-01 Covidien Lp Directional anchoring mechanism, method and applications thereof
DE102004029847B4 (de) * 2004-06-15 2013-04-18 Aesculap Ag Chirurgisches Instrument und chirurgisches Navigationssystem
DE102004035883B4 (de) * 2004-07-23 2006-08-31 Aesculap Ag & Co. Kg Marker sowie Reflektorelement für einen Marker eines chirurgischen Navigationssystems sowie Verfahren zum Versehen eines Markers mit einer Reflektorschicht
US10555775B2 (en) 2005-05-16 2020-02-11 Intuitive Surgical Operations, Inc. Methods and system for performing 3-D tool tracking by fusion of sensor and/or camera derived data during minimally invasive robotic surgery
DE102005026654A1 (de) * 2005-06-09 2006-12-14 Ife Industrielle Forschung Und Entwicklung Gmbh Vorrichtung und Verfahren zur berührungslosen Vermessung der Geometrie, Raumposition und Raumorientierung von Körpern
DE102005045706B3 (de) * 2005-09-20 2007-04-26 Aesculap Ag & Co. Kg Chirurgisches Markerelement, chirurgisches Referenzelement und chirurgisches Navigationssystem
KR20080081907A (ko) 2005-11-03 2008-09-10 오르소소프트 인코포레이티드 컴퓨터 지원 수술용 다면 트래커 장치
US9168102B2 (en) 2006-01-18 2015-10-27 Medtronic Navigation, Inc. Method and apparatus for providing a container to a sterile environment
US9636188B2 (en) * 2006-03-24 2017-05-02 Stryker Corporation System and method for 3-D tracking of surgical instrument in relation to patient body
PL2023812T3 (pl) 2006-05-19 2017-07-31 The Queen's Medical Center Układ śledzenia ruchu dla adaptacyjnego obrazowania w czasie rzeczywistym i spektroskopii
US8660635B2 (en) 2006-09-29 2014-02-25 Medtronic, Inc. Method and apparatus for optimizing a computer assisted surgical procedure
US9220573B2 (en) * 2007-01-02 2015-12-29 Medtronic Navigation, Inc. System and method for tracking positions of uniform marker geometries
EP1952779B1 (de) 2007-02-01 2012-04-04 BrainLAB AG Medizintechnische Instrumenten-Identifizierung
US8905920B2 (en) 2007-09-27 2014-12-09 Covidien Lp Bronchoscope adapter and method
WO2009122273A2 (en) 2008-04-03 2009-10-08 Superdimension, Ltd. Magnetic interference detection system and method
US8473032B2 (en) 2008-06-03 2013-06-25 Superdimension, Ltd. Feature-based registration method
US8218847B2 (en) 2008-06-06 2012-07-10 Superdimension, Ltd. Hybrid registration method
US8932207B2 (en) 2008-07-10 2015-01-13 Covidien Lp Integrated multi-functional endoscopic tool
US9248000B2 (en) 2008-08-15 2016-02-02 Stryker European Holdings I, Llc System for and method of visualizing an interior of body
WO2010020397A1 (de) * 2008-08-18 2010-02-25 Naviswiss Ag Medizinisches messsystem, verfahren zum chirurgischen eingriff sowie die verwendung eines medizinischen messsystems
US8611984B2 (en) 2009-04-08 2013-12-17 Covidien Lp Locatable catheter
FR2945127B1 (fr) 2009-04-30 2012-03-30 Thales Sa Procede et dispositif de detection optique des mouvements d'un solide dans l'espace
US10582834B2 (en) 2010-06-15 2020-03-10 Covidien Lp Locatable expandable working channel and method
US8657809B2 (en) 2010-09-29 2014-02-25 Stryker Leibinger Gmbh & Co., Kg Surgical navigation system
WO2013032933A2 (en) 2011-08-26 2013-03-07 Kinecticor, Inc. Methods, systems, and devices for intra-scan motion correction
EP2869780B1 (de) * 2012-07-03 2018-11-28 7D Surgical Inc. Befestigungen zur verfolgung von tragbaren instrumenten
CN105338897B (zh) * 2013-01-24 2019-06-14 凯内蒂科尔股份有限公司 用于在医学成像扫描期间追踪和补偿患者运动的系统、设备和方法
US9717461B2 (en) 2013-01-24 2017-08-01 Kineticor, Inc. Systems, devices, and methods for tracking and compensating for patient motion during a medical imaging scan
US10327708B2 (en) 2013-01-24 2019-06-25 Kineticor, Inc. Systems, devices, and methods for tracking and compensating for patient motion during a medical imaging scan
US9305365B2 (en) 2013-01-24 2016-04-05 Kineticor, Inc. Systems, devices, and methods for tracking moving targets
US9782141B2 (en) 2013-02-01 2017-10-10 Kineticor, Inc. Motion tracking system for real time adaptive motion compensation in biomedical imaging
EP3019109B1 (de) 2013-07-08 2022-09-28 Brainlab AG Single-marker-navigation
WO2015022022A1 (en) 2013-08-13 2015-02-19 Brainlab Ag Digital tool and method for planning knee replacement
EP3035882B1 (de) 2013-08-13 2018-03-28 Brainlab AG Moiré-markervorrichtung zur medizinischen navigation
EP3107476B1 (de) 2014-02-21 2024-04-24 The University of Akron Abbildungs- und anzeigesystem zur führung von medizinischen eingriffen
EP3157422A4 (de) 2014-03-24 2018-01-24 The University of Hawaii Systeme, verfahren und vorrichtungen zur entfernung von prospektiver bewegungskorrektur von medizinischen bildgebungsscans
US10952593B2 (en) 2014-06-10 2021-03-23 Covidien Lp Bronchoscope adapter
WO2016014718A1 (en) 2014-07-23 2016-01-28 Kineticor, Inc. Systems, devices, and methods for tracking and compensating for patient motion during a medical imaging scan
KR20220166880A (ko) 2014-11-21 2022-12-19 씽크 써지컬, 인크. 시각 추적 시스템과 추적 마커 간에 데이터를 전송하기 위한 가시광 통신 시스템
US10426555B2 (en) 2015-06-03 2019-10-01 Covidien Lp Medical instrument with sensor for use in a system and method for electromagnetic navigation
EP3325227B1 (de) * 2015-07-17 2022-06-22 Apex Brands, Inc. Sichtsystem mit automatischer kalibrierung
US9943247B2 (en) 2015-07-28 2018-04-17 The University Of Hawai'i Systems, devices, and methods for detecting false movements for motion correction during a medical imaging scan
CN109938839B (zh) * 2015-08-31 2024-03-26 北京天智航医疗科技股份有限公司 一种用于导航手术的光学跟踪工具
US9962134B2 (en) 2015-10-28 2018-05-08 Medtronic Navigation, Inc. Apparatus and method for maintaining image quality while minimizing X-ray dosage of a patient
US10716515B2 (en) 2015-11-23 2020-07-21 Kineticor, Inc. Systems, devices, and methods for tracking and compensating for patient motion during a medical imaging scan
CN108778178B (zh) * 2015-12-18 2021-10-01 皇家飞利浦有限公司 用于医学仪器跟踪的系统和方法
US10743901B2 (en) * 2015-12-29 2020-08-18 Ethicon Llc Snap fit clamp pad for ultrasonic surgical instrument
CA3005502C (en) * 2016-03-17 2021-03-30 Brainlab Ag Optical tracking
US10478254B2 (en) 2016-05-16 2019-11-19 Covidien Lp System and method to access lung tissue
US10638952B2 (en) 2016-10-28 2020-05-05 Covidien Lp Methods, systems, and computer-readable media for calibrating an electromagnetic navigation system
US10517505B2 (en) 2016-10-28 2019-12-31 Covidien Lp Systems, methods, and computer-readable media for optimizing an electromagnetic navigation system
US10615500B2 (en) 2016-10-28 2020-04-07 Covidien Lp System and method for designing electromagnetic navigation antenna assemblies
US10792106B2 (en) 2016-10-28 2020-10-06 Covidien Lp System for calibrating an electromagnetic navigation system
US10751126B2 (en) 2016-10-28 2020-08-25 Covidien Lp System and method for generating a map for electromagnetic navigation
US10722311B2 (en) 2016-10-28 2020-07-28 Covidien Lp System and method for identifying a location and/or an orientation of an electromagnetic sensor based on a map
US10446931B2 (en) 2016-10-28 2019-10-15 Covidien Lp Electromagnetic navigation antenna assembly and electromagnetic navigation system including the same
US10418705B2 (en) 2016-10-28 2019-09-17 Covidien Lp Electromagnetic navigation antenna assembly and electromagnetic navigation system including the same
US11219489B2 (en) 2017-10-31 2022-01-11 Covidien Lp Devices and systems for providing sensors in parallel with medical tools
EP3545896A1 (de) * 2018-03-30 2019-10-02 Koninklijke Philips N.V. Überwachung von bewegten objekten in einem operationssaal
EP3685785A1 (de) 2019-01-22 2020-07-29 Stryker European Holdings I, LLC Verfolger für ein chirurgisches navigationssystem
WO2021125996A1 (ru) * 2019-12-18 2021-06-24 Ахмеджан Атаханович АЛЛАБЕРГАНОВ Многофункциональный биолого-видеомикроскопический спектральный комплекс
CN111388087A (zh) * 2020-04-26 2020-07-10 深圳市鑫君特智能医疗器械有限公司 手术导航系统及执行手术导航方法的计算机与存储介质
EP3970640A1 (de) * 2020-09-18 2022-03-23 Stryker European Operations Limited Chirurgische vorrichtung mit beweglichem nachführer
EP4056141A1 (de) * 2021-03-08 2022-09-14 Stryker European Operations Limited Gedruckter verfolger für ein chirurgisches navigationssystem
CN113194337B (zh) * 2021-04-29 2022-01-04 深圳鸿祥源科技有限公司 一种基于5g网络的手持视频采集终端系统及其采集方法
EP4085865A1 (de) * 2021-05-04 2022-11-09 Stryker European Operations Limited Chirurgischer verfolger mit durch elektromagnetische strahlung ausgelösten emittern

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4608977A (en) 1979-08-29 1986-09-02 Brown Russell A System using computed tomography as for selective body treatment
DE3636671A1 (de) * 1986-09-11 1988-03-17 Neumeyer Stefan Verfahren zur dreidimensionalen bestimmung der relativbewegung zwischen zwei koerpern sowie messanordnung zur durchfuehrung dieses verfahrens
US4797736A (en) * 1987-09-02 1989-01-10 Luxtec Corporation Head mounted illumination and camera assembly
US6006126A (en) * 1991-01-28 1999-12-21 Cosman; Eric R. System and method for stereotactic registration of image scan data
EP0700269B1 (de) * 1993-04-22 2002-12-11 Image Guided Technologies, Inc. Anordnung zur bestimmung der gegenseitigen lage von körpern
IL109939A (en) * 1993-06-21 1997-09-30 Gen Electric Display system for enhancing visualization of body structures during medical procedures
US5446548A (en) * 1993-10-08 1995-08-29 Siemens Medical Systems, Inc. Patient positioning and monitoring system
US5491510A (en) * 1993-12-03 1996-02-13 Texas Instruments Incorporated System and method for simultaneously viewing a scene and an obscured object
GB9405299D0 (en) * 1994-03-17 1994-04-27 Roke Manor Research Improvements in or relating to video-based systems for computer assisted surgery and localisation
ATE228338T1 (de) * 1994-10-07 2002-12-15 Univ St Louis Chirurgische navigationsanordnung einschliesslich referenz- und ortungssystemen
DE29505318U1 (de) * 1995-03-29 1995-05-18 Carl Zeiss, 89518 Heidenheim Vorrichtung zur Markierung von optisch zu vermessenden Punkten
US5776050A (en) * 1995-07-24 1998-07-07 Medical Media Systems Anatomical visualization system
JPH11510423A (ja) * 1996-05-29 1999-09-14 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 画像誘導手術システム
CH690707A5 (de) * 1996-06-10 2000-12-29 Leica Mikroskopie Sys Ag Marker zur Positionserfassung mit elektrischen bzw. elektronischen Licht-Sendeelementen
DE19709960A1 (de) * 1997-03-11 1998-09-24 Aesculap Ag & Co Kg Verfahren und Vorrichtung zur präoperativen Bestimmung der Positionsdaten von Endoprothesenteilen

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9938449A1 *

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