EP1034277B1 - Extrazelluläre Matrix-bindende Proteine von Staphylococcus aureus - Google Patents
Extrazelluläre Matrix-bindende Proteine von Staphylococcus aureus Download PDFInfo
- Publication number
- EP1034277B1 EP1034277B1 EP98959613A EP98959613A EP1034277B1 EP 1034277 B1 EP1034277 B1 EP 1034277B1 EP 98959613 A EP98959613 A EP 98959613A EP 98959613 A EP98959613 A EP 98959613A EP 1034277 B1 EP1034277 B1 EP 1034277B1
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- Prior art keywords
- clfb
- protein
- aureus
- proteins
- binding
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- Medicinal Chemistry (AREA)
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- Peptides Or Proteins (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Claims (24)
- Isoliertes Nucleinsäuremolekül, das für ein Fibrinogen bindendes Protein kodiert, worin die Nucleinsäure für die Aminosäuresequenz von Seq.-ID Nr. 1 kodiert.
- Isolierte Nucleinsäure nach Anspruch 1, umfassend die Sequenz von Seq.-ID Nr. 2.
- Vektor, umfassend die isolierte Nucleinsäure nach Anspruch 1 oder Anspruch 2.
- Vektor nach Anspruch 3 in einem Mikroorganismus, der in der Lage ist, die Nucleinsäure zu exprimieren.
- Isoliertes Nucleinsäuremolekül nach Anspruch 1 oder Anspruch 2, kodierend für ein extrazelluläre Matrix bindendes Protein, das ein TYTFTDYVD-Motiv aufweist, worin das Protein von S. aureus isoliert und nicht ClfA ist.
- Vektor, der die isolierte Nucleinsäure nach Anspruch 5 umfasst.
- Vektor nach Anspruch 6 in einem Mikroorganismus, der in der Lage ist, die isolierte Nucleinsäure zu exprimieren.
- Isoliertes, rekombinantes oder synthetisches Protein, worin das Protein eine Aminosäuresequenz aufweist, die die Sequenz von Seq.-ID Nr. 1 umfasst.
- Protein nach Anspruch 8, für das eine Nucleinsäuresequenz kodiert, die die Sequenz von Seq.-ID Nr. 2 umfasst.
- Protein nach Anspruch 8, exprimiert von einem Vektor in einem lebenden Organismus, worin der Vektor eine Nucleinsäuresequenz enthält, die die Sequenz von Seq.-ID Nr. 2 umfasst.
- Isoliertes, rekombinantes oder synthetisches Protein nach Anspruch 8, das kationenabhängige Ligandenbindung aufweist und ein Consensus-TYTFTDYVD-Motiv aufweist, worin das Protein von S. aureus isoliert und nicht ClfA ist.
- Protein nach einem der Ansprüche 8 bis 11 in einem pharmazeutisch annehmbaren Träger.
- Protein nach Anspruch 12 in einem pharmazeutisch annehmbaren Träger.
- Protein nach einem der Ansprüche 8 bis 11, immobilisiert auf einer Festphase.
- Isolierter Antikörper oder isoliertes Antikörperfragment zur Sequenz TYTFTDYVD.
- Diagnoseset, umfassend ein Protein mit einer Aminosäuresequenz der Seq.-ID Nr. 1 oder ein Proteinfragment davon, das ein Consensus-TYTFTDYVD-Motiv aufweist, worin das Protein von S. aureus isoliert und nicht ClfA ist.
- Diagnoseset, umfassend einen Antikörper oder ein Antikörperfragment nach Anspruch 15.
- Protein nach einem der Ansprüche 8 bis 11 zur Verwendung bei der Behandlung einer S.-aureus-Infektion bei einem Patienten.
- Protein nach Anspruch 18, worin die Infektion Septikämie, Osteomyelitis, Mastitis oder Endocarditis ist.
- Protein nach einem der Ansprüche 8 bis 11 zur Verwendung in einem Verfahren zur Hemmung der Bindung von S. aureus an die extrazelluläre Matrix, um eine S.-aureus-Infektion bei einem Patienten zu behandeln oder ihr vorzubeugen.
- Wirksame Menge einer pharmazeutischen Zusammensetzung, die einen Antikörper oder ein Antikörperfragment nach Anspruch 15 umfasst, zur Verwendung in einem Verfahren zur Behandlung oder Prävention einer S.-aureus-Infektion bei einem Patienten.
- Zusammensetzung, umfassend ein Protein nach einem der Ansprüche 8 bis 11, zur Verwendung beim Überzug einer medizinischen Vorrichtung zum Reduzieren der S.-aureus-Infektion einer implantierten medizinischen Vorrichtung.
- Zusammensetzung nach Anspruch 22, worin die medizinische Vorrichtung aus der aus Gefäßtransplantaten, Gefäßstents, intravenösen Kathetern, künstlichen Herzklappen und Herzschrittmachern bestehenden Gruppe ausgewählt ist.
- Zusammensetzung, umfassend ein Protein nach einem der Ansprüche 8 bis 11, zur Verwendung als Impfstoff.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10182690A EP2319931A1 (de) | 1997-11-26 | 1998-11-25 | Extrazellulären Matrix-bindende Proteine von Staphilococcus aureus |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6681597P | 1997-11-26 | 1997-11-26 | |
US66815P | 1997-11-26 | ||
US9842798P | 1998-08-31 | 1998-08-31 | |
US98427P | 1998-08-31 | ||
PCT/US1998/025246 WO1999027109A2 (en) | 1997-11-26 | 1998-11-25 | EXTRACELLULAR MATRIX-BINDING PROTEINS FROM $i(STAPHYLOCOCCUS AUREUS) |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
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EP10182690.7 Division-Into | 2010-09-29 |
Publications (2)
Publication Number | Publication Date |
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EP1034277A2 EP1034277A2 (de) | 2000-09-13 |
EP1034277B1 true EP1034277B1 (de) | 2012-06-27 |
Family
ID=26747174
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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EP98959613A Expired - Lifetime EP1034277B1 (de) | 1997-11-26 | 1998-11-25 | Extrazelluläre Matrix-bindende Proteine von Staphylococcus aureus |
EP10182690A Withdrawn EP2319931A1 (de) | 1997-11-26 | 1998-11-25 | Extrazellulären Matrix-bindende Proteine von Staphilococcus aureus |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP10182690A Withdrawn EP2319931A1 (de) | 1997-11-26 | 1998-11-25 | Extrazellulären Matrix-bindende Proteine von Staphilococcus aureus |
Country Status (5)
Country | Link |
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EP (2) | EP1034277B1 (de) |
JP (2) | JP4486748B2 (de) |
AU (1) | AU1537699A (de) |
CA (1) | CA2310217A1 (de) |
WO (1) | WO1999027109A2 (de) |
Families Citing this family (35)
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US6933366B2 (en) | 1996-12-27 | 2005-08-23 | Tripep Ab | Specificity exchangers that redirect antibodies to bacterial adhesion receptors |
US6660842B1 (en) | 1994-04-28 | 2003-12-09 | Tripep Ab | Ligand/receptor specificity exchangers that redirect antibodies to receptors on a pathogen |
DE69940404D1 (de) * | 1998-08-31 | 2009-03-26 | Inhibitex Inc | Multikomponenten Impfstoffe gegen Staphylococcus aureus |
US6692739B1 (en) | 1998-08-31 | 2004-02-17 | Inhibitex, Inc. | Staphylococcal immunotherapeutics via donor selection and donor stimulation |
EP1121149A4 (de) * | 1998-08-31 | 2002-03-20 | Inhibitex Inc | Immunotherapeutika gegen staphylokokkus mittels donor selektion und donor stimulation |
MXPA01002120A (es) * | 1998-08-31 | 2003-03-27 | Trinity College Dublin | Polipeptidos y polinucleotidos de estafilococo negativo a coagulasa. |
WO2002102829A2 (en) * | 2001-06-15 | 2002-12-27 | Inhibitex, Inc. | Cross-reactive monoclonal and polyclonal antibodies which recognize surface proteins from coagulase-negative staphylococci and staphylococcus aureus |
US7335359B2 (en) | 2003-02-06 | 2008-02-26 | Tripep Ab | Glycosylated specificity exchangers |
JP2007516157A (ja) | 2003-02-06 | 2007-06-21 | トリペップ アクチ ボラゲット | グリコシル化された抗原/抗体又はリガンド/受容体特異性交換体 |
JP4836795B2 (ja) * | 2003-05-19 | 2011-12-14 | ブランデイズ ユニバーシティー | 核酸プロセシング方法、キット、及び装置 |
WO2004110367A2 (en) * | 2003-05-29 | 2004-12-23 | Inhibitex, Inc. | Sdr proteins from staphylococcus capitis and their use in preventing and treating infections |
ES2472441T3 (es) | 2004-09-22 | 2014-07-01 | Glaxosmithkline Biologicals S.A. | Composición inmunog�nica para uso en vacunación contra estafilococos |
JP2009531387A (ja) | 2006-03-30 | 2009-09-03 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 免疫原性組成物 |
WO2009029831A1 (en) | 2007-08-31 | 2009-03-05 | University Of Chicago | Methods and compositions related to immunizing against staphylococcal lung diseases and conditions |
US9181329B2 (en) | 2007-08-31 | 2015-11-10 | The University Of Chicago | Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions |
US8466167B2 (en) | 2008-03-03 | 2013-06-18 | Irm Llc | Compounds and compositions as TLR activity modulators |
WO2010014304A1 (en) | 2008-07-29 | 2010-02-04 | University Of Chicago | Compositions and methods related to staphylococcal bacterium proteins |
HUE057713T2 (hu) | 2009-04-03 | 2022-05-28 | Univ Chicago | A protein A (SPA) variánsaival kapcsolatos készítmények és módszerek |
CA2765112A1 (en) | 2009-06-10 | 2010-12-16 | Novartis Ag | Benzonaphthyridine-containing vaccines |
SG10201406432RA (en) | 2009-06-22 | 2014-11-27 | Wyeth Llc | Compositions and methods for preparing staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions |
BRPI1015567A2 (pt) | 2009-06-22 | 2021-08-31 | Wyeth Llc | Composições imunogênicas de antígenos de staphylococcus aureus |
GB0913680D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
JO3257B1 (ar) | 2009-09-02 | 2018-09-16 | Novartis Ag | مركبات وتركيبات كمعدلات لفاعلية tlr |
ES2443952T3 (es) | 2009-09-02 | 2014-02-21 | Novartis Ag | Composiciones inmunógenas que incluyen moduladores de la actividad de TLR |
WO2011057148A1 (en) | 2009-11-05 | 2011-05-12 | Irm Llc | Compounds and compositions as tlr-7 activity modulators |
US9408907B2 (en) | 2009-12-15 | 2016-08-09 | Glaxosmithkline Biologicals Sa | Homogenous suspension of immunopotentiating compounds and uses thereof |
EP2549990A1 (de) | 2010-03-23 | 2013-01-30 | Irm Llc | Verbindungen (cysteinbasierte lipopeptide) und zusammensetzungen als tlr2-agonisten zur behandlung von infektionen, entzündungen, atemwegserkrankungen etc. |
WO2012003474A2 (en) | 2010-07-02 | 2012-01-05 | The University Of Chicago | Compositions and methods related to protein a (spa) variants |
US9192661B2 (en) | 2010-07-06 | 2015-11-24 | Novartis Ag | Delivery of self-replicating RNA using biodegradable polymer particles |
DK2654784T3 (en) | 2010-12-22 | 2017-02-13 | Wyeth Llc | STABLE IMMUNOGENIC COMPOSITIONS OF STAPHYLOCOCCUS AUREUS ANTIGENES |
US8945588B2 (en) | 2011-05-06 | 2015-02-03 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides |
CN105188747A (zh) | 2013-02-01 | 2015-12-23 | 葛兰素史密斯克莱生物公司 | 包含toll样受体激动剂的免疫组合物的皮内递送 |
KR101878529B1 (ko) * | 2014-09-25 | 2018-07-16 | 울산대학교 산학협력단 | 반코마이신 불균질 내성 황색포도알균 클론타입 판별용 바이오마커 조성물 및 이를 이용한 판별용 키트 |
US11458151B2 (en) | 2018-02-12 | 2022-10-04 | Inimmune Corporation | Toll-like receptor ligands |
CA3198924A1 (en) | 2020-11-04 | 2022-05-12 | Eligo Bioscience | Phage-derived particles for in situ delivery of dna payload into c. acnes population |
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US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
ATE214942T1 (de) * | 1992-09-21 | 2002-04-15 | Alfa Laval Agri Internat Ab | Fibrinogen-bildungsprotein |
EP0771351A1 (de) * | 1994-06-07 | 1997-05-07 | The Rockefeller University | Oberflächenprotein aus staphylococcus aureus |
US6737248B2 (en) * | 1996-01-05 | 2004-05-18 | Human Genome Sciences, Inc. | Staphylococcus aureus polynucleotides and sequences |
US5888971A (en) * | 1996-02-20 | 1999-03-30 | Ortho Pharmaceutical Corporation, Inc. | Macrocyclic peptides useful in the treatment of thrombin related disorders |
SE9602496D0 (sv) * | 1996-06-20 | 1996-06-20 | Bengt Guss | Method and means for producing a fibrinogen binding protein and its use in biotechnology |
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- 1998-11-25 EP EP10182690A patent/EP2319931A1/de not_active Withdrawn
- 1998-11-25 CA CA002310217A patent/CA2310217A1/en not_active Abandoned
- 1998-11-25 JP JP2000522250A patent/JP4486748B2/ja not_active Expired - Fee Related
- 1998-11-25 WO PCT/US1998/025246 patent/WO1999027109A2/en active Application Filing
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2010
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WO1999027109A3 (en) | 1999-09-02 |
WO1999027109A2 (en) | 1999-06-03 |
EP1034277A2 (de) | 2000-09-13 |
JP4486748B2 (ja) | 2010-06-23 |
CA2310217A1 (en) | 1999-06-03 |
EP2319931A1 (de) | 2011-05-11 |
JP2010178737A (ja) | 2010-08-19 |
JP2002505075A (ja) | 2002-02-19 |
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