Classifications

• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
  • C11D3/16—Organic compounds
  • C11D3/26—Organic compounds containing nitrogen
  • C11D3/28—Heterocyclic compounds containing nitrogen in the ring
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
  • C11D1/66—Non-ionic compounds
  • C11D1/83—Mixtures of non-ionic with anionic compounds
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
  • C11D1/02—Anionic compounds
  • C11D1/04—Carboxylic acids or salts thereof
  • C11D1/06—Ether- or thioether carboxylic acids
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
  • C11D1/66—Non-ionic compounds
  • C11D1/72—Ethers of polyoxyalkylene glycols
  • C11D1/721—End blocked ethers
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
  • C11D1/66—Non-ionic compounds
  • C11D1/722—Ethers of polyoxyalkylene glycols having mixed oxyalkylene groups; Polyalkoxylated fatty alcohols or polyalkoxylated alkylaryl alcohols with mixed oxyalkylele groups
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
  • C11D1/66—Non-ionic compounds
  • C11D1/75—Amino oxides

Definitions

• the invention relates to compositions comprising ether carboxylates, nonionic Surfactants and N-alkylpyrrolidones as well as other auxiliary substances.
• the compositions are characterized by a particular low foam level and at the same time lower Surface tension and high cleaning activity.
• the compositions do not contain cumene sulfonate as a solubilizer and can if necessary can also be formulated without solvents.
• the agents according to the invention become mechanical and manual cleaning of hard surfaces, especially of medical devices, surgical instruments, rigid and flexible Endoscopes, inventory and other inanimate surfaces are used.
• Surgical instruments are increasingly being machined today prepared special cleaning and disinfection machines.
• the cleaning step is particularly sensitive because it is residue-free Cleaning blood, secretion and protein contaminants prevents incrustations of residual contamination from the subsequent thermal or thermo-chemical Disinfection step. How difficult a mechanical residue-free Cleaning is actually done mostly on microsurgical Instruments and flexible endoscopes clearly, which is a complicated system of sometimes extremely narrow channels, branches and spindly cavities form.
• sensitive materials e.g. complicated optics, special adhesives, light guides, more sensitive to corrosion Metals and highly elastic plastics a particularly gentle treatment, the functionality of the sometimes very expensive devices even after many Processing cycles not to be affected.
• Alkaline cleaners attempt this task by adding active chlorine or to meet active oxygen compounds, which also without the addition of surfactants are able to solve protein contamination from surfaces.
• the disadvantage here is the high pH and the associated poor quality Material compatibility, especially compared to anodized aluminum, but also Nonferrous metals or special alloys. Therefore, in recent times, have increased mildly alkaline and pH neutral cleaners are suggested based on low-foam non-ionic and / or anionic surfactants are built up and Supporting the cleaning effect may contain proteolytic enzymes can.
• EP-A-0 268 227 describes a cleaning agent which contains at least one non-ionic low-foaming surfactant, complexing agents, proteolytic enzymes as well contains other detergent ingredients.
• nonionic surfactants Investment products of ethylene oxide and optionally propylene oxide saturated fatty alcohols claimed in which the terminal hydroxyl groups can be etherified, esterified or acetalized with an aliphatic alcohol.
• Comparable cleaning agents on this basis make themselves low Use the cloud point of the surfactants used.
• Such a detergent solution is usually clear at lower temperatures to become warm tarnish.
• This partial separation from the aqueous phase means that Surfactants mostly at temperatures above 25-30 ° C as foam inhibitors, see above that even mechanical cleaning processes with high turbulence without problems can be carried out.
• the aqueous phase becomes surface-active in this way Withdrawn substance, so that especially at higher temperatures 45 ° C increased wetting problems occur on the surfaces to be cleaned can and the cleaning effect of such a solution on the mechanical
• the strength of the solution remains limited. Provided the temperature of the cleaning solution but is still below the cloud point, can be in washing machines and disinfectors increased foaming occur, which in the case of cleaning from flexible endoscopes to automatic system shutdown and thus an interruption of the cleaning process due to pressure loss Can cause foaming.
• DE-A-196 07 530 describes a cleaner which, in addition to enzymes, complexing agents and other customary constituents, contains an anionic surfactant of the type of a short-chain C 5 -C 10 alkyl sulfate salt as the surfactant base. It is known that anionic surfactants have a good cleaning-supporting effect, surfactants with hydrophobic residues from 10 carbon atoms tend to form a lot of foam. If, as described in DE-A-196 07 530, surfactants with short-chain branched hydrophobic radicals are used, it is possible to produce formulations whose dilute solutions are characterized by a constant low foam formation over the entire temperature range, but strong in their wetting ability and cleaning activity to be desired.
• the surfactant base should have good biodegradability and for improvement no biologically hard fluorosurfactants are used come.
• the agent and its working solutions should preferably pH be neutral to slightly acidic to ensure optimal tolerance of the product and its solution compared to the usual flexible ones used in medicine Ensure plastic materials and metallic materials.
• alkyl polyglycol ether carboxylates The class of alkyl polyglycol ether carboxylates is known for its good cleaning properties with a relatively low to moderate tendency to foam. These products are commercially available from KAO Corporation under the collective name Akypo R LF.
• Akypo R LF The collective name of alkyl polyglycol ether carboxylates.
• initial attempts at formulation with octyl ether carboxylates showed that the cleaning solutions made from them tended to foam excessively.
• Attempts to contain the foam by using a blend with the particularly short-chain butyl ether carboxylate did not bring the hoped-for success, since the foam now disintegrated faster, but the initial foam height at time 0 remained almost unchanged.
• low-foam, storage-stable formulations that meet the requirements mentioned above if the mixtures contain at least one ether carboxylate, at least one contain nonionic surfactant and at least one N-alkylpyrrolidone.
• This composition can be present as a concentrate, which is in aqueous or aqueous-alcoholic Solution can be used (application solution).
• composition according to the invention is in a special embodiment free of difficult or non-degradable foam dampers, such as EO-PO block polymers in particular, Silicone derivatives and / or paraffin oil and solubilizers, such as in particular cumene or xylene sulfonates.
• difficult or non-degradable foam dampers such as EO-PO block polymers in particular, Silicone derivatives and / or paraffin oil and solubilizers, such as in particular cumene or xylene sulfonates.
• the ether carboxylates of the formula I are in the cleaning agent according to the invention preferably in a total concentration of 0.1-10% by weight, particularly preferably in a concentration of 0.1-7% by weight, based on the total amount of the concentrate included.
• the mono-, di- and trivalent metal ions can be, for example Act alkali and / or alkaline earth metal ions.
• the alkyl radical R 1 preferably contains 4-13, particularly preferably 4-10 carbon atoms.
• K preferably takes an integer between 0 and 9, particularly preferably between 5 and 9.
• a preferred ether carboxylate is sodium C 8 alkyl ether carboxylate (6 EO) (sodium capryleth (6) carboxylate).
• the nonionic surfactants of formula II are in the agent according to the invention preferably in a concentration of 0.1-30% by weight, particularly preferably in a concentration of 0.1-15 wt .-%, based on the total amount of Concentrate.
• M preferably takes an integer between 3 and 20 on.
• the particularly preferred nonionic surfactants are one Octyl ethoxylate with 6-10 EO, terminally sealed with an octylglyceryl ether, as it e.g. by HACOBA AG (Basel) under the trade name TN 55 ether surfactant is offered.
• N-alkylpyrrolidones in the agent according to the invention are preferably in a concentration of 0.01-15 wt .-%, particularly preferably in a concentration of 0.01-5 wt .-%, based on the total amount of the concentrate.
• the aqueous solution comprises at least a total 1.0% by weight of components (a), (b) and (c), based on the Total amount of solution.
• the 100% by weight missing part can be replaced by the optional mentioned below Components and water are added.
• the cleaning agent can additionally 0.1-30 wt .-%, preferably 0.5-20 Wt .-% contain complexing agents and water hardness stabilizers, with salts organic acids, e.g. Salts of citric acid, gluconic acid, nitrilotriacetic acid, EDTA, aminotrismethylenephosphonic acid, hydroxyethane diphosphonic acid, Phosphonobutane tricarboxylic acid, but also polymers, e.g. Polyacrylates, polycarboxylates, Maleic acid / acrylic acid copolymers or mixtures thereof for Can come into play.
• salts organic acids e.g. Salts of citric acid, gluconic acid, nitrilotriacetic acid, EDTA, aminotrismethylenephosphonic acid, hydroxyethane diphosphonic acid, Phosphonobutane tricarboxylic acid
• polymers e.g. Polyacrylates, polycarboxylates, Maleic acid / acrylic acid copoly
• the agent can contain up to 20% by weight, preferably 1 to 20% by weight.
• Prefers are polyhydric alcohols, especially propylene glycol, glycerin, sorbitol as well as mixtures of these alcohols.
• the agent according to the invention can contain up to 5% by weight of corrosion inhibitors, Preservatives, dyes and odor correctors included.
• the agent according to the invention can still contain up to 20% by weight, preferably 0.1 to 5 wt .-% of other nonionic surfactants that do not fall under the Formula II fall and which are selected from the group of alkyl alkoxylates, Alkylphenol alkoxylates, alkyl polyglucosides, alkyldimethylamine oxides, alkyl fatty acid amides and amide ether carboxylates, the terminal hydroxyl groups the alkyl alkoxylates and alkylphenol alkoxylates can also be etherified.
• the alkyl group has the usual range of 6 for such surfactants up to 18 carbon atoms.
• the agent according to the invention can additionally contain up to 20% by weight, preferably 0.01 to 7% by weight, of further anionic and / or amphoteric surfactants which are selected from the group consisting of alkyl sulfates, alkyl sulfonates, alkyl ether sulfates, alkyl C 6 -C 18 aryl sulfonates, alkylbetaines, alkyliminodipropionates, alkylamidopropylbetaines, the essential prerequisite being that the foam behavior of the agent according to the invention and of the application solution is not impaired by the additives.
• the alkyl group in each case has the range from 6 to 18, preferably 6 to 12, carbon atoms customary for such surfactants.
• the agent according to the invention up to 10 wt .-%, preferably up to 6% by weight of ethylene glycol monoalkyl ether, diethylene glycol monoalkyl ether, Propylene glycol monoalkyl ether, dipropylene glycol monoalkyl ether or their Add mixtures, the saturated linear or branched alkyl radical 1-6 Has carbon atoms.
• the pH of the agent is preferably between 4.0 and 13.0 between 4.0 and 9.0 and preferred in the case of an enzyme-containing version Values set between 4.0 and 8.5.
• the pH is regulated expediently with sodium hydroxide, potassium hydroxide and / or organic alkanolamines, e.g. Triethanolamine or triisopropanolamine or with the organic acids described above.
• the cleaning agent can be used as the concentrate or used as an aqueous or aqueous / alcoholic solution (application solution) become.
• An alcohol is preferred in the aqueous / alcoholic application solution used with two or three carbon atoms.
• the application solutions contain the cleaning agent (concentrate) in one Proportion from 0.1 to 10% by volume, preferably from 0.1 to 2% by volume.
• the cleaning agents and application solutions according to the invention can be used for Cleaning inanimate surfaces, especially medical ones Equipment, surgical instruments, anesthetic materials, rigid and flexible endoscopes are used. They are particularly suitable Cleaning agents according to the invention and application solutions for cleaning of surgical instruments, rigid and flexible endoscopes in cleaning and disinfection machines. After the cleaning process, a thermal or chemical-thermal disinfection with the usual for this Disinfectants can be used.
• the invention Cleaning agents and the application solutions can also be used without any problems Cleaning of other inanimate surfaces can be used, such as especially for cleaning bed frames, floors and inventory as well as for Bedpan cleaning.
• the surface tension was determined in a process known to the person skilled in the art using a commercially available tensiometer from Krüss determined a platinum-iridium ring, the sample vessel was thermostated.
• the foam values were determined in a swivel foam test. This was done in 50 ml of solution are placed in a 100 ml measuring cylinder, thermostated, 30 times Rotated 180 ° C and then immediately read the foam volume in ml.
• Recipe 1 was formulated without enzymes, while recipe 2 contains enzymes.
• Recipe component Recipe 1 Recipe 2 C 8 alkyl ether carboxylic acid 6 EO 4.0 3.5 TN55 ether surfactant 3.0 3.0 N-dodecylpyrrolidone 0.5 1.0 Citric acid 7 2nd Polyacrylate (e.g. Sokalan R types ex. BASF) 4th 10th Triethanolamine - 3rd Enzyme solution (e.g. Savinase R 16.0 L ex.Novo Northern Ireland) - 5 Propylene glycol - 20th Purified water ad 100 ad 100
• the pH of the formulations according to the invention was in each case with sodium hydroxide solution and citric acid set to 6.0.
• the recipes Preserved each with 0.1% methyl paraben to protect them against microbial To protect spoilage.
• the cleaning activity of the formulations according to the invention was determined using a plausible experimental model.
• stainless steel screws with coagulable Sheep blood contaminated dried at 30 ° C for 1 hour and then always 3 contaminated screws in one each with 200 ml of the concerned Beaker filled with 0.5% detergent solution.
• inventive Recipes through a constant low temperature independent Foam formation with a particularly low surface tension, a high cloud point and have a particularly good cleaning ability.
• good material compatibility with instrument steel, anodized aluminum, copper, brass and flexible materials such as Neoprene, soft PVC, polyethylene, rubber, silicone elastomers and latex determined.
• Tests for the mechanical processing of commercially available Gastroscopes in various cleaning and disinfection machines confirm the advantageous suitability of the agents according to the invention for the described application.

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• Chemical & Material Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Engineering & Computer Science (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Oil, Petroleum & Natural Gas (AREA)
• Wood Science & Technology (AREA)
• Organic Chemistry (AREA)
• Detergent Compositions (AREA)

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• 1998
  • 1998-10-15 DE DE19847498A patent/DE19847498C2/de not_active Expired - Fee Related
• 1999
  • 1999-10-12 ES ES99120336T patent/ES2192008T3/es not_active Expired - Lifetime
  • 1999-10-12 DE DE59904212T patent/DE59904212D1/de not_active Expired - Lifetime
  • 1999-10-12 EP EP99120336A patent/EP0994178B1/fr not_active Expired - Lifetime
  • 1999-10-12 AT AT99120336T patent/ATE232235T1/de active

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