EP0970742A2 - Dispositif d'agitation amélioré - Google Patents

Dispositif d'agitation amélioré Download PDF

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Publication number
EP0970742A2
EP0970742A2 EP99500114A EP99500114A EP0970742A2 EP 0970742 A2 EP0970742 A2 EP 0970742A2 EP 99500114 A EP99500114 A EP 99500114A EP 99500114 A EP99500114 A EP 99500114A EP 0970742 A2 EP0970742 A2 EP 0970742A2
Authority
EP
European Patent Office
Prior art keywords
magnet
magnetised
receptacle
rod
interior
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99500114A
Other languages
German (de)
English (en)
Other versions
EP0970742A3 (fr
Inventor
Adolfo Gallego Gutierrez
Steffen Schnabel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Life Science Technologies Ltd
Ral Tecnica para el Laboratorio SA
Original Assignee
Life Science Technologies Ltd
Ral Tecnica para el Laboratorio SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Life Science Technologies Ltd, Ral Tecnica para el Laboratorio SA filed Critical Life Science Technologies Ltd
Publication of EP0970742A2 publication Critical patent/EP0970742A2/fr
Publication of EP0970742A3 publication Critical patent/EP0970742A3/fr
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/452—Magnetic mixers; Mixers with magnetically driven stirrers using independent floating stirring elements

Definitions

  • the object of the present invention consists of a "IMPROVED AGITATOR DEVICE" of the type used in analysis laboratories for the measurement of times of formation of coagulation in studies of blood haemostasia.
  • an optical method is used, among others, consisting in the measurement of the intensity of light supplied by the liquid at a determined time.
  • the receptacles containing the liquid blood to be analysed are inserted into a spectrophotometric apparatus which measures the frequency of the radiation passing through the liquid, recording all the turbodensometric variations which are produced in the receptacle.
  • the spectrophotometric apparatus has available a constant source of light which passes through the sample to be analysed and falls on a detector placed opposite to it on the other side of the receptacle.
  • This detector presents various levels of detection, automatically preselected in the spectrophotometric apparatus before beginning the programmed measurement.
  • a magnetised agitator body has traditionally been employed, introduced into the interior of the receptacle and moved in a circular manner due to the magnetic force exerted by a magnet located in the body supporting the receptacle, which in its turn is turned in a circle on its own axis by means of a motor.
  • the said body generally presents an aerodynamic cylindrical form similar to a suppository, and its movement is horizontal over its centre of gravity, with the north and south poles at the ends turning, following the poles of the magnetised body in the interior of the support of the receptacle.
  • This type of agitation by means of the cylindrical body leaves areas in the upper part of the receptacle without being completely agitated, so that the spectrophotometric measurement is not at all accurate.
  • the improved agitator device consists of a thermostatic group with various positions, to maintain the receptacles and one or several measurement cells, guaranteeing a constant working temperature.
  • a magnetised agitator rod of a basically cylindrical form to homogenise the samples and reagents during the test.
  • This rod is activated by a magnet, located in the interior of the receptacle support, which presents a vertical orientation of the magnetic poles, due to which the agitator rod adopts a vertical position within the receptacle.
  • the magnet in the support acquires a circular movement through the action of the motor, the shaft of which holds the support which has the magnet in it on one side, moving in its turn the vertically positioned rod and thus producing the needed homogenisation.
  • the converter detector acts as a source of constant light passing through the sample to be analysed and falling on the converter detector which has several levels of detection automatically preselected by the system before beginning the programmed measurement, thus guaranteeing greater accuracy and assurance in the detection of coagulation.
  • the novel improved agitator device has an electronic system, controlled from a the central unit, which governs the whole process, from the voltage of the detector, the agitator motor, a digital chronometer, a screen, the keyboard, the block temperature and the whole system in general.
  • a vertical positioning of the agitator rod is achieved within the interior of the receptacle, which provides a perfect homogenisation in the interior of it for the determination of the times of formation of coagulation or other processes.
  • the novel "IMPROVED AGITATOR DEVICE” is constituted by a thermostatic group (1) with various positions to maintain the measurement receptacles (2) at a constant temperature, in which the reagents and the samples to be analysed are placed, and which incorporate within the interior a magnetised agitator rod (3) of a basically cylindrical form.
  • the rod (3) is activated by a magnet (4) from a spectrophotometer, which is located in one side of the interior of the support (10) where the receptacle (2) is placed.
  • This magnet (4) presents a vertical orientation of the magnetic poles.
  • the magnet (4) of the support acquires a circular movement through the action of the support (10), driven by a motor (5) on the shaft (6) of which it is fixed, due to which the vertically positioned rod is moved.
  • the novel device has also an optical system comprising an excitation source (7), and a light/frequency detector converter (8) which records all the turbodensometric variations occurring in the receptacle.
  • the light from the constant excitation source (7) passes through the sample to be analysed and falls on the detector converter (8) which has various levels of detection automatically preselected by the system before beginning the programmed measurement.
  • the novel improved agitator device has an electronic system, controlled from the central unit (9), which governs the whole process, from the voltage of the detector (8), the agitator motor (5), a digital chronometer, a screen (13), the keyboard (14), the block temperature (1), an RS 232 output (11), printer (12) and the whole system in general.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP99500114A 1998-07-09 1999-07-06 Dispositif d'agitation amélioré Withdrawn EP0970742A3 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES9801833 1998-07-09
ES9801833 1998-07-09

Publications (2)

Publication Number Publication Date
EP0970742A2 true EP0970742A2 (fr) 2000-01-12
EP0970742A3 EP0970742A3 (fr) 2002-01-23

Family

ID=8305020

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99500114A Withdrawn EP0970742A3 (fr) 1998-07-09 1999-07-06 Dispositif d'agitation amélioré

Country Status (1)

Country Link
EP (1) EP0970742A3 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7718072B2 (en) 2002-04-26 2010-05-18 Abbott Laboratories Structure and method for handling magnetic particles in biological assays

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1235589A (en) * 1968-06-17 1971-06-16 Baxter Laboratories Inc Improvements relating to sensing when viscosity of a fluid has risen to a given level
GB2082930A (en) * 1980-08-27 1982-03-17 Thomas Thomas Ronald Magnetic stirring element
JPS60156538A (ja) * 1984-01-27 1985-08-16 Imamura Seisakusho:Kk 液体または粉体の撹拌，混合及び混練装置
US4876069A (en) * 1981-07-11 1989-10-24 Siegfried Jochimsen Blood clotting time measuring apparatus
US4964728A (en) * 1977-03-11 1990-10-23 Firma Labor Laborgerate'Analysensysteme Vertriebsgesellschaft mbH Blood coagulation time measuring device

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1235589A (en) * 1968-06-17 1971-06-16 Baxter Laboratories Inc Improvements relating to sensing when viscosity of a fluid has risen to a given level
US4964728A (en) * 1977-03-11 1990-10-23 Firma Labor Laborgerate'Analysensysteme Vertriebsgesellschaft mbH Blood coagulation time measuring device
GB2082930A (en) * 1980-08-27 1982-03-17 Thomas Thomas Ronald Magnetic stirring element
US4876069A (en) * 1981-07-11 1989-10-24 Siegfried Jochimsen Blood clotting time measuring apparatus
JPS60156538A (ja) * 1984-01-27 1985-08-16 Imamura Seisakusho:Kk 液体または粉体の撹拌，混合及び混練装置

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7718072B2 (en) 2002-04-26 2010-05-18 Abbott Laboratories Structure and method for handling magnetic particles in biological assays
US8211301B2 (en) 2002-04-26 2012-07-03 Abbott Laboratories Structure and method for handling magnetic particles in biological assays
US8728311B2 (en) 2002-04-26 2014-05-20 Abbott Laboratory Structure and method for handling magnetic particles in biological assays

Also Published As

Publication number Publication date
EP0970742A3 (fr) 2002-01-23

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