EP0927019A1 - Compositions for cosmetic applications - Google Patents

Compositions for cosmetic applications

Info

Publication number
EP0927019A1
EP0927019A1 EP98918925A EP98918925A EP0927019A1 EP 0927019 A1 EP0927019 A1 EP 0927019A1 EP 98918925 A EP98918925 A EP 98918925A EP 98918925 A EP98918925 A EP 98918925A EP 0927019 A1 EP0927019 A1 EP 0927019A1
Authority
EP
European Patent Office
Prior art keywords
extract
peg
cosmetic composition
oil
polymer network
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98918925A
Other languages
German (de)
French (fr)
Inventor
Eyal S. Ron
Barry J. Hand
Lev S. Bromberg
Marie Kearney
Matthew E. Schiller
Peter M. Ahearn
Scott Luczak
Thomas H. E. Mendum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medlogic Global Corp
Original Assignee
Medlogic Global Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medlogic Global Corp filed Critical Medlogic Global Corp
Publication of EP0927019A1 publication Critical patent/EP0927019A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0212—Face masks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/90—Block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/04—Preparations for care of the skin for chemically tanning the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/04—Preparations for permanent waving or straightening the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q9/00—Preparations for removing hair or for aiding hair removal
    • A61Q9/02—Shaving preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/54—Polymers characterized by specific structures/properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

Definitions

  • the present invention relates to a cosmetic composition useful in a variety of topical and personal care products, including treatments of disorders and imperfections of the skin or o ⁇ er areas of the body. More particularly, the present invention is directed to a cosmetic composition comprising a poloxamer:poly(acrylic acid) polymer network that can be designed to reversibly gel over a wide range of conditions to provide a composition having a controllable range of viscosities, making it useful in a variety of cosmetic and personal care applications.
  • hydrogels such as cellulosics
  • a hydrogel is a polymer network which absorbs a large quantity of water without the polymer dissolving in water.
  • the hydrophilic areas of the polymer chain absorb water and form a gel region.
  • the extent of gelation depends upon the volume of the solution which the gel region occupies.
  • Reversibly gelling solutions are known in which the solution viscosity increases and decreases with an increase and decrease in temperature, respectively. Such reversibly gelling systems are useful wherever it is desirable to handle a material in a fluid state, but performance is preferably in a gelled or more viscous state.
  • a known material with these properties is a thermal setting gel using block copolymer polyols, available commercially as Pluronic® polyols (BASF,
  • Another known system which is liquid at room temperature, but forms a semi- solid when warmed to about body temperature is formed from tetrafunctional block polymers of polyoxyethylene and polyoxypropylene condensed with ethylenediamine. commercially available as Tetronic® polyols. These compositions are formed from approximately 10% to 50% by weight of the polyol in an aqueous medium. See, U.S. Patent No. 5,252.318.
  • compositions including Pluronic® and Tetronic® polyols commercially available forms of poly(ethylene glycol)/poly(propylene glycol) block copolymers, significant increases in viscosity (5- to 8-fold) upon a simultaneous change in temperature and pH are observed only at much higher polymer levels. See, Figs. 3-6 of Joshi et al.
  • WO 95/24430 disclose block and graft copolymers comprising a pH-sensitive polymer component and a temperature-sensitive polymer component.
  • the block and graft copolymers are well-ordered and contain regularly repeating units of the pH-sensitive and temperature-sensitive polymer components.
  • the copolymers are described as having a lower critical solution temperature (LCST), at which both solution-to-gel transition and precipitation phase transition occur.
  • LCST critical solution temperature
  • Light transmission is reduced, which may be undesirable in many applications, where the aesthetic characteristics of the composition are of some concern.
  • the known systems which exhibit reversible gelation art limited in that they require large solids content and/or in that the increase in viscosity less than 10- fold.
  • a cosmetic composition which incorporates a poloxamer:poly(acrylic acid) polymer network as a cosmetically acceptable carrier.
  • the polymer network comprises a poloxamer component randomly bonded to a poly(acrylic acid), or PAA. component in an aqueous-based medium, the polymer network being capable of aggregating in response to an increase in temperature.
  • the reverse thermal viscosifying poloxamer:poly(acrylic acid) polymer network includes random covalent bonding between the poly(acrylic acid) component and the poloxamer component of the network.
  • the polymer network may also include some unbound or "free" poloxamer or other additives which contribute to or modify the characteristic properties of the polymer composition.
  • the cosmetic composition includes a cosmetic agent selected to provide a preselected cosmetic effect.
  • cosmetic agent as that term is used herein, it is meant that the additive imparts a cosmetic effect.
  • a cosmetic effect is distinguishable from a pharmaceutical effect in that a cosmetic effect relates to the promoting bodily attractiveness or masking the physical manifestations of a disorder or disease.
  • a pharmaceutic seeks to treat the source or symptom of a disease or physical disorder. It is noted however, that the same additives may have either a cosmetic or pharmaceutical effect, depending upon the amounts used and die manner of administration.
  • Cosmetic as that term is used herein, it is meant the cosmetic and personal-care applications intended to promote bodily attractiveness or to cover or mask the physical manifestations of a disorder or disease.
  • Cosmetics include those products subject to regulation under the FDA cosmetic guidelines, as well as sunscreen products, acne products, skin protectant products, anti-dandruff products, and deodorant and antiperspirant products.
  • gelation or viscosification, as that term is used herein, it is meant a drastic increase in the viscosity of the polymer network solution. Gelation is dependent on the initial viscosity of the solution, but typically a viscosity increase in the range of preferably 2- to 100-fold, and preferably 5- to 50-fold, and more preferably 10- to 20- fold is observed in the polymer network which is used in d e preparation of the cosmetic compositions of the invention. Such effects are observed in a simple polymer network solution and the effect may De modified by the presence of other components in the cosmetic composition.
  • polystyrene resin is a triblock copolymer derived from poIy(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol) blocks.
  • the poloxamer is capable of responding to a change in temperature by altering its degree of association and/or agglomeration.
  • the aggregation may be in the form of micelle formation, precipitation, labile crosslinking or other factors.
  • the poly(acrylic acid) component includes poly(acrylic acid) and its salts.
  • the poly(acrylic acid) supports and interacts with the poloxamer component so that a multi-material, responsive polymer network is formed.
  • the interaction of the poloxamer and poly(acrylic acid) exhibits a synergistic effect, which magnifies the effect of the poloxamer component in viscosifying and/or gelling the solution.
  • the novel interaction between the constituent polymers components of the polymer network permits formation of gels at very low solids content. Gelation and/or viscosification is observed in aqueous solutions having about 0.01 to 20 wt% of the poloxamer component and about 0.01 to 20 wt% of the poly(acrylic acid) component.
  • a typical reversibly gelling polymer network may be comprised of less than about 4 wt% of total polymer solids (e.g., poloxamer and poly(acrylic acid))and even less dian lwt% total polymer solids while still exhibiting reverse thermal viscosification.
  • total polymer solids e.g., poloxamer and poly(acrylic acid)
  • d e total solids content including additives of a reversibly gelling polymer network composition may be much higher.
  • the viscosity of the gel increases at least ten-fold with an increase in temperature of about 5°C at pH 7 and 1 wt% polymer. Viscosity increases may be even greater over a larger temperature range at pH 7 and 1% polymer network content.
  • the relative proportion of poloxamer and poly(acrylic acid) may vary dependent upon the desired properties of the polymer composition.
  • the poloxamer is present in a range of about 1 to 20 wt% and the poly(acrylic acid) is present in a range about of 99 to 80 wt%.
  • the poloxamer component is present in a range of about 21 to 40 wt% and the poly(acrylic acid) component is present in a range of about 79 to 60 wt%.
  • the poloxamer component is present in a range of about 41 to 50 wt% and the poly(acrylic acid) component is present in a range of about 59 to 50 wt%.
  • the poloxamer component is present in a range of about 51 to 60 wt% and the poly(acrylic acid) component is present in a range of about 49 to 40 wt%.
  • me poloxamer component is present in a range of about 61 to 90 wt% and the poly(acrylic acid) component is present in a range of about 39 to 20 wt%.
  • d e poloxamer component is present in a range of about 81 to 99 wt% and me poly(acrylic acid) component is present in a range of about 19 to 1 w ⁇ %.
  • the poloxame ⁇ poly(acrylic acid) polymer network described above is included in a cosmetic composition to improve the flow characteristics, thickness and other properties of the composition.
  • the composition includes additional cosmetic agents. such as are needed for the cosmetic purpose of the composition.
  • Additives also may be included to modify die polymer network performance, such as to increase or decrease the temperature of the liquid-to-gel transition and/or to increase or decrease the viscosity of the responsive polymer composition.
  • the poloxamer:poly(acrylic acid) polymer network is incorporated into a cosmetic compositions to impart thickening properties to the cosmetic composition at the use and/or application temperature. Such thickening properties include enhanced overall viscosity, as well as a desirable viscosity response with temperature.
  • the polymer network may be useful as a diickener in pH ranges where other thickeners are not effective.
  • the poloxamer:poly(acrylic acid) polymer network is incorporated into a cosmetic composition to stabilize and solubilize hydrophobic agents in the cosmetic composition.
  • the polymer network may be included to increase emulsion stability. Many emulsions, i.e.. suspension of small droplets or particles of a first material in a second material, lose viscosity upon heating. As will be demonstrated herein, the poloxamer:poly(acrylic acid) polymer network retains its emulsifying properties even with temperature increase.
  • composition may be included in the composition to impart emolliency to the composition.
  • the composition may also act as a film-forming agent after it has been applied to die skin. This film-forming agent may be used as a barrier to prevent water loss from the skin which contributes to the moisturization of the skin.
  • the poloxamer:poly(acrylic acid) poiymer network may be included as an additive in cosmetic applications to prevent viscosity loss at elevated temperatures.
  • Figure 1 is a graph of viscosity vs. temperature for a 1 wt%, 2 wt% and 3 wt% responsive polymer network aqueous composition of a poloxamer/poly(acrylic acid) (1 : 1) at pH 7.0 measured at a shear rate of 0.44 sec "1 ;
  • Figure 2 is a graph of viscosity vs. temperature for a 1 wt% poloxamer: poly(acrylic acid) polymer network composition demonstrating reversibility of the viscosity response;
  • Figure 3 shows die viscosity response of a 2 wt% poloxamer:poly(acrylic acid) polymer composition at various shear rates;
  • Figure 4 shows a viscosity response curve for a 2 wt% poloxamer: poly(acrylic acid) polymer network composition prepared wim nominal mixing and stirring and prepared using high shear homogenization (8000 rpm, 30 min);
  • Figure 5 is a graph of viscosity vs. temperature for a 1 wt% poloxamer: poly(acrylic acid) polymer network composition at various pHs;
  • Figure 6 is a graph of viscosity vs. temperature for a 1 wt% poloxamer: poly(acrylic acid) polymer network composition with and without addition ol 0.25 wt% KC1;
  • Figure 7 is a graph of viscosity vs. temperature for a 1 wt% poloxamer: poly(acrylic acid) polymer network composition with and without addition of 0.5 wt% acetamide MEA;
  • Figure 8 is a graph of viscosity vs. temperature for a 1 wt% poloxamer: poly(acrylic acid) polymer network composition wi out and with 5 wt%, 10 wt% and 20 wt% added ethanol, respectively;
  • Figure 9 is an illustration of a reversibly gelling polymer network used as an emuisifier and stabilizer for a hydrophobic agent
  • Figure 10 is a schematic illustration of me poloxamer:poly(acrylic acid) polymer network below and above the transition temperature illustrating die aggregation of the hydrophobic poloxamer regions;
  • Figure 1 1 is a graph of viscosity vs. pH for a 1 wt% responsive polymer network aqueous composition of a poloxamer/poly(acrylic acid) (1 :1) measured at a shear rate of 0.44 sec "1 ;
  • Figure 12 is a plot of viscosity vs. temperature for (a) a 1 wt% responsive polymer network aqueous composition of Pluronic® F127 poloxamer/poly(acrylic acid) (1 : 1) and (b) a 1 wt% physical blend of Pluronic® F127 poloxamer/poly(acrylic acid) (1 : 1) at pH 7.0 measured at a shear rate 0.22 sec "1 ;
  • Figure 13 is a plot of viscosity vs. temperature for a 1 wt% responsive polymer network aqueous composition of Pluronic® F88 poloxamer/poly(acrylic acid) (1 : 1) at pH 7.0 measured at a shear rate 2.64 sec " ';
  • Figure 14 is a graph of the viscosity vs. temperature effect for a responsive polymer network composition of 2 wt% Pluronic® PI 04 poloxamer/poly(acrylic acid) (1 : 1) in deionized water at pH 7.0 measured at shear rate of 22 sec "1 ;
  • Figure 15 is plot of viscosity vs. temperature for a responsive polymer network composition of 2 w ⁇ % Pluronic® F123 poloxamer/poly(acrylic acid) (1 : 1) at pH 7.0 measured at a shear rate of 22 sec " ':
  • Figure 16 is a plot of viscosity vs. temperature for 1 wt% made of series of poloxamers and poly(acrylic acid) (1 : 1) in deionized water at a shear rate of 132 sec '1 ;
  • Figure 17 is a plot showing release of hemoglobin from a poloxamer/poly(acrylic acid) polymer network of the invention.
  • Figure 18 is a plot showing the release of lysozyme from the poloxamer/poly(acrylic acid) polymer complex of the invention:
  • Figure 19 is a plot showing release of insulin from a poloxamer/poly(acrylic acid) polymer network composition of the invention:
  • Figure 20 is a plot of viscosity vs. temperature for a poloxamer/poly(acrylic acid) polymer network composition (a) before and (b) after sterilization by autoclave;
  • Figure 21 is a plot of viscosity vs. temperature for an oil-free moisturizing formulation prepared from (a) a responsive polymer network composition of the invention and (b) a conventional oil-in-water formulation;
  • Figure 22 is a plot of equilibrium solubility of estradiol (A, B) and progesterone (C, D) in aqueous solutions (pH 7) of Pluronic® F127 (A, C) and responsive polymer network (B, D) vs. temperature;
  • Figure 23 is a plot of the ratio of equilibrium solubilities of estradiol in responsive polymer network and water vs. polymer concentration in the responsive polymer network solutions;
  • Figure 24 is a plot of the effect of loading fluorescein on the onset of gelation of responsive polymer network vs. total polymer concentration in responsive polymer network solution (pH 7.0);
  • Figure 25 is a plot of die percentage of a) estradiol and b) progesterone release from responsive polymer network vs. time;
  • Figure 26 is a plot of the rate of progesterone release and macroscopic viscosity vs. polymer concentration
  • Figure 27 is a plot of the percentage of progesterone release vs. polymer concentration in responsive polymer network and, Figure 28 is a plot of the relative diffusivity of poly(styrene) latex panicles in water and responsive polymer network.
  • the present invention is directed to a cosmetic composition
  • a cosmetic composition comprising a cosmetically acceptable carrier comprising a novel poloxamer:poly acrylic acid) polymer network.
  • the polymer network functions as a temperature sensitive thickening agent, and in addition possesses surfactant and emulsifying capabilities which may be beneficial to the cosmetic composition.
  • the polymer network composition according to the invention includes a poloxamer component randomly bonded to a poly(acrylic acid) component. The two polymer components may interact with one another on a molecular level.
  • the polymer network contains about 0.01-20 wt% each of poloxamer and poly(acrylic acid).
  • Exemplary polymer network- compositions range from about 1 : 10 to about 10:1 poloxamer:poly(acrylic acid).
  • Polymer network gel compositions which exhibit a reversible gelation at body temperature (25-40°C) and or at physiological pH (ca. pH 3.0-9 0) and even in basic environments up to pH 13 (hair care) are particularly
  • a 1 : 1 poloxamer:poly(acrylic acid) polymer network at appropriate pH exhibits flow properties of a liquid at about room temperature, yet rapidly thickens into a gel consistency of at least about five times greater, preferably at least about 10 times greater, and even more preferably at least about 30 times and up to 100 times greater, viscosity upon increase in temperature of about 10 °C and preferably about 5 °C.
  • the reversibly gelling polymer network of the present invention exhibit gelation even at very low polymer concentrations.
  • polymer network compositions at pH 7 comprising about 0.5 wt% poloxamer component and about 0.5 wt% PAA exhibits a significant increase in viscosity from a free-flowing liquid (50 cps) to a gel (6000 cps).
  • the observed gelation takes place at low solids contents, such as less tiian 20 wt% or preferably less than about 10 wt%, or more preferably less than about 2.5 wt% or most preferably less than about 0.1 wt%.
  • only a small amount by weight of the polymer network need be incorporated into a cosmetic composition in order to provide me desired thickening or viscosifying effect.
  • the reverse viscosification effect at low polymer concentrations provides clear, colorless gels which are particularly well-suited to cosmetic applications. For example, very little residue is formed upon dehydration which may be important in some applications, such as in topically applied cosmetics.
  • An additional advantage of d e polymer network of the invention is that it remains clear and translucent above and below the critical temperature or pH. These characteristics of me reversibly gelling polymer network make it well suited for use in cosmetic compositions.
  • the polymer network of the present invention technology may be added to cosmetic formulations to increase the diickness and viscosity of die composition.
  • the poloxamer:poly(acrylic acid) polymer network possesses hydrophobic regions capable of aggregation.
  • the aggregation of the polymer network of the present invention is temperature sensitive.
  • die inventive polymer network of the present invention may have a transition temperature (i.e. temperature of aggregation) above room temperature so that die cosmetic composition is of low viscosity at or below room temperature and is of high viscosity at or around body temperature (body temperature includes both surface and internal body temperature).
  • body temperature includes both surface and internal body temperature.
  • a composition may be prepared at low temperatures while the polymer network is in a low viscosity state. Mixing of ingredients under low viscosity is expected to be easier, thus simplifying the manufacturing process. Yet, the resultant mixture would be of increased viscosity at use temperatures.
  • a cosmetic composition comprising poloxamer:poly(acrylic acid) polymer network may be spread ti inly to allow for even application, due to its low viscosity at room temperature, but will thicken and "fill" the skin contours upon warming up to body surface temperature.
  • d e composition may be applied d rough a nozzle d at provides high shear to reduce viscosity, yet the composition regains its viscosity after application to d e skin. This contrasts with conventional formulations which permanently lose viscosity after being subjected to high shear.
  • the composition may be formulated and applied as a liquid, spray, semi-solid gel, cream, ointment, lotion, stick, roll-on formulation, mousse, pad-applied formulation, and film-forming formulation.
  • the poloxamer:poly(acrylic acid) polymer network may also be included in a cosmetic composition for use as a stabilizing, solubilizing or emulsifying agent for a hydrophobic component of the cosmetic formulation.
  • the strong hydrophilic regions of the poloxamer resulting from aggregation and micelle formation create hydrophobic domains which may be used to solubilize and control release of hydrophobic agents. Similar micelle-based systems have been shown to protect trapped peptides against enzymatic degradation from surface enzymes.
  • the reversibly gelling polymer network of the present invention is a unique polymer composition designed to abruptly change its physical characteristics or the characteristics and properties of materials mixed d erewith with a change in temperature.
  • d e structure of the polymer network involves a random bonding of die poloxamer onto the backbone of die poly(acrylic acid).
  • a portion of the poloxamer which is present during d e polymerization reaction which forms the poly(acrylic acid) is bonded to the backbone of the forming poly(acrylic acid) dirough hydrogen abstraction and subsequent reaction. See detailed discussion of die mechanism, below.
  • the combination of the poly(acrylic acid) and randomly bonded poloxamer gives the composition its unique properties. Any free poloxamer remaining after polymerization of PAA remains associated with the random co-polymer, resulting in a miscible composition.
  • Free poloxamer may also be present in the polymer network composition; however, its presence is not required in order to observe reverse thermal viscosification.
  • the poly(acrylic acid) may be linear, branched and/or crosslinked. Poly(acrylic acid) is capable of ionization with a change in pH of the solution. By ionization, as tiiat term is used witii respect to poly(acrylic acid), it is meant the formation of d e conjugate base of the acrylic acid, namely acrylate.
  • poly(acrylic acid) includes both ionized and non-ionized versions of me polymer. Changes in ionic strength may be accomplished by a change in pH or by a change in salt concentration.
  • the viscosifying effect of the polymer network is partly a function of the ionization of d e poly(acrylic acid); however, reverse thermal gelling may occur without ionization. Changes to the ionic state of the polymer causes the polymer to experience attractive (collapsing) or repulsive (expanding) forces. Where there is no need or desire for the composition to be applied in a high viscosity state, it may be possible to prepare the composition as non-ionized poly(acrylic acid). The body ' s natural buffering ability will adjust the pH of the applied composition to ionize the poly(acrylic acid) and diereby develop its characteristic viscosity.
  • the poloxamer possesses regions of hydrophobic character, e.g., polypropylene glycol) blocks, and hydrophilic character, e.g.. poiy(ethylene glycol) blocks.
  • the poloxamer may be linear or branched.
  • Suitable poloxamers include triad block copolymers of poly(ethylene glycol) and poly(propylene glycol) having the general formula (P
  • poly(propylene glycol) represents the hydrophobic portion of the polymer and poly(etirylene glycol) represents the hydrophilic portion of die polymer.
  • Pluronic® polymers BASF are commercially available for a in the range of 16 to 48 and b ranging from 54-62.
  • One or more poloxamers may be used in die reversibly gelling polymer network composition of the present invention.
  • the reversibly gelling responsive polymer networks compositions of me present invention are highly stable and do not exhibit any phase separation upon standing or upon repeated cycling between a liquid and a gel state. Samples have stood at room temperature for more than three months without any noticeable decomposition, clouding, phase separation or degradation of gelation properties. This is in direct contrast to polymer blends and aqueous mixed polymer solutions, where phase stability and phase separation is a problem, particularly where the constituent polymers are immiscible in one anotiier.
  • Figure 1 is a graph of viscosity vs. temperature for 1 wt%, 2 wt% and 3 wt% polymer network compositions comprising 1 : 1 poloxamer:poly(acrylic acid), hydrated and neutralized.
  • the viscosity measurements were taken on a Bro ⁇ kfield viscometer at a shear rate of 0.44 sec " ' at pH 7.0. All solutions had an initial viscosity of about 1080 cP and exhibited a dramatic increase in viscosity to gel point at about 35°C.
  • poloxamer:poly(acrylic acid) polymer network composition does not permanently loose viscosity after being subjected to high shear conditions.
  • the poloxamer:poly(acrylic acid) polymer network composition remains unaffected by such shear conditions as homogenization.
  • Figure 4 compares die viscosity response curve of a 2 wt% poloxamer:poly(acrylic acid) polymer composition prepared with nominal mixing (simple lime) and stirring with that of a polymer composition of similar composition prepared using high shear homogenization designated by a ticked line (8000 rpm, 30 min). No significant decrease in viscosity is observed.
  • the responsive polymer network may also include additives for influencing die performance of the polymer composition, such as the transition temperature and the viscosity of the polymer composition above me transition temperature.
  • additives for influencing die performance of the polymer composition such as the transition temperature and the viscosity of the polymer composition above me transition temperature.
  • the following list is not intended to be exhaustive but rather illustrative of the broad variety of additives which can be used.
  • solvents e.g., 2-propanol, ethanol, acetone, 1,2- pyrrolidinone, N-methylpyrrolidinone
  • salts e.g., calcium chloride, sodium chloride, potassium chloride, sodium or potassium phosphates, borate buffers, sodium citrate
  • preservatives benzalkonium chloride, phenoxyethanol, sodium hydroxymediylglycinate.
  • ethylparaben benzoyl alcohol, methylparaben, propylparaben.
  • humectant/moisturizers acetamide MEA, lactimide MEA, hydrolyzed collagen, mannitol, pandienol, glycerin
  • lubricants hyaluronic acid, mineral oil, PEG-60-lanolin, PPG-12-PEG-50-lanolin, PPG-2 myristyl ether propionate
  • surfactants may be divided into tiiree classes: cationic, anionic, and nonionics.
  • An example of a cationic surfactant used is ricinoleamidopropyl ethyldimonium ed osulfate (Lipoquat R).
  • Anionic surfactants include sodium dodecyl sulfate and etiier sulfates such as Rhodapex CO-436.
  • Nonionic surfactants include Surfynol CT-111, TG, polyoxyediylene sorbitan fatty acid esters such as Tween 65 and 80, sorbitan fatty acid esters such as Span 65, alkylphenol ethoxylates such as Igepal CO-210 and 430, dimethicone copolyols such as Dow Corning 190, 193, and Silwet L7001.
  • polymers including xanthan gum.
  • cellulosics such as hydroxyethylcellulose (HEC), carbomethoxycellulose (CMC), lauryldimonium hydroxypropyl oxyethyl cellulose (Crodacel QL). hydroxypropylcellul.se (HPC), and hydroxypropylmethylcellulose (HPMC).
  • HEC hydroxyethylcellulose
  • CMC carbomethoxycellulose
  • HPC hydroxypropylcellul.se
  • HPMC hydroxypropylmethylcellulose
  • Poloxamers may also be used as additives.
  • Examples include bodi the Pluronic® polyols having an (P 1 ) a (P : ) b (P ⁇ ) a structure such as Pluronic® F38. L44. P65, F68. F88. L92, P103. P104. P105. F108. L 122 and F127, as well as the reverse
  • Pluronic® R series (P : ) a (P,) b (Pi) a structure such as Pluronic® 17R2 and 25R8.
  • Other miscellaneous materials include propylene glycol. urea, triethanolamine. alkylphenol etiioxylates (Iconol series), and linear alcohol alkoxylates (Plurafac series).
  • Additives affect the viscosity of the compositions differently depending upon the nature of the additive and its concentration. Some additives will affect the initial or final viscosity, whereas others will affect d e temperature range of the viscosity response, or both.
  • Potassium chloride and acetamide MEA are two examples of additives which decrease the final viscosity of the composition (see, Example 30).
  • KC1 (0.25%) added to a 1 wt% reversibly gelling polymer composition reduces the viscosity by about 3000 cps. See, Figure 6.
  • the humectant, acetamide MEA lowers the viscosity of a 1 wt% solution by approximately 1,500 cps (see, Figure 7).
  • Glycerin, etiianol and dimetiiicone copolymer have been shown to affect d e temperature range over which the viscosity response occurs. Glycerin shifts the transition temperature to a slightly lower range from an initial 24-34 °C to about 24- 30 °C, but does not affect die final viscosity (see, Example 44). The effect of ethanol on d e viscosity is different at different concentration levels. At 5 wt% and 10 wt% added ethanol, die transition temperature is shifted to lower ranges, e.g., 24-29 °C and 20-29 ° C. respectively. At 20 wt% added ethanol.
  • d e composition not only exhibits a lowering of the transition temperature, but also a marked increase in initial and final viscosity. See, Figure 8. Dimethicone copolymer ( 1 wt%) also changed the transition temperature, but in this instance the transition temperature range was raised to 28- 41 ° C. Thus, proper selection of additives permits me formulator to adjust d e transition temperature to various ranges.
  • the polymer network compositions of the present invention may be utilized for a wide variety of cosmetic and personal care applications. To prepare a cosmetic composition, an effective amount of cosmetically active agent(s) which imparts the desirable cosmetic effect is incorporated into the reversibly gelling polymer network composition of the present invention.
  • the selected agent is water soluble, which will readily lend itself to a homogeneous dispersion through out the reversibly gelling polymer network composition; however, the polymer network has been demonstrated to significantly solubilize or suspend hydrophilic agents in order to improve formulation homogeneity (see. Example 36). It is also preferred that the agent(s) is nonreactive with the polymer network composition. For materials which are not water soluble, it is also within die scope of the invention to disperse or suspend powders or oil (lipophilic materials) throughout the polymer network composition. It will also be appreciated tiiat some applications may require a sterile environment.
  • the reversibly gelling polymer network compositions of the present invention may be prepared under sterile conditions.
  • An additional feature of the reversibly gelling polymer composition is mat is prepared from constituent polymers that have known accepted toxicological profiles.
  • the poloxamer:poly(acrylic acid) polymer network has been evaluated under Good Laboratory Practice (GLP) standard protocols known in the art for toxicity in animal models and found to exhibit no toxic effects. The results of the toxicity study are summarized in the following Table 1. The non-toxicity of the polymer network makes it an ideal candidate for use in cosmetic compositions. Table 1. Toxicity data for 6% poloxamer: poly(acry lie acid) solution at pH 7.
  • Exemplary cosmetic and personal care applications for which the reversibly gelling polymer network composition may be used include, but are not limited to, baby products, such as baby shampoos, lotions, powders and creams: bath preparations, such as bath oils, tablet and salts, bubble baths, bath fragrances and bath capsules; -eye makeup preparations, such as eyebrow pencil, eyeliner, eye shadow, eye lotion, eye makeup remover and mascara; fragrance preparations, such as colognes and toilet waters, powders and sachets; noncoloring hair preparations, such as hair conditioner, hair spray, hair straighteners, permanent waves, rinses shampoos, tonics, dressings and otiier grooming aids; color cosmetics; hair coloring preparations such as hair dye, hair tints, hair shampoos, hair color sprays, hair lighteners and hair bleaches; makeup preparations such as face powders, foundations, leg and body paints, lipstick, makeup bases, rouges and makeup fixatives; manicuring preparations such as basecoats and undercoats,
  • the cosmetic composition may be in any form. Suitable forms include but are not limited to lotions, creams, sticks, r ⁇ ll-ons formulations, mousses, aerosol sprays, pad-applied formulations, and film-forming formulations.
  • the foregoing list is exemplary only. Because the reversibly gelling polymer network composition of die present invention is suited for application under a variety of physiological conditions, a wide variety of cosmetically active agents may be incorporated into and administered from the polymer network composition.
  • additional cosmetically acceptable carriers may be included in die composition, such as by way of example only, emollients, surfactants, humectants, powders and other solvents.
  • the cosmetic composition also may include additional components, which serve to provide additional aspects of the cosmetic affect or to improve the stability and/or administration of the cosmetic.
  • Such additional components include, but are not limited to, preservatives, abrasives, acidulents, antiacne agents, anti-aging agents, antibacterials, anticaking, anticaries agents, anticellulites, antidandruff, antifungal, anti-inflammatories, anti-irritants, antimicrobials, antioxidants, astringents, anitperspirants, antiseptics, antistatic agents, astringents, binders, buffers, additional carriers, chelators, cell stimulants, cleansing agents, conditioners, deodorants, dipilatories, detergents, dispersants, emollients, emulsifiers, enzymes, essential oils, exfoliants, fibers, film forming agents, fixatives, foaming agents, foam stabilizers, foam boosters, fungicides, gellants, glosser.
  • preservatives include, but are not limited to, preservatives, abrasives, acidulents, antiacne agents, anti-aging
  • hair conditioner hair set resins, hair sheen agents, hair waving agents, humectants.
  • lubricants moisture barrier agents, moisturizers, ointment bases, opacifier. plasticizer. polish, polymers, powders, propellant, protein, refatting agents, sequestrant, silicones.
  • Suitable materials which serve the additive functions listed here are well known in the cosmetic industry.
  • compositions of the invention include a safe and effective amount of a cosmetically active agent.
  • Safe and effective means an amount high enough to significantly positively modify the condition to be treated or the cosmetic effect to be obtained, but low enough to avoid serious side effects.
  • Preservatives can be desirably incorporated into the cosmetic compositions of die invention to protect against the growth of potentially harmful microorganisms.
  • Suitable preservatives include, but are not limited to, alkyl esters of para- hydroxybenzoic acid, hydantoin derivatives, parabens, propioniate salts, triclosan tricarbanilide, tea tree oil, alcohols, farnesol, farnesol acetate, hexachlorophene and quaternary ammonium salts, such as benzoiconjure, and a variety of zinc and aluminum salts.
  • Cosmetic chemists are familiar with appropriate preservatives and may selects that which provides die required product stability. Preservatives are preferably employed in amounts ranging from about 0.0001% to 2% by weight of the composition.
  • Emollients can be desirably incorporated into the cosmetic compositions of die invention to provide lubricity to the formulation.
  • Suitable emollients may be in the form of volatile and nonvolatile silicone oil. highly branched hydrocarbons and synti etic esters. Amounts of emollients may be in the range of about 0.1-30 wt%, and preferably about 1-20 wt%.
  • suitable silicones include cyclic or linear pol dimethylsiloxanes, polyalkylsiloxanes, polyalkylarylsiloxanes and polyether siloxanes.
  • ester emollients include alkenyl esters of fatty acids, polyhydric alcohols, such as ethylene glycol mono and di-fatty acid esters, polyethylene glycol and the like, ether-esters, such as fatty acid esters of ethoxylated fatty alcohols, wax esters, such as beeswax, spermaceti, mysristyl myristate and stearyl stearate. and sterol esters, such as cholesterol fatty acids.
  • ether-esters such as fatty acid esters of ethoxylated fatty alcohols
  • wax esters such as beeswax, spermaceti, mysristyl myristate and stearyl stearate.
  • sterol esters such as cholesterol fatty acids.
  • a variety of oily emollients may be employed in the compositions of this invention. These emollients may be selected from one or more of the following classes: 1.
  • Triglyceride esters such as vegetable and animal fats and oils. Examples include castor oil. cocoa butter, safflower oil, cottonseed oil. corn oil, olive oil, cod liver oil, almond oil, avocado oil, palm oil, sesame oil, squalene. Kikui oil and soybean oil; 2. Acetoglyceride esters, such as acetylated monoglycerides; 3.
  • Ethoxylated glycerides such as ethoxylated glyceryl monostearate: 4.
  • Alkyl esters of fatty acids having 10 to 20 carbon atoms such as. methyl, isopropyl, and butyl esters of fatty acids, and including hexyl laurate, isohexyl laurate, isohexyl palmitate, isopropyl palmitate, decyl oleate, isodecyl oleate, hexadecyl stearate decyl stearate, isopropyl isostearate, diisopropyl adipate. diisohexvl adipate.
  • alkenyl esters of fatty acids having 10 to 20 carbon atoms such as oleyl myristate, oleyl stearate, and oleyl oleate and the like; 6. fatty acids having 10 to 20 carbon atoms, such as pelargonic, lauric, myristic, palmitic, stearic, isostearic, hydroxystearic, oleic, linoleic, ricinoleic, arachidic, behenic, and erucic acids and die like; 7.
  • fatty alcohols having 10 to 20 carbon atoms such as, lauryl, myristyl, cetyl, hexadecyl, stearyl, isostearyl, hydroxystearyl, oleyl, ricinoleyl, behenyl, erucyl, and 2-octyl dodecanyl alcohols are examples of satisfactory fatty alcohols and d e like, 8.
  • fatty alcohol ethers such as ethoxylated fatty alcohols of 10 to 20 carbon atoms including the lauryl, cetyl, stearyl, isostearyl, oleyl. and cholesterol alcohols, having attached thereto from 1 to 50 ethylene oxide groups or 1 to 50 propylene oxide groups: 9.
  • Lanolin and derivatives such as lanolin, lanolin oil, lanolin wax.
  • lanolin alcohols lanolin fatty acids, isopropyl lanolate.
  • ethylene glycol mono and di-fatty acid esters diedrylene glycol mono-and di-fatty acid esters, polyed ylene glycol (200-6000) mono- and di-fatty acid esters, propylene glycol mono- and di-fatty acid esters, polypropylene glycol 2000 monooleate, polypropylene glycol 2000 monostearate, ethoxylated propylene glycol monostearate, glyceryl mono- and di-fatty acid esters, polyglycerol polyfatty esters, ethoxylated glyceryl monostearate, 1,2-butylene glycol monostearate, 1,2-butylene glycol distearate.
  • polyoxyetivylene polyol fatty acid ester, sorbitan fatty acid esters, and polyoxyethylene sorbitan fatty acid esters are satisfactory polyhydric alcohol esters; 12. wax esters such as beeswax, spermaceti, myristyl myristate, stearyl stearate: 13. beeswax derivatives, e.g. polyoxyethylene sorbitol beeswax; 14. vegetable waxes including carnauba and candelilla waxes; 15. phospholipids such as lecitiiin and derivatives; 16. sterol including cholesterol and cholesterol fatty acid esters; 17. amides such as fatty acid amides, ethoxylated fatty acid amides, solid fatty acid alkanolamides.
  • Humectants may be added to the composition to increase the effectiveness of die emollient, to reduce scaling, to stimulate removal of built-up scale and improve skin feel.
  • suitable humectants include polyhydric alcohols, such as glycerol, polyalkylene glycols, alkylene polyols dieir derivatives, propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol, sorbitol, hydroxypropyl sorbitol, hexylene glycol, 1,3-butylene glycol, 1,2,6-hexanetriol, etiioxylated glycerol, propoxylated glycerol and the like.
  • polyhydric alcohols such as glycerol, polyalkylene glycols, alkylene polyols dieir derivatives, propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol, sorbitol, hydroxypropyl
  • the amount of humectant may be in the range of about 0.5-30 wt% and preferably between 1-15 wt%.
  • active substances may be advantageously employed.
  • suitable active agents which may be incorporated into the cosmetic composition include anti-aging active substances, anti-wrinkle active substances, hydrating or moisturizing or slimming active substances, depigmenting active substances, substances active against free radicals, anti- irritation active substances, sun protective active substances, anti-acne active substances, firming-up active substances, exfoliating active substances, emollient active substances, and active substances for the treating of skin disorders such as dermatitis and the like.
  • one or more moisturizers may be used, such as glycerin or urea, in combination with one or more precursor agents for the biosythesis of structural proteins, such as hydroxyproline, collagen peptides and the like.
  • At least one ketolytic agent or an alpha-hydroxyacid such as salicylic acid or 5-n-octanoicsalicylic acid may be used in combination with at least on liporegulating agent such as caffeine.
  • At least one keratolytic agent is used in combination with a depigmenting agent such as hydroquinone, tyrosinasee inhibitor (kosic acid), ascorbic acid, kojic acid and sodium metabisulfite an the like.
  • a depigmenting agent such as hydroquinone, tyrosinasee inhibitor (kosic acid), ascorbic acid, kojic acid and sodium metabisulfite an the like.
  • a depigmenting agent such as hydroquinone, tyrosinasee inhibitor (kosic acid), ascorbic acid, kojic acid and sodium metabisulfite an the like.
  • a depigmenting agent such as hydroquinone, tyrosinasee inhibitor (kosic acid), ascorbic acid, kojic acid and sodium metabisulfite an the like.
  • vitamin E asgainst COO radicals
  • superoxide dismutase asgainst O 2 free radicals
  • sugar and caffeine asgainst OH
  • moisturizers in the case of anti-aging, moisturizers, sunscreens, alpha-hydroxyacids, salicylic acid or surface restructuring agents may be used in combination witii enzymes for the repair of DNA, vascular protective agents or phospholipids rich in oligoelements and polyunsaturated fatty acids.
  • keratolytics such as salicylic acid, sulfur, lactic acid, glycolic, pyruvic acid, urea, resorcinol and N- acetylcvsteine, and retinoids.
  • retinoids such as retinoic acid and its derivatives may be used.
  • non-steroidal anti- inflammatory agents such as propionic acid derivatives, acetic acid, fenamic acid derivatives, biphenylcarboxylic acid derivatives, oxicams. including but not limited to aspirin, acetaminophen, ibuprofen. naproxen. benoxaprofen, flurbiprofen, fenbufen, ketoprofen. indoprofen. pirprofen, carporfen, and bucloxic acid and the like.
  • NSAIDS non-steroidal anti- inflammatory agents
  • Antimicrobial drugs preferred for inclusion in compositions of the present invention include salts of ⁇ -lactam drugs. quinolone drugs, ciprofloxacin, norfloxacin. tetracycline, er ⁇ hromycin. amikacin, triclosan. doxycycline, capreomycin. chlorhexidine, chlortetracycline, oxytetracycline. clindamycin, ed ambutol. hexamidine isethionate, metronidazole, pentamidine, gentamicin. kanamycin. lineomycin. methacycline. methenamine, minocycline, neomycin, netilmicin, paromomycin. streptomycin, tobramycin. miconazole and amanfadine and the like.
  • suitable agents include 2-ed ylhexyl p-methoxycinnamate, 2-ethylhexyl N.N-dimethyl-p- aminobenzoate, p-aminobenzoic acid, 2-phenyl p-meti oxycinnamate, 2-eti ⁇ ylhexyl octocrylene, oxybenzone, homomenmyl salicylate, octyl salicylate, 4,4' -methoxy- 1- butyldibenzoylmethen, 4-isopropyl dibenzoylmediane, 3-benzylidene camphor, 3-(4- methylbenzylidene) camphor, titanium dioxide, zinc oxide, silica, iron oxide, and mixtures thereof and the like.
  • the sunscreening agents disclosed therein have, in a single molecule, two distinct chromophore moieties which exhibit different ultra-violet radiation absorption spectra.
  • One of the chromophore moieties absorbs predominantly in the UVB radiation range and the otiier absorbs strongly in die UNA radiation range.
  • These sunscreening agents provide higher efficacy, broader UN absorption, lower skin penetration and longer lasting efficacy relative to conventional sunscreens.
  • the sunscreens can comprise from about 0.5% to about 20% of die compositions useful herein. Exact amounts will vary depending upon the sunscreen chosen and the desired Sun Protection Factor (SPF). SPF is a commonly used measure of photoprotection of a sunscreen against erythema.
  • tanning agents include, dihydroxyacetone, glyceraldehyde. indoles and their derivatives, and the like.
  • the composition may include cleansing surfactants.
  • Cleansing surfactants are cationic, anionic. amphoteric or non-ionic surfactants which are water-soluble and produce a consumer-acceptable amount of foam.
  • ⁇ onionic surfactants are well-known materials and have been used in cleansing compositions. Therefore, suitable nonionic surfactants include, but are not limited to, compounds in the classes known as alkanolamides, block copolymers of ethylene and propylene. ethoxylated alcohols, ethoxylated alkylphenols, alkyl polyglycosides and mixtures diereof.
  • die nonionic surfactant can be an ethoxylated alkylphenol.
  • alkylphenol having an alkyl group containing from about 6 to about 12 carbon atoms in either a straight chain or branched chain configuration with ethylene oxide, d e etirylene oxide being present in an amount equal to at least about 8 moles ethylene oxide per mole of alkylphenol.
  • Examples of compounds of this type include nonylphenol condensed with about 9.5 moles of ethylene oxide per mole of phenol; dodecylphenol condensed with about 12 moles of ediylene oxide per mole of phenol; dinonylphenol condensed widi about 15 moles of ethylene oxide per mole of phenol; octylphenol condensed with about ten moles of ethylene oxide per mole of phenol; and diisooctyl phenol condensed with about 15 moles of ethylene oxide per mole of phenol.
  • a wide variety of acids, bases, buffers, and sequestrants can be utilized to adjust and/or maintain die pH and ionic strengtii of die compositions useful in d e instant invention.
  • Materials useful for adjusting and/or maintaining d e pH and/or d e ionic strength include sodium carbonate, sodium hydroxide, hydrochloric acid, phosphoric acid, sulfuric acid, acetic acid, sodium acetate, sodium hydrogen phosphate, sodium dihydrogen phosphate, citric acid, sodium citrate, sodium bicarbonate, triethanolamine, EDTA, disodium EDTA, tetrasodium EDTA, and the like.
  • the polymer network may be useful as a solubilization agent in cosmetic and personal care applications.
  • a self-assembling system comprising the reversibly gelling polymer network exhibits thermogelation. pH sensitivity, and d e ability to solubilize hydrophobic agents in aqueous media.
  • PAA poly(acrylic acid)
  • the resulting copolymer network is bioadhesive and can be applied in a number of therapies.
  • the materials described in this invention combine "reverse" thermoviscosification mucoadhesion, solubilization of hydrophobic and difficult to manage moieties, easy formulation, and protection of agents from degradation to provide a superior medium for cosmetic and personal care products.
  • d e polymer network will have the ability to act as a primary emulsifier witiiout any (or with very little) addition of traditional surfactant.
  • the responsive polymer network will also act as a stabilizer for oil-soluble ingredients that would conventionally need to be solubilized by oils in formulation.
  • the hydrophobic portion of the polymer network (PPO) forms domains which act as reservoirs for an oil- soluble or hydrophobic additive, such as an oil droplet, as is illustrated in Figure 9.
  • poloxamer:poly(acrylic acid) polymer network compositions are valuable materials in the formulation of cosmetic and personal care products.
  • they may be useful as rheology modifiers, provide a cushioning effect on :ne skin, offer barrier properties and controlled release of actives.
  • the polymer composition may serve as a surfactant and is compatible with most ingredients used in the cosmetic industry.
  • the above properties of the poloxamer:poly(acrylic acid) polymer network provides a cosmetic composition that spreads evenly and smoothly and which leaves a lubricious feel to the skin.
  • a sensory evaluation was conducted with seven random volunteers in order to determine the sensory effect of a cream formulation on the skin.
  • An oil-free cosmetic formulation was prepared substantially as set forth in Example 33(b) and was compared to Nivea Oil Free, a product of Beiersdorf of Germany.
  • the aggregation process may be understood as occurring as shown in Figure 10, in which a backbone 20 represent poly( acrylic acid), a thin band 24 represents the hydrophobic poly(propylene) glycol region of the poloxamer and a thick band 26 represents the hydrophilic poly(ethylene glycol) region of the poloxamer.
  • a backbone 20 represent poly( acrylic acid)
  • a thin band 24 represents the hydrophobic poly(propylene) glycol region of the poloxamer
  • a thick band 26 represents the hydrophilic poly(ethylene glycol) region of the poloxamer.
  • the polymer network is randomly arranged, as is shown in Figure 10(a).
  • the hydrophobic regions 24 associate to form aggregations or micelles 28, as is shown in Figure 10(b).
  • the association increases die effective molecular weight of die polymer network composition with the corresponding increase in viscosity.
  • a general method of making the poloxame ⁇ PAA polymer network compositions of the present invention comprises solubilization of the poloxamer in acrylic acid monomer, followed by polymerization of the monomer to P.AA.
  • Polymerization may be accomplished by addition of a polymerization initiator or by irradiation techniques.
  • the initiator may be a free radical initiator, such as chemical free radical initiators and uv or gamma radiation initiators. Conventional free radical initiators may be used according to the invention, including, but in no way limited to ammonium persulfate. benzoin ethyl ether, benzyl peroxide.
  • the poloxamer component may be dissolved in an acrylic acid/water mixture instead of pure monomer. It may be desirable to remove unreacted monomer and or free poloxamer from the resultant polymer network. This ma ' y be accomplished using conventional techniques, such as. by way of example, dialysis or sohxlet extraction.
  • the scheme for bonding of poloxamer to acrylic acid may involve initiation (eq 1), hydrogen abstraction from the propylene or ethylene moiety of me poloxamer (eq 3), and attachment to acrylic acid via addition across the unsaturated bond (eq 10). Propagation (eq 8) leads to the final PAA.
  • the mechanism may proceed by initiation according to eqs. (1) and (2). propagation to form PAA (eq.8), a chain transfer reaction to generate a reactive poloxamer moiety (eq. 5), followed by addition of die reactive poloxamer moiety to die unsaturated bond of acrylic acid (eq. 10) and subsequent propagation of the PAA chain.
  • the polymer network may include a plurality of poly(acrylic acid)) units bonded to a single poloxamer unit or, alternatively, a plurality of poloxamer units bound to a single PAA backbone. Combinations of tiiese alternatives are also a possibility.
  • Reverse phase polymerization may be used to prepare polymer network beads by dispersion of the poloxamer and acrylic acid monomer mixture in a nonpolar solvent such as hexane or heptane.
  • the aggregating polymer/monomer solution is dispersed with agitation in the nonpolar solvent in order to suspend droplets of the solution.
  • Polymerization of the monomer is initiated by conventional means (i.e.. addition of a initiator or irradiation) in order to polymerize the monomer and form responsive polymer network beads. See, U.S.S.N. 08/276.532 filed July 18, 1995 and entitled “Useful Responsive Polymer Gel Beads" for further information on the preparation of polymer gel beads, herein incorporated by reference.
  • Such a method may be particularly desirable to provide a heat sink for the heat generated in the exothermic polymerization reaction.
  • polymer network complexes and aqueous gelling solutions of d e present invention may be understood with reference to the following examples, which are provided for the purposes of illustration and which are in no way limiting of the invention.
  • Example 1 This example describes d e syntiiesis of a polymer network and an aqueous responsive polymer network solution prepared using a triblock polymer of poly(ethylene glycol) and poly(propylene glycol), Pluronic® F27 polyol, and poly(acrylic acid). This example also characterizes the gelation and d e physical properties of the resultant polymer network.
  • Block copolymer of poly(propylene glycol) (PPG) and polyethylene glycol) (PEG) having triad ABA structure (PEG) A (PPG) B (PEG) A (Pluronic® F127 NF polyol, Poloxamer 407 NF polyol, where "F” means Flakes, "12” means 12X300 3600 - MW of the PPG section of the block copolymer, "7” PEG in die copolymer is 70 wt%, and nominal molecular weight is 12,600) from BASF (3.0 g) was dissolved in 3.0 g acrylic acid (Aldrich).
  • Viscosity measurements A known amount of me resultant polymer was suspended in 100 ml deionized water into which NaOH was added. Following swelling for 3 days while stirring, the pH of the resulting fine suspension was adjusted to 7. Samples of 15 ml each were taken, and pH in each vial was adjusted to desired value by addition of 1 M HCl or NaOH. Samples were then kept overnight and their viscosities were measured at different temperatures using Brookfield viscometer using either an SC4-18 or an SC4-25 spindle.
  • Figure 12 is a viscosity vs. temperature graph comparing the gelling characteristics of d e responsive polymer network composition and die physical blend.
  • the blend prepared by physically mixing of the triblock PEG/PPG/PEG polymer and poly(acrylic acid) did not exhibit viscosifying effect eitiier as a function of temperature or pH.
  • Example 2 This example describes a standard operating procedure for the manufacture of the reversible gelling polymer network.
  • a NaOH solution was prepared by dissolving 131.8 g NaOH pellets in 131.8 mL Dl water (50% solution). The NaOH was allowed to dissolve completely. The NaOH solution will be used to convert a percentage of the acrylic acid to sodium aery late in situ.
  • Acrylic acid monomer 4 kg is charged into a monomer feed tank and agitated at 250 rpm. NaOH is added slowly. The precipitate formed as the acrylic acid is ueutralized to sodium acrylate is allowed to dissolve.
  • Pluronic® F127 (3.5 kg) is slowly added to die monomer feed tank. Pluronic® F127 is dissolved under continued agitation.
  • Norpar 12 (a refined C-12 alkane) is added to d e reaction vessel (37 L). The mixture is agitated at 100 rpm. Stabilizer solution of Ganex V-126 is prepared in 2L Norpar 12 and added to the reactor under agitation. A reaction vessel was degassed using a nitrogen sparge introduced from the bottom of reactor and was continued throughout the reaction. Initiator (13.63 g Lauryl peroxide and 4.23 g Vazo 52 in 0.7 kg acrylic acid monomer) is introduced into die monomer solution. The monomer solution was transferred to the reaction vessel. Agitation was increased to 150 rpm. Nitrogen sparging continued for an additional 20 minutes and then heating began. Heating began at a rate of 0.5-1.0 X/min up to
  • the reaction began to exotherm at about 45-50 X and is allowed to continue witiiout cooling until a maximum is reached. It is ien cooled to 75 X using forced cooling. The reaction continued for 12 hours and was d en cooled to 35 X.
  • the slurry was transferred into pails and the polymer beads were allowed to settle. The slurry was filtered through Buchner Funnels with filter paper (11 ⁇ m pore size) until the bulk of die Norpar had been removed from the beads. The beads were washed d ree times with heptane. The filtered beads were transferred to a Pyrex drying tray and spread on die tray in a uniform layer. The beads were dried under vacuum for 4 hours at 40-50 X. The dried beads were analyzed as follows. Elemental analysis. The elemental analysis was performed by Quantitative
  • TGA Thermal Gravimetric Analysis
  • the effect of botii die bonded and non-bonded poloxamer on the gelation properties of the responsive polymer network has been determined by extraction of d e non-bonded poloxamer from die material.
  • Such extraction studies have established diat die graft co-polymer alone exhibits the characteristic reverse thermal gelation of the composition; however, the presence of non-bonded poloxamer component modulates d e gelation process.
  • the non-bonded poloxamer component can affect d e temperature of transition (from liquid to gel) and die degree of transition and assists in a more controlled and reproducible transition.
  • Bound poloxamer determination bv ethylene oxide fEO titration was performed as follows. A 5 gm sample of the product polymer was extracted in dichloroethane for three hours at reflux temperatures. The solid is removed and dried under a vacuum for 12 hours at room temperature. The dry material is then analyzed using ASTM method D 2959-95, "Standard Test Method for Ethylene Oxide Content". The amount of EO in the sample is related to the amount of poloxamer bound to the polymer. The typical result is approximately 15 % by weight of EO. The relative amount of free poloxamer may be varied dependent upon die relative proportions of starting materials and the method of polymerization.
  • d e residual solids presumably contain only poloxamer which is bonded to die poly(acrylic acid), i.e. , a graft co-polymer, the material still shows strong viscosification when it is neutralized and dissolved in water.
  • the temperature of viscosification is increased substantially and d e degree of viscosification per gram of total solids is increased by removal of free poloxamer.
  • die free poloxamer plays a role in modifying d e extent and temperature of viscosification.
  • the poloxamer undergoes conformational changes and changes to die critical micelle concentration as a function of temperature.
  • the poloxamer will change from an open, non-aggregated form to a micellular, aggregated form with changes in temperature.
  • Residual acrylic monomer determination by gas chromatography was determined by GC analysis using a Hewlet Packard GC 5890A, using a HP-FFDAP-TPA 10 m x 0.53 mm x l ⁇ m column. The sample was extracted and run in metiianol. Using an internal standard ratio, the sample was compared to a one point calibration. The typical results for this assay were below 70 ppm acrylic acid monomer.
  • Residual Norpar solvent bv GC Residual Norpar solvent bv GC.
  • the residual Norpar in d e sample was determined by GC using the above method and comparing the Norpar peaks to that of a standard. The typical results were below 1.5 wt%.
  • Differential scanning calorimetrv fDSCV The DSC was performed by Massachusetts Material Research. Inc.. West Boylston. MA using a temperature ramp from 30 to 350 X at 5 X/min. The resolution for the system was set to 4 (l.OX/min for all slope changes). The assay yielded one endothermic event at 265 X, typically 270 J/g.
  • Example 10 The following example demonstrates the effect of hydrophilic/hydrophobic ratio on the gelling temperature.
  • Polymer network compositions were prepared from the following poloxamers shown in Table 3. Table 3. Composition of poloxamers investigated.
  • the poloxamer (3.0 g) was dissolved in 3.0 g acrylic acid. The solution was deaerated by N 2 bubbling for 20 min. and following addition of the 100 :1 of freshly prepared saturated solution of ammonium persulfate in deionized water was kept at 70 °C for 16 h resulting in a strong whitish polymer. A sample of the polymer obtained (0.4 g) was suspended in 40 ml deionized water into which NaOH was added. Suspended responsive polymer network particles were allowed to dissolve under constant stirring. The resulting 1 wt% polymer network solutions were subjected to die viscosity measurement at shear rate of 132 or 13.2 sec using a SC4- 18 spindle.
  • Example 11 The following example is related to release of and active agent from a poloxamer: poly(acry lie acid) polymer network. Drug loading and kinetics of release of the protein hemoglobin from poloxamer:poIy(acryIic acid) polymer network is described.
  • Pluronic ® F127 (3.0 g) was dissolved in 3.0 g acrylic acid. The solution was deaerated by N 2 bubbling for 0.5 h and following addition of 100 FI of freshly prepared saturated solution of ammonium persulfate (Kodak) in deionized water was kept at 70°C for 16 h resulting in a transparent polymer. The resultant responsive polymer network obtained (5 g) was suspended in 95 ml deionized water into which NaOH was added. The resulting suspension was allowed to swell for 7 days.
  • a 5 wt% responsive polymer network composition (3 g) was allowed to swell for 16 h in 10 ml of 0.25 mg/ml solution of human hemoglobin (Sigma) in deionized water adjusted to pH 8. The resulting mixture was well shaken and placed into the feed chambers of customized vertical, static, Franz-like diffusion cells made of Teflon. The feed and receiver chambers of the diffusion cells were separated by mesh screens (# 2063). The receiver chamber was continuously stirred by a magnetic bar. The cells were allowed to equilibrate to either 25 or 37 °C (in an oven).
  • the feed and receiver phases consisted of 1 g of the hemoglobin-loaded responsive polymer network and 6 ml of phosphate-buffered saline (pH 7.4), respectively.
  • d e feed phase was made of 1 g of 0.25 mg/ml hemoglobin solution.
  • Samples of the receiver phase was withdrawn from time to time and their absorbance was measured spectrophotometrically at 400 nm.
  • corresponding calibration curves (absorbance in PBS versus hemoglobin concentration) were generated. The results of the kinetic experiment are presented in Figure 17.
  • Example 12 The following example is related to release of an active agent from a poloxamer: poly (aery lie acid) poiymer network. Drug loading and kinetics of release of the protein lysozyme from a polymer network is reported.
  • Lysozyme loading and release A 5 wt% responsive polymer network composition (3 g) was allowed to swell for 16 h in 10 ml of 1 mg/ml solution of chicken egg-white lysozyme (Sigma) and 1.5 mg/ml sodium dodecyl sulfate (Aldrich) in deionized water adjusted to pH 8.5. The resulting mixmre was well shaken and placed into the feed chambers of customized vertical, static, Franz-like diffusion cells made of Teflon. The feed and receiver chambers of the diffusion cells were separated by mesh screens (# 2063). The receiver chamber was continuously stirred by a magnetic bar. The cells were allowed to equilibrate to either 25 or 37 °C (in an oven).
  • the feed and receiver phases consisted of 1 g of the lysozyme-loaded responsive polymer network and 6 ml of phosphate-buffered saline (pH 7.4), respectively.
  • the feed phase was made of 1 g of 1 mg/ml lysozyme solution.
  • the kinetic time commenced. Samples were withdrawn and their absorbance measured spectrophotometrically at 280 nm.
  • a calibration curve was prepared for lysozyme concentration ranging from 0 mg/ml to 0.5 mg/ml in phosphate buffered saline. The results of the kinetic experiment are presented in Figure 18.
  • Example 13 The following example is related to release of an active agent from a poloxamer:poly(acrylic acid) polymer network. Drug loading and kinetics of release of insulin from a responsive polymer network composition is reported. Insulin loading and release. A 5 wt% responsive polymer network composition (3 g) was allowed to swell for 16 h in 10 ml of 5 mg/ml solution of bovine Zn 2+ -insulin (Sigma) in deionized water adjusted to pH 7. The resulting mixmre was well shaken and placed into the feed chambers of customized vertical, static, Franz-like diffusion cells made of Teflon. The feed and receiver chambers of the diffusion cells were separated by mesh screens (# 2063). The receiver chamber was continuously stirred by a magnetic bar.
  • the cells were allowed to equilibrate to either 25 or 37 °C (in an oven).
  • the feed and receiver phases consisted of 1 g of the insulin-loaded responsive polymer network and 6 ml of phosphate-buffered saline (pH 7.4), respectively.
  • the feed phase was made of 1 g of 5 mg/ml insulin solution. After the feed solution had been loaded into the cell, d e timing commenced. Samples were withdrawn and their absorbance was measured spectrophotometrically at 280 nm. A calibration curve was prepared for insulin concentration ranging from 0 mg/ml to 1.25 mg/ml in phosphate buffered saline. The results of the kinetic experiment are presented in Figure 19.
  • the rate of insulin release from responsive polymer network was substantially lowered at 37 °C when compared to that at 25 °C, because of viscosity increase in responsive polymer network at elevated temperamres (see Figure 1).
  • Example 14 This example demonstrates the preparation of a sterile reversibly gelling polymer network aqueous composition and die stability of die composition to sterilization.
  • the polymer network is prepared as described in Example 1 , except that die composition is prepared at 2 wt% Pluronic ® F127 polyol/poly (aery lie acid). After dissolution of the 2 wt% polymer network in water, the viscosity is measured. The composition dien is sterilized by autoclaving at 121 °C, 16 psi for 30 minutes. Viscosity is determined after sterilization. The corresponding curves for viscosity (a) before and (b) after sterilization are shown in Figure 20 and establish that minimal change in die viscosity profile of d e material has occurred with sterilization.
  • Examples 15-30 show additives which may be used to affect die transition temperature overall viscosification of the polymer network composition.
  • a 1 wt% polymer network was prepared in deionized water at pH 7 in which a variety of additives were included in d e composition. The effect of the additive was determined by generation of a Brookfield viscosification curve. Results are reported in Table 4.
  • Example 31 Because of the surfactant nature of the polymer network composition coupled with the gelation effect of d e polymer network composition, it is possible to prepare formulation which are 100% water-based, but which are lubricous and thick.
  • Formulations including a nonionic surfactant formulation An O/W (oil-in- water) emulsion was made by combining me following ingredients utilizing conventional mixing techniques:
  • Formulations including a cationic surfactant formulation An O/W (oil-in- water) emulsion was made by combining the following ingredients utilizing conventional mixing techniques:
  • Formulations including an anionic surfactant formulation An O/W (oil-in- water) emulsion was made by combining me following ingredients utilizing conventional mixing techniques:
  • Example 32 An oil-free, clear, anti-acne treatment is made by combining the following ingredients utilizing conventional mixing techniques:
  • die contents of die first vessel is added to die second vessel, and allowed to mix to homogeneity.
  • the composition displays a flowable clear jelly appearance with excellent spreadability and absorption characteristics at room temperamre, and after heating the formulation to 32°C, the composition thickens to a gel-like consistency.
  • Example 33 (a) Oil-free Moisturizer (formulation I): An oil-free, lubricous moisturizer was made by combing the following ingredients utilizing conventional mixing techniques:
  • the above ingredients were added and processed as described above for the acne composition.
  • the composition displayed a flowable creamy lotion appearance with excellent emolliency, spreadability and absorption characteristics at room temperamre. After heating the formulation to above 26 °C, die composition thickened to a gel-like consistency.
  • the viscosity vs. temperamre curve is shown in Figure 21 and demonstrates that addition of adjuvants to the composition significantly enhances the responsive polymer network maximum viscosity ( > 900,000 cps).
  • the use of the poloxamer: poly(acry lie acid) polymer network in the formulation also imparts a unique viscosification effect after application to the skin, which is not evident in typical commercial O/W emulsion formulations (See, Figure 21b).
  • Oil-free Moisturizer (formulation II): An oil-free, lubricious moisturizer was made by combing the following ingredients utilizing conventional mixing techniques: Table 10.
  • the above ingredients were added and processed as described above for the acne composition.
  • the composition displayed a flowable creamy lotion appearance with excellent emolliency, spreadability and absorption characteristics at room temperamre.
  • me composition thickens to a gel-like consistency.
  • the addition of adjuvants to the composition sigmficantly enhances the polymer network maximum viscosity.
  • Example 34 Sunscreen Lotion. An oil-free, lubricious sunscreen lotion was made by combining the following ingredients utilizing conventional mixing techniques:
  • the above ingredients were added and processed as described above for the acne composition.
  • the composition displayed a flowable creamy lotion appearance with excellent emolliency, spreadability and absorption characteristics at room temperamre. After heating the formulation to above 26 . the composition thickened to a gel-like consistency.
  • the addition of adjuvants to the composition significantly enhances die polymer network maximum viscosity.
  • Example 35 Facial mask. A face mask was made by combing the following ingredients utilizing conventional mixing techniques:
  • the above ingredients were added and processed as described above for the acne composition.
  • the composition displayed a flowable creamy lotion appearance with excellent emolliency, spreadability and absorption characteristics at room temperamre.
  • d e composition thickened to a gel-like consistency.
  • the addition of adjuvants to die composition significantly enhances me polymer network maximum viscosity.
  • Example 36 Facial toner.
  • a face mask was made by combing the following ingredients utilizing conventional mixing techniques:
  • the above ingredients were added and processed as described above for the acne composition.
  • the composition displayed a flowable appearance with excellent emolliency, spreadability and absorption characteristics at room temperamre. After heating the tormulation to above 26 X, the composition thickened to a gel-like consistency.
  • the addition of adjuvants to the composition significantly enhances the polymer network maximum viscosity.
  • Example 36 Solubilization studies of model hydrophobic agents in the poloxamer: polv(acrylic acid) polymer network: estradiol and progesterone. This example is presented to demonstrate the solubilization of a hydrophobic agent in d e polymeric network. Progesterone and estradiol were used as d e hydrophobic agents in this model solubilization study.
  • Acrylic acid (99%), fluorescein (98%), / 3-estradiol (98%), and progesterone (98%) were all obtained from Aldrich and used as received.
  • Pluronic ® F127 NF was obtained from BASF.
  • Poly(oxyethylene-b-oxypropylene-b-oxyethylene)-g-poly(acrylic acid) copolymers (responsive polymer network ) were synthesized by free-radical polymerization of acrylic acid in the presence of poloxamer as described above.
  • the polymer network copolymers discussed here were composed of about 1 : 1 ratio of PAA to poloxamer.
  • the rheological properties of polymer network were assessed using LVDV-II-. and RVDV-II + Brookfield viscometers.
  • the microscopic light scattering of 21 nm poly(styrene) latex particles in deionized water and 1 w% reversibly gelling polymer network was measured using He-Ne laser as described previously (See, Matsuo, E.S. , Orkisz, M. , Sun, S.-T. , Li, Y. , Tanaka, T., Macromolecules, 1994, 27, 6791).
  • the solubility of fluorescein and hormones in aqueous solutions was measured by d e equilibration of excess solubilizate witii the corresponding solution following removal of undissolved species by centrifugation and filtration.
  • Hydrophobic agents were assayed spectrophotometrically at 240 (progesterone) or 280 nm (estradiol), or by using 70/30 w/w H 2 SO 4 /MeOH (Tsilifonis-Chafetz reagent).
  • In vitro hormone release studies were conducted using thermostatted, vertical Franz cells. Spunbonded polypropylene microfilters (micron retention, 15-20) were used as a membrane separating feed and receiver phases in Franz cells. The responsive polymer network, water, ethanol, and 20% PEG in water were observed to wet the membrane. The receiver solutions consisted of 20 w% PEG in water (pH 7) and were stirred by magnetic bars. The feed phases composed of responsive polymer network were loaded widi eitiier estradiol or progesterone. Each hormone was dissolved in etiianol and the resulting solution was added into the responsive polymer network.
  • ⁇ G -RTlnP
  • ⁇ H -R ⁇ lnP/ ⁇ (l/T)
  • ⁇ S ( ⁇ H - ⁇ G)/T (14)
  • Negative ⁇ G values indicate spontaneous solubilization at all temperamres, whereas positive ⁇ H shows that the solubilization was endothermic, similar to the solubilization of estriol, as well as indomethacin, by d e poloxamer.
  • ⁇ S of solubilization was always positive, suggesting d at die more ordered water molecules surrounding hydrophobic estradiol molecules moved to d e less ordered bulk phase when d e estradiol was transferred to the hydrophobic core of PPG segments in responsive polymer network.
  • the aggregation of the PPG segments at elevated temperamres provides not only temporary cross-linking in the gel, but also a diermodynamically "friendly" environment for the hydrophobic drugs. Indeed, one can express the free energy of formation of the aggregate core-water interface in responsive polymer network as:
  • Equation (3) shows that solubilization of a hydrophobic drug of high ⁇ WD should increase the stability of d e aggregate. The solubilization process was found to decrease the critical micellization concentration and substantially increase the micellar core radius in Pluronic surfactants (Hurter, P.N. et al.
  • Figure 27 shows that the relative amount of progesterone penetrating into the receiver phase decreased 4-fold with the increase of total polymer concentration, whereas the total relative amount of progesterone stayed almost constant as t ⁇ tal polymer concentration in the responsive polymer network increased.
  • This result shows the existence of two routes of transport of hydrophobic drugs in our model system. Firstly, the drug inco ⁇ orated into aggregates within die responsive polymer network system can flow dirough the membrane along with die erosion of the responsive polymer network; secondly, the drug not associated wid die responsive polymer network aggregates can diffuse out of the responsive polymer network in the feed phase. The second process should not be related to die viscosity of the responsive polymer network.
  • Abrasive abrades, smoothes, polishes
  • Emollient softens, smoothes skin
  • Emuisifier a surtace-acuve agent (surfactant) that promotes the formation ot water-in-oil or oil-in-water emulsions
  • Absorption base torms water-in-oil emulsions
  • Enzymes complex proteins produced by living cells that catalyze biochemical
  • Aciduient acidifies, lowers pH. neutralizes alkalis reacuons at body temperature
  • Amphote ⁇ c capable of reacting chemically either as an acid or a base:
  • Fiber strands of natural or synthetic polymers for instance, conon. wool, silk, amphoienc surfactants are compatible with anionic and cationic nylon, polyester surfactants
  • Analgesic relieves pain after application to a surface
  • Antacid neutralizes stomach acidity
  • Antibacterial, destrovs mhibits the growth/reproduction of bacte ⁇ a aroma
  • Anti-caking prevents or retards caking of powders, keeps powders free- Flavor, impa ⁇ s a characteristic taste (and aroma) to edible foods and d ⁇ nks. flowing sometimes used in lip products
  • Anti-dandruff retards or eliminates dandruff Foam booster enhances quality and quantity of lather of shampoos
  • Antifoam suppresses loam during mixing
  • Foamer a surface-acuve agent (surfactant) that produces foam, an emulsion ol
  • Anti-irritant reduces, suppresses or prevents lmtauon Foam stabilizer see Foam booster
  • Geilant a gelling agent: forms gels: includes a wide va ⁇ erv of mate ⁇ als such
  • Antioxidant inhibits oxidation and rancidity as polymers, ciavs and soaps
  • Antiperspirant reduces or inhibits perspiration Glosser- tu ishes a surface luster or b ⁇ ghtness. usuallv used in lip or hair products
  • Antipruritic reduces or prevents itching
  • Antiseptic inhibits the growth of microorganisms on the skin or on living tissue Hair conditioner see Conditioner
  • Antistat reduces static by neutralizing electrical charge on a surface Hair dye imparts a new permanent or semi-permanent color to hair
  • Astringent contracts organic tissue otter application Hair-set polymer polvmer and/or resins used to maintain desired hair shape
  • Binder- promotes cohesion ot powders Hair-set resin see Hair-set polymer
  • Bleaching agent lightens color, oxidizing agent Hair waving: see Reducing agent and Neutralize!-
  • Buffer helps maintain original pH (acidity or basicity) of a preparation
  • Hydrotrope enhances water solubility
  • Carrier- a vehicle or base used for a preparation Intermediate basic chemicals which are chemically modified to obtain the desired function
  • Chelate form a complex with trace-metal impurities, usually calcium or iron
  • Lathering agent a surface active agent (surfactant) that torms a loam or lather
  • Colorant adds color, may be a soluble dye or an insoluble pigment on mixing with air in solution: see also Foamer
  • Lubricant reduces f ⁇ cuo ⁇ . smoothes, adds slip
  • Coupling agent aids in solubilization or emulsificauon of incompauble
  • Moisture barrier retards passage of moisture or water components
  • Moisturizer aids in increasing die moisture content of the skin through
  • Decolorant removes color bv adsorption, bleaching or oxidation humectant or barrier action
  • Denaturant used to denature ethyl alcohol
  • Deodorant destroys, masks or inhibits formation of unpleasant odors
  • Oil absorbent see Absorbent powder
  • Depilatory- removes hair chemically Ointment base, an anhydrous mixture of oleaginous components used as a
  • Detergenf a surface-active agent (surfactant) that cleans by emulsifying oils vehicle for medicaments and suspens paniculate soil Opacifier opacifies clear liquids or solids
  • Oxidant oxidizing agent neutralizes reducing agents, bleaching agent
  • Dispersant promotes the formation and stabilization of adispersion or suspension Pearlant imparts a pearlescent texture and luster
  • Pigment a tinelv powdered insoluble substan-e used to import color luster or Stimulant produces a temporary increase in the tunctional octivitv ot an opocitv organism or ⁇ nv ot its pans
  • Surfactant I surface active agent lowers surface tension between two
  • Polish smoothes adds doss and luster or more incompatible phases soaps detergents wetting agents solubizin- agents and emuisifving agents are tvpical surtactams
  • Polvmer ⁇ verv high molecular wei ⁇ ht compound consisting ot repealing surtactants areclassitiedasanionic canonic nonionic and amphotenc structural units anionic surtactams are negativelv charged Lanonic surtactams have
  • Reducing agent reduces a chemical compound usuallv bv donatins electrons Thixotrope the propertv ot certain aels and emulsions ot becomin- more fluid neutralizes oxidizing agents or less viscous when shaken or suited
  • Refatting agent adds oils materials lo ihe surtaLe ot substrates e g skin and UV absorber used as a sunscreen and to protect preparations trom dearadation hair by UV radiation
  • Resin nonvolatile solid or semisolid organic substances obtained from plants UVA absorber jbsoros in the range 20 -400 nanometers mm) as exudates to prepared bv polvme ⁇ zation ot simple molecules
  • UVB absorber absorbs in the range 290 _0 nanometers inmi
  • Siiicone poh e ⁇ c organic silicon compounds which are water resistant contain principally esters ol higher tattv acids and higher lattv alcohols tree
  • Skin protectant protects skin trom en ironmental fattv alcohols lattv acids and hvdrocarbo ⁇ s mav also be present waxes derived trom petroleum products are mainlv high-molecular weight
  • Solubilizer s ⁇ lubi zes usuallv into aqueous vehicles normally insoluble hydrocarbons materials SUL ⁇ as tragrances tlovors oils etc
  • Solvent usuallv liquids capable ot dissol ing other substances interfacial tension facilitating the wetting ot surfaces
  • Jojoba (Buxus chinensis) seed powder Taita ⁇ c acid Serum protein
  • Bladder rack Fucus vesiculosus extract Willow (Salix alba) extra ⁇ Phenyi mercu ⁇ c acetate, Pm benzoate, Pm borate
  • Butcherbroom Ruscus aculeatus extract
  • hazei Haamame s virgimana
  • Rosemarv Rosma ⁇ nus officinalis extract 1- ys ⁇ ne laurovl methionine Ascorbvl oleate. A. palmitate
  • Butcherbroom Ruscus aculeatus extract Soy (Glv ⁇ ne soja) protein p- Hydro xvamsoie
  • Horee chesmut (Aesculia hippocastanum) extract Cetethvldunomum bromide Sage (Salvia officinalis) extra ⁇
  • Aluminum undecvienovl collagen ammo acids PPG-9 diethvlmo um chlo ⁇ de
  • Zinc lactate Aluminum zirconium pentachiorhvdrate PPG-25 diethylmonium chlo ⁇ de
  • Entada phaseoloides extract Isostearvl neopentanoate ammonium ethvi sulfate
  • Eucalvptus (Eucalyptus globulus) extract Wheat ge ⁇ namidopropvl ethvldunomum ethosulfate Maltodext ⁇ n
  • Tormentil extract Euphrasia officinalis extract Tapioca dextnn
  • Astraealus si ⁇ icus extract Cvpress (Cupressus sempervirens) extract Job s tears (Coix lacryma jobu extract
  • Banana Melana (Musa sapie ⁇ tumi extract Doe rose (Rosa cani ⁇ ai hips extract Kiwi (Actimdia chinensis) fruit extract seed oil
  • Bearberrv i Arciostaphvlos uva ursi extract extract Lady s mantle (Alchemilla vulaa ⁇ s) extract
  • Butcherbroom i Ruscus aculeatus extract Ginkgo biloba extract Mangold Cabbage rose I Rosa -entiloliai extract Ginsena ( Panax ginseng) extract Ma ⁇ ne silts Calamus l A ⁇ or ⁇ s calamus I extract Glvcyrrhetinic acid Mat ⁇ cana (Chamomilla recutitai xtract Calendula officinalis extract Glvcyrrhizic acid Meadowsweet (Spiraea ulma ⁇ ai extract Caper (Cappa ⁇ s spinosai extract Glvcvrrhizin ammoniatcd Melon (Cucumis elo) extrau Capsicum trutesce ⁇ s extrau C t oleoresin Golden seal ( Hvdrastis canadensisl root extract MEA iodine Carawav i Camm can 11 extract Goldthread (Coptis japomca I extract Mistleto
  • Clover I T ⁇ tolmm pratensei extract Hops Humuius lupulus I extract Papava iCanca papavai extract Cmdium otficinale rhizome extract C o water
  • Coltsfoot (Tussilaao tartarai leat extract Houttuv a cordata extract Pea ( isum sativum ) extract Comtrev i Svmphvium uitn-inalei leat extrau Hyacinth ( Hvacinthus o ⁇ e ⁇ talis ) extract Peach (Prunus persica I exu-act leat extract Conduranao extract Hydrototvl (Centella asiaticai extract Pelareo ⁇ ium capitatum extract
  • Topical applications or HIV + Lymph-nodes Tel (65) - 7653292 Full Colour Fax (65) - 7653293 Siddha Extracts for post-Chemotheraphy Skin-Damage Treatment PC - Video Teleconferencing (65) 7653292 - For Tech Assistance Functions
  • Pineapple (Ananas sativus i extract Wild agnmonv ( Potenulla anse ⁇ na) extract Tetrahydroxypropyl ethylenedia ⁇ une
  • Plantain Plantain (Plantago major) extract Wild cherry (Prunus serouna) bark extract Tetrasodium EDTA
  • Rhodophvcea extract Cit ⁇ c acid Dandelion (Taraxacum officinale) extract
  • Rhubarb heum palmatuml extract Ethanolamine HCl Echitea glauca extract
  • Saponana orficinalis extract Acrvlates copolymer. sphe ⁇ cal powder Lysimachia toenum-graecum extract
  • Sov Glvcine soiai germ extract, protein, sterol Methvl propanediol Cleansing
  • Swe ⁇ ia chirata extract Tapioca dext ⁇ n 6-(N-Acetvlam ⁇ no ⁇ -4-oxvhexvltnmon ⁇ um chlo ⁇ de
  • Thvme Thvmus vulga ⁇ si extract beta-Alanine diacetic acid Adipic acid/dimethvlaminohvdroxvpropyl
  • Tomato Solanum Ivcopersicum extract Calcium disodium EDTA diethylene t ⁇ amine copolymer
  • Tuberose Panamica extract EDTA Ap ⁇ cot ( Prunus armemaca) kernel oil
  • Vale ⁇ an i Vale ⁇ ana orficinalis ⁇ extract Malic acid Behena ⁇ udopropyl dihvdroxypropyl dimomum
  • Cocamidopropyl dimethylamine C d lactate, C d Hydroxvpropylt ⁇ monium hydrolyzed wheat Proline proptonate protein Propylene glycol stearate Cocamidopropvl dimethvlaminohydroxypropvl Isopropyl hvdroxvbutvramide dimethicone PVP/dimethiconylacrylate/polycarbamyl/ hydrolvzed collagen copolvol polyglvcol ester Cocamidopropvldimomum Isopropvl lanolate PVP/dimethvlam oethylmethacrv late copolymer hvdroxvpropvlhvdrolvzed collagen Isostearamidopropvl betaine.
  • Coco-morpholine oxide Isostearamidopropyl ethvldimomum ethosulfate Quatem ⁇ um-76 hvdrolvzed collagen Coco/oleamidopropvl betaine Isostearamidopropvl laurvlacetodimonium chlo ⁇ de Rapeseedamidopropvl benzvldimonium chlo ⁇ de Cocodimomum hvdroxvpropvl hvdrolvzed hair Isostearamidopropvl morpholine.
  • stearamine Mv ⁇ stamidopropvl beta e.
  • M dimethvlamine Sovamidopropyl betaine S dimethvlamine Dimethvlamidopropvlamuie dimerate Mv ⁇ monium bromide Sovamidopropyl ethvldimomum ethosulfate Disodium hvdrogenated cottonseed glyce ⁇ de Oat (Avena sativa) protein Soyethvl morpholinium ethosulfate sulfosuccmate Oleatmde Soyethvldimomum ethosulfate Disodium laureth sulfosuccmate Oleamidopropvl betaine.
  • N N-dimethvl ammonium chlo Oleamuie oxide Stearamidopropyl ethvldimomum ethosulfate Glutamic acid Oleovl sarcosine Stearamidopropvl morpholine lactate Glvcervl collagenate Olevl betaine Stearamidopropvl PG-dimomum chlo ⁇ de Glv ⁇ ne Olevl dimeihvlamidopropvl ethonium ethosulfate phosphate
  • Salvia miltiorrfuza extract Sodium cocoamphopropionate ⁇ ctoxynol-5. -10
  • Zinc phenol sulfonate Z. ⁇ noleate Sodium C12-15 pareth-25 sulfate Oleth-40
  • Acetvlated mo ⁇ oelyce ⁇ des Colloidal oatmeal Dimethicone propvlethv le ⁇ edi ⁇ mine behenate
  • Cetostean 1 stearate Cetvl C 12 15 parth carboxvlate Cetvl acetate C alcohol Cetvl esters C lactate Cetvl mv nstatc C octanoate Cetvl oleate C p ⁇ lmu ⁇ te Cetvl PPG 2 isodeceth " .. ⁇ rboxv l ⁇ te Cetv I ⁇ L nole ⁇ ie C -.t- ⁇ r ⁇ ie
  • Ethvl li ⁇ olenaie Ethvl li ⁇ olenaie.
  • E minkate Isopentyldiol Octyldodecvl behenate, 0 benzoate
  • Ethyl oleate E oiivate Isopropyl C12-15-pareth-9- arboxylate Octyldodecvl oleate, O ncinoleate
  • Glycereth-7 benzoate Isopropyl PPG-2- ⁇ sodeceth-7 carboxvlate Oleamtne oxide
  • Glycereth-7 dnsononanoate Isopropyl stearate Oleic/palmitoieic/linoleic glvcendes
  • Glycerol tncaprvlate/caprate Isostearyl behenate.
  • Glyceryl adipate Isostearyl diglycervl suc ⁇ nate Orange (Citrus aurantium dulcis) peel wax
  • Glyceryl isostearate G lanolate Isostearvl emcate, I erucvl erucate Orange roughy (Hoplostethus adanticus) od
  • Hybnd safflower (Carthamus tmctonus) oil Lanolin wax PEG-6
  • Isobutvl palmitate I stearate Neem (Meha azadirachta) seed od Pentaervthnrvl isostearate/caprate/caprvlate/adipate
  • Isocetvl behenate I octanoate Neope ⁇ tvl glycol dicaprate Pentaeryth ⁇ tvl stearate Isocetvl palmitate.
  • Poloxamer 105 benzoate PPG- 10 butanediol.
  • PPG-2-buteth-3 PPG-50 cetvl ether.
  • P olevl ether Sorbitan isostearate. S. palmitate
  • PPG-5-laureth-5 Propylene glycol diisostearate.
  • PPG-5 pentaervth ⁇ tvl ether Propylene glycol isostearate. P.g. laurate Steanc acid. S. hydrazide
  • T ⁇ decyl behenate T. cocoate Cet ⁇ m ⁇ nium chlo ⁇ de Glyceryl my ⁇ state. G. oleate
  • T decyl erucate.
  • T ⁇ octyldodecvl curate Decaglycerol monodioleate Hydrogenated soy glvcende
  • Emulsifier Diethvlaminoethvl stearate Isoceted ⁇ -10 stearate
  • Palm acid PEG- 12 dilaurate.
  • PEG-2 cocamine P. distearate PEG-12 laurate, P. oleate PEG-60 hydrogenated castor oil isostearate
  • PEG-2 laurate SE PEG-14 avocado glvcendes PEG-60 shea butter glvcendes
  • PEG-2 oleamine PEG-2 oleamine.
  • P. oleate PEG- 15 castor oil
  • PEG-2 stearate PEG-2 stearate.
  • P. stearate SE PEG- 15 glyceryl isostearate PEG-75
  • PEG-3 C12-C18 alcohols PEG-15 glyceryl ncinoleate PEG-75 dioleate.
  • PEG-3 lanolate PEG-3 lanolate.
  • P. sorbitan oleate PEG- 15 tallow polvami ⁇ e PEG-75 shorea butter glycendes
  • PEG -4 dioleate PEG -4 dioleate.
  • P. diisostearate PEG- 16 hydrogenated castor oil
  • PEG-80 sorbitan laurate
  • PEG-4 dilaurate PEG-4 dilaurate.
  • PEG-16 soy sterol PEG-90 stearate
  • PEG-4 stearate PEG-20 castor oil PEG-4 stearate PEG-20 castor oil.
  • P. dilaurate PEG- 100 lanolin.
  • P. stearate PEG-4 stearate
  • PEG-4 tallate PEG-20 glyceryl laurate PEG-150 dilaurate.
  • PEG-5 castor oil PEG-20 glyceryl oleate PEG- 150 distearate.
  • PEG-5 C12-C18 alcohols PEG-20 glyceryl stearate PEG-150 laurate.
  • Poloxamer 101 ⁇ . 122. 123,124 Sodium nonoxynol- ⁇ phosphate Tissue extract
  • Poloxamer 2 3 8. 33-*. 338,407 Sodium oleate Trideceth-3. -5, -6. -7, -8
  • Sorbitan t ⁇ oleate S. t ⁇ stearate Fermented vegetable
  • Polyglyceryl- 10 disicarate P. isostearate Stearamine oxide Brassica rapa-depressa extract

Abstract

A cosmetic composition is described having a cosmetically acceptable carrier, comprising a reverse thermal viscosifying polymer network comprising at least one poloxamer component capable of aggregation in response to a change in temperature randomly bonded to at least one poly(acrylic acid) component; and a cosmetically active agent which imparts a preselected cosmetic effect, said carrier and said agent disposed within an aqueous-based medium.

Description

COMPOSITIONS FOR COSMETIC APPLICATIONS
This application is a continuation-in-part application of copending application U.S.S.N. 60/034,805 filed January 2, 1997, and entitled "Responsive Polymer
Networks and Methods of Their Use", which is a continuation-in-part application of copending application PCT/US 96/ 10376 filed June 14, 1996, designating the United States, and entitled "Responsive Polymer Networks and Methods of Their Use", which is a continuation-in-part application of copending application U.S.S.N. 08/580,986 filed January 3, 1996, and entitled "Responsive Polymer Networks and Methods of Their Use", each of which is incorporated entirely by reference.
Field of the Invention
The present invention relates to a cosmetic composition useful in a variety of topical and personal care products, including treatments of disorders and imperfections of the skin or oώer areas of the body. More particularly, the present invention is directed to a cosmetic composition comprising a poloxamer:poly(acrylic acid) polymer network that can be designed to reversibly gel over a wide range of conditions to provide a composition having a controllable range of viscosities, making it useful in a variety of cosmetic and personal care applications.
Background of the Invention
Many examples are known of cosmetic compositions intended for treatment of the skin or elsewhere on the body, where it is desired to have certain properties of viscosity. Hydrogels, such as cellulosics, have been included as thickeners in cosmetic compositions. A hydrogel is a polymer network which absorbs a large quantity of water without the polymer dissolving in water. The hydrophilic areas of the polymer chain absorb water and form a gel region. The extent of gelation depends upon the volume of the solution which the gel region occupies. Reversibly gelling solutions are known in which the solution viscosity increases and decreases with an increase and decrease in temperature, respectively. Such reversibly gelling systems are useful wherever it is desirable to handle a material in a fluid state, but performance is preferably in a gelled or more viscous state.
A known material with these properties is a thermal setting gel using block copolymer polyols, available commercially as Pluronic® polyols (BASF,
Ludwigshafen, Germany), which is described in U.S. Patent No. 4,188,373. Adjusting the concentration of the polymer gives the desired liquid-gel transition. However, concentrations of the polyol polymer of at least 18-20 % by weight are needed to produce a composition which exhibits such a transition at commercially or physiologically useful temperatures. Also, solutions containing 18-20 % by weight of responsive polymer are typically very viscous even in the "liquid" phase, so that these solutions can not function under conditions where low viscosit} , free-flowing is required prior to transition. In addition, these polymer concentrations are so high that the material itself may cause unfavorable interactions during use. Another known system which is liquid at room temperature, but forms a semi- solid when warmed to about body temperature is formed from tetrafunctional block polymers of polyoxyethylene and polyoxypropylene condensed with ethylenediamine. commercially available as Tetronic® polyols. These compositions are formed from approximately 10% to 50% by weight of the polyol in an aqueous medium. See, U.S. Patent No. 5,252.318.
Joshi et al. in U.S. Patent No. 5.252.318 reports reversible gelling compositions which are made up of a physical blend of a pH-sensitive gelling polymer (such as a cross-linked poly(acrylic acid) and a temperature-sensitive gelling polymer (such as methyl cellulose or block copolymers of poly(ethylene glycol) and poly(propylene glycol)). In compositions including methylcellulose, 5- to 8-fold increases in viscosity are observed upon a simultaneous change in temperature and pH for very low methylcellulose levels (1-4% by weight). See, Figs. 1 and 2 of Joshi et al. In compositions including Pluronic® and Tetronic® polyols, commercially available forms of poly(ethylene glycol)/poly(propylene glycol) block copolymers, significant increases in viscosity (5- to 8-fold) upon a simultaneous change in temperature and pH are observed only at much higher polymer levels. See, Figs. 3-6 of Joshi et al.
Hoffman et al. in WO 95/24430 disclose block and graft copolymers comprising a pH-sensitive polymer component and a temperature-sensitive polymer component. The block and graft copolymers are well-ordered and contain regularly repeating units of the pH-sensitive and temperature-sensitive polymer components. The copolymers are described as having a lower critical solution temperature (LCST), at which both solution-to-gel transition and precipitation phase transition occur. Thus, the transition to a gel is accompanied by the clouding and opacification of the solution. Light transmission is reduced, which may be undesirable in many applications, where the aesthetic characteristics of the composition are of some concern.
Thus, the known systems which exhibit reversible gelation art limited in that they require large solids content and/or in that the increase in viscosity less than 10- fold. In addition, some known systems exhibit an increase in viscosity which is accompanied with the undesirable opacification of the composite.
Summary of the Invention It is an object of the present invention to provide a cosmetic composition which is includes a component capable of reversible gelation or viscosification.
It is a further object of the invention to provide a cosmetic composition which includes an ingredient capable of gelation or viscosification at very low solids content. It is another object of the present invention to provide a cosmetic composition which possesses improved flow and gelation characteristics as compared to properties possessed by conventional reversible gelation compositions.
It is a further object of the invention to provide a polymer network composition for use in cosmetic compositions useful as a surfactant or emulsifier in the solubilization of additives and, in particular, hydrophobic additives.
It is a further object of the invention to provide a cosmetic composition which possesses the appropriate thickness, emolliency and cosmetic effect with a minimum of solids content. It is a further object of the invention to provide a polymer network for use in cosmetic compositions useful as a suspending agent for otherwise insoluble additives.
It is yet a further object of the present invention to provide a composition capable of solubilizing emulsions at elevated temperatures.
It is yet a further object of the invention to provide new and useful cosmetic compositions incorporating the reversibly gelling polymer network composition of the present invention, which take advantage of its unique advantageous properties.
It is yet another object of the present invention to provide reversibly gelling polymer network compositions which are composed of biocompatible polymers.
These and other objects of me invention are achieved with a cosmetic composition which incorporates a poloxamer:poly(acrylic acid) polymer network as a cosmetically acceptable carrier. The polymer network comprises a poloxamer component randomly bonded to a poly(acrylic acid), or PAA. component in an aqueous-based medium, the polymer network being capable of aggregating in response to an increase in temperature. The reverse thermal viscosifying poloxamer:poly(acrylic acid) polymer network includes random covalent bonding between the poly(acrylic acid) component and the poloxamer component of the network. The polymer network may also include some unbound or "free" poloxamer or other additives which contribute to or modify the characteristic properties of the polymer composition. In addition, the cosmetic composition includes a cosmetic agent selected to provide a preselected cosmetic effect. By "cosmetic agent", as that term is used herein, it is meant that the additive imparts a cosmetic effect. A cosmetic effect is distinguishable from a pharmaceutical effect in that a cosmetic effect relates to the promoting bodily attractiveness or masking the physical manifestations of a disorder or disease. In contrast, a pharmaceutic seeks to treat the source or symptom of a disease or physical disorder. It is noted however, that the same additives may have either a cosmetic or pharmaceutical effect, depending upon the amounts used and die manner of administration.
Bv "cosmetic" as that term is used herein, it is meant the cosmetic and personal-care applications intended to promote bodily attractiveness or to cover or mask the physical manifestations of a disorder or disease. Cosmetics include those products subject to regulation under the FDA cosmetic guidelines, as well as sunscreen products, acne products, skin protectant products, anti-dandruff products, and deodorant and antiperspirant products.
By "gelation" or viscosification, as that term is used herein, it is meant a drastic increase in the viscosity of the polymer network solution. Gelation is dependent on the initial viscosity of the solution, but typically a viscosity increase in the range of preferably 2- to 100-fold, and preferably 5- to 50-fold, and more preferably 10- to 20- fold is observed in the polymer network which is used in d e preparation of the cosmetic compositions of the invention. Such effects are observed in a simple polymer network solution and the effect may De modified by the presence of other components in the cosmetic composition.
By "reversibly gelling" as that term is used herein, it is meant that the process of gelation takes place upon an increase in temperature rather than a decrease in temperature. This is counter-intuitive, since it is generally known that solution viscosity decreases with an increase in temperature.
As used herein, "poloxamer" is a triblock copolymer derived from poIy(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol) blocks. The poloxamer is capable of responding to a change in temperature by altering its degree of association and/or agglomeration. The aggregation may be in the form of micelle formation, precipitation, labile crosslinking or other factors. The poloxamer has d e general formula of a triad ABA block copolymer, (P^P^P ι)» where P , = poly(ethylene glycol) and P2 = poly(propylene glycol) blocks, where a is in the range of 10-50 and where b is in the range of 50-70.
The poly(acrylic acid) component includes poly(acrylic acid) and its salts. The poly(acrylic acid) supports and interacts with the poloxamer component so that a multi-material, responsive polymer network is formed. The interaction of the poloxamer and poly(acrylic acid) exhibits a synergistic effect, which magnifies the effect of the poloxamer component in viscosifying and/or gelling the solution. The novel interaction between the constituent polymers components of the polymer network permits formation of gels at very low solids content. Gelation and/or viscosification is observed in aqueous solutions having about 0.01 to 20 wt% of the poloxamer component and about 0.01 to 20 wt% of the poly(acrylic acid) component. A typical reversibly gelling polymer network may be comprised of less than about 4 wt% of total polymer solids (e.g., poloxamer and poly(acrylic acid))and even less dian lwt% total polymer solids while still exhibiting reverse thermal viscosification. Of course, d e total solids content including additives of a reversibly gelling polymer network composition may be much higher. The viscosity of the gel increases at least ten-fold with an increase in temperature of about 5°C at pH 7 and 1 wt% polymer. Viscosity increases may be even greater over a larger temperature range at pH 7 and 1% polymer network content.
The relative proportion of poloxamer and poly(acrylic acid) may vary dependent upon the desired properties of the polymer composition. In one embodiment, the poloxamer is present in a range of about 1 to 20 wt% and the poly(acrylic acid) is present in a range about of 99 to 80 wt%. In another embodiment, the poloxamer component is present in a range of about 21 to 40 wt% and the poly(acrylic acid) component is present in a range of about 79 to 60 wt%. In another embodiment, the poloxamer component is present in a range of about 41 to 50 wt% and the poly(acrylic acid) component is present in a range of about 59 to 50 wt%. In another embodiment, the poloxamer component is present in a range of about 51 to 60 wt% and the poly(acrylic acid) component is present in a range of about 49 to 40 wt%. In yet another embodiment, me poloxamer component is present in a range of about 61 to 90 wt% and the poly(acrylic acid) component is present in a range of about 39 to 20 wt%. In anomer embodiment, d e poloxamer component is present in a range of about 81 to 99 wt% and me poly(acrylic acid) component is present in a range of about 19 to 1 wτ%.
The poloxameπpoly(acrylic acid) polymer network described above is included in a cosmetic composition to improve the flow characteristics, thickness and other properties of the composition. The composition includes additional cosmetic agents. such as are needed for the cosmetic purpose of the composition. Additives also may be included to modify die polymer network performance, such as to increase or decrease the temperature of the liquid-to-gel transition and/or to increase or decrease the viscosity of the responsive polymer composition. In one aspect of the invention, the poloxamer:poly(acrylic acid) polymer network is incorporated into a cosmetic compositions to impart thickening properties to the cosmetic composition at the use and/or application temperature. Such thickening properties include enhanced overall viscosity, as well as a desirable viscosity response with temperature. The polymer network may be useful as a diickener in pH ranges where other thickeners are not effective.
In another aspect of the invention, the poloxamer:poly(acrylic acid) polymer network is incorporated into a cosmetic composition to stabilize and solubilize hydrophobic agents in the cosmetic composition. The polymer network may be included to increase emulsion stability. Many emulsions, i.e.. suspension of small droplets or particles of a first material in a second material, lose viscosity upon heating. As will be demonstrated herein, the poloxamer:poly(acrylic acid) polymer network retains its emulsifying properties even with temperature increase.
In addition, it may be included in the composition to impart emolliency to the composition. The composition may also act as a film-forming agent after it has been applied to die skin. This film-forming agent may be used as a barrier to prevent water loss from the skin which contributes to the moisturization of the skin.
In another aspect of the invention, the poloxamer:poly(acrylic acid) poiymer network may be included as an additive in cosmetic applications to prevent viscosity loss at elevated temperatures.
Brief Description of the Drawing The invention is described with reference to the Drawing, which is presented for the purpose of illustration and is in no way intended to be limiting, and in which: Figure 1 is a graph of viscosity vs. temperature for a 1 wt%, 2 wt% and 3 wt% responsive polymer network aqueous composition of a poloxamer/poly(acrylic acid) (1 : 1) at pH 7.0 measured at a shear rate of 0.44 sec"1;
Figure 2 is a graph of viscosity vs. temperature for a 1 wt% poloxamer: poly(acrylic acid) polymer network composition demonstrating reversibility of the viscosity response; Figure 3 shows die viscosity response of a 2 wt% poloxamer:poly(acrylic acid) polymer composition at various shear rates;
Figure 4 shows a viscosity response curve for a 2 wt% poloxamer: poly(acrylic acid) polymer network composition prepared wim nominal mixing and stirring and prepared using high shear homogenization (8000 rpm, 30 min); Figure 5 is a graph of viscosity vs. temperature for a 1 wt% poloxamer: poly(acrylic acid) polymer network composition at various pHs;
Figure 6 is a graph of viscosity vs. temperature for a 1 wt% poloxamer: poly(acrylic acid) polymer network composition with and without addition ol 0.25 wt% KC1; Figure 7 is a graph of viscosity vs. temperature for a 1 wt% poloxamer: poly(acrylic acid) polymer network composition with and without addition of 0.5 wt% acetamide MEA;
Figure 8 is a graph of viscosity vs. temperature for a 1 wt% poloxamer: poly(acrylic acid) polymer network composition wi out and with 5 wt%, 10 wt% and 20 wt% added ethanol, respectively;
Figure 9 is an illustration of a reversibly gelling polymer network used as an emuisifier and stabilizer for a hydrophobic agent;
Figure 10 is a schematic illustration of me poloxamer:poly(acrylic acid) polymer network below and above the transition temperature illustrating die aggregation of the hydrophobic poloxamer regions;
Figure 1 1 is a graph of viscosity vs. pH for a 1 wt% responsive polymer network aqueous composition of a poloxamer/poly(acrylic acid) (1 :1) measured at a shear rate of 0.44 sec"1;
Figure 12 is a plot of viscosity vs. temperature for (a) a 1 wt% responsive polymer network aqueous composition of Pluronic® F127 poloxamer/poly(acrylic acid) (1 : 1) and (b) a 1 wt% physical blend of Pluronic® F127 poloxamer/poly(acrylic acid) (1 : 1) at pH 7.0 measured at a shear rate 0.22 sec"1;
Figure 13 is a plot of viscosity vs. temperature for a 1 wt% responsive polymer network aqueous composition of Pluronic® F88 poloxamer/poly(acrylic acid) (1 : 1) at pH 7.0 measured at a shear rate 2.64 sec"';
Figure 14 is a graph of the viscosity vs. temperature effect for a responsive polymer network composition of 2 wt% Pluronic® PI 04 poloxamer/poly(acrylic acid) (1 : 1) in deionized water at pH 7.0 measured at shear rate of 22 sec"1;
Figure 15 is plot of viscosity vs. temperature for a responsive polymer network composition of 2 wτ% Pluronic® F123 poloxamer/poly(acrylic acid) (1 : 1) at pH 7.0 measured at a shear rate of 22 sec"':
Figure 16 is a plot of viscosity vs. temperature for 1 wt% made of series of poloxamers and poly(acrylic acid) (1 : 1) in deionized water at a shear rate of 132 sec'1;
Figure 17 is a plot showing release of hemoglobin from a poloxamer/poly(acrylic acid) polymer network of the invention;
Figure 18 is a plot showing the release of lysozyme from the poloxamer/poly(acrylic acid) polymer complex of the invention:
Figure 19 is a plot showing release of insulin from a poloxamer/poly(acrylic acid) polymer network composition of the invention: Figure 20 is a plot of viscosity vs. temperature for a poloxamer/poly(acrylic acid) polymer network composition (a) before and (b) after sterilization by autoclave;
Figure 21 is a plot of viscosity vs. temperature for an oil-free moisturizing formulation prepared from (a) a responsive polymer network composition of the invention and (b) a conventional oil-in-water formulation; Figure 22 is a plot of equilibrium solubility of estradiol (A, B) and progesterone (C, D) in aqueous solutions (pH 7) of Pluronic® F127 (A, C) and responsive polymer network (B, D) vs. temperature;
Figure 23 is a plot of the ratio of equilibrium solubilities of estradiol in responsive polymer network and water vs. polymer concentration in the responsive polymer network solutions; Figure 24 is a plot of the effect of loading fluorescein on the onset of gelation of responsive polymer network vs. total polymer concentration in responsive polymer network solution (pH 7.0);
Figure 25 is a plot of die percentage of a) estradiol and b) progesterone release from responsive polymer network vs. time;
Figure 26 is a plot of the rate of progesterone release and macroscopic viscosity vs. polymer concentration;
Figure 27 is a plot of the percentage of progesterone release vs. polymer concentration in responsive polymer network and, Figure 28 is a plot of the relative diffusivity of poly(styrene) latex panicles in water and responsive polymer network.
Detailed Description of the Invention
The present invention is directed to a cosmetic composition comprising a cosmetically acceptable carrier comprising a novel poloxamer:poly acrylic acid) polymer network. The polymer network functions as a temperature sensitive thickening agent, and in addition possesses surfactant and emulsifying capabilities which may be beneficial to the cosmetic composition. The polymer network composition according to the invention includes a poloxamer component randomly bonded to a poly(acrylic acid) component. The two polymer components may interact with one another on a molecular level. The polymer network contains about 0.01-20 wt% each of poloxamer and poly(acrylic acid). Exemplary polymer network- compositions range from about 1 : 10 to about 10:1 poloxamer:poly(acrylic acid). Polymer network gel compositions which exhibit a reversible gelation at body temperature (25-40°C) and or at physiological pH (ca. pH 3.0-9 0) and even in basic environments up to pH 13 (hair care) are particularly preferred for cosmetic applications.
In one embodiment of the invention, a 1 : 1 poloxamer:poly(acrylic acid) polymer network at appropriate pH exhibits flow properties of a liquid at about room temperature, yet rapidly thickens into a gel consistency of at least about five times greater, preferably at least about 10 times greater, and even more preferably at least about 30 times and up to 100 times greater, viscosity upon increase in temperature of about 10 °C and preferably about 5 °C. The reversibly gelling polymer network of the present invention exhibit gelation even at very low polymer concentrations. For example, polymer network compositions at pH 7 comprising about 0.5 wt% poloxamer component and about 0.5 wt% PAA exhibits a significant increase in viscosity from a free-flowing liquid (50 cps) to a gel (6000 cps). The observed gelation takes place at low solids contents, such as less tiian 20 wt% or preferably less than about 10 wt%, or more preferably less than about 2.5 wt% or most preferably less than about 0.1 wt%. Thus, only a small amount by weight of the polymer network need be incorporated into a cosmetic composition in order to provide me desired thickening or viscosifying effect.
The reverse viscosification effect at low polymer concentrations provides clear, colorless gels which are particularly well-suited to cosmetic applications. For example, very little residue is formed upon dehydration which may be important in some applications, such as in topically applied cosmetics. An additional advantage of d e polymer network of the invention is that it remains clear and translucent above and below the critical temperature or pH. These characteristics of me reversibly gelling polymer network make it well suited for use in cosmetic compositions. The polymer network of the present invention technology may be added to cosmetic formulations to increase the diickness and viscosity of die composition. The poloxamer:poly(acrylic acid) polymer network possesses hydrophobic regions capable of aggregation. Unlike conventional thickeners, the aggregation of the polymer network of the present invention is temperature sensitive. Thus, die inventive polymer network of the present invention may have a transition temperature (i.e. temperature of aggregation) above room temperature so that die cosmetic composition is of low viscosity at or below room temperature and is of high viscosity at or around body temperature (body temperature includes both surface and internal body temperature). Thus, a composition may be prepared at low temperatures while the polymer network is in a low viscosity state. Mixing of ingredients under low viscosity is expected to be easier, thus simplifying the manufacturing process. Yet, the resultant mixture would be of increased viscosity at use temperatures. As a further advantage, a cosmetic composition comprising poloxamer:poly(acrylic acid) polymer network may be spread ti inly to allow for even application, due to its low viscosity at room temperature, but will thicken and "fill" the skin contours upon warming up to body surface temperature. In another aspect of die invention, d e composition may be applied d rough a nozzle d at provides high shear to reduce viscosity, yet the composition regains its viscosity after application to d e skin. This contrasts with conventional formulations which permanently lose viscosity after being subjected to high shear. In another aspect of die invention, the composition may be formulated and applied as a liquid, spray, semi-solid gel, cream, ointment, lotion, stick, roll-on formulation, mousse, pad-applied formulation, and film-forming formulation.
The poloxamer:poly(acrylic acid) polymer network may also be included in a cosmetic composition for use as a stabilizing, solubilizing or emulsifying agent for a hydrophobic component of the cosmetic formulation. The strong hydrophilic regions of the poloxamer resulting from aggregation and micelle formation create hydrophobic domains which may be used to solubilize and control release of hydrophobic agents. Similar micelle-based systems have been shown to protect trapped peptides against enzymatic degradation from surface enzymes. The reversibly gelling polymer network of the present invention is a unique polymer composition designed to abruptly change its physical characteristics or the characteristics and properties of materials mixed d erewith with a change in temperature. Without intending to be bound by any particular mechanism or chemical structure, it is believed that d e structure of the polymer network involves a random bonding of die poloxamer onto the backbone of die poly(acrylic acid). A portion of the poloxamer which is present during d e polymerization reaction which forms the poly(acrylic acid) is bonded to the backbone of the forming poly(acrylic acid) dirough hydrogen abstraction and subsequent reaction. See detailed discussion of die mechanism, below. The combination of the poly(acrylic acid) and randomly bonded poloxamer gives the composition its unique properties. Any free poloxamer remaining after polymerization of PAA remains associated with the random co-polymer, resulting in a miscible composition. Free poloxamer may also be present in the polymer network composition; however, its presence is not required in order to observe reverse thermal viscosification. The poly(acrylic acid) may be linear, branched and/or crosslinked. Poly(acrylic acid) is capable of ionization with a change in pH of the solution. By ionization, as tiiat term is used witii respect to poly(acrylic acid), it is meant the formation of d e conjugate base of the acrylic acid, namely acrylate. As used herein, poly(acrylic acid) includes both ionized and non-ionized versions of me polymer. Changes in ionic strength may be accomplished by a change in pH or by a change in salt concentration. The viscosifying effect of the polymer network is partly a function of the ionization of d e poly(acrylic acid); however, reverse thermal gelling may occur without ionization. Changes to the ionic state of the polymer causes the polymer to experience attractive (collapsing) or repulsive (expanding) forces. Where there is no need or desire for the composition to be applied in a high viscosity state, it may be possible to prepare the composition as non-ionized poly(acrylic acid). The body's natural buffering ability will adjust the pH of the applied composition to ionize the poly(acrylic acid) and diereby develop its characteristic viscosity.
The poloxamer possesses regions of hydrophobic character, e.g., polypropylene glycol) blocks, and hydrophilic character, e.g.. poiy(ethylene glycol) blocks. The poloxamer may be linear or branched. Suitable poloxamers include triad block copolymers of poly(ethylene glycol) and poly(propylene glycol) having the general formula (P|)a(P2)b(P1)a, where P, = poly(ethylene glycol) and P: = poly(propylene glycol) blocks, where a is in the range of 10-50 and where b is in d e range of 50-70. where poly(propylene glycol) represents the hydrophobic portion of the polymer and poly(etirylene glycol) represents the hydrophilic portion of die polymer. Pluronic® polymers (BASF) are commercially available for a in the range of 16 to 48 and b ranging from 54-62. One or more poloxamers may be used in die reversibly gelling polymer network composition of the present invention. The reversibly gelling responsive polymer networks compositions of me present invention are highly stable and do not exhibit any phase separation upon standing or upon repeated cycling between a liquid and a gel state. Samples have stood at room temperature for more than three months without any noticeable decomposition, clouding, phase separation or degradation of gelation properties. This is in direct contrast to polymer blends and aqueous mixed polymer solutions, where phase stability and phase separation is a problem, particularly where the constituent polymers are immiscible in one anotiier.
An example of the dramatic increase in viscosity and of d e gelation of the reversibly gelling polymer network compositions of the invention is shown in Figure 1. Figure 1 is a graph of viscosity vs. temperature for 1 wt%, 2 wt% and 3 wt% polymer network compositions comprising 1 : 1 poloxamer:poly(acrylic acid), hydrated and neutralized. The viscosity measurements were taken on a Broυkfield viscometer at a shear rate of 0.44 sec"' at pH 7.0. All solutions had an initial viscosity of about 1080 cP and exhibited a dramatic increase in viscosity to gel point at about 35°C. This is not typical of all polymer network compositions since polymerization condition will affect initial viscosity. Final viscosities were approximately 33,000 cP, 100,000 cP and 155,000 cP for the 1 wt%, 2 wt% and 3 wt% compositions, respectively. This represents viscosity increases of about 30-. 90- and 140-fold, respectively. This effect is entirely reversible. Upon cooling, the composition regains its initial viscosity. This is demonstrated in Figure 2. where a 1 wt% poloxamer:poly(acrylic acid) composition is warmed dirough the transition temperature up to 35 "C (simple curve), cooled to room temperature (24 °C, ticked curve) and then warmed again to up above the transition temperature (open box curve). The viscosity response was virtually identical in all three instances. As would be expected with a non-Newtonian system, the solution viscosity differs with different shear rates. Figure 3 shows d e viscosity response of a 2 wt% poloxamer:poly(acrylic acid) polymer composition at various shear rates. The viscosity response is consistent between 24 *C and 34 "C; however, the final viscosity is reduced witii increasing shear rate. However, unlike many prior art hydrogels, e.g., carbomers, d e poloxamer:poly(acrylic acid) polymer network composition does not permanently loose viscosity after being subjected to high shear conditions. The poloxamer:poly(acrylic acid) polymer network composition remains unaffected by such shear conditions as homogenization. Figure 4 compares die viscosity response curve of a 2 wt% poloxamer:poly(acrylic acid) polymer composition prepared with nominal mixing (simple lime) and stirring with that of a polymer composition of similar composition prepared using high shear homogenization designated by a ticked line (8000 rpm, 30 min). No significant decrease in viscosity is observed.
A number of factors influence me viscosity and transition temperature of the composition. The more important factors include polymer concentration. pH and presence and nature of additives.
The effect of pH on d e viscosity of reversibly gelling polymer networks is shown in Figure 5. Increasing pH from the starting pH has a lesser effect on the viscosity than decreasing the pH. This may relate to the extent of ionization of the poly(acrylic acid) component of the polymer network as discussed above. This may be clearly seen in Figure 5 when comparing the viscosity response of a 1 wt% poloxamer:poly(acrylic acid) polymer composition at pH 5 and pH 11. Satisfactory viscosities can be obtained at high pHs indicating the potential value of d e reversibly gelling polymer network in products such as depilatories, hair straighteners and hair relaxers.
The responsive polymer network may also include additives for influencing die performance of the polymer composition, such as the transition temperature and the viscosity of the polymer composition above me transition temperature. The following list is not intended to be exhaustive but rather illustrative of the broad variety of additives which can be used.
These materials include solvents (e.g., 2-propanol, ethanol, acetone, 1,2- pyrrolidinone, N-methylpyrrolidinone), salts (e.g., calcium chloride, sodium chloride, potassium chloride, sodium or potassium phosphates, borate buffers, sodium citrate), preservatives (benzalkonium chloride, phenoxyethanol, sodium hydroxymediylglycinate. ethylparaben. benzoyl alcohol, methylparaben, propylparaben. butylparaben, Germaben II), humectant/moisturizers (acetamide MEA, lactimide MEA, hydrolyzed collagen, mannitol, pandienol, glycerin), lubricants (hyaluronic acid, mineral oil, PEG-60-lanolin, PPG-12-PEG-50-lanolin, PPG-2 myristyl ether propionate) and surfactants. Surfactants may be divided into tiiree classes: cationic, anionic, and nonionics.
An example of a cationic surfactant used is ricinoleamidopropyl ethyldimonium ed osulfate (Lipoquat R). Anionic surfactants include sodium dodecyl sulfate and etiier sulfates such as Rhodapex CO-436. Nonionic surfactants include Surfynol CT-111, TG, polyoxyediylene sorbitan fatty acid esters such as Tween 65 and 80, sorbitan fatty acid esters such as Span 65, alkylphenol ethoxylates such as Igepal CO-210 and 430, dimethicone copolyols such as Dow Corning 190, 193, and Silwet L7001.
The addition of polymers has been studied including xanthan gum. cellulosics such as hydroxyethylcellulose (HEC), carbomethoxycellulose (CMC), lauryldimonium hydroxypropyl oxyethyl cellulose (Crodacel QL). hydroxypropylcellul.se (HPC), and hydroxypropylmethylcellulose (HPMC). poly(acrylic acid), cyclodextrins. methyl acrylamido propyl triammonium chloride (MAPTAC), polyethylene oxide, polyvinylpyroliddone, polyvinyl alcohol, and propylene oxide/ethylene oxide random copolymers. Poloxamers may also be used as additives. Examples include bodi the Pluronic® polyols having an (P1)a(P:)b(Pι)a structure such as Pluronic® F38. L44. P65, F68. F88. L92, P103. P104. P105. F108. L 122 and F127, as well as the reverse
Pluronic® R series (P:)a(P,)b(Pi)a structure such as Pluronic® 17R2 and 25R8. Other miscellaneous materials include propylene glycol. urea, triethanolamine. alkylphenol etiioxylates (Iconol series), and linear alcohol alkoxylates (Plurafac series).
Additives affect the viscosity of the compositions differently depending upon the nature of the additive and its concentration. Some additives will affect the initial or final viscosity, whereas others will affect d e temperature range of the viscosity response, or both.
Potassium chloride and acetamide MEA are two examples of additives which decrease the final viscosity of the composition (see, Example 30). KC1 (0.25%) added to a 1 wt% reversibly gelling polymer composition reduces the viscosity by about 3000 cps. See, Figure 6. The humectant, acetamide MEA, lowers the viscosity of a 1 wt% solution by approximately 1,500 cps (see, Figure 7).
Glycerin, etiianol and dimetiiicone copolymer have been shown to affect d e temperature range over which the viscosity response occurs. Glycerin shifts the transition temperature to a slightly lower range from an initial 24-34 °C to about 24- 30 °C, but does not affect die final viscosity (see, Example 44). The effect of ethanol on d e viscosity is different at different concentration levels. At 5 wt% and 10 wt% added ethanol, die transition temperature is shifted to lower ranges, e.g., 24-29 °C and 20-29 °C. respectively. At 20 wt% added ethanol. d e composition not only exhibits a lowering of the transition temperature, but also a marked increase in initial and final viscosity. See, Figure 8. Dimethicone copolymer ( 1 wt%) also changed the transition temperature, but in this instance the transition temperature range was raised to 28- 41 °C. Thus, proper selection of additives permits me formulator to adjust d e transition temperature to various ranges. Those skilled in the art will appreciate that the polymer network compositions of the present invention may be utilized for a wide variety of cosmetic and personal care applications. To prepare a cosmetic composition, an effective amount of cosmetically active agent(s) which imparts the desirable cosmetic effect is incorporated into the reversibly gelling polymer network composition of the present invention. Preferably the selected agent is water soluble, which will readily lend itself to a homogeneous dispersion through out the reversibly gelling polymer network composition; however, the polymer network has been demonstrated to significantly solubilize or suspend hydrophilic agents in order to improve formulation homogeneity (see. Example 36). It is also preferred that the agent(s) is nonreactive with the polymer network composition. For materials which are not water soluble, it is also within die scope of the invention to disperse or suspend powders or oil (lipophilic materials) throughout the polymer network composition. It will also be appreciated tiiat some applications may require a sterile environment. It is contemplated as witi in die scope of the invention that the reversibly gelling polymer network compositions of the present invention may be prepared under sterile conditions. .An additional feature of the reversibly gelling polymer composition is mat is prepared from constituent polymers that have known accepted toxicological profiles.
The poloxamer:poly(acrylic acid) polymer network has been evaluated under Good Laboratory Practice (GLP) standard protocols known in the art for toxicity in animal models and found to exhibit no toxic effects. The results of the toxicity study are summarized in the following Table 1. The non-toxicity of the polymer network makes it an ideal candidate for use in cosmetic compositions. Table 1. Toxicity data for 6% poloxamer: poly(acry lie acid) solution at pH 7.
Exemplary cosmetic and personal care applications, for which the reversibly gelling polymer network composition may be used include, but are not limited to, baby products, such as baby shampoos, lotions, powders and creams: bath preparations, such as bath oils, tablet and salts, bubble baths, bath fragrances and bath capsules; -eye makeup preparations, such as eyebrow pencil, eyeliner, eye shadow, eye lotion, eye makeup remover and mascara; fragrance preparations, such as colognes and toilet waters, powders and sachets; noncoloring hair preparations, such as hair conditioner, hair spray, hair straighteners, permanent waves, rinses shampoos, tonics, dressings and otiier grooming aids; color cosmetics; hair coloring preparations such as hair dye, hair tints, hair shampoos, hair color sprays, hair lighteners and hair bleaches; makeup preparations such as face powders, foundations, leg and body paints, lipstick, makeup bases, rouges and makeup fixatives; manicuring preparations such as basecoats and undercoats, cuticle softeners, nail creams and lotions, nail extenders, nail polish and enamel, and nail polish and enamel remover; oral hygiene products such as dentrifices and mouthwashes; personal cleanliness, such as bath soaps and detergents, deodorants, douches and feminine hygiene product; shaving preparations such as aftershave lotion, beard softeners, men's talcum, shaving cream, shaving soap and preshave lotions; skin care preparations such as cleansing preparations, skin antiseptics, depilatories, face and neck cleansers, body and hand cleansers, foot powders and sprays, moisturizers, night preparations, paste masks, and skin fresheners; and suntan preparations such as suntan creams, gels and lotions, indoor tanning preparations. Preparation of the above-named cosmetic compositions and others may be accomplished with reference to any of the cosmetic formulation guidebooks and industy journals which are available in the cosmetic industry. These references supply standard formulations which may be modified by the addition or substitution of the reversible viscosifying polymer network of the present invention into the formulation. Suitable guidebooks include Cosmetics and Toiletries Magazine. Vol. I l l (March, 1996); Formularv: Ideas for Personal Care; Croda. Inc. Parsippany. NJ (1993); and Cosmeticon: Cosmetic Formulary, BASF, which are hereby incorporated in their entirety by reference.
The cosmetic composition may be in any form. Suitable forms include but are not limited to lotions, creams, sticks, rυll-ons formulations, mousses, aerosol sprays, pad-applied formulations, and film-forming formulations.
As those skilled in the art will appreciate, the foregoing list is exemplary only. Because the reversibly gelling polymer network composition of die present invention is suited for application under a variety of physiological conditions, a wide variety of cosmetically active agents may be incorporated into and administered from the polymer network composition. In addition to die poloxamer:poly(acrylic acid) polymer network, additional cosmetically acceptable carriers may be included in die composition, such as by way of example only, emollients, surfactants, humectants, powders and other solvents. By way of example only, the cosmetic composition also may include additional components, which serve to provide additional aspects of the cosmetic affect or to improve the stability and/or administration of the cosmetic. Such additional components include, but are not limited to, preservatives, abrasives, acidulents, antiacne agents, anti-aging agents, antibacterials, anticaking, anticaries agents, anticellulites, antidandruff, antifungal, anti-inflammatories, anti-irritants, antimicrobials, antioxidants, astringents, anitperspirants, antiseptics, antistatic agents, astringents, binders, buffers, additional carriers, chelators, cell stimulants, cleansing agents, conditioners, deodorants, dipilatories, detergents, dispersants, emollients, emulsifiers, enzymes, essential oils, exfoliants, fibers, film forming agents, fixatives, foaming agents, foam stabilizers, foam boosters, fungicides, gellants, glosser. hair conditioner, hair set resins, hair sheen agents, hair waving agents, humectants. lubricants, moisture barrier agents, moisturizers, ointment bases, opacifier. plasticizer. polish, polymers, powders, propellant, protein, refatting agents, sequestrant, silicones. skin calming agents, skin cleansers, skin conditioners, skin healing, skin lightening agents, skin protectants, skin smoothing agents, skin softening agents, skin soothing agents, stabilizers, sunscreen agents, surfactants, suspending agents, tanning accelerators, thickeners, vitamins, waxes, wetting agents, liquefiers. colors, flavors and/or fragrances . Suitable materials which serve the additive functions listed here are well known in the cosmetic industry. A listing of the additive function and materials suitable for incorporation into the cosmetic composition may be found in Appendix A, which is appended hereto at d e end of the specification. Further information may be obtained by reference to The Cosmetic Bench Handbook. Cosmetics & Toiletries; C.C. Urbano, editor. Allured Publ. Corp., 1996, which is hereby incorporated in its entirety by reference.
A brief description of some preferred additives and cosmetically active agents follows. The compositions of the invention include a safe and effective amount of a cosmetically active agent. "Safe and effective", as it is used herein, means an amount high enough to significantly positively modify the condition to be treated or the cosmetic effect to be obtained, but low enough to avoid serious side effects.
Preservatives can be desirably incorporated into the cosmetic compositions of die invention to protect against the growth of potentially harmful microorganisms. Suitable preservatives include, but are not limited to, alkyl esters of para- hydroxybenzoic acid, hydantoin derivatives, parabens, propioniate salts, triclosan tricarbanilide, tea tree oil, alcohols, farnesol, farnesol acetate, hexachlorophene and quaternary ammonium salts, such as benzoiconjure, and a variety of zinc and aluminum salts. Cosmetic chemists are familiar with appropriate preservatives and may selects that which provides die required product stability. Preservatives are preferably employed in amounts ranging from about 0.0001% to 2% by weight of the composition.
Emollients can be desirably incorporated into the cosmetic compositions of die invention to provide lubricity to the formulation. Suitable emollients may be in the form of volatile and nonvolatile silicone oil. highly branched hydrocarbons and synti etic esters. Amounts of emollients may be in the range of about 0.1-30 wt%, and preferably about 1-20 wt%. By way of example only, suitable silicones include cyclic or linear pol dimethylsiloxanes, polyalkylsiloxanes, polyalkylarylsiloxanes and polyether siloxanes. By way of example only, suitable ester emollients include alkenyl esters of fatty acids, polyhydric alcohols, such as ethylene glycol mono and di-fatty acid esters, polyethylene glycol and the like, ether-esters, such as fatty acid esters of ethoxylated fatty alcohols, wax esters, such as beeswax, spermaceti, mysristyl myristate and stearyl stearate. and sterol esters, such as cholesterol fatty acids. A variety of oily emollients may be employed in the compositions of this invention. These emollients may be selected from one or more of the following classes: 1. Triglyceride esters such as vegetable and animal fats and oils. Examples include castor oil. cocoa butter, safflower oil, cottonseed oil. corn oil, olive oil, cod liver oil, almond oil, avocado oil, palm oil, sesame oil, squalene. Kikui oil and soybean oil; 2. Acetoglyceride esters, such as acetylated monoglycerides; 3.
Ethoxylated glycerides. such as ethoxylated glyceryl monostearate: 4. Alkyl esters of fatty acids having 10 to 20 carbon atoms, such as. methyl, isopropyl, and butyl esters of fatty acids, and including hexyl laurate, isohexyl laurate, isohexyl palmitate, isopropyl palmitate, decyl oleate, isodecyl oleate, hexadecyl stearate decyl stearate, isopropyl isostearate, diisopropyl adipate. diisohexvl adipate. dihexyldecyl adipate, diisopropyl sebacate, lauryl lactate, myristyl lactate, and cetyl lactate; 5. alkenyl esters of fatty acids having 10 to 20 carbon atoms, such as oleyl myristate, oleyl stearate, and oleyl oleate and the like; 6. fatty acids having 10 to 20 carbon atoms, such as pelargonic, lauric, myristic, palmitic, stearic, isostearic, hydroxystearic, oleic, linoleic, ricinoleic, arachidic, behenic, and erucic acids and die like; 7. fatty alcohols having 10 to 20 carbon atoms, such as, lauryl, myristyl, cetyl, hexadecyl, stearyl, isostearyl, hydroxystearyl, oleyl, ricinoleyl, behenyl, erucyl, and 2-octyl dodecanyl alcohols are examples of satisfactory fatty alcohols and d e like, 8. fatty alcohol ethers, such as ethoxylated fatty alcohols of 10 to 20 carbon atoms including the lauryl, cetyl, stearyl, isostearyl, oleyl. and cholesterol alcohols, having attached thereto from 1 to 50 ethylene oxide groups or 1 to 50 propylene oxide groups: 9. ether-esters such as fatty acid esters of ethoxylated fatty alcohols; 10. Lanolin and derivatives, such as lanolin, lanolin oil, lanolin wax. lanolin alcohols, lanolin fatty acids, isopropyl lanolate. ethoxylated lanolin, ethoxylated lanolin alcohols, ethoxylated cholesterol, propoxylated lanolin alcohols, acetylated lanolin alcohols, lanolin alcohols linoleate. lanolin alcohols ricinoleate. acetate of lanolin alcohols ricinoleate. acetate of ed oxylated alcohols- esters, hydrogenolysis of lanolin, ethoxylated hydrogenated lanolin, ethoxylated sorbitol lanolin, and liquid and semisolid lanolin absorption basesand the like; 1 1. polyhydric alcohol esters, such as. ethylene glycol mono and di-fatty acid esters, diedrylene glycol mono-and di-fatty acid esters, polyed ylene glycol (200-6000) mono- and di-fatty acid esters, propylene glycol mono- and di-fatty acid esters, polypropylene glycol 2000 monooleate, polypropylene glycol 2000 monostearate, ethoxylated propylene glycol monostearate, glyceryl mono- and di-fatty acid esters, polyglycerol polyfatty esters, ethoxylated glyceryl monostearate, 1,2-butylene glycol monostearate, 1,2-butylene glycol distearate. polyoxyetivylene polyol fatty acid ester, sorbitan fatty acid esters, and polyoxyethylene sorbitan fatty acid esters are satisfactory polyhydric alcohol esters; 12. wax esters such as beeswax, spermaceti, myristyl myristate, stearyl stearate: 13. beeswax derivatives, e.g. polyoxyethylene sorbitol beeswax; 14. vegetable waxes including carnauba and candelilla waxes; 15. phospholipids such as lecitiiin and derivatives; 16. sterol including cholesterol and cholesterol fatty acid esters; 17. amides such as fatty acid amides, ethoxylated fatty acid amides, solid fatty acid alkanolamides.
Humectants may be added to the composition to increase the effectiveness of die emollient, to reduce scaling, to stimulate removal of built-up scale and improve skin feel. By way of example only, suitable humectants include polyhydric alcohols, such as glycerol, polyalkylene glycols, alkylene polyols dieir derivatives, propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol, sorbitol, hydroxypropyl sorbitol, hexylene glycol, 1,3-butylene glycol, 1,2,6-hexanetriol, etiioxylated glycerol, propoxylated glycerol and the like. The amount of humectant may be in the range of about 0.5-30 wt% and preferably between 1-15 wt%. In topical skin care applications, a variety of active substances may be advantageously employed. By way of example only suitable active agents which may be incorporated into the cosmetic composition include anti-aging active substances, anti-wrinkle active substances, hydrating or moisturizing or slimming active substances, depigmenting active substances, substances active against free radicals, anti- irritation active substances, sun protective active substances, anti-acne active substances, firming-up active substances, exfoliating active substances, emollient active substances, and active substances for the treating of skin disorders such as dermatitis and the like. By way of example only, in me case of hydration, one or more moisturizers may be used, such as glycerin or urea, in combination with one or more precursor agents for the biosythesis of structural proteins, such as hydroxyproline, collagen peptides and the like.
By the way of example only, in case of slimming, at least one ketolytic agent or an alpha-hydroxyacid such a salicylic acid or 5-n-octanoicsalicylic acid may be used in combination with at least on liporegulating agent such as caffeine.
By way of example only, in the case of depigmentation, at least one keratolytic agent is used in combination with a depigmenting agent such as hydroquinone, tyrosinasee inhibitor (kosic acid), ascorbic acid, kojic acid and sodium metabisulfite an the like. By way of example only, in die case of protection against free radical agents, vitamin E (against COO radicals), superoxide dismutase (against O2 free radicals) and sugar and caffeine (against OH' free radicals).
By way of example only, in the case of anti-aging, moisturizers, sunscreens, alpha-hydroxyacids, salicylic acid or surface restructuring agents may be used in combination witii enzymes for the repair of DNA, vascular protective agents or phospholipids rich in oligoelements and polyunsaturated fatty acids.
By way of example only, in die case of anti-acne agents, keratolytics, such as salicylic acid, sulfur, lactic acid, glycolic, pyruvic acid, urea, resorcinol and N- acetylcvsteine, and retinoids. such as retinoic acid and its derivatives may be used.
By way of example only, in the case of anti- inflammation, non-steroidal anti- inflammatory agents (NSAIDS) may be used, such as propionic acid derivatives, acetic acid, fenamic acid derivatives, biphenylcarboxylic acid derivatives, oxicams. including but not limited to aspirin, acetaminophen, ibuprofen. naproxen. benoxaprofen, flurbiprofen, fenbufen, ketoprofen. indoprofen. pirprofen, carporfen, and bucloxic acid and the like.
By way of example only, in the case of antibiotics and antimicrobials may be included in the composition of the invention. Antimicrobial drugs preferred for inclusion in compositions of the present invention include salts of β-lactam drugs. quinolone drugs, ciprofloxacin, norfloxacin. tetracycline, er τhromycin. amikacin, triclosan. doxycycline, capreomycin. chlorhexidine, chlortetracycline, oxytetracycline. clindamycin, ed ambutol. hexamidine isethionate, metronidazole, pentamidine, gentamicin. kanamycin. lineomycin. methacycline. methenamine, minocycline, neomycin, netilmicin, paromomycin. streptomycin, tobramycin. miconazole and amanfadine and the like.
By way of example only, in the case of sunscreen protection, suitable agents include 2-ed ylhexyl p-methoxycinnamate, 2-ethylhexyl N.N-dimethyl-p- aminobenzoate, p-aminobenzoic acid, 2-phenyl p-meti oxycinnamate, 2-etiτylhexyl octocrylene, oxybenzone, homomenmyl salicylate, octyl salicylate, 4,4' -methoxy- 1- butyldibenzoylmethen, 4-isopropyl dibenzoylmediane, 3-benzylidene camphor, 3-(4- methylbenzylidene) camphor, titanium dioxide, zinc oxide, silica, iron oxide, and mixtures thereof and the like. The sunscreening agents disclosed therein have, in a single molecule, two distinct chromophore moieties which exhibit different ultra-violet radiation absorption spectra. One of the chromophore moieties absorbs predominantly in the UVB radiation range and the otiier absorbs strongly in die UNA radiation range. These sunscreening agents provide higher efficacy, broader UN absorption, lower skin penetration and longer lasting efficacy relative to conventional sunscreens. Generally, the sunscreens can comprise from about 0.5% to about 20% of die compositions useful herein. Exact amounts will vary depending upon the sunscreen chosen and the desired Sun Protection Factor (SPF). SPF is a commonly used measure of photoprotection of a sunscreen against erythema.
By way of example only, in the case of sunless tanning agents include, dihydroxyacetone, glyceraldehyde. indoles and their derivatives, and the like.
The composition may include cleansing surfactants. Cleansing surfactants are cationic, anionic. amphoteric or non-ionic surfactants which are water-soluble and produce a consumer-acceptable amount of foam. Νonionic surfactants are well-known materials and have been used in cleansing compositions. Therefore, suitable nonionic surfactants include, but are not limited to, compounds in the classes known as alkanolamides, block copolymers of ethylene and propylene. ethoxylated alcohols, ethoxylated alkylphenols, alkyl polyglycosides and mixtures diereof. In particular, die nonionic surfactant can be an ethoxylated alkylphenol. i.e., a condensation product of an alkylphenol having an alkyl group containing from about 6 to about 12 carbon atoms in either a straight chain or branched chain configuration with ethylene oxide, d e etirylene oxide being present in an amount equal to at least about 8 moles ethylene oxide per mole of alkylphenol. Examples of compounds of this type include nonylphenol condensed with about 9.5 moles of ethylene oxide per mole of phenol; dodecylphenol condensed with about 12 moles of ediylene oxide per mole of phenol; dinonylphenol condensed widi about 15 moles of ethylene oxide per mole of phenol; octylphenol condensed with about ten moles of ethylene oxide per mole of phenol; and diisooctyl phenol condensed with about 15 moles of ethylene oxide per mole of phenol.
A wide variety of acids, bases, buffers, and sequestrants can be utilized to adjust and/or maintain die pH and ionic strengtii of die compositions useful in d e instant invention. Materials useful for adjusting and/or maintaining d e pH and/or d e ionic strength include sodium carbonate, sodium hydroxide, hydrochloric acid, phosphoric acid, sulfuric acid, acetic acid, sodium acetate, sodium hydrogen phosphate, sodium dihydrogen phosphate, citric acid, sodium citrate, sodium bicarbonate, triethanolamine, EDTA, disodium EDTA, tetrasodium EDTA, and the like.
The polymer network may be useful as a solubilization agent in cosmetic and personal care applications. A self-assembling system comprising the reversibly gelling polymer network exhibits thermogelation. pH sensitivity, and d e ability to solubilize hydrophobic agents in aqueous media. When poloxamer is copolymerized with poly(acrylic acid) (PAA) according to die invention, the resulting copolymer network is bioadhesive and can be applied in a number of therapies. The materials described in this invention combine "reverse" thermoviscosification mucoadhesion, solubilization of hydrophobic and difficult to manage moieties, easy formulation, and protection of agents from degradation to provide a superior medium for cosmetic and personal care products.
The reversible viscosification of the polymer network at elevated temperatures makes the materials ideal for use as thickening agents in cosmetic and personal care products at any temperature above the transition. Another use of the "d ickening" of solutions containing the polymer network as a thickener supplement in emulsions. Currently emulsifiers are often negatively effected by increased temperatures. An additive witii reverse thermal viscosification properties, however, would react in exactly the opposite way, increasing its ability to emulsify as it gained three- dimensional structure upon heating above its transition temperature.
In the applications where the reversibly gelling polymer composition can act as a surfactant, d e polymer network will have the ability to act as a primary emulsifier witiiout any (or with very little) addition of traditional surfactant. The responsive polymer network will also act as a stabilizer for oil-soluble ingredients that would conventionally need to be solubilized by oils in formulation. The hydrophobic portion of the polymer network (PPO) forms domains which act as reservoirs for an oil- soluble or hydrophobic additive, such as an oil droplet, as is illustrated in Figure 9. These two features of the material of the invention would enable it to be used as a base in a cosmetic formulation that would be non-greasy due to lack of oils, such as petrolatum and mineral oil. The increase in viscosity above the transition temperature adds structure and yield value to d e water phase and results in a highly stable emulsion.
Thus, poloxamer:poly(acrylic acid) polymer network compositions are valuable materials in the formulation of cosmetic and personal care products. In particular, they may be useful as rheology modifiers, provide a cushioning effect on :ne skin, offer barrier properties and controlled release of actives. In addition, the polymer composition may serve as a surfactant and is compatible with most ingredients used in the cosmetic industry. The above properties of the poloxamer:poly(acrylic acid) polymer network provides a cosmetic composition that spreads evenly and smoothly and which leaves a lubricious feel to the skin. A sensory evaluation was conducted with seven random volunteers in order to determine the sensory effect of a cream formulation on the skin. An oil-free cosmetic formulation was prepared substantially as set forth in Example 33(b) and was compared to Nivea Oil Free, a product of Beiersdorf of Germany.
Volunteers placed unmarked samples on the skin and evaluated the formulation based upon its feel and texture. The samples were rated on a scale of 1 (bad) to 5 (good). The oil-free cosmetic formulation of the present invention scored equally to the Nivea Oil Free moisturizing product. Both samples scored a 3.5 on the rating scale. The observed thermal behavior of the reversibly gelling polymer network suggests that the increase in viscosity is due to aggregation of the hydrophobic portion of the poloxamer at the transition temperature which, because of bonding wϊtii the poly(acrylic acid) component, serve as temporary cross-links which physically bridge adjacent chains of poly(acrylic acid) to provide a viscous gel-like extended polymer structure. The aggregation process may be understood as occurring as shown in Figure 10, in which a backbone 20 represent poly( acrylic acid), a thin band 24 represents the hydrophobic poly(propylene) glycol region of the poloxamer and a thick band 26 represents the hydrophilic poly(ethylene glycol) region of the poloxamer. Below the transition temperature, the polymer network is randomly arranged, as is shown in Figure 10(a). At or above the transition temperature, the hydrophobic regions 24 associate to form aggregations or micelles 28, as is shown in Figure 10(b). The association increases die effective molecular weight of die polymer network composition with the corresponding increase in viscosity.
A general method of making the poloxameπPAA polymer network compositions of the present invention comprises solubilization of the poloxamer in acrylic acid monomer, followed by polymerization of the monomer to P.AA. Polymerization may be accomplished by addition of a polymerization initiator or by irradiation techniques. The initiator may be a free radical initiator, such as chemical free radical initiators and uv or gamma radiation initiators. Conventional free radical initiators may be used according to the invention, including, but in no way limited to ammonium persulfate. benzoin ethyl ether, benzyl peroxide. 1.2'-azobis(2.4- dimethylpentanitrile) (Vazo 52) and azobisisobutyronitrile (AIBN). Initiation may also be accomplished using cationic or ionic initiators. Many variations of this methods will be apparent to one skilled in the art and are contemplated as within the scope of the invention. For example, the poloxamer component may be dissolved in an acrylic acid/water mixture instead of pure monomer. It may be desirable to remove unreacted monomer and or free poloxamer from the resultant polymer network. This ma'y be accomplished using conventional techniques, such as. by way of example, dialysis or sohxlet extraction. Without intending to be bound by a particular mechanism or structure, the following scheme represents a possible chemical mechanism for the formation of the system here described. These mechanisms are presented by way of explanation and are no way limiting of the invention. It is contemplated tiiat d ese or other mechanistic routes may in fact occur in the formation of die polymer network of the present invention. I. Initiation
RR --> 2R« (1)
R. + CH2=CHCOOH — > RCH2CH.COOH (2)
II. Hydrogen Abstraction R. + -OCHRCH2O- — > RH + -OCR-CH2O-
(3) R- + -CH2CH2COOH --> RH + -CHXH-COOH
(4)
III. Chain Transfer -CHXH-COOH + -OCH2CRH- — > -CHXHXOOH + -OCHXR- (5)
-OCHXR.O- + XHXHCOOH — > -OCHXRHO- - XHXHXOOH (7)
IV. Propagation
RCHXHXOOH -r CH2=CHCOOH --> RCH:CHCOOHCH2CH.COOH (8)
V. Side Chain Branching Off AA Backbone -CHXH.COOH- -r CH =CHCOOH --> -CH:CH(CH;CH-COOH)COOH (9)
VI. AA Branching off Poloxamer Backbone
-OCHXR.O- - CH2=CHCOOH -> -OCHXR(CH2CH«COOH)O- (10)
VII. Homogenous Termination
2 -CHXHXOOH --> XHXHCOOHCHCOOHCH2- ( 1 1)
VIII. Heterogenous Termination with bonding of Pluronic to PAA -CHXHXOOH + -OCHX.RO- --> -CH2CH(-OCRCH2O-)COOH
(12a)
The scheme for bonding of poloxamer to acrylic acid may involve initiation (eq 1), hydrogen abstraction from the propylene or ethylene moiety of me poloxamer (eq 3), and attachment to acrylic acid via addition across the unsaturated bond (eq 10). Propagation (eq 8) leads to the final PAA.
Alternatively, the mechanism may proceed by initiation according to eqs. (1) and (2). propagation to form PAA (eq.8), a chain transfer reaction to generate a reactive poloxamer moiety (eq. 5), followed by addition of die reactive poloxamer moiety to die unsaturated bond of acrylic acid (eq. 10) and subsequent propagation of the PAA chain.
Thus the polymer network may include a plurality of poly(acrylic acid)) units bonded to a single poloxamer unit or, alternatively, a plurality of poloxamer units bound to a single PAA backbone. Combinations of tiiese alternatives are also a possibility.
Reverse phase polymerization may be used to prepare polymer network beads by dispersion of the poloxamer and acrylic acid monomer mixture in a nonpolar solvent such as hexane or heptane. The aggregating polymer/monomer solution is dispersed with agitation in the nonpolar solvent in order to suspend droplets of the solution. Polymerization of the monomer is initiated by conventional means (i.e.. addition of a initiator or irradiation) in order to polymerize the monomer and form responsive polymer network beads. See, U.S.S.N. 08/276.532 filed July 18, 1995 and entitled "Useful Responsive Polymer Gel Beads" for further information on the preparation of polymer gel beads, herein incorporated by reference. Such a method may be particularly desirable to provide a heat sink for the heat generated in the exothermic polymerization reaction.
The polymer network complexes and aqueous gelling solutions of d e present invention may be understood with reference to the following examples, which are provided for the purposes of illustration and which are in no way limiting of the invention.
Example 1 This example describes d e syntiiesis of a polymer network and an aqueous responsive polymer network solution prepared using a triblock polymer of poly(ethylene glycol) and poly(propylene glycol), Pluronic® F27 polyol, and poly(acrylic acid). This example also characterizes the gelation and d e physical properties of the resultant polymer network.
Synthesis. Block copolymer of poly(propylene glycol) (PPG) and polyethylene glycol) (PEG) having triad ABA structure (PEG)A(PPG)B(PEG)A (Pluronic® F127 NF polyol, Poloxamer 407 NF polyol, where "F" means Flakes, "12" means 12X300=3600 - MW of the PPG section of the block copolymer, "7" PEG in die copolymer is 70 wt%, and nominal molecular weight is 12,600) from BASF (3.0 g) was dissolved in 3.0 g acrylic acid (Aldrich). This represents a substantially 1 :1 weight ratio of Pluronic® F127 polyol and poly(acrylic acid). The solution was deaerated by N2 bubbling for 0.5 h and following addition of 100 ml of freshly prepared saturated solution of ammonium persulfate (Kodak) in deionized water was kept at 70 °C for 16 h resulting in a transparent polymer.
Viscosity measurements. A known amount of me resultant polymer was suspended in 100 ml deionized water into which NaOH was added. Following swelling for 3 days while stirring, the pH of the resulting fine suspension was adjusted to 7. Samples of 15 ml each were taken, and pH in each vial was adjusted to desired value by addition of 1 M HCl or NaOH. Samples were then kept overnight and their viscosities were measured at different temperatures using Brookfield viscometer using either an SC4-18 or an SC4-25 spindle.
A control experiment was done with a physical blend of Pluronic® F127 polyol and poly(acrylic acid) (MW 450.000) available from Aldrich. Pluronic® F127 polyol and poly(acrylic acid) were dissolved together in deionized water at 1 wt% total polymer concentration and the resultant solution was adjusted to pH 7, stirred and kept in refrigerator. The responsiveness of the polymer network composition and die physical blend to temperature and pH is illustrated in Figs. 1. 1 1 and 12. Figs. 1 and 2 clearly demonstrate that the syntiietic route outlined above resulted in a polymer network system that is sensitive to pH and temperature of the environment. Note that die liquid-gel transition is very sharp, occurring over a very small temperature change or pH (see, Figure 1 1). Figure 12 is a viscosity vs. temperature graph comparing the gelling characteristics of d e responsive polymer network composition and die physical blend. The blend prepared by physically mixing of the triblock PEG/PPG/PEG polymer and poly(acrylic acid) did not exhibit viscosifying effect eitiier as a function of temperature or pH.
It was generally observed diat 0.5-5 wt% polymer network compositions made of Pluronic® F127 polyol and poly(acrylic acid) viscosity at temperatures of around 30 °C and higher if pH is adjusted to 6 or higher. The gelling effect was observed in polymer network compositions standing 3 months or longer. Repeated heating and cooling of responsive polymer network compositions did not cause deterioration of d e polymer network or the gelling effect. Solutions of eitiier Pluronic® F127 polyol or poly(acrylic acid) (1-5 w% in water, adjusted to pH 6 or higher) or physical blends of the two lacked die reverse thermal gelling effects found for polymer network compositions.
Example 2. This example describes a standard operating procedure for the manufacture of the reversible gelling polymer network.
The procedure is based upon a 50 liter production. A NaOH solution was prepared by dissolving 131.8 g NaOH pellets in 131.8 mL Dl water (50% solution). The NaOH was allowed to dissolve completely. The NaOH solution will be used to convert a percentage of the acrylic acid to sodium aery late in situ. Acrylic acid monomer ( 4 kg) is charged into a monomer feed tank and agitated at 250 rpm. NaOH is added slowly. The precipitate formed as the acrylic acid is ueutralized to sodium acrylate is allowed to dissolve. Pluronic® F127 (3.5 kg) is slowly added to die monomer feed tank. Pluronic® F127 is dissolved under continued agitation. Norpar 12 (a refined C-12 alkane) is added to d e reaction vessel (37 L). The mixture is agitated at 100 rpm. Stabilizer solution of Ganex V-126 is prepared in 2L Norpar 12 and added to the reactor under agitation. A reaction vessel was degassed using a nitrogen sparge introduced from the bottom of reactor and was continued throughout the reaction. Initiator (13.63 g Lauryl peroxide and 4.23 g Vazo 52 in 0.7 kg acrylic acid monomer) is introduced into die monomer solution. The monomer solution was transferred to the reaction vessel. Agitation was increased to 150 rpm. Nitrogen sparging continued for an additional 20 minutes and then heating began. Heating began at a rate of 0.5-1.0 X/min up to
75 X. The reaction began to exotherm at about 45-50 X and is allowed to continue witiiout cooling until a maximum is reached. It is ien cooled to 75 X using forced cooling. The reaction continued for 12 hours and was d en cooled to 35 X. The slurry was transferred into pails and the polymer beads were allowed to settle. The slurry was filtered through Buchner Funnels with filter paper (11 μm pore size) until the bulk of die Norpar had been removed from the beads. The beads were washed d ree times with heptane. The filtered beads were transferred to a Pyrex drying tray and spread on die tray in a uniform layer. The beads were dried under vacuum for 4 hours at 40-50 X. The dried beads were analyzed as follows. Elemental analysis. The elemental analysis was performed by Quantitative
Technologies, Inc., Whitehouse, NJ using a Perkin Elmer 2400 CHN Elemental Analyzer. Analysis provided C (52.49%), H (7.50%), N (< 0.05%), the balance assumed to be oxygen (39.96%).
Thermal Gravimetric Analysis (TGA). The TGA method was performed by Massachusetts Material Research, Inc., West Boylston. MA using a Dupont TGA model 295. The assay was run using a temperature ramp from 30 to 500 X/min. The resolution for the system was set to 4 (1.0 X/min for all slope changes). The data was analyzed using die first derivative of the curve and using maxima and minima to mark transitions. The moisture content was also calculated in this manner. The first derivative yielded three maxima. The first transition (moisture) was 3.0% by weight, the second transition was 14.0%> by weight and die third was 67.02% by weight. Residue ( 15.98% remained).
Molecular weight determination bv gel permeation chromatography (GPC). The molecular weight was determined by GPC on a Hewlet Packard 1100 Liquid Chromatography system with a Viscotech T60 Triple Detector system. Three Waters Ultrahydrogel columns. 1000, 500 and 250 A. were used for the separation. The mobile phase was 0.1M NaNO3 and 0.01M K2HPO4 salt solution, pH adjusted with phosphoric acid to a pH of 8.0 ± 0.1. The flow rate for the separation was 0.9 mL/min. The column temperature was maintained at 15 X. The injection volume for the assay was 50 μL. A PEG molecular weight standard of 23,000 Daltons was used to align the detectors. The result for the assay were:
Mn: 341,700 Daltons M-: 1,607,000 Daltons Mw: 2,996,000 Daltons Free poloxamer determination bv GPC. The amount of free (unbound) poloxamer in the polymer matrix was determined using die above GPC metiiod and comparing the poloxamer peaks to diat of a standard poloxamer solution. The typical result is approximately 18-22% free poloxamer by weight.
The effect of botii die bonded and non-bonded poloxamer on the gelation properties of the responsive polymer network has been determined by extraction of d e non-bonded poloxamer from die material. Such extraction studies have established diat die graft co-polymer alone exhibits the characteristic reverse thermal gelation of the composition; however, the presence of non-bonded poloxamer component modulates d e gelation process. The non-bonded poloxamer component can affect d e temperature of transition (from liquid to gel) and die degree of transition and assists in a more controlled and reproducible transition.
Bound poloxamer determination bv ethylene oxide fEO titration. The EO titration was performed as follows. A 5 gm sample of the product polymer was extracted in dichloroethane for three hours at reflux temperatures. The solid is removed and dried under a vacuum for 12 hours at room temperature. The dry material is then analyzed using ASTM method D 2959-95, "Standard Test Method for Ethylene Oxide Content". The amount of EO in the sample is related to the amount of poloxamer bound to the polymer. The typical result is approximately 15 % by weight of EO. The relative amount of free poloxamer may be varied dependent upon die relative proportions of starting materials and the method of polymerization. Although d e residual solids presumably contain only poloxamer which is bonded to die poly(acrylic acid), i.e. , a graft co-polymer, the material still shows strong viscosification when it is neutralized and dissolved in water. However, the temperature of viscosification is increased substantially and d e degree of viscosification per gram of total solids is increased by removal of free poloxamer. Thus, die free poloxamer plays a role in modifying d e extent and temperature of viscosification. The poloxamer undergoes conformational changes and changes to die critical micelle concentration as a function of temperature. The poloxamer will change from an open, non-aggregated form to a micellular, aggregated form with changes in temperature.
Residual acrylic monomer determination by gas chromatography (GC). The residual acrylic acid monomer was determined by GC analysis using a Hewlet Packard GC 5890A, using a HP-FFDAP-TPA 10 m x 0.53 mm x lμm column. The sample was extracted and run in metiianol. Using an internal standard ratio, the sample was compared to a one point calibration. The typical results for this assay were below 70 ppm acrylic acid monomer.
Residual Norpar solvent bv GC. The residual Norpar in d e sample was determined by GC using the above method and comparing the Norpar peaks to that of a standard. The typical results were below 1.5 wt%.
UN- vis spectrum. Optical clarity data of UV-vis spectrophotometer was obtained. A 1.0% solution in water was prepared and measured at 420 nm. Transmittance (%) was typically greater than 90%.
Differential scanning calorimetrv fDSCV The DSC was performed by Massachusetts Material Research. Inc.. West Boylston. MA using a temperature ramp from 30 to 350 X at 5 X/min. The resolution for the system was set to 4 (l.OX/min for all slope changes). The assay yielded one endothermic event at 265 X, typically 270 J/g.
Examples 3-9. This example describes the synthesis of a several reversible thermal gelling polymer network prepared using a variety of poloxamers and poly(acrylic acid). The gelation and the physical properties of the resultant polymer network compositions are reported in Table 2.
Table 2.
Example 10. The following example demonstrates the effect of hydrophilic/hydrophobic ratio on the gelling temperature. Polymer network compositions were prepared from the following poloxamers shown in Table 3. Table 3. Composition of poloxamers investigated.
Table 3 shows that in this series, the fraction of PEG is reduced when the molecular weight of the PPG block is kept constant. Linse (Macromol. 26:4437-4449 (1993)) report phase diagrams for these copolymers in water were calculated and it was shown d at two-phase boundaries corresponding to the beginning of aggregation are almost unaffected by the molecular mass, given a constant PEG/PPG ratio, whereas these boundaries shifted to lower temperature as d e PEG content of the polymer is reduced at constant mass. The strong dependence of the PEG/PPG ratio is a consequence of the differing solubilities of PEG and PPG in water at the elevated temperamres. Thus one would suppose that aggregation that causes viscosification in die responsive polymer network composition should shift to lower temperature as PEG fraction decreases.
The poloxamer (3.0 g) was dissolved in 3.0 g acrylic acid. The solution was deaerated by N2 bubbling for 20 min. and following addition of the 100 :1 of freshly prepared saturated solution of ammonium persulfate in deionized water was kept at 70 °C for 16 h resulting in a strong whitish polymer. A sample of the polymer obtained (0.4 g) was suspended in 40 ml deionized water into which NaOH was added. Suspended responsive polymer network particles were allowed to dissolve under constant stirring. The resulting 1 wt% polymer network solutions were subjected to die viscosity measurement at shear rate of 132 or 13.2 sec using a SC4- 18 spindle. It can be seen from Figure 16 that, firstly, viscosity of the 1 wt% responsive polymer network solutions before viscosification (at 20-24 °C) decreases in the series (PEG)37(PPG)56(PEG)37(F103) > (PEG)25(PPG)56(PEG)25(F104) > (PEG)ι6(PPG)S6(PEG)16(F105) and, secondly, the temperature at which gelation shifts from about 45 °C for (PEG)37(PPG)56(PEG)37 to about 35 °C for (PEG)25(PPG)56(PEG)25 and (PEG)16(PPG)56(PEG)16. Botii results are in excellent agreement with d e theory set forth in Linse.
Example 11. The following example is related to release of and active agent from a poloxamer: poly(acry lie acid) polymer network. Drug loading and kinetics of release of the protein hemoglobin from poloxamer:poIy(acryIic acid) polymer network is described.
Synthesis. Pluronic® F127 (3.0 g) was dissolved in 3.0 g acrylic acid. The solution was deaerated by N2 bubbling for 0.5 h and following addition of 100 FI of freshly prepared saturated solution of ammonium persulfate (Kodak) in deionized water was kept at 70°C for 16 h resulting in a transparent polymer. The resultant responsive polymer network obtained (5 g) was suspended in 95 ml deionized water into which NaOH was added. The resulting suspension was allowed to swell for 7 days.
Hemoglobin loading and release. A 5 wt% responsive polymer network composition (3 g) was allowed to swell for 16 h in 10 ml of 0.25 mg/ml solution of human hemoglobin (Sigma) in deionized water adjusted to pH 8. The resulting mixture was well shaken and placed into the feed chambers of customized vertical, static, Franz-like diffusion cells made of Teflon. The feed and receiver chambers of the diffusion cells were separated by mesh screens (# 2063). The receiver chamber was continuously stirred by a magnetic bar. The cells were allowed to equilibrate to either 25 or 37 °C (in an oven). The feed and receiver phases consisted of 1 g of the hemoglobin-loaded responsive polymer network and 6 ml of phosphate-buffered saline (pH 7.4), respectively. In the control experiment, d e feed phase was made of 1 g of 0.25 mg/ml hemoglobin solution. After the feed solution had been loaded into the cell, the kinetic time commenced. Samples of the receiver phase was withdrawn from time to time and their absorbance was measured spectrophotometrically at 400 nm. To calculate hemoglobin concentrations, corresponding calibration curves (absorbance in PBS versus hemoglobin concentration) were generated. The results of the kinetic experiment are presented in Figure 17. It can be seen that the rate of hemoglobin release from the polymer network was substantially lowered at 37 °C when compared to that at 25 °C, because of viscosity increase in the polymer network at elevated temperatures (see Figure 1). The protein released from the polymer network composition still retained its native structure, as was determined by comparison of uv- vis spectra of release hemoglobin and natural hemoglobin.
Example 12. The following example is related to release of an active agent from a poloxamer: poly (aery lie acid) poiymer network. Drug loading and kinetics of release of the protein lysozyme from a polymer network is reported.
Lysozyme loading and release. A 5 wt% responsive polymer network composition (3 g) was allowed to swell for 16 h in 10 ml of 1 mg/ml solution of chicken egg-white lysozyme (Sigma) and 1.5 mg/ml sodium dodecyl sulfate (Aldrich) in deionized water adjusted to pH 8.5. The resulting mixmre was well shaken and placed into the feed chambers of customized vertical, static, Franz-like diffusion cells made of Teflon. The feed and receiver chambers of the diffusion cells were separated by mesh screens (# 2063). The receiver chamber was continuously stirred by a magnetic bar. The cells were allowed to equilibrate to either 25 or 37 °C (in an oven). The feed and receiver phases consisted of 1 g of the lysozyme-loaded responsive polymer network and 6 ml of phosphate-buffered saline (pH 7.4), respectively. In the control experiment, the feed phase was made of 1 g of 1 mg/ml lysozyme solution. After the feed solution had been loaded into die cell, the kinetic time commenced. Samples were withdrawn and their absorbance measured spectrophotometrically at 280 nm. A calibration curve was prepared for lysozyme concentration ranging from 0 mg/ml to 0.5 mg/ml in phosphate buffered saline. The results of the kinetic experiment are presented in Figure 18. It can be seen that the rate of lysozyme release from the responsive polymer network composition was substantially lowered at 37°C when compared to that at 25 °C, because of viscosity increase in responsive polymer network at elevated temperamres (see Figure 1). In order to demonstrate the retention of the enzymatic activity of lysozyme, die lysozyme released from the responsive polymer network composition was assayed using Micrococcus lysodeikticus cells and compared to d at of original lysozyme. The enzymatic activity of lysozyme was die same, witiiin die error of the assay (15%), as diat of die original lysozyme. Control witiiout lysozyme in presence of sodium dodecyl sulfate did not show any appreciable lysis of the cells.
Example 13. The following example is related to release of an active agent from a poloxamer:poly(acrylic acid) polymer network. Drug loading and kinetics of release of insulin from a responsive polymer network composition is reported. Insulin loading and release. A 5 wt% responsive polymer network composition (3 g) was allowed to swell for 16 h in 10 ml of 5 mg/ml solution of bovine Zn2+-insulin (Sigma) in deionized water adjusted to pH 7. The resulting mixmre was well shaken and placed into the feed chambers of customized vertical, static, Franz-like diffusion cells made of Teflon. The feed and receiver chambers of the diffusion cells were separated by mesh screens (# 2063). The receiver chamber was continuously stirred by a magnetic bar. The cells were allowed to equilibrate to either 25 or 37 °C (in an oven). The feed and receiver phases consisted of 1 g of the insulin-loaded responsive polymer network and 6 ml of phosphate-buffered saline (pH 7.4), respectively. In the control experiment, the feed phase was made of 1 g of 5 mg/ml insulin solution. After the feed solution had been loaded into the cell, d e timing commenced. Samples were withdrawn and their absorbance was measured spectrophotometrically at 280 nm. A calibration curve was prepared for insulin concentration ranging from 0 mg/ml to 1.25 mg/ml in phosphate buffered saline. The results of the kinetic experiment are presented in Figure 19. The rate of insulin release from responsive polymer network was substantially lowered at 37 °C when compared to that at 25 °C, because of viscosity increase in responsive polymer network at elevated temperamres (see Figure 1).
Example 14. This example demonstrates the preparation of a sterile reversibly gelling polymer network aqueous composition and die stability of die composition to sterilization. The polymer network is prepared as described in Example 1 , except that die composition is prepared at 2 wt% Pluronic® F127 polyol/poly (aery lie acid). After dissolution of the 2 wt% polymer network in water, the viscosity is measured. The composition dien is sterilized by autoclaving at 121 °C, 16 psi for 30 minutes. Viscosity is determined after sterilization. The corresponding curves for viscosity (a) before and (b) after sterilization are shown in Figure 20 and establish that minimal change in die viscosity profile of d e material has occurred with sterilization.
Examples 15-30. These examples show additives which may be used to affect die transition temperature overall viscosification of the polymer network composition.
A 1 wt% polymer network was prepared in deionized water at pH 7 in which a variety of additives were included in d e composition. The effect of the additive was determined by generation of a Brookfield viscosification curve. Results are reported in Table 4.
Table 4.
Example 31. Because of the surfactant nature of the polymer network composition coupled with the gelation effect of d e polymer network composition, it is possible to prepare formulation which are 100% water-based, but which are lubricous and thick.
Formulations including a nonionic surfactant formulation: An O/W (oil-in- water) emulsion was made by combining me following ingredients utilizing conventional mixing techniques:
Table 5.
Into a vessel equipped with a high efficiency homogenizer, d e formula amount of all ingredients is added, water is added to 100% w/w and allowed to mix to homogeneity. This formulation contains a nonionic surfactant and gives an emulsion that is fluid at room temperature but viscosifies above 32 X.
Formulations including a cationic surfactant formulation: An O/W (oil-in- water) emulsion was made by combining the following ingredients utilizing conventional mixing techniques:
Table 6.
Ingredient % w/w
10 % wt. 1 : 1 responsive 20Λ) polymer network as prepared in Example 1
Behentπmonium Methosulfate 5 (and) Cetearyl alcohol1 Mineral Oil 3U
1 Incroquat Behenyl TMS available from Croda Into a vessel equipped with a high efficiency homogenizer, the formula amount of all ingredients is added and allowed to mix to homogeneity. This formulation contains a cationic surfactant and gives an emulsion that is fluid at room temperamre but viscosities above 32 °C.
Formulations including an anionic surfactant formulation: An O/W (oil-in- water) emulsion was made by combining me following ingredients utilizing conventional mixing techniques:
Table 7.
rodafos ava lable from Croda Into a vessel equipped with a high efficiency homogenizer, the formula amount of all ingredients is added, water is added to 100% w/w and allowed to mix to homogeneity. This formulation contains a anionic surfactant and gives an emulsion that is fluid at room temperamre but viscosifies above 32 °C.
Example 32. Acne Medication: An oil-free, clear, anti-acne treatment is made by combining the following ingredients utilizing conventional mixing techniques:
Table 8.
erma en ava a e rom utton a orator es To one vessel, equipped with a Lightnin' Mixer with a 3 blade paddle prop, die full amount of USP Purified Water to 100% w/w is added. While maintaining die temperature, with moderate to vigorous mixing, the formula amount of Disodium EDTA, Citric Acid, DL-Panti enol, Glycerin, Salicylic Acid, and Germaben® II is added. These materials are allowed to dissolve at 50°C. After dissolution, die vessel is then cooled to 20°C. To another vessel, equipped with a high efficiency homogenizer, me formula amount of responsive polymer network is added. The responsive polymer network vessel is then cooled to 4°C. After cooling, while vigorously homogenizing, die contents of die first vessel is added to die second vessel, and allowed to mix to homogeneity. The composition displays a flowable clear jelly appearance with excellent spreadability and absorption characteristics at room temperamre, and after heating the formulation to 32°C, the composition thickens to a gel-like consistency.
Example 33. (a) Oil-free Moisturizer (formulation I): An oil-free, lubricous moisturizer was made by combing the following ingredients utilizing conventional mixing techniques:
Table 9.
ermaben II ava lable from Sutton Laboratories
The above ingredients were added and processed as described above for the acne composition. The composition displayed a flowable creamy lotion appearance with excellent emolliency, spreadability and absorption characteristics at room temperamre. After heating the formulation to above 26 °C, die composition thickened to a gel-like consistency. The viscosity vs. temperamre curve is shown in Figure 21 and demonstrates that addition of adjuvants to the composition significantly enhances the responsive polymer network maximum viscosity ( > 900,000 cps). The use of the poloxamer: poly(acry lie acid) polymer network in the formulation also imparts a unique viscosification effect after application to the skin, which is not evident in typical commercial O/W emulsion formulations (See, Figure 21b).
(b) Oil-free Moisturizer (formulation II): An oil-free, lubricious moisturizer was made by combing the following ingredients utilizing conventional mixing techniques: Table 10.
The above ingredients were added and processed as described above for the acne composition. The composition displayed a flowable creamy lotion appearance with excellent emolliency, spreadability and absorption characteristics at room temperamre. After heating the formulation to 26 , me composition thickens to a gel-like consistency. The addition of adjuvants to the composition sigmficantly enhances the polymer network maximum viscosity.
Example 34. Sunscreen Lotion. An oil-free, lubricious sunscreen lotion was made by combining the following ingredients utilizing conventional mixing techniques:
Table 11.
The above ingredients were added and processed as described above for the acne composition. The composition displayed a flowable creamy lotion appearance with excellent emolliency, spreadability and absorption characteristics at room temperamre. After heating the formulation to above 26 . the composition thickened to a gel-like consistency. The addition of adjuvants to the composition significantly enhances die polymer network maximum viscosity.
Example 35. Facial mask. A face mask was made by combing the following ingredients utilizing conventional mixing techniques:
Table 12.
The above ingredients were added and processed as described above for the acne composition. The composition displayed a flowable creamy lotion appearance with excellent emolliency, spreadability and absorption characteristics at room temperamre. After heating the formulation to above 26 , d e composition thickened to a gel-like consistency. The addition of adjuvants to die composition significantly enhances me polymer network maximum viscosity.
Example 36. Facial toner. A face mask was made by combing the following ingredients utilizing conventional mixing techniques:
Table 13.
The above ingredients were added and processed as described above for the acne composition. The composition displayed a flowable appearance with excellent emolliency, spreadability and absorption characteristics at room temperamre. After heating the tormulation to above 26 X, the composition thickened to a gel-like consistency. The addition of adjuvants to the composition significantly enhances the polymer network maximum viscosity.
Example 36. Solubilization studies of model hydrophobic agents in the poloxamer: polv(acrylic acid) polymer network: estradiol and progesterone. This example is presented to demonstrate the solubilization of a hydrophobic agent in d e polymeric network. Progesterone and estradiol were used as d e hydrophobic agents in this model solubilization study.
Acrylic acid (99%), fluorescein (98%), /3-estradiol (98%), and progesterone (98%) were all obtained from Aldrich and used as received. Pluronic® F127 NF was obtained from BASF. Poly(oxyethylene-b-oxypropylene-b-oxyethylene)-g-poly(acrylic acid) copolymers (responsive polymer network ) were synthesized by free-radical polymerization of acrylic acid in the presence of poloxamer as described above. The polymer network copolymers discussed here were composed of about 1 : 1 ratio of PAA to poloxamer. The rheological properties of polymer network were assessed using LVDV-II-. and RVDV-II + Brookfield viscometers. The microscopic light scattering of 21 nm poly(styrene) latex particles in deionized water and 1 w% reversibly gelling polymer network was measured using He-Ne laser as described previously (See, Matsuo, E.S. , Orkisz, M. , Sun, S.-T. , Li, Y. , Tanaka, T., Macromolecules, 1994, 27, 6791). The solubility of fluorescein and hormones in aqueous solutions was measured by d e equilibration of excess solubilizate witii the corresponding solution following removal of undissolved species by centrifugation and filtration. Hydrophobic agents were assayed spectrophotometrically at 240 (progesterone) or 280 nm (estradiol), or by using 70/30 w/w H2SO4/MeOH (Tsilifonis-Chafetz reagent). In vitro hormone release studies were conducted using thermostatted, vertical Franz cells. Spunbonded polypropylene microfilters (micron retention, 15-20) were used as a membrane separating feed and receiver phases in Franz cells. The responsive polymer network, water, ethanol, and 20% PEG in water were observed to wet the membrane. The receiver solutions consisted of 20 w% PEG in water (pH 7) and were stirred by magnetic bars. The feed phases composed of responsive polymer network were loaded widi eitiier estradiol or progesterone. Each hormone was dissolved in etiianol and the resulting solution was added into the responsive polymer network.
Equilibrium solubility vs. temperature plots for estradiol and progesterone (partition coefficient octanol/water (P) 7200 and 5888, respectively, in aqueous solutions of Pluronic® F127 polyol and responsive polymer network are presented in Figure 22. It can be seen that increasing temperamre and concentration (C) of polymers in the solution raises the amount of the hormone dissolved. In Figure 22a, vertical lines represent critical micellar temperatures (CMT) for corresponding Pluronic F127 polyol solutions. It is interesting to note mat the slope of the solubility-temperature plots increased as temperamre reached CMT, indicating that solubilization in he Pluronic solutions was predominantly due to the formation of micelles. Similar trend was observed in the responsive polymer network solutions. The S values in 5% aqueous solutions of branched PAA did not exceed 15 and 40 μg/mL at 60 °C for estradiol and progesterone, respectively. The solubility values found for responsive polymer network were the same as S in parent Pluronic solutions of equivalent concentrations. Therefore, it may be suggested that solubilization behaviors of d e responsive polymer network are governed by the properties of the poloxamer incorporated into it. Thermodynamic parameters of the solubilization process with responsive polymer network were calculated using the same approximations as in the micellar solubilization widi Pluronic polyols. See, Saito,Y. , Kondo, Y. , Abe, M. , Sato, T. , Chem. Pharm. Bull. , 1994, 42, 1348. Namely, partition coefficient P was estimated from equilibrium solubilities of estradiol in responsive polymer network and water:
P=SSH/SW (13) by extrapolating the solubility plots of the steroid in Figure 22 to 100 % responsive polymer network. Using P values obtained from data in Figure 23, we calculated die standard free energy change (ΔG), standard enthalpy of solubilization (ΔH), and standard entropy of solubilization (ΔS) using die following expressions:
ΔG = -RTlnP; ΔH = -RΔlnP/Δ(l/T); ΔS = (ΔH - ΔG)/T (14)
Thermodynamic parameters obtained along with P values are given in Table 13. Apparent partition coefficients and tiiermodynamic parameters for solubilization of estradiol by responsive polymer network.
Table 13.
Negative ΔG values indicate spontaneous solubilization at all temperamres, whereas positive ΔH shows that the solubilization was endothermic, similar to the solubilization of estriol, as well as indomethacin, by d e poloxamer. Notably, ΔS of solubilization was always positive, suggesting d at die more ordered water molecules surrounding hydrophobic estradiol molecules moved to d e less ordered bulk phase when d e estradiol was transferred to the hydrophobic core of PPG segments in responsive polymer network. The aggregation of the PPG segments at elevated temperamres provides not only temporary cross-linking in the gel, but also a diermodynamically "friendly" environment for the hydrophobic drugs. Indeed, one can express the free energy of formation of the aggregate core-water interface in responsive polymer network as:
ΔG = [σPw(l- φ) + σWD<>](4ιrR2/n) (15) where σPw and σWD are the interfacial tensions between pure PPO polymer and water and between water and the drug, respectively; φ is die volume fraction of die drug witiiin PPO core; R is the effective radius of die core, and n is die aggregation number. Equation (3) shows that solubilization of a hydrophobic drug of high σWD should increase the stability of d e aggregate. The solubilization process was found to decrease the critical micellization concentration and substantially increase the micellar core radius in Pluronic surfactants (Hurter, P.N. et al. , "In Solubilization in Surfactant Aggregates", Christian, S.D., Ed. , Marcel Dekker, New York, 1995). A similar trend is indicated by die lowering the onset of gelation of die responsive polymer network upon solubilization of fluorescein (LogP 2.1) (Figure 24). The solubilization of hydrophobic drugs by responsive polymer network, analogous to the micellar solubilization of drugs by poloxamer, suggests that the responsive polymer network can be an effective vehicle in drug delivery.
Our in vitro study of hormone release from responsive polymer network shows an increase in the initial transport rate with either decreasing total polymer concentration in the formulation or decreasing temperamre (Figure 25). These effects are related to the changes in macroscopic viscosity of the responsive polymer network, which erodes more rapidly from the feed phase dirough the membrane into the receiver compartment as the viscosity decreases (Figure 26). The degree of the responsive polymer network erosion was measured by weighing hormone-loaded responsive polymer network before and after kinetic experiment.
Figure 27 shows that the relative amount of progesterone penetrating into the receiver phase decreased 4-fold with the increase of total polymer concentration, whereas the total relative amount of progesterone stayed almost constant as tθtal polymer concentration in the responsive polymer network increased. This result shows the existence of two routes of transport of hydrophobic drugs in our model system. Firstly, the drug incoφorated into aggregates within die responsive polymer network system can flow dirough the membrane along with die erosion of the responsive polymer network; secondly, the drug not associated wid die responsive polymer network aggregates can diffuse out of the responsive polymer network in the feed phase. The second process should not be related to die viscosity of the responsive polymer network. Indeed, the dynamic light scattering experiment shows no dramatic change of diffusivity of poly(styrene) latex particles in the responsive polymer network as temperamre rises diereby increasing macroscopic viscosity more than 10- fold (Figure 28). This result indicates diat d e viscosity of the responsive polymer network is essentially unaffected on die microscopic scale.
Appendix A attached.
APPENDIX A
Cosmetic Bench Reference
Function Definitions
Abrasive: abrades, smoothes, polishes Emollient: softens, smoothes skin
Absorbent powder- takes up liquids, sponge-like action Emuisifier: a surtace-acuve agent (surfactant) that promotes the formation ot water-in-oil or oil-in-water emulsions
Absorption base: torms water-in-oil emulsions
Enzymes: complex proteins produced by living cells that catalyze biochemical
Aciduient: acidifies, lowers pH. neutralizes alkalis reacuons at body temperature
Amphoteπc: capable of reacting chemically either as an acid or a base:
Fiber strands of natural or synthetic polymers: for instance, conon. wool, silk, amphoienc surfactants are compatible with anionic and cationic nylon, polyester surfactants
Film former solution of a polymer that forms films when the solvent evaporates
Analgesic: relieves pain after application to a surface
Antacid: neutralizes stomach acidity
Fixative, fixes or sets perfumes: retards evaporation: promotes longer lasting
Antibacterial, destrovs mhibits the growth/reproduction of bacteπa aroma
Anti-caking prevents or retards caking of powders, keeps powders free- Flavor, impaπs a characteristic taste (and aroma) to edible foods and dπnks. flowing sometimes used in lip products
Anti-dandruff: retards or eliminates dandruff Foam booster enhances quality and quantity of lather of shampoos
Antifoam. suppresses loam during mixing Foamer: a surface-acuve agent (surfactant) that produces foam, an emulsion ol
Anti-inflammatory- reduces, suppresses, counteracts inflammation air-in-water
Anti-irritant: reduces, suppresses or prevents lmtauon Foam stabilizer see Foam booster
Antimicrobial, destroys, inhibits or suppresses the growth of Fungicide inhibits or destroys growth of fungi microorganisms Geilant: a gelling agent: forms gels: includes a wide vaπerv of mateπals such
Antioxidant: inhibits oxidation and rancidity as polymers, ciavs and soaps
Antiperspirant: reduces or inhibits perspiration Glosser- tu ishes a surface luster or bπghtness. usuallv used in lip or hair products
Antipruritic: reduces or prevents itching
Hair colorant: see Colorant
Antiseptic inhibits the growth of microorganisms on the skin or on living tissue Hair conditioner see Conditioner
Antistat: reduces static by neutralizing electrical charge on a surface Hair dye imparts a new permanent or semi-permanent color to hair
Astringent: contracts organic tissue otter application Hair-set polymer polvmer and/or resins used to maintain desired hair shape
Binder- promotes cohesion ot powders Hair-set resin: see Hair-set polymer
Bleaching agent: lightens color, oxidizing agent Hair waving: see Reducing agent and Neutralize!-
Botanical, natural plant derivative Humectant: absorbs, holds and retains moisture
Buffer: helps maintain original pH (acidity or basicity) of a preparation Hydrotrope: enhances water solubility
Carrier- a vehicle or base used for a preparation Intermediate: basic chemicals which are chemically modified to obtain the desired function
Chelate: form a complex with trace-metal impurities, usually calcium or iron
Lathering agent: a surface active agent (surfactant) that torms a loam or lather
Colorant: adds color, may be a soluble dye or an insoluble pigment on mixing with air in solution: see also Foamer
Conditioner: improves condition of skin and hair
Lubricant: reduces fπcuoπ. smoothes, adds slip
Coupling agent: aids in solubilization or emulsificauon of incompauble
Moisture barrier retards passage of moisture or water components
Moisturizer aids in increasing die moisture content of the skin through
Decolorant: removes color bv adsorption, bleaching or oxidation humectant or barrier action
Denaturant: used to denature ethyl alcohol
Neutralizes an oxidizing agent used in hair waving that stops the action of the
Dental powder- powdered dentifπce reducing agent and re-establishes the disulfide linkages in hair
Deodorant: destroys, masks or inhibits formation of unpleasant odors Oil absorbent: see Absorbent powder
Depilatory- removes hair chemically Ointment base, an anhydrous mixture of oleaginous components used as a
Detergenf a surface-active agent (surfactant) that cleans by emulsifying oils vehicle for medicaments and suspens paniculate soil Opacifier opacifies clear liquids or solids
Disinfectant- destrovs pathogenic microorganisms Oxidant oxidizing agent, neutralizes reducing agents, bleaching agent
Dispersant promotes the formation and stabilization of adispersion or suspension Pearlant imparts a pearlescent texture and luster
Dve stabilizer see Stabilizer Perfume solvent' see Solvent and Solubilizer
Cc. metiL Bench Rererence 1 96 1.1 Peroxide stabilizer see Stabilizer Stabilizer added to stabilize emulsions and/or suspensions
Pigment a tinelv powdered insoluble substan-e used to import color luster or Stimulant produces a temporary increase in the tunctional octivitv ot an opocitv organism or αnv ot its pans
Plasticizer pljstiuzes i akes more flexible) polymeπ- tilms or tibers Surfactant I surface active agent) lowers surface tension between two
Polish smoothes adds doss and luster or more incompatible phases soaps detergents wetting agents solubizin- agents and emuisifving agents are tvpical surtactams
Polvmer α verv high molecular weiϋht compound consisting ot repealing surtactants areclassitiedasanionic canonic nonionic and amphotenc structural units anionic surtactams are negativelv charged Lanonic surtactams have
Powder o solid in ihe tor ot line particles no electrical charge
Preservative protects products Irom spoilage bv microorcanisms Suspending agent keeps tinelv divided solid particles in suspension
Propellant pressuπzed gas in a container used to expel the contents when Sweetener sweetens to provide a more pleasant taste pressure is released bv opening a vahe Tanning accelerator accelerates the tanning ot skin
Protein naturally occurring complex combinations ol omino acids Thickener thickens or increases viscositv/consistencv
Reducing agent reduces a chemical compound usuallv bv donatins electrons Thixotrope the propertv ot certain aels and emulsions ot becomin- more fluid neutralizes oxidizing agents or less viscous when shaken or suited
Refatting agent adds oils materials lo ihe surtaLe ot substrates e g skin and UV absorber used as a sunscreen and to protect preparations trom dearadation hair by UV radiation
Resin nonvolatile solid or semisolid organic substances obtained from plants UVA absorber jbsoros in the range 20 -400 nanometers mm) as exudates to prepared bv polvmeπzation ot simple molecules
UVB absorber absorbs in the range 290 _0 nanometers inmi
Sequestrant torms coordination complexes wnh positive ions
Wax anv ot numerous substances ot plant animal or svntheiic oπgin that
Siiicone poh eπc organic silicon compounds which are water resistant contain principally esters ol higher tattv acids and higher lattv alcohols tree
Skin protectant protects skin trom en ironmental fattv alcohols lattv acids and hvdrocarboπs mav also be present waxes derived trom petroleum products are mainlv high-molecular weight
Solubilizer sυlubi zes usuallv into aqueous vehicles normally insoluble hydrocarbons materials SULΠ as tragrances tlovors oils etc
Wetting agent a surtace active agent I surfactant I that lowers the surtace and
Solvent usuallv liquids capable ot dissol ing other substances interfacial tension facilitating the wetting ot surfaces
Functions
Abrasive Hydrochloπc acid Maπne collagen
Adzuki beans Lactic acid Mushroom (Coπolus versicolor) extract
Almond (Prunus amygdalus) meal, shell granules Nitric acid Musk rose (Rosa moschata) oil
Aluminum silicate Phosphoric acid Perfluorodecalin
Apπcot ( Prunus armemaca) kernel powder, shells Sodium bisulfate Quatemιum-51
Hydrated silica Sulfuπc acid Rubus thuπbergti extract
Jojoba (Buxus chinensis) seed powder Taitaπc acid Serum protein
Lu fa cylindnca Stenocalyx micalii extract
Olive stone granules AHA Tricholoma matsutake extract
Oyster shell powder Apple (Pyrus malus) extract
Peach (Prunus persica) pit powder Apπcot (Prunus armemaca) kernel powder Antibacterial
Peach (Prunus persica) stone granules Citric acid Ammonium iodide
Polyethylene Ethyl lactate Chlorhexidine
Polvethvlene HEC granules Glycolic acid Chlorhexidiπe diacetate. C. digluconate
Polyethylene oxidized. P. spheres Lactic acid Chlordexidine dihvdrochloπde
Polvstyrene Malic acid Chlorpheπesin
Pumice Sodium lactate Hexamidine dnsethionate
Rice (Oryza sauva) bran Tartaπc acid Hexetidine
Silica and S. colloidal Iceland moss (Cetraπa islandica) extract
Sodium chloride Antiacne Lactofemn
Walnut (Juglans regiai shell powder Clays (white, yellow, red. green, pink) Lauralkomum bromide. L. chloπde
Pertluorodecalin Lauππmonium chloπde
Absorption base Salicylic acid Laurylpyπdinium chloπde
1.2.6-Hexanetπol Sulfur Mauπuella armata extract
Kaolin Mushroom (Cordyceps saboliferal extract
Petrolatum Anti-aging Orange blossom extract
Rice (Oryza sativa) starch Basil (Ocimum basilicum) extract Orange (Citrus aurantium dulcis) peel extract
Soy (Glycine soja) sterol Carrot (Daucus carota) extract PEG-42 Ebiπko ceramides extract
Zeolite Catalpa kaemptera extract Peppermint ( Mentha pipeπta) extract
Ceramide 33 (liquid soy extract) Philodeπdron (Phellodendron amurense ) extract
Absorbent powder Crataegus cuneata extract Pine (Pinus sylvestπs) needle extract
Com (Zea mays) starch Eugenia jambolana extract Polymethoxy bicyclic oxazo dine
Maltodextnn Fomes fometanus extract Quatemium Ti
Nylon- 12 Fomistopsis pimcola extract Rubus thunbetgn extract
Oat ( Avena sauva) bran, flour, meal Ganoderma lucidum oil Tea tree I Melaleuca altemifo a) oil
Zeolite Ginseng (Panax ginseng) extract Tπciocarban
Hyaiuronic acid Undecylenic acid
Acidulent Hydrolyzed serum protein
Acetic acid Hydrolyzed sov flour Anticaking Citπc acid lsachne pulchella extract .Aluminum starch octenvlsuccinate Fumanc acid Lactofemn Calcium stearate Glutaπuc acid Lady's Thistle iSilvbum mananum) extract Distarch phosphate Glvco c acid Ligusϋcum jeholense extract Hvdrated silica
ffiΛ The Only Form of Gentle Efficacy
Natural • Odorless • Biodegradable • Custom colors • Mild or aggressive particles FLOMTΈCH
CORPORATE OFFICES • 115t N. Fiesta Blvd • Gilbert. AZ 85233 • (602) 545-7000 • Fax (602) 892-3000 • New York • Canada • EurODβ ■ Asia 77m Natural Solution
BRPOKS INDUSTRIES inc.
Cosmetic Ingredients ά Ideas*
70 Tyler Place, South Plainfield, NJ 07080 USA Multifruit Tel 908-561-5200 Fax 908-561-9174 Alpha Hydroxy Acids
"ALPHA HYDROXY ACIDS"
Glycolic Malic
Lactic Citric
Tartaric Ascorbic Allaπtoin Aloe Vera
Cosmetic Bench Reference 1996 1.5 Functions
Kaolin Mulberry (Moms mgra) extraα Domiphen bromide
Magnesium mvπstate. M silicate Niacinamide ascorbate Ethylparaben
Polyethylene, micromzed Orange (Citrus auranuum dulcis) peel extraα Eucalypnis (Eucalvpnis globulus) extraα
Silica silvlate Orange blossom extraα Fennel (Foemculum vutgare) extract
Sodium aluminum silicate Palmetto extraα Garlic (AUium sativnm) extract
Zinc stearate Palmitoyl collagen amino aαds Glyceryl caprylate, G laurate
Passion flower (Passi lora launfolia) fruit extraα Hexamidine dusethionate
Anticaries agent Paulowma impenaiis extraα Hinokiuol
Cetylamine hvdrofluoπde Salicylic aαd Honeysuckle ( oniccra capnfolium) extraα Olaflur Shea butter (Butyrospermum parkn) ϋchen (Usnea barbata) extract
Sodium fluoπde Sodium carboxvmethyl beta-glucan Myπstalkonium chloπde
Stearyl tπhvdroxvethvl propylenediamine Soy (Glyαne soja) protein Pentylcπe glycol dihvdroϋuoπde Stearyl glycyrrhetinate Phencthyl alcohol
Stenocalvx micalu extraα Phenol
Anticellulite Tocophervi acetate, T nicotinate Phenoxyethanol
Aminophviline Tπchomonas japomca extraα Phenoxyisopropanol
Bladder rack ( Fucus vesiculosus) extract Willow (Salix alba) extraα Phenyi mercuπc acetate, Pm benzoate, Pm borate
Butcherbroom ( Ruscus aculeatus) extract Witch hazei (Hamame s virgimana) extraα o-Phenvlphenol
Carcinia cambogia extract Withama sommferum extraα Polymethoxv bicvclic oxazolidine
Fomes tometaπus extract Yarrow (Achillea miilefolium) extraα Potassium sorbate
Fomistopsis pinicola extract Zinc lactate Propylparaben
Ivy extract Ricmoleamodopropyltπmo um ethosulfate
Mushroom (Coπolus versicolor) extract Anti-irritant Sage (Salvia officinalis) extract
TEA-hvdroiodide Acetvi monoethanolaπune Sodium benzoate. S pynthione
Tπcholoma matsutake extract Allantoui Sodium nαnoleate. S shale oil sulfonate
Allantoin acetyl methionine, A. glycyrτhetmιc aαd Thimerosal
Antidaπdruff Azela ide MEA Thyme (Thvmus vulgaπs) extraα
Burdock (Arctium lappa) extract Betaine Thymol
Chloroxvlenol Calendula officinalis extract Tπclocarban
Corγdaiis ambigua extract Cocamidopropyl betaine Tπclosan
Disodium undecvlenamido MEA-sulfosucαnate Coceth-7 carboxylic aαd Undecvlenamidopropv itnmonium methosulf ate
Guiger root extract Cornflower (Centaurea cvanus) extraα Undecvlemc aαd
Inga edulis extract Dnsostearvl dimer dilmoieate Zinc oxide. Z. PCA
Mauπtieila aπnata extract Dipal itovl cvstme Zinc pynthione, Z. undecvlenate
Mvπstalkomum saccharmate Green tea extract
PEG-6 undecvlenate Hydrolvzed sweet almond protein Antioxidaπt
Ptroctone olamme Hydroxvpropvltπmonium gelaun Ascorbic aαd
Resorcmol Lauroyl collagen ammo aαds A. polypeptide
Rosemarv (Rosmaπnus officinalis) extract 1- ysιne laurovl methionine Ascorbvl oleate. A. palmitate
Sodium shale oil sulfonate Mallow extraα Beta-carotene
Stenocalvx micalu extract Matπcaπa (Chamomilla reαiuta) extraα BHA
Undecvlenamide DEA Palmitovl hvdrolvzed milk protein BHT
Willow (Salix alba) bark extract Palmitovl hvdrolvzed wheat protein t-Butvl hvdroqumone
Zinc pvπdnone Palmitovl keratin amino aαds Dilaurv I thiodipropionate
PEG-12 palm kernel glvceπdes Dunvπstvl thiodipropionate
Antifungal PEG-28 glvcεrvl tallowate Disodium EDTA
Black walnut I Juglans mgra) extract PEG-30 glvcervl monococoate Distearvl thiodipropionate Coneflower (Echinacea angustifolia) extract PEG-60 almond glvceπdes Dodecvl gallate Orange blossom extract PEG-78 glvcervl cocoate EDTA Pfaffia pamculata extract PEG-82 glycervl tallowate Erythorbic aαd
PEG-200 glvcervl tallowate Fenilic aαd
Anti-iπflammatorv Propionvl collagen amino aαds Grape (Vitis vuufera) seed extraα
Allantoin polvgalacmromc aαd PVP Green tea extraα
Bisabolol Saccharomvces lysate extract HEDTA
Black poplar (Populus mgra) extract Sodium C12-15 pareth-15 sulfonate Hydroqtunone
Brassica rapa-depressa extract Sodium lauroamphoacetate Hydroquinoπe-beta-D-glucopvranoside
Butcherbroom (Ruscus aculeatus) extract Soy (Glvαne soja) protein p- Hydro xvamsoie
Calendula offiαnalis extract Undecvienovl collagen amino aαds Laαoferπn
Catalpa kaemptera exiract Valenan (Valeπana otfi nahs) extract Lysine PCA
Celast us pamculata extract Melanin
Ceramide 3 (liquid sov extract) Antimicrobial Methyl gallate
Chaparral (Larrea mexicana) extract Benzalkoruum chloπde Niacinamide ascorbate
Coneflower (Echinacea angustifoha) extract Benzoic aαd Nordihvdroguaiaretic aαd
Cornflower (Centaurea cvanus) extract Benzvl alcohol Oat (Avena sauva) extract
Dipotasstum glycyrrhizmate Bromochlorophene Oryzanoi
Euphotoπum fominei extract Pentasodium pentetate
2-Bromo-2-mtropropane- U-diol
Euphrasia officinalis extract Butylparaben Penteuc aαd
Ficus racemosa extraα Propyl gallate
Caprylovi collagen ammo aαds
Golden seal (Hvdrasus canadeπsis) root extraα Retinvl palmitate polypeptide
Caprylovi glyαne. C keratin ammo aαds Rosemarv (Rosmaπnus officinalis) extraα
Guaiazulene Captan Saccharomvces lvsate extraα
Horee chesmut (Aesculia hippocastanum) extract Cetethvldunomum bromide Sage (Salvia officinalis) extraα
Jujube (Zizvphus jujuba) extraα Cetvl pyndimum chloπde Sodium ascorbate, S erythorbate
Laimnaπa japomca extraα Chlorothvmol Sodium metabisulfite
Ucoπce (Glvcvrrhiza glabra) extraα Chloroxvlenol Sodium selenate. S. sulfite igusticum jeholense L luαdum extract Citron oil Superoxide dismutase
Matπcaπa (Chamoπulla reαinta) extract Copper PC A Tea (Camillia sineπsis) extract
Melaleuca uncinata extract Dichlorobenzvl alcohol Telrasodium EDTA
Melia azadirachta extract Dilaurv Idimonium chloπde Tocopherol
1 6 Cosmetic Bench Reference 1996 Functions
Tocophervl acetate. T linoleate Lactamidopropyl tπmomum chloπde Sambucus mgra oil
Wild marjoram (Oπganum vulgare) extraα Lauiyldunomum hvdroxvpropyl hydrolyzed collagen Sanguisotfoae root extraα
Yeast (Saccheromvces cerevtsiae) extraα (Faex) Luioleamidopropyi dimethylamine imer dilinoleate Seiinumspp extraα
Olealkomum chloπde Shorea robusota extract
Antiperspiraπt PEG-2 cocamine Tanmc aαd
Allantoin-aluimπum chlorhvdrate PEG-2 cocomomum chloπde Walnut (Juglans regia) leaf extract, oil Aluminum caprvlovl hvdrolvzed collagen PEG-2 oleammomum chloπde Wheat (Tπacum vulgare) protein Aluminum chlorhvdrex-gly, A chloπde PEG-β caprvlic capπc glyceπdes White nettle (Laπuum album) extraα Aluminum chlorohydrate, A chlorohvdrex PEG- 10 cocamine Witch hazel (Hamamehs virgimaπa) extraα Aluminum PCA. A sesquichlorohvdrate PEG-15 sovaπnπe Xanthozvlum bungeanum extract Aluminum undecvienovl collagen ammo acids PPG-9 diethvlmo um chloπde Zinc lactate Aluminum zirconium pentachiorhvdrate PPG-25 diethylmonium chloπde Ziziphus jujuba extraα Aluminum zirconium tetrachlorohydrate PPG-40 diethylmomum chloπde Aluminum zirconium tetrachlorohvdrex GLY Propylene glycoi stearate Binder Aluminum zirconium tπchlorohydrate Quatemιum-26. -27, -53, 62. -72 Aluminum starch oαeπvlsuccinate Aluminum -zircomum-glycine powder Rapeseedamidopropyl benzvldunomum chloπde Boron mtπde Sage (Salvia officinalis) extract Rapeseedamidopropyl epoxypropyi dimomum C20-40, C30- 50, C40-60 alcohols Totmentil (Potenttlla erecta) extraα chloπde Calαum stearate Zirconium chlorohvdrate Silica, colloidal Cellulose gum Sorbuan caprvlate Dihvdroabietvi behenate
Antiseptic N-Sova- 3-amιdopropvl)-N N-dimethvl-N -e_vl Dusostearvl maiate
Aluminum PCA ammonium ethvl sulfate Dioctvl sebacate
Azadirachta indica extraα Soyethyl moφholimum ethosulfate Distarch phosphate
2-Bromo -2 nitropropane- 1 -dιol Soyethyldunonium ediosuifate Ethylcellulose
Calendula amurrensis extract Stearalkomum chloπde Gellan gum p-Chloro-m-cresol Stearaπudopropvl benzvl dimomum chloπde Hydrogenated jojoba oil
Clove (Eugenia carvophvllus) oil Stearamidopropvl ethvldunonium ethosulfate Isocetyl alcohol, I palmitate
Crataegus cuneata extract Steartπmo um chloπde Isopropvl isostearate
Dichlorobenzvl alcohol Isostearvl erucate. 1 isostearate N-Slearvl-(3-amιdopropvl)-N,N-dιmethvl-N-ethvl
Entada phaseoloides extract Isostearvl neopentanoate ammonium ethvi sulfate
Eucalvptus (Eucalyptus globulus) extract Wheat geπnamidopropvl ethvldunomum ethosulfate Maltodextπn
Golden seal (Hvdrastis canadensis) root extraα Methylcellulose
Hexachlorophene Astringent MicrocTvstall e cellulose
Melia australasica. M azadirachta extraα Octyl palmitate
Aluminum citrate, A lactate
Methvl salicvlate Octvldodecvl mvπstate
Astragalus sinicus extract
Orange (Citrus aurant m dulcis) peel extraα bis-Octvldodecvl stearovl dimer dilinoleate
Astrocaiyum murumuni. A tucuma extraα
Oxvqumohπe sulfate Octvldodecvl stearovl stearate
Azadirachta indica extract
Pfaffia pamculata extract Oleyl oleate
Azelaπude MEA
Potassium abietovl hvdrolvzed collagen PEG -20 -75, -150, -240 -350
Bearberrv (Arctostaphvlos uva-ursi) extraα
PVP-iodine Polvdipemeπe
Birch (Betula alba) leaf extract
Silver nitrate Poivetbvlene. P. micronized
Catalpa kaemptera extract PTFE
Sodium salicvlate Celastπis pamculata extraα PVP
Stercu a platamfolia extract Coc nea indica extract Sorbitol
Tea tree ( Melaleuca alternifolia) oil Coffee (Coffea arabica) bean extract Svntheuc wax
Tormentil (Potentilia erecta) extract Euphrasia officinalis extract Tapioca dextnn
Xanthozvlum bungeanu extract Euterpe precatoπa extraα Tπdecvl behenate. T neopentanoat.
Evening primrose (Oenothera bienms) extract
Antistat Tπdecvi stearovl stearate
Gentian (Genuana lutea) extract
Acetamide MEA Tπsodium HEDTA
Geranium maαilatum extract
Acetamidopropvl tπmonium chloπde Grape (Vitis vmifera) leaf extraα Biol. polvmer
6-<N-Acetvlamιno -oxvhexvltπmonιum chloπde Henna (Lawsoma uieπnis) extract Distarch phosphate
Alkvl dunethvl betaine Hierochloe odorata extract Dog rose (Rosa canina) seed extract
Babassuamidopropalkomum chloπde Honeysuckle (Lonicera capπfolium) extraα Hydrogen peroxide
Behenamidopropvl ethvldunonium ethosulfate Hops (Humulus lupulus) extract Kojic aαd
Behenamidopropvl hvdroxvethvl dunomum chloπde Horsetail extract Muiberrv (Moms mgra) extract
Carboxvmethvl chitiπ Hypeπcam perforatum extract Sanguisoibae root extraα
Cetethvl mo hohmum ethosulfate Ivy extraα
Cetπmomum chloπde Jumperus communis extraα Botanical
Chitin Kadsura heteiiloca extract Acaαa
Chitosan Kola (Cola acuminata) extract Acaαa farnesiaπa extract
Cocamidopropvl ethvldunonium ethosulfate Ladv's mande (Alchemilla vulgaπs) extraα Agπmonv (Agπmoma eupatoπa) extract
Cocodimomum hvdroxvpropvl hvdrolvzed πce Lemon (Citrus medica limonum ) extract, peel extraα Alder (Alnus fiπnal extract protein Lemon bioflauonoids extract Alfalfa (Medicago saπva) extract Cocodimomum hvdroxvpropyl hvdrolyzed sov Lysunachia foenum-graecum extraα Algae (Ascophyilum nodosum) extract protein Magnolia spp extraα Algae (Lnh otammum caicarum) extract Dimethicoπe hvdroxvpropvl tπmomum chloπde Mauntia flexosa extract Aloe baibadensis. A.b extraα Dunethvl behenamine D cocamine Maximil aπa regia extract Aloe capensis extraα Dunethvl palmitamine D soyamme Melaleuca uncinata. M wilsomi extraα Alpme Vero ca extraα Dunethvl tallowamine Melia australasica extract Althea officinalis extract Dioievlamidoethvl hvdroxyethylmomum Nettle (Urtica dioica) extract Angelica archangeiica extract methosulfate Oak (Ouercus) bark extract Anise (Pimpinella amsum) extract Dipalmitovlethvl hvdroxvethvlmonium methosulfate Ocimum basiiicum. O santum extraα Apple (Pvπis malus) extract N-Dodecvl-N N dιmethvl-N-(dodecvl acetate) Palmetto extract Apπcot (Prunus armemaca) extract ammonium chloπde Passion flower ( Passiflora lauπfolia) fruit extract Arnica montana extract Erucamidooropvl hvdroxvsultaine Plantain (Plantago major) extract Artemisia captllaπs extraα Glvcerv l monopvroglutamate Polvgoπum multiflorum extract Aπtchoke I Cv nara scolvmus) extract Hvdroεenaied tallowamine oxide Pterocarpus marsupianus extract Asatenda I Ferula assa toetida) extract Isoste irjmiunprom I Raspbem ( Rubus I extract Aiusjrum .eboldi extract Functions
Asparaaus oitiunahs extract Cucumber (Cucumis sativus) extract Jasmine (Jasminum otficinale) extract
Astraealus siπicus extract Cvpress (Cupressus sempervirens) extract Job s tears (Coix lacryma jobu extract
Avens iGeu πvalei extract Dandelion (Taraxacum otficinale) extract Jojoba (Buxus chinensis) seed powder
Avocado I Persea -ratisxima) extract Date (Phoenix dactvliterai extract Junipems commu s extract
Balm mint I Melissa otticinalisl extract oil extract Dead Sea Mud Salts Kelp (Macrocvstis pyπfera) extract
Banana (Musa sapieπtumi extract Doe rose (Rosa caniπai hips extract Kiwi (Actimdia chinensis) fruit extract seed oil
Barlev iHordeu vulearei extraα Dver s broom extract Kola (Cola acuminata) extract
Basil (Ocimum basilicumi extract Eleuthero ainseng ( Acanthopanax senticosus) Krameπa tπandra extract
Bearberrv i Arciostaphvlos uva ursi ) extract extract Lady s mantle (Alchemilla vulaaπs) extract
Bee pollen extract Elm (Ulmus campestπsl extract Ladv s Thistle (Silvbum maπanumi extract
Beet l Beu vuleaπsi extract Eucalvptus ( Eucalvptus globuius I extract Laurel (Lauras nobilis) extract
Betaalucun Eucalyptus globuius oil Lavender (Lavandula anaustitoha) extract water
Bilberrv I Vjccinium mvrtillusi extract Eucommia ulmoides extract Lemon (Citrus medica limonum) exu-act juice
Biollavonoids Euphrasia officinalis extract extract peel extract
Birch I Betula alba I bark extract leaf extract Eventnc pπmrose (Oenothera bieπnis) extract oil Lemon biotlauonoids extract
Birch I Betula plutvphv lla japomca) extract Everlastinβ (Helichrvsum arenaπum I extract Lemongrass (Cymbopoaon schoenanthus) extract
Bitter oranae I Citrus aurantium umara I extract Fennel (Foemculum vulgare) extract Leopard flower ( Belamcanda chinensis! root extract
(lower extract peel extract Fenugreek extract Lettuce ( actuca scaπola sativai extract Black Lohosh (Cimiutuaa racemosai extract Fermented πce (Orvza sauva) extract Licence iGlvcvrrhiza glabra) extract Blac currant ( Ribes n ruml extract Fem (Drvoptens tilix Mas) extract Lilac (Svππga vulgaπs) extract Black henna extrau Fig (Fi us caπca) extract Linden (Tilia argenteai extract BUck poplar I Populus nisrui extract Fir needle extract Linden iTilia cordatai extract water Black walnut (Julians πiarai extract Fumitorv ( Fu aπa officinalis I extract Loquat I Eπobotrva japomca i leat extract Bladderwrack ( FULUS vesiculosus) extract Gardenia tloπda extract Maidenhair tern extract Boraee i Borαso otliciπalisi extrau Garlic I Allium sanvumi extract Buckthorn i Franaula alnus > extrau Ge dium caπilaaineum Maenolia kobus extract Burdock I .rctmm lappai extract Gentian iGennana lutea) extrau Mallow extraα Burdock I Arciium minusi root extract Geranium maculatum extract Mandragora otfiαnarum extract Bumet extract Ginger root extract Mannan
Butcherbroom i Ruscus aculeatus) extract Ginkgo biloba extract Mangold Cabbage rose I Rosa -entiloliai extract Ginsena ( Panax ginseng) extract Maπne silts Calamus l Aςorυs calamus I extract Glvcyrrhetinic acid Matπcana (Chamomilla recutitai xtract Calendula officinalis extract Glvcyrrhizic acid Meadowsweet (Spiraea ulmaπai extract Caper (Cappaπs spinosai extract Glvcvrrhizin ammoniatcd Melon (Cucumis elo) extrau Capsicum trutesceπs extrau C t oleoresin Golden seal ( Hvdrastis canadensisl root extract MEA iodine Carawav i Camm can 11 extract Goldthread (Coptis japomca I extract Mistletoe i Viscu album i extract Carraeeenaπ iCliondrus πspusi Gυtu kola extrau Mu woπ I Artemisia pπncepsi extract water Carrot iDaucus (.arotai extract Grape iVins vimterai distillate extract Mulbem i Morus alba) root extract Carrot (Dauι.us ςarσta satnai oil Grape I Vms vimterai leat seed extract Mulberrv i Morus bombvsisi root extract Cassia auπculata extrau Grape skin extrau Mushroom extract Celandine iChelidonium ma usi extract Grapefruit iCitrus grandisi peel extract Mvrrh lCommiphora mvrrha) extract Chamomile i Anthemis πobilisi extract oil Green bean i Phaseolus lunatusi extract Nastu um extract Chaparral i Laπea mexicanu) extract Ground hederacea) extract Neroh extract Chem i P unus speuosai leat extract Guaraπa i Paullinia cupaπai extract Nettle ( 'πica dioicai extrau Cherrv bark C b -xtrau Haφaaopnvtum procumbeπs extract Oak (Quercusi bark extract Chestnut iCastanea sam ai extrau Havflower extract Oak root extract Chinese niDiscus i Hibisms rosa sinensisi extract Hazel (Corvlus avellaπai nut extract Oat i As ena sauva) bran bran extract flour protein Chlorella suljuns extract Henna (Law sonia mermisi extract Oat flower Cimiciru-a loetida rhizome extract Hespeπdin H methvl chalcone Olive lOlea europa) extract leat extract Cinchona su-ςirunra extract Hibiscus sabdaπtfu extract Onion ( Allium cepa) extract Citroflavonoiu water soluble Hibiscus svπacus extract Orange blossom extract Citrus biollavonoid complex Hiah beta jlucan barlev flour Orange I Citrus aurantium dulcis I flower extract Clarv extract Honeysuckle ( onicera capπtolium ) extract peel extract
Clove lEuaenu carxophvllus i extract Honeysuckle I Lonicera japomca I leat extract Pansv ( Viola tπcolor) extract Clover I Tπtolmm pratensei extract Hops ( Humuius lupulus I extract Papava iCanca papavai extract Cmdium otficinale rhizome extract C o water Horse chestnut (Aesculia hippocastanum) extract Parslev (Camm petroselinum) extrau Cotfee (Corfeα arabicai bean extract Horseradish (Cochleana armoraciai extract Passion flower (Passiflora lauπfoliai fruit extract Colloidal oatmeal Horsetail extract Passionflower (Passiflora iπcamatai extract
Coltsfoot (Tussilaao tartarai leat extract Houttuv a cordata extract Pea ( isum sativum ) extract Comtrev i Svmphvium uitn-inalei leat extrau Hyacinth ( Hvacinthus oπeπtalis ) extract Peach (Prunus persica I exu-act leat extract Conduranao extract Hydrototvl (Centella asiaticai extract Pelareoπium capitatum extract
Coneflower i Echinacea anaustitohai extract Hydrolvzed oat protein sov tlour Pel torv ( Paπetaπa officinalis) extract Coralhna orficinalis Hypeπcum pertoratum extract Penπvroval i Vlentha pulegiumi extract Corchorus oluoπus extrau Hvssop I Hsssopus otficinalisi extract Peoπv ( Paeonia albaflorai extract Coπαnder i Coπandrum sativ urn I extrau Indian cress (Tropaeolum ajus) extract Peonv I Paeonia obovatai root extract Com iZea mavsi cob powder silk extract Isodoms Japontcus extract Peppermint ( entha pipeπta) extract oil Com poppv i Papaver rhoeasi extract Ivy extract Cornflower I Centaurea cvanus I extract Peπlla ocvmoides extract Japanese anaehca (Angelica acutiloba) extract Peπwinkle i Vinca minor) extract Couch i Agropvroπ renensi rass water Crataeaus monogiπa extrau PEG-80 jojoba acid/alcohol Japanese hawthorn (Crataeaus cuneata) extract Cπthmum maπtimum extract PEG- 120 jojoba acid/alcohol
CAMPO Siddha Herbs Extracts
Jothi-Pul (Glow-grass) Siddha Extract tor High content bio-available CAMPO RESEARCH
Natural Radium for anti Karposi Sarcoma Skin Treatment. Level 36, Hong Leong Building,
Roma-Maram (Hairy Tree) Siddha Extract forANTI-SENSE DNA 16 Raffles Quay Singapore 0104
Topical applications (or HIV + Lymph-nodes Tel (65) - 7653292 Full Colour Fax (65) - 7653293 Siddha Extracts for post-Chemotheraphy Skin-Damage Treatment PC - Video Teleconferencing (65) 7653292 - For Tech Assistance Functions
Pfaffia pamculata extract Wheat (Tπticum vulgare) extract, protein Phyoc acid
Phello endron amurense extract Wheat (Tπncum vulgare) germ extract Potassium aspaπate
Phospholipids Wheat bran lipids Sodium aspaπate
Pimento (Pimenta otficinalis) extract White ginger (Hedvchium coronanum) extract Sodium dihydroxyethylglycinate
Pine (Piπus svlvestπsl cone, needle extract White nettle (Lamium album) extract Sodium hexametaphosphate
Pineapple (Ananas sativus i extract Wild agnmonv ( Potenulla anseπna) extract Tetrahydroxypropyl ethylenediaπune
Plantain (Plantago major) extract Wild cherry (Prunus serouna) bark extract Tetrasodium EDTA
Pollen extract Wild indigo (Bapttsta nnctoπa) Tπpotassium EDTA
Pongamol Wild marjoram (Onganum vulgare) extract Tπsodium EDTA. HEDTA
Pona Cocos extract Willow (Salix alba) bark extract, extract
Pueraπa lobota extract Willow (Salix alba) leat extract Cell stimulant
Queen ot the meadow extract Witch hazel (Hamamelis virgiπiaπa) extract Aesculus chinensis extract
Quillaja saponana extract Yarrow ( Achillea millefo um) extract Artemisia apiacea extract
Quince ( Pvrus cvdoniai seed extract Yeast (Saccheromyces cerevisiae I extract (Faex) Astrocarvum muru. A tucuma extract
Quinoa (Chenopodium quinoai extract Yucca vera extract Bactns gastpaes extract
Raspbeπ . ( ubus i extract Zanthoxylum pipentum extract Borojoa sorbi s extract
Rauwolfia (Serpentmai extract Zedoary (Curcyma zedorana) oil Calendula amurrensts extract
Red clover Chrysanthemum monfolium extract
Re mannia chinensis extract Buffer Coccinea indica extract
Restharrow lOnonis spinosai extract Ammonium carbonate. A phosphate Comfrey (Symphytum o ficinale) leaf extract
Rhododendron chrv santhum extract Calcium hydroxide. C phosphate Condurango extract
Rhodophvcea extract Citπc acid Dandelion (Taraxacum officinale) extract
Rhubarb ( heum palmatuml extract Ethanolamine HCl Echitea glauca extract
Rice (Orvza sativai bran extract Glvcine Equisetum arvense extract
Rice fattv acid Phosphoπc acid Eucalvptus (Eucalyptus globuius) extract
Rose (Rosa multiflora) extract Potassium phosphate Euphotonum forainei extract
Rosemarv ( Rosmaπnus orficinalis) extract Potassium sodium tartrate Euterpe precatona extract
Rubta tmctonim extract Sodium acetate. S citrate Ficus racemosa extract
Safflower i Carthamus tinctoπus I extract Sodium lactate. S phosphate Glycoproteins
Sage (Salvia orficinalis) extract, water Succinic acid Hierochloe odorata extract
Sambucus mgra berrv extract, extract Tromethamine Horse chesmut (Aesculia hippocastanum) extract
Sandalwood I Santalum album ) extract Inga edulis extract
Sanguinana canadensis extract Carrier Kadsura heteliloca extract
Ligustrum lucidum extract
Saponana orficinalis extract Acrvlates copolymer. spheπcal powder Lysimachia toenum-graecum extract
Sasa veitchn extract Arginine Maunua tlexosa extract
Saxifraga sarmentosa exu-act Caprv c capπc tnglyceπde Maximilliana regia extract
Scabtosa arv ensis extract Caprvlic/capπc/lauπc tnglyceπde Melaleuca bracteata. M svmphyocarp extract
Scutellana baicatensis root extract Caprylic/capnc linoleic tnglvceπde Nelumbium speciosum extract
Silk extract Caprvlic/capπc/oleic tπglyceπdes Ocimum basiiicum extract, O santum extract
Silver fir I Abies pectinatai extract Ceteareth-20 Paulownia impeπalis extract
Sisal (Agave πgidai extract Coconut t Cocos nuctfera) oil Pfaffia spp extract
Slippery elm extract Cyclodextnn Pterocarpus marsupianus extract
Soapberrv iSapmdus mu urossl extract Dipropylene glycol Rubus thunbergu extract
Sophora a extract Glycervl caprvlate, G caprvlate caprate Selinum spp extract
Sophora root extract Hvdrated silica Shorea robusota extract
Sophora japomca extract Uposomes Xanthozvlum bungeanum extract
Soybean iGlvcine sojai extract Magnesium silicate
Sov (Glvcine soiai germ extract, protein, sterol Methvl propanediol Cleansing
Spearmint I Mentha s iπdis I extract, oil PEG-8/SMDI copolvmer Birch ( Betula alba I leaf extract
Spinach (Spinacia oleraceai extract Potassium chlonde Lemongrass iCvmbopogon schoenanthus I extract
Spiraea ul ana extract PPG-12/SMDI Copolvmer Oat ( Avena sativa) bran extract
Sunflower i Helianthus annuus) seed extract PPG-51/SMDI Copolvmer Passion flower (Passiflora lauπfolia) fruit extract
Sweet almond i Pmnus amvgdalus dulcis) extract Propylene carbonate. P glycol Witch hazel (Hamamelis vitginiana) extract
Sweet cherrv (Prunus avium) extract Serum albumin Yarrow (Achillea millefolium) extract
Sweet cicelv I Anthπscus ceretolium) extract Sodium carboxymethvl beta-glucan
Sweet clov er I Me lotus otficinalis I extract Sodium chlonde Conditioner
Sweet violet ( Viola odoratai extract Sodium magnesium silicate Acetamide MEA
Sweπia chirata extract Tapioca dextπn 6-(N-Acetvlamιnoι-4-oxvhexvltnmonιum chloπde
Tea (Caπullia sinensis) extract Acrvlamidopropyltnmonium chloπde/ acrvlamide
Thistle (Chicus benedictus I extract Chelators copolymer
Thvme (Thvmus vulgaπsi extract beta-Alanine diacetic acid Adipic acid/dimethvlaminohvdroxvpropyl
Tomato ( Solanum Ivcopersicum) extract Calcium disodium EDTA diethylene tπamine copolymer
Tormentil ( Potenulla erectal extract Disodium EDTA, -copper AMP-isostearovl hvdrolvzed wheat protein
Tuberose (Po anthes tuberosai extract EDTA Apπcot ( Prunus armemaca) kernel oil
Turmeπc I Curcuma longa) extract HEDTA Behenalkomum chlonde
Valeπan i Valeπana orficinalis ι extract Malic acid Behenaπudopropyl dihvdroxypropyl dimomum
Walnut (Juglans regial extract, leaf extract Monostearvl citrate chloπde
Water Lily (Nvmphaea alba I root extract Pentasodium pentetate Behenaπudopropyl ethyldimomum ethosulfate
Watercress i Nasturtium otficinale I extract Pentetic acid Behenamidopropyl PG-dimomum chloπde
CAMPO Siddha Herb Extracts CAMPO RESEARCH
CAMPO Rainforest Herb Extracts & Oils Level 36, Hong eong Building,
CAMPO Australasian Herbs & Tea Tree Extracts 6 Raffles Quay, Singapore 0104
Tel: (65) - 7653292 Full Colour Fax: (65) - 7653293
CAMPO Chinese & Japanese Herb Extracts PC - Video Teleconferencing (65) 7653292 - For Tech. Assistance.
1.12 Cosmetic Bench Reference 1996 Functions
Behenamidopropy Idimethv 1 amine behenate Hydrolyzed sweet almond proiem Polymethacrylamidopropyltπmomum chlonde
Behenamine oxide Hydrolyzed wheat protem PVP copolvmer Polyoxyethylene dihvdroxypropyl linoleamuuum
Behenovl PG-mmomum chloπde Hydrolyzed wheat protein polvsiloxane polvmer chlonde
Behenvl betaine Hydroxycetvl hvdroxyethvi dunomum chloπde Polyquateπuum-2, -5, -6, -11, -16
Benzyltnmomum hvdrolvzed collagen Hydroxyproline Polyquateπuum-17. -18. -24, -29, -44
Canolamidopropvl betaine Hvdroxypropyl chitosan Potassium dimethicone copolvol panthenyi
Capramide DEA Hydroxvpropyl guar hvdroxvpropyltπmomum phosphate
Caprv c/capπc/lauπc tπglyceπde chlonde Potassium lauroyl collagen ammo acids
Caprvlyl pvrrolidone Hydroxypropyl-bis-isostearyaraidopropyldimoiuum Potassium lauroyl hydrolyzed sov protein
Cassia auπculata extract chlonde Potassium laurovl wheat amino aαds
Cetamine oxide Hydroxypropyl bis-stearvldimomum chlonde Potassium stearovl hydrolyzed collagen
Cetearalkomum chlonde Hydroxvpropvltπmonium gelatin PPG-5 lanolin alcohol ether
Chitosan PCA Hydroxypropyltπmonium hydrolyzed keratin PPG-9 dieihylmoniura chloπde
Citnc acid H h. silk PPG -20 lanolin alcohol ether
Cocamidopropyl dimethylamine. C d lactate, C d Hydroxvpropyltπmonium hydrolyzed wheat Proline proptonate protein Propylene glycol stearate Cocamidopropvl dimethvlaminohydroxypropvl Isopropyl hvdroxvbutvramide dimethicone PVP/dimethiconylacrylate/polycarbamyl/ hydrolvzed collagen copolvol polyglvcol ester Cocamidopropvldimomum Isopropvl lanolate PVP/dimethvlam oethylmethacrv late copolymer hvdroxvpropvlhvdrolvzed collagen Isostearamidopropvl betaine. I dimethvlamtne PVP/dimethvlaπunoethvlmethacrylate/ Cocamidopropvl ethvldimomum ethosulfate Isostearamidopropvl dimethvla ine gluconate polycarbamvl/poivglvcol ester Cocamidopropvl PG-dimonium chloπde. C Pc Isostearamidopropvl dimethvlamuie givcαlate PVP hvdrolvzed wheat protein copolvmer phosphate Isostearamidopropvl dimethvlamine lactate Quatemιum-22. -26. -33, 61, -62. -70, -80 Coco-morpholine oxide Isostearamidopropyl ethvldimomum ethosulfate Quatemιum-76 hvdrolvzed collagen Coco/oleamidopropvl betaine Isostearamidopropvl laurvlacetodimonium chloπde Rapeseedamidopropvl benzvldimonium chloπde Cocodimomum hvdroxvpropvl hvdrolvzed hair Isostearamidopropvl morpholine. I m lactate Rapeseedamidopropyl epoxvpropyl dimomum keratin Isostearamidopropyl morpholine oxide chlonde Cocodimomum hvdroxypropyl hydrolvzed πce Isostearamidopropvl PG-dimonium chlonde Rapeseedamidopropyl ethvldimomum ethosulfate protein Isostearaminopropalkomum chlonde Rice peptide Cocodimomum hvdroxvpropyl hvdrolvzed silk Isostearvl hvdrolvzed animal protein Rictπoleamidopropvl-dimonium ethosulfate Cocodimomum hvdroxvpropyl hvdrolvzed sov Isostearvlamidopropyl dihvdroxvpropvl dimomum Ricinolea idopropyl betaine protein chlonde Ricinoieamidopropvl dimethvlamine lactate Coconut alcohol Lactoglobolin Ricinoleamidopropvl ethvldimomum ethosulfate N-Cocovl-(3-amιdopropyl)-N,N-dιmethvl-N-ethvl Lauramidopropvl dimethvlamine Ricinoleamidopropvltnmomum chloπde ammonium ethvl sulfate Lauramidopropvl PG dimomum chloπde. 1 Pc Ricinoleamodopropvltπmonium ethosulfate Collagen phthalate phosphate Silicone quaternιum-3 .
Dibehenvl/diarachidvl dimomum chloπde Lauramine oxide Sdk amino acids Dibehenvldimomutn chlonde Lauroampho PG-glycinate phosphate Sodium/TEA-laurovl collagen amino acids Dicetvldimonium chloπde Laurovl hvdrolvzed collagen. L h elastin SodiuπvTEA-laurovi hvdrolvzed keratin Didecvldimomum chloπde Laurovl silk ammo acids Sodium/TEA-lauroyl keratin amino acids Dihvdroxvethvl cocamine oxide Laurvl methvl gluceth- 10 hvdroxvpropvl- Sodium citrate Dihvdroxvethvl dihvdroxvpropvl stearmonium dimonium chloπde Sodium cocovl hvdrolvzed sov protein chloπde Laurvl phosphate. L pvrrolidone Sodium hvdrogenated tallow dimethvl glvcinate Dihvdroxvethvl tallow glvcinate Laurvldimonium hvdroxvpropvl hvdrolvzed Sodium laurovl collagen, keratin ammo acids Dihvdroxvethv l tallowamine oxide collagen, keratin sov protein Sodium laurovl wheat amino acids Dilaurv 1 acetvl dimomum chloπde Unoleamidopropvldimethvlamine Sodium stearoamphoacetate Dilinoleamidopropvl dimethvlamtπe Milk ammo acids Soluble keratin, wheat protein Dimethyl hydrogenated tallowamine Milk protein (Lactis protetnum) Sovamide DEA Dimethvl lauramine D 1 isostearate Mvnstalkonium chloπde Soyamidopropvl benzvldimonium chloπde Dunethvl mvπstamine sovamine. stearamine Mvπstamidopropvl beta e. M dimethvlamine Sovamidopropyl betaine S dimethvlamine Dimethvlamidopropvlamuie dimerate Mvππmonium bromide Sovamidopropyl ethvldimomum ethosulfate Disodium hvdrogenated cottonseed glyceπde Oat (Avena sativa) protein Soyethvl morpholinium ethosulfate sulfosuccmate Oleatmde Soyethvldimomum ethosulfate Disodium laureth sulfosuccmate Oleamidopropvl betaine. O dimethvlamuie Stearamtde MEA Disodium lauroamphodiacetate Oleamidoprαpyl dimethvlamine hvdrolvzed Stearaπudoethvl diethvlamine ethanolamine Distearvldimomum chloπde collagen Stearamidopropyl benzyl dimomum chloπde Ethvl ester ot hvdrolvzed keratin Oleamidopropvlamine oxide Steaian udopropyl cetearvl dimomum tosvlate N-Ethvlether-bis- 1 4-(N-ιsostearvlamιdopropvl- Olea ine Stearamidopropvl dimethvlamine stearate
N N-dimethvl ammonium chlo Oleamuie oxide Stearamidopropyl ethvldimomum ethosulfate Glutamic acid Oleovl sarcosine Stearamidopropvl morpholine lactate Glvcervl collagenate Olevl betaine Stearamidopropvl PG-dimomum chloπde Glvαne Olevl dimeihvlamidopropvl ethonium ethosulfate phosphate
Guar hvdroxvpropvltπmonium chloπde Palmitamidopropvl betame Stearamine oxide Henna (Lawsonia inermis) extract Palmitamidopropvl dimethvlamine Steardtmomum hvdroxvpropvl hydrolvzed Palmitamine, P oxide Hvdrogenated tallowamine oxide collagen, keratin
Pantheπvl hvdroxypropyl steardtmonium chloπde Hvdrogenated tallowmmonium chloπde Steardimonium panthenoi PEG-, milk solids Hvdrolvzed conchioπn protein Stearovl amidoethvl diethvlamine PEG-2 oleammonium chloπde Hvdrolvzed egg protein Steattnmomum bromide PEG-3 lauramine oxide Stearvl dimethicone Hvdrolvzed extensin PEG-5 stearvl ammonium lactate Tallowamidopropyl dimethvlamine Hvdrolvzed tibronecun PEG-15 cocomonium chloπde Tetramethvl tπhvdroxv hexadecane Hvdrolvzed fish protein PEG- 15 cocopolvamtne TEA-cocovl hvdrolvzed collagen Hvdrolvzed keratin PEG-15 tallowmonium chloπde Trachea hvdrolvsate Hvdrolvzed lactalbumin PEG-27 Tπcetvlmomum chlonde Hvdrolvzed milk protein PEG-40 Tπdecvl salicvlate Hydrolvzed oaib PEG-85 lanolin Tnethonium hvdrolvzed collagen ethosulfate Hvdrolv zed rc-tii-uhn PEG -7000 Wheat germamidopropulkonium chloπde "r tein Polvdimeihicone copolvol Wheat germamidopropvl dimethvlamine lactate Functions
Wheat germamidopropyl ethyldimo um Disodium lauroamphodiacetate TEA-PEG-3 cocamide sulfate ethosulfate Disodium lamoamphodipropionate Undecylcnamidopropyl betame Wheat peptide Disodium lauryl sulfosuccmate Yeast powder, deproteinated Disodium myπstamido MEA-sulfosuccinate Disinfectant
Disodium nonoxynol-10 sulfosuccmate Benzalkomum chloπde
Coupling a ent Disodium oteamido PEG-2 sulfosuccmate Chlorophene
Acetyl monoethanotamine Disodium PEG -1 cocoamido MIPA-sulfosuccinate Didecyldimomum chloπde Butyloctanol Disodium πc oleamido MEA-sulfosuccinate Mynstalkomum sacchannate Myreth-3 Disodium tallowtmmodiproptonate Shiko n Oleyl alcohol Dodecylbenzene sulfonic aαd Sodium capryloamphoacetate PPG-lO butanediol Dodoxyπol -6, -9 Tea tree (Melaleuca alteπufolia) od PPG-10 cetvl ether Isopropylam e dodecylbenzenesulfonate p-Tertaiylphenol PPG-10 olevl ether Isostearamidopropyl betame PPG-15 stearyl ether Isosteareth-6 carboxylic acid Dispersant PPG-22 butyl ether Isostearoamphopropionate Alkylated polwmylpyrrolidone PPG-23 oleyl ether Isostearyl hydroxyethvl lmidazoline C20-40, C3O-50, C40-60 alcohols PPG-50 olevl ether Lauramidopropylaπune oxide Castor (Ri nus commums) oil Tπdeceth-7 carboxylic aαd Laureth- 11 Ceteareth-20
Lauroampho PG-glyciπate phosphate Cetyl PPG-2 ιsodeceth-7 carboxylate
Deπaturant
Lauryl glucoside. L. phosphate Cholesteryl behenyl/octyldodecyl lauroyl glutamate
Bruαne sulfate
Magnesium laureth sulfate. M. laurvl sulfate Decaglycerol monodioleate
Denato um benzoate. sacchaπde
Magnesium PEG-3 cocamide sulfate Diisocetvl dodecanedioate
Nicotme sulfate
MEA-dodecylbenzenesulfoπate Diisosiearyi adipate
Sucrose oαaacetate
MEA-laureth sulfate Dimethicone copolvol methvl ether
Thymol
MEA-laurvl sulfate Dioctyldodecvt dimer ddinoleate
Dental powder MIPA-lauryl sulfate Dioctyldodecvi dodecanedioate
Dicalαum phosphate Myristamine oxide Ethyl hydroxymethyl oleyl oxazoiine
Silica Mynsuc aαd Glyceryl caprylate. G. caprylate/caprate
Sodium monoQuorophosphate Nonoxynol-10 Glyceryl dusostearate
Stannous Quonde Olcoamphohydrox vpropy Isulfonate Hydrogenated castor oil. H. lecithin
Oleth-12, -15 Hydrogenated tallow glycerides
Deodorant Oleyl betame Isobutylene/MA copolymer
Abietic aαd Palmitamidopropvl betaine Isocetyl alcohol
Azadirachta indica extract PEG-10 glycervl stearate Isopropyl C12-15-pareth -9-carboxyiate
Chlorophvllm-copper complex PEG- 15 glyceryl stearate Isostearyl neopemanoate
Eugenia ja bolana extract PEG-25 glyceryl isostearate Lanolin aαd
Farnesol Potassium cocoyl hydrolyzed collagen Laureth-4, -6. -16
Fermented vegetable Sodium caproamphoaceiate Melanin
Mauπtia tlexosa extract Sodium cocoamphoacetate Nonoxynol-2. -18. -20, -30, -40
Salvia miltiorrfuza extract Sodium cocoamphopropionate θctoxynol-5. -10
Sodium aluminum chlorohydroxy lactate Sodium cocomonoglyceπde sulfate Oαoxynol 16. 0. 40. 70
Spondias amara extract Sodium cocoyl hydrolyzed soy protein θctyldodeceth-5
Tπethyl citrate Sodium cocoyl lsethionate Octvldodecyl/dtmethicone copolvol citrate
Zinc phenol sulfonate. Z. παnoleate Sodium C12-15 pareth-25 sulfate Oleth-40
Sodium C14-16 olefin sulfonate Olevl alcohol
Depilatory Sodium C14-17 alkvl secsul fonate PEG-5 castor od. glyceryl sesquioleate
Baπum suitϊde Sodium deceth sulfate PEG-6 beeswax Beeswax, oxidized Sodium decyl diphenyl ether sulfonate PEG -8 SMDI copolvmer Calcium thioglvcolate Sodium dodecylbenzenesulfonate PEG-9 castor od. oleate. stearate L-cysteine HCL Sodium dodecyidiphenyl ether sulfonate PEG-10 dioleate. stearamine Potassium thioglvcolate Sodium lodate PEG- 12 beeswax Sodium thioglvcolate Sodium iaureth-2 sulfate PEG- 12 glyceryl dioleate. laurate Thioglyceπn Sodium laureth- sulfate PEG- 15 castor oil
Sodium iaureth-7 sulfate PEG-20 almond giyceπdes
Detergent Sodium laureth- 12 sulfate PEG-20 glyceryl isostearate
Ammonium laureth sulfate Sodium laureth- l3-carboxylate PEG-20 sorbitan tπisosterate Ammomum laurvl sulfate Sodium laureth sulfate PEG-25 castor od Capramtde DEA Sodium launminodipropionate PEG-30 dipoiyhydroxystearate
Cocamidopropvl dimethvlamine lactate Sodium lauroamphopropionate PEG-40 hvdrogenated castor od PCA isostearate Decyl glucoside Sodium lauroyl methvl alamnate PEG-60 shea butter glycendes Decvltetradecelh-25 Sodium lauryl phosphate, S.l. sulfate Poloxamer 101. 122, 181, 182. 184 DEA lauryl sulfate Sodium lauryl sulfoacetate Polyglyceryl-2 sesquusostearate Diamyi sodium sulfosuccmate Sodium methyl oleovl laurate Polyglyceryl -3 diisostearate, oleate Dicyclohexyi sodium sulfosuccmate Sodium methyl cocoyl taurate Polyglyceryl-5 distearate Diisobutyl sodium sulfosuccmate Sodium methvUaurovltaurate Polyglyceryl-6 mixed fattv acids Disodium caproamphodiaceta te Sodium methvlnaphthalenesulfonate Polyglyceryl- 10 diisostearate, distearate Disodium caproamphodtpropionate Sodium myreth sulfate Polyglyceryl-10 decaoleate Disodium caprvioamphodiacetate Sodium myπstvl sulfate Polyhydroxysteaπc acid Disodium capryloamphodipropionate Sodium octyl sulfate. oleyl sulfate Polysorbate 40. 80 Disodium cetearyl sulfosuccmate Sodium POE alkyl ether acetate Potassium poivacrvlate Disodium cocamido MEA-sulfosuc nate Sodium tπdeceth-7 carboxylate PPG -3 PEG-6 oleyl ether Disodium cocamido MIPA-sulfosuccmate Sodium tπdeceth sulfate PPG-9 diethvlmomum phosphate Disodium cocoamphodipropionate Sodium tndecvi sulfate PPG-12/SMDI Copolymer Disodium deceϋi -6 sulfosuccmate Steareth-ll, - 0 PPG-15 stearvl ether Disodium isodecvl sulfosuccmate TEA-dodecvlbenzenesulfonate PPG-25, PPG-40 diethvlmomum chloπde Disodium lauramido MEA-sulfosuccinate TEA-laureUi sulfate PPG-51/SMDI Copolymer Disodium lauramido PEG-2 sulfosuccmate TEA-laurvl sulfate PVP/eicosene copolymer Disodium laureth sulfosuccmate TEA-palm kernel sarcos ate PVP/hexadecene copolymer
1.16 Cosmetic Bench Reference 1996 Functions
Rapeseed oil uhoxvlated high enicic acid Cetyl stearyl octanoate Dihvdroαbietvl behenate
Riunolevl alcohol Ch (Salvia hispαmcα) oil Dihvdroxvethvl tallowamine oleate
Sodium ceteth 13-carboxvlαte Cholesteπc esters Diisυbutvl adipate
Sodium liBnosultonate S poivmethacrylate Cholesterol Dnsocetvl adipate dodecanedioate
Sodium polvnaphthalenesultoπate Cholestcrvl/behenvl/ouvldodecvl laurovl glutamate Diisodecvl adipate
Sorbitan olejte Cholestervl hydroxysteαrαte Dusopropvl αdipαie dimcr dilinoleate
Steareth 10 Cholestervl stearate Dnsopropvl sebacate
Tπcoπtanvl PVP Cholcth 24 Dnsosteαrovl inmeihv lolpropαne silo v silicate
Tπivosteann PEG 6 esters C 18-70 lsopαratlin Diisostearvl adipate
Tπoctvldtxlecvl citrate CI0-I8 CI 2 l8 tπεlyceπdes Dusostearvl dimer dilinoleαte
CI 2- 15 linear alcohols 2 uhvlhexanoate Diisostearvl lumarate D αlαte
Emollient Cocαmidoprop l PG dimomum chloπde Dilinoleic add
ALetvlated alvcol stearate Cocoa (Theobromα cαcαoi butter Dimethicone
Acetvlated hvdrocenαted lanolin Coco-caprylale caprate Dimethicone copolvol
Acetvlated hvdroεeπated lard glvceπde Coco-rαpeseedate Dimethicone copolvol acetate D L almondate
Acetvlated hvdroeenated veπetable glyceπde Coconut (Cocos nucilerαi oil Dimethicone copolvol isυsiearate D lactate
Acetvlated lanolin A I alcohol Cocovl hydrolvzed sov protein Dimethicone Lopolvol methvl ether
Acetvlated lard ^Ivceπde Collagen pfithalate Dimethicone copolvol phthαlαtc
Acetvlated moπoelyceπdes Colloidal oatmeal Dimethicone propvlethv leπediαmine behenate
Acetvlated pjlm kernel glyceπdes Comtrev tSymphvtum ottiunalei leat extract Dimethiconol stearate
Aleuπtes molULcaπa ethvl ester Corn (Zeα mays) oil Dimethv l lauramine oleate
Allantoin Com poppv ( Papaver rhoeαs i extract Diυ tvl αdipαte
Alumiπum/ma-nesium hvdroxide stearate Cottonseed (Gossvplum i oil Dioctvl dimer dilinoleαte
AMP isosiearovl hvdrolvzed sov protein Cuttlefish extract Dioctvlcvclohexane
Apπcot (Prunus αππeniacαi kernel oil Cyclomethicone Dioctvldodecvl dimer dilinoleαte
Arachidvl behenate Deceth -4 phosphate Dioctvldodecvl dodecαnedioαie
Argania spmosa oil Decvl oleate Dioctvl mαlate D sebacate succinate
Avocado I Persea gratissima) oil unsαpoπifiαbles Decvltetradecanol Dipentaervthπtol lαttv acid ester
Avocado oil ethvl ester Diαlkvldimethvlpolvsiloxαne Dipentaeruhπtvl hexαcαprv lαte/hcxαcαprate
Babassu lOrbigπva oleifera) oil Dibutvl sebacate Dipentαerv thπtv I hexahv drox steαrate/isosie rate
Barvl isostearate B stearate Dicαprvl adipate Disteαnldimeihvlamine dilinoleαte
Behenamidopropvl dihvdroxvpropvl dimomum Dicaprvlyl ether D maleate Ditπdecvl adipate chloπde Diethylene glycol dnsonυπanυate Dog rose i Rosα camnαi hips oil Beheπoxv dmethicone Diethvlene glycol diouanoate Egg (O um) volk extract Behenv l alcohol B behenate bis-Diglvcervl/caprv laie/caprate/isostearate/ Emu ( Dromiceiusi il Behenvl erucate B isostearate hvdrox vstearate adi pαte Eπicv I eπicate Benzvl laurate bιs-Dιglvceryl/caprvlate/caprαte/ιsosieareth/ Ethvl α rxadate
Bladderurack iFucus vesiculosusi extract steαrate/hvdroxvsteαrate/αdipαte Ethvlhexvl isopalmitαte Boraεe i Borneo olficiπalisi seed oil Boraiteamidopropv I phosphatidvl PG dimomum chloπde Brain extract
Brazil nut I Bertholettia excelsai oil Butvl mvπstate oleate steoraie Butvloctaπol Butvloctvl oleate C12 13 C i : 16 C I4 l 5 alcohols CI 15 alcohols octanoate C12 15 αlkv l benzoate dl C 12 15 alkvl lumarate CI2 15 alkvl lactate Camellia kissi oil Tea (Camellia sinensisi oil CIO 30 holesterol/lanoster l esters Canola il
Caprv c/capπc tπ-lvceπde Caprv c/capπc tπ-lvceπde PEG-4 esters Caprvli /cαpπc/lauπc tπglyceπde Caprvlic/ αpπc/lmoleic tπglvceπde Caprvlic/capnc/oleic tπelvceπdes Caprv c/capπc/steaπc tπelvceπde Caprvlic/capπc/succini tπglvceπde Capsicum trutescens oleoresin Carrot I Dαucus carota saliva) oil Cashew i Λπacardium occidentalel nut oil Castor I Ricinus communis) oil Cetearvl behenate C caπdehllate Cetearvl isoπoπαnoate C octanoate Cetearvl palmitate C stearate Ceteth- 10
Cetostean 1 stearate Cetvl C 12 15 parcth carboxvlate Cetvl acetate C alcohol Cetvl esters C lactate Cetvl mv nstatc C octanoate Cetvl oleate C pαlmuαte Cetvl PPG 2 isodeceth " ..αrboxv lαte Cetv I ΠL noleαie C -.t-αrαie
Cosmo' c. Bonch .< ιp ->nce ' °°'ι 1 1 " Functions
2-Ethylhexvl isostearate Isononyl isononanoate Octyldodecanol
Ethvl liπolenaie. E minkate Isopentyldiol Octyldodecvl behenate, 0 benzoate
Ethyl moπhuate. E mvnstate Isopropyl avocadate Octyldodecyl erucate, O mynstate
Ethyl oleate. E oiivate Isopropyl C12-15-pareth-9- arboxylate Octyldodecvl oleate, O ncinoleate
Evening pnmrose (Oenodiera bienms) extract, od Isopropyl isostearate Octyldodecyl stearate
Glycereth-45-lactate Isopropyl lanolate, I Imoleate bis-Octyldodecvl stearovl duυcr dibnoleate
Glycereth-5 lactate Isopropyl mvnstate. I. palmitate Octyldodecvl stearoyl stearate
Glycereth-7 benzoate Isopropyl PPG-2-ιsodeceth-7 carboxvlate Oleamtne oxide
Glycereth-7 dnsononanoate Isopropyl stearate Oleic/palmitoieic/linoleic glvcendes
Glycereth-7 tnacetate Isosorbide laurate Oleic alcohol
Glycereth-7 tnoctanoate Isosteanc acid Oleosteanne
Glycereth-12. 26 isostearvl alcohol Olevl alcohol, 0 erucate, O oleate
Glycerol tncaprvlate/caprate Isostearyl behenate. I benzoate Olive (Olea europa) od
Glyceryl adipate. G dioleate Isostearyl diglycervl sucαnate Orange (Citrus aurantium dulcis) peel wax
Glyceryl isostearate G lanolate Isostearvl emcate, I erucvl erucate Orange roughy (Hoplostethus adanticus) od
Glycervl Imoleate G monopvroglutamate Isostearvl isostearate. I lactate Palm (Elaeis gumeensis) oil
Glycervl mvnstate. G oleate Isostearvl maiate. I mynstaie Palm kernel gtyceπdes
Glycervl παnoleate Isostearvl neopentanoate, palmitate Palmitic aαd
Glyceryl tnacetvl hydroxvstearate Isostearvl stearovl stearate Paπthenvl tnacetate
Glyceryl tnacetvl ncinoleate Isostearvlamidopropyl dihydroxypropyl dimonium Partiallv hvdrogenated canola od
Glycosaminoglycans chlonde Partially hvdrogenated soybean oil
Glycosphmgolipids Isotndecvl isononanoate Peach (Prunus persica) extract
Gold of Pleasure oil Isotndecvl mvnstate Peanut (Arachis hvpogaea) oil
Grape (Vϊtis vinifera) seed od Jojoba (Buxus chinensis) oil Pecan (Carva illinoensis) oil
Hazel (Corvlus avellana) nut oil Jojoba butter. J esters PEG-2 dnsononanoate P dioctanoate
Heϋanthus annum ethvl ester Jojoba oil. synthetic PEG-2 πulk solids
Hexadecvl isopalmitate ul cut (Aleuntes molaccana) nut od PEG .
Hexamethvldisiloxane Lactamide DGA PEG-4 diheptanoate P dilaurate
Hexyl laurate Laneth- 10 acetate PEG -5 CS-12 alcohols citrate
Hexyldecanoi Lanolin. L. acid PEG-5 C14-18 alcohols αtrate
Hexvidecvi stearate Lanolin alcohol. L od PEG-5 hvdrogenated castor oil
Honey extract Lanolin, ultra anhvdrous PEG-5 hvdrogenated castor oil tπtsostearate
Hybnd safflower (Carthamus tmctonus) oil Lanolin wax PEG-6
Hybnd sunflower (Hehanϋius annuus) od Lanosterol PEG-6 capπc caprylic glyceπdes
Hydrogenated C6-14 olefin polvmers Lard glvcende PEG-7 glvceryl cocoate
Hydrogenated castor oil Laureth-2. -3 PEG-8
Hvdrogenated castor od laurate Laureth-2 acetate. L benzoate PEG-8 ddaurate, P dioleate
Hydrogenated coconut oil Laureth-2 -octanoate PEG -β/SMDI copolvmer
Hydrogenated cottonseed oil Launc palmitic oieic tnglyceπde PEG-9 stearvl stearate
Hydrogenated C12-18 tnglvcendes Laurvl behenate. L lactate PEG- 10 stearvl stearate
Hydrogenated lanolin Laurvl phosphate PEG-12
Hydrogenated lanolin, distilled Laurv Idimethvlamine isostearate PEG-12 dioleate, P palm kernel glvcendes
Hydrogenated lecithin Lesquerelia fendlen od PEG- 15 cocamine oleate/phosphate
Hydrogenated milk upids Linoleic acid PEG-18
Hvdrogenated mink oil Macadamia ternifolia nut oil PEG-20
Hvdrogenated palm kernel glvcendes Maleated sovbean oil PEG-20 hvdrogenated castor od isostearate
Hydrogenated palm oil Mango (Mag fera indica) oil seed oil PEG-20 hvdrogenated castor oil tπisostearate
Hvdrogenated polvisobutene Mango kernel oil PEG-20 hvdrogenated lanolin
Hydrogenated sovbean od Meadowtoam (Lαmnamhes alba) seed od PEG-24 hvdrogenated lanol
Hydrogenated starch hvdrolvsate Menhaden (Brevooπia tvrannus) oϋ PEG-25 PABA. P propylene glvcol stearate
Hydrogenated tallow glvcende Methvl acetvl ncinoleate PEG-40 glvceryl laurate
Hydrogenated tallow glvcende laαate Methvl gluceth-20 PEG-40 hvdrogenated castor oil isostearate
Hydrogenated turtle od Methyl gluceth-20 benzoate M g distearate PEG-40 hvdrogenated castor odjaurate
Hvdrogenated vegetable glvcendes Methyl hydroxvstearate. M ncinoleate PEG-40 hvdrogenated castor oil tπisostearate
Hydrogenated vegetable od Microcrvstalhne wax PEG-40 jojoba oil
Hydrolvzed collagen Mineral od (Paraf inum liquidum) PEG-50 hvdrogenated castor od laurate
Hydrolvzed conchionn protein MinkoU PEG-50 hvdrogenated castor od tπisostearate
Hydrolvzed keratin Musk rose (Rosa moschata) oil PEG-60 shea butter glyceπdes
Hydrolvzed mushroom (Tncholoma matsutake) Myrelh-3 PEG-70 mango glyceπdes extraα Myrelh-3 caprate, M laurate PEG-75 Hvdrolvzed oat protein MyreUι-3 mvnstate M oαanoate PEG-75 lanolm. P shea butter glvcendes Hydroxvlated lanolin Myπstyl alcohol M lactate PEG-75 shorea butter glyceπdes Hydroxvlated milk glvcendes Myπstyl mvnstate, M octanoate PEG-150 Hvdroxvsteanc acid Myπstyl propionate, M stearate PEG PPG-17/6 copolvmer Elipe butter Neatsfoot od Pentaervthπrvl dioleate
Isobutvl palmitate I stearate Neem (Meha azadirachta) seed od Pentaervthnrvl isostearate/caprate/caprvlate/adipate Isocetvl behenate I octanoate Neopeπtvl glycol dicaprate Pentaerythπtvl stearate Isocetvl palmitate. I salicvlate Neopentvl glvcol dicaprate/dicaprylate Pentaervthπtyl stearate/caprate/caprylate/adipate Isocetvl stearate Neopentvl glycol dnsooctanoate Pentaervthπtvt tetracaprvlate/tetracaprate Isodeceώ-2 cocoate Neopentvl glycol dioctanoate Pentaerythπtvl tetraisononanoate P tetraisostearate Isodecvl αtrate I cocoate Oat (Aveπa sauva) bran extract, extract, flour Pentaervthπtvl tetraiaurate, P tetraoctanoate Isodecvl isononanoate 1 laurate Octacosanvl stearate Pentaervthπtvl tetraoleate. P tetrapelargonate Isodecvl neopentanoate Octyl cocoate Pentaervthπtvi tetrastearate Isodecvl octanoate. I oleate Oαyl hydroxvstearate O isononanoate Perfluorodecal Isodecvl stearate Oαvl neopentanoate 0 octanoate Perfluoropolvmediylisopropyl ether Isododecane Octvi oleate. O palmitate Petrolamm Isoeicosane Octvl pelargonate, O stearate Pheπedivl dimethicone Isohexadecane Octvldecanol Phenvl dimethicone. P methicoπe P tπmethicone
1.20 Cosmetic Bench Reterence 1996 Functions
Phvtantπol PPG-8/SMDI copolvmer Propylene glycol mvπstyl ether acetate
Pistachio I Pistacia vera) nut oil PPG -9 Propylene glycol stearate. SE
Placental enzvmes PPG-9-buteth-12 Pumpkin (Cucurbita pepo) seed oil
Pollen extract PPG-9 butyl ether Quinoa (Chenopodium quinoa) oil
Poloxamer 105 benzoate PPG- 10 butanediol. P. cetvl ether Rapeseed (Brassica campestπs) oil
Poloxamer 182 dibenzoate PPG- 10 methyl glucose ether Rice (Oryza saliva) bran oil. bran wax
Polvbulene PPG- 10 olevl ether Rice fatty aαd
Polvdecene PPG-U stearvl ether Safflower (Carthamus tinctoπus) od
Polvdimethicone copolvol PPG-12-buteth-16 Salmon (Salmo) egg extract
Polvethvlene glycol PPG- 12-PEG-50 lanolm Sesame (Sesamum mdicum) oil
Polvglyceryl-2 diisostearate. P. tetraisostearate PPG-12-PEG-65 lanolin oil Shark liver oil
Polvglyeerv 1-2 tπisostearate PPG-12 SMDI Copolymer Shea butter (Butvrospermum parkn)
Polvglycervl-3 diisostearate. P. oleate PPG-14 butvl ether Shea butter (Butvrospermum parkn) extract
Poivglycervl-3 stearate PPG-15 butyl ether. P. stearvl ether Shea butter, ethoxvlated
Polvglycervl-6 dioleate PPG-15 stearyl ether benzoate Shorea stenoptera butter
Polyglyceryl- 10 decaoleate. P. decastearate PPG-16 butyl ether Silybum maπanum ethyl ester
Polvglycervl- 10 tetraoleate PPG- 18 butvl ether Sitostearvl acetate
Polvisobutene PPG-20 Skin lipids
Polvisobuiene.-isohexapentacomahectane PPG-20-buteth-30 Slippery elm extraα
Polvisobutcπe/isooctahexacontaπe PPG-20 cetvl ether Sodium C8-16 isoalkvlsucαnvl lactoglobulin
Polvisobutene isopentacontaoctane PPG-24-glvcereth-24 sulfonate
Poivisoprene PPG-26 Sodium carboxvmethvl beta-glucan
Polvoxyethvlene polvoxvpropylene glycol PPG-27 glvcervl ether Sodium ceteth-13-carboxvlate
Polvquaιemιum-2 PPG-2S-buteth-35 Sodium dimethicone copolvol acetvl methvltaurate
Polysiloxane polvalkvlene copolymer PPG-30 Sodium glyceryl oleate phosphate
Polvsorbate 40 PPG-30 cetvl ether Sodium hvaluroπate. S. polvmethacrvlate
Potassium dimethicone copolvol phosphate PPG-40 butvl ether Sorbeth-20
PPG-2-buteth-3 PPG-50 cetvl ether. P olevl ether Sorbitan isostearate. S. palmitate
PPG-2 lanolin alcohol ether PPG-51/SMDI Copolymer Sorbitan sesquioleate. S. sesquistearate
PPG-2 myπstyl ether propionate PPG-53 butyl ether Sorbitan moleate
PPG-3 hvdrogenated castor oil Propylene glvcol ceteth-3 acetate Soybean (Glycine soja) oil
PPG-3 mvπstvl ether Propylene glycol dicaprylate Spermaceti
PPG-5-buteth Propylene glycol dicaprvlate dicaprate Sphingolipids
PPG-5-laureth-5 Propylene glycol diisostearate. P.g. dioctanoate Squalene
PPG-5 butvl ether Propylene glycol dipelargonate Stearamidopropyl cetearvl dimo um tosylate
PPG-5 lanolin wax Propylene glycol ιsoceteth-3 acetate Steareth-4 stearate
PPG-5 pentaervthπtvl ether Propylene glycol isostearate. P.g. laurate Steanc acid. S. hydrazide
PPG-7-buteth-10 Propylene glycol mvnstate Stearoxy dimethicone
Cosmetic BPΠCI Reference 19Qf 1.21 Functions
Stearoxymethieoπe/dimeihicoπe copolymer Calcium stearate N-Dodecyl-N.N -dιmethyl-N-( dodecyl acetate)
Stearyl behenate. S. benzoate Calcium stearovl lactylate ammonium chlonde
Stearyl dimethicone. S. erucate Capramide DEA Dodecylpheπol -ethylene oxide condensate
Stearyl heptanoate. S. propionate Capry c/capπc acid Egg (Ovuml yolk extract
Stearvl stearate Caprylic/capπc glyceπdes Emulsifying wax NF
Stearyl stearovl stearate Castor oil. ethoxylated Ethoxylated fatty alcohol
Sucrose cocoate Cetalkomum chloπde N-Ethyledιer-bιs-l.4-(N-ιsosιearylamιdopropyl-
Sunflower iHe anthus annuusi seed oil Ceteareth-2 -4 -5 -6 N.N-dimethvl ammonium chlo
Sweet almond ( Prunus amygdalus dulcisl oil Ceteareth-2 phosphate Ethyl hexanedtol
Sweet cherrv I Prunus avium I pit ml Ceteareth-5 phosphate Euglena gracilis polysacchaπde
Synthetic jojoba oil Ceteareth-8 -IO - I I -12 Glyceredι-26 phosphate
Synthetic wax Ceteareth- 10 phosphate Glyceryl caprylate. G caprylate/caprate
Tallow Ceteareth-15 -17 -20 -25 Glyceryl citrate/lactaie/linoleate/oleate
Tetradecycleicosvl stearate Ceteareth-27 -29 -30 -34 Glyceryl cocoate. G. dilaurate
Tocopheryl acetate Cetearyl alcohol Glyceryl dilaurate. G. dioleate
Tncapnn Cetearyl glucoside Glyceryl distearate. G. hydroxysicaraie
Tπcapryhπ Ceteth-2 -4 -6 -10 -12 -13 Glyceryl isostearate. G. lanolate
Tπcaprylyl citrate Ceteth-16 -20 -25 -30 -33 Glyceryl laurate. G. Imoleate
Tπcholoma matsutake extract Cetethyldimomum bromide Glyceryl mono-di-tπ-caprylate
Tπdecyl behenate. T. cocoate Cetπmυnium chloπde Glyceryl myπstate. G. oleate
Tπdecyl erucate. T. neopeπiaπoule Cetyl dimethicone copolvol Glyceryl palmitate. G. ncinoleate
Tπdecvl octanoate. T stearate Cetyl phosphate Glyceryl ncinoleate SE
Tπdecvl stearovl stearate Cholesterol Glyceryl stearate. G. stearate citrate
Tπdecvl tπmellitate Cholcth-I0 -I5 -24 Glyceryl stearate lactate
Tπhexvldecvl citrate Cocamide DEA. C MEA Glyceryl stearate SE
Tπisocetvl citrate Cocamidopropyl dimethvlamine Glyceryl undecvlenate
Tπisosteaπn Cocamidopropvl PG-dimo um chloπde Glycol distearate. G. oleate
Tπisostearyl citrate phosphate Glycol palmitate. G stearate
Tπisostearvl tnhnoleate Cocamine Glycol stearate SE
Tnlaunn Coceth-7 carboxylic acid Glycolamide stearate
Tπlinolein Coconut acid Glycosphingolipids
Tπmethylolpropane tπcaprvlatc/lriLaprate Copper protein complex Hydrogenated coco-ghceπdes
Tπ ethy lolpropane tπcocoate Cottonseed glvcende Hydrogenated cottonseed glvcende
Tπmethylolpropane tπlaurate CI2-13 pareih-3 -4 -9 -23 Hydrogenated lanolin
Tπmyπstin CI6-18 pareth-3 -5.5 -13 -19 Hydrogenated lecithin
Tπoctanoin Cyclodextπn Hydrogenated palm oil
Tπoctyldodecvl curate Decaglycerol monodioleate Hydrogenated soy glvcende
Tπolein DEA-ceteareth-2-phosphate Hydrogenated tallow glycerides
Tπpalmmn DEA -cetyl phosphate Hydrogenated tallow glyceπdes citrate
Tπpropylene glycol citrate DEA-cyclocarboxypropyloleate Hydroxycetyl phosphate
Tπsteaππ DEA-oleth-3 phosphate Hydroxvlated lanolin
Tπundecanoin DEA-oleth-5-phosphate Hydroxvlated lecithin
Vegetable oil DEA oleιh-10 phosphate Hydroxyoctacosanyl hydroxvstearate
Walnut (Juglans regiai oil DEA-oleth-20-phosphate Hydroxypropyl-bis-
Wheat iTπticum vulgare) germ oil Diceteareth- 10 phosphoπc acid lsostearvamidopropyldimonium chloπde Diethanolamine lsoceteareth-8 stearate
Emulsifier Diethvlaminoethvl stearate Isocetedι-10 stearate
Acetvlated hvdrogenated lard glvcende Diglyceryl stearate malate lsocetedι-20
Acetylated hvdrogenated vegetable glvcende Dιhvdrocholeth-15 -20 -30 Isocetvl alcohol
Acetvlated monoglyceπdes Dihydrogeπated tallow phthalic acid amide lsolaureth-6
Acrylates/C10-C30 alkvl jcrylate crosspolymer Dilauryl acetvl dimomum chlonde Isostearamidopropyl dimethvlamine gluco late
Acrylates/vinyl isodecanoate crossrxilymer Dilinoleamidopropyl dimethvlamine dimethicone Isostearamidopropyl dimethvlamine glvcolate
Acrylic acid acrylonitrogens copolvmer copolvol phosphate Isostearamidopropyl laurvlacetodimonium
2-Amιnobutanol Dilinoleic acid chlonde
Ammonium acrvlates/acrylomtrogens copolymer Dimethicone copolvol almondate Isosteareth-2 -3 - 10 - 12 -20 _2 -50
Arachidyl alcohol Dimethicone copolvol isostearate Isostearedι-2-octanoate
Beeswax Dimethicone copolvol laurate Isosteareth- 10 stearate
Behenamidopropvl dihvdroxypropvl dimomum Dimethicone copolvol methvl ether Isosteaπc acid chloπde Dimethicone copolvol olivate Isostearyl diglyceryl succinate Beheneth-5 - 10 -20 -30 Dimethicone copolvol phthalate Isostearylamidopropyl dihvdroxypropvl dimomum Behe c acid Dipalmitoylethyl hydroxyethylmomum chlonde Behenvl betaine methosulfate Karava (Steπculia ureπsi gum Borageamidopropyl phosphatidvl PG-dimonium Dipropylene glycol Laneih-5 -10 -15 -16 -20 .0 chloπde Disodium hydrogenated cottonseed glvcende Lanedi- 10 acetate Butvloctanol sulfosuccmate Lanolin C 12-20 acid PEG-8 ester Disodium πcmoleamido MEA-sulfosuccinate Lanolin alcohol Cl8-36 cιd Disodium stearyl sulfosuccmate Lanolin, ultra anhydrous
Calcium dodecylbenzene sulfonate Disodium sulfosuccinamide Lanolin wax Calcium protein complex Distearyl phthalic acid amide Lauπunide DEA. L. MEA
1.22 Cosmetic Bench Reference 1 996 Functions
Lauramidopropyl dimethvlamine PEG-5 lanolate. P. oleamine PEG-20 lanolin, P. laurate
Lauramidopropvl PG-dimonium chloπde PEG-5 soy sterol, P. sovamine PEG-20 oleate
Laureth-1 -2 -3 -4 -5 PEG-5 stearamme. P. stearate PEG-20 methyl glucose sesquistearate
Laureth-2-octanoate PEG-5 tallow amine PEG -20 sorbitan beeswax
Laureth-3 phosphate PEG-6 capπc caprylic glyceπdes PEG-20 sorbitan isostearate
Laureth-4 carboxvlic acid PEG-6 cocamide PEG-20 sorbitan tπisosterate
Laureth-5 carboxvlic acid PEG-6 C12-14 ether PEG-20 sorbitan tπoleate
Laureth-6 -7 -9 -11 -12 PEG-6 dilaurate. P. dioleate PEG-20 stearate. P. tallow amine
Laureth- 11 carboxvlic acid PEG-6 distearate, P. isostearate PEG-23 oleate, P. stearate
Laurelh- 16 -20 -23 -25 -30 PEG-6 lauramide. P. laurate PEG-24 hydrogenated lanolin
Lauryl PCA PEG-6 oleate, P. palmitate PEG-25 castor oil
Laurylmethicone copolyol PEG -6 sorbitan beeswax PEG-25 phytosterol
Lecithin PEG-6 sorbitan laurate PEG-25 propylene glycol stearate
L oieamidopropyi PG-dimonium chloπde PEG-6 sorbitan oleate PEG-25 soy sterol, P. stearate phosphate PEG-6 sorbitan stearate PEG-29 castor oil Lithium stearate PEG-6 stearate PEG 0 castor oil
Magnesium sulfate hepta-hydrate PEG-6-32 PEG-30 dipolyhydroxystearate Maleated sovbean oil PEG-6-32 stearate PEG-30 glyceryl cocoate
Methoxv PEG-17/dodecyl glycol copolymer PEG -7 glyceryl cocoate PEG-30 glyceryl isostearate Methyl gluceth-20 distearate PEG-7 hydrogenated castor oil PEG- 0 glyceryl laurate Methyl glucose dioleate, M. g. sesquiisostearate PEG-7 oleate PEG-30 glyceryl oleate Methyl glucose sesquistearate PEG-7.5 tallowamine PEG-30 glyceryl stearate MEA-laureth sulfate PEG-8 PEG-30 hydrogenated castor oil Myreth-3 -4 -7 PEG-8 beeswax. P. castor oil PEG-30 lanolin Myreth-3 mvnstate PEG-8 C12-14 ether PEG-30 sorbitan tetraoleate Myπstamidopropyl dimethvlamine PEG-8 dilaurate. P. dioleate PEG-32 dilaurate. P. dioleate Nonoxvnol- 1 -2 -4 -5 -6 -7 PEG-8 distearate PEG-32 distearate. P. laurate Nonoxvπol-8 -9 -10 -11 -12 -13 PEG-8 glyceryl laurate PEG-32 oleate. P. stearate Nonoxynol- 14 - 15 -18 -20 -30 -40 -50 PEG-8 laurate. P. oleate PEG-33 castor oil Nonyi nonoxynol-5 -10 PEG-8. P. tallate PEG-35 castor oil. P. stearate Oat (Avena sativa) flour PEG-9 castor oil PEG -40 castor oil θctoxynol-1 -3 -5 -8 -10 PEG-9 diisostearate PEG-40 glyceryl isostearate Octoxynol 16. 30. 40 PEG-9 dioleate. P. distearate PEG -40 glyceryl laurate 2-θctyl dodecvl alcohol PEG-9 laurate, P. oleate PEG-40 glyceryl tπisosiearate Octyldodecanol PEG -9 stearate PEG -40 hydrogenated castor oil θctyldodeceth-20 -25 PEG-10 castor oil. P. cocamine PEG-40 hydrogenated castor oil PCA isostearate Olea ide DEA PEG-10 coconut oil esters PEG-40 sorbitan diisostearate
Olea idopropvl dimethvlamine PEG-10 C12-18 alcohols PEG-40 sorbitan lanolate Olea ine oxide PEG- 10 dioleate PEG -40 sorbitan tetraoleate Oleic acid PEG-10 glyceryl isostearate PEG-40 stearate θleth-2 -3 -4 -5 -6 -7 -8 -9 PEG-10 hydrogenated castor oil PEG-40/dodecyi glycol copolymer Oleth- 10 - 12 - 15 -20 -23 PEG- 10 hvdrogenated castor oil tπisosiearate PEG-42 babassu glyceπdes Oleth-25 -30 -40 -50 PEG- 10 lanolate PEG-44 sorbitan laurate Oleth 13 PEG-10 polvglycerv 1-2 laurate PEG-45 palm kernel glyceπdes θleth-2 phosphate PEG- 10 sorbitan laurate PEG-45 safflower glyceπdes
Oleth-3 phosphate PEG- 10 sov sterol. P. stearamine PEG-50 lanolm. P. stearamine θleth-5 phosphate PEG- 10 stearate PEG-50 stearate
Oleth- 10 phosphate PEG- 11 babassu glvcendes PEG-60 almond glvcendes θleth-20 phosphate PEG- 11 castor oil PEG-60 castor oil
Palm acid PEG- 12 dilaurate. P. dioleate PEG-60 corn glyceπdes
Palmitamidopropvl dimethvlamine PEG-12 distearate PEG-60 glyceryl tπisostearate
Palmitic acid PEG-12 glyceryl dioleate PEG-60 hvdrogenated castor oil
PEG-2 cocamine. P. distearate PEG-12 laurate, P. oleate PEG-60 hydrogenated castor oil isostearate
PEG-2 hvdrogenated tallow amine PEG-12 stearate. P. tallate PEG-60 hydrogenated castor oil tnisostearate
PEG-2 laurate. P laurate SE PEG-14 avocado glvcendes PEG-60 shea butter glvcendes
PEG-2 oleamine. P. oleate PEG- 15 castor oil PEG -60 sorbitan tetraoleate
PEG-2 sovamine. P. stearamine PEG- 15 cocamine PEG-70 mango glyceπdes
PEG-2 stearate. P. stearate SE PEG- 15 glyceryl isostearate PEG-75
PEG-3 cocamide PEG- 15 glyceryl laurate PEG-75 castor oil. P. dilaurate
PEG-3 C12-C18 alcohols PEG-15 glyceryl ncinoleate PEG-75 dioleate. P. distearate
PEG-3 glycervl isostearate PEG- 15 oleamine. P. oleate PEG-75 lanolin. P. laurate
PEG-3 glycervl tπisostearate PEG- 15, P. stearamine PEG-75 oleate
PEG-3 glvceryl tπstearate PEG- 15 tallow amine PEG-75 shea butter glyceπdes
PEG-3 lanolate. P. sorbitan oleate PEG- 15 tallow polvamiπe PEG-75 shorea butter glycendes
PEG-3 stearate PEG-16 PEG-75 stearate
PEG -4 dioleate. P. diisostearate PEG- 16 hydrogenated castor oil PEG-80 sorbitan laurate
PEG-4 dilaurate. P. distearate PEG-16 soy sterol PEG-90 stearate
PEG -4 glyceryl distearate PEG-18 stearate PEG-100 castor oil
PEG-4 laurate, P. oleate PEG-20 almond glyceπdes PEG-100 hydrogenated castor oil
PEG-4 stearate PEG-20 castor oil. P. dilaurate PEG- 100 lanolin. P. stearate
PEG-4 stearyl stearate PEG-20 dioleate, P. distearate PEG-120 distearate
PEG-4 tallate PEG-20 glyceryl laurate PEG-150 dilaurate. P. dioleate
PEG-5 castor oil. P. cocamine PEG-20 glyceryl oleate PEG- 150 distearate. P. lanolin
PEG-5 C12-C18 alcohols PEG-20 glyceryl stearate PEG-150 laurate. P. oleate
PEG-5 glvcervl isostearate PEG-20 glyceryl tπisostearate PEG-150 stearate
PEG-5 glvcer l sesquioleate PEG-20 glycervl tπstearate PEG-200 castor oil
PEG-5 glvcervl stearate PEG-20 hvdrogenated castor oil PEG-200 glvcervl stearate
PEG-; stlvcer l triisoslcarate PEG-20 hvdrogenated lanolin PEG-200 hvdrogenated castor oil
1.24 Cosmetic Bench Reference I QQ6 Functions
PEG-200 laurate. . "leate Sodium C12-15 pareth-15 sulfonate Tallowamidopropyl dimethvlamine
PEG-400 laurate Sodium isostearoyi lactylatc Talloweth-6
Phosphate esters Sodium iaureth-17 carboxylate Tetrasodium dicarboxyethyl stearyl
Phosphated amine '/xides Sodium lauroyl lactylate sulfosuccmamide
Phospho pids Sodium lauryl sulfate TEA-acrylates/acrvlonitrogens copolymer
Poloxamer 101. ) <ή. 122. 123,124 Sodium nonoxynol-ό phosphate Tissue extract
Poloxamer 181, 1 *2. 184.185, 235, 237 Sodium octyl sulfate Tπceteareth-4 phosphate
Poloxamer 238. 33-*. 338,407 Sodium oleate Trideceth-3. -5, -6. -7, -8
Polyglycervl-2 oleate Sodium oleyl sulfate Trideceth-9, -10, -12. -15
Polyglyceryl-2 polyhydroxvstearate Sodium phosphate Tridecyl ethoxylate
Polygiycervl-2 se . (uiisostearate Sodium stearovl lactylate Tnethanolamtne
Polyglyceryl-2 stearate Sorbeth-20 Tnlaureth-4 phosphate
Polyglyceryl-2-PF_ ;-4-dιstearate Sorbitan isostearate, S. laurate Triolein
Polyglyceryl-2-PL''<-4 stearate Sorbitan oleate. S. palmitate Tπsodium HEDTA
Polyglyceryl-3 diivtstcarate. P. dioleate Sorbitan sesquiisostearate Tristeaπn
Polyglyceryl-3 distearate Sorbitan sesquioleate. S. sesquistearate
Polyglyceryl-3 mcthylglucose distearate Sorbitan stearate. S. tπisostearate
Polyglyceryl-3 olc.ilc. P. polyπcinoleate Enryme
Sorbitan tπoleate, S. tπstearate Fermented vegetable
Polyglyceryl-3 stcaiale Sovamidopropyl dimethvlamine Ganoderma lucidum oil
Polyglyceryl-4 olc.ilc, P. stearate Sovamine Upase
Polyglycervl-6 dmlcjlc. P. distearate Stearamide DEA Papain
Polyglycervl-6 laur.itc. P. mvnstate
Slearamide DIBA-stearate Soy (Glycine soja) protein
Polyglycervl-6 olc.ilc, P polvπcmoleate
Stearamidoethvl diethvlamine Superoxide dismutase
Polyglycervl-6 stcar.ue
Stearamidopropyl dimethvlamine lactate
Polyglyceryl-8 olc.ilc
Polyglycervl-10 dcc.ioleate Stearamidopropyl PG-dimonium chloπde Essential oil phosphate Aesculus chinensis extract
Polyglyceryl- 10 diisiistearaie
Polyglyceryl- 10 dioleate. P. dipalmttate Stearamine Artemisia apiacea extract
Polyglyceryl- 10 disicarate. P. isostearate Stearamine oxide Brassica rapa-depressa extract
Polyglycervl-10 laur te. P. linoleate Steareth-2. -4, -6. -7, -10, -11, -13 Caraway (Carom ca ) oil taπa cardamomum) oil
Polyglyceryl- 10 mixed fatty acids Steareth-2 phosphate Cardamon (Elet
Polyglyceryl- 10 mvr'siaie Steareth-15. -20. -21, -30. -100 Clove (Eugenia caryophyllus) oil
Polyglyceryl- 10 olc.ite Steanc actd Eclipta alba extract
Polyglycervl-10 pcπl.islcarate Sucrose cocoate. S. distearate Eucalyptus globuius oil
Polyglyceryl-10 slc.ir.itc Sucrose stearate Euphotoπum fortune! extract
Polyglycervl- 10 telr.mleate Synthetic beeswax Euterpe precatoπa extract
Polyglyceryl- 10 iπnlc.iie Tallow glvcende. acetvlated hydrogenated Hierochloe odorata extract extract
Polvoxyethylene polvoxvpropylene glycol Tallowamide DEA Kadsura heteliloca
Polvquatemιum-5. - ' I
Polysorbate 20. 21. 10. 60. 61
Polysorbate 65. 80. H I . 85
Potassium alginaic. I" cetvl phosphate
Potassium laurate. I' mvnstate
Potassium tallowate
PPG-l -PEG-9 laurvl ulycol ether
PPG-2-ceieareth-'>
PPG-3 isosteareth-1'
PPG-3 PEG-6 olev llιer
PPG-5-buteth-7
PPG-5-ceteth-20
PPG-5-ceteth- 10 phosphate
PPG-8 oleate
PPG- 10 cetvl ether phosphate
PPG- I 2-PEG-50 lanolin
PPG- 15 stearvl ether
PPG-24-buteth-27
PPG-25 laureth-25
PPG-26-buιeth-26 l'PG-26 oleate
PPG-36 oleate
Propylene glvcol jlmn ie. P.g. dioleate
I'ropvlene glycol hvdroxvstearate
Propylene glvcol l.iui.iie. P.g. ncinoleate
Propylene glvcol πuπoleate SE
Propylene glycol stearate
Propylene glycol stc.ir.ite. SE
Ouaternιum-33
K.ipeseedamidopropv I ethvldimomum ethosulfate
Kicc (Orv a sativa) bran wax
Kicinoleamidc DEΛ
Kicinoleic acid
S.ipomns
Selenium proiein complex
Silicone qu.iivrnium- . -6 o ium crv I.HCSΛ im I isodecanoate crosspolymer
Sodium oipmvl laci late
Sodium t.irhi nner
Sodium wiv l siilfju
' ' rnι 'ii I '.i in ■ \ rerence 19 6 1.25 Functions
Ligustnim lucidum extract PVM/MA decadiene crosspolymer Lauramidopropyl betaine Lysimachia foenum-graecum extract PVP/Dimethiconvlacrvlate/polvcarbamvl/ Lauryl betaine Melaleuca bracteata extract poiyglycol ester Myπstamidopropyl dimethvlamine dimethicone Melaleuca hvpercifolia extract PVP/dimethvlaminoeihylmethacrvlate copolymer copolyol phosphate Melaleuca symphvocarp extract PVP/dimethvlamtnoethylmethacrylate/ Myπstamine oxide Melaleuca uncinata extract polvcarbamvl/polyglycol ester Octyldodecvl benzoate Melaleuca wilsonit extract PVP/eicosene copolvmer Oleamide DEA, O MIPA Nasturtium sinensis extract PVP hexadecene copolymer Oleyl betaine Nelumbium speciosum extract PVP hydrolvzed wheat protein copolymer Palm kemelamide DEA Paulowma impeπalis extract Rice peptide PEG-3 lauramine oxide Rosemarv (Rosmarinus officinalis) oil Seπcin PPG-15 stearvl ether benzoate Selinum spp extract Shea butter (Butvrospermum parkii) PEG -7000 Tπchomonas japomca extract Shellac Sodium cocoamphoacetate Witha a sommferum extract Sodium C12 15 pareth-7 sulfonate Sodium coco v I isethtonate Yuzu oil Sodium hvaiuronate Sodium laureth sulfate Ziziphus jujuba extract Soluble collagen Sodium laurovl wheat ammo acids Soluble keratin Sodium octoxynot-2 ethane sulfonate
Exfoliant Soluble wheat protein Sovamidopropyl betaine
Apncol ( Prunus armemaca) kernel powder TEA-acrylates/acrvlonitrogens copolymer Tallowamide MEA
Glycolic acid Tosvlamide/epoxv resin
Jojoba (Buxus chinensis) seed powder Tπcontanvl PVP Foam stabilizer
Lactic acid Tnetho um hvdrolvzed collagen ethosulfate Babassuamidopropv lamine oxide
Papain Wheat peptide Behenamme oxide
PEG 11 -Avocado Glvcerdies Caprvlvl pvπolidone
Willow (Salix alba) bark extract Fixative Cetamine oxide
Acrylates copolvmer Cocamide DEA C MEA. C MIPA
Fiber Adiptc acid/dtmethvlaminohvdroxypropvl Cocamidopropvl betaine
Corn (Zea mavs) cob powder diethvlene tπamine copolvmer Cocamidopropyl hvdroxvsultame
Nvlon-66 A P-acrvlates copolvmer Cocamidopropvl laurvl ether
Oat (Avena sativa) bran, meal Hydrolvzed zein Cocamidopropvlamine oxide
Ravon Methacrvlol ethvl betaine/acrvlates copolvmer Cocamine oxide Methvl rosinate Dihvdroxyethvl C12 15 alkoxvpropylamine oxide
Film former Polvquatemιum-4 -10, -29 Dihvdroxvethvl cocamine oxide
Acetvlated lanolin PPG-20 methvl glucose ether Dihvdroxvethvl tallowamine oxide
Acrvlates/hvdroxvesters acrvlates copolvmer Sodium polvstvrene sulfonate Erucamidopropvl hvdroxvsultame
Acrylates/octvlarvlamide copolvmer Hvdroxvpropyl methvlcellulose
Acrvlates copolvmer Flavor (aroma) Isostearamide DEA
Alkvlated polvvinvlpvrrolidone Benzaldehvde Lauramide DEA, L MEA
Ammonium acrvlates/acrvlonitrogens copolvmer Carawav (Carum ca ) oil Lauramidopropvlamine oxide
Betaglucan Cardamon (Elettana cardamomum) oil Lauramine oxide
Bladderwrack (Fucus vesiculosus) extract Cinnamon (Cinnamomum casia) oil Laureth- 10
Carboxvmelhvlchitosan Clove (Eugenia carvophvllus) oil Launc-linoleic DEA
N θ-Carboxvmethvlchιtosonιum Ethvl vanillin Lauroyl-linoleovl diethanolamide
Chitosan lactate Eucalvptus globuius oil Laurovl-mvπstovl diethanolamide
Collagen Flavor (aroma) Laurvl pvπolidone
Collagen phthalate Glutamic acid Lmoleamide MEA
Colloidal oatmeal Glvcvrrhetinic acid Mvnstamide DEA. M MEA
Desamido collagen Glycyrrhizic acid Oleamide MEA
Dusostearovl mmethvlolpropane siloxv silicate Glvcvrrhiziπ. ammomated Palmitamide MEA
DMHF Methyl salicylate PEG-3 lauramide
Ethvl ester of hvdrolvzed silk Orange (Citrus aurantium dulcis) oil PEG-4 oleamide
EΛylcellulose Peppermint (Mentha pipenta) oil Ricinoleamide MEA
Geilan gum Rosemarv (Rosmannus officinalis) oil Sesamide DEA germamide DEA
Glvceπn/diethvlene glvcol/adipate crosspolymer Sodium glycyrrhiz ate Wheat
High beta-glucan barlev flour Thymol
Hvdrolvzed collagen Vandlin _aaπ__
Ammonium laureth sulfate
Hvdrolvzed keratin
Hydrolvzed oat protein Foam booster Ammonium laureth-5 sulfate
Hvdrolvzed pea protein Alkyldimethv lamine oxide Ammonium laureth- 12 sulfate
Hydrolvzed reticulin Babassuamidopropvl betaine Ammonium lauryl sulfate, A 1 sulfosuccmate
Hvdrolvzed RNA Babassuamidopropv lamine oxide Ammonium mvreth sulfate
Hvdrolvzed silk Caprylyl pyπolidone Ammonium nonoxynol 4 sulfate
Hydrolvzed sov protein Carrageenan (Chondrus cnspus) Caprvl caprvlylglucostde
Hvdrolvzed wheat protein Cocamide DEA. C MIPA Cetvl betaine
Hydrolyzed wheat protetndimediicone copolyol Cocamidopropvl betaine Cocamide dimethvlamine phosphate copolvmer Cocamidopropvl dimethvlamine lactate Cocamidopropyl Hydrolyzed wheat protem/PVP copolymer Cocamidopropvl hydroxvsultaine Cocamidopropyl dimethvlamine iactate Hvdroxvpropvlcellulose Coco-betaine DEA-laureth sulfate Hydroxypropvltπmonium gelatin Coco/oleamidopropyl betaine DEA laurvl sulfate Jojoba (Buxus chinensis) oil Cocoyl amido hydroxy sulfo betaine Decvl glucoside acetate Lactoglobolin Cocoyl monoethanolamide ethoxylate Disodium caproamphodi
Mvπstovl hvdrolvzed collagen DEA-hvdrolvzed lecithin Disodium caproamphodipropionate Nitrocellulose Dimethvl lauramine Disodium capryloamphodiacetate
Oat (Avena sauva) extract protein Disodium cocamido MEA-sulfosuccinate Disodium cocoamphodipropionate Polvelhvlene nomer Disodium cocoamphodiacetate Disodium lauroamphodiacetate Polvqujternium 6 7 11 22 9 Disodium lauramido MEA-sultosuccinate Disodium lauroamphodipropionate Polvvinv I acetate P alcohol Disodium laureth sulfosuccmate Disodium laurvl sulfosuccmate P'o olla^cn Lauramide MIP . Disodium υleamido MEA sultosuccinaie Functions
Disodium oleamido MIPA-sulfosuccmate Aluminum distearate. A. tπstearate Cetearyl tπmomum methosulphate
Disodium PEG-4 cocoamido MIPA-suifosuccinate Ammonium acrylates/acrylonitrogens copolymer Cetπmoπium bromide. C. chloπde isostearamidopropylamiπe oxide Behenic acid Cetyl pyndimum chlonde
Lauryl glucoside Calcium alginate Chia (Salvia hispanica) oil
Methvl gluceth-20 Carbomer Chrysanthemum moπfolium extract
MEA-laureth sulfate Carboxymethylchitosan Cinchona succiπibra extract
Mixed isopropaπolamines mvnstate Cocamidopropyl dimethvlamine propionate
MIPA-laurvl sulfate N.O-Carboxymethvlchuosonium
Carrageenan (Chondrus cπspus) Coc nea indica extract
PEG-80 sorbitan laurate
PEG laurvl ether sultate Ceresin Cocodimomum hydroxypropyl hydrolyzed
Potassium cocoate. P. lauryl sulfate Cetearyl candelillate collagen
Quillaja saponana extract Dibeπzylideπe sorbitol Cocodimomum hydroxypropyl hydrolyzed keratin
Sodium caproamphoacetate Ethylene/acrylic acid copolymer Cocodimomum hydroxypropyl silk am o acids
Sodium capryloamphoacetate Ethylene/VA copolymer Cocodimomum hydroxypropyl hydrolyzed wheat
Sodium capryloamphohvdroxypropylsulfoπate Gellan gum protein
Sodium cocoamphoacetate Hexanediol behenyl beeswax Cocodimomum hvdroxypropyloxyethyl cellulose
Sodium cocoamphopropionale Hydrogenated jojoba oil Cocotnmonium chlonde
Sodium C12-15 pareth-25 sulfate Hydrogenated jojoba wax Collagen amino acids
Sodium CI2-15 pareth-3 sulfonate Hydroxvsteaπc acid Cyclomethicone
Sodium C12-15 pareth-15 sulfonate Jojoba wax L-cysteine HCL
Sodium C14-16 olefin sulfonate Laneth-5. -15 Dibeheπyldimonium methosulfate
Sodium deceth sulfate Montmonllomte Dicet ldimomum chloride
Sodium laureth-2 sulfate Myreth-3-octanoate Dicocodimoπium chlonde
Sodium laureth-3 sulfate Octacosanvl stearate Dihvdroxvethvl tallowamine oleate
Sodium laureth-7 sulfate θleth-3 phosphate Dimedncone
Sodium lauπminodipropionate Oleth- 10 phosphate Dimethicone copolyol acetate. D. c. almondate
Sodium laurylether sulfosuccmate Poloxamer 105, 123, 124. 185.235 Dimethicone copolyol amine
Sodium laurvl sulfate. S. 1. sulfoacetate Poloxamer 237, 238, 38.407 Dimethicone copolyol bishydroxyethvlamine
Sodium laurvl sulfosuccmate Polyethylene Dimethicone copolyol isostearate. D. c. laurate
Sodium magnesium laureth sulfate Dimedncone copolyol olivate
Polyethylene, oxidized
Sodium myreth sulfate. S. myπstyl sulfate Dimethicone hydroxypropyl tπmonium chloπde
Sodium tndeceth sulfate Polyquaιernιum- 1 Dimethyl lauramine dimer diiinoleate
Sodium tπdecvl sulfate Potassium alginate. P. chlonde Dioleylamidoethyl hydroxyethylmontum
TEA-dodecylbenzenesulfonate Sodium nonoxynol-6 phosphate methosulfate
TEA-laureth sulfate Sodium tallowate Dipalmitovlethvl hvdroxvethvlmonium
TEA -laurovl collagen ammo acids Synthetic beeswax methosulfate
TEA-laurovl keratin ammo acids TEA-acrylates/acryloπitrogeπs copolymer Diphenyl dimethicone
TEA -laurvl sulfate Tribehenin Ditallowdimomum chloπde
TEA-palm kernel sarcosinate N-Dodecyl-N.N-dimethyl-i .-(dodecyl acetate )
Wheat germamidopropyl betaine Glosser ammonium chloride 18-36 acid glvcol ester Eπtada phaseoloides extract
Yucca vera extract C Ethyl ester of hydrolyzed animal protein
Diphenyl dimethicone Gelatin
Fra rance Methyl gluceth-10 Ginseng hydroxypropyltπmonium chloπde
Cha aecvpans obtusa oil Octyldodecvl lactate butvlene glycol Orange (Citrus aurantium duicis) oil Phenyl methicone. P tπmethicone Hematin Peppermint (Meniha pipeπta) oil Polyglyceryl-2 dioleate Hoπev (Mel) Pheπethyl alcohol Polvisobutene Hydrolvzed collagen
Polyisobuleπe/isohexapeπtacontahectane Hydrolvzed hair keratin
Fragrance solvent Polyisobuieπe/isooctahexacoπtane Hydrolvzed vegetable protein
Benzyl benzoate Hydrolyzed wheat proteiπ dimethicone copolyol
Polvmethacrvlamidoprop ltπmonium chloπde acetvl copolvmer Diethvl phthalate PPG- 10 methyl glucose ether Hydrolvzed wheat protein hvdroxypropyl Triacetin PPG-36 oleate polvsiloxane Tπethyl citrate Tea (Camellia sinensis) oil Hydroxvethyl cetvldimonium phosphate
Tribehenin Hydroxvpropyltπmonium hvdrolvzed collagen
Fupgjςjde Hydroxypropyl tπmonium hvdrolyzed wheat
Astrocarvum murumuru extract Hair care protein polvsiloxane copolymer
Azadirachta indica extract Genttana scabra extract Hyssop (Hyssopus officinalis) extract
Captan Maidenhair fern extract Inga edulis extract
Diiodomethvltolvlsuifoπe Nicotinamide Isostearamidopropylamine oxide
Ficus racemosa extract Nicotinic acid Isostearoyl hydrolyzed collagen
Hexettdine Paeonia lactiflorum extract Keratin amino acids
Ligusticum jeholeπse extract Watercress (Nastuπium officinale) extract Kiwi (Actimdia chinensis) fruit extract
Mauntia flexosa extract Kola (Cola acumiπata) extract
Melaleuca svmphvocarp extract Hair conditioner Laminaπa japomca extract
Melia australasica extract Amino bisprop l dimethicone Laurtnmo um chlonde
Melia azadirachta extract Amodimethicoπe Lauryl hydroxypropyl tπmonium polvsiloxane
Mushroom (Cordvceps sabolifera) extract A PD-isostearoyl hydrolyzed collagen copolymer
Mushroom (Coπoius versicolor) extract Aqua Ichthammol Lauryldimethvlamiπe isostearate
Sodium undecvlenate Babassu (Orbignya oleifera) oil Lauryldimonium hydroxypropyl hydrolyzed
Tea tree (Melaleuca alternifolia) oil Babassuamidopropalkonium chloπde collagen
Thiabendazole Behenamidopropvl dimethvlamine Lauryldimonium hydroxypropyl hydrolyzed wheat
Undecvlenamide MEA Behenamidopropyl hydroxyethyl dimomum protein
Zinc undecvlenate chloπde Linoleamidopropyl dimethvlamine dimer
Ziziphus jujuba extract Behentπmonmm chloride diiinoleate Biotin
Gellant Linoieamidopropyldimethylamine
Bishvdroxvethvl biscetvl malonamide Lysimachia toenum-graecum extract
Acrvlic acid/acrvloπitrogens copolvmer Borageamidopropyl phosphatidvl PG-dimoπiurn Melaleuca hypercifolia extract
Agar chloπde Ocimum santum extract
Algin Brazil nut (Bertholettia excelsa) oil Olealko um chloπde
Cosmetic Bench Reference 1996 1.27 Functions
Oleyl dimethvlamidopropyl ethomum ethosulfate VA/butyl maleate/isobotnyl acrylate copolymer Panthenvl ethyl ether
Palraitamidodecanediol VA/crotonates/vinyl neodecanoate copolymer PCA
Panthenvl ethvl ether VA/crotonates/vinvl propionatc copolvmer PEG^t
Pautownia imperiahs extract VA/crotonates copolymer Polyammo sugar condensate
Peach (Prunus persica) leat extract Vinyl caprolactam/PVP/ Potassium lactate
PEG-2 cocomomum chloride dimethytaminoethv Imethacrvlate copolvmer Propylene glycol
PEG- 120 jojoba acid/alcohoi Propyltπmo um hydrolvzed collagen
PG-hvdroxycellulose lauryldimonium chlonde Hair sheen Propyltπmomutn hydrolvzed sov protein
PG-hvdroxveihvlcellulose cocodimomum chlonde Maidenhair fern extract Propyltnmonium hydrolvzed wheat protein
PG-hvdroxvethvlccllulose laurvldimomum Tetrabutoxvpropyl methicone Qualemιum-22 chlonde Rice (Oryza sattva) germ oil PG-hydroxvethvlcellulose stearyldimomum Hair waving Sea Salts (Mans sal) chloride Ammonium thioglycolate. A thiolactate Shea butter (Butyrospermum parkn) Phenyl tπmethicone Argania spinosa oil Silk powder Phospholipids L-cysteine HCL Sodium behenovl lactylate Phytantπol Cystine Sodium caproyl lactviate
Polyoxvethvlene polvoxypropylene glycol Diammomum dithtodiglvcolate Sodium cocoyl lactviate Polypropylene glvcol Dilauryl thiodipropionate Sodium hyaluronate Polvquatemium -4 -6 -7. -10 Ethanolamine sulfite, E thioglycolate Sodium isostearoyl lactviate
Sodium lactate, S lauroyl lactviate, S PCA Polvquaιernιum-22. 28. -39 Ethanolamine thiolactate ate Sodium polyglutamate PPG-5-ceteth- 10 phosphate Glvceryl thioglvcol
Sodium stearovl lactviate Propyltπmonium hvdrolvzed collagen Hydroxvmethvl dioxoazabicvclooctane
Sorbitan laurate Propvltπmonium hvdrolvzed sov protein Jojoba esters
Sorbitan sesquiisostearate Propyltπmomum hvdrolvzed wheat protein Monoethanolamine thiolactate Quaternιum- 18 -75. 81, -82 Shea butler, ethoxvlated Sorbitol Quaternιum-79 hvdrolvzed keratin Sodium thioglycolate Sphingoiipids
TEA-PCA Quaternιum-79 hvdrolyzed silk Thioglycerin
Urea Sambucus mgra extract, oil Thioglycotic acid Sesamidopropalkomum chlonde Thiolactic acid Hydrotrope Silicone quatemιum-1,-8 Ammonium cumenesulfonate Sodium cocoamphoacetate Humectant Ammonium xvlenesulfonate Sodium cocovl hvdrolvzed collagen Acetamide MEA Cetamtne oxide Sodium polvstvrene sulfonate Acetvl monoethanolamine Cocamidopropvlamine oxide N-Soya-(3-amιdopropvl)-N.N-dιmethvl-N-ethvl 6-(N-Acetvlamιπo )-4-oxvhexvltπmomum chlonde Lauramine oxide ammonium ethvl sulfate Adenostne phosphate Potassium toluenesulfonate Steapvπum chloπde Ammonium lactate PPG-2-ιsodeceth-4. -6, -9. -12 Stearalkonium chloπde Atelocollagen Sodium αimene sulfonate Stearamidopropvl dimethvlamine Calcium pantothenate Sodium laureth- 13-carboxvlate Steardimomum hvdroxvpropyl hvdrolvzed wheat Calcium stearovl lactviate protein Carboxvmethyl chitin Sodium toluene sulfonate Steanπmonium chloπde Carboxvmethvl chitosan succinamide Sodium xvlene sulfonate
Steaπrimonium hvdroxvethvi hvdrolvzed collagen Chitosan PCA Tndecedι-19-carboxvlιc acid N-Stearvl-( 3-amιdooropvl)-N N-dimethvl-N-ethvl Cholestervl hvdroxvstearate Intermediate ammonium ethv I sulfate Collagen amino-polvsiloxane hvdrolvzate
Caprv lie acid Stenocalvx micalu extract Colloidal oatmeal
Deceth-3
Copper PCA methvlsilanol Sulfur Dtethvl succmate Tallowbenzv Idimethvtammυnium chlonde, Dimethicone copolvol laurate
Dimethvlaminopropviamtne hvdrogenated Dipotassium glvcvπhizinate
Ethvl ester of hvdrolvzed silk DM hvdantoin Tallowtπmonmm chlonde
Fattv quaternary amine chlonde complex Dodecvlbenzene sulfonic acid Tea (Camellia sinensis) oil
Glucose glutamate Ethvlene dichloπde TEA-cocovl hvdrolvzed sov protein
Glycereth-4.5-lactate 4-Fluoιo 3-nιtro aniline Thenovl methionate
Glycereth-7. -12. -26 Lauramine Tnmethvlsilvlamodtmeihicone
Glycenn Methvl benzoate. M cocoate Wheat amino acids
Honey extract Mcdivl isostearate. M laurate
Hvdrogenated passion fruit oil Methvl mvnstate. M palmitate
Hair set resin polymer Hydrolvzed casein Oletc aαd
Acrvlates/acrv lamide copolvmer Hvdrolvzed flbronectin Ricinoleic acid Acrvlates PVP copolvmer Hydrolvzed glycosaminoglycans Tall oil acid Acrvlates/hvdroxvesters acrvlates copolvmer Hydrolvzed oat protein Tallow acid Acrvlates/octvlarvlamide copolvmer Hvdrolvzed silk AMP-acrvlates copolvmer Hydrolvzed sov protein Lathering agent Butvlester ot PVM-MA copolvmer Hydroxvpropvl chitosan Ammonium cocovl sarcosmate Carboxvlated vinvlacetate terpolvmer Hvdroxvpropyltnmonium hvdrolvzed casein Ammonium C12-15 alkvl sulfate Diglvcol/CHDM/isophthalates/SIP copolymer Hydroxypropvltπmonium hvdrolvzed sdk Ammonium laurovl sarcosmate Eclipta alba extract Hydroxvpropyltπmonium hvdrolvzed sov protein Cocamide MEA ethoxvlate Ethyl ester of PVM MA copolvmer Hydroxypropvltπmonium hydrolyzed wheat protein Cocamidoprop l dimethylaminohvdroxvpropvl Hvdroxvpropvl chitosan Keratin amino acids hydrolvzed collagen Isopropvl ester ot PVM/MA copolvmer Lactamide DGA, MEA Laurovl sarcosine Octvlacrvlamide acrvlates/butvlammoethvl Lactamtdopropyl tπmonium chloπde Mvnstov 1 sarcosine methacrvlate copolvmer Lactic acid Sodium cocovl sarcosmate Polvmethacrvlamidopropvltπmomum chlonde Sodium laurovl sarcosmate
Lactose Polvpropvlene glvcol oligosuccinate Sodium methyl cocovl taurate
Laurovl lvstne PVP Sodium mvnstovi sarcosmate
Maltitol
PVP/dimethvlaminoethvlmethacrvlate copolvmer TEA-cocovl sarcosmate
Mannuol TEA-laurovl sarcosmate PVP/Polvcarbamvl polvglvcol ester Methvl gluceth-10 20 PVPΥA coDolv mer Natto gum Lubricant PVP VA inv l propionatc copolv mer Oat (Avι-na saliva) extract, protein Aluminum salt octenvl succmate Sodium polv -rv laie Panthen >l Amodimethicone "? Cosmetic Bench Reference 1996 Functions
Boron mtnde Stearyl dimethicone Lanolm substitute — PEG-80 jojoba acid/alcohol
Calcium aluminum borosilicate Tπisostearyl citrate Lipolyiic — Gelidium caπilagineum
Calcium stearate Tπoletn Oxident — Baπum peroxide. Hydrogen peroxide.
Caprvlic/capπc tπglvceπde Tπsodium HEDTA Urea peroxide
Coceth-7 carboxvlic acid Tπuπdecanom Oxygen carrier — Perfluorodecalm
Coconut (Cocos nucifera) oil Zinc laurate. Z stearate Peroxide stabilizer — Phenacettn. Sodium stannate
Cyclomethicone Scalp snmulant — Birch (Betula alba) leaf extract
Diisodecvl adipate Miscellaneous Sebostaitc — Laminaπa sacchaπna extract
Diisostearvl fumarate Adhesion promoter — Glvcenn/diethvlene glycol/ Shine enhancer — Hydrolyzed wheat protein
Dimethicone copolvol adipate crosspolvmer hvdroxypropyl polvsiloxane
Glyceryl isostearate G oleate Analgesic — Glvcol salicvlate Skin barrier lipid— Ceramide 3, N(27-
Glyceryl polvmethacrvlate Anesthetic — Benzocaine Stearoyloxy-heptacosanoyl) phytosphιngosιπe
Gold of Pleasure oil Ann-elastic — Hydrolvzed Ulva iactuca extract Skm clarφer — Oat (Avena sativa) bran extract
Hyaluromc acid Anti-itchmg — Sodium shale oil sulfonate
Hydrogenated coconut oil Skm purifier — Birch (Betula alba) leaf extract Aπtiacid — Magnesium hvdroxide. Magnesium
Hvdrogenated cottonseed oil Substantmtv — Dimethicone copolyol silicate, Stmethicone
Hydrogenated palm oil bishydroxyethvlamine, Dimethicone Antifoam — Dimethicone silylate, Simethicone
Hydrogenated sovbean cottonseed oil hydroxypropyl tπmonium chloride, Antilψasic — Laminaπa sacchaπna extraα
Hydrogenated sovbean oil Anuprurmc — Coal tar Tπmethyisilvlamodimethicone
Hvdrogenated vegetable oil Antispastmodic — Garlic (Album sativum ) extract Sunless tanning — cetvl tyrosine, Eclipta alba
Hydrolvzed oat flour Antwrinkle — Chinese hibiscus (Hibiscus rosa- extract in while emulsion
Hvdroxvpropvl guar sinensis) extract To e — Kiwi (Actinidia chinensis) fruit extract.
Isodecvl stearate Barrier — Glyceπn/diethvlene glycol/adipate Matπcaπa (Chamomiila recutita) extract
Isopropvl lanolate crosspolymer Orange (Citrus aurantium dulcis) peel extract
Isostearvl diglvcervl succmate
Jojoba esters Cell regeneratio — Glvcoproteins Hvdrolvzed Viscosm stabilizer — Diisodecvl adipate
Lanolin oil Ulva Iactuca extract Spreading agent — Stearvl heptanoate
Laureth-3 phosphate Co-emulsιfie — Cholestervl/behenvl/ocivldodecvl Wound healing — Comfrev (Svmphvtum officinale)
Magnesium mvnstate. M stearate laurovl glutamate Isododecane leaf extract
Mango (Mangifera indica) oil Colloid — Gelatin Waterproofing agent — PVP'eicosene copolvmer.
Mineral oil (Paraffinum liquidum) Cooling agent — Menthvl PCA. Meπthoπe glvceπn PVP hexadecene copolvmer. Tπcontanvl PVP
Mink oil acetal
Monostearvi citrate Detoxφer — Clover (Tπfoltum pratense ) extract Moisture barrier
Neatsfoot oil Dve stabilizer — Uπc acid Acrvlates/octvlarvlamide copolvmer
Oleosteaπne Filler — Mica Betaglucan
Partiallv hvdrogenated sovbean oil Fragrance stabilizer — 2.2'.4.4'- C16-18 alkvl methtcone
PEG-2 stearate Tetrahvdroxvbenzophenone Cholesterol
PEG -4 dilaurate Free radical scasenger — Melanin Glvcolipids
PEG-5M IR filler— Corallina officinalis Isoeicosane
Cosmetic Bench Reference 1996 1.29 Functions
Isohexadecane Emblica otficinalis extract Methvisiianol elastinate, M mannuronate
Lanosterol Ethyl mtnkate Milk amino acids
Octvl pelargonate O stearate Eugenia jambolana extract Mineral oil (Paraffinum iiquidum)
Polyisobutene Evening pnmrose (Oenothera biennis) extract, oil Molvbdenum aspartate
Polvisobutene/isohexapentacontahectane Galla sinensis extract Mounπ apiranga extract
Polvisobutene/isooctahexacontane Ganoderma lucidum oil Natto gum
Silica silvlate Ginseng (Panax ginseng) extract Nclumbium speciosum extract
Tπhydroxvpalmitamtdohvdroxv propyl mvπstyl Gleditsia sinensis extract Neopentyi glycol dicaprate ether Glycereth-12 Oat (Avena sativa) protein Tnmethvlsiloxvsilicate Glyceryl alginate G collagenate Octyl hydroxvstearate
Glyceryl polvmethacrvlate Ophiopogon japomcus extract
Moisturizer Glycolic acid Orange (Citrus aurantium dulcts) peel wax
Acetamidopropvl iπmonium chloπde Glycolipids Palmetto extract
Adenosine tπphosphate Glycosaminoglycans Pantethine
Aesculus chinensis extract Glycosphingolipids Panthenvl ethvl ether
Algae (Ascophvlium nodosum) extract Gnetum amazontcum extract Paraffin
Algae extract Grape (Vms vinifera) seed oil Paπiallv hvdrogenated sovbean oil
Aloe barbadensis A b extract Hazel (Corvlus avellana) nut oil Peanut (Arachis hypogaea) oil
Ammonium lactate Honev extract Pecan (Carva illinoensis) oil
Amntotic fluid Hyaiuronic acid PEG-* -6 8 12
Apple (Pvrus malus) extract Hybnd safflower (Caπhamus nnctoπus) oil PEG-70 mango glyceπdes
Apπcot (Prunus armemaca) kernel oil Hydrogenated castor oil PEG-75 shea butler glvcendes
Argmine PCA Hydrogenated coconut oil PEG-75 shorea butter glvcendes
Atelocoilagen Hydrogenated cottonseed oil PEG- 100 stearate
.Artemisia apiacea extract Hvdrogenated lecithin Peπtaervthπtvl isostearate/caprate/caprvlate/
Astrocarvum murumuru extract Hydrogenated palm oil adipate
Avocado (Persea gratissima I extract oil Hydrogenated polvisobutene Pentaervthπtvl stearate/caprate/caprvlate/adipate
Avocado (Persea eratissima) unsapomfϊables Hydrogenated sovbean oil Pentvlene glvcol
Babassu (Orbignva oleifera) oil Hydrogenated sovbean/cottonseed oil Perfluoropolvmethvlisopropvl ether
Bactπs gasipaes extract Hydrogenated vegetable oil Petrolatum
Bemncasa hispids extract Hydrolvzed carbolipoprotein Petroleum wax
Betaglucan Hydrolvzed collagen Pfaffia spp extract
Betaine Hydrolvzed elastin Pistachio (Pistacia vera) nut oil
Borage (Bυraεo otficinalis) seed oil Hydrolvzed fibronectin Placental protein
Brazil nut (Beπholettia excelsa) extract oil Hydrolvzed glvcosaminoglvcans Plankton extract
C10-30 cholesterol lanosterol esters Hydrolyzed keratin Polvamino sugar condensate
Calcium pantothenate Hydrolvzed milk protein Polvbutene
Calcium protein complex Hydrolvzed oats Polvunsaturated fattv acids
Caprvlic/capric tnclvceπde Hvdrolvzed pea protein Potassium DNA P lactate P PCA
Caprvlic/capπc/lauπc tπglvcende Hvdrolyzed placental protein PPG 8/SMDI copolvmer
Caprvlic/capπc linoleic tπglyceπde Hydrolvzed rice protein PPG-20 methvl glucose ether distearate
Caprv lic/capπc oleic tnglvceπdes Hydrolyzed transgemc collagen Propvlene glvcol dicaprvlate/dicaprate
Cashew (Anacardium occidental ) nut oil Hydrolvzed serum protein Propvlene glvcol dioctanoate
Celasirus pamculata extract Hydrolvzed silk Pumpkin (Cucurbiia pepo) seed oil
Ceramtde 33 (liquid sov extract) Hydrolvzed sweet almond protein Quinoa (Chenopodium quinoa) extract
Chia (Salvia hispamcal oil Hvdrolvzed wheat protein Rapeseed (Brassica campesiπs) oil
Chinese hibiscus ( Hibiscus rosa sineπsis) extract Hvdroxvethvl chitosan Rehmanma chinensis extract
Chitin Inositol Rice (Orvza sativa) bran oil
Chitosan C PCA Isodecvl salicvlate Rose Water
Cholesteπc esters Isostearvl hvdrolvzed animal protein Roval jeliv extract
Cholesterol Jojoba (Buxus chinensis) oil Sacchande isomerate
Cholestervl/behenvl octvldodecvl laurovl glutamate Jojoba esters Saccharomvces Ivsate extract
Cocodimomum hvdroxvpropvl hvdrolvzed collagen Keratin ammo acids Saccharomvces/sov protein terment
Cocodimomum hvdroxvpropvl hvdrolvzed silk Kiwi (Actinidia chinensis) fruit extract Safflower (Caπhamus tincteπus) oil
Cocodimomum hvdroxvpropvl hvdrolvzed wheat Kola (Cola acummata) extract Selenium aspaπate S protein complex protein Kukui (Aleuπtes molaccana) nut oil Seπcin Cocodimomum hvdroxvpropvl silk ammo acids Lactamide DGA. L MEA Serum albumin Collagen Lactic acid Sesame (Sesamum indicum) o l
Collagen amino acids C phthalate Lactobaciilus/whev ferment Shea butter (Butvrospermum parkii) Copper aspaπate C protein complex Lactococcus hydrolvsate Shea butter (Butvrospermum parkn) extract Corn (Zea mavsl oil Lactoyl methvisiianol elastinate Shorea stenoptera butter Cottonseed (Gossvplum) oil Lanolin alcohol Silk amino acids Crataegus cuneata extract Laurvl PCA Sodium carboxvmethvl beta glucan
Lecithin Cucumber (Cucumis sativus) extract Sodium chondroitin sulfate
Lesquerella fendien oil Desamido collaεen Sodium DNA S hvaluronate Dicaprvlvl maleate Liposomes Sodium lactate S PCA
Lysine PCA Ditsocetvl dodecanedioate Soluble collagen Diisostearvl adipate Macadamia ternifolia nut oil Soluble transgemc elastin
Magnesium aspartate Sovbean (Glvcine soja) oil Dimethvl hvaluronate
Maltitol Spheπcal cellulose acetate Dimethvlsilanol hvaluronate
Manganese aspaπate Spondias amara extract Dioctvldodecvl dimer diiinoleate Mango (Mangifera indica) oil Squalene Dioctvldodecvl dodecanedioate Manπan Stomach extract Dipentaervthπtol fattv acid ester Maπne polvaminosacchande Sunflower (Heltanthus annuus) seed oil Dog rose ( Rosa camna) hips extract Mauntella armata extract Superoxide dismutase Dog rose ( Rosa camna 1 seed extract Maximilliana regia extract Tissue extract Echttea εlauca extract Meadowtoam (Limnanthes alba) seed oil Tocophervl acetate T Imoleate Elastin am o aciαs Melaleuca hvpercitolia extract Tomato (Solanum Ivcopersicum) extract
1 30 Cosmetic Bench Reference 1996 Functions
Tormentil (Potentilla erecta) extract Stearyl stearate Ammonium acrylates acrv lonitrogens copolymer
Trehalose Styrene homopolymer AMP-acrylates copolymer
Tπundecanoin Styrene acr l tes copolymer AMP-isostearoyl hydrolyzed collagen
Vegetable oil Styrene PVP copolymer Butylester of PVM-MA copolymer
Walnut lJuglans regia) oil Triisosteann PEG-6 esters Calcium carrageenan
Watercress I Nastuπium otficinale) extract Carboxylated vin lacetate te olymer
Wheat (Triticum vulgare) germ extract, germ oil Plasticizer Ceteareth-2 phosphate
Yarrow (Achillea milleloliumi extract Acetyl tnbutyl curate Ceteareth-D phosphate
Wheat amino acids Acetyl tπethyl citrate Ceteareth-10 phosphate
Yeast (Saccheromvces cerevisiae) extract (Faex) AMP-isostearoyl hydrolyzed wheat protein Cetearelh-29. -34
Yoguπ tlltrate AMPD-isostearoyl hydrolyzed collagen Coco-glucoside
Zinc aspartate Cyclohexane dimethanol dibenzoale Cocodimomum hydroxypropyloxyethyl cellulose
Ziziphus jujuba extract Dibuiyl phthalate Cl2-l3 pareth-4. -9. -23
Diethyl phthalate DEA-ceteareιh-2-phosphate
Naturilizer Diethylene glycol dibenzoate DEA-oleth-5-phosphale
2-Amιnobutanol Diisopropyl sebacate DEA-oleth-20-phosphate
Aminoethyl propanediol Dimethicone copolyol Diglycol/CHDM/isophihalatesVSIP copolymer
Aminomethyl propanediol Dimethyl phthalate Diisopropyl dimer diiinoleate
Aminomethvl propanol Dipropylene glycol dibenzoate Diisostearoyl tπmethylolpropane siloxy silicate
Ammonium carbonate Ethyl ester ol hydrolyzed keratin Diisostearvl dimer diiinoleate
Calcium hvdroxide Glycerol tπbenzoate
Dielhanolamiπe Dilinoleic acid
Glycol
Ethanolamine Dodecanedioic acid/cetearv 1 alcohol/glycol
Hydrolyzed serum protein
Glucamine copolymer
Isocetyl salicvlate l.sopropanolamine Eclipta alba extract
Isopropylamine Isodecvl benzoate Ethyl ester ot PVM MA copolymer
2-Meιhyl-4-hydroxypyrrolιdιne Isoeicosane Emylene/acrylic acid copolymer
Morpholine Isopropyl lanolate EUiylene VA copolymer
Sodium bromate Isostearoyl hydrolyzed collagen Glycerelh-26 phosphate
Succinic acid Lauroyl hydrolyzed collagen Hval uronic acid
Tetrahydroxypropyl ethylenediamtne Maπne collagen Hydrolyzed RNA
Tπethanolamine Monostearyl citrate Hydrolyzed wheat protein polvsiloxane polymer
Trometha ine Neopentvl glycol dibenzoate Hydroxypropyltπmo um hvdrolyzed collagen
Octyl benzoate. O. laurate Hydroxypropyltπmomum hydrolyzed wheat
Oil absorbent PEG-60 shea butter glyceπdes protein
Hydrated silica Pentaerythπtyl tetrabenzoate Laneιh-40
Polymethyl melhacrylate Polyoxyethylene glycol dibenzoate Lauryldimonium hydroxypropyl hydrolyzed soy
Silicon dioxide hydrate Poivpropvlene slvcol dibenzoate protein
Walnut (Juglans regia) shell powder PPG- 12-PEG-50 lanolin Methacrylol ethyl betaine/acrvlates copolvmer
PPG-20 cetyl ether Octylacrylamide/acrylates/butylaminoethv l
Ointment base PPG-20 lanolin alcohol ether me acrylate copolymer
Borage I Borago otficinalis) seed oil Propylene glycol dibenzoate OleUι-2 phosphate
Caprylic/capπc/steaπc tπglyceπde Propylene glycol mvπstvl ether acetate θleth-5 phosphate
Glyceryl cocoate Rice (Oryza sativai bran wax PEG-3 lanolate
Hydrogenated coco-glyceπdes Serum protein PEG-4 stearate
Lanolin Tosylamide/epoxy resm PEG-5M
Mink oil Tπacetin PEG-7 glyceryl cocoate
Oleosieaπne Tnbutyl citrate PEG-8 glyceryl laurate
Tallow Tπethyl citrate PEG-8/SMDI copolymer
Tπmethyl pentanediol dibenzoate PEG-9 castor oil
Opacifier Tπmethylethanetπbenzoate PEG-9M
Barium sultate PEG-11 babassu glyceπdes
C 12- 16 alcohols Polish PEG- 12 palm kernel glyceπdes
Cetearyl octanoate Acrvlates copolymer PEG- 12 stearate
Cetyl mvnstate. C. palmitate Aluminum silicate PEG-14 avocado glyceπdes
Cocamidopropyl lauryl ether Neaisfoot oil PEG-15 glyceryl laurate
Glyceryl distearate Tallow PEG-20 corn glyceπdes
Glyceryl hydroxvstearate PEG-20 evening pnmrose glyceπdes
Glycer l mvnstate. G. stearate Polymer PEG-20 glyceryl oleate
Glycol distearate. G. stearate Acrylamide sodium acrylate copolymer PEG-23 oleate
Magnesium mvnstate Acrylates-VA crosspolymer PEG-23M
PEG-2 distearate. P. stearate Acr lates/acrylamide copolymer PEG-29 castor oil
PEG-2 stearate SE Acrylates h droxyesters acrvlates copolymer PEG-42 babassu glycerides
PEG-3 distearate Acrylates/octylacrylamide copolymer PEG-45 satflower glyceπdes
Propylene glycol mvnstate. P. g. stearate Acryiaιe.s7steareth-20 melhacrylate copolymer PEG-J5M
Stearamide Adipic acid-epoxypropyl diethylenetπamine PEG-60 evening pnmrose glyceπdes
Stearamide DIBA-stearate copolymer PEG-60 hydrogenated castor oil
Stearamide MEA Adipic acid/dimethvlaminohydroxypropyl PEG-75 castor oil
Stearamide MEA-stearate diethylene tπamine copolymer PEG-90M
Stearamidopropyl dimethvlamine lactate Ammonium acrvlates copolymer PEG- 120 distearate
1.31 Functions
PEG- 150 lanolin Powder Benzalkonium chlonde
PEG-160M Acrvlates copolymer, spherical powder Benzεtho um chlonde
PG-hydroxycellulose laurvldimonium chloπde Attapulgite Benzoic acid
PG-hydroxyethvlcellulose cocodimomum chloride Boron nitride Benzyl alcohol
PG-hydroxyethvlcellulose stearyldimonium Calcium aluminum borosilicate Bcπzylparaben chlonde Calcium carbonate 5-Bιomo-5-nιtro- 1,3-dioxane Polyethylene, lonomer Cellulose tnacetate 2-Bromo-2-mtrαpropaπe- 1,3-dιol Polyethylene, micronized Corn (Zea mays) cob powder, starch Butylpaiaben Polyethylene, oxidized Hydrogenated jojoba wax Calcium propionate Polyglyceryl-2 polyhydroxvslearate Magnesium carbonate. M. mvnstate Cetiunomum bromide Polymethacrvlamidopropyltπmonium chloride Magnesium stearate Cetyl pyπdimum chionde Polyquatermum-6. -7. -10, - 11. -22. -39 Mica Chloroxvlenol Polysιlιcone-8 Microcrystalline cellulose Chi otphenesin Potassium alginate Nylon-6 o-Cymen-5-ol
Potassium lauroyl collagen ammo acids Nylon powder Diazolidinvi urea Potassium laurovl hvdrolvzed soy protein Oat (Avena sativa) starch Dichlorobenzvl alcohol Potassium laurovl wheat ammo acids Polyamide 12 Dichlorophene
Diiodomethvltolylsulfone PPG-8/SMDI copolymer Polyethylene
Polymethvl methacrylate Dimethyl hvdroxymethyl pyrazole PPG-12/SMDI copolymer
Dimethyl oxazoltdine PPG-51/SMDI copolvmer Polymethvlsilsesquioxane
Disodium EDTA PVM/MA decadiene crosspolymer PTFE
DMDM hvdantoin PVP/dimethvlaminoethylmethacrvlate copolymer Silica
EDTA PVP VA copolvmer Silk powder
Ervdiorbic acid
Sodium cocovl hydrolyzed wheat protein Spheπcal cellulose acetate
7-Ethyibιcvclooxazolιdιne Steardimonium hydroxypropyl hvdrolvzed wheat Talc
Ethylparaben protein Tapioca dextnn Fomistopsis otficinalis oil Steareth-2 phosphate Zinc laurate Formaldehyde
TEA-acrylates acrylonitrogens copolymer Gluiaral Tosylamide/epoxy resin Powder, absorbent Glvcervl laurate Tosylamide/formaldehyde resin AJuminum starch octenvlsuccinate HEDTA Tπdeceth-5, -6, -7, -8 Clays (white, yellow, red. green, pink) Hexamidine diisethionate
VA/butyl maieate/isobomvi acrvlate copolymer Sorbitol Hexeudine VA/crotonates/vinyl neodecanoate copolymer Tapioca Imtdazoiidinyl urea Vinyl caprolactam PVP/ Isobutylparaben dimethvlam oethvlmethacTvlate copolymer Preservative Isopropyl sorbate Wheat (Triticum vulgare) protein Alcohol Isopropylparabeπ Xanthan gum Ascorbic acid MDM hvdantoin Ascorbyi palmitate Methenammo um chloπde
t
1.32 Cosmetic Bench Reference 1996 Functions
Isυbutane Sodium casemate Liposomes Propane Sodium cocovl hydrolvzed collagen Magnesium sulfate hepta-hvdrate Sodium cocovl hvdrolvzed sov protein Octvldodecvl behenate O mvnstate
Protein Sodium mvπstovl hvdrolvzed collagen bis-Octvldodecvi stearovl dimer diiinoleate
Albumen Sodium oleovl hvdrolvzed collagen Octvldodecvl stearovl stearate -lclocollaaen Sodium stearovl hvdrolyzed collagen Octvl hvdroxvstearate Bletu hvacinlhma extract Sodium undecvlenovl hydrolvzed collagen PEG-3 stearate Chrvsanthemum monfolium extract Sodium TEA-laurovl hvdrolvzed collagen PEG- oleamide Cocodimomum hvdroxvpropyl hvdrolvzed Sodium/TEA-lauroyl hydrolvzed keratin PEG 6 capπc/caprv li glyceπdes collagen Soluble collagen PEG-7 glycervl cocoate Cocodimomum hvdroxvpropvl hvdrolyzed keratin Soluble keratin PEG- 16" Cocodimomum hvdroxvpropyl hvdrolvzed soy Soluble wheat protein Propylene glvcol dipelargonate protein Soy (Glycine sojal protein Cocodimomum hvdroxvpropyl hvdrolyzed wheJt Steurdimomum hvdroxvpropyl hydrolvzed Resin protein collagen Acrylates hvdroxvesters acrvlates copolvmer Cocovl hvdrolvzed collagen Steannmomum hvdroxvethvl hydrolvzed collagen Ethvlene vinvl acetate Cυllueeπ C phthalate TEA-cocoyl hydrolvzed coliagen Glycervl abietate Collagen aπuπo-polvsiloxane hvdrolvzate TEA-cocovl hydrolvzed soy protein Methacrvlol ethvl betaine/acrvlates copolvmer Dcυxvnbonuclcic acid TEA-lauroyl collagen ammo acids 4-Methyl benzenesulfonamide Dc .u ido collagen Polvpropvlene TEA-lauroyl keratin ammo acids Elastin ammo acids Polvquateπιιum- 16 -44 Trachea hvdrolvsate Embrvo extract Sucrose benzoate
Tπethomum hvdrolvzed collaeen ethosulfate
Ethvl ester ol hvdrolvzed animal protein Wheat (Tπticum vulgarel germ extract protein Sequestrant Fibronectin Wheat amino acids Calcium acetate C phosphate C sulfate Gelatin Wheat peptide Encapsulation and entrapment svstems
Human placental protein Wheat protein Pentasodium tnphosphate Hydrolvzed collagen Phosphoπc acid Hvdrolvzed extensin Protein, hvdrolyzed Potassium phosphate P sodium taπrate Hvdrolvzed fish protein Ethvl ester ot hvdrolvzed silk Silicon dioxide hvdrate Hydrolvzed hemoglobin Hvdrolvzed casein Sodium citrate S gluconate Hydrolvzed keratin Hydrolvzed elastin Sorbitol Hydrolvzed lactalbumin Hydrolyzed mushroom (Tπcholoma matsutakei Taπaπc acid Hydrolvzed milk protein extract Tπpotassium EDTA Hvdrolvzed sov flour Hydrolyzed pea protein Tπsodium NTA Hvdrolvzed sweet almond protein Hvdrolyzed nee protein Hydroxvpropvltnmomum hvdrol zed collagen Hvdrolvzed serum protein Silicone Isostearovl hvdrolvzed collagen Hvdrolvzed silk Amino bispropvl dimethicone Keratin Hvdrolvzed sov protein Ammonium dimethicone copolvol sultate Lactotemn Hydrolvzed vegetable protein Amodimethicoπe Lactoglobolin Hvdrolvzed wheat protein Behenoxv dmethicone
Laurv Idimonium hv roxvpropvl h drolvzed collagen Hvdroxvpropyltπmonium hydrolvzed casein C16-18 alkvl methicone Maπne collagen Hydroxvpropvltnmomum hvdrolvzed silk Cetvl dimethicone copolvol Methvisiianol elastinate Hvdroxvpropvltπmυnium hvdrolvzed sov protein CvclomethicoπeDiisostearovl tπmethv lolpropane Potassium abieto l hvdrolv zed collagen Hvdroxvpropvltπmonium hvdrolvzed wheat siloxv silicate Potassium cocovl hvdrolvzed collaeen protein Dnsodecv I adipate Potassium mvπstovl hvdrolvzed collagen Diisostearv l tπmethvlolpropaπe siloxv silicate Potassium oleovl hvdrolvzed collagen Reducing agent Dimethicone Potassium undecv lenovl hvdrolvzed collagen Dimvnstvl thiodipropionate Dimethicone copolvol Propvltnmo um hvdrolvzed collagen Hydrolvzed zein iodized Dimethicone copolvol almondate Propvltπmoπium hvdrolvzed sov protein Hvdrolvzed zein sultuπzed Dimethicone copolvol isostearate Zinc formaldehyde sulfoxvlate Propyltπmonium hvdrol zed wheat protein Dimethicone copolvol olivate D c phthalate Protein hvdrovlsates Dimethicone copolvolamina Quaterntum 79 hvdrolvzed keratin Refattmg ag ent Dimethiconol fluoroalcohol diliπoleic acid
Caprvlic/capπc tπglyceπde PEG . esters Quutemium 79 hvdrolvzed silk Dimethiconoi hvdroxvstearate D stearate Cocamide MIPA Rice peptide Diphenvl dimethicone Diisostearvl dimer diiinoleate RNA Disodium-PG-propvldimethicone thiosulfate Hydorgenated palm kernel glvcendes
Seπim albumin S protein Isopropyl hvdroxvbutvramide dimethicone Isostearvl erucate 1 isostearate Silk powder copolyol Lecithin Methicone
Smoother, Shirάer HaJ? Q γQQ SL
Try our cross-linking conditioner: CRUUA UiMC j | ^,^
7 Century Dr Parsippany NJ 07054
BROOKS INDUSTRIES inc.
Cosmetic Ingredients & Ideas' Proteins
70 Tyler Place. South Plainfield. NJ 07080 USA Tel 908-561-5200 Fax 908-561-9174 Hydrocoll, Solu-Soy, Wheat-Pro n^metu β( nt h R< .e- _nce , OQ6 1.33 Functions
Octamethvl cvclotetrasiloxane Potassium cocovl hvdrolvzed collagen Isodecvl salicylate
Phenvl methicone. P tπmethtcone Retinvl palmitate polypeptide Jojoba (Buxus chinensis) oil
Polvether Tπsiloxane Salvia miltioπfuza extract Ladv's Thistle (Silybum maπanum) extract
Polymethvlsilsesquioxaπe Silt Laminana japomca extract
Polysιltcone-8 Sodium cocovl hvdrolvzed collagen Ligusucum jeholense extract
Quatemιum-80 Soluble transgemc elastin Lipo somes
Silicone quaternιum- 1 -8 Steannmomum hvdroxyethvl hydrolvzed collagen Magnolia spp extract
Sodium-PG-propvl thiosulfate dimethicone Stearyl methicone Mango kernel oil
Stearoxvmethicone/dimethicone copolymer Marsilea mmuia extract
Tπmethvlsilylamodimethicone Skin healing Melaleuca hvpercifolia extract
Calendula officinalis extract Melaleuca uncinata extract
Skin calming agent Glycoprotetns Melaleuca wiisonu extract
Cornflower (Centaurea cvanus) extract Hydrocolvl (Centeila asiatica) extract Methvisiianol tn PEG-8 glyceryl cocoate Fennel (Foentculum vulgare) extract Oat (Avena sativa) extract Oat (Avena sativa) meal Fenugreek extract Sandaiwood (Santalum album extract Oyster (Ostrea) shell extract Linden (Tilia cordata) extract Spearmint (Mentha vmdis) extract Palmitamidodecanediol Valeπan ( Valeπana otficinalis) extraα Pearls (Margaπta margaπta)
Skin lightening/whitening agent Pentahvdrosqualene
Skin cleanser Ascorbic acid polvpeptide Perfluorodecalin
Dog rose ( Rosa ca na) hips extract Bearberrv (Arctostaphvlos uva-urst) extract Perfluoropolvmelhvlisopropvl ether Papava (Caπca papava) extract Hvdroquinone-beta-D-glucopvranoside Petrolatum Peach ( Prunus persica I extract Lemon (Citrus medica limonum) peel extraα PEG-8/SMD1 copolvmer Rose (Rosa multiflora) extract Pearls (Margaπta margaπta) PEG-4 Ebinko ceramides extract Willow (Salix alba) extract Pfaffia spp extract
Skin protectant Phosphohpids
Skin conditioner Acetylmethionvl methvisiianol elastinate Plankton extract
Artemisia apiacea extract Allantoin. A aluminum hvdroxide Polvgonum multiflorum extract
Astrocarvum tucuma extract Aloe barbadensis. A b extract Pongamol
Bactπs gasipaes extract Aluminum starch octenvlsucctnate PPG-12 SMDI Copolvmer
Biotin Anise (Pimpinella antsum ) extract PPG-51/SMDI Copolvmer
Bishvdroxvethvl biscetvl malonamide Arnica montana extract Propyltπmonium hvdrolvzed collagen
Bletia hvacimhina extract Artemisia apiacea extract Quinoa (Chenopodium quinoa) extract, oil
Borage (Borago otficinalis) seed oil Ascorbvl methvisiianol pectinate Salvia m tiorrhiza extract
Borageamidopropvl phosphatidvl PG-dimonium Astrocarvum tucuma extract Sambucus mgra extract chlonde Bactns gasipaes extract Shark liver oil Carbocvstetne Betaglucan Shorea robusota extract Catalpa kaempfera extract Bishydroxvethvl biscetvl malonamide Sodium chondroitin sulfate Coco phosphatidvl PG-dimonium chlonde Bletta hvacimhina extract Soluble transgemc eiastin Cocodimomum hvdroxvpropvl hvdrolvzed keratin C 18-70 isoparatfin Steannmomum hvdroxvethvl hydrolvzed collage- Collagen amino acids Calendula amuπeπsis extract Sterculia platantfolia extract Cyclomethicone Carboxvmethvl chitin Superoxide dismutase
Dimethicone. D copolvol acetate Carcima cambogia extract Trachea hvdrolvsate Emblica otficinalis extract Carrot ( Daucus carota) extract Wheat (Tπticum vulgare) germ extract, proton Equisetum arvense extract Carrot (Daucus carota sativa) oil White netUe ( Lamiurn album) extract Ethvl ester ot hvdrolvzed animal protein Catalpa kaemptera extract Withama sommferum extract Evening primrose I Oenothera biennis ) oil Chenopodium album extract Xanthozvlum bungeanum extract Fomes lometaπus extract Chitosan Zinc oxide Fomistopsis officinalis oil Chrysanthemum moπfolium extract Gelatin Collagen Skin smoothing agent Ginseng hvdroxvpropvltπmonium chloπde Com poppy (Papaver rhoeas) extract Althea otficinalis extract butvlene glvcol Crataegus cuneata extract Coltsfoot (Tussilago farfara) leaf extract Glycoltpids Crataegus monogma extract Comfrev (Svmphvtum officinale) leaf extract Glvcosphingolipids Cypress (Cupressus sempervirens) extraα Plantain (Plantago major) extract Gnetum amazomcum extract Dimethicone Seπcin Honev (Mel) Dimethiconol fluoroalcohoi dilinoleic acid
Hydrolvzed carbolipoprotein Dimethiconol hvdroxvstearate. D stearate Skin softening Hvdrolvzed elastin Dimethvistlanol hvaluronate Clavs (white, vellow red green, pink) Hvdrolvzed pea protein Echitea glauca extract Cucumber (Cucumis sativus) extract Hydrolvzed πce protein Embryo extract Kelp (Macrocvstis pvπfera) extract Hvdrolvzed serum protein Entada phaseoloides extract Peach (Prunus persica) extract Hvdrolvzed silk Equisetum arvense extract Phenethvl dimethicone Hydrolvzed sov protein Euphotoπum fonunei extract Hydrolvzed vegetable protein Euterpe precatoπa extract Skin soothing Hydrolvzed wheat protein Fenugreek extract Calendula officinalis extract Inga edulis extract Fomistopsis officinalis oil. F pinicola extract Cherrv bark extract
Kiwi (Actinidia chinensis) fruit extract Galla sinensis extract Cucumber (Cucumis sativus) extract Laminana japomca extract Gentian (Gentiana lutea) extract Garlic (Allium sativum) extract Lecithin Gleditsia sinensis extract Hyssop (Hyssopus otficinalis) extract
Marsilea minuta extract Glyceryl ncinoleate Jasmine (Jasminum otficinale) extract Nettle (Uπica dioica) extract Glycoiipids Kelp (Macrocvstis pvπfera) extract Palmitamidodecanediol Hierochloe odorata extract Mango kernel oil Pearls ( Margaπta margaπta) Hvalurontc acid Meadowsweet (Spiraea ulmaπa) extract PEG-42 Ebinko ceramides extract Hvdrogenated lecithin Quince (Pvπis cvdoma) seed extract Phenvl tnmeihicone Hvdrolvzed lupine protein Slipperv elm extract Phvtanlnol Hvdrolvzed milk protein Valeπan I Valeπana officinalis) extract
Polvgonum multiflorum extract Hvdrolvzed mushroom iTncholoma maisutake l Willow (Salix aibal extract Poh oujicrnium " 2 "l> extract Witch hazel (Hjmamclis v ireinuna l ur u i
Indi in c s iTroruu .urn m HUM cxirac "t irrovv i chillcJ millclnlium l v πci Functions
PEG- 15 castor oil PPG-3 isosιeareιh-9
Splubilizer PEG- 18 stearate PPG-3 isocetedι-20 acetate
Acetyl monoethanolamine PEG-20 glyceryl isostearate. P. g. laurate PPG-5-cetedι- 10 phosphate
Almond oil PEG-6 esters PEG-20 glyceryl oleate. P. g. stearate PPG-5-ceteth-20
2-Amιnobuιanol PEG-20 methyl glucose sesquistearate PPG _-decyltetradeceth-12. -20. -30
Aminoethyl propanediol PEG-20 sorbitan isostearate PPG-I2-PEG-65 lanolin oil
Aminomethyl propanediol. A. propanol PEG-20 sorbitan tπisosterate PPG- 15 stearyl e er
Apπcot kernel oil PEG-6 esters PEG-24 hydrogenated lanolin PPG- 18 butyl ether
Benzulkυπium chlonde PEG-25 castor oil PPG-24 butvl ether
Butox diulvcol PEG-25 hydrogenated castor oil PPG-26-buteth-26
Butyl glucoside PEG-30 castor oil PPG-33 butvl edier
Butylene glvcol PEG-30 glyceryl cocoate PPG-33-buteth-45
Butyloctanol PEG-30 glyceryl isostearate PPG-40-PEG-60 lanolin oil
Capric-capryhc mono-diglyceπde PEG-30 glyceryl laurate PPG-50 cetyl edier
Capryl caprylylgluco.side PEG-30 glyceryl oleate Propylene glycol dicaprylate. dicaprylate
Caprylic/capπc tπglyceπde PEG-30 glyceryl stearate dicaprate
Caprylic'/capπc/linυleic tπglyceπde PEG-33 castor oil Ricinoleamide DEA
Caprylic/capπc/oleic tπglyceπdes PEG-35 castor oil Ricιnoleth-40
Caprylyl/capryl glucoside PEG-36 castor oil Sodium alpha olefin sulfonate
Cetcareιh-20 PEG-40 castor oil Sodium lauryl sulfate
Ccιeιh-10 PEG-40 glyceryl laurate. P. g. stearate Sodium methylnaphthalenesulfonate
Cet l PPG-2 ιsυdeceth-7 carboxylate PEG-40 hydrogenated castor oil Tπedianolamine
Cholesterol PEG-40 hydrogenated castor oil PCA isostearate Trioctanoin
Corn oil PEG-6 esters PEG-40 sorbitan diisostearate Tromediamine
Decaglycerol monodioleate PEG-45 palm kernel glyceπdes
Dicthanυlamine PEG-48 hydrogenated castor oil Solvent
Dιlaurcth- 10 phosphate PEG-50 easior otl Acetic acid
Dimethyl octynediol PEG-50 hydrogenated castor oil Acetone
Dιoleth-8 phosphate PEG-60 almond glyceπdes Alcohol. A. denat.
Glycereth-7 -26 PEG-60 castor oil Benzophenone
Glyceryl caprylate. G. dilaurate PEG-60 corn glyceπdes Butoxydiglycol
Glyceryl caprylate/caprate PEG-60 glyceryl isostearate. P. g. stearate Butyl acetate
Isoeicosane PEG-60 hydrogenated castor oil n-Butyl alcohol
Isopropunυlamine PEG-60 lanolm Butyl mvnstate. B. stearate lsosteareth-20 PEG-70 manεo alyceπdes Butylene glycol
Laneth-5. - 15 PEG-75 lanohn " C9- 11 isoparatfin
Laureth-23 PEG-75 shea butter glyceπdes CIO- 11 isoparaffin
Methylated cyclodextπn PEG-75 shorea butter glyceπdes C10-13 isoparatfin
Myreth-3 PEG-SO hydrogenated castor oil Caprylic aicohol
Myreth-3-octanoate PEG-80 jojoba acid/alcohol Castor (Ricinus communis) oil
Nonoxynol- 10. - 12. - 14. -40. -50 PEG-SO sorbitan laurate Cetearyl octanoate θctoxynol- 1 1. -40 PEG- 100 castor oil Cetyl stearyl octanoate
Oleoamphotiydroxypropylsulfonate PEG- 100 hydrogenated castor oil Chlorobutanol θleth-3. -5. - 10. - 15. -20. -25. -50 PEG- 1 0 jojoba acid/alcohol Decyl alcohol θleth-20 phosphate PEG-200 tπhydroxysteaπn Diediylene glycol
PEG-4. -6. -8. -12. -16. -20. -32. -40. Poloxamer 407 Diediylene glycol dibenzoate
PEG-4 dilaurate Polyglyceryl-3 oleate Diethyl sebacate
PEG-ή capπc/capn. lie glvcendes Polyglyceryl-6 dioleate Diisocetyl adipate
PEG-6 methvl ether Polyglyceryl- 1 O decaoleate. P. tetraoleate Diisopropyl adipate. D. sebacate
PEG-8 distearate Polysorbate 20. 60. 80 Dimethyl phthalate
PEG- 12 laurate PPG-2-ιsodeceιh-4. -6. -9. -12 Dipropylene glycol
Pigments • Preservatives • Surfactants • Emulsifiers • Emollients • Esters • Proteins • Lanolin
.
Aloe Vera • Jojoba Oil • Botanicals • Pigments • Preservatives • Surfactants • Emulsifiers Functions
Dipropylene glvcol dibenzoate Glyceryl diisostearate, G. stearate SE Supertatting agent
Ethoxvdiglvcol Glyceryl mono-di-tπ-caprylate L oleamide DEA
Ethvl acetate. E. lactate Hydrogenated coco-glyceπdes PEG-20 almond giyceπdes
Ethvl mvnstate. E oleate Hydrogenated C12-18 tπglyceπdes PEG-60 lanolin
2-Ethvlhexvl isostearate Hydrogenated tallow glyceπdes PEG-75 lanolin
Glvceπn Hydrolyzed oat flour
Glvcofurol Hydroxvoctacosanvl hvdroxystearate
Surfactant
Heptane Karaya (Stencuha urens) gum
Alkvl dimethvl betaine
Hexvl alcohol aureth-3
Maltitol Alkyldimethylamine oxide
Hexvlene glvcol
Methylated cvclodextπn Ammonium cocovl sarcosmate
Isobutvl stearate Ammonium C12-15 alkyl sulfate
Isocetvl salicvlate Oleamide
PEG-40 stearate Ammonium dimethicone copolyol sulfate
Isodecvl benzoate, I isononanoate
PEG-40/dodecyl glycol copoivmer Ammonium laureth sulfate
Isodecvl octanoate. I. oleate
Perfluoropolymethvlisopropyl ether Ammonium laureth- 12 sulfate
Isododecane
Polvethviene paste Ammonium laureth sulfate
Isoeicosane
PPG-5 lanolin wax Ammonium laurovl sarcosmate
Isohexadecane 7-buteth-10 Ammonium laurvl sulfate, A 1 sulfosuccmate lsopropvl alcohol. I mvnstate PPG- 10 cetyl ether phosphate Ammonium mvreth sulfate
Isostearvl stearovl stearate PPG-
Propylene carbonate, P. glycol alginate Ammonium nonoxynol 4 sulfate
Laureth-2 acetate ecadiene crosspolymer Azelamide MEA
Methoxvdiglvcol PVM/MA d
Sodium acrvlates vinvl isodecanoate crosspolymer C20-40 alcohol ethoxylate
Methoxvisopropanol
Sodium carbomer C30-50 alcohol ethoxvlate
Methvl alcohol
Sorbitan laurate C40-60 alcohol ethoxvlate
Methvl propanediol
Steanc hvdrazide Calcium dodecvlbenzene sulfonate
Methvlene chloπde
2^',4,4'-Tetrahydroxvbenzophenoπe Calcium laurate
MEK
Tπcapπn Ceteareth-2 phosphate
MIBK Tπcaprylin Ceteareth-5 phosphate
Morpholine
Tπlaunn Ceteareth-10 phosphate
Octyl benzoate, 0 isononanoate Tnmyπstm Cetoleth-25
Octvl laurate. O palmitate Tπpalmittn Cetvl betaine. C phosphate
Octyldodecvl lactate Tnsteaπn Cocamide MEA ethoxvlate
Olive oil PEG-6 esters Cocamidopropyl betaine. potassium salt
Peanut oil PEG-6 esters Stimulant Cocamidopropvl betaine ammonium salt
Pentane
Capsicum frutescens extract Cocamidopropyl hvdroxv sultaine
Petroleum distillates Eleuthero ginseng (Acanthopanax senticosus) Cocamidopropyl hydroxy sultaine. ammonium salt
PEG-6 methvl ether extract Cocamidopropyl hvdroxv sultaine. potassium salt
PEG- 12 Guarana (Paullima cupana) extract Cocamidopropylamine oxide
PEG-20 hvdrogenated castor oil Laαøcoccus hydrolvsate Coceth-7 carboxvlic acid
PEG-33 castor oil Methvisiianol elastinate Coco-glucostde
PEG-50 glycervl cocoate Methvisiianol hvdroxvproline aspaπate Cocoamphodiacetate laurvl-laureth sulfate
Polyglycervl-2 dioleate TEA-hvdroiodide Cocoamphodiacetate laurvl sulfate
Polyglycervl-3 diisostearate Tocopheryl mcotinate Cocoamphodiacetate tπdeceth sulfate
Polvoxvethvlene glycol dibenzoate Urocamc acid Coco phosphatidvl PG-dimonium chloπde
Polvpropvlene glvcol dibenzoate
Yeast (Saccheromvces cerevisiae) extract (Faex) N-Cocovl-(3-amιdopropvl)-N,N-dιmethvl-N-ethvl
PPG-2 mvπstvl ether propionate Zedoarv (Curcv a zedorana) oil ammonium ethvl sulfate
PPG-3 Zinc DNA Cocovl glutamic acid
PPG-20 lanolin alcohol ether Cocovl hvdrolyzed sov protein
Propvl alcohol Sunscreen Cocovl hvdroxvethvl lmidazohne
Propvlene carbonate Basϋ (Basiiicum santum) oil extract Cll-15 pareth-9. -12. -20, -30. -40
Propvlene glvcol Basil (Ocimum basiiicum) extract C12-13 pareth sulfate
Propvlene glvcol dibenzoate Benzophenone-3 -4 C12-13 pareth-5 carboxylic acid
Propvlene glvcol methvl ether 3-Benzvlιdene camphor C12-15 pareth-12
Propvlene glvcol mvnstate Borojoa sorbihs extract C14-15 pareth-8 carboxvlic acid
Pyπdine C12-15 alkvl benzoate DEA-oleth-5-phosphate
Sesame (Sesamum indicum) oil Coffee (Coffea arabica) bean extraα DEA-oleth-20-phosphate
Stearvl heptanoate Ethyl salicylate Deceth-3. -6, -8
Toluene Glyceryl PABA Decvltetradeceth-25
Xylene Homosalate Dιceteareth-10 phosphoπc acid
SPF booster Hydroquιnone-beta-D-glucopvranosιde Dimedncone copolvol
Isoamvl p-methoxvcinnamate
Borojoa sorbihs extract Dimedncone copolvol almondate. D c isostearate
Isopropvlbenzyt salicvlate
Isohexadecvl salicvlate Dimethicone copolvol laurate. D c ohvate
Job's tears (Coix lacrvma-jobi) extract Dimethicone copolyol phthalate
Stvrene/acrvlates copolvmer
Menthvl anthramlate Dimethicone copolyolamine
Titanium dioxide
Octyl dimethyl PABA. 0 methoxvcinnamate Dimedncone propvl PG-betaine
Yeast (Saccheromvces cerevisiae) extract (Faex) Octvl salicvlate, O tπazone Dιoctvldodeceth-2 laurovl glutamate
Oryzanol
Stabilizer Dioctvldodeceth -5 laurovl glutamate
Pansy (Viola tπcolor) extract
Acrvlates- VA crosspolymer Dioctvldodecyi laurovl glutamate
PEG-25 PABA
Acrylates/ceteth-20 methacrvlates copolymer Disodium caprvloamphodiacetate
Phenyibenzimidazole sulfomc acid
Acrvlates/steareth-20 methacrvlate copolvmer Disodium cocoamphodiacetate
Rice (Orvza sativa) bran oil
Acrylates/vmvl isodecanoate crosspolymer Disodium hydrogenated tailow glutamate
TEA -salicvlate
Alkvldimeihvlarome oxide Disodium laneth-5 sulfosuccmate
CIO polvcarbamvl polyglvcol ester Titanium dioxide Disodium lauramido MEA-sulfosuccinate
Calcium alginate Disodium laureth sulfosuccmate
Cocamidopropvl dimethvlamine lactate Sunscreen UVB Disodium oleamido MIPA-sulfosuccinate
Cocamine oxide Benzophenone-5 Disodium oleamido PEG-2 sulfosuccmate
Colloidal silica sols Eclipta alba extract Disodium oleth-3 sulfosuccmate
Cvclodextπn PEG-25 PABA Disodium πcinoleamido MEA-sulfosuccinate
Disodium EDTA Steareth- 100 Disodium tallamido MEA-sulfosuccinate
Gellan tzum Tπdecvl salicvlate Dιsteareth-2 laurovl glutamate
■ osmetic β πcn Reference 1996 1.37 Functions
Dιsteareth-5 lauroyl glutamate PEG-80 jojoba oil. P. sorbitan laurate Sodium lauroyl glutamate
Ethoxylated lattv alcohol PEG- 120 jojoba oil Sodium lauroyl hydrolyzed collagen
Ethoxylated glycerol sorbitan saturated fatty acid Pentasodium tπphosphate Sodium lauroyl sarcosmate. S. 1. taurate ester Poloxamer 101. 122 Sodium magnesium laureth sulfate Ethoxylated glycerol sorbitan unsaturated fatty Polyglyceryl-2 dioleate Sodium methyl cocoyl taurate acid ester Polystloxane-polyether copolyer Sodium methyl oleoyl taurate Glycereth-25 PCA isostearate Potassium cocoyl glvcinate Sodium mynstoyl glutamate Glycereth-26 phosphate Potassium cocoyl hydrolyzed collagen Sodium mynstoyl hydrolyzed collagen Glyceryl hydroxvstearate Potassium C9-I5 phosphate ester Sodium mvπstoyl sarcosmate Hydrogenated tallowoyl giutamic acid Potassium lauroyl hydrolyzed collagen Sodium myπstyl sulfate Isopropyl hydroxybuiyramide dimethicone Potassium laurvl sulfate Sodium nonoxynol-6 phosphate
Potassium mynstoyl hydrolvzed collagen Sodium octoxynol-2 ethane sulfonate copolyol Potassium oleovl hydrolyzed collagen Sodium octyl sulfate Lauramidopropvl betaine Potassium palmitate Sodium oleovl hydrolyzed collagen Laureth- 1. -2. -3. -4 . -7. -12. -16 Potassium undecvlenovl hydrolyzed collagen Sodium stearoyi hydrolyzed collagen Laurεth-3 carboxvlic acid. L. phosphate PPG-2-ιsodeceth-4 -6 -9 -12 Sodium tπdeceth sulfate Laureth-5 carboxylic acid PPG - C12-I8 pareth-I l Sodium undecylenoyl hydrolyzed collagen Laureth- 11 carboxylic acid Protein hydroylsates Sodium TEA-lauroyl hydrolvzed collagen Lauroyl sarcosine Quaιemιum-80 Sodium TEA-lauroyl hydrolyzed keratin
Lauryl dimethvlamine cyclocarboxypropyloleate Quilla a saponana extract Sorbitan isostearate Lauryl hydroxyethyl imidazoline Raffinose laurate. R. mvnstate. R. oleate Stearovl sarcosine Linoleamide DEA RafFinose palmitate. R. stearate Sulfated castor oil Magnesium laureth-8 sulfate Ricinoleamidopropyl betame TEA-cocovl glutamate Meroxapol 105. 171. 172 Stlicone quaιemιum-1. -8. -9 TEA-cocovl hydrolyzed collagen MEA-lauryl sulfate Sodium alpha olelin sulfonate TEA-cocovl hydrolyzed sov protein Mixed isopropanolammes mvnstate Sodium cocoamphoacetate TEA-C12-15 alkyl sultate Myreth-7 Sodium cocoyl hydrolyzed wheat protein TEA-hydrogenated tallow glutamate
Mynstoyl sarcosine Sodium cocovl isethionate TEA-lauroyl glutamate
Sodium C 12- 13 sulfate Myπstyl alcohol TEA-lauroyl keratin am o acids
Sodium C12-I4 pareth-2 sulfate Noπoxynol-7. -9. -13. -15 TEA-lauroyl sarcosmate
Sodium C 12- 15 pareth-3 sulfonate Nonoxynol- 10 carboxylic acid TEA-lauryi sulfate
Sodium C 12- 15 pareth-7 carboxylate θctoxynol-10. -12 TEA- vπstovl hvdrolvzed collagen
Sodium C 12- 15 pareth-7 sulfonate θctyldodeceth-10. -16 Tocophereth-5 -10 -18 -20 -30 -50 -70
Sodium C 12- 15 pareth-8 carboxylate Oleovl sarcosine Tπdeceth-7 carboxylic acid
Sodium C 12- 15 pareth- 15 sulfonate θleth-2 phosphate Tπdeceth-9
Sodium C 12- 18 alkyl sultate θleth-5 phosphate Trideceth-19-carboxylιc acid
Sodium C 13- 17 alkane sultonate Oleyl betaine Tridecyl ethoxylate
Sodium C14-I6 olefin sulfonate
Oleyl hvdroxyethvl imidazoline Triedianolamine C 10- 14 sulfate
Sodium cetearyl sulfate Palmnamine oxide Tnlauryl phosphate
Sodium cetyl oleyl sulfate Wheat germamtdopropyl betaine Palmityl betaine Sodium coco-tallow sulfate PCA ethvl cocoyl arginate Yucca vera extract
Sodium cocoyl glutamate PEG-7 hydrogenated castor oil Sodium cocovl hydrolyzed collagen PEG-8 caprvlic/capπc glyceπdes Suspending agent
Sodium cocoyl hydrolvzed soy protein Acrylates/ceteιh-20 meihacrylaies copolymer PEG-8 laurate Sodium cocovl sarcosmate PEG-8 stearate Acrylates steareth-20 melhacrylate copolymer
Sodium dimethicone copolyol acetyl PEG-15 glvcerv l stearate Algin memyltaurate PEG-25 elvcei I isostearate Bentomte Sodium hydrogenated tallow glutamate PEG-27 ianoliri ClO polycarbamyl polyglycol ester Sodium isodecvl sulfate PEG-30 lanolin Calcium alginate Sodium laureth-5 carboxvlate PEG-40 castor oil Carbomer. C.934 Sodium laureth- 11 carboxylate PEG-40 glycervl stearate Caπageenan tChondrus cπspus) Sodium laureth- 13-carboxylate PEG-40 jojoba oil. P. lanolin Sodium laureth sulfate Cellulose gum PEG-60 glyceryl isostearate. P g. stearate Sodium lauroamphoacetate Cetyl hydroxyethylcellulose
OUR NAME IS MclNTYRE
OUR GAME IS AMPHOTERICS
MclNTYRE 24601 Governors Highway • University Park, IL 60466
GROUP LTD. (708) 534-6200 • FAX: (708) 534-6216 • 1-800-645-6457 Functions
Functions
Steareth-10 ally I ether/acrvlates copolymer Gold of pleasure oil Ceresm
Steaπc acid Grape (Vltis vimfera) seed oil Cetyl dimethicone, C. isooctanoatc
Stearvl alcohol Hazel (Corylus avellana) nut oil Dialkyldimethvlpolysiloxane
Synthetic beeswax Hybnd sunflower (Helianthus annuus) oil Dimethiconol hydroxvstearate
Tallowamide MEA Hydrogenated coconut oil Dimethiconol stearate
TEA-acrvlates/acrvlonitrogens copolvmer Hydrogenated cottonseed oil Hydrogenated castor oil
Tragacanth (Astragalus gummifer) gum Hydrogenated vegetable oil Hydrogenated cottonseed oil
Tπbeheπin Jojoba (Buxus chinensis) oil Hydrogenated jojoba oil. H j. wax
Tnhydroxysteaπn Kukui (Aleuntes molaccana) nut oil Hydrogenated palm kernel oil
Tromethamine magnesium aluminum silicate Macadamia lemifolia nut oil Hydrogenated rapeseed oil
Wheat germamide DEA Meadowfoam (Limnanthes alba) seed oil Hydrogenated πce bran wax
Wheat germamidopropyl betaine Mexican poppy oil Hydrogenated vegetable oil
Xanthan gum Palm (Elaeis guineensis) kernel oil Isooctadccvl isononanoate
Japan (Rhus succedanea) wax
Paπiallv hydrogenated sovbean oil
Thixotrope Jojoba esters
Peach (Prunus persica) kernel oil
Bentonite Montan (Montan cera) wax
Peanut (Arachis hvpogaea) oil
Hectoπte Ouπcury wax
Pecan (Carya lllinoensis) oil
Sodium magnesium silicate Ozokeπte
Pumpkin (Cucurbita pepo) seed oil
Stearalkomum bentonite Polyglycervl-3 beeswax
Quinoa (Chenopodium quinoa) oil Spermaceti
Rapeseed (Brassica campestns) oil
Toner Stearoxvmethicone/dimethicone copolymer
Rice (Orvza sativa) bran oil
Althea officinalis extract Stearoxvtπmethvlsilane
Safflower (Caπhamus unctonus) oil
Clover (Tπfolium pratense) extract Synthetic candeiilla wax
Seabuckthorn oil
Dog rose ( osa camna) hips extract Synthetic camauba
Sesame (Sesamum lndicum) oil
Ginseng ( Panax ginseng) extract
Sisvmbπum ino oil Wetting agent
Horsetail extract Soybean (Glvcine soja) oil Bcnzalkomum chlonde
Lemon btoflauonoids extract
Sunflower (Helianthus annuus) seed oil Benzcthonium chloπde
Meadowsweet (Spiraea uimaπa) extract
Walnut (Juglans regia) oil Cetalkonium chloπde
Nettle (Uπica dioica) extract
Wheat (Tπticum vulgare) germ oil Ceteareth-20
Rose (Rosa multtflora) extract
Wild borage oil Ceteth-20
Rosemarv (Rosmaπnus officinalis) extract Cetyl pyπdimum chlonde
Vitamin
UVA absorber Cocoamphodipropionic acid
Aescuius chinensis extract Decaglycerol monodioieate
Benzophenone- l -2. - , -4. -6. -8, -9, -11. -12 Ascorbic acid Deceth-9
Butvl methoxvdibenzovlmethane Ascorbic acid polvpeptide Dihydroabietvl methacrvlate
Corallma otficinalis Ascorbvl palmitate Dimethicone copolvol methvl ether
Isopropvl dibenzovlmethane Biotin Dimethicone copolyol phthalate
Menthvl anthranilate Calαum pantothenate Dioctvl sodium sulfosuccmate
2.2',4,4'-Tetrahvdroxvbenzophenone Cholecalciferol Ethyl hvdroxvmethvl olevl oxazoliπe
Titanium dioxide Cyanocobalamin Hydroxvlated milk glvcendes
Zinc oxide Eclipta alba extract lsolaureth-6
Embiica officinalis extract
UVB absorber Lanolin acid
Equisetum arvense extract Laurvl pvrrolidone
Argania spinosa oil Ergocalciferoi Lecithin
Benzophenone-l -2 -3 -4 -6 -9 -11 Esculin Methvi hvdrogenated rosinate
Corallma officinalis Ethvl Imoleate Methvl rosinate
DEA-methoxvcinπamate Folic acid Nonyl nonoxvnol-5
Drometπzole Laminaπa japomca extract θctoxvnol-8, 70
Ethvl dihvdroxvpropvl PABA Marsilea minuta extract Oleth- 15
Etocrvlene Melaleuca bracteata extract θleth-20 phosphate
Homosalate Menadione PEG-9 castor oil
Isoamvl p-methoxvcinnamate Nasturtium sinensis extract PEG-15 castor oil
Isopropyl methoxvcmnamate Nelumbium speciosum extract PEG-20 glycervl stearate
Isopropvlbenzvl salicvlate Niacin PEG-20 sorbitan tπisosterate
4-Methvlbenzvlιdene camphor Niacinamide. N ascorbate PEG-45 palm kernel glyceπdes
Octocrvlene Ntcotinamide PEG-60 almond glyceπdes. P com glyceπdes
Octπzole Nicotinic acid PEG-60 shea butter glyceπdes
Octyl dimethvl PABA Ocimum basiiicum extract PEG -70 mango glycendes
Octvl methoxvcmnamate Panthenyl tnacetate PEG-75 shorea butter glyceπdes
Octvl salicvlate. O tnazone Pantothemc acid PEG-80 sorbitan laurate
PABA Phytonadione Poloxamer 123. 181, 182. 184, 235, 34
PEG-25 PABA Pyπdoxine HCl Polvether tπsiloxane
Phenvlbenzimidazole sulfonic acid Retinol Polyglvcervl-3 oleate
Shea butter, ethoxvlated Retinyl acetate. R palmitate Polyglyceryl-6 dioleate
TEA-salicylate Retinyl palmitate polvpeptide Polyglyceryl- 10 tetraoleate
Titanium dioxide Retin l propionate Polysorbate 60, 80
TnPABA panthenol Riboflavin tetraacetate PPG-2-ιsodeceth -4, -6, -9, -12
Zinc oxide Sodium ascorbate PPG-10 lanolin alcohol ether
Thiamine HCL Propylene glycol
Vegetable oil Tocopherol Sodium butoxyethoxv acetate
Apπcot (Prunus armemaca) kernel oil Tocophervl acetate, T succmate Sodium capryloamphohvdroxypropylsulfonate Avocado (Persea gratissima) oil Sodium decyl diphenvl ether sulfonate Baobab oil Wax Sodium dodecvidiphenvl ether sulfonate
Calendula otficinalis oil Bavbeπv (Mvπca ceπfera) wax Sodium laurvl sulfate Chaulmoogra I Taraktogenos kurzu) oil Behenoxv dmethicone Sulfated castor oil Coconut I Cocos nuciferai oil C16-18 alkvl methicone Tπisocetvl citrate Corn i Zea mavsl oil Candeiilla (Euphotbia ceπfera) wax Tπisosteaπn PEG-6 esters Cottonseed i Gossv pluml oil Cαmauba (Copeπiicia ceπfera) wax Yucca vera extract

Claims

Cl aims : 1. A cosmetic composition, comprising: a cosmetically acceptable carrier, comprising a reverse thermal viscosifying polymer network comprising at least one poloxamer component randomly bonded to at least one poly(acrylic acid) component said polymer network capable of aggregation in response to a change in temperamre; and a cosmetically active agent which imparts a preselected cosmetic effect, said carrier and said agent disposed within an aqueous-based medium.
2. A cosmetic composition for topical application, comprising: a cosmetically acceptable carrier, comprising a reverse thermal viscosifying polymer network comprising at least one poloxamer component capable of aggregation in response to a change in temperature randomly bonded to at least one poly(acrylic acid) component; and a cosmetically active agent selected to treat imperfections or disorders of the skin, said carrier and said agent disposed within an aqueous-based medium.
3. The cosmetic composition of claim 1 , wherein the cosmetic composition is a shampoo and the cosmetically active agent comprises a cleansing surfactant.
4. The cosmetic composition of claim 1, wherein the cosmetic composition is a moisturizer and die cosmetically active agent comprises a moisturizer.
5. The cosmetic composition of claim 1, wherein the cosmetic composition is a sunscreen and the cosmetically active agent comprises a uv-absorbing agent.
6. The cosmetic composition of claim 1, wherein die cosmetic composition is an acne cream and me cosmetically active agent comprises an antiacne agent.
7. The cosmetic composition of claim 1, wherein die cosmetic composition is a hair straightener and die cosmetic agent comprises a base for increasing the pH.
8. The cosmetic composition of claim 1, wherein the cosmetic composition is a sunless tanning lotion and die cosmetically active agent comprises skin tinting agent.
9. The cosmetic composition of claim 1. wherein d e cosmetic composition is an antiperspirant and me cosmetically active agent comprises aluminum chlorhydrate.
10. The cosmetic composition of claim 1, wherein die cosmetic composition is a shaving cream and me cosmetically active agent comprises an emollient and a foaming surfactant.
11. The cosmetic composition of claim 1 , wherein d e cosmetic composition is a face cosmetic and me cosmetically active agent comprises a pigment.
12. The cosmetic composition of claim 1 or 2, wherein the cosmetic agent comprises a hydrophobic material, wherein d e cosmetically acceptable carrier stabilizes d e hydrophobic material in die aqueous medium.
13. The cosmetic composition of claim 2, wherein said cosmetic agent selected to treat imperfections or disorders of die skin is selected from the group consisting of acidulents, antiacne agents, anti-aging agents, anti-inflammatories, anti- irritants, antioxidants, depilatories, detergents, disinfectants, emollients, exfoliants, humectants, lubricants, moisturizers, skin conditioners, skin protectants, skin lightening agents, skin soothing agents sunscreening agents and tanning accelerators and mixtures thereof.
14. The composition of claim 4, wherein said composition fuither comprises a cosmetic agent selected from the group consisting of humectants and emollients.
15. The composition of claim 1 or 2. further comprising one or more additives selected from the group consisting of preservatives, abrasives, acidulents, antiacne agents, anti-aging agents, antibacterials. anticaking, anticaries agents, anticellulites. antidandruff, antifungal, anti-inflammatories, anti- irritants, antimicrobials, antioxidants, astringents, anitperspritants, antiseptics, antistatic agents, antringents, binders, buffers, additional carriers, chelators. cell stimulants, cleansing agents, conditioners, deodorants, dipilatories, detergents, dispersants, emollients, emulsifiers. enzymes, essential oils, exfoliants, fibers, film forming agents, fixatives, foaming agents, foam stabilizers, foam boosters, fungicides, gellants, glosser, hair conditioner, hair set resins, hair sheen agents, hair waving agents, humectants, lubricants, moisture barrier agents, moisturizers, ointment bases, opacifier. plasticizer, polish, polymers, powders, propellant, protein, refatting agents, sequestrant, silicones, skin calming agents, skin cleansers, skin conditioners, skin healing, skin lightening agents, skin protectants, skin smooming agents, skin softening agents, skin soothing agents, stabilizers, sunscreen agents, surfactants, suspending agents, tanning accelerators, diickeners. vitamins, waxes, wetting agents, liquefiers. colors, flavors and/or fragrances
16. The composition of claim 1, wherein die cosmetic composition takes a form selected from me group consisting of lotions, creams, sticks, roll-on formulations, mousses, sprays, aerosols, pad-applied formulations and masks.
17. The composition of claim 1, wherein die viscosification occurs at a temperamre in die range of about 27 to 40┬░ C.
18. The composition of claim 1, wherein d e viscosification occurs at a temperamre in me range of about 30 to 37 ┬░C.
19. The composition of claim 1. wherein said composition is formulated as a product selected from me group consisting of baby products, baby shampoos, lotions, powders and creams: bath preparations, bad oils, tablets and salts, bubble baths, bad fragrances bath capsules; eye makeup preparations, eyebrow pencil, eyeliner, eye shadow, eye lotion, eye makeup remover, mascara; fragrance preparations, colognes, toilet waters, powders and sachets; noncoloring hair preparations, hair conditioner, hair spray, hair straighteners. permanent waves, rinses, shampoos, tonics, dressings and other grooming aids: color cosmetics: hair coloring preparations, hair dye, hair tints, hair color sprays, hair lighteners and hair bleaches; makeup preparations, face powders, foundations, leg and body paints, lipstick makeup bases, rouges and makeup fixatives; manicuring preparations, basecoats, undercoats, cuticle softeners, nail creams, nail extenders, nail polish and enamel, and remover; oral hygiene products, dentrifices, mouthwashes; personal cleanliness, bad soaps, detergents, deodorants, douches and feminine hygiene product; shaving preparations, aftershave lotion, beard softeners, men's talcum, shaving cream, shaving soap, preshave lotions; skin care preparations, skin cleansing preparations, skin antiseptics, depilatories, face and neck cleansers, body and hand cleansers, foot powders; moisturizers, night preparations, paste masks, skin fresheners; and suntan preparations, suntan creams, gels and lotions, and indoor tanning preparations.
20. The cosmetic composition of claim 1 or 2, wherein die poloxamer component is present in an amount in the range of about 0.01 to 20 wt% and the poly(acrylic acid component) is present in die amount of about 0.01 to 20 wt%.
21. The cosmetic composition of claim 1, wherein the polymer network comprises a plurality of poloxamers.
22. The cosmetic composition of claim 1, wherein die polymer network comprises a plurality of poloxamer components randomly bonded to a poly(acrylic acid) backbone.
23. The cosmetic composition of claim 1. wherein the reversibly viscosifying polymer composition comprises a plurality of poly(acrylic acid) components randomly bonded to a poloxamer component.
24. The cosmetic composition of claim 1, wherein d e aqueous-based medium is selected from d e group consisting of water, salt solutions and water wid water-miscible organic compound(s).
25. The cosmetic composition of claim 1, further comprising an additive selected to increase transition temperamre and increase viscosity of d e reversible viscosifying polymer network.
26. The cosmetic composition of claim 1, further comprising an additive selected to increase transition temperamre and decrease viscosity of die reversible viscosifying polymer network.
27. The cosmetic composition of claim 1, further comprising an additive selected to increase transition temperamre without affecting viscosity of die reversible viscosifying polymer network..
28. The cosmetic composition of claim 1, further comprising an additive selected to decrease transition temperature and increase viscosity of me reversible viscosifying polymer network.
29. The cosmetic composition of claim 1, further comprising an additive selected to decrease transition temperamre and decrease viscosity of the reversible viscosifying polymer network.
30. The cosmetic composition of claim 1, further comprising an additive selected to decrease transition temperamre wid out affecting viscosity of the reversible viscosifying polymer network.
31. The cosmetic composition of claim 1, further comprising an additive selected to increase viscosity without affecting transition temperamre of the reversible viscosifying polymer network.
32. The cosmetic composition of claim 1, further comprising an additive selected to decrease viscosity without affecting transition temperamre of the reversible viscosifying polymer network.
33. The cosmetic composition of claim 1 or 2, characterized in diat d e gel remains translucent to light before and after response to the environmental stimulus.
34. The cosmetic composition of claim 1, wherein die poly(acrylic acid) is branched.
35. Metiiod of making an cosmetic composition, comprising: dissolving a poloxamer capable of aggregation in response to a change in temperature in acrylic acid monomer; initiating polymerization of the monomer to form a poly(acrylic acid) randomly bonded to me poloxamer, so as to form a reversibly viscosifying polymer composition; mixing the reversibly gelling polymer compositions with a cosmetic agent which imparts a desired cosmetic effect to d e composition.
36. The metiiod of claim 36, wherein a polymerization initiator is selected to provide d e polymer network having a selected temperamre of viscosification.
37. The method of claim 36, wherein one or more poloxamers are added.
38. The cosmetic composition of claim 1, wherein the reversibly viscosifying polymer network is present in an amount in me range of 0.01 % 10% .
EP98918925A 1997-05-01 1998-05-01 Compositions for cosmetic applications Withdrawn EP0927019A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84688397A 1997-05-01 1997-05-01
US846883 1997-05-01
PCT/US1998/008931 WO1998048768A1 (en) 1997-05-01 1998-05-01 Compositions for cosmetic applications

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CA (1) CA2259464A1 (en)
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CA2259464A1 (en) 1998-11-05

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