EP0926955A4 - Conjugues utiles dans le traitement du cancer de la prostate - Google Patents

Conjugues utiles dans le traitement du cancer de la prostate

Info

Publication number
EP0926955A4
EP0926955A4 EP97942423A EP97942423A EP0926955A4 EP 0926955 A4 EP0926955 A4 EP 0926955A4 EP 97942423 A EP97942423 A EP 97942423A EP 97942423 A EP97942423 A EP 97942423A EP 0926955 A4 EP0926955 A4 EP 0926955A4
Authority
EP
European Patent Office
Prior art keywords
treatment
prostate cancer
conjugates useful
conjugates
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97942423A
Other languages
German (de)
English (en)
Other versions
EP0926955A1 (fr
Inventor
Dong-Mei Feng
Victor M Garsky
Raymond E Jones
Allen I Oliff
Jenny M Wai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9624170.8A external-priority patent/GB9624170D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0926955A1 publication Critical patent/EP0926955A1/fr
Publication of EP0926955A4 publication Critical patent/EP0926955A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP97942423A 1996-09-12 1997-09-10 Conjugues utiles dans le traitement du cancer de la prostate Withdrawn EP0926955A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2601596P 1996-09-12 1996-09-12
US26015P 1996-09-12
GB9624170 1996-11-19
GBGB9624170.8A GB9624170D0 (en) 1996-11-19 1996-11-19 Conjugates useful in the treatment of prostate cancer
PCT/US1997/016087 WO1998010651A1 (fr) 1996-09-12 1997-09-10 Conjugues utiles dans le traitement du cancer de la prostate

Publications (2)

Publication Number Publication Date
EP0926955A1 EP0926955A1 (fr) 1999-07-07
EP0926955A4 true EP0926955A4 (fr) 2003-05-07

Family

ID=26310443

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97942423A Withdrawn EP0926955A4 (fr) 1996-09-12 1997-09-10 Conjugues utiles dans le traitement du cancer de la prostate

Country Status (5)

Country Link
EP (1) EP0926955A4 (fr)
JP (1) JP2001501601A (fr)
AU (1) AU715632B2 (fr)
CA (1) CA2265476A1 (fr)
WO (1) WO1998010651A1 (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0100350A3 (en) * 1997-12-02 2001-09-28 Merck & Co Inc Conjugates useful in the treatment of prostate cancer, pharmaceutical compositions comprising thereof, process for their preparation and their use
US6174858B1 (en) 1998-11-17 2001-01-16 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
AU773420B2 (en) * 1998-12-11 2004-05-27 Medarex, Inc. Prodrug compounds and process for preparation thereof
US6649587B1 (en) * 1999-04-30 2003-11-18 Slil Biomedical Corporation Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
US6713454B1 (en) 1999-09-13 2004-03-30 Nobex Corporation Prodrugs of etoposide and etoposide analogs
CA2388700A1 (fr) * 1999-10-19 2001-04-26 Merck & Co., Inc. Processus de preparation de conjugues convenant pour le traitement du cancer de la prostate
GB9924759D0 (en) * 1999-10-19 1999-12-22 Merck Sharp & Dohme Process for preparing peptide intermediates
DE60020997T2 (de) * 1999-12-06 2006-05-24 Hopital Sainte-Justine, Montreal Verbindungen zur Behandlung von abnormaler Glomerulusfiltration, Ductus arteriosus apertus und Osteoporose
RU2002127425A (ru) 2000-03-15 2004-03-27 Бристоль-Мейерз Сквибб Фарма Компани (Us) Расщепляемые пептидазой целевые противоопухолевые лекарственные средства и их терапевтическое использование
DE60231868D1 (de) * 2001-04-24 2009-05-20 Purdue Research Foundation Folat-mimetika und deren folatrezeptorbindende konjugate
EP1504010B1 (fr) 2002-05-15 2009-03-25 Endocyte, Inc. Conjugues vitamine-mitomycine
AU2004210136C1 (en) 2003-01-27 2010-10-07 Endocyte, Inc. Vitamin receptor binding drug delivery conjugates
CN100372862C (zh) * 2003-11-05 2008-03-05 天津和美生物技术有限公司 具有抗癌活性的阿霉素衍生物及其制备方法和应用
EP1789391B1 (fr) 2004-07-23 2017-06-28 Endocyte, Inc. Groupes de liaison bivalents et conjugués de ceux-ci
US8044200B2 (en) 2005-03-16 2011-10-25 Endocyte, Inc. Synthesis and purification of pteroic acid and conjugates thereof
EP1900742A1 (fr) 2006-09-07 2008-03-19 AEterna Zentaris GmbH Conjugues des disorazoles et leurs dérives avec des molécules de liaison cellulaire, nouveaux dérives de disorazole, leurs modes de préparation et utilisation
US9555139B2 (en) 2007-03-14 2017-01-31 Endocyte, Inc. Binding ligand linked drug delivery conjugates of tubulysins
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
EP3569251A1 (fr) 2007-06-25 2019-11-20 Endocyte, Inc. Conjugués contenant des lieurs espaceurs hydrophiles
JP2011500835A (ja) 2007-10-25 2011-01-06 エンドサイト，インコーポレイテッド チューブリシン類および調製プロセス
WO2012123755A1 (fr) 2011-03-17 2012-09-20 The University Of Birmingham Immunothérapie redirigée
WO2013126797A1 (fr) 2012-02-24 2013-08-29 Purdue Research Foundation Ciblage du récepteur de la cholécystokinine de type b pour imagerie et thérapie
GB201203442D0 (en) 2012-02-28 2012-04-11 Univ Birmingham Immunotherapeutic molecules and uses
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
MX2015004757A (es) 2012-10-16 2015-07-17 Endocyte Inc Conjugados de suministro de farmacos que contienen aminoacidos no naturales y metodo para usarlos.
GB201402267D0 (en) * 2014-02-10 2014-03-26 Cambridge Entpr Ltd Antibacterial agents
EP3253419A1 (fr) 2015-02-02 2017-12-13 The University of Birmingham Complexes d'épitope de peptide de fragment de ciblage ayant une pluralité d'épitopes de lymphocyte t
CA3003482A1 (fr) 2015-11-19 2017-05-26 Revitope Limited Complementation de fragment d'anticorps fonctionnel pour un systeme a deux composants pour la destruction redirigee de cellules indesirables
CA3203072A1 (fr) 2020-12-22 2022-06-30 Andrea CASAZZA Composes comprenant une fraction tetrapeptidique
WO2022167664A1 (fr) 2021-02-07 2022-08-11 Cobiores Nv Composés comprenant une fraction tétrapeptidique

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0647450A1 (fr) * 1993-09-09 1995-04-12 BEHRINGWERKE Aktiengesellschaft Prodrogues améliorées pour activation médiée par enzyme
US5866679A (en) * 1994-06-28 1999-02-02 Merck & Co., Inc. Peptides
US5599686A (en) * 1994-06-28 1997-02-04 Merck & Co., Inc. Peptides
WO1997014416A1 (fr) * 1995-10-18 1997-04-24 Merck & Co., Inc. Conjugues utiles pour traiter l'adenome prostatique benin

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO9810651A1 *

Also Published As

Publication number Publication date
WO1998010651A1 (fr) 1998-03-19
AU4412397A (en) 1998-04-02
EP0926955A1 (fr) 1999-07-07
AU715632B2 (en) 2000-02-03
JP2001501601A (ja) 2001-02-06
CA2265476A1 (fr) 1998-03-19

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19990412

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 20030320

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61K 38/16 B

Ipc: 7A 61K 38/28 B

Ipc: 7A 61K 38/00 B

Ipc: 7A 01N 37/18 B

Ipc: 7A 61K 47/48 A

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN

18W Application withdrawn

Effective date: 20040121