EP0918456A1 - Composition desintegrante pour solides dispersibles - Google Patents

Composition desintegrante pour solides dispersibles

Info

Publication number
EP0918456A1
EP0918456A1 EP97934137A EP97934137A EP0918456A1 EP 0918456 A1 EP0918456 A1 EP 0918456A1 EP 97934137 A EP97934137 A EP 97934137A EP 97934137 A EP97934137 A EP 97934137A EP 0918456 A1 EP0918456 A1 EP 0918456A1
Authority
EP
European Patent Office
Prior art keywords
disintegrant
composition
super
cross linked
active agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP97934137A
Other languages
German (de)
English (en)
Inventor
Edward K. Sullivan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FMC Corp
Original Assignee
FMC Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FMC Corp filed Critical FMC Corp
Publication of EP0918456A1 publication Critical patent/EP0918456A1/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/12—Powders or granules
    • A01N25/14—Powders or granules wettable
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/0047—Detergents in the form of bars or tablets
    • C11D17/0065—Solid detergents containing builders
    • C11D17/0073—Tablets
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/02—Inorganic compounds ; Elemental compounds
    • C11D3/12—Water-insoluble compounds
    • C11D3/124—Silicon containing, e.g. silica, silex, quartz or glass beads
    • C11D3/1246—Silicates, e.g. diatomaceous earth
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/02—Inorganic compounds ; Elemental compounds
    • C11D3/12—Water-insoluble compounds
    • C11D3/124—Silicon containing, e.g. silica, silex, quartz or glass beads
    • C11D3/1246—Silicates, e.g. diatomaceous earth
    • C11D3/128—Aluminium silicates, e.g. zeolites

Definitions

  • the quantity super disintegrants necessary to rapidly disintegrate water-dispersible, solid dosage forms containing active agents may be substantially reduced, while at the same time maintaining or increasing the rate of disintegration, by substituting for a portion of the super disintegrant a co-disintegrant comprising a diatomaceous earth, a hydrophilic zeolite or a combination thereof to obtain a disintegration rate at least equal to, but preferably greater than that of the super disintegrant alone.
  • the co-disintegrant alone expressed as a weight percent of the total composition, may comprise from about 0.01 to 9.0 wt% . preferably about 0.1 to 2.7 wt%; and that the weight percent of the super disintegrant may comprise from about 0.045 to 8.0 wt% , preferably about 0.045 to 2.4 wt% .
  • Solid formulations are then prepared by mixing the blended components with the desired active agent plus, if desired, any ancillary ingredients, and the resulting mixture processed to include the desired forms such as tablets, pellets, beads, granules, balls, bars, disks and briquettes. Wettable powders, which do not require disintegrants, are excepted.
  • formulations may be produced from the blend of disintegrants and active agent by any of various known processes, including compression, roller compaction, wet granulation, extrusion, spheronization, and/or pan granulation.
  • dry granulation When tableting is the method selected for producing the solids, conventional dry granulation, wet granulation, direct compression, spheronization or spray drying may be used to prepare the blend for tableting.
  • the selection of method depends primarily on the active agent, the ability of the mixture of the disintegrants and active agent to flow freely in the tableting machine or extruder, and the cohesiveness of the ingredients. If the active agent can be admixed with the disintegrants to produce a free flowing, dense powder, the mixture can be directly compressed.
  • dry granulation a dry powdery blend of the components is compressed to form slugs if a tablet press is used. Alternatively, the dry blend is roller compacted into sheets. The slugs or sheets are then sieved to form densified granules for final tableting.
  • the super disintegrants which may be employed in this invention include such compounds as croscarmellose sodium (Ac- Di-Sol , FMC Corp., Philadelphia, PA.), crospovidone, sodium starch glycolate, and the like, or combinations thereof. See Handbook of Pharmaceutical Excipients, 2 nd Ed. , American Pharmaceutical Association, pp. 141 et seq. (1994). Of these, croscarmellose sodium is preferred. Chemically, it will be seen that each of these compounds represents examples of a wholly or partially cross-linked compound such as a cross-linked cellulose or carboxymethyl cellulose , a cross-linked polymer, and a cross-linked starch, respectively. Also, other alkali metal salts may be substituted for the sodium salts generally employed in these materials.
  • the co-disintegrant may also be a hydrophilic zeolite, preferably one with large open pore structure for channeling of water into a compressed tablet.
  • the co-disintegrant it should be noted, as shown by the examples, should have minimal disintegrant properties when employed alone.
  • this amount is not critical and may comprise as much as a major proportion by weight i.e. , in excess of 50 wt% of the total formulation thus, in practice, the choice of additive and amount are matters of routine consideration and trial for the skilled formulator. depending on the nature of the active agent.
  • lubricants facilitate the ejection of compacted forms from a die cavity. They may also reduce interparticle friction and prevent adhesion of materials to die and punch surfaces.
  • Typical lubricants are talc; long chain fatty acid esters or salts thereof such as stearic and palmitic acids, and magnesium or calcium stearate; and the like.
  • Glidants are limited to improvement of the flow properties of powders and granules, and include materials such as aerogenic silica, fumed silicon dioxide and silica hydrogel.
  • binders/fillers as dicalcium phosphate, Starch 1500 (sold by National Starch Co. , Bridgewater N.J.),
  • lactose, and microcrystalline cellulose (MCC) compositions for example.
  • MCC carboxymethyl cellulose
  • Lattice ® NT 200, which is microcrystalline cellulose alone.
  • Dispersants may be employed to further break down disintegrated aggregates to primary particle size, and include such materials as naphthalene condensates, ligno-sulfonates, poly aery lates, and phosphate esters.
  • the compounds are generally not applied full strength but are typically applied as formulations which may be applied as such or further diluted for application.
  • Typical formulations include, for example, dust and granule compositions containing the active ingredient in combination with one or more agriculturally acceptable adjuvants, carriers or diluents, preferably with a surface active agent, and optionally with other active ingredients.
  • the choice of formulation depends, of course, on the type of pest and environmental factors present at the particular locus of infestation.
  • the active ingredient of a typical agricultural formulation may, for example, comprise 0.01 percent to 1 percent up to about 90 or 95 percent by weight, preferably 1 percent up to 90 or 95 percent by weight, of the formulation.
  • Agriculturally acceptable carriers, diluents, adjuvants, surface active agents, and optionally other suitable active ingredients comprise the balance of the formulation.
  • a typical formulation may contain from 0.01 to 95 (preferably 1 to 95) percent by weight active ingredient, from 0 to 30 percent by weight surface active agent, and from 5 to 99.99 (preferably 5 to 99) percent by weight of an inert agriculturally acceptable carrier or diluent.
  • novel compositions of this invention provide not only a rapid rate of disintegration of the solids at significant cost savings for super disintegrants, but also, particularly in the pharmaceutical field, flexibility in dosage form design. Furthermore, chemically incompatible actives, such as tablets containing several different pesticides or combinations of herbicides and pesticides, can be separated in the solid dosage forms by forming multilayers using known techniques.
  • the disintegrant composition of this invention may, as stated above, be incorporated into conventional pharmaceutical preparations such as tablets (e.g. compressed tablets which may be coated, as with sugar paste).
  • the active agent may be present in admixture with a pharmacologically acceptable solid carrier; for example it may be a solid such as corn starch.
  • a pharmacologically acceptable solid carrier for example it may be a solid such as corn starch.
  • the dosage to be employed may be determined by routine experimentation well known in the art.
  • the active agent may be administered in combination with other drugs together with the novel disintegrant excipient.
  • Examples 1-7 show that synthetic, hydrous calcium silicate works effectively with croscarmellose sodium, sodium starch glycolate, and crospovidone three of the materials referred to above as 'super disintegrants', in increasing the disintegration rate.
  • Example 8 illustrates that comparable results may be obtained with natural diatomaceous earth. It will be noted that the combinations in the examples that included croscarmellose sodium were most effective.
  • examples 1 through 4 are representative of a vitamin formulation, such as niacinamide.
  • agricultural chemicals such as pesticides are frequently tableted to produce unit doses that need only to be placed in a specified volume of water prior to application.
  • Example 5 is intended to exemplify the use of this disintegrant combination in an agricultural pesticide formulation, since ferrous sulfate is listed as a selective herbicide to control broadleaf weeds.
  • Industrial uses would include, for example, detergents such as are shown in examples 6 and 7, or granular fertilizers, which could be formulated routinely by those skilled in the art.
  • Example 9 illustrates the use of a hydrophilic zeolite as a co-disintegrant.
  • the additives include binders, such as microcrystalline cellulose, starch and/or lactose, lubricants such as magnesium stearate and/or stearic acid, and fillers such as dicalcium phosphate.
  • binders such as microcrystalline cellulose, starch and/or lactose
  • lubricants such as magnesium stearate and/or stearic acid
  • fillers such as dicalcium phosphate.
  • Example 2 By the method of Example 1 , 50 grams (25 wt %) of niacinamide, 140 grams (70 wt %) of dicalcium phosphate, 1.0 gram (0.5 wt %) of sodium starch glycolate, 4.0 grams (2.0 wt %) of synthetic diatomaceous silica, 4.0 grams (2.0 wt %) of stearic acid, and 1.0 gram (0.5 wt %) of magnesium stearate were combined and compressed into tablets weighing 775 mg. The properties of these tablets were measured as described in Example 1. Table 2 shows the formulations corresponding to those in Table 1 with the sodium starch glycolate replacing croscarmellose sodium.
  • Example 2a is a formulation of the invention, and Examples 2b-2d are comparative examples.
  • Example 1 By the method of Example 1, 50 grams (25 wt %) of niacinamide, 140 grams (70 wt %) of dicalcium phosphate, 1.0 gram (0.5 wt %) of crospovidone, 4.0 grams (2.0 wt %) of synthetic diatomaceous silica, 4.0 grams (2.0 wt %) of stearic acid, and 1.0 gram (0.5 wt %) of magnesium stearate were combined and compressed into tablets weighing 775 mg. The properties of these tablets were measured as described in Example 1. Table 3 shows the formulations corresponding to those in Table 1 with the crospovidone replacing croscarmellose sodium.
  • Example 3a is a formulation of the invention, and Examples 3b-3d are comparative examples.
  • the blended material was then compressed into tablets weighing 1750 mg on a Stokes single station F press fitted with 15.9 mm (0.625 inch) flat- faced, beveled-edge tooling.
  • the compression forces were varied to produce tablets having tablet hardness of 4, 8, and 12 Kp, respectively.
  • Twenty- four hours after compression hardness was measured for six tablets at each compression force.
  • disintegration tests were performed using USP 701 XXII apparatus. These tests were done in 37 °C distilled water. The average disintegration time for six tablets at each hardness was determined.
  • a control formulation was prepared in which croscarmellose sodium was the only disintegrant incorporated.
  • Example 4a is a formulation of the invention
  • Example 4b is the comparative example.
  • the granule sizes ranged from 425-1180 microns. These granules were described as being very durable.
  • the disintegration time of the granules was determined by the method of USP 701 XXII using a 100 mesh screen. A 5 gram sample of the granules was placed in the basket which was immersed in 37°C distilled water. The disintegration time of this sample was 1.1 minutes. This description is specific to Example 5a, but the same procedure was followed for Examples 5b-5d. Table 5 shows the formulations corresponding to those in Table 1 , i.e. Example 5a is an example of the invention, and Examples 5b-5d are comparative examples.
  • Alconox Detergent powder Alconox, Inc. , New York, NY 10003
  • Alconox Detergent powder Alconox, Inc. , New York, NY 10003
  • an alkaline detergent comprising a blend of sulfates, phosphates, and carbonates, and used, e.g., as a laboratory equipment cleaner, 60 grams (30.0 wt %) of Lattice " NT200 (FMC Corporation, Philadelphia, PA 19103), 3.0 grams (1.5 wt %) of croscarmellose sodium (Ac-Di-Sof sold by FMC Corporation, Philadelphia, PA 19103), 3.0 grams (1.5 wt %) of synthetic diatomaceous silica, and 0.8 gram (0.4 wt %) of magnesium stearate.
  • control formulations were prepared in which no excipient was added; one in which only Lattice NT200 was included; one in which only synthetic diatomaceous silica was in combination with Lattice NT200; and one in which croscarmellose sodium was in combination with Lattice NT200.
  • the amount of Alconox detergent powder was adjusted to make up for the added excipients.
  • the comparative examples are numbered 6a, 6b, 6c, and 6g, respectively.
  • Table 6 provides the composition of all formulations and a summary of hardness and disintegration times for the tablets prepared from them.
  • Examples 6d, 6e, and 6f are all examples of the invention; however, Example 6e is the specific formulation of the invention that is described in this example. All examples were prepared by the identical method, adjusting the amounts of each component appropriately.
  • Example 6 By the method of Example 6, 136.2 grams (68.1 wt %) of Alcono Detergent powder (Alconox, Inc., New York, NY 10003), 60 grams (30.0 wt %) of Lattice TM NT200, 1.5 grams (0.75 wt %) of croscarmellose sodium (Ac-Di-Sof). 1.5 grams (0.75 wt %) of synthetic diatomaceous silica, and 0.8 gram (0.4 wt %) of magnesium stearate were mixed in a twin cone blender. Tablets weighing approximately 3.0 grams were compressed in the same manner as described in Example 6. The same testing procedures were also used. This specific example is identified as 7a, and the results for this example as well as two comparative examples, 7b and 7c, are shown in Table 7.
  • Example 8 By the method of Example 6, 133.2 grams (66.6 wt %) of Alconox
  • Detergent powder 60 grams (30.0 wt %) of Lattice TM NT200, 3.0 grams (1.5 wt %) of croscarmellose sodium (Ac-Di-Sol ), 3.0 grams (1.5 wt %) of natural diatomaceous silica, and 0.8 gram (0.4 wt %) of magnesium stearate were mixed in a twin cone blender. Tablets weighing approximately 3.0 grams were compressed in the same manner as described in Example 6. The same testing procedures were also used. This specific example of the invention is identified as 8a. The results for this example as well as comparative examples 6g, 8b, and 8c are shown in Table 8.
  • Example 9a in Table 9.
  • control formulations were prepared in which no excipient was added; one in which only synthetic diatomaceous silica was added; one in which only zeolite was added.
  • Table 9 provides the composition of all formulations and a summary of hardness and disintegration times for the tablets prepared from them. Examples 9a and 9b are examples of the invention. Example 9c is included in Table 9 for comparison.
  • Example 6 it will be seen that in Examples 6(d), 6(e), and 6(f). where the disintegrants are combined in accordance with this invention, (where 6(e) represents the specific formulation of the invention that is described in Example 6) the disintegration rate is superior to that of any of the control examples; (a), (b). (f), and (g). This is especially evident in Examples 6(e) and (c), where increased amounts of diatomaceous silica are substituted for the super disintegrant. In Example 7 this improvement is also demonstrated, especially in view of one of the disintegration rates in Example 7(a), of the invention, which is about half that of the control examples. In Example 8a, it will be seen that the combination of super disintegrant with natural diatomaceous earth is effective over diatomaceous silica alone.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

Composition utile en tant qu'excipient pour augmenter le taux de désintégration de formulations solides d'agents actifs dans des compositions pharmaceutiques, agricoles, industrielles et autres. Ledit excipient est une composition qui comporte un super-désintégrant et un co-désintégrant.
EP97934137A 1996-07-23 1997-07-15 Composition desintegrante pour solides dispersibles Pending EP0918456A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US889185 1986-07-25
US797517 1991-11-22
US79751796A 1996-07-23 1996-07-23
US88918597A 1997-07-07 1997-07-07
PCT/US1997/012183 WO1998003064A1 (fr) 1996-07-23 1997-07-15 Composition desintegrante pour solides dispersibles

Publications (1)

Publication Number Publication Date
EP0918456A1 true EP0918456A1 (fr) 1999-06-02

Family

ID=27121887

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97934137A Pending EP0918456A1 (fr) 1996-07-23 1997-07-15 Composition desintegrante pour solides dispersibles

Country Status (4)

Country Link
EP (1) EP0918456A1 (fr)
AU (1) AU3726597A (fr)
CA (1) CA2258917A1 (fr)
WO (1) WO1998003064A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9711829D0 (en) 1997-06-06 1997-08-06 Unilever Plc Detergent compositions
ZA984570B (en) 1997-06-06 1999-11-29 Unilever Plc Cleaning compositions.
CA2217238C (fr) * 1997-10-24 2005-09-20 Louis Cartilier Cellulose reticulee employee comme excipient de comprimes
US6232351B1 (en) * 1998-05-22 2001-05-15 Amway Corporation Co-processed botanical plant composition
DE19828577A1 (de) * 1998-06-26 1999-12-30 Henkel Kgaa Verfahren zur Herstellung von Wasch- und Reinigungsmittelformkörpern
DE19855203A1 (de) * 1998-11-30 2000-05-31 Kurt Heinz Bauer Coprozessiertes Polysaccharidprodukt
DE19910818A1 (de) * 1999-03-11 2000-09-14 Henkel Kgaa Wasch- und Reinigungsmittelformkörper mit Tensid-Builderkombination
ES2306492T3 (es) * 1999-07-19 2008-11-01 Fit Gmbh Producto polisacarido coelaborado con polivinilpirrolidona reticulada.
DK1070740T3 (da) * 1999-07-19 2008-05-13 Fit Gmbh Co-forarbejdet polysaccharidprodukt med uoplöseligt carboxymethylcellulose
GB9918782D0 (en) * 1999-08-10 1999-10-13 Crosfield Joseph & Sons Cleaning compositions
WO2001012767A1 (fr) * 1999-08-12 2001-02-22 The Procter & Gamble Company Composant de desintegration et composition detergente contenant ce composant
WO2003030868A1 (fr) * 2001-10-09 2003-04-17 Bristol-Myers Squibb Company Formes posologiques orales obtenues par fusion-eclair
CA2311734C (fr) 2000-04-12 2011-03-08 Bristol-Myers Squibb Company Forme pharmaceutique orale a dissolution ultra-rapide
CA2462886C (fr) * 2001-10-09 2013-07-30 Bristol-Myers Squibb Company Formes posologiques orales obtenues par fusion-eclair
HU1000278D0 (en) * 2010-05-28 2010-07-28 Egis Gyogyszergyar Nyilvanosan Novel pharmaceutical use uf silicic acid
WO2022258453A1 (fr) * 2021-06-07 2022-12-15 Unilever Ip Holdings B.V. Composition de pastille
WO2024052103A1 (fr) * 2022-09-08 2024-03-14 Unilever Ip Holdings B.V. Composition de lessive

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4780315A (en) * 1985-11-25 1988-10-25 Eastman Kodak Company Rumen-stable pellets
US5074902A (en) * 1990-07-30 1991-12-24 Connick Jr William J Granular products containing fungi encapsulated in a wheat gluten matrix for biological control of weeds
US5314852A (en) * 1992-11-13 1994-05-24 Fred Klatte Chemically impregnated zeolite and method for chemically impregnating and coating zeolite

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9803064A1 *

Also Published As

Publication number Publication date
WO1998003064A1 (fr) 1998-01-29
AU3726597A (en) 1998-02-10
CA2258917A1 (fr) 1998-01-29

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