Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
  • A61K36/18—Magnoliophyta (angiosperms)
  • A61K36/185—Magnoliopsida (dicotyledons)
  • A61K36/42—Cucurbitaceae (Cucumber family)
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
  • A61K36/18—Magnoliophyta (angiosperms)
  • A61K36/185—Magnoliopsida (dicotyledons)
  • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
  • A61K36/18—Magnoliophyta (angiosperms)
  • A61K36/185—Magnoliopsida (dicotyledons)
  • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
  • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
  • A61K8/9783—Angiosperms [Magnoliophyta]
  • A61K8/9789—Magnoliopsida [dicotyledons]
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
  • A61Q19/08—Anti-ageing preparations
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q5/00—Preparations for care of the hair
  • A61Q5/02—Preparations for cleaning the hair

Definitions

• the present invention relates to compositions, in particular cosmetic and / or pharmaceutical and / or dermatological, intended in particular to promote skin care. It also relates to the process for manufacturing such compositions.
• the cosmetic compositions proposed are most often based on synthetic chemicals which are therefore unnatural, the manufacture of which is moreover complex and costly.
• the treatment of the skin is not only aesthetic.
• acne and the damage it causes come from the sebaceous glands associated with the hair follicles, especially on the face, back, chest. These glands contain cells which secrete a mixture containing in particular triglycerides, fatty acids called "sebum". In acne, sebum secretions increase, the ducts of the sebaceous glands thicken and produce blackheads or blackheads, and inflammation around the sebaceous glands appears.
• the main known treatments for acne either are not really effective (various gels and ointments), or have serious drawbacks whether antibiotics (absorption of antibiotics for a long time by oral or local route, the latter mode being risky to create resistant bacteria antibiotics) or retinoids (compounds close to vitamin A which are only administered in a hospital environment and have an impact on the liver).
• Eczema is an inflammatory condition of the skin characterized by groups of vesicular lesions of varying sizes. Known treatments are generally based on steroids and / or antibiotics, which are drugs which have disadvantages, sometimes serious. Psoriasis and parapsoriasis are pathological pictures that manifest themselves in any part of the surface of the body and can even completely cover it. The severity of the lesions depends on both the extent and the depth to which the psoriatic process affects the dermal layers. An important point of the pathology of psoriasis is that the regeneration of the epidermis is much faster in the case of psoriasis than for normal skin (3-4 days instead of 27 days).
• the invention aims to overcome the above drawbacks by proposing compositions in particular cosmetic and / or pharmaceutical based on usual food plants.
• the invention provides a composition characterized in that it comprises a mixture, called base mixture, consisting of the liquid extracted from a mixture M of tomatoes and apples, once the spontaneous reaction initiated by the mixture of two plants in crushed form.
• the mixture M also comprises a gelling or thickening agent and / or an emollient agent.
• this gelling or thickening agent will consist of peaches or persimmons and this emollient agent will consist of cucumbers.
• the mixture M does not include a gelling agent or an emollient, it comprises apples and tomatoes of approximately equal weight.
• the mixture M comprises peaches or persimmons as a gelling or thickening agent and cucumbers as an emollient agent
• it comprises between 30 and 35% of peaches or persimmons, between 30 and 35% of apples and approximately 30% of tomatoes, in percentage by weight relative to the weight of the final mixture (M).
• it comprises between 25 and 30% of peaches or persimmons, between 20 and 25% of apples, between 20 and 25% of tomatoes and between 25 and 30% of cucumbers, as a percentage by weight relative to the weight of the final M mixture.
• a softening or lysing agent is added to said base mixture.
• This tenderizing or lysing agent will be more particularly chosen from the group consisting of papaya, papain, chemopapain, trypsin, pineapple, fig latex or pepsin.
• the preferred tenderizing or lysing agent of the invention is papaya. In this case, approximately one third by weight of papaya and approximately two thirds by weight of said base mixture are added.
• compositions according to the invention may also contain an acidifying agent.
• a preferred acidifying agent is lemon juice.
• an irritant is added to said base mixture.
• a preferred irritant is cooking water from red or green peppers.
• a mixture which is at the same time protective of the skin is added to said base mixture, since it comprises anti-free radical substances such as vitamin C, vitamin E, beta-carotene, and nourish the skin, because it contains vitamins A, B, PP, amino acids, carbohydrates, sterols, purines, fatty acids, calcium and trace elements such as iron, copper, manganese , sulfur, phosphorus, diode and optionally phospholipids.
• the preferred nourishing or nourishing and protective medium is composed of cabbage juice or cooking water, in water preferably slightly mineralized, cabbage, preferably green cabbage, possibly mixed with juice from the cooking water of other plants.
• the nourishing medium is composed of cooking water, preferably in slightly mineralized water, either of green cabbage or of a mixture in equal proportions by weight of green cabbage and green salads with thick leaves such than lettuce.
• compositions of the invention can be used for the manufacture of a cosmetic and / or pharmaceutical composition intended to promote skin care.
• the invention provides a body lotion for regenerating and firming the skin, which is characterized by adding to said base mixture or to the base mixture added with a lysing or tenderizing agent, preferably papaya, nourishing medium containing vitamins A, B, C, D, E, PP, amino acids, calcium and trace elements such as iron, copper, manganese, sulfur, phosphorus, iodine etc. and optionally an acidifying agent, preferably lemon juice.
• a lysing or tenderizing agent preferably papaya
• nourishing medium containing vitamins A, B, C, D, E, PP, amino acids, calcium and trace elements such as iron, copper, manganese, sulfur, phosphorus, iodine etc.
• an acidifying agent preferably lemon juice.
• a particularly preferred body lotion is composed of one volume of said base mixture or of said base mixture added with papaya and three volumes of said cooking water, and optionally, lemon juice.
• Another object of the invention is a cosmetic composition for the regeneration and firming of the skin, the prevention of wrinkles and the attenuation of existing wrinkles, characterized in that it contains said base mixture or said base mixture added with a softening or lysing agent, preferably papaya, and a thickener and / or a preservative and / or water and / or fats and / or hydrating fats and / or water / fat emulsifiers, cosmetically acceptable for application in cream or mask.
• Another object of the invention is a lotion improving tolerance to the sun, when applied before exposure to the sun, and alleviating the pain caused by excessive exposure to the sun, when applied after exposure to the sun, characterized in that adding to the so-called basic mixture or to the so-called basic mixture added a softening or lysing agent, preferably papaya, an agent containing vitamin A compounds such as vitamin A and pro-vitamin A, a nourishing medium containing vitamins A, B, C, D, E, PP, calcium and trace elements and optionally fat and / or water / fat emulsifiers.
• a softening or lysing agent preferably papaya
• an agent containing vitamin A compounds such as vitamin A and pro-vitamin A
• a nourishing medium containing vitamins A, B, C, D, E, PP, calcium and trace elements and optionally fat and / or water / fat emulsifiers.
• the agent containing compounds of vitamin A is composed of carrot juice.
• a more preferred lotion is a lotion in which said nourishing medium is composed of cooking water, preferably in weakly mineralized water, of a mixture in equal proportions by weight, of beetroot, green cabbage and d spinach and said fat is grape seed oil.
• a lotion improving tolerance to the sun and alleviating pain in the event of excessive exposure to the sun is made up, in equal proportions by volume of said mixture.
• basic mixture B with or without the addition of a lysing agent and an acidifying agent and said cooking water, mixture (B) to which 20% by volume, relative to the volume of mixture (B), is added.
• Yet another object of the invention is a shampoo for normal scalp, characterized in that it consists of said base mixture or of said base mixture added with a lysing or tenderizing agent, preferably papaya, and optionally an acidifying agent such as lemon juice and a sufficient amount of shampoo to obtain a washing action.
• a lysing or tenderizing agent preferably papaya
• an acidifying agent such as lemon juice
• This shampoo can also be supplemented with a nourishing medium containing vitamins A, B, C, D, E, PP, amino acids, calcium and optionally phospholipids and trace elements.
• a preferred nourishing medium is composed of cooking water, preferably in slightly mineralized water, of one part by weight of green cabbage and two parts by weight of spinach, and three volumes of said cooking water to a volume of said shampoo.
• a pharmaceutical and / or cosmetic composition called dermatological composition No 2 for treating mild psoriasis, acne and seborrhea, characterized in that the so-called basic mixture, added, is added or not a softening or lysing agent, preferably papaya, and an acidifying agent, preferably lemon juice, an irritant and possibly a nourishing medium containing vitamins A, B, C, D, E , PP, amino acids, calcium and possibly phospholipids and trace elements.
• a preferred dermatological composition No2 of the invention is characterized in that said irritant agent consists of green or red peppers and in that said nourishing medium consists of cooking water, in water preferably weakly mineralized, either green cabbage or a mixture M of green cabbage and thick leafy green salads, preferably lettuce, and raw beets, and adding three parts by volume of the said cooking water to a volume of said base mixture with or without the addition of a lysing agent and an acidifying agent.
• said irritant agent is composed of the cooking water of three green or red peppers with a length of about 4 to 20 cm medium and said nourishing agent or said cooking water is obtained by cooking in one liter of water, preferably weakly mineralized, either from green cabbage only or about 80g of green cabbage, 50g of green salads with thick leaves and 100g of beets.
• the invention also provides a pharmaceutical and / or cosmetic composition for the treatment in particular of acne, seborrhea, eczema and psoriasis, characterized in that a mixture (A) of said base mixture is added.
• a lysing agent preferably papaya
• an acidifying agent preferably lemon
• the dermatological composition No2 in combination with a pharmaceutically and / or cosmetically acceptable excipient such as a preservative or a gelling agent and / or thickener for application as a cream or lotion.
• composition is particularly characterized in that the mixture (A) consists of a third by volume of said base mixture, whether or not added with a lysing or softening agent, preferably papaya, with an acidifying agent, preferably lemon juice and two thirds by volume of the dermatological composition No2.
• a lysing or softening agent preferably papaya
• an acidifying agent preferably lemon juice
• a particular pharmaceutical composition for the treatment of psoriasis is a composition in which the mixture A consists of one third by volume of the base mixture supplemented with papaya and two thirds by volume of the dermatological composition No2.
• composition A consists of one sixth by volume of the base mixture with or without added lysing or softening agent, preferably papaya and an agent acidifier, preferably lemon juice and five sixths by volume of the dermatological composition No2.
• a pharmaceutical and / or cosmetic composition for the treatment of acne is a composition in which the mixture (A) consists of two thirds by volume of said base mixture, whether or not added with a lysing or softening agent, preferably papaya, and an acidifying agent, preferably lemon juice, is one third by volume of the dermatological composition No2.
• a lysing or softening agent preferably papaya
• an acidifying agent preferably lemon juice
• composition A for the treatment of seborrhea and / or psoriasis of the scalp, is a composition consisting of mixture A in combination with a sufficient amount of shampoo to obtain a washing action.
• said mixture A consists of one third by volume of the base mixture supplemented with papaya and two thirds by volume of the dermatological composition No2.
• a subject of the invention is also the process for manufacturing such compositions, in particular pharmaceutical and / or cosmetic and / or dermatological, the process being of the type consisting in grinding and mixing together the starting ingredients, to allow them to react chemically then to filter the ground mixture thus obtained to obtain on the one hand a solid and on the other hand a liquid, characterized in that the starting ingredients include apples, tomatoes and , optionally a lysing agent and an emollient agent.
• the present invention is based first of all on the surprising discovery that: a) the mixture of approximately equal weights of apples, preferably green or yellow crushed and raw tomatoes, also crushed, causes a spontaneous chemical reaction which lasts approximately 24 hours and which results in a release of heat as well as surprising properties for the mixture after the end of the chemical reaction b) the juice extracted from this mixture unexpectedly exhibits stimulating and regenerating activity of the skin.
• This activity manifests itself in particular in the following form: a few minutes after the coating of the face of a subject with the juice extracted from a mixture of suitable proportions of tomatoes, apples, a strong sensation of heat is felt, redness appears and grows; after about twenty minutes the redness and heat gradually decrease and then stop to give way to a feeling of freshness and well-being. By then rinsing the face with water, the cells dead skin is eliminated.
• the intensity of the phenomenon and its duration depend on the type of skin and the number of treatments undergone by the subject.
• this juice being particularly active, a gelling and / or thickening agent and an emollient agent can be added to the mixture of tomatoes and apples.
• the preferred gelling agent here is peach or persimmon, both fruits rich in pectin, the gelling properties of which are known, but of course, any other gelling and / or thickening agent which will appear to those skilled in the art as suitable may also be used here, such as the gels usually used in cosmetics or hyaluronic acid, also used in cosmetics.
• the preferred emollient here is cucumber, but of course, any other emollient that will be apparent to those of skill in the art can also be used here.
• This basic mixture can be supplemented with other plants or substances to have either less strong effects than those of the basic mixture and make it possible in particular to produce toning lotions and shampoos, or on the contrary stronger effects, in particular for being able achieve the effect described above in depth, that is to say in the dermis and no longer only on the surface of the skin.
• This deep action can be obtained by adding ground papayas to the base mixture.
• the papaya plays the role of a tenderizing agent of the epidermis and the dermis.
• vegetable products known for their digestive and tenderizing properties of meat such as pineapple, latex of the fig tree, to replace papaya or, chemically pure or refined products contained in papaya, l pineapple, the latex of the fig tree such as papain, chemopapain, bromelain, pepsin or trypsin.
• the ratios of the weights of all the plants entering into the different compositions described here is not critical for observing the effect, but for having a maximum intensity of this effect and not depending on the compositions of each plant, which vary appreciably from one batch to another like any natural product, the following proportions in percentage by weight relative to the weight of the final mixture to be obtained are particularly preferred: a) in the case of a base mixture not incorporating gelling and / or thickening agent or emollient, we will take equivalent weights of apples and tomatoes b) in the case of a base mixture incorporating a gelling agent based on peach or persimmon, we will take between 35 and 40 % of peaches or persimmons, between 30 and 35% of apples and around 30% of tomatoes, in percentage by weight relative to the weight of the final mixture to be obtained c) in the case where one wants to obtain a softening and emollient action , in particular with cucumber, we will take between 25 and 30% of peaches or persimmons, between 20 and
• the mixture thus obtained is then chopped and mixed for example in a food mixer. This mixture is then filtered through a filter whose mesh diameter is 0.5 mm or less to extract the liquid.
• the most active part is the liquid, it is possible to not filter the crushed mixture and to use it as it is as a basic mixture as defined here.
• This basic mixture can be used at the rate of one application every five days at the most, with an effect of desquamation, firming and regeneration of the skin, prevention of wrinkles and reduction of existing wrinkles or used to prepare other compositions.
• an acidifying agent can be added to this basic mixture.
• a preferred acidifying agent is lemon juice due to its known actions on the skin: skin discoloration action, cleansing of oily skin, firming of the skin and nails.
• any other acidifying agent known to those skilled in the art will also be suitable.
• a nourishing medium containing vitamins A, B, C, D, E, PP, calcium, amino acids, possibly phospho lipids and trace elements such as iron, copper, manganese, sulfur, phosphorus, etc.
• a preferred nourishing medium consists of the cooking water of certain vegetables.
• Example 1 Body lotion to firm the skin and remove dead cells.
• this body lotion mix one volume of the base mixture with or without lemon juice mixed with three volumes of the cooking water, a mixture of green cabbage and thick leafy green salads, preferably lettuces.
• a mixture of green cabbage and thick leafy green salads preferably lettuces.
• a preservative and / or a gelling and / or thickening agent can be added to this body lotion.
• EXAMPLE 2 Cosmetic composition for the regeneration and firming of the skin, the prevention of wrinkles and the attenuation of existing wrinkles.
• the base mixture whether or not containing papaya and / or lemon juice, is mixed with a thickener and / or a preservative and / or water and / or fats and / or hydrating fats, cosmetically acceptable for an application in cream or mask.
• cosmetic creams of the type sold commercially can be used as an excipient.
• Example 3 Lotion allowing to increase the tolerance to the sun when it is applied before the exposure to the sun and to alleviate and relieve the pain following an excessive exposure to the sun.
• a volume of said base mixture is mixed with a volume of the cooking water, in slightly mineralized water, of a mixture in equal proportions by weight of beets , green cabbage and spinach.
• the cooking water is obtained by boiling for 20 min, in one liter of water weakly mineralized, 100g of raw beets, 100g of green cabbage and 100g of spinach.
• fat and water / fat emulsifying agents, hydrating agents or even a moisturizing cream of the type sold commercially can be added to obtain a complementary hydration effect at the same time.
• Carrot juice gives a coloring of the skin but it is not its only effect. It acts in synergy with the basic mixture and as an agent containing vitamin A compounds such as vitamin A and pro-vitamin A. Thus, any other agent providing these compounds can be used here.
• the preceding lotion has the disadvantage of risking staining clothing.
• An alternative composition which does not have this drawback consists in replacing the carrot juice by green cabbage juice, which is almost as rich as carrot juice in beta-carotene.
• Example 4 Shampoo for normal scalp.
• the cooking water is obtained by boiling for 20 minutes in a liter of weakly mineralized water, 100g of green cabbage and 200g of spinach. Three volumes of this cooking water are mixed with one volume of the base mixture. We add possibly 100 to 140 drops of lemon juice to about a liter of the previous mixture.
• Normal scalp is understood here to mean a scalp which does not have excess seborrhea or dermatological conditions.
• Example 5 Cosmetic and / or pharmaceutical composition called dermatological composition No 1 for attenuating and / or eliminating the states of seborrhea and mild acne.
• the papaya is cut into pieces with the skin and the flesh, not taking the seeds.
• Example 6 Cosmetic and / or pharmaceutical composition called dermatological composition No 2 for attenuating and / or eliminating the states of psoriasis, acne and mild seborrhea.
• Three volumes of the cooking water are mixed with three green or red peppers between 4 cm and 20 cm long, cut into a mixture of green cabbage, green salads, thick leaves, preferably lettuce, raw beets, and green or red peppers with a volume of dermatological composition No 1.
• the aforementioned cooking water will be obtained by boiling in one liter of weakly mineralized water, for 25 minutes, three green or red peppers with a length of between approximately 4 cm and approximately 20 cm cut into pieces and 80 g cabbage greens, 50g of green leaves with thick leaves, 100g of raw beets.
• the peppers here have the function of an irritant.
• any irritant that will appear to those skilled in the art may be used.
• any substance providing capsaicin or a member of the capsaicinoid family may be used.
• a composition is thus obtained which, unexpectedly, has a selective scaling effect limited to the skin horny or affected by conditions such as psoriasis, acne and seborrhea.
• compositions are obtained which, unexpectedly, make it possible to treat disorders or affections of the skin such as acne, seborrhea, eczema and psoriasis.
• compositions No 1 and No 2 can either be made in advance in a fixed manner, or on the contrary advantageously, evolve over time to first favor one type of effect and then the other, or come from alternate applications of two compositions.
• Example 7 Pharmaceutical composition for the treatment of psoriasis.
• a particularly preferred composition for the treatment of psoriasis consists of a mixture of one third by volume of the dermatological composition No 1 and two thirds by volume of the dermatological composition
• this mixture is applied three days a week twice an hour and a half to the affected parts.
• this composition may be added with a thickener and / or a preservative.
• Example 8 Pharmaceutical composition for the treatment of eczema.
• a preferred composition for treating eczema consists of a mixture of one sixth by volume of the dermatological composition No 1 with five sixths by volume of the dermatological composition No 2.
• this composition is applied three days a week twice an hour and a half to the affected parts.
• this composition may be mixed with an excipient such as a thickener, a preservative, etc. to improve patient comfort and facilitate application as a cream or mask.
• an excipient such as a thickener, a preservative, etc.
• Example 9 Composition for the treatment of acne.
• a preferred mixture for treating acne consists of two thirds by volume of dermatological composition No 1 and one third by volume of dermatological composition No 2, whether or not containing excipients already mentioned
• this composition is applied three days a week twice an hour and a half to the affected parts.
• Example 10 Pharmaceutical and / or cosmetic composition for the treatment of seborrhea and / or psoriasis of the scalp.
• This composition consists of a mixture of one third by volume of dermatological composition No 1 and two thirds by volume of dermatological composition No 2 to which sufficient shampoo has been added to achieve a washing action.
• This composition is particularly interesting because it provides an easy and simple to use scalp treatment since it consists of simply washing the hair on average three times a week.
• the cosmetic and / or pharmaceutical, especially dermatological, compositions according to the present invention can be prepared in forms suitable for various modes of administration.
• they may be in a form intended for surface administration on the skin or the scalp, such as a cream, milk, gel or lotion in order to stimulate and regenerate or treat the skin.
• a non-negligible advantage of the invention is to provide pharmaceutical and / or cosmetic compositions which keep for a sufficiently long period (approximately 18 months at ambient temperature and light). This limits most storage and warehousing problems, without having to carry out the isolation of any active substance, these isolation methods are generally long and expensive.
• compositions containing the cooking water of certain particular vegetables have been described, it is understood that any other nourishing medium containing vitamins A, B, C, D, E, PP, calcium, amino acids and possibly phospholipids and trace elements may be used in an equivalent manner. Even more, certain compositions of the invention may be used in the form of food compositions, to obtain a systemic effect.

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• 1997
  • 1997-02-25 FR FR9702196A patent/FR2759904B1/fr not_active Expired - Fee Related
• 1998
  • 1998-02-24 WO PCT/FR1998/000362 patent/WO1998037864A1/fr active Application Filing
  • 1998-02-24 US US09/171,670 patent/US6780444B1/en not_active Expired - Fee Related
  • 1998-02-24 CA CA002252633A patent/CA2252633A1/fr not_active Abandoned
  • 1998-02-24 EP EP98910823A patent/EP0917456A1/de not_active Withdrawn
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