EP0873726B1 - Besamungsrohr mit einem aus einer mikroporösen Vollfaser hergestellten Stopfen - Google Patents

Besamungsrohr mit einem aus einer mikroporösen Vollfaser hergestellten Stopfen Download PDF

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Publication number
EP0873726B1
EP0873726B1 EP98400900A EP98400900A EP0873726B1 EP 0873726 B1 EP0873726 B1 EP 0873726B1 EP 98400900 A EP98400900 A EP 98400900A EP 98400900 A EP98400900 A EP 98400900A EP 0873726 B1 EP0873726 B1 EP 0873726B1
Authority
EP
European Patent Office
Prior art keywords
straw
stopper
microporous
range
resins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP98400900A
Other languages
English (en)
French (fr)
Other versions
EP0873726A1 (de
Inventor
Jean-Gérard Saint-Ramon
Gustavo Decuadro-Hansen
Christian Beau
Claude Dassier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IMV Technologies SA
Original Assignee
IMV Technologies SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IMV Technologies SA filed Critical IMV Technologies SA
Publication of EP0873726A1 publication Critical patent/EP0873726A1/de
Application granted granted Critical
Publication of EP0873726B1 publication Critical patent/EP0873726B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A61D19/02—Instruments or methods for reproduction or fertilisation for artificial insemination
    • A61D19/022—Containers for animal semen, e.g. pouches or vials ; Methods or apparatus for treating or handling animal semen containers, e.g. filling or closing
    • A61D19/024—Tube-like containers, e.g. straws

Definitions

  • the present invention relates to a straw for the preservation of small quantities of substances, in particular biological substances, in particular biological fluids.
  • An object of the invention is to provide a straw comprising a means shutter which, while being liquid tight and gas permeable, does not absorb no amount of liquid.
  • the present invention responds to such an object and provides a glitter for the storage of small quantities of substances, including substances biological, consisting of a segment of tube fitted inside one of its ends of a sealing means, characterized in that said sealing means is consisting of a hydrophobic microporous one-piece stopper.
  • microporous plug of the straw according to the present invention consists of a part made of polymeric material and of cylindrical shape and it is composed of a fiber full. Said solid fiber is advantageously produced by an extrusion process continued.
  • the pore diameter of the microporous plug of the straw of the present invention is preferably between about 0.2 and 2 ⁇ m, more preferably about 1 ⁇ m but may have other values between about 0.001 and 10 ⁇ m.
  • the polymer material of the straw cap is chosen from polypropylene, high density polyethylene (PE-HD), polyamides, nitrocellulose, polyesters, phenol-formaldehyde resins (PF resins) and perfluoroalkoxy resins (PFA), etc.
  • the material polymer of the glitter cap is high density polyethylene.
  • the diameter of the plug is obviously adapted to that of the section of the straw tube in which it is used. In general, this diameter will be between 100 ⁇ m and 1 cm. According to the invention, the diameter of the front plug introduction into the glitter is very slightly greater than the inside diameter of the sparkling.
  • the plug of the straw of the present invention is non-absorbent vis-à-vis liquids. It allows only gases, especially air, to pass through intrusion (this pressure obviously depends on the porosity).
  • This pressure obviously depends on the porosity.
  • the man of art will understand that the diameter of the pores of the stopper according to the invention must be adapted in function of said intrusion pressure, preferably around 1 ⁇ m.
  • the other end of the glitter that is to say the one without the cap according to the invention, remains normally open for the introduction of the product to store, which is usually a liquid.
  • the open end is closed, for example by welding, in particular ultrasonic or thermal, or any other suitable technique known to those skilled in the art.
  • the cap of the invention has many advantages: it is non-toxic, sterilizable, it can be frozen or reheated without damage.
  • the stopper of the invention does not absorb the diluent or the sperm.
  • the plug of the invention is also particularly advantageous because it allows only part of the liquid contained in the straw to be withdrawn while keeping the latter for later use. This was not possible with the tripartite plug of the prior art.
  • this non-absorbent plug allows, due to its constitution (material) good adhesion to the parts of the glitter, thus avoiding the well-known backwashing when the cap is used tripartite.
  • Another advantage of the invention is the simplicity of construction, the cap being made up of a single piece instead of three.
  • Another advantage of the invention is that the length of the non-absorbent plug is weaker than that of the tripartite plug. This therefore increases the volume of glitter capacity while remaining within the same standard of dimensions.
  • Another advantage of the invention is that the plug, by its porosity, ensures of course a filtration which makes it possible to work in a more or less sterile mode.
  • Another advantage of the invention is that it is also possible, with the same flake, reabsorb product.
  • the invention is illustrated schematically by the appended figure which is a view in longitudinal section of a straw according to the invention, in which the straw 1 is provided with the hydrophobic microporous one-piece plug 2 according to the invention.
  • the length l of plug 2 is usually between about 2 and 5 mm but not only.
  • the internal diameter d of the straw 1 is very slightly less than the diameter of the cap before introduction into the straw to ensure good sealing between the cap and the internal wall of the straw.
  • the fiber used in the straw cap according to the present invention is a solid fiber obtained in the same way as conventional hollow fibers, by a processes well known to those skilled in the art, described in particular in patents US-A-4,778,601 and US-A-4,828,772, using an extrusion head but without the tube intended to make fiber light.
  • TIPS process phase separation by thermal inversion
  • 10% of high density polyethylene (PE-HD) and a diluent, composed of an appropriate solvent can be a simple solvent or a mixture of solvents, are injected into a extruder heated to high temperature to form a molten liquid, and then forced through an orifice.
  • the molten extrudate then in the form of a cylinder, is cooled by passage through a hot water bath. Lower bath temperature causes the molten material to cool and phase separation between the polymer and thinner.
  • the diluent, remaining in the gel thus obtained in the form of a wire continuous, can be extracted using a suitable solvent.
  • the extruded fiber is then dried by evaporation to obtain the final product.
  • the solid fibers typically obtained using this process have a diameter of approximately 1 to 3 mm with a bubble point of approximately 2.10 4 to 3.10 4 Pa (0.2 to 0.3 bar). Fibers with different characteristics can also be obtained.
  • the fiber full of the invention should preferably have a diameter very slightly greater than that of said flake, the good sealing of the solid fiber being obtained thanks to the slight compression resulting.
  • a straw according to the invention has been produced with a microporous one-piece stopper made of a solid fiber of high polyethylene density having a pore diameter of between about 0.2 and 2 ⁇ m.
  • the diameter of the straw was approximately 1.60 mm and the diameter of the stopper before introduction into the glitter was about 1.65mm.
  • the length of the plug in the glitter was about 4 mm.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Artificial Filaments (AREA)
  • Closures For Containers (AREA)
  • External Artificial Organs (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Manufacture Of Alloys Or Alloy Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Table Equipment (AREA)
  • Nonwoven Fabrics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Claims (13)

  1. Besamungsrohr zur Aufbewahrung kleiner Mengen von Substanzen, insbesondere biologischer Substanzen, bestehend aus einem Abschnitt eines Rohrs, das im Inneren einer seiner beiden Enden mit einem Verschlußmittel ausgestattet ist, dadurch gekennzeichnet, daß das Verschlußmittel aus einem hydrophoben, mikroporösen einteiligen Stopfen besteht.
  2. Besamungsrohr nach Anspruch 1, dadurch gekennzeichnet, daß der mikroporöse Stopfen zu einem Teil aus einem Polymermaterial besteht.
  3. Besamungsrohr nach Anspruch 2, dadurch gekennzeichnet, daß der Stopfen eine zylindrische Form aufweist.
  4. Besamungsrohr nach Anspruch 2, dadurch gekennzeichnet, daß der Stopfen aus einer Vollfaser besteht.
  5. Besamungsrohr nach einem der Ansprüche 1 bis 4, dadurch gekennzeichnet, daß der mikroporöse Stopfen einen Porendurchmesser zwischen etwa 0,001 und 10 µm aufweist.
  6. Besamungsrohr nach Anspruch 5, dadurch gekennzeichnet, daß der mikroporöse Stopfen einen Porendurchmesser zwischen etwa 0,2 und 2 µm aufweist.
  7. Besamungsrohr nach einem der Ansprüche 4 und 5, dadurch gekennzeichnet, daß die Faser, aus welcher der mikroporöse Stopfen besteht, einen Dampfdruck von etwas 2·104 bis 3·104 Pa (0,2 bis 0,3 bar) aufweist.
  8. Besamungsrohr nach einem der Ansprüche 1 bis 7, dadurch gekennzeichnet, daß der Stopfen eine Länge zwischen etwa 2 und 5 mm aufweist.
  9. Besamungsrohr nach 2, dadurch gekennzeichnet, daß das Polymermaterial aus Polyethylen hoher Dichte (HD-PE), Polyamiden, Nitrocellulose, Polyestern, Phenol/Formol-Harzen (PF-Harzen) und Perfluoralkoxyharzen (PFA) ausgewählt ist.
  10. Besamungsrohr nach Anspruch 2, dadurch gekennzeichnet, daß das Polymermaterial Polyethylen hoher Dichte ist.
  11. Besamungsrohr nach Anspruch 2, dadurch gekennzeichnet, daß die Vollfaser durch ein kontinuierliches Extrusionsverfahren herstellbar ist.
  12. Besamungsrohr nach Anspruch 2, dadurch gekennzeichnet, daß die Vollfaser durch ein Phasentrennverfahren mittels thermischer Inversion herstellbar ist.
  13. Besamungsrohr nach einem der Ansprüche 1 bis 12, dadurch gekennzeichnet, daß es entweder durch Herausnehmen des Stopfens oder durch Durchblasen durch den Stopfen entleerbar ist.
EP98400900A 1997-04-21 1998-04-10 Besamungsrohr mit einem aus einer mikroporösen Vollfaser hergestellten Stopfen Expired - Lifetime EP0873726B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9704896 1997-04-21
FR9704896A FR2762210B1 (fr) 1997-04-21 1997-04-21 Paillette avec un bouchon en fibre pleine microporeuse

Publications (2)

Publication Number Publication Date
EP0873726A1 EP0873726A1 (de) 1998-10-28
EP0873726B1 true EP0873726B1 (de) 2002-02-13

Family

ID=9506131

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98400900A Expired - Lifetime EP0873726B1 (de) 1997-04-21 1998-04-10 Besamungsrohr mit einem aus einer mikroporösen Vollfaser hergestellten Stopfen

Country Status (8)

Country Link
EP (1) EP0873726B1 (de)
JP (1) JPH10295359A (de)
AT (1) ATE213138T1 (de)
CA (1) CA2233409C (de)
DE (1) DE69803811T2 (de)
DK (1) DK0873726T3 (de)
ES (1) ES2171001T3 (de)
FR (1) FR2762210B1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2771284B1 (fr) 1997-11-24 2000-08-18 Instr Medecine Veterinaire Paillette avec insert adaptateur
FR2788489B1 (fr) 1999-01-19 2001-03-30 Imv Technologies Procede et systeme pour le conditionnement d'une paillette avec un liquide
FR2804416B1 (fr) 2000-01-31 2002-04-26 Imv Technologies Machine de convoyage et d'amenee en position de tubes, notamment de paillettes
FR2824255B1 (fr) * 2001-05-07 2004-02-06 Imv Technologies Paillette pour la conservation de petites quantites de substances, notamment de liquides biologiques
FR2932064B1 (fr) * 2008-06-06 2010-08-13 Imv Technologies Paillette pour la conservation d'une dose de substance a base liquide, notamment une substance biologique
EP2198804A1 (de) 2008-12-18 2010-06-23 IMV Technologies Stroh zur Konservierung einer vorbestimmten Dosis einer flüssigen Basissubstanz, insbesondere einer biologischen Substanz
FR3004332B1 (fr) 2013-04-11 2018-03-02 Imv Technologies Paillette pour la conservation d'une dose predeterminee de substance a base liquide, notamment de la semence animale pure ou diluee
US20160120172A1 (en) 2013-05-30 2016-05-05 Cryogenetics As Cryopreservation device for biological material
FR3011732B1 (fr) 2013-10-15 2016-09-09 Imv Tech Paillette pour la conservation d'une dose predeterminee de substance a base liquide, notamment de la semence animale pure ou diluee ; et ensemble la comportant
FR3011731B1 (fr) 2013-10-15 2016-10-28 Imv Tech Paillette pour la conservation d'une dose predeterminee de substance a base liquide, notamment de la semence animale pure ou diluee; et ensemble la comportant
FR3017792B1 (fr) * 2014-02-21 2019-08-23 Imv Technologies Paillette pour la conservation d'une dose predeterminee de substance a base liquide, notamment une substance biologique
FR3017793B1 (fr) 2014-02-21 2019-08-23 Imv Technologies Paillette pour la conservation d'une dose predeterminee de substance a base liquide, notamment une substance biologique
FR3021522A1 (fr) 2014-05-28 2015-12-04 Imv Technologies Paillette pour la conservation d'une dose predeterminee de substance a base liquide, notamment de la semence animale diluee ; milieu de dilution pour donner une telle substance ; et systeme les comportant
FR3034980B1 (fr) 2015-04-20 2017-05-12 Imv Tech Paillette pour la conservation d'une dose predeterminee de substance a base liquide
FR3036954B1 (fr) 2015-06-03 2017-07-14 Imv Tech Paillette pour la conservation d'une dose predeterminee de substance a base liquide, ainsi que dispositif d'injection et procede la mettant en oeuvre
FR3074419B1 (fr) 2017-12-05 2019-12-27 Imv Technologies Paillette pour la conservation cryogenique d'une dose de substance a base liquide, ensemble la comportant et procede de vidage de cette paillette

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE498210A (de) 1949-09-20
GB1192946A (en) * 1967-10-12 1970-05-28 Colin Mcewin Duncan Improvements in or relating to Artificial Insemination of Animals
US4778601A (en) 1984-10-09 1988-10-18 Millipore Corporation Microporous membranes of ultrahigh molecular weight polyethylene
US4828772A (en) 1984-10-09 1989-05-09 Millipore Corporation Microporous membranes of ultrahigh molecular weight polyethylene
DE3868782D1 (de) * 1987-07-22 1992-04-09 Robert Cassou Roehrchen zur aufbewahrung von kleinen mengen, insbesondere von biologischen substanzen, und dessen verwendung bei einem befruchtungsverfahren.
FR2651676B1 (fr) * 1989-09-14 1991-11-29 Derien Jean Charles Paille d'aspiration pour prelevement de produits liquides mouillants, procede et moyens de realisation de cette paille.

Also Published As

Publication number Publication date
CA2233409A1 (fr) 1998-10-21
JPH10295359A (ja) 1998-11-10
EP0873726A1 (de) 1998-10-28
ES2171001T3 (es) 2002-08-16
CA2233409C (fr) 2004-12-14
DE69803811D1 (de) 2002-03-21
DE69803811T2 (de) 2002-09-26
ATE213138T1 (de) 2002-02-15
DK0873726T3 (da) 2002-04-29
FR2762210A1 (fr) 1998-10-23
FR2762210B1 (fr) 1999-07-02

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