EP0865434A4 - - Google Patents

Info

Publication number
EP0865434A4
EP0865434A4 EP96903481A EP96903481A EP0865434A4 EP 0865434 A4 EP0865434 A4 EP 0865434A4 EP 96903481 A EP96903481 A EP 96903481A EP 96903481 A EP96903481 A EP 96903481A EP 0865434 A4 EP0865434 A4 EP 0865434A4
Authority
EP
European Patent Office
Prior art keywords
salts
image
present
ch2ch3
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP96903481A
Other languages
English (en)
Other versions
EP0865434B1 (en
EP0865434A1 (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/369,830 external-priority patent/US5574040A/en
Application filed filed Critical
Publication of EP0865434A4 publication Critical patent/EP0865434A4/xx
Publication of EP0865434A1 publication Critical patent/EP0865434A1/en
Application granted granted Critical
Publication of EP0865434B1 publication Critical patent/EP0865434B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/16—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EP96903481A 1995-01-06 1996-01-05 Compounds and their use to treat infectious diseases Expired - Lifetime EP0865434B1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US369830 1995-01-06
US08/369,830 US5574040A (en) 1995-01-06 1995-01-06 Pyrimidine compounds and methods of use to derivatize neighboring lysine residues in proteins under physiologic conditions
US08/463,405 US5733932A (en) 1995-01-06 1995-06-05 Compounds and methods of use to derivatize neighboring lysine residues in proteins under physiological conditions
US463405 1995-06-05
PCT/US1996/000486 WO1996020932A1 (en) 1995-01-06 1996-01-05 Compounds and methods of use to treat infectious diseases

Publications (3)

Publication Number Publication Date
EP0865434A4 true EP0865434A4 (enExample) 1998-09-23
EP0865434A1 EP0865434A1 (en) 1998-09-23
EP0865434B1 EP0865434B1 (en) 2003-12-17

Family

ID=27004718

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96903481A Expired - Lifetime EP0865434B1 (en) 1995-01-06 1996-01-05 Compounds and their use to treat infectious diseases

Country Status (7)

Country Link
US (4) US5733932A (enExample)
EP (1) EP0865434B1 (enExample)
AT (1) ATE256667T1 (enExample)
AU (1) AU715844B2 (enExample)
CA (1) CA2218561C (enExample)
DE (1) DE69631158T2 (enExample)
WO (1) WO1996020932A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9224739D0 (en) * 1992-11-26 1993-01-13 Wellcome Found Medicaments
US6297253B1 (en) * 1996-10-15 2001-10-02 The Picower Institute For Medical Research Compounds and methods of use to treat infectious diseases
WO2000040246A1 (en) * 1999-01-08 2000-07-13 University Of Massachusetts Detection of human immunodeficiency virus
US6734192B1 (en) 1999-08-23 2004-05-11 Mp-1 Inc. Treatment of viral infections
ES2154604B1 (es) * 1999-09-06 2001-11-16 Gonzalez Regueral Valdes Jose Medicacion de uso topico aplicable para el tratamiento de enfermedades producidas por virus, especialmente el herpes simplex de los tipos h sv1 y hsv2
DE60043397D1 (de) * 1999-12-28 2010-01-07 Pharmacopeia Inc Cytokine, insbesondere tnf-alpha, hemmer
US6906067B2 (en) * 1999-12-28 2005-06-14 Bristol-Myers Squibb Company N-heterocyclic inhibitors of TNF-α expression
US20040127502A1 (en) 2001-01-31 2004-07-01 Synaptic Pharmaceutical Corporation Use of GAL3 antagonist for treatment of depression
US7081470B2 (en) * 2001-01-31 2006-07-25 H. Lundbeck A/S Use of GALR3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
US6797464B2 (en) * 2002-07-10 2004-09-28 University Of Massachusetts Detection of drug-resistant human immunodeficiency virus
CN103169708B (zh) 2002-07-29 2018-02-02 里格尔药品股份有限公司 用2,4‑嘧啶二胺化合物治疗或者预防自体免疫性疾病的方法
JP2006528617A (ja) * 2003-07-24 2006-12-21 ファーマジーン ラボラトリーズ リミテッド ５−ｈｔ２ｂ受容体アンタゴニスト
US7122542B2 (en) 2003-07-30 2006-10-17 Rigel Pharmaceuticals, Inc. Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
ATE540035T1 (de) * 2004-11-24 2012-01-15 Rigel Pharmaceuticals Inc Spiro-2,4-pyrimidindiamin-verbindungen und ihre verwendungen
US20060270694A1 (en) * 2005-05-03 2006-11-30 Rigel Pharmaceuticals, Inc. JAK kinase inhibitors and their uses
WO2006130832A2 (en) * 2005-06-02 2006-12-07 The General Hospital Corporation Anti-infective and immunomodulatory compounds

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2113916A1 (enExample) * 1970-11-10 1972-06-30 Armour Pharma
US3908013A (en) * 1970-09-17 1975-09-23 Armour Pharma Pharmaceutical aromatic guanidine compositions and methods of using same
WO1991018887A1 (en) * 1990-06-06 1991-12-12 Smithkline Beecham Intercredit B.V. Diaminopyrimidine compounds
WO1995019767A1 (en) * 1994-01-21 1995-07-27 The Picower Institute For Medical Research Guanylhydrazones for treating inflammatory conditions

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4051256A (en) * 1976-09-19 1977-09-27 Imperial Chemical Industries Limited Guanidine derivatives
DK130584A (da) * 1983-04-08 1984-10-09 Ciba Geigy Ag N-(2-nitrophenyl)-4-amino-pyrimidin-derivater samt deres fremstilling og anvendelse som mikrobicider
GB8510758D0 (en) * 1985-04-27 1985-06-05 Wellcome Found Compounds
JPH0629263B2 (ja) * 1985-10-30 1994-04-20 クミアイ化学工業株式会社 ピリミジン誘導体および農園芸用殺菌剤
US5093525A (en) * 1986-07-10 1992-03-03 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University N,N'-disubstituted guanidines and their use as excitatory amino acid antagonists
US4782062A (en) * 1987-05-11 1988-11-01 Merck & Co., Inc. 9-(2-hydroxymethyl)cycloalkylmethyl) guanines
US4900813A (en) * 1987-07-02 1990-02-13 Ciba-Geigy Corporation Fiber-reactive azo dyes having a 4,6-diaminopyridine coupling component
PH27460A (en) * 1989-12-28 1993-07-09 Kumiai Chemical Industry Co Pyrimidine derivatives and herbicidal composition containing the same
DE4120247A1 (de) * 1991-06-19 1992-12-24 Henkel Kgaa Neue tetraaminopyrimidin-derivate und deren verwendung in oxidationsfaerbemitteln

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3908013A (en) * 1970-09-17 1975-09-23 Armour Pharma Pharmaceutical aromatic guanidine compositions and methods of using same
FR2113916A1 (enExample) * 1970-11-10 1972-06-30 Armour Pharma
WO1991018887A1 (en) * 1990-06-06 1991-12-12 Smithkline Beecham Intercredit B.V. Diaminopyrimidine compounds
WO1995019767A1 (en) * 1994-01-21 1995-07-27 The Picower Institute For Medical Research Guanylhydrazones for treating inflammatory conditions

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 100, no. 10, 1984, Columbus, Ohio, US; abstract no. 68812e, YASUO YUKI: "PREP.,REACTION A.POLYMERIZAT.OF ISOPROPENYL-1,3,5-TRIAZINES" page 4; XP002061167 *
CHEMICAL ABSTRACTS, vol. 114, no. 7, 1991, Columbus, Ohio, US; abstract no. 62037y, K.GHONEIM: "SYNTHESIS OF SOME MANNICH BASES OF 2-AND 4-AMINO-AND 2,4-DIAMINO-6-METHYLPYRIMIDINES" page 684; XP002061165 *
CHEMICAL ABSTRACTS, vol. 124, no. 3, 1996, Columbus, Ohio, US; abstract no. 29691r, M.KANDEEL ET AL.: "SYNTHESIS OF CERTAIN 1,2,3-SELENADIAZOLE" page 970; XP002061164 *
CHEMICAL ABSTRACTS, vol. 53, no. 00, 1959, Columbus, Ohio, US; abstract no. 3479e, C.M.KAGAWA: "DIURETIC EFFECTS OF FORMOGUANAMINE AND OTHER S-TRIAZINES." page 0; column 1; XP002061166 *
EGYPT J. CHEM., vol. 30, no. 6, 1989, CAIRO, pages 295 - 304 *
J.PHARMACOL. EXPTL. THERAP., vol. 124, 1958, USA, pages 318 - 323 *
KOBUNSHI RONBUNSHU, vol. 40, no. 12, 1983, JP, pages 777 - 783 *
ZAGAZIG J. PHARM. SCI., vol. 3, no. 3B, 1994, EGYPT, pages 197 - 205 *

Also Published As

Publication number Publication date
WO1996020932A1 (en) 1996-07-11
DE69631158D1 (de) 2004-01-29
EP0865434B1 (en) 2003-12-17
AU4755996A (en) 1996-07-24
DE69631158T2 (de) 2004-08-26
CA2218561C (en) 2009-09-15
AU715844B2 (en) 2000-02-10
CA2218561A1 (en) 1996-07-11
US5703086A (en) 1997-12-30
US5733932A (en) 1998-03-31
US5620983A (en) 1997-04-15
US5840893A (en) 1998-11-24
EP0865434A1 (en) 1998-09-23
ATE256667T1 (de) 2004-01-15

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