CA2218561C - Compounds and methods of use to treat infectious diseases - Google Patents
Compounds and methods of use to treat infectious diseases Download PDFInfo
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- CA2218561C CA2218561C CA002218561A CA2218561A CA2218561C CA 2218561 C CA2218561 C CA 2218561C CA 002218561 A CA002218561 A CA 002218561A CA 2218561 A CA2218561 A CA 2218561A CA 2218561 C CA2218561 C CA 2218561C
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- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
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- WKSAUQYGYAYLPV-UHFFFAOYSA-N pyrimethamine Chemical compound CCC1=NC(N)=NC(N)=C1C1=CC=C(Cl)C=C1 WKSAUQYGYAYLPV-UHFFFAOYSA-N 0.000 description 1
- 229960000611 pyrimethamine Drugs 0.000 description 1
- ROSKZJGILXBSFM-UHFFFAOYSA-N pyrimidin-2-ylmethanamine Chemical compound NCC1=NC=CC=N1 ROSKZJGILXBSFM-UHFFFAOYSA-N 0.000 description 1
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- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
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- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/16—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
- C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US369,830 | 1995-01-06 | ||
| US08/369,830 US5574040A (en) | 1995-01-06 | 1995-01-06 | Pyrimidine compounds and methods of use to derivatize neighboring lysine residues in proteins under physiologic conditions |
| US463,405 | 1995-06-05 | ||
| US08/463,405 US5733932A (en) | 1995-01-06 | 1995-06-05 | Compounds and methods of use to derivatize neighboring lysine residues in proteins under physiological conditions |
| PCT/US1996/000486 WO1996020932A1 (en) | 1995-01-06 | 1996-01-05 | Compounds and methods of use to treat infectious diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2218561A1 CA2218561A1 (en) | 1996-07-11 |
| CA2218561C true CA2218561C (en) | 2009-09-15 |
Family
ID=27004718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002218561A Expired - Fee Related CA2218561C (en) | 1995-01-06 | 1996-01-05 | Compounds and methods of use to treat infectious diseases |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US5733932A (enExample) |
| EP (1) | EP0865434B1 (enExample) |
| AT (1) | ATE256667T1 (enExample) |
| AU (1) | AU715844B2 (enExample) |
| CA (1) | CA2218561C (enExample) |
| DE (1) | DE69631158T2 (enExample) |
| WO (1) | WO1996020932A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9224739D0 (en) * | 1992-11-26 | 1993-01-13 | Wellcome Found | Medicaments |
| US6297253B1 (en) * | 1996-10-15 | 2001-10-02 | The Picower Institute For Medical Research | Compounds and methods of use to treat infectious diseases |
| WO2000040246A1 (en) * | 1999-01-08 | 2000-07-13 | University Of Massachusetts | Detection of human immunodeficiency virus |
| US6734192B1 (en) | 1999-08-23 | 2004-05-11 | Mp-1 Inc. | Treatment of viral infections |
| ES2154604B1 (es) * | 1999-09-06 | 2001-11-16 | Gonzalez Regueral Valdes Jose | Medicacion de uso topico aplicable para el tratamiento de enfermedades producidas por virus, especialmente el herpes simplex de los tipos h sv1 y hsv2 |
| DE60043397D1 (de) * | 1999-12-28 | 2010-01-07 | Pharmacopeia Inc | Cytokine, insbesondere tnf-alpha, hemmer |
| US6906067B2 (en) * | 1999-12-28 | 2005-06-14 | Bristol-Myers Squibb Company | N-heterocyclic inhibitors of TNF-α expression |
| US20040127502A1 (en) | 2001-01-31 | 2004-07-01 | Synaptic Pharmaceutical Corporation | Use of GAL3 antagonist for treatment of depression |
| US7081470B2 (en) * | 2001-01-31 | 2006-07-25 | H. Lundbeck A/S | Use of GALR3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| US6797464B2 (en) * | 2002-07-10 | 2004-09-28 | University Of Massachusetts | Detection of drug-resistant human immunodeficiency virus |
| CN103169708B (zh) | 2002-07-29 | 2018-02-02 | 里格尔药品股份有限公司 | 用2,4‑嘧啶二胺化合物治疗或者预防自体免疫性疾病的方法 |
| JP2006528617A (ja) * | 2003-07-24 | 2006-12-21 | ファーマジーン ラボラトリーズ リミテッド | ５−ｈｔ２ｂ受容体アンタゴニスト |
| US7122542B2 (en) | 2003-07-30 | 2006-10-17 | Rigel Pharmaceuticals, Inc. | Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds |
| ATE540035T1 (de) * | 2004-11-24 | 2012-01-15 | Rigel Pharmaceuticals Inc | Spiro-2,4-pyrimidindiamin-verbindungen und ihre verwendungen |
| US20060270694A1 (en) * | 2005-05-03 | 2006-11-30 | Rigel Pharmaceuticals, Inc. | JAK kinase inhibitors and their uses |
| WO2006130832A2 (en) * | 2005-06-02 | 2006-12-07 | The General Hospital Corporation | Anti-infective and immunomodulatory compounds |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3908013A (en) * | 1970-09-17 | 1975-09-23 | Armour Pharma | Pharmaceutical aromatic guanidine compositions and methods of using same |
| GB1362389A (en) * | 1970-11-10 | 1974-08-07 | Armour Pharma | Pharmaceutical preparations containing certain guanidine compounds |
| US4051256A (en) * | 1976-09-19 | 1977-09-27 | Imperial Chemical Industries Limited | Guanidine derivatives |
| DK130584A (da) * | 1983-04-08 | 1984-10-09 | Ciba Geigy Ag | N-(2-nitrophenyl)-4-amino-pyrimidin-derivater samt deres fremstilling og anvendelse som mikrobicider |
| GB8510758D0 (en) * | 1985-04-27 | 1985-06-05 | Wellcome Found | Compounds |
| JPH0629263B2 (ja) * | 1985-10-30 | 1994-04-20 | クミアイ化学工業株式会社 | ピリミジン誘導体および農園芸用殺菌剤 |
| US5093525A (en) * | 1986-07-10 | 1992-03-03 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | N,N'-disubstituted guanidines and their use as excitatory amino acid antagonists |
| US4782062A (en) * | 1987-05-11 | 1988-11-01 | Merck & Co., Inc. | 9-(2-hydroxymethyl)cycloalkylmethyl) guanines |
| US4900813A (en) * | 1987-07-02 | 1990-02-13 | Ciba-Geigy Corporation | Fiber-reactive azo dyes having a 4,6-diaminopyridine coupling component |
| PH27460A (en) * | 1989-12-28 | 1993-07-09 | Kumiai Chemical Industry Co | Pyrimidine derivatives and herbicidal composition containing the same |
| GB9012592D0 (en) * | 1990-06-06 | 1990-07-25 | Smithkline Beecham Intercredit | Compounds |
| DE4120247A1 (de) * | 1991-06-19 | 1992-12-24 | Henkel Kgaa | Neue tetraaminopyrimidin-derivate und deren verwendung in oxidationsfaerbemitteln |
| US5599984A (en) * | 1994-01-21 | 1997-02-04 | The Picower Institute For Medical Research | Guanylhydrazones and their use to treat inflammatory conditions |
-
1995
- 1995-06-05 US US08/463,405 patent/US5733932A/en not_active Expired - Lifetime
- 1995-06-06 US US08/470,103 patent/US5620983A/en not_active Expired - Lifetime
- 1995-06-06 US US08/471,797 patent/US5703086A/en not_active Expired - Lifetime
-
1996
- 1996-01-05 AT AT96903481T patent/ATE256667T1/de not_active IP Right Cessation
- 1996-01-05 US US08/584,857 patent/US5840893A/en not_active Expired - Lifetime
- 1996-01-05 CA CA002218561A patent/CA2218561C/en not_active Expired - Fee Related
- 1996-01-05 DE DE69631158T patent/DE69631158T2/de not_active Expired - Fee Related
- 1996-01-05 WO PCT/US1996/000486 patent/WO1996020932A1/en not_active Ceased
- 1996-01-05 AU AU47559/96A patent/AU715844B2/en not_active Ceased
- 1996-01-05 EP EP96903481A patent/EP0865434B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996020932A1 (en) | 1996-07-11 |
| DE69631158D1 (de) | 2004-01-29 |
| EP0865434B1 (en) | 2003-12-17 |
| AU4755996A (en) | 1996-07-24 |
| DE69631158T2 (de) | 2004-08-26 |
| AU715844B2 (en) | 2000-02-10 |
| CA2218561A1 (en) | 1996-07-11 |
| US5703086A (en) | 1997-12-30 |
| EP0865434A4 (enExample) | 1998-09-23 |
| US5733932A (en) | 1998-03-31 |
| US5620983A (en) | 1997-04-15 |
| US5840893A (en) | 1998-11-24 |
| EP0865434A1 (en) | 1998-09-23 |
| ATE256667T1 (de) | 2004-01-15 |
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